scientific report 2016 · gsk-fast track: the pis, mabel loza and Ángel carracedo, coordinators of...

Scientific Report 2016

INDEX

EXECUTIVE SUMMARY I-VIII

1. CENTER 3

a. Groups and Areas 3

b. New talent 4

c. Networks 5

2. SCIENTIFIC PRODUCTION 9

a. Papers 9

b. Books And Book Chapters 37

3. TECHNOLOGY TRASFER

a. Partnership with the industry 39

b. Spin-offs/Foundation/New Ventures 39

c. Patents 41

4. FINANCIAL RESOURCES 43

a. 2015 New Funding 43

b. 2015 Active 54

5. HUMAN RESOURCES 73

a. New 73

b. Visiting researchers 76

6. EDUCATION 79

a. Thesis 79

b. Conferences 82

c. Other activities 87

7. ACTIVITY 89

Executive Summary

I

EXECUTIVE SUMMARY

During the past year we have further pursue in refining our strategy towards the cutting edge

of knowledge in order to become international leaders at least in some research and

innovation areas. As a consequence of the work carry out over the past four years the Xunta

de Galicia open a call for accreditation of research centres in Galicia as “Centro Singular de

Investigación”. After assessment by independent reviewers they decided to grant the CiMUS,

as well as another 4 centres from the three Galician Universities, this status. This award was

associated to a relevant increase in our annual budget up to 2020. This will allow us to set up

in 2017 new schemes and actions in accordance with the new strategic plan. We have planned

a great number of measures, including attraction of talented people, greater emphasis in

training and internationalization, increase in actions and alliance with industrial partners. We

hope that this way we will further improve our scientific output and sustainability in the long

run.

HIGHLIGHTS 2016

1. SCIENTIFIC ACTIVITY

a. Human resources and talent´s recruitment:

In 2016 the CiMUS has incorporated 1 researcher from competitive calls: Miguel Fidalgo

as Researcher “Ramon y Cajal”. This researcher along with another researcher from the

same Program , Sulay Tovar, and two Associatte Professors at the USC , Noemi Csaba

and Marcos Fuentes, were enrolled as new PIs in the Center. “

The Campus Vida Research Centers Network organized in 2016 for first time its

International Postdoctoral Program with 3 postdoctoral positions offered, one for each

center. The applicant selected by CiMUS was Diana Guallar Artal.

The Biopharma group has incorporated a CSIC´s visiting professor, Juan Francisco López

Giménez , from the Institute of Biomedicine & Biotechnology of Cantabria that will stay

with us for two years.

In addittion from Postdocs´s competitive calls, Francesco Mainini, Henrique Rodrígues,

Marcelino, Eleni Samaridou, Noelia Martínez Sánchez, Mónica Imbernon Piedra and

Daniel Cacabelos Barral were incorporated as postdoctoral researchers at the CiMUS.

Finally, 21 new PhD Students were incorporated at the CiMUS groups to develop their

PhD projects.

II

HSR4R: As part of the USC, the CiMUS participate in the HRS4R strategy, a tool launched

by the European Commission to support universities, research institutions and

organizations that fund research in the application of The European Charter for

Researchers and The Code of Conduct for the Recruitment of Researchers, which aim to

contribute to the development of a European labor market attractive for researcher.

b. Financial resources:

International Projects: As previous years the main economic source of funding was

from EU- competitive programs, among all the international funding agencies. In

2016, twenty five of those projects were under development at the CiMUS reaching

49,15% of the budget. This year only 1 international project was started with new

funding. There are several projects originating from the EU Frame Program or

Horizon2020 as shown below:

NANO PILOT- María José Alonso

OPENPHACTS - Mabel Loza

B-CAST - Ángel Carracedo

IN-SENS – Jesús R. Requena

NABBA- María José Alonso

EUROFORGEN-NoE - Ángel Carracedo

ObERStress – Miguel López

NanoFar- María José Alonso

TRANS-INT- María José Alonso; Carlos Diéguez

OBESITY53 – Rubén Nogueiras

PanCanRisk - Ángel Carracedo

HELIX - Ángel Carracedo

FaBiMEd- José Ramón González Juanatey

CHAPRION- Jesús R Requna

EU-CaRE- José Ramón González Juanatey

B-SAMART- María José Alonso

PHYLOCANCER- Ángel Carracedo

NICHE- María José Alonso

III

National Projects: In 2016, 18 new projects were started, their funding coming

from National agencies, which together with other ongoing projects make up a

total of 50 active projects. Their financial impact means 28,42 % of the total budget.

Regional Projects: This year the regional government published a new call. At the

end of the year only the type D resolution had been published, with 5 projects from

CiMUS. Within this we had have 13 regional projects active and their financial

impact reached 10,24% of the CiMUS total budget.

Contracts and agreements: They were the 11,75% of the budget of the CiMUS in

2016. They represented the 18,27% of the new funding in 2016.

IV

c. Scientific production and excellence research

Scientific publications: In 2016, a total of 163 papers were published. Most of

them, 69,94%, were published at journals that belongs to the Q1, and inside of this

quartile, 22,09% were at D1.

A global analysis showed an IF accumulated of 847,488, with an average IF of 5,231.

A relevant number, 16,56%, were collaborations between different groups at the

CiMUS, being this figure higher than the previous year. Also the number of groups

involved in a particular paper is each year higher too. In some instances that meant

that scientist from three, four or five groups contribute to a single paper. A total of

18 papers were published by 2 groups, 6 by 3 groups, 2 by 4 groups and 1 by 5

groups

PhD Thesis: 37 Ph.D Thesis were defended by students that were under the

supervision of PIs at the CiMUS.

Stays: The CiMUS received 10 researchers from different groups outside the

University in order to develop projects or collaborations with our groups. Most of

them came from foreign countries like Colombia, Germany, Iran, UK or México.

In the other hand, 7 CiMUS researchers travelled to other institutions to develop

part of their projects there, in countries like Germany, Swittzerland, Belgium,

Portugal or USA.

International collaborations: 73 of the scientific publications were a collaborative

work with international groups, representing 44,79 % of all the papers published.

69,94%

V

d. Technology transfer:

Partnership with the Industry

Join Research Unit Biopharma-Esteve:This our current flagship of integrated

collaboration with the industry. The Unit participated in the development of

compounds that were licenced in 2016 by Esteve to an American Pharma and the

long standing collaboration between this Pharma with the group of drug discovery

at our Center is one of our major strengths.

Join Research Unit SunRock Biopharma-CiMUS: In July of 2016 we incorporate a

new Research Unit at the CIMUS. The aim is to develop new synergies and

opportunities. WE hope that in the next couple of years several projects will be

developed between this company with several groups at the CIMUS.

GSK-Fast Track: The PIs, Mabel Loza and Ángel Carracedo, coordinators of the

Innopharma Farmacogenomic Platform were selected by the Discovery

Partnerships with Academia Programe from GSK, as one of the 6 winners of the

Discovery Fast Track. They were selected in between 378 proposals from 21

countries all over Europe and North America.

Spin Offs/ Foundation/new ventures:

KERTOR Foundation: Follow-up of the INNOPHARMA project.

GenDR. This project is focused in developing a platform offering know-how in the

field of pharmacogenomics. It has received several prizes: Argos Spin(Argos

Program from USC), Model2Market Universia Prize(Spin2016) and Best Business

Idea (2016, Revista Emprendedores).

SADVIA. This project is focused in providing scientific advice to the companies in

order to be a bridge between them and the research university groups. It was

awarded with the prize “Santander YUZZ Woman 2016”

Patents: 2 new applications were presented from CiMUS groups and 3 of the previous

applications were registered. Also there was 4 international extension from

previous patent applications.

2. CONFERENCES AND SEMINARS

a. Seminars:

VI

49 seminars were hold at the CiMUS. There are four different categories in these

seminars:

Frontiers in Science: In this program the CiMUS invite an international researcher

who is a reference in the field to give a talk and meeting scientists at the centre.

This year was Prof. John Parrington from Oxford University. The title of his lecture was

The genome editing revolution – how will it transform medicine and agriculture and how do

we guard against potential perils?

CiMUS Update/Happy Fridays/Seminars: During the past year we continue

scheduling different kind of lectures/seminars. These include: a) the ones

presented by CIMUS´s PIs explaining to the rest of members of the Center their

current research (CIMUS Update); b) The formal presentation of the research carry

out by either predocs in their last year or early postdocs of their projects (Happy

Fridays); c) General seminars deliver by leading scientists. A total 30 of these were

scheduled in 2016.

Phd Programs Conferences: The PhD programs Endocrinology, Drug Research and

Development, Molecular Medicine and Nanofar organized 2 join Conferences

Cycles:

o Biomedicine: Beyond the laboratory: Hosted 5 conferences: "Cheating"

significa fraude": Integridad en investigacion científica; "El

desconocimiento de la ley no exime de su cumplimiento:" Legislación en

experimentación animal; "Inbiomotion: from bench to spin off"; "An

affair with the RANK pathway: novel applications of a known drug"; "El

desconocimiento de la ley no exime de su cumplimiento:" Legislación en

experimentación con humanos.

o Advanced experimental models and proteomics in nanomedicine and

molecular medicine: Hosted 4 conferences: Human cell and tissue

models for the prediction of in vivo drug disposition;Advanced animal

models of human diseases; Proteomics informed pharmacokinetic

models;Investigation of intestinal permeationenhancers: from in vitro to

in vivotitles

b. Other activities:

IV BioSpeedDating Day: Organized by Bioga at CiMUS on 26th of May 2016

VII

PINT OF SCIENCE: International event which was organized for its second edition in

Santiago de Compostela ( 18th-20th May 2016). Sulay Tovar was the chair of the

organization committee, and Miguel González Blanco and Anxo Vidal were also

members.

Regueifas da Ciencia: Under this scheme several scientific debates about polemic

topics were organized open to the general public. Miguel González Blanco, Sulay

Tovar and Anxo Vidal are part of the organization committee

3. DISCLOSURE AND COMMUNICATION

a. Web page and Social Media:

Web page: We are increasing the contents of CiMUS web page to mantain updated

it with the activities of the centre (http://www.usc.es/cimus/). 2016 was a year

with a high increase in the visits, reaching 139.329 visits.

Facebook profile, (https://www.facebook.com/CIMUS.USC) is the most visited

profile of the centre with 600 likes at the end of the year, almost the double than

the previous year.

Researchgate: The CiMUS profile continues to increase the number of CiMUS

researchers who join the active platform-profile. At the end of the year we have

more than 100 active profiles.

Twitter: Active since middle 2014, At the end of the 2016 we had 250 followers,

over twice the number in 2015 . https://twitter.com/cimususc

Linkedin: At the same time than twitter, we started to run the CiMUS Linkedin

profile, a network with a professional profile orientation. Regardless this specificity,

in 2016 we reach 207 followers. https://es.linkedin.com/company/cimus

Youtube chanel: This channel was created to be a multimedia tool to present the

groups of the centre via video. The channel got 1600 views, and 31 followers.

https://www.youtube.com/user/cimususc

b. CiMUS presentation to educative comunity: Students from high school, IES

Fontexeira(Muros), Colexío Abrente (Porto do Son), Colexio Calasanz (A Coruña) as well

as an institute with a more oriented technology profile, FESAN, visited the centre to

know the CiMUS labs and platforms.

http://www.usc.es/cimus/

https://twitter.com/cimususc

https://es.linkedin.com/company/cimus


VIII

Also group of teachers from different higg schools, which were in a program from the

DOMUS, have visited the CiMUS as part of this actualization program.

UniStem Day: international event focused in the stem cells and directed to the high

school students of all Europe.

c. CiMUS Presentation to the international community:

a. European Economic and Social Comittee: An delegation from European Economic

and Social Comittee visited us as a activity in the Meeting “Promover las empresas

innovadoras y de rápido crecimiento:El papel de las agrupaciones dedicadas a la

investigación intensiva”.

b. Center of Euro Regionals Studies (CEER): In the framework of meeting about

Geography, Innovation and Econimic growth organized by the CEER the attendants

visited the CiMUS

d. CiMUS as a hub in which different companies presented their new products

Seahorse and Agilent technologies 22nd of June of 2016

Scientific Report 2015

3

1. CENTER

a. GROUPS AND AREAS

The groups and areas are as follows:

CANCER

Anxo Vidal Figueroa Cell Cycle and Oncology http://www.usc.es/cimus/en/research/research-groups/cell-cycle-and-oncology-group-ciclon

Román Pérez Fernández Endocrine Oncology http://www.usc.es/cimus/en/research/research-groups/endocrine-oncology

José Antonio Costoya Puente Molecular Oncology (MOL) http://www.usc.es/cimus/en/research/research-groups/molecular-oncology-laboratory

Celia Mª Pombo Ramos Cell Signalling and Stress http://www.usc.es/cimus/en/research/research-groups/cellular-signalling-and-stress

Rosa Mª Señarís Rodríguez Neuroendocrinology http://www.usc.es/cimus/en/research/research-groups/neuroendocrinology-energy-homeostasis-metabolism-and-cancer

Carmen Rivas Vázquez Virus and Cancer http://www.usc.es/cimus/en/research/research-groups/virus-and-cancer

Miguel González Blanco DNA Repair and Genome Integrity Lab http://www.usc.es/cimus/en/research/research-groups/dna-repair-and-genome-integrity

ENDOCRINOLOGY AND NUTRITION

Carlos Diéguez González Functional Obesomic http://www.usc.es/cimus/en/research/research-groups/functional-obesomics

Miguel A. López Pérez NeurObesity http://www.usc.es/cimus/en/research/research-groups/neurobesity

