searching the pharmacology literature
DESCRIPTION
Lecture given to Unit 8 (INDS 208) -- Pathobiology Treatment and Prevention of Disease -- in the undergraduate medical curriculum at McGill University on September 10, 2012.TRANSCRIPT
Searching the Pharmacology Literature
INDS 208: Pathobiology Treatment & Prevention of Disease
Robin Featherstone
Andrea Miller-Nesbitt
Objectives
By the end of this lecture, you will be able to:1. Describe the five phases of the drug life
cycle
2. Identify appropriate sources in which to find pharmaceutical information
3. Execute a search for drug information using subject headings, subheadings (where appropriate) and filters
4. Export citations to a RefWorks account and output a bibliography for an academic paper
Drug DiscoveryLab Research
5 K – 10 K potential drugs
2 – 10 years
Pre-Clinical Research(animal testing)
~250potential drugs
3 – 6 years
Clinical Trials
6 - 7 years
Review
1 approved drug
1 – 2 years
Ongoing Analysis
Review of side effects
Life of the drug
1.
1. http://hlwiki.slais.ubc.ca/images/e/ef/Drugapproval.gif
Health Canadawww.hc-sc.gc.ca
Drug Products Database
DatabasesPubMed
9505 titles
http://www.ncbi.nlm.nih.gov/projects/linkout/doc/lojournalsproviders.shtmlhttp://embase.com/info/what-is-embase/coverage
Embase
7687 titles
ACC Cardiosource Review Journal
Acta Toxicologica
Actualites Pharmaceutiques Hospitalieres
Advances in Hematology
American Journal of Biochemistry and Biotechnology
Cancer Cell International
Journal of Pharmacy Technology
Journal of Physiotherapy
Journal of the History of Biology
Journal of Translational Medicine
Journal of Clinical Bioinformatics
Biomagnetic Research and Technology
Conflict and Health
Gut Pathogens
International seminars in surgical oncology
Thyroid Research
Environmental Entomology
Database Subject areas Subject headings
How to export to RefWorks
PubMed Biomedicine and health care
Yes Save citations and import
Embase Biomedicine and pharmacology
Yes Direct export
SciFinder Chemistry and biochemistry
No Save citations and import
ClinicalTrials.gov Patient trials of interventions
No RefGrabIt
Database comparison
1. What is the molecular structure of Dronedarone? A. EMBASE
2. Which injection method is the most effective for administering lidocaine?
B. Clinical Trials.gov
3. What drug therapies are most effective for alcohol withdrawal in adolescence?
C. SciFinder
4. Where can you find information about patient recruitment for a study of enzyme use in celiac disease?
D. PubMed
What is the best source for these questions?
• Web-based citation management software
• Information on RefWorks: http://www.mcgill.ca/library/library-using/citationsoftware/refworks
• McGill group code: RWMcGillUni
• Request a RefWorks consult or ask a question: [email protected]
• Identify a target molecule• Find a promising “lead compound”• Determine pharmacokinetics
Drug DiscoveryDrug DiscoveryLab Research
5 K – 10 K potential drugs
2 – 10 years
What are the pharmacokinetics of orally administered anti-cancer drugs?
Drug DiscoveryDrug DiscoveryLab Research
5 K – 10 K potential drugs
2 – 10 years
Pharmacokinetics
Anti-cancer drugs
Administered orally
Audience Experts
Compare to NCBI Entrez
Cost Subscription (registration required)
Coverage Chemistry and biochemistry
URL http://scifinder.cas.org/
Drug DiscoveryLab Research
5 K – 10 K potential drugs
2 – 10 years
Pre-Clinical Research
You are interested in the research done on orexin antagonists for the treatment of insomnia.
Pre-Clinical Research(animal testing)
~250potential drugs
3 – 6 years
Pre-Clinical Research(animal testing)
~250potential drugs
3 – 6 years
Audience Experts
Compare to Web of Science
Cost Subscription
Coverage All subjects (science focus)
URL http://www.scopus.com/
Clinical Trials
You’re interested in therapeutic use of enzymes for patients with celiac disease.
Clinical Trials
6 - 7 years
How would you combine the terms for celiac disease and enzymes?
celiac disease
enzymes
celiac disease
enzymes
Celiac Disease OR Enzymes Clinical Trials
6 - 7 years
✗
celiac disease
enzymes
Celiac Disease AND Enzymes Clinical Trials
6 - 7 years
What’s missing from this search strategy?
✓
• Start with your first concept“celiac disease”
• Combine any synonyms with OR”celiac disease” OR “coeliac disease” OR “celiac sprue”
• Repeat for your second, or any subsequent concepts
enzyme* OR biocatalyst*
• Finally, group your concepts with brackets and combine with AND
(“celiac disease” OR “coeliac disease OR “celiac sprue”) AND (enzyme* OR biocatalyst*)
How to SearchClinical Trials
6 - 7 years
Clinical Trials
6 - 7 years
Audience Everyone
Compare to ISRCTN
Cost Free
Coverage Patient trials of interventions
URL http://clinicaltrials.gov/
Clinical Trials
You’re interested in therapeutic use of enzymes for patients with celiac disease.
Clinical Trials
6 - 7 years
What if you wanted to know more about the results from trials of oral enzyme therapy for patients with celiac disease?
Clinical Trials
6 - 7 years
Audience Experts
Compare to PubMed
Cost Subscription
Coverage Biomedicine and pharmacology
Training URL http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=main&D=oemezd
U/N & P/W mcgtrain & training
Drug Review
You’re interested in the availability of the new oral dose medication Gilenya (Fingolimod) for patients with relapsing remitting multiple sclerosis.
Review
1 approved drug
1 – 2 years
Where would you look to find information about approval of this drug in Canada?
Health Canadawww.hc-sc.gc.ca
Drug Products Database
Review
1 approved drug
1 – 2 years
Audience Everyone
Compare to eCPS
Cost Free
Coverage Drug product information / drug monographs
URL http://webprod3.hc-sc.gc.ca/dpd-bdpp/index-eng.jsp
Ongoing Analysis
You’re interested in rates of patient compliance with drug therapy post heart attack.
Ongoing Analysis
Review of side effects
Life of the drug
Where would you look to find studies on patient compliance?
Ongoing Analysis
Review of side effects
Life of the drug
Audience Experts
Compare to Embase
Cost Free
Coverage Biomedicine and health care
URL http://www.ncbi.nlm.nih.gov/sites/entrez?otool=icamuhslib
1. Where can you find administration and dosage information for a patient taking ampicillin for meningitis? 2. Which drug therapy for patients with type I diabetes is associated with the fewest adverse reactions?3. What is the molecular structure of tapentadol hydrochloride?4. What is the safest method of administering antibiotics to febrile infants?
What is the best source for these questions?
1. The 5 phases of the drug life cycle are …
2. A database that contains information about pre-clinical research is…
3. Combine synonymous terms with …
4. PubMed tools for finding pharmaceutical studies are …
5. Three methods for importing citations into RefWorks are…
SUMMARY QUIZ
Questions?
Robin Featherstone
Andrea Miller-Nesbitt
RefWorks help