SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Regression Program Version 47 February 2019 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2007-16 2012-16

SEER 9 Delay-Adjusted Incidencea 1975-2016

All Races 1975-81 59 1981-05 29 2005-16 16 16 16

White 1975-81 62 1981-05 32 2005-16 19 19 19

Black 1975-16 -03 -03 -03

SEER 21 Delay-Adjusted Incidenceb 2000-2016

All Races 2000-05 35 2005-16 13 13 13

White 2000-05 38 2005-16 16 16 16

White NHef 2000-05 43 2005-16 19 19 19

Black 2000-16 00 00 00

Black NHef 2000-16 01 01 01

APIe 2000-16 -04 -04 -04

AIANeg 2000-16 27 27 27

Hispanicf 2000-16 07 07 07

US Cancer Mortalityc 1975-2016

Note- Alternate mortality trends adjusted for ICD-9ICD-10 coding change available at httpssurveillancecancergovjoinpointtable1html

All Races 1975-77 47 1977-90 14 1990-02 -03 2002-09 06 2009-14 -12 2014-16 -84 -25 -49

White 1975-77 50 1977-90 15 1990-02 -01 2002-09 08 2009-14 -10 2014-16 -81 -22 -46

Black 1975-14 -08 2014-16 -179 -49 -98

US Cancer Mortalityc 2000-2016

All Races 2000-09 05 2009-14 -12 2014-16 -85 -25 -49

White 2000-13 04 2013-16 -65 -20 -48

White NHef 2000-13 06 2013-16 -63 -18 -46

Black 2000-14 -12 2014-16 -161 -47 -90

Black NHef 2000-14 -12 2014-16 -161 -48 -90

APIe 2000-16 -09 -09 -09

AIANeg 2000-16 -29 -29 -29

Hispanicf 2000-16 -08 -08 -08

Table 161

Melanoma of the Skin (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2016 With up to Five Joinpoints 2000-2016 With up to Three Joinpoints

Both Sexes by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Regression Program Version 47 February 2019 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2007-16 2012-16

SEER 9 Delay-Adjusted Incidencea 1975-2016

All Races 1975-85 56 1985-05 32 2005-16 17 17 17

White 1975-85 59 1985-05 34 2005-16 19 19 19

Black 1975-16 -06 -06 -06

SEER 21 Delay-Adjusted Incidenceb 2000-2016

All Races 2000-05 38 2005-16 14 14 14

White 2000-05 41 2005-16 16 16 16

White NHef 2000-05 43 2005-16 20 20 20

Black 2000-16 -04 -04 -04

Black NHef 2000-16 -05 -05 -05

APIe 2000-16 -04 -04 -04

AIANeg 2000-16 04 04 04

Hispanicf 2000-16 05 05 05

US Cancer Mortalityc 1975-2016

Note- Alternate mortality trends adjusted for ICD-9ICD-10 coding change available at httpssurveillancecancergovjoinpointtable1html

All Races 1975-87 24 1987-97 09 1997-00 -17 2000-09 10 2009-14 -13 2014-16 -85 -25 -50

White 1975-87 25 1987-97 10 1997-00 -16 2000-09 11 2009-14 -10 2014-16 -83 -22 -47

Black 1975-16 -09 -09 -09

US Cancer Mortalityc 2000-2016

All Races 2000-09 10 2009-14 -13 2014-16 -85 -25 -50

White 2000-09 11 2009-14 -10 2014-16 -83 -22 -47

White NHef 2000-09 13 2009-14 -09 2014-16 -81 -20 -46

Black 2000-16 -12 -12 -12

Black NHef 2000-16 -11 -11 -11

APIe 2000-16 -21 -21 -21

AIANeg 2000-16 -22 -22 -22

Hispanicf 2000-16 -05 -05 -05

Table 162

Melanoma of the Skin (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2016 With up to Five Joinpoints 2000-2016 With up to Three Joinpoints

Males by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Regression Program Version 47 February 2019 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2007-16 2012-16

SEER 9 Delay-Adjusted Incidencea 1975-2016

All Races 1975-80 55 1980-05 25 2005-16 16 16 16

White 1975-81 62 1981-93 21 1993-05 35 2005-12 09 2012-16 36 21 36

Black 1975-16 -02 -02 -02

SEER 21 Delay-Adjusted Incidenceb 2000-2016

All Races 2000-16 16 16 16

White 2000-16 19 19 19

White NHef 2000-16 23 23 23

Black 2000-16 02 02 02

Black NHef 2000-16 04 04 04

APIe 2000-16 -05 -05 -05

AIANeg 2000-16 55 55 55

Hispanicf 2000-16 06 06 06

US Cancer Mortalityc 1975-2016

Note- Alternate mortality trends adjusted for ICD-9ICD-10 coding change available at httpssurveillancecancergovjoinpointtable1html

All Races 1975-88 08 1988-14 -06 2014-16 -93 -26 -51

White 1975-86 11 1986-13 -03 2013-16 -57 -21 -44

Black 1975-97 03 1997-16 -26 -26 -26

US Cancer Mortalityc 2000-2016

All Races 2000-14 -06 2014-16 -93 -26 -50

White 2000-13 -02 2013-16 -59 -22 -45

White NHef 2000-13 00 2013-16 -56 -19 -42

Black 2000-16 -27 -27 -27

Black NHef 2000-16 -28 -28 -28

APIe 2000-16 -01 -01 -01

AIANeg - - - -

Hispanicf 2000-16 -11 -11 -11

Table 163

Melanoma of the Skin (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2016 With up to Five Joinpoints 2000-2016 With up to Three Joinpoints

Females by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Note Delay-adjusted melanoma of the skin rates cannot be calculated for the SEER 9 Black population due to low case countsReference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review

a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval

All Races Whites Total Males Females Total Males Females

Year of Diagnosis1975-1979 870 944 819 975 1056 9221980 1051 1180 963 1203 1341 11111981 1108 1207 1045 1259 1357 12031982 1119 1250 1029 1284 1422 11911983 1108 1267 1001 1264 1440 11491984 1141 1291 1044 1311 1482 12041985 1278 1516 1116 1458 1731 12771986 1332 1567 1163 1527 1792 13411987 1367 1594 1215 1567 1819 14021988 1289 1497 1148 1499 1740 13411989 1375 1639 1193 1597 1899 13921990 1387 1668 1187 1620 1935 13991991 1463 1760 1255 1715 2051 14811992 1477 1831 1221 1731 2138 14401993 1464 1822 1206 1713 2119 14221994 1567 1985 1262 1847 2333 14941995 1651 2034 1384 1946 2365 16601996 1739 2175 1424 2063 2552 17121997 1777 2175 1489 2108 2540 18021998 1795 2216 1502 2153 2631 18261999 1836 2296 1515 2205 2715 18502000 1901 2400 1552 2297 2854 19132001 1974 2462 1633 2402 2947 20242002 1937 2405 1615 2349 2867 20002003 1959 2428 1627 2395 2911 20362004 2071 2557 1736 2540 3094 21602005 2250 2822 1847 2785 3429 23322006 2216 2777 1817 2734 3355 22922007 2187 2768 1784 2701 3349 22562008 2328 2942 1895 2888 3581 24012009 2323 2956 1872 2873 3594 23552010 2402 3019 1965 2975 3657 24952011 2308 2932 1865 2872 3574 23712012 2318 2985 1835 2890 3643 23422013 2438 3114 1942 3036 3786 24872014 2563 3245 2063 3228 3987 26732015 2616 3248 2157 3317 4026 27972016 2583 3252 2089 3252 4002 2697

Table 164Melanoma of the Skin (Invasive)

Delay-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2016 1801 2251 1494 2143 2651 1803 100 115 0911975-1979 870 944 819 975 1056 922 112 116 1111980 1051 1180 963 1203 1341 1111 - - -1981 1108 1207 1045 1259 1357 1203 135 - -1982 1119 1250 1029 1284 1422 1191 - - -1983 1108 1267 1001 1264 1440 1149 - - -1984 1141 1291 1044 1311 1482 1204 - - -1985 1278 1516 1116 1458 1731 1277 - - -1986 1332 1567 1163 1527 1792 1341 - - -1987 1367 1594 1215 1567 1819 1402 130 - -1988 1289 1497 1148 1499 1740 1341 112 - -1989 1375 1639 1193 1597 1899 1392 113 - -1990 1387 1668 1187 1620 1935 1399 122 - -1991 1463 1760 1255 1715 2051 1481 110 - -1992 1477 1831 1221 1731 2138 1440 - - -1993 1464 1822 1206 1713 2119 1422 - - -1994 1567 1985 1262 1847 2333 1494 103 - -1995 1651 2034 1384 1946 2365 1660 168 319 -1996 1739 2175 1424 2063 2552 1712 111 - -1997 1777 2175 1489 2108 2540 1802 110 - -1998 1795 2216 1502 2153 2631 1826 119 - -1999 1836 2296 1515 2205 2715 1850 114 - -2000 1901 2400 1552 2297 2854 1913 092 - -2001 1974 2462 1633 2402 2947 2024 076 - -2002 1937 2405 1615 2349 2867 2000 111 - -2003 1959 2428 1627 2395 2911 2036 084 - -2004 2071 2557 1736 2540 3094 2160 085 - -2005 2250 2822 1847 2785 3429 2332 107 - 1032006 2216 2777 1817 2734 3355 2292 098 - -2007 2187 2768 1784 2701 3349 2256 122 - 1202008 2325 2939 1893 2882 3574 2396 122 133 -2009 2317 2949 1867 2862 3580 2346 115 111 1112010 2394 3009 1958 2957 3635 2480 107 - 0972011 2298 2918 1856 2850 3547 2353 107 - 1132012 2306 2969 1824 2863 3609 2320 082 - -2013 2421 3094 1929 3002 3744 2459 087 - -2014 2540 3216 2045 3181 3928 2634 100 116 0912015 2586 3210 2131 3253 3948 2744 094 - 0912016 2538 3196 2052 3159 3887 2620 080 - -

Table 165Melanoma of the Skin (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2016 261 377 175 295 424 198 046 052 0421975-1979 226 292 174 248 319 191 052 065 0431980 234 310 174 257 341 190 054 055 0561981 243 313 188 268 345 207 058 056 0571982 246 331 181 271 364 199 052 056 0491983 248 329 185 274 363 204 050 063 0401984 253 342 185 280 379 203 051 045 0541985 256 346 186 283 382 206 053 058 0491986 259 355 188 288 392 209 047 070 0311987 265 373 183 293 413 202 055 057 0541988 265 367 190 295 407 213 045 053 0401989 269 374 189 299 415 210 055 057 0531990 275 380 197 306 421 220 052 065 0451991 271 389 182 301 431 202 059 065 0541992 271 385 185 301 427 206 051 057 0441993 271 386 186 303 431 206 053 042 0591994 266 382 181 298 426 203 045 044 0431995 270 389 181 303 435 202 046 051 0421996 280 404 190 314 450 214 044 051 0381997 273 394 184 306 441 205 056 049 0581998 275 409 177 310 459 198 051 045 0541999 263 381 174 297 427 198 040 052 0332000 266 382 181 300 428 204 054 059 0502001 266 389 175 302 438 199 042 035 0452002 261 379 173 296 425 197 039 050 0322003 267 390 175 303 440 198 045 043 0452004 267 397 171 305 448 195 045 056 0392005 276 403 181 313 454 207 045 049 0412006 274 410 173 312 463 198 045 062 0362007 268 401 169 306 454 193 047 053 0452008 269 405 165 308 461 190 039 044 0352009 281 420 178 324 477 206 043 054 0352010 274 410 171 315 467 196 042 049 0382011 269 404 167 311 461 193 041 042 0412012 266 395 168 307 452 195 039 044 0342013 266 401 163 309 460 191 040 051 0312014 257 385 158 299 443 184 039 043 0372015 241 356 152 281 410 178 035 051 0242016 217 325 134 254 376 158 027 031 024

Table 166Melanoma of the Skin (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2012-2016All ages 222 288 175 266 339 213 10 11 09Under 65 124 127 123 152 153 153 05 05 0565 and over 902 1404 534 1055 1630 625 47 55 41