José Joaquín Lado Abeal Thyroid and Metabolic Disease Unit (UETeM) http://www.usc.es/cimus/en/research/research-groups/thyroid-and-metabolic-diseases-unit

Mª Carmen García García Cytokines and Obesity http://www.usc.es/cimus/en/research/research-groups/cytokines-and-obesity

Clara Álvarez Villamarín Neoplasia and Endocrine Differentiation http://www.usc.es/cimus/en/research/research-groups/neoplasia-and-differentiation-endocrine-cells

Rubén Nogueiras Molecular Metabolism http://www.usc.es/cimus/en/research/research-groups/molecular-metabolism

NEUROSCIENCE

José Luis Labandeira García, Mª Josefa Guerra Seijas, Jannette Rodríguez Pallarés

Parkinson Disease http://www.usc.es/cimus/en/research/research-groups/cell-and-molecular-neurobiology-parkinsons-disease

Francisco González García Visual Science http://www.usc.es/cimus/en/research/research-groups/neuroscience-and-physiology-visual-system

Mª Ángeles Castro Pérez Molecular Pharmacology of G protein-coupled receptors http://www.usc.es/cimus/en/research/research-groups/molecular-pharmacology-g-protein-coupled-receptors

Jesús Rodríguez Requena Molecular Neuropathology http://www.usc.es/cimus/en/research/research-groups/brain-protein-malfunction

http://www.usc.es/cimus/en/research/research-groups/cell-cycle-and-oncology-group-ciclon

http://www.usc.es/cimus/en/research/research-groups/cell-cycle-and-oncology-group-ciclon

http://www.usc.es/cimus/en/research/research-groups/endocrine-oncology

http://www.usc.es/cimus/en/research/research-groups/molecular-oncology-laboratory

http://www.usc.es/cimus/en/research/research-groups/cellular-signalling-and-stress

http://www.usc.es/cimus/en/research/research-groups/neuroendocrinology-energy-homeostasis-metabolism-and-cancer

http://www.usc.es/cimus/en/research/research-groups/neuroendocrinology-energy-homeostasis-metabolism-and-cancer

http://www.usc.es/cimus/en/research/research-groups/virus-and-cancer

http://www.usc.es/cimus/en/research/research-groups/functional-obesomics

http://www.usc.es/cimus/en/research/research-groups/neurobesity

http://www.usc.es/cimus/en/research/research-groups/thyroid-and-metabolic-diseases-unit

http://www.usc.es/cimus/en/research/research-groups/thyroid-and-metabolic-diseases-unit

http://www.usc.es/cimus/en/research/research-groups/cytokines-and-obesity

http://www.usc.es/cimus/en/research/research-groups/neoplasia-and-differentiation-endocrine-cells

http://www.usc.es/cimus/en/research/research-groups/neoplasia-and-differentiation-endocrine-cells

http://www.usc.es/cimus/en/research/research-groups/molecular-metabolism

http://www.usc.es/cimus/en/research/research-groups/cell-and-molecular-neurobiology-parkinsons-disease

http://www.usc.es/cimus/en/research/research-groups/cell-and-molecular-neurobiology-parkinsons-disease

http://www.usc.es/cimus/en/research/research-groups/neuroscience-and-physiology-visual-system

http://www.usc.es/cimus/en/research/research-groups/neuroscience-and-physiology-visual-system

http://www.usc.es/cimus/en/research/research-groups/molecular-pharmacology-g-protein-coupled-receptors

http://www.usc.es/cimus/en/research/research-groups/molecular-pharmacology-g-protein-coupled-receptors

http://www.usc.es/cimus/en/research/research-groups/brain-protein-malfunction

4

CARDIOVASCULAR

J. R. González Juanatey Cardiovascular Area http://www.usc.es/cimus/en/research/research-groups/cardiovascular-area

Ángel García Alonso Platelet Proteomic http://www.usc.es/cimus/en/research/research-groups/platelet-proteomics

Juan Zalvide Torrente Vascular Biology http://www.usc.es/cimus/en/research/research-groups/laboratory-vascular-biology

Dolores Viña Cardiovascular Pharmacology http://www.usc.es/cimus/en/research/research-groups/pharmacology-chronic-diseases

DRUGS DEVELOPMENT

Mª Isabel Loza García Biofarma http://www.usc.es/cimus/en/research/research-groups/pharmacology-applied-drug-discovery

NANOMEDICINE AND NANOCARRIERS

M. José Alonso Fernández Nanobiopharmaceuticals http://www.usc.es/cimus/en/research/research-groups/nanobiofar-cimus-nanomedicine-and-drug-delivery

GENETICS AND FUNTIONAL GENOMICS

Ángel Carracedo Álvarez Genomic Medicine http://www.usc.es/cimus/en/research/research-groups/genomics-and-bioinformatics

Fernando Domínguez Puente Oncology Research http://www.usc.es/cimus/en/research/research-groups/galician-oncological-research-group

BIOSTATISTICS PLATFORM

Carmen Mª Cadarso Suárez Biostatistics http://www.usc.es/cimus/en/research/research-groups/biostatistics

b. New Talent

In 2016 the CiMUS has incorporated 1 researcher from competitive calls: Miguel

Fidalgo as Researcher Ramon y Cajal.

The Campus Vida Research Centers Network organized in 2016 for first time its

International Postdoctoral Programme. In this edition 3 postdoctoral positions were

offered, one for each center. The applicant selected by CiMUS was Diana Guallar

Artal.

The Biopharma group has a visiting professor, Juan Francisco López Giménez, from

the Institute of Biomedicine & Biotechnology of Cantabria.

Three postdoctioral researchers joined CiMUS with a Postdoc Contract from Xunta de

Galicia: Noelia Martínez Sánchez, Mónica Imbernon Piedra and Daniel Cacabelos

Barral.

http://www.usc.es/cimus/en/research/research-groups/cardiovascular-area

http://www.usc.es/cimus/en/research/research-groups/platelet-proteomics

http://www.usc.es/cimus/en/research/research-groups/laboratory-vascular-biology

http://www.usc.es/cimus/en/research/research-groups/pharmacology-chronic-diseases

http://www.usc.es/cimus/en/research/research-groups/pharmacology-applied-drug-discovery

http://www.usc.es/cimus/en/research/research-groups/pharmacology-applied-drug-discovery

http://www.usc.es/cimus/en/research/research-groups/nanobiofar-cimus-nanomedicine-and-drug-delivery

http://www.usc.es/cimus/en/research/research-groups/nanobiofar-cimus-nanomedicine-and-drug-delivery

http://www.usc.es/cimus/en/research/research-groups/genomics-and-bioinformatics

http://www.usc.es/cimus/en/research/research-groups/galician-oncological-research-group

http://www.usc.es/cimus/en/research/research-groups/galician-oncological-research-group

http://www.usc.es/cimus/en/research/research-groups/biostatistics

5

HRS4R

As part of the USC, the CiMUS participate in the HRS4R

strategy, a tool launched by the European Commission to

support universities, research institutions and organizations that

fund research in the application of The European Charter for

Researchers and The Code of Conduct for the Recruitment of Researchers, which aim

to contribute to the development of a European labor market attractive for researcher.

HR Award

The quality seal awarded by the European Commission "HR Excellence in Research”

identifies universities and institutions that generate and support the existence of a

stimulating and encouraging research environment.

c. NETWORKS/ALLIANCES

Diferent National and Regional networks are led by PIs from CiMUS :

Spanish Network of Drug discovery: Since 2015 the Biofarma group (PI

Mabel Loza) is leading this national network with funding by Ministerio

de Economía y Competitividad, Redes de Excelencia program. Other PIs

also integrated into this network are: Ángel Carracedo and Carlos

Diéguez

CIBEROBN: Carlos Diéguez (CiMUS Scientific Director and IP from

Funtional Obesomics group) is the Scientific Director of this network.

http://www.ciberobn.es/

BIOSTATNET (Biostatistics National Network): Carmen Cadarso

http://eio.usc.es/pub/biostatnet/

4 Groups from CiMUS are leading 4 autonomic networks:

REGID: Galizian Network of Rede Galega de Investigación e

Desenvolvemento de Medicamentos-IP coordinator: Mabel Loza

REDICENT: Network of stem cells and cell therapy. PI coordinator: Clara


http://eio.usc.es/pub/biostatnet/

6

V. Álvarez

RATGA: Galizian network of genetically modified animal. PI coordinator:

Jose Antonio Costoya

INBIOEST: New computacional tolos applied to research in health, sport

and the envioronment. PI coordinator: Carmen Cadarso

Also, the CiMUS’s groups are members of the following national and international

networks:

National:

CIBERs:

CIBEROBN: Carlos Diéguez, Miguel López; Rubén Nogueiras,

María García ans Sulay Tovar http://www.ciberobn.es/. Carlos

Diéguez (CiMUS Scientific Director and PI from Funtional

Obesomics group) is the Scientific Director of this network.

CIBERER: Ángel Carracedo http://www.ciberer.es/index.php

CIBERNED: Jose Luis Labandeira-García , MJ Guerra and

Jannette Rodriguezhttp://www.ciberned.es/

CIBERBBN: María José Alonso http://www.ciber-bbn.es/es

RETICs

TERCEL: José Luis Labandeira-García, Maria J. Guerra and Janette

Rodriguez: http://www.red-tercel.com/

RECAVA: Angel Carracedo and Jose Ramón González-Juanatey

http://www.recava.com/

REDINSCOR: Jose Ramón González-Juanatey

http://www.eulate.net/redinscor2/

COMBIOMED: MªIsabel Loza http://combiomed.isciii.es/

OFTARED: Francisco Gonzalez http://www.oftared.com/

Other networks:

Math‐in (Math-Industry Spanish Network): Carmen Cadarso

http://www.math-in.net/


http://www.ciberer.es/index.php

http://www.ciberned.es/

http://www.ciber-bbn.es/es

http://www.red-tercel.com/

http://www.recava.com/

http://www.eulate.net/redinscor2/

http://combiomed.isciii.es/

http://www.oftared.com/

http://www.math-in.net/

7

REMOA (Spanish Advanced Optical Microscopy Network):

Marian Castro

ADIPOPLAST (Red temática sobre plasticidad adiposa y sus

patologías): Miguel López and David Araujo

http://adipoplast.org/

International:

EUROFORGEN-NoE (European Forensic Genetics Network of

Excelellence): Angel Carracedo http://www.euroforgen.eu/

European Consortium of Lipodistrophies: David Araujo

http://www.european-lipodystrophies.org/

GLISTEN (GPCR-Ligand Interactions, Structures, and

Transmembrane Signalling: a European Research Network-

CMST COST Action CM1207): Marian Castro http://www.glisten-

gpcr.eu/

TRANSAUTOPHAGY: (European Network for Multidisciplinary

Research and Translation of Autophagy knowledge - COST

Action CA15138): Miguel López http://cost-transautophagy.eu/

http://adipoplast.org/

http://www.euroforgen.eu/

http://www.european-lipodystrophies.org/

http://www.glisten-gpcr.eu/

http://www.glisten-gpcr.eu/

http://cost-transautophagy.eu/

9

2. SCIENTIFIC OUTPUT

a. Papers

2013 2014 2015 2016

Number 201 149 183 163

IF 1104,623 815,603 939,923 847,488

Mean IF 5,496 5,474 5,136 5,231

Col- CiMUS 23 27 25 27

Col- Intern 67 72 66 73

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

2013 2014 2015 2016

% Publications per quartile

Q4

Q3

Q2

Q1 no D1

D1 0%

20%

40%

60%

80%

20132014

20152016


NoQ1

Q1

22,09%

47,85%

17,18%

8,59% 4,29%

Publications 2016

D1

Q1 no D1

Q2

Q3

Q4

69,94%

10

Publications (N):

0%

20%

40%

60%

80%

100%

120%

2013 2014 2015 2016


NoQ1

Q1

0%

20%

40%

60%

80%

100%

120%

2013 2014 2015 2016


NoQ1

Q1 no D1

D1

0

50

100

150

200

250

2013 2014 2015 2016

NoQ1

Q1

0

50

100

150

200

250

2013 2014 2015 2016

Publications per quartile

NoQ1

Q1 no D1

D1

0

50

100

150

20132014

20152016

Number Publications per quartile

NoQ1

Q1

11

IF Average

0

5

10

15

20132014

20152016

IF Average

NoQ1

Q1 no D1

D1

0

2

4

6

8

10

20132014

20152016

IF Average

NoQ1

Q1

13

Title Authors Journal Publication ISSN IF Q D

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.

Latorre-Pellicer A, Moreno-Loshuertos R, Lechuga-Vieco AV, Sánchez-Cabo F, Torroja C, Acín-Pérez R, Calvo E, Aix E, González-Guerra A, Logan A, Bernad-Miana ML, Romanos E, Cruz R, Cogliati S, Sobrino B, Carracedo Á, Pérez-Martos A, Fernández-Silva P, Ruíz-Cabello J, Murphy MP, Flores I, Vázquez J, Enríquez JA.

Nature. 2016 Jul 28;535(7613):561-5.

0028-0836

38,138

Q1 D1

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.

O'Donoghue ML, Glaser R, Cavender MA, Aylward PE, Bonaca MP, Budaj A, Davies RY, Dellborg M, Fox KA, Gutierrez JA, Hamm C, Kiss RG, Kovar F, Kuder JF, Im KA, Lepore JJ, Lopez-Sendon JL, Ophuis TO, Parkhomenko A, Shannon JB, Spinar J, Tanguay JF, Ruda M, Steg PG, Theroux P, Wiviott SD, Laws I, Sabatine MS, Morrow DA; LATITUDE-TIMI 60 Investigators..

JAMA. 2016 Apr 19;315(15):1591-9.

