sdl use cases

©2015 Cambridge Semantics Inc. All rights reserved.

Clinical Trial Site Intelligence (CTSI)An Anzo Smart Data Lake™ Solution


Life Sciences Use Case Clinical Trial Site Intelligence (CTSI)


Cambridge Semantics

Cambridge Semantics is the creator of the Anzo Smart Data Lake ™ (ASDL) Based on semantic web technology, the ASDL provides an end-to-end graph-based data integration, discovery, management, and analytics technology platform. Cambridge Semantics delivers Smart Data solutions for Life Science companies including R&D Intelligence, Scientific Affairs, Clinical Data Integration, clinical site selection, and much, much more… • Founded in 2007 by senior members of IBM’s Advanced Internet Technology Group• The Anzo software suite is built on World Wide Web Consortium (W3C) open data standards and 13+

years of R&D• The award-winning Anzo software suite is our 3rd generation implementation of semantic web

technologies


What is SMART Data?

RELATE ‘LIKE’ DATA

(contextualize)

EXPLORATO

RY ANALYTICS (graph-ware)

LINKED DATA (diverse sources)

LINKED DATA- Structured

(Relational DB, Excel, …)

- Semi-structured (XML, HTML, …)

- Unstructured (PDF, Word, email, …)

- Industry standard data structures (RDF)

EXPLORATORY ANALYTICS- Immediately query ALL the data in the graph DB- Simple self-service analytics with familiar Excel-like functions- Industry standard query structures (SPARQL)

RELATE ‘LIKE’ DATA- Associate related

concepts in a flexible & extensible graph DB

- Understand the data in a human-readable ontology

- Immediately operationalize the data in a machine-readable graph DB

- Industry standard data modeling (OWL)


On Tuesday, Drugs123 Inc. announced phase 1 development of their newest sleep aid therapeutic, Narcoleptol.

On Tuesday, Drugs123 Inc. announced phase 1 development of their newest sleep aid therapeutic, Narcoleptol.

Smart Data - Linked & Contextualized Data with Semantics

Company Website Mkt Cap

Bio Corp biocorp.com $2.2B

Drugs123 drugs123.com $930M

… … …

Competitive Company Database

Company

Drugs123

930,000,000

name

marketcap

drugs123.com

website

Web news

Drug Development

1

developmentstage

activityDrug

developing

Insomnia

indication

Narcoleptol

brandname

Intelligence Review System

Note

about

3/7/2012

Initial safety signals are …

when

note


Standards-based Smart Data

Semantic web technology built with World Wide Web Consortium (W3C) standards Scale & diversity of data on the web Ever-changing environments

Semantic web enables Smart Data by providing: RDF (Resource Description Framework) - A flexible and logical graph-based data model

that can consider data from any source => reduced development time and cost

OWL (Web Ontology Language) - An human understandable conceptual model of entities and relationships designed for business analysts and knowledge workers

=> improved application quality, iterative / investigative approach SPARQL – A complete, high-performance query language standard for accessing RDF data

where IT-intensive skills are not needed to access the underlying data structures => reduced development time and cost

W3C Open Standards – A backbone for industry-specific standards Benefit from industry standards e.g. CDISC, MedDRA, SNOMED, OpenPhacts …

=> improved data quality & interoperability


Exploratory Analytics (Graph-aware)


The Anzo Smart Data Platform™

An agile, end-to-end, platform for tackling diverse information challenges

Link and contextualize information for search, analytics, visualization and collaboration


The Anzo Smart Data Lake™

Data SourceIngestion

Link &Contextualize

Discovery Analytics

Insight Realization

Structured Unstructured

. . .

. . .

Anzo Smart DataIntegration (ASDI)

Anzo Smart Data Lake (ASDL) Server

Anzo Graph QueryEngine (AGQE)

Anzo on theWeb (AotW)

Company’sInformation Fabric

Semi-structured


Anzo Smart Data Lake™

Server

The Anzo Smart Data Lake™

Anzo Smart Data Integration

Server

Anzo Discovery and Analytics

Server

…..

Data Discovery and Analytics

Anzo Discovery and Analytics

Server

Anzo Smart Data Lake™

Server

Anzo Graph Query Engine….

Graph Storage and Cataloging

Integration - Ingestion and Linking


Server


Server

ExistingHadoop Data Lake

EnterpriseData Sources


Engi

neer

ing

Dem

onst

ratio

n

Anzo Smart Data Lake™ is “Big Data” Analytics

Early Adopters

0

20

40

60

80

100

120

Act

ive

RD

F Tr

iple

s (B

illio

ns)

Driving Insights from

“Big Data” Analytics


Sample Life Sciences Use Cases

• Clinical Data Standards Management - Manage the development integration of clinical metadata standards at multiple levels

• PV & Safety Data Management - Automated tagging of safety Case Report Forms (CRF) with customized curation workflow & text mining and contextual search

• R&D Competitive Intelligence – Explore the competitive landscape for Therapeutic Area, Indication, Target, Company, Compound, & Partners

• Clinical Trial Data Integration and Discovery - Create a semantic data lake for clinical trials within one or more Therapeutic Areas for analytics & decision support

• Real World Evidence (RWE) Driven Clinical Trials - Create a semantic data lake across clinical and healthcare EMR RWE for data analytics & decision support

• Clinical Trial Site Selection and Optimization - Clinical trial site selection, Key Opinion Leader (KOL) search & review, & trial site startup planning

• Scientific Affairs/Medical Science Liaisons - Track Key Opinion Leaders (KOL) in literature and clinical trials & analyze feedback from medical professionals and patients

• Information Landscape - Track and monitor data stewardship and usage through the organization to drive more efficient usage.

• Taxonomy Management - Blend taxonomies from different sources including versioning, de-duplication, & matching



ObjectiveIntegrate external curated global clinical trial subscription data, such as Citeline, Cortellis, PubMED, & CT.gov with internal operational site data to support site & Principal Investigators (PIs) selection and management. Provide a solution to capture site & PI operational experience data for wider company use. Provide high-value, reusable & controlled analytics for many users

Potential users: Power users: Site Selection (Clin Ops), Data Management, Clinical Study Teams Casual users: Clinical Operations, PV / Safety, Medical Affairs

Features BenefitsDiscover – Explore related Citeline, Cortellis, PubMED, & CT.gov content to identify PIs, Sites and Trials of interest

Access a single, unified source for global clinical trial data

Manage – Flexibly manage internal content of investigators and sites operational experience, capture Sponsor/CRO user feedback, curate (annotate) these data

Better site & PI selection & management using a single, unified source of industry & company operational clinical trial data

Analyze – Interactively analyze PIs and Site lists at all levels including Country, Site and TA.

Rapid answers to ‘what-if’ questions and data exploration: hours / days versus weeks / months



Roll-up, traverse, filter and visualize data across CTSI and Citeline

Trial

Investigator

SiteStatus

DiseaseAddressPatient

Segment

TA

Country

Organization

Phase

TrialtroveSitetroveCTSI

List Entry

Site List

Entry Site

User

SiteStatus

StatusFeedbackTierCategory…

Specialty



Demo


Life Sciences Use CaseClinical Trial Site Intelligence (CTSI)

Anzo Unstructured (AU) Pipeline Orchestrator & Monitor


Life Sciences Use CaseClinical Trial Site Intelligence (CTSI)

Demo

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