All ages (WHO world std)c 171 210 142 206 248 174 07 08 07

Age-Specific Rates 2012-2016lt1 - - - - - - - - -1-4 01 - 02 01 - 02 - - -5-9 02 01 02 02 01 03 - - -10-14 03 03 03 04 03 04 - - -15-19 09 07 11 12 10 14 - - -20-24 30 18 43 38 22 56 - - -25-29 60 37 84 76 47 107 - - -30-34 95 68 123 121 86 157 03 - -35-39 117 95 140 147 118 178 05 - 0640-44 156 136 176 195 166 224 04 - -45-49 214 202 225 265 247 282 07 07 0750-54 294 312 278 358 374 342 12 11 1355-59 388 465 315 465 552 381 15 16 1460-64 513 663 375 611 783 450 21 27 1665-69 689 958 452 812 1116 536 30 36 2670-74 837 1244 497 984 1448 587 42 47 3975-79 991 1536 568 1173 1804 672 48 57 4380-84 1112 1833 613 1288 2107 709 64 95 4785+ 1104 1997 643 1259 2286 724 70 64 72

US MortalityAge at DeathAge-Adjusted Rates 2012-2016All ages 25 37 15 29 43 18 04 04 03Under 65 10 13 07 12 16 09 01 02 0165 and over 128 205 73 145 231 83 19 23 16

All ages (WHO world std)c 15 22 10 18 25 11 02 03 02

Age-Specific Rates 2012-2016lt1 - - - - - - - - -1-4 - - - - - - - - -5-9 - - - - - - - - -10-14 - - - - - - - - -15-19 00 - - 00 - - - - -20-24 01 01 01 01 01 01 - - -25-29 02 03 02 03 04 03 - - -30-34 05 05 04 06 07 05 - - -35-39 07 09 06 09 11 08 - - -40-44 12 14 09 15 18 12 02 - -45-49 17 20 13 21 25 17 02 03 -50-54 25 32 18 31 39 22 03 04 0355-59 36 50 24 44 60 28 05 06 0460-64 52 74 32 61 87 37 08 09 0765-69 70 103 40 81 118 46 10 16 0670-74 96 146 53 110 166 60 14 18 1175-79 135 208 77 155 237 88 18 19 1880-84 187 312 100 211 349 112 28 38 2185+ 243 420 151 270 465 167 38 41 37

Table 167Melanoma of the Skin (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2016 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2016

d Period survival provides a 2015 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2009-2015 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 60 51 68 - - -1970-1973a - - - 68 62 75 - - -1975-1977b 819 775 863 821 778 863 567g - -1978-1980b 828 777 877 829 779 879 598h - -1981-1983b 828 784 873 828 784 872 619g - -1984-1986b 866 826 910 864 823 910 723h - -1987-1989b 881 849 915 880 849 913 786g - 895g

1990-1992b 893 870 918 893 871 918 596g - -1993-1995b 897 873 926 896 871 926 695g 666g -1996-1998b 910 895 927 909 894 927 739g 680h 786g

1999-2001b 922 902 946 922 902 946 739g 709g 761g

2002-2004b 932 911 954 932 911 956 720g - 704g

2005-2008b 933 917 952 934 918 953 726g 627g 787g

2009-2015b 942f 925f 964f 941f 923f 963f 698g 630g 748g

5-Year Period Survival (Percent)cd

2015 925 907 948 918 898 944 667 571 742

Stage Distribution () 2009-2015ce

All StagesNumber of cases 104803 59231 45572 97299 55300 41999 499 223 276Percent 100 100 100 100 100 100 100 100 100Localized 84 82 86 83 81 86 55 50 59Regional 9 10 7 9 10 8 23 26 21Distant 4 5 3 4 5 3 16 17 16UnstagedUnknown 4 4 4 3 3 4 5 7 4

5-Year Relative Survival (Percent) 2009-2015c

Age at DiagnosisAges lt45 947 915 969 945 911 968 825g 688h 892g

Ages 45-54 933 907 960 929 901 959 663g 605g 722g

Ages 55-64 924 906 952 919 901 948 657g 529g 789g

Ages 65-74 930 918 950 924 912 947 703g 623h 733g

Ages 75+ 870 866 876 856 850 866 418g 349h 433h

Ages lt65 933 908 961 930 904 959 717 599g 814Ages 65+ 904 897 915 894 886 908 575g 524h 593g

StageeAll Stages 922 904 946 916 896 942 668 585 730Localized 987 982 994 983 976 991 878 873g 875Regional 647 621 693 650 624 696 492g 415g 567g

Distant 248 234 277 247 237 269 275g - 401g

UnstagedUnknown 854 830 884 838 811 870 414h - -

Table 168Melanoma of the Skin (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2016 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2016

d Period survival provides a 2015 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2009-2015 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 60 51 68 - - -1970-1973a - - - 68 62 75 - - -1975-1977b 819 775 863 821 778 863 567g - -1978-1980b 828 777 877 829 779 879 598h - -1981-1983b 828 784 873 828 784 872 619g - -1984-1986b 866 826 910 864 823 910 723h - -1987-1989b 881 849 915 880 849 913 786g - 895g

1990-1992b 893 870 918 893 871 918 596g - -1993-1995b 897 873 926 896 871 926 695g 666g -1996-1998b 910 895 927 909 894 927 739g 680h 786g

1999-2001b 922 902 946 922 902 946 739g 709g 761g

2002-2004b 932 911 954 932 911 956 720g - 704g

2005-2008b 933 917 952 934 918 953 726g 627g 787g

2009-2015b 942f 925f 964f 941f 923f 963f 698g 630g 748g

5-Year Period Survival (Percent)cd

2015 925 907 948 918 898 944 667 571 742

Stage Distribution () 2009-2015ce

All StagesNumber of cases 104803 59231 45572 97299 55300 41999 499 223 276Percent 100 100 100 100 100 100 100 100 100Localized 84 82 86 83 81 86 55 50 59Regional 9 10 7 9 10 8 23 26 21Distant 4 5 3 4 5 3 16 17 16UnstagedUnknown 4 4 4 3 3 4 5 7 4

5-Year Relative Survival (Percent) 2009-2015c

Age at DiagnosisAges lt45 947 915 969 945 911 968 825g 688h 892g

Ages 45-54 933 907 960 929 901 959 663g 605g 722g

Ages 55-64 924 906 952 919 901 948 657g 529g 789g

Ages 65-74 930 918 950 924 912 947 703g 623h 733g

Ages 75+ 870 866 876 856 850 866 418g 349h 433h

Ages lt65 933 908 961 930 904 959 717 599g 814Ages 65+ 904 897 915 894 886 908 575g 524h 593g

StageeAll Stages 922 904 946 916 896 942 668 585 730Localized 987 982 994 983 976 991 878 873g 875Regional 647 621 693 650 624 696 492g 415g 567g

Distant 248 234 277 247 237 269 275g - 401g

UnstagedUnknown 854 830 884 838 811 870 414h - -

Table 168Melanoma of the Skin (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Survival Time

1-year 942 956 963 967 973 976 966 967 976 979 974 979 977 977 979 976 978 979 981 978 977 980 986 978 9812-year 898 917 933 939 942 957 943 945 955 962 955 955 961 962 963 961 962 959 961 967 963 965 978 9653-year 861 880 907 919 926 938 923 927 940 945 940 943 949 946 950 947 947 947 948 952 949 959 9644-year 834 855 891 903 912 932 913 915 932 932 927 932 937 936 943 937 941 941 938 945 941 9535-year 820 835 877 893 902 923 898 909 924 921 921 929 933 931 933 930 934 935 933 938 9376-year 803 823 866 885 900 915 893 904 917 917 913 926 924 931 930 923 928 927 929 9367-year 789 817 859 878 900 912 886 903 916 915 911 920 919 925 929 920 927 922 9268-year 779 809 853 872 898 909 878 898 912 914 909 912 918 923 928 920 923 9219-year 771 803 850 870 894 904 876 896 909 914 908 907 918 922 927 920 92210-year 766 797 849 869 894 899 876 892 909 912 902 906 914 922 927 92011-year 760 794 844 866 891 897 876 892 909 909 900 905 914 922 92712-year 756 792 842 865 891 896 871 887 909 908 900 905 914 92213-year 753 788 841 865 886 896 869 886 909 908 899 905 91414-year 751 786 839 863 886 894 867 885 909 908 899 90515-year 747 784 839 863 886 894 865 884 909 908 89916-year 745 784 838 863 886 894 865 878 909 90817-year 745 781 838 863 886 892 865 878 90918-year 745 781 838 863 886 892 865 87819-year 745 781 838 863 886 892 86520-year 745 781 838 863 886 892

Table 169Melanoma of the Skin (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Survival Time

1-year 923 940 952 961 963 966 963 963 971 975 965 968 970 975 976 971 975 971 974 973 971 973 983 972 9752-year 866 887 914 926 921 944 933 938 943 955 938 940 948 956 959 954 954 947 946 960 952 954 969 9543-year 822 843 882 903 900 921 907 919 925 935 915 924 934 928 941 936 933 931 932 941 932 947 9544-year 789 812 862 884 880 912 898 904 914 921 898 908 918 918 929 927 927 923 920 935 922 9365-year 775 786 844 873 868 904 880 901 904 909 892 903 917 911 915 918 918 919 913 925 9166-year 755 772 832 862 864 896 872 895 891 903 882 900 907 911 910 910 910 906 909 9217-year 738 768 822 854 864 894 870 895 890 903 881 896 897 902 906 907 907 900 9098-year 726 760 816 847 862 890 861 892 887 901 880 885 894 898 901 907 904 8959-year 717 752 812 844 858 884 860 887 885 901 880 878 894 895 901 904 90110-year 712 747 812 842 856 879 856 883 885 900 874 878 893 895 897 90411-year 704 744 811 838 856 877 856 881 885 894 871 878 893 895 89712-year 699 743 809 838 856 877 847 875 885 893 871 878 893 89513-year 695 740 808 838 856 877 847 874 885 893 871 878 89314-year 695 736 803 836 856 877 842 872 885 893 871 87815-year 693 736 802 836 856 877 842 872 885 893 87116-year 691 736 799 836 855 877 842 870 885 89317-year 691 736 799 836 855 877 842 870 88518-year 691 736 799 836 855 877 842 87019-year 691 736 799 836 855 877 84220-year 691 736 799 836 855 877

Table 1610Melanoma of the Skin (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Survival Time

1-year 961 973 976 974 985 988 971 971 982 984 985 990 986 980 983 981 981 989 991 983 985 990 990 986 9882-year 929 947 953 954 967 973 954 953 970 970 976 972 975 969 968 970 973 974 978 973 976 979 989 9793-year 899 919 935 939 957 959 941 936 957 957 971 964 966 965 962 959 964 967 967 964 968 974 9784-year 878 899 924 925 949 953 928 926 953 946 961 960 957 956 960 950 957 962 960 956 965 9725-year 864 886 914 918 941 946 918 917 946 934 956 957 951 954 954 944 954 956 958 952 9626-year 850 874 903 912 941 939 916 912 945 933 950 953 945 953 951 938 950 953 952 9527-year 840 866 898 906 940 933 904 910 944 929 947 948 943 950 951 937 950 949 9468-year 831 860 893 902 940 933 897 905 938 928 943 943 941 950 951 937 946 9499-year 824 855 891 901 936 929 895 905 937 928 937 939 940 949 951 937 94510-year 818 847 888 900 936 924 895 902 936 926 934 935 938 949 951 93711-year 815 845 880 898 928 920 895 901 936 925 934 933 938 949 95112-year 810 842 878 896 928 915 895 901 936 925 933 933 934 94913-year 808 837 875 896 919 915 891 899 936 925 933 933 93414-year 803 836 875 895 918 914 891 899 936 925 933 93215-year 799 831 875 895 918 907 889 896 936 925 93316-year 798 828 875 895 918 902 889 887 936 92517-year 798 826 875 895 918 899 889 887 93618-year 797 824 875 895 918 898 889 88719-year 796 824 875 895 918 897 88920-year 796 824 875 895 918 896

Table 1611Melanoma of the Skin (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Devcan 677 April 2019 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 000 001 005 225 029 Asian 0 000 000 000 018 006