0098-7484

37,684

Q1 D1

Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.

Fidalgo M, Huang X, Guallar D, Sanchez-Priego C, Valdes VJ, Saunders A, Ding J, Wu WS, Clavel C, Wang J.

Cell Stem Cell.

2016 Sep 1;19(3):355-69.

1934-5909

22,387

Q1 D1

TCT-138 Multivessel versus culprit-only percutaneous coronary intervention in ST-segment elevation myocardial infarction: analysis of a 8 year-all-comers registry.

Cid Alvarez AB, Galvao Braga C, Redondo Dieguez A, Trillo R, Lopez Otero D, Ocaranza-Sanchez R, Alvarez Alvarez B, Docherty K, González-Juanatey JR.

J Am Coll Cardiol.

2016 Nov 1;68(18S):B56.

0735-1097

17,759

Q1 D1

TCT-149 Impact of Chronic Total Occlusion in a Non-Infarct-related Artery on clinical outcomes in patients undergoing Primary Percutanous Coronary Intervention: analysis of a 8 year-all-comers prospective registry.

Cid Alvarez AB, Redondo Dieguez A, Galvao Braga C, Trillo R, Lopez Otero D, Ocaranza-Sanchez R, Alvarez Alvarez B, Docherty K, González-Juanatey JR.

J Am Coll Cardiol.

2016 Nov 1;68(18S):B61.

0735-1097

17,759

Q1 D1

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials.

Aguirre TA, Teijeiro-Osorio D, Rosa M, Coulter IS, Alonso MJ, Brayden DJ.

Adv Drug Deliv Rev.

2016 Nov 15;106(Pt B):223-241.

0169-409X

15,606

Q1 D1

14


Oral delivery of peptides: opportunities and issues for translation.

Brayden DJ, Alonso MJ. Adv Drug Deliv Rev.

2016 Nov 15;106(Pt B):193-195.

0169-409X

15,606

Q1 D1

Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs.

Griffin BT, Guo J, Presas E, Donovan MD, Alonso MJ, O'Driscoll CM.

Adv Drug Deliv Rev.

2016 Nov 15;106(Pt B):367-380.

0169-409X

15,606

Q1 D1

Lipid-based nanocarriers for oral peptide delivery. Niu Z, Conejos-Sánchez I, Griffin BT, O'Driscoll CM, Alonso MJ.

Adv Drug Deliv Rev.

2016 Nov 15;106(Pt B):337-354.

0169-409X

15,606

Q1 D1

Hypothalamic AMPK: a canonical regulator of whole-body energy balance.

López M, Nogueiras R, Tena-Sempere M, Diéguez C. Nat Rev Endocrinol.

2016 Jul;12(7):421-32.

1759-5029

15,432

Q1 D1

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.

Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; Authors/Task Force Members..

Eur Heart J. 2016 Jul 14;37(27):2129-200.

0195-668X

15,064

Q1 D1

Quality markers in cardiology: measures of outcomes and clinical practice--a perspective of the Spanish Society of Cardiology and of Thoracic and Cardiovascular Surgery.

López-Sendón JL, González-Juanatey JR, Pinto F, Castillo JC, Badimón L, Dalmau R, Torrecilla EG, Mínguez JR, Maceira AM, Pascual-Figal D, Moya-Prats JL, Sionis A, Zamorano JL.

Eur Heart J. 2016 Jan 1;37(1):12-23.

0195-668X

15,064

Q1 D1

Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene.

Barreto-Luis A, Pino-Yanes M, Corrales A, Campo P, Callero A, Acosta-Herrera M, Cumplido J, Ma SF, Martinez-Tadeo J, Villar J, Garcia JG, Carrillo T, Carracedo Á, Blanca M, Flores C.

J Allergy Clin Immunol.

2016 Mar;137(3):964-6.

0091-6749

12,485

Q1 D1

Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress.

Imbernon M, Sanchez-Rebordelo E, Romero-Picó A, Kalló I, Chee MJ, Porteiro B, Al-Massadi O, Contreras C, Fernø J, Senra A, Gallego R, Folgueira C, Seoane LM, van Gestel M, Adan RA, Liposits Z, Dieguez C, López M, Nogueiras R.

Hepatology. 2016 Oct;64(4):1086-104.

0270-9139

11,711

Q1 D1

15


Lynch Syndrome prediction model validation study group.. Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer.

Kastrinos F, Ojha RP, Leenen C, Alvero C, Mercado RC, Balmaña J, Valenzuela I, Balaguer F, Green R, Lindor NM, Thibodeau SN, Newcomb P, Win AK, Jenkins M, Buchanan DD, Bertario L, Sala P, Hampel H, Syngal S, Steyerberg EW;

J Natl Cancer Inst.

2016; 108(2): djv308

0027-8874

11,370

Q1 D1

p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.

González-Terán B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernández-Cosido L, Mora A, Crainiciuc G, Sáiz ML, Bernardo E, Leiva-Vega L, Rodríguez E, Bondía V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G.

EMBO J. 2016 Mar 1;35(5):536-52.

0261-4189

9,643 Q1 D1

A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis.

Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J.

Dev Cell. 2016 Dec 19;39(6):740-755.

1534-5807

9,338 Q1 D1

Carborane-Based Design of a Potent Vitamin D Receptor Agonist

Rocio Otero, Samuel Seoane, Rita Sigüeiro, Anna Y. Belorusova, Miguel A. Maestro, Roman Pérez-Fernández, Natacha Rochel, Antonio Mouriño

Chemical Science

2016 Feb; 7:1033-1037;

2041-6539

9,144 Q1 D1

Glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets.

Tudurí E, López M, Diéguez C, Nadal A, Nogueiras R. Trends Endocrinol Metab.

2016 May;27(5):304-18.

1043-2760

8,964 Q1 D1

Menopause and Parkinson's disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration.

Labandeira-Garcia JL, Rodriguez-Perez AI, Valenzuela R, Costa-Besada MA, Guerra MJ.

Front Neuroendocrinol.

2016 Oct;43:44-59.

0091-3022

8,852 Q1 D1

Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways.

Folgueira C, Beiroa D, Callon A, Al-Massadi O, Barja-Fernandez S, Senra A, Fernø J, López M, Dieguez C, Casanueva FF, Rohner-Jeanrenaud F, Seoane LM, Nogueiras R.

Diabetes. 2016 Feb;65(2):421-32.

0012-1797

8,784 Q1 D1

Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation.

de la Cruz-Herrera CF, Baz-Martínez M, Lang V, El Motiam A, Barbazán J, Couceiro R, Abal M, Vidal A, Esteban M, Muñoz-Fontela C, Nieto A, Rodríguez MS, Collado M, Rivas C.

Oncogene. 2016 Jun 2;35(22):2873-80.

0950-9232

7,932 Q1 D1

16


A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.

Martins L, Seoane-Collazo P, Contreras C, González-García I, Martínez-Sánchez N, González F, Zalvide J, Gallego R, Diéguez C, Nogueiras R, Tena-Sempere M, López M.

Cell Rep. 2016 Aug 23;16(8):2231-42.

2211-1247

7,870 Q1 -

Docetaxel-loaded polyglutamic acid-PEG nanocapsules for the treatment of metastatic cancer.

Borrajo E, Abellan-Pose R, Soto A, Garcia-Fuentes M, Csaba N, Alonso MJ, Vidal A.

J Control Release.

2016 Sep 28;238:263-71.

0168-3659

7,441 Q1 D1

The interaction of protamine nanocapsules with the intestinal epithelium: A mechanistic approach.

Thwala LN, Beloqui A, Csaba NS, González-Touceda D, Tovar S, Dieguez C, Alonso MJ, Préat V.

J Control Release.

2016 Dec 10;243:109-120.

0168-3659

7,441 Q1 D1

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.

Vázquez-Fernández E, Vos MR, Afanasyev P, Cebey L, Sevillano AM, Vidal E, Rosa I, Renault L, Ramos A, Peters PJ, Fernández JJ, van Heel M, Young HS, Requena JR, Wille H.

PLoS Pathog.

2016 Sep 8;12(9):e1005835.

1553-7366

7,003 Q1 D1

17


Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M,

PLoS Pathog.

2016 Jul 28;12(7):e1005763.

1553-7366

7,003 Q1 D1

18


Hypothalamic Leptin Resistance: From BBB to BBSome.

López M. PLoS Genet. 2016 May 5;12(5):e1005980.

1553-7404

6,661 Q1 D1

High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides.

Gamba I, Salvadó I, Brissos RF, Gamez P, Brea J, Loza MI, Vázquez ME, Vázquez López M.

Chem Commun (Camb).

2016 Jan 21;52(6):1234-7.

1359-7345

6,567 Q1 -

Membrane-disrupting iridium(iii) oligocationic organometallopeptides.

Salvadó I, Gamba I, Montenegro J, Martínez-Costas J, Brea JM, Loza MI, Vázquez López M, Vázquez ME.

Chem Commun (Camb).

2016 Sep 21;52(73):11008-11.

1359-7345

6,567 Q1 -

Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by β-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue.

Victorio JA, Clerici SP, Palacios R, Alonso MJ, Vassallo DV, Jaffe IZ, Rossoni LV, Davel AP.

Hypertension.

2016 Sep;68(3):726-35.

0194-911X

6,350 Q1 D1

Comparison of international normalized ratio audit parameters in patients enrolled in GARFIELD-AF and treated with vitamin K antagonists.

Fitzmaurice DA, Accetta G, Haas S, Kayani G, Lucas Luciardi H, Misselwitz F, Pieper K, Ten Cate H, Turpie AG, Kakkar AK; GARFIELD-AF Investigators.

Br J Haematol.

2016 Aug;174(4):610-23.

0007-1048

5,812 Q1 -

Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia.

Costas J, Carrera N, Alonso P, Gurriarán X, Segalàs C, Real E, López-Solà C, Mas S, Gassó P, Domènech L, Morell M, Quintela I, Lázaro L, Menchón JM, Estivill X, Carracedo Á.

Transl Psychiatry.

2016 Mar 29;6:e768.

2158-3188

5,538 Q1 -

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline.

Brown RJ, Araujo-Vilar D, Cheung PT, Dunger D, Garg A, Jack M, Mungai L, Oral EA, Patni N, Rother KI, von Schnurbein J, Sorkina E, Stanley T, Vigouroux C, Wabitsch M, Williams R, Yorifuji T.

J Clin Endocrinol Metab.

2016 Dec;101(12):4500-4511.

0021-972X

5,531 Q1 -

Aging-related Increase in Rho Kinase Activity in the Nigral Region Is Counteracted by Physical Exercise.

Muñoz A, Corrêa CL, Villar-Cheda B, Costa-Besada MA, Labandeira-Garcia JL.

J Gerontol A Biol Sci Med Sci.

2016 Oct;71(10):1254-7.

1079-5006

5,476 Q1 D1

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.

Franco R, Casadó-Anguera V, Muñoz A, Petrovic M, Navarro G, Moreno E, Lanciego JL, Labandeira-García JL, Cortés A, Casadó V.

Mol Neurobiol.

2016 Oct;53(8):5436-45.

0893-7648

5,397 Q1 -

19


Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration.

Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL.

Cell Death Dis.

2016 Oct 20;7(10):e2427.

2041-4889

5,378 Q1 -

Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty.

Manfredi-Lozano M, Roa J, Ruiz-Pino F, Piet R, Garcia-Galiano D, Pineda R, Zamora A, Leon S, Sanchez-Garrido MA, Romero-Ruiz A, Dieguez C, Vazquez MJ, Herbison AE, Pinilla L, Tena-Sempere M.

Mol Metab. 2016 Aug 11;5(10):844-57.

2212-8778

5,363 Q1 -

Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance.

Alvarez-Crespo M, Csikasz RI, Martínez-Sánchez N, Diéguez C, Cannon B, Nedergaard J, López M.

Mol Metab. 2016 Feb 10;5(4):271-82.

2212-8778

5,363 Q1 -

Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes): a fish adapted to demersal life.

Figueras A, Robledo D, Corvelo A, Hermida M, Pereiro P, Rubiolo JA, Gómez-Garrido J, Carreté L, Bello X, Gut M, Gut IG, Marcet-Houben M, Forn-Cuní G, Galán B, García JL, Abal-Fabeiro JL, Pardo BG, Taboada X, Fernández C, Vlasova A, Hermoso-Pulido A, Guigó R, Álvarez-Dios JA, Gómez-Tato A, Viñas A, Maside X, Gabaldón T, Novoa B, Bouza C, Alioto T, Martínez P.

DNA Res. 2016 Jun;23(3):181-92.

1340-2838

5,267 Q1 -

Sequence variation between 462 human individuals fine-tunes functional sites of RNA processing.

Ferreira PG, Oti M, Barann M, Wieland T, Ezquina S, Friedländer MR, Rivas MA, Esteve-Codina A; GEUVADIS Consortium., Rosenstiel P, Strom TM, Lappalainen T, Guigó R, Sammeth M

Sci Rep. 2016 Sep 12;6:32406.

2045-2322

5,228 Q1 -

Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.

Martinón-Torres F, Png E, Khor CC, Davila S, Wright VJ, Sim KS, Vega A, Fachal L, Inwald D, Nadel S, Carrol ED, Martinón-Torres N, Alonso SM, Carracedo A, Morteruel E, López-Bayón J, Torre AC, Monge CC, de Aguilar PA, Torné EE, Martínez-Padilla MD, Martinón-Sánchez JM, Levin M, Hibberd ML, Salas A; ESIGEM network.; ESPID meningococcal consortium – UK.; EUCLIDS consortium members -Imperial College London (www.euclids-project.eu).

Sci Rep. 2016 Nov 2;6:35842.

