Searching theChemical Literature

What types of information are in the literature?

Physical constants Melting point, boiling point, flash point, density, solubility

data, toxicity data, refractive index.

Synthesis pathways

Experimental procedures

Spectroscopy data FTIR, 1H-NMR, 13C-NMR, MS, UV-VIS

Background for research

Where search?

Google?

Reference books

Merck Index

CRC Handbook of Chemistry and Physics

March

The Merck Index

The Merck Index is a one-volume encyclopedia of chemicals, drugs and biologicals that contains more than 10,000 monographs. Each monograph in this authoritative reference source is a concise description of a single substance or a small group of closely related compounds.

Since it was first published in 1889, The Merck Index has become the standard reference for chemists, biochemists, pharmacologists, pharmacists, and related professionals.

The Merck Index Compounds included: human and veterinary drugs biotech drugs and monoclonal antibodies substances used for medical imaging biologicals and natural products plants and herbal medicines nutraceuticals and cosmeceuticals agricultural chemicals industrial chemicals laboratory reagents and catalysts dyes, colors and indicators environmentally significant substances

The Merck Index

Information provided:

chemical, common and generic names trademarks and associated companies CAS Registry Numbers chemical structures molecular formulae, weights and percentage

composition capsule statements identifying compound

classes and scientific significance

The Merck IndexInformation provided continued:

scientific and patent literature references physical and toxicity data therapeutic and commercial uses caution and hazard information In addition, there are Name, Formula, CAS Registry

Number, and Therapeutic Category and Biological Activity indices. The collection of supplementary tables contains physical, chemical and biomedical data and listings of pharmaceutical company names, locations and experimental drug codes. The Organic Name Reactions section contains over 400 reactions featuring descriptions, literature references and graphical depictions.

The Merck Index, 9th ed.

The Merck Index, 9th ed.

The Merck Index, 9th ed.

The Merck Index, 9th ed.

CRC Handbook of Chemistry and Physics

The Table of Physical Constants for Organic Compounds:

Listed in alphabetical order by parent name.

For 2-phenylethanol

Ethanol

-2-phenyl

CRC Handbook of Chemistry and Physics

The Table of Physical Constants for Organic Compounds:

Boiling points:

254760, 12434

CRC CRC Handbook of Handbook of Chemistry Chemistry

and Physics, and Physics, 11stst student student

editionedition

CRC CRC Handbook of Handbook of Chemistry Chemistry

and Physics, and Physics, 1st student 1st student

editionedition

March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure , 6th ed.

 

MarchMarch, 4, 4thth ed.ed.

March, March, 4th ed.4th ed.

Other sources…. Chemical Abstracts, Beilstein SciFinder Journal articles/Databases

ACS Publications Chemical and Engineering News

GALILEO (Current Contents: JACS, JOC) JStor (Science)

Primary = original Secondary = reviews, accounts

Chemfinder

May need to register yourself (free) to install plug-ins

ChemFinder

search using name, CAS number, molecular formula, MW

ChemACX Net

search using name or CAS number, or Advanced Query for

substructure or exact structure

Organic Synthesis

10 collective volumes, search using substructure, reaction,

keyword, name, CAS number, or volume

Spectroscopy websites

National Institute of Standards and Technology

Chemistry WebBook Mass Spectrometry and Infrared Spectroscopy data,

thermochemical data, and much, much more.

Spectral Data Base System for Organic Compounds

(SDBS) Huge searchable database of spectra, including IR, NMR,

and MS.

Safety Information

Vermont SIRI MSDS Collection Provides access to Material Safety Data Sheets

directly from chemical manufacturers and from an online database. Chemical Toxicity reports can also be found at this site.