10 001 005 015 227 029 Pacific 10 000 000 001 018 006

20 004 015 032 227 029 Islander 20 000 001 002 018 006

30 010 028 059 225 029 30 001 002 004 017 006

40 018 049 098 218 029 40 001 003 006 017 006

50 032 083 144 205 028 50 002 005 010 016 006

60 054 118 168 183 027 60 003 008 011 014 006

70 073 130 - 146 025 70 005 009 - 012 005

80 075 - - 097 020 80 004 - - 008 005

White 0 000 001 006 264 033 American 0 000 000 002 057 007

10 001 006 019 267 033 Indian 10 000 002 004 057 007

20 005 018 040 267 033 Alaska 20 002 004 007 057 007

30 013 035 072 263 034 Nativea 30 003 006 013 057 008

40 022 060 118 254 033 40 003 011 025 056 008

50 039 098 170 238 032 50 008 022 036 054 008

60 063 139 196 211 031 60 016 031 046 050 008

70 086 150 - 167 028 70 017 034 - 039 008

80 086 - - 109 022 80 023 - - 029 006

Black 0 000 000 000 010 004 Hispanicb 0 000 000 001 057 011

10 000 000 001 010 004 10 000 001 003 057 011

20 000 001 001 010 004 20 001 003 007 057 011

30 000 001 002 010 004 30 002 006 013 057 011

40 001 002 004 010 004 40 004 011 022 055 011

50 001 003 006 009 004 50 007 019 032 052 010

60 002 005 008 009 004 60 012 026 040 047 010

70 004 006 - 008 004 70 016 031 - 039 009

80 004 - - 006 003 80 019 - - 028 008

Table 1612

Melanoma of the Skin (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2014-2016 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Devcan 677 April 2019 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 000 001 003 277 039 Asian 0 000 000 000 019 006

10 001 003 011 280 039 Pacific 10 000 000 001 019 006

20 003 011 026 281 040 Islander 20 000 001 002 019 006

30 008 024 058 282 040 30 001 002 003 019 006

40 016 051 114 278 040 40 001 003 006 019 006

50 036 101 186 271 040 50 002 006 011 018 006

60 070 162 233 252 039 60 004 010 014 017 005

70 107 189 - 212 036 70 007 012 - 014 005

80 116 - - 149 031 80 006 - - 009 004

White 0 000 001 004 322 045 American 0 000 000 001 062 010

10 001 004 014 325 045 Indian 10 000 001 003 063 010

20 004 013 032 325 045 Alaska 20 001 003 004 063 010

30 010 029 070 326 046 Nativea 30 002 004 012 064 010

40 020 061 134 321 046 40 002 010 025 064 010

50 043 118 218 311 045 50 009 025 038 066 010

60 081 188 268 289 044 60 017 032 052 062 011

70 124 217 - 241 040 70 017 041 - 052 012

80 132 - - 167 034 80 033 - - 049 011

Black 0 000 000 000 010 004 Hispanicb 0 000 000 001 059 013

10 000 000 000 010 004 10 000 001 002 059 013

20 000 000 001 010 004 20 001 002 005 059 013

30 000 001 002 010 004 30 001 004 010 059 013

40 001 002 004 010 004 40 003 009 021 059 013

50 001 004 007 010 004 50 006 018 033 057 013

60 003 006 008 009 004 60 013 029 046 054 013

70 004 007 - 008 004 70 018 037 - 047 012

80 004 - - 006 004 80 025 - - 038 011

Table 1613

Melanoma of the Skin (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2014-2016 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Devcan 677 April 2019 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 000 001 007 179 019 Asian 0 000 000 000 016 007

10 001 007 019 181 019 Pacific 10 000 000 001 016 007

20 006 019 038 180 019 Islander 20 000 001 002 016 007

30 013 032 060 175 019 30 001 002 004 016 007

40 019 047 084 164 019 40 001 004 007 015 007

50 029 066 105 147 019 50 002 005 009 014 007

60 039 080 113 124 017 60 003 007 009 012 006

70 045 082 - 094 016 70 004 006 - 009 006

80 046 - - 062 013 80 003 - - 007 005

White 0 000 001 009 213 022 American 0 000 001 003 053 005

10 001 008 025 215 022 Indian 10 001 003 006 054 005

20 007 024 048 214 022 Alaska 20 003 006 010 053 005

30 016 041 074 208 022 Nativea 30 003 008 014 051 005

40 025 059 102 193 022 40 005 011 024 049 005

50 035 079 125 172 021 50 006 020 034 045 005

60 046 094 132 144 020 60 014 030 041 041 005

70 053 094 - 107 017 70 017 029 - 030 005

80 052 - - 069 014 80 016 - - 016 003

Black 0 000 000 000 010 004 Hispanicb 0 000 000 002 057 008

10 000 000 001 010 004 10 000 001 004 057 009

20 000 001 001 010 004 20 001 004 009 057 009

30 000 001 002 010 004 30 003 007 015 056 009

40 001 002 003 009 004 40 005 013 023 053 008

50 001 003 006 009 004 50 008 019 032 049 008

60 002 005 007 008 004 60 011 025 037 042 008

70 003 006 - 007 004 70 014 027 - 033 007

80 004 - - 005 003 80 015 - - 023 006

Table 1614

Melanoma of the Skin (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2014-2016 By RaceEthnicity

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 47 February 2019 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2007-2016 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2016

d The 2007-2016 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2016

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2007-2016 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2016 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2012-2016 Trend 2007-2016c Trend 2007-2016d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 222 288 175 11 12 09 15 15 15

White 266 339 213 12 12 10 17 16 17White Hispanice 49 52 49 04 02 04 - - -White Non-Hispanice 312 391 254 15 15 14 - - -

Black 10 11 09 -03 -07 00 -03 -06 -02

AsianPacific Islander 14 16 12 -07 -07 -08 - - -

Amer IndAlaska Natf 55 58 53 15 -07 43 - - -

Hispanice 47 50 47 05 03 04 - - -

US Mortalityg Rate 2012-2016 Trend 2007-2016h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 25 37 15 -25 -25 -26

White 29 43 18 -20 -22 -22White Hispanice 08 10 06 -07 -04 -10White Non-Hispanice 32 47 20 -18 -20 -19

Black 04 04 03 -47 -12 -27

AsianPacific Islander 03 04 03 -09 -21 -01

Amer IndAlaska NatTotal US 05 07 04 -34 -28 -41PRCDA Counties 07 10 05 -29 -22 -Non-PRCDA Counties 03 - - -19 - -

Hispanice 07 09 05 -08 -05 -11

Table 1615Melanoma of the Skin (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2012-2016

California 2247 2996 1675 2640 3511 1968 105 145 077Greater Bay Area 2566 3373 1952 3579 4639 2764 080 - -San Francisco-Oakland 2570 3403 1940 3701 4820 2843 080 - -San Jose-Monterey 2568 3324 1985 3370 4325 2632 - - -

Los Angeles 1365 1887 973 1717 2377 1214 106 178 060Greater California 2541 3359 1912 2744 3629 2057 115 120 113

Connecticut 2054 2649 1624 2228 2835 1786 098 - -Detroit 1793 2287 1472 2350 2889 2011 080 - 087Georgia 2664 3566 2027 3712 4737 2968 105 105 105Atlanta 2765 3781 2083 4681 5955 3807 083 090 076Rural Georgia 2289 2973 1793 3332 3936 2834 - - -Greater Georgia 2625 3487 2002 3355 4320 2638 118 103 128

Hawaii 2140 2809 1590 6609 8167 5068 - - -Idaho 2791 3299 2386 2881 3395 2471 - - -Iowa 2632 3043 2378 2657 3048 2423 - - -Kentucky 2687 3339 2250 2847 3513 2398 147 - -Louisiana 1728 2399 1242 2413 3227 1805 099 105 094Massachusetts 2116 2622 1768 2206 2712 1862 067 - -New Jersey 2186 2831 1738 2603 3314 2108 094 109 086New Mexico 1533 1961 1186 1625 2073 1257 - - -New York 1810 2323 1455 2287 2866 1880 097 107 090Seattle-Puget Sound 2864 3478 2417 3334 3972 2869 - - -Utah 3976 4980 3149 4132 5150 3293 - - -

SEER 9 Areasb 2481 3140 1999 3094 3827 2558 088 092 086SEER 13 Areasb 2228 2868 1756 2805 3546 2254 094 115 080SEER 18 Areasb 2322 3024 1805 2788 3577 2202 102 114 095SEER 21 Areasb 2225 2880 1749 2663 3393 2128 100 110 093

Table 1616Melanoma of the Skin (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 229 349 135 288 436 170 029 041 -Greater Bay Area 195 306 110 278 433 157 - - -San Francisco-Oakland 203 321 113 297 467 164 - - -San Jose-Monterey 179 276 103 245 374 143 - - -

Los Angeles 160 243 096 214 324 128 - - -Greater California 273 412 163 319 480 191 031 - -

Connecticut 217 320 142 240 348 159 - - -Detroit 196 297 123 248 372 156 035 - -Georgia 244 382 141 325 498 189 038 035 038Atlanta 181 265 122 279 396 189 036 - -Rural Georgia 197 - - 277 - - - - -Greater Georgia 275 437 152 344 536 191 038 - -

Hawaii 162 251 092 436 667 218 - - -Idaho 338 462 229 345 468 236 - - -Iowa 275 381 192 282 390 196 - - -Kentucky 308 466 189 331 497 204 - - -Louisiana 203 306 131 262 395 164 049 - 052Massachusetts 262 381 177 288 414 196 - - -New Jersey 228 344 145 276 411 177 - - -New Mexico 247 363 158 265 391 167 - - -New York 199 295 129 248 364 160 028 030 026Seattle-Puget Sound 272 402 167 312 456 193 - - -Utah 328 504 182 343 525 192 - - -

SEER 9 Areasb 231 346 144 284 421 178 038 049 031SEER 13 Areasb 212 319 131 268 398 166 035 048 027SEER 18 Areasb 237 358 144 290 435 177 035 041 030SEER 21 Areasb 233 350 145 284 422 177 033 039 028

Total US 249 372 155 290 428 181 036 044 030

Table 1617Melanoma of the Skin (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 249 001

High Five StatesIdaho 338 020 01(0116) 3594c

Utah 328 017 02(0117) 3192c

West Virginia 318 017 03(0124) 2768c

Kentucky 308 011 04(0118) 2377c

Kansas 300 014 05(0128) 2049c

Low Five StatesTexas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c

New York 199 004 49(4450) -2017c

Hawaii 162 014 50(4750) -3489c

DC 082 017 51(5151) -6697c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 263 010 24(0839) 573 Montana 281 022 13(0145) 1272Alaska 260 033 28(0150) 430 Nebraska 283 017 11(0138) 1371Arizona 279 009 17(0530) 1201 Nevada 270 014 22(0440) 848Arkansas 249 012 32(1045) 012 New Hampshire 267 019 23(0245) 741California 229 003 41(3446) -812 New Jersey 228 007 42(3147) -831Colorado 287 011 09(0329) 1531c New Mexico 247 015 33(0947) -093Connecticut 217 010 45(3249) -1286 New York 199 004 49(4450) -2017c

Delaware 284 023 10(0145) 1387 North Carolina 258 007 29(1437) 377DC 082 017 51(5151) -6697c North Dakota 215 023 46(1150) -1381Florida 271 005 21(1129) 892 Ohio 279 006 16(0628) 1207Georgia 244 007 34(2144) -195 Oklahoma 293 012 07(0227) 1777c

Hawaii 162 014 50(4750) -3489c Oregon 277 011 18(0334) 1133Idaho 338 020 01(0116) 3594c Pennsylvania 260 006 27(1536) 432Illinois 237 006 38(2845) -471 Rhode Island 240 019 36(0649) -363Indiana 275 009 20(0632) 1044 South Carolina 239 009 37(2146) -386Iowa 275 012 19(0337) 1055 South Dakota 230 022 40(0750) -751Kansas 300 014 05(0128) 2049c Tennessee 299 009 06(0121) 1993c

Kentucky 308 011 04(0118) 2377c Texas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c Utah 328 017 02(0117) 3192c

Maine 280 018 14(0142) 1245 Vermont 262 026 26(0149) 518Maryland 223 008 44(3149) -1037 Virginia 256 008 30(1440) 279Massachusetts 262 008 25(1037) 526 Washington 279 009 15(0430) 1209Michigan 233 006 39(2846) -640 West Virginia 318 017 03(0124) 2768c

Minnesota 242 009 35(2145) -274 Wisconsin 255 009 31(1341) 224Mississippi 228 012 43(2249) -838 Wyoming 281 030 12(0149) 1275Missouri 287 009 08(0327) 1544c