2045-2322

5,228 Q1 -

20


Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches.

Vélez P, Ocaranza-Sánchez R, López-Otero D, Grigorian-Shamagian L, Rosa I, Guitián E, García-Acuña JM, González-Juanatey JR, García Á.

Sci Rep. 2016 Dec 22;6:39603.

2045-2322

5,228 Q1 -

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia.

Poveda NE, Garcés MF, Ruiz-Linares CE, Varón D, Valderrama S, Sanchez E, Castiblanco-Cortes A, Agudelo-Zapata Y, Sandoval-Alzate HF, Leal LG, Ángel-Müller E, Ruíz-Parra AI, González-Clavijo AM, Diéguez C, Nogueiras R, Caminos JE.

Sci Rep. 2016 Feb 1;6:20073.

2045-2322

5,228 Q1 -

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test.

Sandoval-Alzate HF, Agudelo-Zapata Y, González-Clavijo AM, Poveda NE, Espinel-Pachón CF, Escamilla-Castro JA, Márquez-Julio HL, Alvarado-Quintero H, Rojas-Rodríguez FG, Arteaga-Díaz JM, Eslava-Schmalbach JH, Garcés-Gutiérrez MF, Vrontakis M, Castaño JP, Luque RM, Diéguez C, Nogueiras R, Caminos JE.

Sci Rep. 2016 Aug 23;6:31661.

2045-2322

5,228 Q1 -

Cell senescence is an antiviral defense mechanism. Baz-Martínez M, Da Silva-Álvarez S, Rodríguez E, Guerra J, El Motiam A, Vidal A, García-Caballero T, González-Barcia M, Sánchez L, Muñoz-Fontela C, Collado M, Rivas C.

Sci Rep. 2016 Nov 16;6:37007.

2045-2322

5,228 Q1 -

Regulation of Ebola virus VP40 matrix protein by SUMO.

Baz-Martínez M, El Motiam A, Ruibal P, Condezo GN, de la Cruz-Herrera CF, Lang V, Collado M, San Martín C, Rodríguez MS, Muñoz-Fontela C, Rivas C.

Sci Rep. 2016 Nov 16;6:37258.

2045-2322

5,228 Q1 -

Computational Drug Target Screening through Protein Interaction Profiles.

Vilar S, Quezada E, Uriarte E, Costanzi S, Borges F, Viña D, Hripcsak G.

Sci Rep. 2016 Nov 15;6:36969.

2045-2322

5,228 Q1 -

Human Ischemic Cardiomyopathy Shows Cardiac Nos1 Translocation and its Increased Levels are Related to Left Ventricular Performance.

Roselló-Lletí E, Carnicer R, Tarazón E, Ortega A, Gil-Cayuela C, Lago F, González-Juanatey JR, Portolés M, Rivera M.

Sci Rep. 2016 Apr 4;6:24060.

2045-2322

5,228 Q1 -

Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts.

Roselló-Lletí E, Tarazón E, Ortega A, Gil-Cayuela C, Carnicer R, Lago F, González-Juanatey JR, Portolés M, Rivera M.

Sci Rep. 2016 Aug 2;6:30902.

2045-2322

5,228 Q1 -

21


Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins.

Bouzo-Lorenzo M, Santo-Zas I, Lodeiro M, Nogueiras R, Casanueva FF, Castro M, Pazos Y, Tobin AB, Butcher AJ, Camiña JP.

Sci Rep. 2016 Mar 3;6:22495.

2045-2322

5,228 Q1 -

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.

Luque RM, Cordoba-Chacon J, Pozo-Salas AI, Porteiro B, de Lecea L, Nogueiras R, Gahete MD, Castaño JP.

Sci Rep. 2016 Nov 30;6:37992.

2045-2322

5,228 Q1 -

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.

Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; Authors/Task Force Members.; Document Reviewers..

Eur J Heart Fail.

2016 Aug;18(8):891-975.

1388-9842

5,135 Q1 -

Estradiol and brown fat. López M, Tena-Sempere M. Best Pract Res Clin Endocrinol Metab.

2016 Aug;30(4):527-536.

1521-690X

5,070 Q1 -

Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells.

Aguado A, Fischer T, Rodríguez C, Manea A, Martínez-González J, Touyz RM, Hernanz R, Alonso MJ, Dixon DA, Briones AM, Salaices M.

J Hypertens. 2016 Feb;34(2):253-65.

0263-6352

5,062 Q1 -

Molecular mechanisms of appetite and obesity: a role for brain AMPK.

Martínez de Morentin PB, Urisarri A, Couce ML, López M.

Clin Sci (Lond).

2016 Oct 1;130(19):1697-709.

0143-5221

5,016 Q1 -

Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging.

Rodriguez-Perez AI, Borrajo A, Diaz-Ruiz C, Garrido-Gil P, Labandeira-Garcia JL.

Oncotarget. 2016 May 24;7(21):30049-67.

1949-2553

5,008 Q1 -

Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system.

Freire-Aradas A, Phillips C, Mosquera-Miguel A, Girón-Santamaría L, Gómez-Tato A, Casares de Cal M, Álvarez-Dios J, Ansede-Bermejo J, Torres-Español M, Schneider PM, Pośpiech E, Branicki W, Carracedo Á, Lareu MV.

Forensic Sci Int Genet.

2016 Sep;24:65-74.

1872-4973

4,988 Q1 D1

22


Inter-laboratory evaluation of the EUROFORGEN Global ancestry-informative SNP panel by massively parallel sequencing using the Ion PGM™.

Eduardoff M, Gross TE, Santos C, de la Puente M, Ballard D, Strobl C, Børsting C, Morling N, Fusco L, Hussing C, Egyed B, Souto L, Uacyisrael J, Syndercombe Court D, Carracedo Á, Lareu MV, Schneider PM, Parson W, Phillips C; EUROFORGEN-NoE Consortium., Parson W, Phillips C.


2016 Jul;23:178-89.

1872-4973

4,988 Q1 D1

Pacifiplex: an ancestry-informative SNP panel centred on Australia and the Pacific region.

Santos C, Phillips C, Fondevila M, Daniel R, van Oorschot RA, Burchard EG, Schanfield MS, Souto L, Uacyisrael J, Via M, Carracedo Á, Lareu MV.


2016 Jan;20:71-80.

1872-4973

4,988 Q1 D1

The Global AIMs Nano set: A 31-plex SNaPshot assay of ancestry-informative SNPs.

de la Puente M, Santos C, Fondevila M, Manzo L; EUROFORGEN-NoE Consortium., Carracedo Á, Lareu MV, Phillips C.


2016 May;22:81-8.

1872-4973

4,988 Q1 D1

Acute stimulation of brain mu opioid receptors inhibits glucose-stimulated insulin secretion via sympathetic innervation.

Tudurí E, Beiroa D, Stegbauer J, Fernø J, López M, Diéguez C, Nogueiras R.

Neuropharmacology.

2016 Nov;110(Pt A):322-32.

0028-3908

4,936 Q1 D1

A novel mechanism of neuroprotection: Blood glutamate grabber.

Castillo J, Loza MI, Mirelman D, Brea J, Blanco M, Sobrino T, Campos F.

J Cereb Blood Flow Metab.

2016 Feb;36(2):292-301.

0271-678X

4,929 Q1 -

Targeting cancer with hyaluronic acid-based nanocarriers: recent advances and translational perspectives.

Cadete A, Alonso MJ. Nanomedicine (Lond).

2016 Sep;11(17):2341-57.

1743-5889

4,889 Q1 -

Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC).

Xicola RM, Bontu S, Doyle BJ, Rawson J, Garre P, Lee E, de la Hoya M, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellví-Bel S, Alenda C, Jover R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Newcomb PA, Lindor N, Potter JD, Baron JA, Ellis NA, Caldes T, LLor X.

Carcinogenesis.

2016 Aug;37(8):751-8.

0143-3334

4,874 Q1 -

Metformin: A Hopeful Promise in Aging Research. Novelle MG, Ali A, Diéguez C, Bernier M, de Cabo R. Cold Spring Harb Perspect Med.

2016 Mar 1;6(3):a025932.

2157-1422

4,866 Q1 -

23


Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.

García-Rúa V, Feijóo-Bandín S, Rodríguez-Penas D, Mosquera-Leal A, Abu-Assi E, Beiras A, María Seoane L, Lear P, Parrington J, Portolés M, Roselló-Lletí E, Rivera M, Gualillo O, Parra V, Hill JA, Rothermel B, González-Juanatey JR, Lago F.

J Physiol. 2016 Jun 1;594(11):3061-77.

0022-3751

4,731 Q1 D1

Assessment of effectiveness and security in high pressure postdilatation of bioresorbable vascular scaffolds during percutaneous coronary intervention. Study in a contemporary, non-selected cohort of Spanish patients.

Abellas-Sequeiros RA, Ocaranza-Sanchez R, Galvão Braga C, Raposeiras-Roubin S, Lopez-Otero D, Cid-Alvarez B, Souto-Castro P, Trillo-Nouche R, Gonzalez-Juanatey JR.

Int J Cardiol. 2016 Sep 15;219:264-70.

0167-5273

4,638 Q1 -

Impact of blood transfusion on in-hospital myocardial infarctions according to patterns of acute coronary syndrome: Insights from the BleeMACS registry.

Gili S, D'Ascenzo F, Lococo MF, Moretti C, Gaita F, Raposeiras-Roubín S, Abu-Assi E, Henriques JP, Saucedo J, González-Juanatey JR, Wilton SB, Kikkert WJ, Nuñez-Gil I, Ariza-Sole A, Song X, Alexopoulos D, Liebetrau C, Kawaji T, Huczek Z, Nie SP, Fujii T, Correia L, Kawashiri MA, García-Acuña JM, Southern D, Alfonso E, Terol B, Garay A, Zhang D, Chen Y, Xanthopoulou I, Osman N, Möllmann H, Shiomi H, Scarano S, Kowara M, Filipiak K, Wang X, Yan Y, Fan JY, Ikari Y, Nakahashi T, Sakata K, Yamagishi M, Kalpak O, Kedev S.

Int J Cardiol. 2016 Oct 15;221:364-70.

0167-5273

4,638 Q1 -

Participation and adherence to cardiac rehabilitation programs. A systematic review.

Ruano-Ravina A, Pena-Gil C, Abu-Assi E, Raposeiras S, van 't Hof A, Meindersma E, Bossano Prescott EI, González-Juanatey JR.

Int J Cardiol. 2016 Nov 15;223:436-443.

0167-5273

4,638 Q1 -

Risk of pacemaker implantation after uneventful successful cavotricuspid isthmus radiofrequency ablation in patients with common atrial flutter.

Rodríguez-Mañero M, González-Melchor L, Ballesteros G, Raposeiras-Roubín S, García-Seara J, López XA, Cambeiro CG, Alcalde O, García-Bolao I, Martínez-Sande L, González-Juanatey JR.

Int J Cardiol. 2016 Jan 1;202:285-8.

0167-5273

4,638 Q1 -

24


Safety and effectiveness of the new P2Y12r inhibitor agents vs clopidogrel in ACS patients according to the geographic area: East Asia vs Europe.

Giordana F, Montefusco A, D'Ascenzo F, Moretti C, Scarano S, Abu-Assi E, Raposeiras-Roubín S, Henriques JP, Saucedo J, González-Juanatey JR, Wilton SB, Kikkert WJ, Nuñez-Gil I, Ariza-Sole A, Song X, Alexopoulos D, Liebetrau C, Kawaji T, Huczek Z, Nie SP, Fujii T, Correia L, Kawashiri MA, García-Acuña JM, Southern D, Alfonso E, Terol B, Garay A, Zhang D, Chen Y, Xanthopoulou I, Osman N, Möllmann H, Shiomi H, Kowara M, Filipiak K, Wang X, Yan Y, Fan JY, Ikari Y, Nakahayshi T, Sakata K, Yamagishi M, Kalpak O, Kedev S, Gaita F.

Int J Cardiol. 2016 Oct 1;220:488-95.

0167-5273

4,638 Q1 -

Natriuretic Peptides: Consensus Call for Use. Pascual Figal DA, Casademont J, Lobos JM, Piñera P, Bayes-Genis A, Ordóñez Llanos J, González-Juanatey JR.

Rev Esp Cardiol (Engl Ed).

2016 Sep;69(9):817-9.

0300-8932

4,596 Q1 -

2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure.

Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P.


2016 Dec;69(12):1167.

0300-8932

4,596 Q1 -

A Step Ahead in Secondary Prevention of Cardiovascular Risk. Consensus Document on Clinical Use of the Polypill.

González-Juanatey JR, Mostaza JM, Lobos JM, Abarca B, Llisterri JL.


2016 Jun;69(6):547-50.

0300-8932

4,596 Q1 -

Challenges in Oral Lipid-lowering Therapy: Position Document of the Spanish Society of Cardiology.

Anguita Sánchez M, Castro Conde A, Cordero Fort A, García-Moll Marimón X, Gómez Doblas JJ, González-Juanatey JR, Lidón Corbi RM, López-Sendón JL, Mostaza Prieto J, Rodríguez Padial L.


2016 Nov;69(11):1083-1087.

0300-8932

4,596 Q1 -

Comparison Between 3 Bleeding Scoring Systems in Nonvalvular Atrial Fibrillation Patients. What Can the New ORBIT Score Provide?

Abumuaileq RR, Abu-Assi E, Raposeiras-Roubin S, Rodríguez-Mañero M, Peña-Gil C, González-Juanatey JR.


2016 Nov;69(11):1112-1114.

0300-8932

4,596 Q1 -

25


Coronary Artery Dominance and Long-term Prognosis in Patients With ST-segment Elevation Myocardial Infarction Treated With Primary Angioplasty.

