sem history of diabetes
TRANSCRIPT
![Page 1: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/1.jpg)
HISTORY OF DIABETES
Presented By
Kamakshi Bisoyi
1st MBBS, Batch of 2012
![Page 2: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/2.jpg)
DIABETES
• One of the first diseases described with an EGYPTIAN MANUSCRIPT from1500BC. mentioning “too great emptying of the urine”
![Page 3: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/3.jpg)
• Earliest description of diabetes was also documented - writings of Hindu scholars - in 1500 BC.
•They had already described “a mysterious disease causing thirst, enormous urine output, and wasting away of the body with flies and ants attracted to the urine of people.”
•They Identified the Disease and classified it as MADHUMEHA or HONEY URINE
![Page 4: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/4.jpg)
•The term DIABETES was coined by THE GREEK APPOLLONIUS OF MEMPHIS IN 230 BC
•Which literally meant “to go through” or siphon as the disease drained more fluid than a person could consume.
![Page 5: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/5.jpg)
.
MAIN TYPES OF DIABETESType 1 and type 2 diabetes were identified as
separate conditions for the first time by the Indian physicians Sushruta and Charaka in
400-500 AD with type 1 associated with youth and type 2 with being overweight.
![Page 6: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/6.jpg)
• The term "mellitus" or "from honey" was added by the Britain John Rolle in the late 1700s to separate the condition from diabetes insipidus which is also associated with frequent urination.
![Page 7: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/7.jpg)
.
BANTING AND BEST First Used Insulin In 1921& 1922 BANTING & McLOEDRecieved NOBEL PRIZE in PHYSIOLOGY or MEDICINE In 1923.BANTING Is honoured by WORLD DIABETES DAY which is held on his birthday, November 14.
![Page 8: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/8.jpg)
•First complete description by Ancient Greek
physician
ARETAES OF CAPPADOCIA•He noted the excessive amount of urine which passed through the kidneys •Gave the disease the name DIABETES.
![Page 9: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/9.jpg)
• Pathogenesis of diabetes has only been understood experimentally since about 1900.
![Page 10: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/10.jpg)
J.V Mering
Oskar
ROLE of PANCREAS
in DIABETES discovered By
JOSEPH VON MERING and
OSKAR in 1889.
![Page 11: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/11.jpg)
In 1910,SIR EDWARD ALBERT SHARPEY suggested diabetic patients were deficient of single chemical - that was normally produced by the pancreas.
Proposed the name INSULIN (Latin Insula) – meaning Island – Islet of Langerhans in Pancreas which produce Insulin
![Page 12: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/12.jpg)
The islets of Langerhans was discovered in 1869 by an anatomist named Paul Langerhans.
![Page 13: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/13.jpg)
Distinction Between TYPE 1 & TYPE 2 DIABETES
by SIR HAROLD PERCIBAL,HARRY HIMSWORTH - published in Jan 1936
![Page 14: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/14.jpg)
Determination Of Amino AcidSequence Of Insulin By Sir FREDERICK SANGER for which he received a Nobel Prize.
![Page 15: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/15.jpg)
Other landmark discoveries • Identification of the first of the sulfonylureas in
1942
• Reintroduction of the use of biguanides for Type 2 diabetes in the late 1950s.
• Identification of the first thiazolidinedione an effective insulin sensitizer during the 1990s
![Page 16: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/16.jpg)
Insulin Changes at a Glance -Decade Development in insulin therapy
• 1920s Regular insulin
• 1930s Long-acting (PZI)
• 1940s Intermediate-acting (NPH)
• 1950s Lente insulins
• 1960s Purified insulins
• 1970s Recombinant human insulins
• 1980s Insulin analogs
• 1990s… Nasal, oral insulins, and newer delivery devices; the search continues
![Page 17: Sem history of diabetes](https://reader035.vdocuments.mx/reader035/viewer/2022062513/5565d6fed8b42ae8258b4ba8/html5/thumbnails/17.jpg)
THANK YOU