Table 1618Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 372 002

High Five StatesUtah 504 031 01(0113) 3567c

Tennessee 478 018 02(0111) 2845c

West Virginia 470 031 03(0130) 2649c

Kentucky 466 021 04(0117) 2526c

Idaho 462 034 05(0134) 2433c

Low Five StatesTexas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c

New York 295 008 49(4350) -2062c

Hawaii 251 025 50(4151) -3244c

DC 148 035 51(5051) -6008c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 401 019 17(0439) 783 Montana 414 038 10(0147) 1146Alaska 379 062 30(0150) 197 Nebraska 414 030 11(0143) 1132Arizona 399 015 18(0636) 730 Nevada 406 024 14(0342) 919Arkansas 380 022 29(0646) 220 New Hampshire 399 035 19(0148) 727California 349 006 38(3044) -622 New Jersey 344 013 41(2547) -760Colorado 405 019 15(0438) 888 New Mexico 363 026 34(0749) -247Connecticut 320 019 46(2750) -1396 New York 295 008 49(4350) -2062c

Delaware 394 040 21(0149) 587 North Carolina 391 013 22(0837) 517DC 148 035 51(5051) -6008c North Dakota 339 043 43(0350) -889Florida 409 008 13(0727) 1003 Ohio 409 012 12(0631) 1005Georgia 382 014 26(0941) 282 Oklahoma 443 022 06(0128) 1925c

Hawaii 251 025 50(4151) -3244c Oregon 388 019 25(0644) 423Idaho 462 034 05(0134) 2433c Pennsylvania 374 010 32(1541) 069Illinois 350 011 37(2446) -600 Rhode Island 322 035 45(0950) -1329Indiana 396 016 20(0738) 650 South Carolina 348 018 39(1648) -637Iowa 381 022 27(0645) 258 South Dakota 330 039 44(0550) -1131Kansas 439 025 07(0132) 1807c Tennessee 478 018 02(0111) 2845c

Kentucky 466 021 04(0117) 2526c Texas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c Utah 504 031 01(0113) 3567c

Maine 388 031 24(0248) 424 Vermont 356 045 35(0150) -426Maryland 355 016 36(1547) -458 Virginia 389 014 23(0739) 469Massachusetts 381 015 28(1042) 235 Washington 402 016 16(0535) 806Michigan 343 012 42(2647) -783 West Virginia 470 031 03(0130) 2649c

Minnesota 345 016 40(2148) -720 Wisconsin 378 016 31(0943) 175Mississippi 365 024 33(0848) -177 Wyoming 424 055 09(0149) 1413Missouri 438 017 08(0224) 1785c

Table 1619Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 155 001

High Five StatesIdaho 229 023 01(0127) 4774c

Delaware 202 027 02(0144) 3043c

West Virginia 196 018 03(0138) 2695c

Maine 195 021 04(0143) 2582c

Colorado 194 012 05(0128) 2563c

Low Five StatesNew York 129 005 46(3749) -1691c

Maryland 129 009 47(3050) -1695c

Texas 124 004 48(4050) -1996c

North Dakota 105 023 49(1450) -3186c

Hawaii 092 014 50(4050) -4037c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 162 011 27(0644) 439 Montana 157 023 32(0150) 156Alaska 171 035 22(0150) 1044 Nebraska 179 018 15(0145) 1576c

Arizona 178 010 16(0335) 1524c Nevada 146 014 39(0849) -537Arkansas 147 013 37(0849) -508 New Hampshire 171 020 23(0148) 1020California 135 004 43(3547) -1246 New Jersey 145 007 40(2347) -611Colorado 194 012 05(0128) 2563c New Mexico 158 016 30(0349) 234Connecticut 142 011 41(1649) -833 New York 129 005 46(3749) -1691c

Delaware 202 027 02(0144) 3043c North Carolina 163 007 25(0939) 554DC - - -(--) - North Dakota 105 023 49(1450) -3186c

Florida 160 005 28(1638) 349 Ohio 180 007 14(0329) 1607c

Georgia 141 007 42(2549) -868 Oklahoma 173 013 20(0241) 1179Hawaii 092 014 50(4050) -4037c Oregon 189 013 08(0134) 2214c

Idaho 229 023 01(0127) 4774c Pennsylvania 175 007 19(0532) 1331Illinois 153 006 35(1843) -106 Rhode Island 184 022 10(0148) 1888c

Indiana 180 010 13(0234) 1612c South Carolina 159 010 29(0845) 300Iowa 192 014 07(0134) 2427c South Dakota 149 025 36(0150) -395Kansas 193 015 06(0135) 2496c Tennessee 164 009 24(0641) 594Kentucky 189 012 09(0133) 2194c Texas 124 004 48(4050) -1996c

Louisiana 131 010 45(2650) -1543c Utah 182 017 11(0143) 1790c

Maine 195 021 04(0143) 2582c Vermont 180 029 12(0149) 1612c

Maryland 129 009 47(3050) -1695c Virginia 155 008 34(1345) 046Massachusetts 177 009 18(0336) 1414 Washington 177 009 17(0335) 1441Michigan 147 007 38(2146) -514 West Virginia 196 018 03(0138) 2695c

Minnesota 162 010 26(0644) 472 Wisconsin 156 009 33(1146) 060Mississippi 131 012 44(2050) -1541c Wyoming 158 030 31(0150) 198Missouri 171 010 21(0439) 1056

Table 1620Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex All Races Both Sexes 340956 252815 188823 141530 79525 1003650 191958 1195608

Males 191955 135055 95771 69992 37823 530596 80562 611158Females 149001 117760 93052 71538 41703 473054 111397 584451

White Both Sexes 322955 243898 182478 134944 75013 959288 187178 1183599Males 182373 130757 92628 66932 35701 508391 79164 606511Females 140583 113140 89850 68011 39313 450897 108015 577088

Black Both Sexes 1210 817 583 521 306 3437 518 3955Males 543 357 246 204 181 1531 238 1769Females 667 459 337 317 126 1906 281 2186

Asian Both Sexes 1037 645 549 390 151 2772 + +Pacific Males 503 286 214 153 67 1223 + +Islander Females 534 359 335 238 84 1549 + +

Hispanic Both Sexes 7370 4706 3769 2800 1400 20045 + +Males 3099 1935 1178 980 464 7655 + +Females 4271 2772 2591 1820 936 12390 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 03115 00004 00028 00272 01112 02434 04490 07350 11135 13328 02713

Males 03345 00003 00025 00185 00749 01879 04233 08607 15266 20883 03122Females 02892 00006 00032 00363 01477 02980 04736 06212 07693 08681 02449

White Both Sexes 03804 00005 00034 00337 01372 02949 05285 08476 12565 14827 03142Males 04069 00004 00030 00229 00916 02232 04920 09822 17036 23064 03547Females 03544 00006 00039 00451 01843 03673 05640 07228 08759 09669 02892

Black Both Sexes 00076 - 00005 00006 00044 00068 00113 00205 00395 00556 00088Males 00071 - 00003 00005 00026 00047 00098 00236 00477 00851 00097Females 00081 - 00008 00007 00060 00086 00126 00180 00338 00410 00085

Asian Both Sexes 00136 00006 00011 00025 00068 00143 00244 00345 00489 00657 00141Pacific Males 00125 - 00008 00024 00060 00114 00209 00364 00582 00775 00142Islander Females 00146 00011 00013 00027 00075 00170 00274 00329 00415 00582 00142

Hispanic Both Sexes 00351 00002 00012 00048 00188 00438 00841 01385 01969 02490 00500Males 00265 00002 00008 00033 00100 00251 00587 01211 02071 03352 00450Females 00439 00002 00017 00064 00282 00631 01092 01539 01891 01958 00562

Table 1621Melanoma of the Skin (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2012-2016

California 2247 2996 1675 2640 3511 1968 105 145 077Greater Bay Area 2566 3373 1952 3579 4639 2764 080 - -San Francisco-Oakland 2570 3403 1940 3701 4820 2843 080 - -San Jose-Monterey 2568 3324 1985 3370 4325 2632 - - -

Los Angeles 1365 1887 973 1717 2377 1214 106 178 060Greater California 2541 3359 1912 2744 3629 2057 115 120 113

Connecticut 2054 2649 1624 2228 2835 1786 098 - -Detroit 1793 2287 1472 2350 2889 2011 080 - 087Georgia 2664 3566 2027 3712 4737 2968 105 105 105Atlanta 2765 3781 2083 4681 5955 3807 083 090 076Rural Georgia 2289 2973 1793 3332 3936 2834 - - -Greater Georgia 2625 3487 2002 3355 4320 2638 118 103 128

Hawaii 2140 2809 1590 6609 8167 5068 - - -Idaho 2791 3299 2386 2881 3395 2471 - - -Iowa 2632 3043 2378 2657 3048 2423 - - -Kentucky 2687 3339 2250 2847 3513 2398 147 - -Louisiana 1728 2399 1242 2413 3227 1805 099 105 094Massachusetts 2116 2622 1768 2206 2712 1862 067 - -New Jersey 2186 2831 1738 2603 3314 2108 094 109 086New Mexico 1533 1961 1186 1625 2073 1257 - - -New York 1810 2323 1455 2287 2866 1880 097 107 090Seattle-Puget Sound 2864 3478 2417 3334 3972 2869 - - -Utah 3976 4980 3149 4132 5150 3293 - - -

SEER 9 Areasb 2481 3140 1999 3094 3827 2558 088 092 086SEER 13 Areasb 2228 2868 1756 2805 3546 2254 094 115 080SEER 18 Areasb 2322 3024 1805 2788 3577 2202 102 114 095SEER 21 Areasb 2225 2880 1749 2663 3393 2128 100 110 093

Table 1616Melanoma of the Skin (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 229 349 135 288 436 170 029 041 -Greater Bay Area 195 306 110 278 433 157 - - -San Francisco-Oakland 203 321 113 297 467 164 - - -San Jose-Monterey 179 276 103 245 374 143 - - -

Los Angeles 160 243 096 214 324 128 - - -Greater California 273 412 163 319 480 191 031 - -

Connecticut 217 320 142 240 348 159 - - -Detroit 196 297 123 248 372 156 035 - -Georgia 244 382 141 325 498 189 038 035 038Atlanta 181 265 122 279 396 189 036 - -Rural Georgia 197 - - 277 - - - - -Greater Georgia 275 437 152 344 536 191 038 - -

Hawaii 162 251 092 436 667 218 - - -Idaho 338 462 229 345 468 236 - - -Iowa 275 381 192 282 390 196 - - -Kentucky 308 466 189 331 497 204 - - -Louisiana 203 306 131 262 395 164 049 - 052Massachusetts 262 381 177 288 414 196 - - -New Jersey 228 344 145 276 411 177 - - -New Mexico 247 363 158 265 391 167 - - -New York 199 295 129 248 364 160 028 030 026Seattle-Puget Sound 272 402 167 312 456 193 - - -Utah 328 504 182 343 525 192 - - -

SEER 9 Areasb 231 346 144 284 421 178 038 049 031SEER 13 Areasb 212 319 131 268 398 166 035 048 027SEER 18 Areasb 237 358 144 290 435 177 035 041 030SEER 21 Areasb 233 350 145 284 422 177 033 039 028

Total US 249 372 155 290 428 181 036 044 030

Table 1617Melanoma of the Skin (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 249 001

High Five StatesIdaho 338 020 01(0116) 3594c

Utah 328 017 02(0117) 3192c

West Virginia 318 017 03(0124) 2768c

Kentucky 308 011 04(0118) 2377c

Kansas 300 014 05(0128) 2049c

Low Five StatesTexas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c

New York 199 004 49(4450) -2017c

Hawaii 162 014 50(4750) -3489c

DC 082 017 51(5151) -6697c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 263 010 24(0839) 573 Montana 281 022 13(0145) 1272Alaska 260 033 28(0150) 430 Nebraska 283 017 11(0138) 1371Arizona 279 009 17(0530) 1201 Nevada 270 014 22(0440) 848Arkansas 249 012 32(1045) 012 New Hampshire 267 019 23(0245) 741California 229 003 41(3446) -812 New Jersey 228 007 42(3147) -831Colorado 287 011 09(0329) 1531c New Mexico 247 015 33(0947) -093Connecticut 217 010 45(3249) -1286 New York 199 004 49(4450) -2017c

Delaware 284 023 10(0145) 1387 North Carolina 258 007 29(1437) 377DC 082 017 51(5151) -6697c North Dakota 215 023 46(1150) -1381Florida 271 005 21(1129) 892 Ohio 279 006 16(0628) 1207Georgia 244 007 34(2144) -195 Oklahoma 293 012 07(0227) 1777c