Abu-Assi E, Castiñeira-Busto M, González-Salvado V, Raposeiras-Roubin S, Riziq-Yousef Abumuaileq R, Peña-Gil C, Rigueiro-Veloso P, Ocaranza R, García-Acuña JM, González-Juanatey JR.


2016 Jan;69(1):19-27.

0300-8932

4,596 Q1 -

Degree of Lipid Control in Patients With Coronary Heart Disease and Measures Adopted by Physicians. REPAR Study.

Galve E, Cordero A, Cequier A, Ruiz E, González-Juanatey JR.


2016 Oct;69(10):931-938.

0300-8932

4,596 Q1 -

Excimer Laser Coronary Atherectomy During Percutaneous Coronary Intervention.

Ocaranza-Sánchez R, Abellás-Sequeiros RA, Galvão-Braga C, Trillo-Nouche R, González-Juanatey JR.


2016 Sep;69(9):867-8.

0300-8932

4,596 Q1 -

On the Way to a Better Use of Anticoagulants in Nonvalvular Atrial Fibrillation. Proposed Amendment to the Therapeutic Positioning Report UT/V4/23122013.

Roldán I, Marín F; Cardiovascular Thrombosis Group of the Spanish Society of Cardiology and the proposal development Committee.; Spanish Society of Cardiology (SEC).; Spanish Thrombosis and Hemostasis Society (SETH).; Spanish Society of Neurology (SEN).; Spanish Society of Emergency Medicine (SEMES).; Spanish Society of Internal Medicine (SEMI).; Spanish Society of Primary Care Physicians (SEMERGEN)..


2016 Jun;69(6):551-3.

0300-8932

4,596 Q1 -

Prognostic Effect of Body Mass Index in Patients With an Implantable Cardioverter-defibrillator for Primary Prevention of Sudden Death.

González-Cambeiro MC, Rodríguez-Mañero M, Abellas-Sequeiros A, Moreno-Arribas J, Filgueira-Rama D, González-Juanatey JR.


2016 Oct;69(10):990-992.

0300-8932

4,596 Q1 -

The Healthcare of Patients With Acute and Critical Heart Disease. Position of the Spanish Society of Cardiology.

Worner F, San Román A, Sánchez PL, Viana Tejedor A, González-Juanatey JR.


2016 Mar;69(3):239-42.

0300-8932

4,596 Q1 -

The Risk of Cardiovascular Events After an Acute Coronary Event Remains High, Especially During the First Year, Despite Revascularization.

Abu-Assi E, López-López A, González-Salvado V, Redondo-Diéguez A, Peña-Gil C, Bouzas-Cruz N, Raposeiras-Roubín S, Riziq-Yousef Abumuaileq R, García-Acuña JM, González-Juanatey JR.


2016 Jan;69(1):11-8.

0300-8932

4,596 Q1 -

26


Trends in Risk Factors and Treatments in Patients With Stable Ischemic Heart Disease Seen at Cardiology Clinics Between 2006 and 2014.

Cordero A, Galve E, Bertomeu-Martínez V, Bueno H, Fácila L, Alegría E, Cequier Á, Ruiz E, González-Juanatey JR.


2016 Apr;69(4):401-7.

0300-8932

4,596 Q1 -

The relationship between surname frequency and Y chromosome variation in Spain.

Martinez-Cadenas C, Blanco-Verea A, Hernando B, Busby GB, Brion M, Carracedo A, Salas A, Capelli C.

Eur J Hum Genet.

2016 Jan;24(1):120-8.

1018-4813

4,580 Q1 -

Clinical Utility Gene Card for: Congenital Generalized Lipodystrophy.

Jéru I, Vatier C, Araujo-Vilar D, Vigouroux C, Lascols O. Eur J Hum Genet.

2016 Nov;24(11).

1018-4813

4,580 Q1 -

Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators.

Decara J, Arrabal S, Beiroa D, Rivera P, Vargas A, Serrano A, Pavón FJ, Ballesteros J, Dieguez C, Nogueiras R, Rodríguez de Fonseca F, Suárez J.

Biofactors. 2016 Nov 12;42(6):600-611.

0951-6433

4,504 Q1 -

Targeted resequencing of regulatory regions at schizophrenia risk loci: Role of rare functional variants at chromatin repressive states.

González-Peñas J, Amigo J, Santomé L, Sobrino B, Brenlla J, Agra S, Paz E, Páramo M, Carracedo Á, Arrojo M, Costas J.

Schizophr Res.

2016 Jul;174(1-3):10-6. D

0920-9964

4,453 Q1 -

Monomorphic ventricular tachycardia in patients with Brugada syndrome: A multicenter retrospective study.

Rodríguez-Mañero M, Sacher F, de Asmundis C, Maury P, Lambiase PD, Sarkozy A, Probst V, Gandjbakhch E, Castro-Hevia J, Saenen J, Fukushima Kusano K, Rollin A, Arbelo E, Valderrábano M, Arias MA, Mosquera-Pérez I, Schilling R, Chierchia GB, García-Bolao I, García-Seara J, Hernandez-Ojeda J, Kamakura T, Martínez-Sande L, González-Juanatey JR, Haïssaguerre M, Brugada J, Brugada P.

Heart Rhythm.

2016 Mar;13(3):669-82.

1547-5271

4,391 Q1 -

Effects of Rho Kinase Inhibitors on Grafts of Dopaminergic Cell Precursors in a Rat Model of Parkinson's Disease.

Rodriguez-Pallares J, Rodriguez-Perez AI, Muñoz A, Parga JA, Toledo-Aral JJ, Labandeira-Garcia JL.

Stem Cells Transl Med.

2016 Jun;5(6):804-15.

2157-6564

4,247 Q1 -

Selective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node.

Alonso-Nocelo M, Abellan-Pose R, Vidal A, Abal M, Csaba N, Alonso MJ, Lopez-Lopez R, de la Fuente M.

J Nanobiotechnology.

2016 Jun 23;14(1):51.

1477-3155

4,239 Q1 -

27


Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.

Al-Massadi O, Porteiro B, Kuhlow D, Köhler M, Gonzalez-Rellan MJ, Garcia-Lavandeira M, Díaz-Rodríguez E, Quiñones M, Senra A, Alvarez CV, López M, Diéguez C, Schulz TJ, Nogueiras R.

Endocrinology.

2016 Jul;157(7):2735-49.

0013-7227

4,159 Q1 -

EndoG Knockout Mice Show Increased Brown Adipocyte Recruitment in White Adipose Tissue and Improved Glucose Homeostasis.

Pardo R, Blasco N, Vilà M, Beiroa D, Nogueiras R, Cañas X, Simó R, Sanchis D, Villena JA.

Endocrinology.

2016 Oct;157(10):3873-3887.

0013-7227

4,159 Q1 -

Glucose and Inflammatory Cells Decrease Adiponectin in Epicardial Adipose Tissue Cells: Paracrine Consequences on Vascular Endothelium.

Fernández-Trasancos Á, Guerola-Segura R, Paradela-Dobarro B, Álvarez E, García-Acuña JM, Fernández ÁL, González-Juanatey JR, Eiras S.

J Cell Physiol.

2016 May;231(5):1015-23.

0021-9541

4,155 Q1 -

Polyaminoacid nanocapsules for drug delivery to the lymphatic system: Effect of the particle size.

Abellan-Pose R, Teijeiro-Valiño C, Santander-Ortega MJ, Borrajo E, Vidal A, Garcia-Fuentes M, Csaba N, Alonso MJ.

Int J Pharm. 2016 Jul 25;509(1-2):107-17.

0378-5173

3,994 Q1 -

Biological evaluation of new vitamin D(2) analogues. Corcoran A, Bermudez MA, Seoane S, Perez-Fernandez R, Krupa M, Pietraszek A, Chodyński M, Kutner A, Brown G, Marcinkowska E.

J Steroid Biochem Mol Biol.

2016 Nov;164:66-71.

0960-0760

3,985 Q1 -

Altered functional connectivity of the default mode network in Williams syndrome: a multimodal approach.

Sampaio A, Moreira PS, Osório A, Magalhães R, Vasconcelos C, Férnandez M, Carracedo A, Alegria J, Gonçalves ÓF, Soares JM.

Dev Sci. 2016 Jul;19(4):686-95.

1363-755X

3,982 Q1 D1

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.

Estrada M, Herrera-Arozamena C, Pérez C, Viña D, Romero A, Morales-García JA, Pérez-Castillo A, Rodríguez-Franco MI.

Eur J Med Chem.

2016 Oct 4;121:376-86.

0223-5234

3,902 Q1 -

Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.

Kucwaj-Brysz K, Warszycki D, Podlewska S, Witek J, Witek K, González Izquierdo A, Satała G, Loza MI, Lubelska A, Latacz G, Bojarski AJ, Castro M, Kieć-Kononowicz K, Handzlik J.

Eur J Med Chem.

2016 Apr 13;112:258-69.

0223-5234

3,902 Q1 -

28


A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease.

Beloqui A, Memvanga PB, Coco R, Reimondez-Troitiño S, Alhouayek M, Muccioli GG, Alonso MJ, Csaba N, de la Fuente M, Préat V.

Colloids Surf B Biointerfaces.

2016 Jul 1;143:327-35.

0927-7765

3,902 Q1 -

Proteomic identification of putative biomarkers for early detection of sudden cardiac death in a family with a LMNA gene mutation causing dilated cardiomyopathy.

Izquierdo I, Rosa I, Bravo SB, Guitián E, Pérez-Serra A, Campuzano O, Brugada R, Mangas A, García Á, Toro R.

J Proteomics.

2016 Oct 4;148:75-84.

1874-3919

3,867 Q1 -

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT.

Contreras C, Nogueiras R, Diéguez C, Medina-Gómez G, López M.

Mol Cell Endocrinol.

2016 Dec 15;438:107-115.

0303-7207

3,859 Q2 -

Chronic and progressive Parkinson's disease MPTP model in adult and aged mice.

Muñoz-Manchado AB, Villadiego J, Romo-Madero S, Suárez-Luna N, Bermejo-Navas A, Rodríguez-Gómez JA, Garrido-Gil P, Labandeira-García JL, Echevarría M, López-Barneo J, Toledo-Aral JJ.

J Neurochem.

2016 Jan;136(2):373-87.

0022-3042

3,842 Q2 -

Physical Properties and Stability of Soft Gelled Chitosan-Based Nanoparticles.

Goycoolea FM, Brunel F, Gueddari NE, Coggiola A, Lollo G, Moerschbacher BM, Remuñán-López C, Delair T, Domard A, Alonso MJ.

Macromol Biosci.

2016 Dec;16(12):1873-1882.

1616-5187

3,680 Q2 -

Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance.

Lage R, Fernø J, Nogueiras R, Diéguez C, López M. Biochem J. 2016 Nov 15;473(22):4063-4082. Review.

0264-6021

3,562 Q2 -

Concise asymmetric syntheses of novel phenanthroquinolizidines.

Anton-Torrecillas C, Loza MI, Brea J, Gonzalez-Gomez JC.

Org Biomol Chem.

2016 Feb 21;14(7):2264-71.

1477-0520

3,559 Q1 -

In vitro, molecular modeling and behavioral studies of 3-{[4-(5-methoxy-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]methyl}-1,2-dihydroquinolin-2-one (D2AAK1) as a potential antipsychotic.

Kaczor AA, Targowska-Duda KM, Budzyńska B, Biała G, Silva AG, Castro M.

Neurochem Int.

2016 Jun;96:84-99.

0197-0186

3,385 Q2 -

29


A EUropean study on effectiveness and sustainability of current Cardiac Rehabilitation programmes in the Elderly: Design of the EU-CaRE randomised controlled trial.

Prescott E, Meindersma EP, van der Velde AE, Gonzalez-Juanatey JR, Iliou MC, Ardissino D, Zoccai GB, Zeymer U, Prins LF, Van't Hof AW, Wilhelm M, de Kluiver EP.

Eur J Prev Cardiol.

2016 Oct;23(2 suppl):27-40.

2047-4873

3,361 Q2 -

Synthesis, biological evaluation and molecular modeling o f phthalazin-1(2H)-one derivatives as novel cholinesterase inhibitors.

Vila N, Besada P, Viña D, Moro S, Terán C RSC Advances

2016 April 26; 6, 46170-46185

2046-2069

3,289 Q2 -

24 h nesfatin-1 treatment promotes apoptosis in cardiomyocytes.

Feijóo-Bandín S, Rodríguez-Penas D, García-Rúa V, Mosquera-Leal A, Abu-Assi E, Portolés M, Roselló-Lletí E, Rivera M, Diéguez C, González-Juanatey JR, Lago F.

Endocrine. 2016 Mar;51(3):551-5.

1355-008X

3,279 Q2 -

Type 1 familial partial lipodystrophy: understanding the Köbberling syndrome.

Guillín-Amarelle C, Sánchez-Iglesias S, Castro-Pais A, Rodriguez-Cañete L, Ordóñez-Mayán L, Pazos M, González-Méndez B, Rodríguez-García S, Casanueva FF, Fernández-Marmiesse A, Araújo-Vilar D.

Endocrine. 2016 Nov;54(2):411-421. PubMed PMID: 27473102.

1355-008X

3,279 Q2 -

Nesfatin-1: a new energy-regulating peptide with pleiotropic functions. Implications at cardiovascular level.

Feijóo-Bandín S, Rodríguez-Penas D, García-Rúa V, Mosquera-Leal A, González-Juanatey JR, Lago F.

Endocrine. 2016 Apr;52(1):11-29.

1355-008X

3,279 Q2 -

Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner.