Hawaii 162 014 50(4750) -3489c Oregon 277 011 18(0334) 1133Idaho 338 020 01(0116) 3594c Pennsylvania 260 006 27(1536) 432Illinois 237 006 38(2845) -471 Rhode Island 240 019 36(0649) -363Indiana 275 009 20(0632) 1044 South Carolina 239 009 37(2146) -386Iowa 275 012 19(0337) 1055 South Dakota 230 022 40(0750) -751Kansas 300 014 05(0128) 2049c Tennessee 299 009 06(0121) 1993c

Kentucky 308 011 04(0118) 2377c Texas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c Utah 328 017 02(0117) 3192c

Maine 280 018 14(0142) 1245 Vermont 262 026 26(0149) 518Maryland 223 008 44(3149) -1037 Virginia 256 008 30(1440) 279Massachusetts 262 008 25(1037) 526 Washington 279 009 15(0430) 1209Michigan 233 006 39(2846) -640 West Virginia 318 017 03(0124) 2768c

Minnesota 242 009 35(2145) -274 Wisconsin 255 009 31(1341) 224Mississippi 228 012 43(2249) -838 Wyoming 281 030 12(0149) 1275Missouri 287 009 08(0327) 1544c

Table 1618Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 372 002

High Five StatesUtah 504 031 01(0113) 3567c

Tennessee 478 018 02(0111) 2845c

West Virginia 470 031 03(0130) 2649c

Kentucky 466 021 04(0117) 2526c

Idaho 462 034 05(0134) 2433c

Low Five StatesTexas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c

New York 295 008 49(4350) -2062c

Hawaii 251 025 50(4151) -3244c

DC 148 035 51(5051) -6008c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 401 019 17(0439) 783 Montana 414 038 10(0147) 1146Alaska 379 062 30(0150) 197 Nebraska 414 030 11(0143) 1132Arizona 399 015 18(0636) 730 Nevada 406 024 14(0342) 919Arkansas 380 022 29(0646) 220 New Hampshire 399 035 19(0148) 727California 349 006 38(3044) -622 New Jersey 344 013 41(2547) -760Colorado 405 019 15(0438) 888 New Mexico 363 026 34(0749) -247Connecticut 320 019 46(2750) -1396 New York 295 008 49(4350) -2062c

Delaware 394 040 21(0149) 587 North Carolina 391 013 22(0837) 517DC 148 035 51(5051) -6008c North Dakota 339 043 43(0350) -889Florida 409 008 13(0727) 1003 Ohio 409 012 12(0631) 1005Georgia 382 014 26(0941) 282 Oklahoma 443 022 06(0128) 1925c

Hawaii 251 025 50(4151) -3244c Oregon 388 019 25(0644) 423Idaho 462 034 05(0134) 2433c Pennsylvania 374 010 32(1541) 069Illinois 350 011 37(2446) -600 Rhode Island 322 035 45(0950) -1329Indiana 396 016 20(0738) 650 South Carolina 348 018 39(1648) -637Iowa 381 022 27(0645) 258 South Dakota 330 039 44(0550) -1131Kansas 439 025 07(0132) 1807c Tennessee 478 018 02(0111) 2845c

Kentucky 466 021 04(0117) 2526c Texas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c Utah 504 031 01(0113) 3567c

Maine 388 031 24(0248) 424 Vermont 356 045 35(0150) -426Maryland 355 016 36(1547) -458 Virginia 389 014 23(0739) 469Massachusetts 381 015 28(1042) 235 Washington 402 016 16(0535) 806Michigan 343 012 42(2647) -783 West Virginia 470 031 03(0130) 2649c

Minnesota 345 016 40(2148) -720 Wisconsin 378 016 31(0943) 175Mississippi 365 024 33(0848) -177 Wyoming 424 055 09(0149) 1413Missouri 438 017 08(0224) 1785c

Table 1619Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 155 001

High Five StatesIdaho 229 023 01(0127) 4774c

Delaware 202 027 02(0144) 3043c

West Virginia 196 018 03(0138) 2695c

Maine 195 021 04(0143) 2582c

Colorado 194 012 05(0128) 2563c

Low Five StatesNew York 129 005 46(3749) -1691c

Maryland 129 009 47(3050) -1695c

Texas 124 004 48(4050) -1996c

North Dakota 105 023 49(1450) -3186c

Hawaii 092 014 50(4050) -4037c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 162 011 27(0644) 439 Montana 157 023 32(0150) 156Alaska 171 035 22(0150) 1044 Nebraska 179 018 15(0145) 1576c

Arizona 178 010 16(0335) 1524c Nevada 146 014 39(0849) -537Arkansas 147 013 37(0849) -508 New Hampshire 171 020 23(0148) 1020California 135 004 43(3547) -1246 New Jersey 145 007 40(2347) -611Colorado 194 012 05(0128) 2563c New Mexico 158 016 30(0349) 234Connecticut 142 011 41(1649) -833 New York 129 005 46(3749) -1691c

Delaware 202 027 02(0144) 3043c North Carolina 163 007 25(0939) 554DC - - -(--) - North Dakota 105 023 49(1450) -3186c

Florida 160 005 28(1638) 349 Ohio 180 007 14(0329) 1607c

Georgia 141 007 42(2549) -868 Oklahoma 173 013 20(0241) 1179Hawaii 092 014 50(4050) -4037c Oregon 189 013 08(0134) 2214c

Idaho 229 023 01(0127) 4774c Pennsylvania 175 007 19(0532) 1331Illinois 153 006 35(1843) -106 Rhode Island 184 022 10(0148) 1888c

Indiana 180 010 13(0234) 1612c South Carolina 159 010 29(0845) 300Iowa 192 014 07(0134) 2427c South Dakota 149 025 36(0150) -395Kansas 193 015 06(0135) 2496c Tennessee 164 009 24(0641) 594Kentucky 189 012 09(0133) 2194c Texas 124 004 48(4050) -1996c

Louisiana 131 010 45(2650) -1543c Utah 182 017 11(0143) 1790c

Maine 195 021 04(0143) 2582c Vermont 180 029 12(0149) 1612c

Maryland 129 009 47(3050) -1695c Virginia 155 008 34(1345) 046Massachusetts 177 009 18(0336) 1414 Washington 177 009 17(0335) 1441Michigan 147 007 38(2146) -514 West Virginia 196 018 03(0138) 2695c

Minnesota 162 010 26(0644) 472 Wisconsin 156 009 33(1146) 060Mississippi 131 012 44(2050) -1541c Wyoming 158 030 31(0150) 198Missouri 171 010 21(0439) 1056

Table 1620Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex All Races Both Sexes 340956 252815 188823 141530 79525 1003650 191958 1195608

Males 191955 135055 95771 69992 37823 530596 80562 611158Females 149001 117760 93052 71538 41703 473054 111397 584451

White Both Sexes 322955 243898 182478 134944 75013 959288 187178 1183599Males 182373 130757 92628 66932 35701 508391 79164 606511Females 140583 113140 89850 68011 39313 450897 108015 577088

Black Both Sexes 1210 817 583 521 306 3437 518 3955Males 543 357 246 204 181 1531 238 1769Females 667 459 337 317 126 1906 281 2186

Asian Both Sexes 1037 645 549 390 151 2772 + +Pacific Males 503 286 214 153 67 1223 + +Islander Females 534 359 335 238 84 1549 + +

Hispanic Both Sexes 7370 4706 3769 2800 1400 20045 + +Males 3099 1935 1178 980 464 7655 + +Females 4271 2772 2591 1820 936 12390 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 03115 00004 00028 00272 01112 02434 04490 07350 11135 13328 02713

Males 03345 00003 00025 00185 00749 01879 04233 08607 15266 20883 03122Females 02892 00006 00032 00363 01477 02980 04736 06212 07693 08681 02449

White Both Sexes 03804 00005 00034 00337 01372 02949 05285 08476 12565 14827 03142Males 04069 00004 00030 00229 00916 02232 04920 09822 17036 23064 03547Females 03544 00006 00039 00451 01843 03673 05640 07228 08759 09669 02892

Black Both Sexes 00076 - 00005 00006 00044 00068 00113 00205 00395 00556 00088Males 00071 - 00003 00005 00026 00047 00098 00236 00477 00851 00097Females 00081 - 00008 00007 00060 00086 00126 00180 00338 00410 00085

Asian Both Sexes 00136 00006 00011 00025 00068 00143 00244 00345 00489 00657 00141Pacific Males 00125 - 00008 00024 00060 00114 00209 00364 00582 00775 00142Islander Females 00146 00011 00013 00027 00075 00170 00274 00329 00415 00582 00142

Hispanic Both Sexes 00351 00002 00012 00048 00188 00438 00841 01385 01969 02490 00500Males 00265 00002 00008 00033 00100 00251 00587 01211 02071 03352 00450Females 00439 00002 00017 00064 00282 00631 01092 01539 01891 01958 00562

Table 1621Melanoma of the Skin (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2012-2016

California 229 349 135 288 436 170 029 041 -Greater Bay Area 195 306 110 278 433 157 - - -San Francisco-Oakland 203 321 113 297 467 164 - - -San Jose-Monterey 179 276 103 245 374 143 - - -

Los Angeles 160 243 096 214 324 128 - - -Greater California 273 412 163 319 480 191 031 - -

Connecticut 217 320 142 240 348 159 - - -Detroit 196 297 123 248 372 156 035 - -Georgia 244 382 141 325 498 189 038 035 038Atlanta 181 265 122 279 396 189 036 - -Rural Georgia 197 - - 277 - - - - -Greater Georgia 275 437 152 344 536 191 038 - -

Hawaii 162 251 092 436 667 218 - - -Idaho 338 462 229 345 468 236 - - -Iowa 275 381 192 282 390 196 - - -Kentucky 308 466 189 331 497 204 - - -Louisiana 203 306 131 262 395 164 049 - 052Massachusetts 262 381 177 288 414 196 - - -New Jersey 228 344 145 276 411 177 - - -New Mexico 247 363 158 265 391 167 - - -New York 199 295 129 248 364 160 028 030 026Seattle-Puget Sound 272 402 167 312 456 193 - - -Utah 328 504 182 343 525 192 - - -

SEER 9 Areasb 231 346 144 284 421 178 038 049 031SEER 13 Areasb 212 319 131 268 398 166 035 048 027SEER 18 Areasb 237 358 144 290 435 177 035 041 030SEER 21 Areasb 233 350 145 284 422 177 033 039 028

Total US 249 372 155 290 428 181 036 044 030

Table 1617Melanoma of the Skin (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 249 001

High Five StatesIdaho 338 020 01(0116) 3594c

Utah 328 017 02(0117) 3192c

West Virginia 318 017 03(0124) 2768c

Kentucky 308 011 04(0118) 2377c

Kansas 300 014 05(0128) 2049c

Low Five StatesTexas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c

New York 199 004 49(4450) -2017c

Hawaii 162 014 50(4750) -3489c

DC 082 017 51(5151) -6697c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 263 010 24(0839) 573 Montana 281 022 13(0145) 1272Alaska 260 033 28(0150) 430 Nebraska 283 017 11(0138) 1371Arizona 279 009 17(0530) 1201 Nevada 270 014 22(0440) 848Arkansas 249 012 32(1045) 012 New Hampshire 267 019 23(0245) 741California 229 003 41(3446) -812 New Jersey 228 007 42(3147) -831Colorado 287 011 09(0329) 1531c New Mexico 247 015 33(0947) -093Connecticut 217 010 45(3249) -1286 New York 199 004 49(4450) -2017c

Delaware 284 023 10(0145) 1387 North Carolina 258 007 29(1437) 377DC 082 017 51(5151) -6697c North Dakota 215 023 46(1150) -1381Florida 271 005 21(1129) 892 Ohio 279 006 16(0628) 1207Georgia 244 007 34(2144) -195 Oklahoma 293 012 07(0227) 1777c

Hawaii 162 014 50(4750) -3489c Oregon 277 011 18(0334) 1133Idaho 338 020 01(0116) 3594c Pennsylvania 260 006 27(1536) 432Illinois 237 006 38(2845) -471 Rhode Island 240 019 36(0649) -363Indiana 275 009 20(0632) 1044 South Carolina 239 009 37(2146) -386Iowa 275 012 19(0337) 1055 South Dakota 230 022 40(0750) -751Kansas 300 014 05(0128) 2049c Tennessee 299 009 06(0121) 1993c

Kentucky 308 011 04(0118) 2377c Texas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c Utah 328 017 02(0117) 3192c

Maine 280 018 14(0142) 1245 Vermont 262 026 26(0149) 518Maryland 223 008 44(3149) -1037 Virginia 256 008 30(1440) 279Massachusetts 262 008 25(1037) 526 Washington 279 009 15(0430) 1209Michigan 233 006 39(2846) -640 West Virginia 318 017 03(0124) 2768c

Minnesota 242 009 35(2145) -274 Wisconsin 255 009 31(1341) 224Mississippi 228 012 43(2249) -838 Wyoming 281 030 12(0149) 1275Missouri 287 009 08(0327) 1544c

Table 1618Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 372 002

High Five StatesUtah 504 031 01(0113) 3567c

Tennessee 478 018 02(0111) 2845c

West Virginia 470 031 03(0130) 2649c

Kentucky 466 021 04(0117) 2526c

Idaho 462 034 05(0134) 2433c

Low Five StatesTexas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c

New York 295 008 49(4350) -2062c

Hawaii 251 025 50(4151) -3244c

DC 148 035 51(5051) -6008c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 401 019 17(0439) 783 Montana 414 038 10(0147) 1146Alaska 379 062 30(0150) 197 Nebraska 414 030 11(0143) 1132Arizona 399 015 18(0636) 730 Nevada 406 024 14(0342) 919Arkansas 380 022 29(0646) 220 New Hampshire 399 035 19(0148) 727California 349 006 38(3044) -622 New Jersey 344 013 41(2547) -760Colorado 405 019 15(0438) 888 New Mexico 363 026 34(0749) -247Connecticut 320 019 46(2750) -1396 New York 295 008 49(4350) -2062c

Delaware 394 040 21(0149) 587 North Carolina 391 013 22(0837) 517DC 148 035 51(5051) -6008c North Dakota 339 043 43(0350) -889Florida 409 008 13(0727) 1003 Ohio 409 012 12(0631) 1005Georgia 382 014 26(0941) 282 Oklahoma 443 022 06(0128) 1925c

Hawaii 251 025 50(4151) -3244c Oregon 388 019 25(0644) 423Idaho 462 034 05(0134) 2433c Pennsylvania 374 010 32(1541) 069Illinois 350 011 37(2446) -600 Rhode Island 322 035 45(0950) -1329Indiana 396 016 20(0738) 650 South Carolina 348 018 39(1648) -637Iowa 381 022 27(0645) 258 South Dakota 330 039 44(0550) -1131Kansas 439 025 07(0132) 1807c Tennessee 478 018 02(0111) 2845c

Kentucky 466 021 04(0117) 2526c Texas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c Utah 504 031 01(0113) 3567c

Maine 388 031 24(0248) 424 Vermont 356 045 35(0150) -426Maryland 355 016 36(1547) -458 Virginia 389 014 23(0739) 469Massachusetts 381 015 28(1042) 235 Washington 402 016 16(0535) 806Michigan 343 012 42(2647) -783 West Virginia 470 031 03(0130) 2649c

Minnesota 345 016 40(2148) -720 Wisconsin 378 016 31(0943) 175Mississippi 365 024 33(0848) -177 Wyoming 424 055 09(0149) 1413Missouri 438 017 08(0224) 1785c

Table 1619Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 155 001

High Five StatesIdaho 229 023 01(0127) 4774c

Delaware 202 027 02(0144) 3043c

West Virginia 196 018 03(0138) 2695c

Maine 195 021 04(0143) 2582c

Colorado 194 012 05(0128) 2563c

Low Five StatesNew York 129 005 46(3749) -1691c

Maryland 129 009 47(3050) -1695c

Texas 124 004 48(4050) -1996c

North Dakota 105 023 49(1450) -3186c

Hawaii 092 014 50(4050) -4037c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 162 011 27(0644) 439 Montana 157 023 32(0150) 156Alaska 171 035 22(0150) 1044 Nebraska 179 018 15(0145) 1576c

Arizona 178 010 16(0335) 1524c Nevada 146 014 39(0849) -537Arkansas 147 013 37(0849) -508 New Hampshire 171 020 23(0148) 1020California 135 004 43(3547) -1246 New Jersey 145 007 40(2347) -611Colorado 194 012 05(0128) 2563c New Mexico 158 016 30(0349) 234Connecticut 142 011 41(1649) -833 New York 129 005 46(3749) -1691c

Delaware 202 027 02(0144) 3043c North Carolina 163 007 25(0939) 554DC - - -(--) - North Dakota 105 023 49(1450) -3186c

Florida 160 005 28(1638) 349 Ohio 180 007 14(0329) 1607c

Georgia 141 007 42(2549) -868 Oklahoma 173 013 20(0241) 1179Hawaii 092 014 50(4050) -4037c Oregon 189 013 08(0134) 2214c

Idaho 229 023 01(0127) 4774c Pennsylvania 175 007 19(0532) 1331Illinois 153 006 35(1843) -106 Rhode Island 184 022 10(0148) 1888c

Indiana 180 010 13(0234) 1612c South Carolina 159 010 29(0845) 300Iowa 192 014 07(0134) 2427c South Dakota 149 025 36(0150) -395Kansas 193 015 06(0135) 2496c Tennessee 164 009 24(0641) 594Kentucky 189 012 09(0133) 2194c Texas 124 004 48(4050) -1996c

Louisiana 131 010 45(2650) -1543c Utah 182 017 11(0143) 1790c

Maine 195 021 04(0143) 2582c Vermont 180 029 12(0149) 1612c

Maryland 129 009 47(3050) -1695c Virginia 155 008 34(1345) 046Massachusetts 177 009 18(0336) 1414 Washington 177 009 17(0335) 1441Michigan 147 007 38(2146) -514 West Virginia 196 018 03(0138) 2695c

Minnesota 162 010 26(0644) 472 Wisconsin 156 009 33(1146) 060Mississippi 131 012 44(2050) -1541c Wyoming 158 030 31(0150) 198Missouri 171 010 21(0439) 1056

Table 1620Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex All Races Both Sexes 340956 252815 188823 141530 79525 1003650 191958 1195608

Males 191955 135055 95771 69992 37823 530596 80562 611158Females 149001 117760 93052 71538 41703 473054 111397 584451

White Both Sexes 322955 243898 182478 134944 75013 959288 187178 1183599Males 182373 130757 92628 66932 35701 508391 79164 606511Females 140583 113140 89850 68011 39313 450897 108015 577088

Black Both Sexes 1210 817 583 521 306 3437 518 3955Males 543 357 246 204 181 1531 238 1769Females 667 459 337 317 126 1906 281 2186

Asian Both Sexes 1037 645 549 390 151 2772 + +Pacific Males 503 286 214 153 67 1223 + +Islander Females 534 359 335 238 84 1549 + +

Hispanic Both Sexes 7370 4706 3769 2800 1400 20045 + +Males 3099 1935 1178 980 464 7655 + +Females 4271 2772 2591 1820 936 12390 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 03115 00004 00028 00272 01112 02434 04490 07350 11135 13328 02713

Males 03345 00003 00025 00185 00749 01879 04233 08607 15266 20883 03122Females 02892 00006 00032 00363 01477 02980 04736 06212 07693 08681 02449

White Both Sexes 03804 00005 00034 00337 01372 02949 05285 08476 12565 14827 03142Males 04069 00004 00030 00229 00916 02232 04920 09822 17036 23064 03547Females 03544 00006 00039 00451 01843 03673 05640 07228 08759 09669 02892

Black Both Sexes 00076 - 00005 00006 00044 00068 00113 00205 00395 00556 00088Males 00071 - 00003 00005 00026 00047 00098 00236 00477 00851 00097Females 00081 - 00008 00007 00060 00086 00126 00180 00338 00410 00085

Asian Both Sexes 00136 00006 00011 00025 00068 00143 00244 00345 00489 00657 00141Pacific Males 00125 - 00008 00024 00060 00114 00209 00364 00582 00775 00142Islander Females 00146 00011 00013 00027 00075 00170 00274 00329 00415 00582 00142

Hispanic Both Sexes 00351 00002 00012 00048 00188 00438 00841 01385 01969 02490 00500Males 00265 00002 00008 00033 00100 00251 00587 01211 02071 03352 00450Females 00439 00002 00017 00064 00282 00631 01092 01539 01891 01958 00562

Table 1621Melanoma of the Skin (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 249 001

High Five StatesIdaho 338 020 01(0116) 3594c

Utah 328 017 02(0117) 3192c

West Virginia 318 017 03(0124) 2768c

Kentucky 308 011 04(0118) 2377c

Kansas 300 014 05(0128) 2049c

Low Five StatesTexas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c

New York 199 004 49(4450) -2017c

Hawaii 162 014 50(4750) -3489c

DC 082 017 51(5151) -6697c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 263 010 24(0839) 573 Montana 281 022 13(0145) 1272Alaska 260 033 28(0150) 430 Nebraska 283 017 11(0138) 1371Arizona 279 009 17(0530) 1201 Nevada 270 014 22(0440) 848Arkansas 249 012 32(1045) 012 New Hampshire 267 019 23(0245) 741California 229 003 41(3446) -812 New Jersey 228 007 42(3147) -831Colorado 287 011 09(0329) 1531c New Mexico 247 015 33(0947) -093Connecticut 217 010 45(3249) -1286 New York 199 004 49(4450) -2017c

Delaware 284 023 10(0145) 1387 North Carolina 258 007 29(1437) 377DC 082 017 51(5151) -6697c North Dakota 215 023 46(1150) -1381Florida 271 005 21(1129) 892 Ohio 279 006 16(0628) 1207Georgia 244 007 34(2144) -195 Oklahoma 293 012 07(0227) 1777c

Hawaii 162 014 50(4750) -3489c Oregon 277 011 18(0334) 1133Idaho 338 020 01(0116) 3594c Pennsylvania 260 006 27(1536) 432Illinois 237 006 38(2845) -471 Rhode Island 240 019 36(0649) -363Indiana 275 009 20(0632) 1044 South Carolina 239 009 37(2146) -386Iowa 275 012 19(0337) 1055 South Dakota 230 022 40(0750) -751Kansas 300 014 05(0128) 2049c Tennessee 299 009 06(0121) 1993c

Kentucky 308 011 04(0118) 2377c Texas 208 004 47(4249) -1651c

Louisiana 203 009 48(4050) -1847c Utah 328 017 02(0117) 3192c

Maine 280 018 14(0142) 1245 Vermont 262 026 26(0149) 518Maryland 223 008 44(3149) -1037 Virginia 256 008 30(1440) 279Massachusetts 262 008 25(1037) 526 Washington 279 009 15(0430) 1209Michigan 233 006 39(2846) -640 West Virginia 318 017 03(0124) 2768c

Minnesota 242 009 35(2145) -274 Wisconsin 255 009 31(1341) 224Mississippi 228 012 43(2249) -838 Wyoming 281 030 12(0149) 1275Missouri 287 009 08(0327) 1544c

Table 1618Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males and Females

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 372 002

High Five StatesUtah 504 031 01(0113) 3567c

Tennessee 478 018 02(0111) 2845c

West Virginia 470 031 03(0130) 2649c

Kentucky 466 021 04(0117) 2526c

Idaho 462 034 05(0134) 2433c

Low Five StatesTexas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c

New York 295 008 49(4350) -2062c

Hawaii 251 025 50(4151) -3244c

DC 148 035 51(5051) -6008c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 401 019 17(0439) 783 Montana 414 038 10(0147) 1146Alaska 379 062 30(0150) 197 Nebraska 414 030 11(0143) 1132Arizona 399 015 18(0636) 730 Nevada 406 024 14(0342) 919Arkansas 380 022 29(0646) 220 New Hampshire 399 035 19(0148) 727California 349 006 38(3044) -622 New Jersey 344 013 41(2547) -760Colorado 405 019 15(0438) 888 New Mexico 363 026 34(0749) -247Connecticut 320 019 46(2750) -1396 New York 295 008 49(4350) -2062c

Delaware 394 040 21(0149) 587 North Carolina 391 013 22(0837) 517DC 148 035 51(5051) -6008c North Dakota 339 043 43(0350) -889Florida 409 008 13(0727) 1003 Ohio 409 012 12(0631) 1005Georgia 382 014 26(0941) 282 Oklahoma 443 022 06(0128) 1925c