Folgueira C, Sanchez-Rebordelo E, Barja-Fernandez S, Leis R, Tovar S, Casanueva FF, Dieguez C, Nogueiras R, Seoane LM.

Eur J Nutr. 2016 Mar;55(2):529-36.

1436-6207

3,239 Q2 -

30


A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics.

Mizzi C, Dalabira E, Kumuthini J, Dzimiri N, Balogh I, Başak N, Böhm R, Borg J, Borgiani P, Bozina N, Bruckmueller H, Burzynska B, Carracedo A, Cascorbi I, Deltas C, Dolzan V, Fenech A, Grech G, Kasiulevicius V, Kádaši Ľ, Kučinskas V, Khusnutdinova E, Loukas YL, Macek M Jr, Makukh H, Mathijssen R, Mitropoulos K, Mitropoulou C, Novelli G, Papantoni I, Pavlovic S, Saglio G, Setric J, Stojiljkovic M, Stubbs AP, Squassina A, Torres M, Turnovec M, van Schaik RH, Voskarides K, Wakil SM, Werk A, Del Zompo M, Zukic B, Katsila T, Lee MT, Motsinger-Rief A, Mc Leod HL, van der Spek PJ, Patrinos GP.

PLoS One. 2016 Sep 16;11(9):e0162866.

1932-6203

3,057 Q1 -

Skipped BSCL2 Transcript in Celia's Encephalopathy (PELD): New Insights on Fatty Acids Involvement, Senescence and Adipogenesis.

Sánchez-Iglesias S, Unruh-Pinheiro A, Guillín-Amarelle C, González-Méndez B, Ruiz-Riquelme A, Rodríguez-Cañete BL, Rodríguez-García S, Guillén-Navarro E, Domingo-Jiménez R, Araújo-Vilar D.

PLoS One. 2016 Jul 8;11(7):e0158874.

1932-6203

3,057 Q1 -

New Altered Non-Fibrillar Collagens in Human Dilated Cardiomyopathy: Role in the Remodeling Process.

Gil-Cayuela C, Roselló-LLetí E, Ortega A, Tarazón E, Triviño JC, Martínez-Dolz L, González-Juanatey JR, Lago F, Portolés M, Rivera M.

PLoS One. 2016 Dec 9;11(12):e0168130.

1932-6203

3,057 Q1 -

Lymphatic Targeting of Nanosystems for Anticancer Drug Therapy.

Abellan-Pose R, Csaba N, Alonso MJ. Curr Pharm Des.

2016;22(9):1194-209.

1381-6128

3,052 Q2 -

High-resolution copy number analysis of paired normal-tumor samples from diffuse large B cell lymphoma.

Sebastián E, Alcoceba M, Martín-García D, Blanco Ó, Sanchez-Barba M, Balanzategui A, Marín L, Montes-Moreno S, González-Barca E, Pardal E, Jiménez C, García-Álvarez M, Clot G, Carracedo Á, Gutiérrez NC, Sarasquete ME, Chillón C, Corral R, Prieto-Conde MI, Caballero MD, Salaverria I, García-Sanz R, González M.

Ann Hematol.

2016 Jan;95(2):253-62.

0939-5555

3,022 Q2 -

Anti-inflammatory effect of conditioned medium from human uterine cervical stem cells in uveitis.

Bermudez MA, Sendon-Lago J, Seoane S, Eiro N, Gonzalez F, Saa J, Vizoso F, Perez-Fernandez R.

Exp Eye Res. 2016 Aug;149:84-92.

0014-4835

2,998 Q1 -

31


Anti-inflammatory effect of conditioned medium from human uterine cervical stem cells in uveitis

Bermudez MA, Sendon-Lago J, Seoane S, Eiro N, Gonzalez F, Saa J, Vizoso F, Perez-Fernandez R.

Exp Eye Res 2016 Aug;149:84-92.

0014-4835

2,998 Q1 -

Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics.

Kaczor AA, Silva AG, Loza MI, Kolb P, Castro M, Poso A.

ChemMedChem.

2016 Apr 5;11(7):718-29.

1860-7179

2,980 Q1 -

2D-DIGE-based proteomic analysis of intracoronary versus peripheral arterial blood platelets from acute myocardial infarction patients: Upregulation of platelet activation biomarkers at the culprit site.

Vélez P, Ocaranza-Sánchez R, López-Otero D, Grigorian-Shamagian L, Rosa I, Bravo SB, González-Juanatey JR, García Á.

Proteomics Clin Appl.

2016 Aug;10(8):851-8.

1862-8346

2,959 Q2 -

Platelet clinical proteomics: Facts, challenges, and future perspectives.

García Á. Proteomics Clin Appl.

2016 Aug;10(8):767-73.

1862-8346

2,959 Q2 -

Key structural and functional differences between early and advanced glycation products.

Paradela-Dobarro B, Rodiño-Janeiro BK, Alonso J, Raposeiras-Roubín S, González-Peteiro M, González-Juanatey JR, Álvarez E.

J Mol Endocrinol.

2016 Jan;56(1):23-37.

0952-5041

2,947 Q3 -

Food Addiction in Bulimia Nervosa: Clinical Correlates and Association with Response to a Brief Psychoeducational Intervention.

Hilker I, Sánchez I, Steward T, Jiménez-Murcia S, Granero R, Gearhardt AN, Rodríguez-Muñoz RC, Dieguez C, Crujeiras AB, Tolosa-Sola I, Casanueva FF, Menchón JM, Fernández-Aranda F.

Eur Eat Disord Rev.

2016 Nov;24(6):482-488.

1072-4133

2,912 Q1 -

Inference of biogeographical ancestry across central regions of Eurasia.

Bulbul O, Filoglu G, Zorlu T, Altuncul H, Freire-Aradas A, Söchtig J, Ruiz Y, Klintschar M, Triki-Fendri S, Rebai A, Phillips C, Lareu MV, Carracedo Á, Schneider PM.

Int J Legal Med.

2016 Jan;130(1):73-9. doi: 10.1007/s00414-015-1246-7. PubMed PMID: 26289413.

0937-9827

2,862 Q1 -

Human Uterine Cervical Stromal Stem Cells (hUCESCs): Why and How they Exert their Antitumor Activity.

Schneider J, Eiró N, Pérez-Fernández R, Martínez-Ordóñez A, Vizoso F.

Cancer Genomics Proteomics.

2016 09-10;13(5):331-7. Review.

1109-6535

2,800 Q2 -

32


PRKG1 and genetic diagnosis of early-onset thoracic aortic disease. Eur

Gago-Díaz M, Blanco-Verea A, Teixidó G, Huguet F, Gut M, Laurie S, Gut I, Carracedo Á, Evangelista A, Brion M.

Eur J Clin Invest.

2016 Sep;46(9):787-94.

0014-2972

2,687 Q1 -

Sea cucumbers with an anti-inflammatory effect on endothelial cells and subcutaneous but not on epicardial adipose tissue.

Mena-Bueno S, Atanasova M, Fernández-Trasancos Á, Paradela-Dobarro B, Bravo SB, Álvarez E, Fernández ÁL, Carrera I, González-Juanatey JR, Eiras S.

Food Funct. 2016 Feb;7(2):953-63.

2042-6496

2,686 Q1 -

Activation of PKA and Epac proteins by cyclic AMP depletes intracellular calcium stores and reduces calcium availability for vasoconstriction.

Cuíñas A, García-Morales V, Viña D, Gil-Longo J, Campos-Toimil M.

Life Sci. 2016 Jun 15;155:102-9.

0024-3205

2,685 Q2 -

Strong genetic structure revealed by multilocus patterns of variation in Giardia duodenalis isolates of patients from Galicia (NW-Iberian Peninsula).

Gabín-García LB, Bartolomé C, Abal-Fabeiro JL, Méndez S, Llovo J, Maside X.

Infect Genet Evol.

2016 Dec 16;48:131-141.

1567-7257

2,591 Q2 0

Comprehensive molecular testing in patients with high functioning autism spectrum disorder.

Alvarez-Mora MI, Calvo Escalona R, Puig Navarro O, Madrigal I, Quintela I, Amigo J, Martinez-Elurbe D, Linder-Lucht M, Aznar Lain G, Carracedo A, Mila M, Rodriguez-Revenga L.

Mutat Res. 2016 Feb-Mar;784-785:46-52.

0027-5107

2,581 Q2 -

Change of concept about the regulation of angiotensin II-induced monocyte chemoattractant protein-1 production in human endothelial cells.

Castiñeiras-Landeira MI, Rodiño-Janeiro BK, Paradela-Dobarro B, Batista-Oliveira AL, Raposeiras-Roubín S, González-Peteiro M, González-Juanatey JR, Álvarez E.

Vascul Pharmacol.

2016 May;80:20-34.

1537-1891

2,500 Q2 -

Food Addiction in Patients with Eating Disorders is Associated with Negative Urgency and Difficulties to Focus on Long-Term Goals.

Wolz I, Hilker I, Granero R, Jiménez-Murcia S, Gearhardt AN, Dieguez C, Casanueva FF, Crujeiras AB, Menchón JM, Fernández-Aranda F.

Front Psychol.

2016 Feb 2;7:61.

1664-1078

2,463 Q1 -

LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A.

Tu Y, Sánchez-Iglesias S, Araújo-Vilar D, Fong LG, Young SG.

Nucleus. 2016 Sep 2;7(5):512-521.

1949-1034

2,446 Q3 -

33


The Priority position paper: Protecting Europe's food chain from prions.

Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I.

Prion. 2016 May 3;10(3):165-81.

1933-6896

2,444 Q3 -

Mehran contrast nephropathy risk score: Is it still useful 10 years later?

Abellás-Sequeiros RA, Raposeiras-Roubín S, Abu-Assi E, González-Salvado V, Iglesias-Álvarez D, Redondo-Diéguez A, González-Ferreiro R, Ocaranza-Sánchez R, Peña-Gil C, García-Acuña JM, González-Juanatey JR.

J Cardiol. 2016 Mar;67(3):262-7.

0914-5087

2,405 Q2 -

Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns.

Digles D, Zdrazil B, Neefs JM, Van Vlijmen H, Herhaus C, Caracoti A, Brea J, Roibás B, Loza MI, Queralt-Rosinach N, Furlong LI, Gaulton A, Bartek L, Senger S, Chichester C, Engkvist O, Evelo CT, Franklin NI, Marren D, Ecker GF, Jacoby E.

Medchemcomm.

2016 Jun 1;7(6):1237-1244.

2040-2503

2,319 Q3 -

Development of a Multiplex Assay for Studying Functional Selectivity of Human Serotonin 5-HT2A Receptors and Identification of Active Compounds by High-Throughput Screening.

Iglesias A, Lage S, Cadavid MI, Loza MI, Brea J. J Biomol Screen.

2016 Sep;21(8):816-23.

1087-0571

2,218 Q2 -

Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico.

Sesar A, Cacheiro P, López-López M, Camiña-Tato M, Quintáns B, Monroy-Jaramillo N, Alonso-Vilatela ME, Cebrián E, Yescas-Gómez P, Ares B, Rivas MT, Castro A, Carracedo A, Sobrido MJ.

J Neurol Sci. 2016 Mar 15;362:321-5.

0022-510X

2,126 Q3 -

Polymeric nanocapsules: a potential new therapy for corneal wound healing.

Reimondez-Troitiño S, Alcalde I, Csaba N, Íñigo-Portugués A, de la Fuente M, Bech F, Riestra AC, Merayo-Lloves J, Alonso MJ.

Drug Deliv Transl Res.

2016 Dec;6(6):708-721. PubMed PMID: 27392604.

2190-393X

1,887 Q3 -

34


Genetic structure of the Kuwaiti population revealed by paternal lineages.

Triki-Fendri S, Sánchez-Diz P, Rey-González D, Alfadhli S, Ayadi I, Ben Marzoug R, Carracedo Á, Rebai A.

Am J Hum Biol.

2016 Mar-Apr;28(2):203-12.

1042-0533

1,875 Q2 -

Spatial Frequency Components of Images Modulate Neuronal Activity in Monkey Amygdala.

Montes-Lourido P, Bermudez MA, Romero MC, Vicente AF, Gonzalez F.

Perception. 2016 Apr;45(4):375-85.

2041-6695

1,813 Q3 -

Gene-gene interactions between DRD3, MRP4 and CYP2B6 polymorphisms and its influence on the pharmacokinetic parameters of efavirenz in HIV infected patients.

Sánchez-Martín A, Cabrera Figueroa S, Cruz R, Porras-Hurtado L, Calvo-Boyero F, Rasool M; Tormes Team., Domínguez-Gil Hurlé A, Carracedo A.

Drug Metab Pharmacokinet.

2016 Oct;31(5):349-355.

1347-4367

1,764 Q3 -

BleeMACS: rationale and design of the study. D'Ascenzo F, Abu-Assi E, Raposeiras-Roubín S, Simao Henriques JP, Saucedo J, González-Juanatey JR, Wilton SB, Kikkert WJ, Nuñez-Gil I, Ariza-Sole A, Song X, Alexopoulos D, Liebetrau C, Kawaji T, Moretti C, Huczek Z, Nie SP, Fujii T, Correia LC, Kawashiri MA, García-Acuña JM, Southern D, Alfonso E, Terol B, Garay A, Zhang D, Chen Y, Xanthopoulou I, Osman N, Möllmann H, Shiomi H, Giordana F, Scarano S, Gaita F, Kowara M, Filipiak KJ, Wang X, Yan Y, Fan JY, Ikari Y, Nakahayshi T, Sakata K, Yamagishi M, Kalpak O, Kedev S.

J Cardiovasc Med (Hagerstown).