Hawaii 251 025 50(4151) -3244c Oregon 388 019 25(0644) 423Idaho 462 034 05(0134) 2433c Pennsylvania 374 010 32(1541) 069Illinois 350 011 37(2446) -600 Rhode Island 322 035 45(0950) -1329Indiana 396 016 20(0738) 650 South Carolina 348 018 39(1648) -637Iowa 381 022 27(0645) 258 South Dakota 330 039 44(0550) -1131Kansas 439 025 07(0132) 1807c Tennessee 478 018 02(0111) 2845c

Kentucky 466 021 04(0117) 2526c Texas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c Utah 504 031 01(0113) 3567c

Maine 388 031 24(0248) 424 Vermont 356 045 35(0150) -426Maryland 355 016 36(1547) -458 Virginia 389 014 23(0739) 469Massachusetts 381 015 28(1042) 235 Washington 402 016 16(0535) 806Michigan 343 012 42(2647) -783 West Virginia 470 031 03(0130) 2649c

Minnesota 345 016 40(2148) -720 Wisconsin 378 016 31(0943) 175Mississippi 365 024 33(0848) -177 Wyoming 424 055 09(0149) 1413Missouri 438 017 08(0224) 1785c

Table 1619Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 155 001

High Five StatesIdaho 229 023 01(0127) 4774c

Delaware 202 027 02(0144) 3043c

West Virginia 196 018 03(0138) 2695c

Maine 195 021 04(0143) 2582c

Colorado 194 012 05(0128) 2563c

Low Five StatesNew York 129 005 46(3749) -1691c

Maryland 129 009 47(3050) -1695c

Texas 124 004 48(4050) -1996c

North Dakota 105 023 49(1450) -3186c

Hawaii 092 014 50(4050) -4037c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 162 011 27(0644) 439 Montana 157 023 32(0150) 156Alaska 171 035 22(0150) 1044 Nebraska 179 018 15(0145) 1576c

Arizona 178 010 16(0335) 1524c Nevada 146 014 39(0849) -537Arkansas 147 013 37(0849) -508 New Hampshire 171 020 23(0148) 1020California 135 004 43(3547) -1246 New Jersey 145 007 40(2347) -611Colorado 194 012 05(0128) 2563c New Mexico 158 016 30(0349) 234Connecticut 142 011 41(1649) -833 New York 129 005 46(3749) -1691c

Delaware 202 027 02(0144) 3043c North Carolina 163 007 25(0939) 554DC - - -(--) - North Dakota 105 023 49(1450) -3186c

Florida 160 005 28(1638) 349 Ohio 180 007 14(0329) 1607c

Georgia 141 007 42(2549) -868 Oklahoma 173 013 20(0241) 1179Hawaii 092 014 50(4050) -4037c Oregon 189 013 08(0134) 2214c

Idaho 229 023 01(0127) 4774c Pennsylvania 175 007 19(0532) 1331Illinois 153 006 35(1843) -106 Rhode Island 184 022 10(0148) 1888c

Indiana 180 010 13(0234) 1612c South Carolina 159 010 29(0845) 300Iowa 192 014 07(0134) 2427c South Dakota 149 025 36(0150) -395Kansas 193 015 06(0135) 2496c Tennessee 164 009 24(0641) 594Kentucky 189 012 09(0133) 2194c Texas 124 004 48(4050) -1996c

Louisiana 131 010 45(2650) -1543c Utah 182 017 11(0143) 1790c

Maine 195 021 04(0143) 2582c Vermont 180 029 12(0149) 1612c

Maryland 129 009 47(3050) -1695c Virginia 155 008 34(1345) 046Massachusetts 177 009 18(0336) 1414 Washington 177 009 17(0335) 1441Michigan 147 007 38(2146) -514 West Virginia 196 018 03(0138) 2695c

Minnesota 162 010 26(0644) 472 Wisconsin 156 009 33(1146) 060Mississippi 131 012 44(2050) -1541c Wyoming 158 030 31(0150) 198Missouri 171 010 21(0439) 1056

Table 1620Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex All Races Both Sexes 340956 252815 188823 141530 79525 1003650 191958 1195608

Males 191955 135055 95771 69992 37823 530596 80562 611158Females 149001 117760 93052 71538 41703 473054 111397 584451

White Both Sexes 322955 243898 182478 134944 75013 959288 187178 1183599Males 182373 130757 92628 66932 35701 508391 79164 606511Females 140583 113140 89850 68011 39313 450897 108015 577088

Black Both Sexes 1210 817 583 521 306 3437 518 3955Males 543 357 246 204 181 1531 238 1769Females 667 459 337 317 126 1906 281 2186

Asian Both Sexes 1037 645 549 390 151 2772 + +Pacific Males 503 286 214 153 67 1223 + +Islander Females 534 359 335 238 84 1549 + +

Hispanic Both Sexes 7370 4706 3769 2800 1400 20045 + +Males 3099 1935 1178 980 464 7655 + +Females 4271 2772 2591 1820 936 12390 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 03115 00004 00028 00272 01112 02434 04490 07350 11135 13328 02713

Males 03345 00003 00025 00185 00749 01879 04233 08607 15266 20883 03122Females 02892 00006 00032 00363 01477 02980 04736 06212 07693 08681 02449

White Both Sexes 03804 00005 00034 00337 01372 02949 05285 08476 12565 14827 03142Males 04069 00004 00030 00229 00916 02232 04920 09822 17036 23064 03547Females 03544 00006 00039 00451 01843 03673 05640 07228 08759 09669 02892

Black Both Sexes 00076 - 00005 00006 00044 00068 00113 00205 00395 00556 00088Males 00071 - 00003 00005 00026 00047 00098 00236 00477 00851 00097Females 00081 - 00008 00007 00060 00086 00126 00180 00338 00410 00085

Asian Both Sexes 00136 00006 00011 00025 00068 00143 00244 00345 00489 00657 00141Pacific Males 00125 - 00008 00024 00060 00114 00209 00364 00582 00775 00142Islander Females 00146 00011 00013 00027 00075 00170 00274 00329 00415 00582 00142

Hispanic Both Sexes 00351 00002 00012 00048 00188 00438 00841 01385 01969 02490 00500Males 00265 00002 00008 00033 00100 00251 00587 01211 02071 03352 00450Females 00439 00002 00017 00064 00282 00631 01092 01539 01891 01958 00562

Table 1621Melanoma of the Skin (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 372 002

High Five StatesUtah 504 031 01(0113) 3567c

Tennessee 478 018 02(0111) 2845c

West Virginia 470 031 03(0130) 2649c

Kentucky 466 021 04(0117) 2526c

Idaho 462 034 05(0134) 2433c

Low Five StatesTexas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c

New York 295 008 49(4350) -2062c

Hawaii 251 025 50(4151) -3244c

DC 148 035 51(5051) -6008c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 401 019 17(0439) 783 Montana 414 038 10(0147) 1146Alaska 379 062 30(0150) 197 Nebraska 414 030 11(0143) 1132Arizona 399 015 18(0636) 730 Nevada 406 024 14(0342) 919Arkansas 380 022 29(0646) 220 New Hampshire 399 035 19(0148) 727California 349 006 38(3044) -622 New Jersey 344 013 41(2547) -760Colorado 405 019 15(0438) 888 New Mexico 363 026 34(0749) -247Connecticut 320 019 46(2750) -1396 New York 295 008 49(4350) -2062c

Delaware 394 040 21(0149) 587 North Carolina 391 013 22(0837) 517DC 148 035 51(5051) -6008c North Dakota 339 043 43(0350) -889Florida 409 008 13(0727) 1003 Ohio 409 012 12(0631) 1005Georgia 382 014 26(0941) 282 Oklahoma 443 022 06(0128) 1925c

Hawaii 251 025 50(4151) -3244c Oregon 388 019 25(0644) 423Idaho 462 034 05(0134) 2433c Pennsylvania 374 010 32(1541) 069Illinois 350 011 37(2446) -600 Rhode Island 322 035 45(0950) -1329Indiana 396 016 20(0738) 650 South Carolina 348 018 39(1648) -637Iowa 381 022 27(0645) 258 South Dakota 330 039 44(0550) -1131Kansas 439 025 07(0132) 1807c Tennessee 478 018 02(0111) 2845c

Kentucky 466 021 04(0117) 2526c Texas 317 008 47(3949) -1468Louisiana 306 018 48(3350) -1765c Utah 504 031 01(0113) 3567c

Maine 388 031 24(0248) 424 Vermont 356 045 35(0150) -426Maryland 355 016 36(1547) -458 Virginia 389 014 23(0739) 469Massachusetts 381 015 28(1042) 235 Washington 402 016 16(0535) 806Michigan 343 012 42(2647) -783 West Virginia 470 031 03(0130) 2649c

Minnesota 345 016 40(2148) -720 Wisconsin 378 016 31(0943) 175Mississippi 365 024 33(0848) -177 Wyoming 424 055 09(0149) 1413Missouri 438 017 08(0224) 1785c

Table 1619Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Males

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 155 001

High Five StatesIdaho 229 023 01(0127) 4774c

Delaware 202 027 02(0144) 3043c

West Virginia 196 018 03(0138) 2695c

Maine 195 021 04(0143) 2582c

Colorado 194 012 05(0128) 2563c

Low Five StatesNew York 129 005 46(3749) -1691c

Maryland 129 009 47(3050) -1695c

Texas 124 004 48(4050) -1996c

North Dakota 105 023 49(1450) -3186c

Hawaii 092 014 50(4050) -4037c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 162 011 27(0644) 439 Montana 157 023 32(0150) 156Alaska 171 035 22(0150) 1044 Nebraska 179 018 15(0145) 1576c

Arizona 178 010 16(0335) 1524c Nevada 146 014 39(0849) -537Arkansas 147 013 37(0849) -508 New Hampshire 171 020 23(0148) 1020California 135 004 43(3547) -1246 New Jersey 145 007 40(2347) -611Colorado 194 012 05(0128) 2563c New Mexico 158 016 30(0349) 234Connecticut 142 011 41(1649) -833 New York 129 005 46(3749) -1691c

Delaware 202 027 02(0144) 3043c North Carolina 163 007 25(0939) 554DC - - -(--) - North Dakota 105 023 49(1450) -3186c

Florida 160 005 28(1638) 349 Ohio 180 007 14(0329) 1607c

Georgia 141 007 42(2549) -868 Oklahoma 173 013 20(0241) 1179Hawaii 092 014 50(4050) -4037c Oregon 189 013 08(0134) 2214c

Idaho 229 023 01(0127) 4774c Pennsylvania 175 007 19(0532) 1331Illinois 153 006 35(1843) -106 Rhode Island 184 022 10(0148) 1888c

Indiana 180 010 13(0234) 1612c South Carolina 159 010 29(0845) 300Iowa 192 014 07(0134) 2427c South Dakota 149 025 36(0150) -395Kansas 193 015 06(0135) 2496c Tennessee 164 009 24(0641) 594Kentucky 189 012 09(0133) 2194c Texas 124 004 48(4050) -1996c

Louisiana 131 010 45(2650) -1543c Utah 182 017 11(0143) 1790c

Maine 195 021 04(0143) 2582c Vermont 180 029 12(0149) 1612c

Maryland 129 009 47(3050) -1695c Virginia 155 008 34(1345) 046Massachusetts 177 009 18(0336) 1414 Washington 177 009 17(0335) 1441Michigan 147 007 38(2146) -514 West Virginia 196 018 03(0138) 2695c

Minnesota 162 010 26(0644) 472 Wisconsin 156 009 33(1146) 060Mississippi 131 012 44(2050) -1541c Wyoming 158 030 31(0150) 198Missouri 171 010 21(0439) 1056

Table 1620Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex All Races Both Sexes 340956 252815 188823 141530 79525 1003650 191958 1195608

Males 191955 135055 95771 69992 37823 530596 80562 611158Females 149001 117760 93052 71538 41703 473054 111397 584451

White Both Sexes 322955 243898 182478 134944 75013 959288 187178 1183599Males 182373 130757 92628 66932 35701 508391 79164 606511Females 140583 113140 89850 68011 39313 450897 108015 577088

Black Both Sexes 1210 817 583 521 306 3437 518 3955Males 543 357 246 204 181 1531 238 1769Females 667 459 337 317 126 1906 281 2186

Asian Both Sexes 1037 645 549 390 151 2772 + +Pacific Males 503 286 214 153 67 1223 + +Islander Females 534 359 335 238 84 1549 + +