2016 Oct;17(10):744-9.

1558-2027

1,658 Q3 -

Very brief training for laypeople in hands-only cardiopulmonary resuscitation. Effect of real-time feedback.

González-Salvado V, Fernández-Méndez F, Barcala-Furelos R, Peña-Gil C, González-Juanatey JR, Rodríguez-Núñez A.

Am J Emerg Med.

2016 Jun;34(6):993-8.

0735-6757

1,504 Q2 -

Assessment of Corneal Epithelial Thickness in Asymmetric Keratoconic Eyes and Normal Eyes Using Fourier Domain Optical Coherence Tomography.

S. Catalan, L. Cadarso, F. Esteves, J. Salgado-Borges, M. Lopez, and C. Cadarso.

Journal of Ophthalmology. (2016).

2016 Volume 5697343

2090-004X

1,463 Q3 -

35


Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.

Garcia-Rua V, Feijoo-Bandin S, Garcia-Vence M, Aragon-Herrera A, Bravo SB, Rodriguez-Penas D, Mosquera-Leal A, Lear PV, Parrington J, Alonso J, Rosello-Lleti E, Portoles M, Rivera M, Gonzalez-Juanatey JR, Lago F.

J Biosci. 2016 Dec;41(4):643-658.

0250-5991

1,419 Q2 -

Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome.

Yan Y, Wang X, Fan JY, Nie SP, Raposeiras-Roubín S, Abu-Assi E, Henriques JP, D'Ascenzo F, Saucedo J, González-Juanatey JR, Wilton SB, Kikkert WJ, Nuñez-Gil I, Ariza-Sole A, Song XT, Alexopoulos D, Liebetrau C, Kawaji T, Moretti C, Huczek Z, Fujii T, Correia LC, Kawashiri MA, Kedev S.

J Geriatr Cardiol.

2016 Mar;13(3):209-17.

1671-5411

1,393 Q3 -

The Molecular Registry of Pituitary Adenomas (REMAH): A bet of Spanish Endocrinology for the future of individualized medicine and translational research.

Luque RM, Ibáñez-Costa A, Sánchez-Tejada L, Rivero-Cortés E, Robledo M, Madrazo-Atutxa A, Mora M, Álvarez CV, Lucas-Morante T, Álvarez-Escolá C, Fajardo C, Castaño L, Gaztambide S, Venegas-Moreno E, Soto-Moreno A, Gálvez MÁ, Salvador J, Valassi E, Webb SM, Picó A, Puig-Domingo M, Gilabert M, Bernabéu I, Marazuela M, Leal-Cerro A, Castaño JP; investigadores del REMAH..

Endocrinol Nutr.

2016 Jun-Jul;63(6):274-84.

1575-0922

1,314 Q4 -

Endothelial progenitor cells mobilisation after percutaneous coronary intervention: a pilot study.

Santas-Álvarez M, Rodiño-Janeiro BK, Paradela-Dobarro B, López-Otero D, Viñuela-Roldán JE, Castiñeiras-Landeira MI, González-Juanatey JR, Trillo-Nouche R, Álvarez E.

Br J Biomed Sci.

2016 Oct;73(4):194-200.

0967-4845

1,245 Q3 -

Confidence intervals for the symmetry point: an optimal cutpoint in continuous diagnostic tests.

López-Ratón M, Cadarso-Suárez C, Molanes-López EM, Letón E.

Pharm Stat. 2016 Mar-Apr;15(2):178-92.

1539-1604

1,235 Q2 -

Alcohol and breast cancer tumor subtypes in a Spanish Cohort.

Gago-Dominguez M, Castelao JE, Gude F, Fernandez MP, Aguado-Barrera ME, Ponte SM, Redondo CM, Castelo ME, Dominguez AN, Garzón VM, Carracedo A, Martínez ME.

Springerplus.

2016 Jan 16;5:39.

2193-1801

0,982 Q2 -

36


Time-dependent ROC methodology to evaluate the predictive accuracy of semiparametric multi-state models in the presence of competing risks: An application to peritoneal dialysis programme

Laetitia Teixeira; Carmen Cadarso Suárez; Anabela Rodrigues; Denisa Mendonça.

Statistical Modelling

2016; 16 (5) 409-428

1471-082X

0,932 Q2 -

[2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure].

Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P.

Kardiol Pol. 2016;74(10):1037-1147.

0022-9032

0,878 Q4 -

Bioresorbable scaffold adjustment in an ostial lesion with the Szabo technique.

Galvão Braga C, Ocaranza-Sánchez R, Gestal S, Trillo R, González-Juanatey JR.

Rev Port Cardiol.

2016 Nov;35(11):623-625.

0870-2551

0,873 Q4 -

Optical coherence tomography images of three different overlapping stents.

Abellás-Sequeiros RA, Ocaranza-Sánchez R, Trillo-Nouche R, González-Juanatey JR.

Rev Port Cardiol.

2016 Jul-Aug;35(7-8):453-4.

0870-2551

0,873 Q4 -

Permanent junctional reciprocating tachycardia in a patient with an atypically located accessory pathway in the left lateral mitral annulus.

Rodríguez-Mañero M, Fernández-López XA, González-Melchor L, García-Seara J, Martínez-Sande JL, González-Juanatey JR.

Rev Port Cardiol.

2016 Jan;35(1):59.e1-5.

0870-2551

0,873 Q4 -

Reply to the letter "Radiofrequency ablation and predictors for faster recovery for tachycardia-induced cardiomyopathy in the pediatric population".

Rodríguez-Mañero M, García-Seara J, Martínez-Sande JL, González-Juanatey JR.

Rev Port Cardiol.

2016 Nov;35(11):631-632.

0870-2551

0,873 Q4 -

Clinical considerations on the posology of direct oral anticoagulants.

Sáez-Peñataro J, Avendaño-Solá C, González-Juanatey JR.

Rev Clin Esp.

2016 Oct;216(7):384-392.

0014-2565

0,760 Q3 -

Consensus document and recommendations on the use of natriuretic peptides in clinical practice.

Pascual-Figal DA, Casademont J, Lobos JM, Piñera P, Bayés-Genis A, Ordóñez-Llanos J, González-Juanatey JR.

Rev Clin Esp.

2016 Aug-Sep;216(6):313-22.

0014-2565

0,760 Q3 -

Visual Perception in Anterior Temporal Lobectomy. Romero MC, Lozano M, Montes-Lourido P, Bermudez MA, Vicente AF, Prieto A, Gonzalez F.

J Neurol Surg A Cent Eur Neurosurg.

2016 Mar;77(2):118-29.

2193-6315

0,723 Q4 -

37

b. Books And Book Chapters:

Book Title Editor Editorial City ISBN Pages Book Title Autor/es Paxina Inicio-Fin

Cavidad Anoftálmica y Protesis Oculares

R. Fernandez Hermida y B. Berasategui Fernandez

Mac Line Madrid. 978-84-936943-8-8

- El paciente monoftálmico Gonzalez

F, Abalo-Lojo JM

17-26

Cavidad Anoftálmica y Protesis Oculares

R. Fernandez Hermida y B. Berasategui Fernandez

Mac Line Madrid. 978-84-936943-8-8

- El ojo ciego doloroso Abalo-Lojo

JM, Gonzalez F.

27-34

Advances and challenges in the oral delivery of macromolecules

Greg Russell-Jones Future Science Ltd, Unitec House

London 978-1-

910419-

26-7

164 New perspectives in oral peptide and protein delivery: from nanocarrier design to in vivo effectiveness

Alonso-Sande M., Csaba N., Alonso M.J.

46-64

EL SÍNDROME DE WEST: ABORDAJE DESDE LAS CIENCIAS SOCIALES Y DE LA SALUD

Miguel Angel Barber, Agustín Legido, Nuria Pombo

Fundación Síndrome de West

468 ACCIONES A NIVEL CEREBRAL DEL TRIPÉPTIDO N-TERMINAL DE IGF-1.¿PUEDE SER DE UTILIDAD EN EL AUTISMO?

Jesús Devesa, Cristina Almengló, Pablo Devesa, Víctor Arce

311-328

39

3. TECHNOLOGY TRANSFER

In addittion to the contracts listed previously, we would like to highlight

the following items:

a. Partnership with the Industry

Join Research Unit SunRock Biopharma-CiMUS: Since July

of 2016

Join Research Unit Biopharma-Esteve:

GSK-Fast Track: The PIs, Mabel Loza and Ángel Carracedo,

coordinators of the Innopharma Farmacogenomic Platform

were selected by the Discovery Partnerships with Academia

Programe from GSK, as one of the 6 winners of the Discovery

Fast Track. They were selected from 378 proposals from 21

countries all over Europe and Noth America.

b. Spin Offs/ Foundation/new ventures:

KERTOR Foundation: This foundation is a follow-up of the

INNOPHARMA project. It is envisage as a new instrument

that will allow a speedy development of projects in

partnership with industry.

GenDR. This project is focused in developing a platform

offering know-how in the field of pharmacogenomics. It has

received the following prizes: Argos Spin(Argos Program from

USC), Model2Market Universia Prize(Spin2016) and Best Business

Idea (2016, Revista Emprendedores).

SADVIA. This project is focused in providing scientific advice

to the companies in order to be a bridge between them and

the research university groups. It was awarded with the prize

“Santander YUZZ Woman 2016” from the program for

entrepreuners Santander Yuzz

40

BIOSTATECH. This spin-off frm the group of Biostatistics is

now fully consolidated increasing year after their portfolio of

clients and income.

41

c. Patents

NEW Patent applications (OEPM)

Year Application number Application Date Title GI Status Under exploitation

20

16

P201630565 02/05/2016 Andamiaje biodegradable que comprende un

ARN mensajero 1643

In process OEPM

No

P201631221 19/09/2016 Nanopartículas con interiores protegidos, y

métodos de uso de las mismas 1643

In process OEPM

No

International extension of previous applications (previous priority)

Year Application

number Application Date Title GI Status

Under exploitation

Priority application no.

20

16

PCT/EP2016/060104 04/05/2016

RIBOFLAVIN FOR THE TREATMENT OF ISCHEMIC STROKE AND/OR OTHER

GLUTAMATE EXCITOTOXICITY- ASSOCIATED DISEASES

1685 In Process PCT No EP15382229

US15/038,303 20/05/2016 Vitamin D analogues of pharmaceutical interest

2105 In process USA NO P201331689

42

EP14864477.6 03/06/2016 Vitamin D analogues of pharmaceutical interest

2105 In process EPO NO P201331689

PCT/ES2016/070637 09/09/2016

MÉTODO PARA LA SEPARACIÓN DE LA FRACCIÓN UNIDA A

GLUCOSAMINOGLICANOS Y SUS APLICACIONES

1736 In process PCT No

P201531297

Registration of previous applications

Año Office Registration no. Registration

Date Title GI

Under exploitation

Priority application no.

20

16

USA ES2481940 B1 16/08/2016 Nanocapsules with a polymer shell 1643 NO P201130015

OEPM ES2536256 B2 25/01/2016 Análogos de Vitamina D con interés

farmacéutico 2105 NO P201331689

OEPM ES2544869 B2 11/01/2016 Derivados de piridazin-3(2H)-ona

inhibidores selectivos de la isoforma B de la monoaminooxidasa

1683 NO P201400162

43

8,84%

61,74%

11,15%

13,27%

5,00%

New funding 2016

International

National

Regional

Contracts

Agreements

€-

€1.000.000

€2.000.000

€3.000.000

€4.000.000

€5.000.000

€6.000.000

Projects Contracts Agreements

NEW funding 2016

International

National

Regional

4. FINANCIAL RESOURCES. In addittion to a structural grant from the Xunta de

Galicia ( total amount 0f 322.289,47 €), the following funding was obtained:

a. 2016 New Funding

Scope Amount Percentage N

Projects

International 551.375,00 € 8,84% 1

National 3.848.940,00 € 61,74% 18

Regional 695.000,00 € 11,15% 5

Company´s contracts 826.967,76 € 13,27% 79

Agreements 311.820,39 € 5% 11

TOTAL 6.448.085,44 € 100,0% 114

44

Title PI Call/Entity Start date End date Total Amount €

Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)

Alonso Fernández, María José

EUROPEAN UNION

29/11/2016 31/12/2021 551.375 €

AMPK hipotalámica y balance energético. - RETOS 2015

Miguel A. López Pérez

MINISTERIO DE ECONOMIA Y COMPETITIVIDAD

01/01/2016 31/12/2018 363.000 €

Metabolismo de las células tumorales y AMPK. Talón de Aquiles y nueva diana terapéutica en los astrocitomas cerebrales. - AES 2015

Señarís Rodríguez, Rosa María

INSTITUTO DE SALUD CARLOS III

01/01/2016 31/12/2018 110.715 €

Papel de p53 y p63 hepáticos en la homeostasis metabólica. Implicaciones en desórdenes asociados a obesidad. - RETOS 2015

Rubén Nogueiras


01/01/2016 31/12/2018 242.000 €

Pit-1, vitamina D y estroma en cáncer de mama. - RETOS 2015

Román Pérez Fernández


01/01/2016 31/12/2018 133.100 €

Sistema renina-angiotensina cerebral en neuroinflamación y degeneración dopaminérgica. Más allá del eje AII/AT1/NADPH-OXIDASA. - EXCELENCIA 2015

José Luis Labandeira García


01/01/2016 31/12/2018 296.450 €

Prevencion, detección precoz, tratamiento y rehabilitación de las patologías oculares (Oftared)

Francisco Gonzalez Garcia

RETICS, ISCIII 01/01/2016 31/12/2020 25.476€

Coste-efectividad y coste utilidad de una estrategia de transfusión de hematíes " "liberal" vs. otra " restrictiva" en pacientes con infarto

Abu Assi, Emad (Jose Ramón González Juanatey)

Instituto de Salud Carlos III

01/01/2016 31/12/2018 38.115 €

Estudio del papel de la relaxina sobre la regulación del metabolismo y autofagia cardiomiocitarios. Implicaciones en la fisiopatología de las enfermedades cardiometabólicas.