Hispanic Both Sexes 7370 4706 3769 2800 1400 20045 + +Males 3099 1935 1178 980 464 7655 + +Females 4271 2772 2591 1820 936 12390 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 03115 00004 00028 00272 01112 02434 04490 07350 11135 13328 02713

Males 03345 00003 00025 00185 00749 01879 04233 08607 15266 20883 03122Females 02892 00006 00032 00363 01477 02980 04736 06212 07693 08681 02449

White Both Sexes 03804 00005 00034 00337 01372 02949 05285 08476 12565 14827 03142Males 04069 00004 00030 00229 00916 02232 04920 09822 17036 23064 03547Females 03544 00006 00039 00451 01843 03673 05640 07228 08759 09669 02892

Black Both Sexes 00076 - 00005 00006 00044 00068 00113 00205 00395 00556 00088Males 00071 - 00003 00005 00026 00047 00098 00236 00477 00851 00097Females 00081 - 00008 00007 00060 00086 00126 00180 00338 00410 00085

Asian Both Sexes 00136 00006 00011 00025 00068 00143 00244 00345 00489 00657 00141Pacific Males 00125 - 00008 00024 00060 00114 00209 00364 00582 00775 00142Islander Females 00146 00011 00013 00027 00075 00170 00274 00329 00415 00582 00142

Hispanic Both Sexes 00351 00002 00012 00048 00188 00438 00841 01385 01969 02490 00500Males 00265 00002 00008 00033 00100 00251 00587 01211 02071 03352 00450Females 00439 00002 00017 00064 00282 00631 01092 01539 01891 01958 00562

Table 1621Melanoma of the Skin (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 155 001

High Five StatesIdaho 229 023 01(0127) 4774c

Delaware 202 027 02(0144) 3043c

West Virginia 196 018 03(0138) 2695c

Maine 195 021 04(0143) 2582c

Colorado 194 012 05(0128) 2563c

Low Five StatesNew York 129 005 46(3749) -1691c

Maryland 129 009 47(3050) -1695c

Texas 124 004 48(4050) -1996c

North Dakota 105 023 49(1450) -3186c

Hawaii 092 014 50(4050) -4037c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 162 011 27(0644) 439 Montana 157 023 32(0150) 156Alaska 171 035 22(0150) 1044 Nebraska 179 018 15(0145) 1576c

Arizona 178 010 16(0335) 1524c Nevada 146 014 39(0849) -537Arkansas 147 013 37(0849) -508 New Hampshire 171 020 23(0148) 1020California 135 004 43(3547) -1246 New Jersey 145 007 40(2347) -611Colorado 194 012 05(0128) 2563c New Mexico 158 016 30(0349) 234Connecticut 142 011 41(1649) -833 New York 129 005 46(3749) -1691c

Delaware 202 027 02(0144) 3043c North Carolina 163 007 25(0939) 554DC - - -(--) - North Dakota 105 023 49(1450) -3186c

Florida 160 005 28(1638) 349 Ohio 180 007 14(0329) 1607c

Georgia 141 007 42(2549) -868 Oklahoma 173 013 20(0241) 1179Hawaii 092 014 50(4050) -4037c Oregon 189 013 08(0134) 2214c

Idaho 229 023 01(0127) 4774c Pennsylvania 175 007 19(0532) 1331Illinois 153 006 35(1843) -106 Rhode Island 184 022 10(0148) 1888c

Indiana 180 010 13(0234) 1612c South Carolina 159 010 29(0845) 300Iowa 192 014 07(0134) 2427c South Dakota 149 025 36(0150) -395Kansas 193 015 06(0135) 2496c Tennessee 164 009 24(0641) 594Kentucky 189 012 09(0133) 2194c Texas 124 004 48(4050) -1996c

Louisiana 131 010 45(2650) -1543c Utah 182 017 11(0143) 1790c

Maine 195 021 04(0143) 2582c Vermont 180 029 12(0149) 1612c

Maryland 129 009 47(3050) -1695c Virginia 155 008 34(1345) 046Massachusetts 177 009 18(0336) 1414 Washington 177 009 17(0335) 1441Michigan 147 007 38(2146) -514 West Virginia 196 018 03(0138) 2695c

Minnesota 162 010 26(0644) 472 Wisconsin 156 009 33(1146) 060Mississippi 131 012 44(2050) -1541c Wyoming 158 030 31(0150) 198Missouri 171 010 21(0439) 1056

Table 1620Melanoma of the Skin (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2012-2016

Females

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex All Races Both Sexes 340956 252815 188823 141530 79525 1003650 191958 1195608

Males 191955 135055 95771 69992 37823 530596 80562 611158Females 149001 117760 93052 71538 41703 473054 111397 584451

White Both Sexes 322955 243898 182478 134944 75013 959288 187178 1183599Males 182373 130757 92628 66932 35701 508391 79164 606511Females 140583 113140 89850 68011 39313 450897 108015 577088

Black Both Sexes 1210 817 583 521 306 3437 518 3955Males 543 357 246 204 181 1531 238 1769Females 667 459 337 317 126 1906 281 2186

Asian Both Sexes 1037 645 549 390 151 2772 + +Pacific Males 503 286 214 153 67 1223 + +Islander Females 534 359 335 238 84 1549 + +

Hispanic Both Sexes 7370 4706 3769 2800 1400 20045 + +Males 3099 1935 1178 980 464 7655 + +Females 4271 2772 2591 1820 936 12390 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 03115 00004 00028 00272 01112 02434 04490 07350 11135 13328 02713

Males 03345 00003 00025 00185 00749 01879 04233 08607 15266 20883 03122Females 02892 00006 00032 00363 01477 02980 04736 06212 07693 08681 02449

White Both Sexes 03804 00005 00034 00337 01372 02949 05285 08476 12565 14827 03142Males 04069 00004 00030 00229 00916 02232 04920 09822 17036 23064 03547Females 03544 00006 00039 00451 01843 03673 05640 07228 08759 09669 02892

Black Both Sexes 00076 - 00005 00006 00044 00068 00113 00205 00395 00556 00088Males 00071 - 00003 00005 00026 00047 00098 00236 00477 00851 00097Females 00081 - 00008 00007 00060 00086 00126 00180 00338 00410 00085

Asian Both Sexes 00136 00006 00011 00025 00068 00143 00244 00345 00489 00657 00141Pacific Males 00125 - 00008 00024 00060 00114 00209 00364 00582 00775 00142Islander Females 00146 00011 00013 00027 00075 00170 00274 00329 00415 00582 00142

Hispanic Both Sexes 00351 00002 00012 00048 00188 00438 00841 01385 01969 02490 00500Males 00265 00002 00008 00033 00100 00251 00587 01211 02071 03352 00450Females 00439 00002 00017 00064 00282 00631 01092 01539 01891 01958 00562

Table 1621Melanoma of the Skin (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

a US 2016 cancer prevalence counts are based on 2016 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112016 US population estimates based on the average of 2015 and 2016 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 24 years

b Maximum limited-duration prevalence is 24 years for 1992-2016 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 24 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing 0 to lt24 and gt=24- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to lt5 5 to lt10 10 to lt15 15 to lt20 20 to lt24 0 to lt24b gt=24d Completee

Race Sex All Races Both Sexes 340956 252815 188823 141530 79525 1003650 191958 1195608

Males 191955 135055 95771 69992 37823 530596 80562 611158Females 149001 117760 93052 71538 41703 473054 111397 584451

White Both Sexes 322955 243898 182478 134944 75013 959288 187178 1183599Males 182373 130757 92628 66932 35701 508391 79164 606511Females 140583 113140 89850 68011 39313 450897 108015 577088

Black Both Sexes 1210 817 583 521 306 3437 518 3955Males 543 357 246 204 181 1531 238 1769Females 667 459 337 317 126 1906 281 2186

Asian Both Sexes 1037 645 549 390 151 2772 + +Pacific Males 503 286 214 153 67 1223 + +Islander Females 534 359 335 238 84 1549 + +

Hispanic Both Sexes 7370 4706 3769 2800 1400 20045 + +Males 3099 1935 1178 980 464 7655 + +Females 4271 2772 2591 1820 936 12390 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 03115 00004 00028 00272 01112 02434 04490 07350 11135 13328 02713

Males 03345 00003 00025 00185 00749 01879 04233 08607 15266 20883 03122Females 02892 00006 00032 00363 01477 02980 04736 06212 07693 08681 02449

White Both Sexes 03804 00005 00034 00337 01372 02949 05285 08476 12565 14827 03142Males 04069 00004 00030 00229 00916 02232 04920 09822 17036 23064 03547Females 03544 00006 00039 00451 01843 03673 05640 07228 08759 09669 02892

Black Both Sexes 00076 - 00005 00006 00044 00068 00113 00205 00395 00556 00088Males 00071 - 00003 00005 00026 00047 00098 00236 00477 00851 00097Females 00081 - 00008 00007 00060 00086 00126 00180 00338 00410 00085

Asian Both Sexes 00136 00006 00011 00025 00068 00143 00244 00345 00489 00657 00141Pacific Males 00125 - 00008 00024 00060 00114 00209 00364 00582 00775 00142Islander Females 00146 00011 00013 00027 00075 00170 00274 00329 00415 00582 00142

Hispanic Both Sexes 00351 00002 00012 00048 00188 00438 00841 01385 01969 02490 00500Males 00265 00002 00008 00033 00100 00251 00587 01211 02071 03352 00450Females 00439 00002 00017 00064 00282 00631 01092 01539 01891 01958 00562

Table 1621Melanoma of the Skin (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2016By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2016 of the SEER population diagnosed in the previous 24 yearsBy Age at Prevalence RaceEthnicity and Sex

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

0

5

10

15

20

25

30

35

40

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

40

1975 1985 1995 2005 2016

Delay-Adjusted IncidenceDelay-Adjusted Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesMelanoma of the Skin White by Sex

a

Figure 161

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

Male FemaleRate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 2005-16 = 19Observed 2005-16 = 16

US Mortality APC2014-16 = -83

SEER Incidence APCsDelay Adj 2012-16 = 36Observed 2005-16 = 17

US Mortality APC2013-16 = -57

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

Joinpoint Analyses for Whites and Blacks from 1975-2016and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2016

0

5

10

15

20

25

30

35

1975 1985 1995 2005 20160

5

10

15

20

25

30

35

1975 1985 1995 2005 2016

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesMelanoma of the Skin Both Sexes

Figure 162

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 47 February 2019 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2016 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2016 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

0

50

100

150

200

250

0-4 5-9 10-14 15-19 20-24 25-29 30-34 35-39 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85+

Males 2014-2016

Males 2004-2006

Females 2014-2016

Females 2004-2006

Figure 163

Melanoma of the SkinSEER Incidence 2004-2006 vs 2014-2016

White by Age and Sex

Source SEER 13 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey Los Angeles Alaska Native Registry and Rural Georgia) Rates are age-adjusted as appropriate to the 2000 US Std Population (19 age groups - Census P25-1103)

Rate per 100000

Age at Diagnosis

SEE

R C

ancer Statistics Review

1975-2016N

ational Cancer Institute

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival

Figure 164

Melanoma of the Skin5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2016 National Cancer Institute

• Trends in SEER Incidence and US Mortality Both Sexes
• Trends in SEER Incidence and US Mortality Males
• Trends in SEER Incidence and US Mortality Females
• Annual Delay-adjusted Incidence Rates
• Annual Incidence Rates
• Annual Death Rates
• Incidence and Mortality Rates by Age
• 5-year Relative and Period Survival
• Relative Survival by Year of Diagnosis Both Sexes
• Relative Survival by Year of Diagnosis Males
• Relative Survival by Year of Diagnosis Females
• Risk of DevelopingDying Both Sexes
• Risk of DevelopingDying Males
• Risk of DevelopingDying Females
• Rates and Trends by RaceEthnicity
• Age-Adjusted SEER Incidence Rates by Registry
• Age-Adjusted SEER Death Rates by Registry
• Age-Adjusted Cancer Death Rates By State Both Sexes
• Age-Adjusted Cancer Death Rates By State Males
• Age-Adjusted Cancer Death Rates By State Females
• US Prevalence Estimates
• Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Sex
• Graph - SEER Incidence and US Death Rates by RaceEthnicity
• Graph - SEER Incidence by Age and Sex
• Graph - 5-Year SEER Conditional Relative Survival