Francisca Lago Paz.


01/01/2016 31/12/2018 96.800 €

Desarrollo de tratamientos personalizados para el glaucoma. Énfasis en poblaciones infantiles y de edad avanzada. GLAUKUS. RETOS-COLABORACIÓN 2016


AGENCIA ESTATAL DE INVESTIGACION

07/03/2016 31/12/2018 140.140

Soluciones innovadoras para el tratamiento del ojo seco combinado con dolor ocular - SEKEYE. RETOS-COLABORACIÓN 2016



07/03/2016 31/12/2018 209.160

Definición de mecanismos clave de la multiresistencia de tumores

Carracedo Álvarez, Ángel

AECC 22/09/2016 31/12/2022 1.200.000 €

45

de cabeza y cuello a los tratamientos quimio- y radioterapéuticos. Identificación de nuevos antitumorales individualizados

María

Papel de p63 hepático en el control del metabolismo de glucosa y señalización de insulina

Nogueiras Pozo, Rubén

FUNDACION ASTRAZENECA

26/10/2016 25/10/2017 20.000 €

Análisis de la acción conjunta de la familia de proteínas Ten-elevaen translocation y las proteínas con bromo dominios durante la generación de células pluripotentes inducida. EXCELENCIA 2016

Fidalgo Pérez, Miguel Ángel


30/12/2016 29/12/2019 193.600 €

Efecto sobre el metabolismo energético y termogénesis de SIRT1 y SIRT3 en BAT en estados de resistencia a la insulina inducida por HFD y en el envejecimiento. RETOS 2016

Tovar Carro, Sulay A.


30/12/2016 29/12/2020 133.100 €

Estudio bioquímico del procesado de los intermediarios de la replicación y la recombinación del ADN. EXCELENCIA 2016

González Blanco, Miguel


30/12/2016 29/12/2019 181.500 €

Impacto de la obesidad en la reactividad de las plaquetas en la enfermedad coronaria: análisis bioquímico y funcional. RETOS 2016

García Alonso, Ángel


30/12/2016 29/12/2019 140.360 €

Implicaciones fisiopatológicas de los mecanismos de recambio y proliferación, benigna y maligna, de las células foliculares tiroideas humanas y de glándulas endocrinas. RETOS 2016

Álvarez Villamarín, M. Clara


30/12/2016 29/12/2019 254.100 €

Nueva estrategia multi-etapa para la liberación oral de biomacromoléculas terapéuticas. RETOS 2016

Csaba, Noemí Stefanía


30/12/2016 29/12/2019 96.800

Consolidación e estruturación - MODALIDADE D 2016


CONSELLERIA DE CULTURA, EDUCACION E ORDENACION UNIVERSITARIA

01/01/2016 30/11/2020 115.000

Consolidación e estruturación -MODALIDADE D 2016



01/01/2016 30/11/2019 90.000

46




01/01/2016 30/11/2019 90.000


López Pérez, Miguel Antonio


05/11/2016 30/11/2020 200.000




05/11/2016 30/11/2020 200.000

TOTAL 5.095.315, €

Title IP Call/Entity Start date End date Total

Amount €

Obtaining 60 hamster scraie 263k infected brains

Jesús Rodríguez Requena

MICROBAC LABORATORIES, INC.

14/01/2016 30/07/2016 18.675,54 €

NEOGALFARMA- Nuevos fármacos contra el cáncer: Desarrollo de terapias dirigidas a diferentes dianas terapéuticas y de tratamientos combinados. Conecta-Peme 2016

Loza García, María Isabel

ONCOSTELLAE, S.L.

20/01/2016 30/11/2018 32.000,00



GALCHIMIA, S.A. 27/01/2016 30/11/2018 22.800,00

Consultancy on technical expertise on the pharmaceutical development of EG 1964


EDGE THERAPEUTICS, INC.

06/03/2016 07/03/2016 3.609,08

Confidentiality agreement Loza García, María Isabel

IDP DISCOVERY PHARMA, S.L.

08/03/2016 07/03/2026 0,00

Confidencial Disclosure Agreement: 'Purpose of determining interest in and pursuing business discussions relating to GSK site(s)'


GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO, S.L.

05/04/2016 04/04/2021 0,00

Confidentiality Agreement Alonso Fernández, María José

THE UNIVERSITY OF NOTTINGHAM

05/04/2016 04/04/2021 0,00

Acuerdo de Confidencialidad Diéguez BIOMEDICA 28/04/2016 27/04/2018 0,00

47

González, Carlos

MOLECULAR MEDICINE, S.L.

Protocolos experimentales detallados para ensayar compuestos con actividad farmacológica en ensayos de unicón a proteína plasmática y estabilidad en microsomas

María Isabel Loza García

ALMIRALL PRODESFARMA, S.A.

18/05/2016 17/05/2026 0,00 €


SAGETIS BIOTECH, S.L.

26/05/2016 25/05/2019 0,00

Acordo de Confidencialidade 'Spanish exome array content'

Carracedo Álvarez, Ángel María

AFFYMETRIX UK LTD

14/06/2016 13/06/2017 0,00

Test Biologically active COMPOUNDS in protein plasma, protein binding, phase I microsomal metabolism and plasma stability assays


ALMIRALL, S.A. 28/06/2016 30/06/2017 35.000,00

Convenio de Colaboración para el estudio sobre el desarrollo de nuevos sistemas de vehiculización y nuevos biomarcadores de personalización del tratamiento del cáncer

Diéguez González, Carlos

SUNROCK BIOPHARMA, S.L.

01/07/2016 31/12/2018 26.250,00

Acuerdo de confidencialidad Alonso Fernández, María José

ALMIRALL, S.A. 29/07/2016 28/07/2017 0,00

Mutual Confidential Disclosure Agreement


NOVARTIS CONSUMER HEALTH, S.A. (SWITZERLAND)

10/08/2016 09/08/2017 0,00

Mutual Confidential disclosure agreement


MERCK SHARP & DOHME CORP.

24/08/2016 23/08/2017 0,00

Non Disclosure agreement Alonso Fernández, María José

COLUMBUS VENTURE PARTNERS SGEIC, S.A.

06/10/2016 07/10/2021 0,00


PANGAEA BIOTECH, S.L.

18/11/2016 17/11/2019 0,00

Collaborative research agreement in the field of potential aplication of nanotechnologies in specific drug delivery



01/12/2016 01/12/2017 185.680,00

Acordo de Confidencialidade Loza García, María Isabel

BIOSTATECH, ADVICE,TRAINING & INNOVATION IN BIOSTATISTICS, S.L.

15/12/2016 14/12/2036 0,00

48

Non Disclosure Agreement 'development and production of mAbs for their use in testing innovative delivery technology'


PX'THERAPEUTICS SAS

19/12/2016 18/12/2018 0,00

Acuerdo de Mútuo de Confidencialidad


INDUSTRIAL FARMACEUTICA CANTABRIA, S.A.

29/12/2016 28/12/2026 0,00

Servizo de Xenotipado Carracedo Álvarez, Ángel María


01/01/2016 31/12/2020 15.486,91


CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB

01/01/2016 31/12/2020 6.249,79


FUNDACION PARA LA INVESTIGACION HOSPITAL GREGORIO MARAÑON

01/01/2016 31/12/2020 9.918,44


CENTER FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY

01/01/2016 31/12/2020 2.763,98


LABORATORIO DE ANALISIS CLINICAS DR. JOAQUIM CHAVES

01/01/2016 31/12/2020 1.404,25


FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

01/01/2016 31/12/2020 4.922,12


CONSORCIO DEL HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA

01/01/2016 31/12/2020 17.805,75


UNIVERSIDAD DE OVIEDO

01/01/2016 31/12/2020 9.159,58


INSTITUT D'INVESTIGACIONS BIOMEDIQUES AGUSTI PI I SUNYER (IDIBAPS)

01/01/2016 31/12/2020 5.331,69


FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT

01/01/2016 31/12/2020 550,28

49

VALENCIANA


IFAPA ALAMEDA DEL OBISPO

01/01/2016 31/12/2020 3.298,98


VALL D'HEBRON INSTITUTE OF ONCOLOGY - VHIO

01/01/2016 31/12/2020 4.944,26


FUNDACION PUBLICA ANDALUZA PARA LA INVESTIGACION DE MALAGA EN BIOMEDICINA Y SALUD (FIMABIS)

01/01/2016 31/12/2020 15.019,35


INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA (INIA)

01/01/2016 31/12/2020 367,72


CENTRO DE INVESTIGACION BIOMEDICA EN RED - CIBER

01/01/2016 31/12/2020 38.933,29


FUNDACION INSTITUTO DE INVESTIGACION SANITARIA ARAGON

01/01/2016 31/12/2020 11.683,12


INSTITUT DE RECERCA BIOMEDICA DE LLEIDA

01/01/2016 31/12/2020 1.659,06


FUNDACION CANARIA DE INVESTIGACION SANITARIA (FUNCANIS)

01/01/2016 31/12/2020 3.007,62


MAKING GENETICS, S.L.

01/01/2016 31/12/2020 1.214,78


INSTITUTO DE MEDICINA PREDICTIVA Y PERSONALIZADA DEL CANCER

01/01/2016 31/12/2020 2.522,41

50


INSTITUTO DE INVESTIGACION MARQUES DE VALDECILLA - IDIVAL

01/01/2016 31/12/2020 1.261,00


MG NUTRICION 3G

01/01/2016 31/12/2020 2.420,58


UNIVERSIDAD DE SEVILLA

01/01/2016 31/12/2020 5.769,62


NORWEGIAN INSTITUTE OF PUBLIC HEALTH (NIPH)

01/01/2016 31/12/2020 784,94


UNIVERSITAT JAUME I

01/01/2016 31/12/2020 2.972,75


CLINICA UNIVERSIDAD DE NAVARRA

01/01/2016 31/12/2020 2.776,68


UNIVERSIDAD DE BARCELONA

01/01/2016 31/12/2020 10.507,09


FUNDACION RAMON DOMINGUEZ

01/01/2016 31/12/2020 17.491,12


INSTITUTO DE MEDICINA ONCOLOGICA Y MOLECULAR DE ASTURIAS

01/01/2016 31/12/2020 420,24


FUNDACIO ACE. INSTITUT CATALA DE NEUROCIENCIAS

01/01/2016 31/12/2020 939,95


HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS

01/01/2016 31/12/2020 8.612,74


INSTITUT D'INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL

01/01/2016 31/12/2020 2.522,41


UNIVERSIDAD AUTONOMA DE CHILE

01/01/2016 31/12/2020 672,22


FUNDACION INVESTIGACION BIOMEDICA HOSPITAL

01/01/2016 31/12/2020 1.314,97

51

CLINICO SAN CARLOS


F. PUBLICA GALEGA DE MEDICINA XENOMICA

01/01/2016 31/12/2020 57.182,05


REFERENCE LABORATORY

01/01/2016 31/12/2020 2.031,26


IGENOMIX S.L. 01/01/2016 31/12/2020 1.378,04


BANCO NACIONAL DE ADN CARLOS III

01/01/2016 31/12/2020 1.018,43


INSTITUTO CAJAL - CSIC

01/01/2016 31/12/2020 2.351,62


FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

01/01/2016 31/12/2020 21.416,34


MAX PLANCK INSTITUTE FOR PLANT BREEDING RESEARCH

01/01/2016 31/12/2020 12.600,00


UNIVERSIDAD POLITECNICA DE VALENCIA

01/01/2016 31/12/2020 735,42

Plataforma: Unidade de Screening


LILLY, S.A. 01/01/2016 31/12/2020 21.739,00



ELI LILLY AND COMPANY

01/01/2016 31/12/2020 87.655,00



UNIVERSIDAD DE BURGOS

01/01/2016 31/12/2020 1.440,00



LANDSTEINER GENMED, S.L.

01/01/2016 31/12/2020 19.498,33



UNILEVER CENTRE FOR MOLECULAR SCIENCES INFORMATICS

01/01/2016 31/12/2020 2.240,00



UNIVERSIDADE DE VIGO

01/01/2016 31/12/2020 381,50



INSTITUTO DE SINTESIS QUIMICA Y CATALISIS HOMOGENEA - CSIC

01/01/2016 31/12/2020 1.800,00



UNIVERSIDAD DE CASTILLA LA MANCHA

01/01/2016 31/12/2020 540,00

52

Plataforma: Servizo de Secuenciación



01/01/2016 31/12/2020 129,02

Prestación de servizos de animalario aos investigadores do CIMUS



01/01/2016 31/12/2020 15.590,50



FUNDACION BIOMEDICA GALICIA SUR

01/01/2016 31/12/2020 3.813,75



NANOIMMUNOTECH,S.L.

01/01/2016 31/12/2020 2.563,19

Servizo de Farmacoxenómica (FARMAXEN)


LILLY, S.A. 01/01/2016 31/12/2020 32.140,00

TOTAL 826.967,76 €

Title PI Call/Entity Start date End date Total

Amount €

Material Transfer Agreement: 'Compound UB, with putative SEH inhibitory activity'



01/01/2016 31/12/2020 0,00

Radiogenómica: evaluación de variantes raras asociadas a toxicidad radioinducida e identificación de variantes causales mediante Fine-mapping.

Ángel Carracedo Álvarez


15/01/2016 03/02/2016 74.793,89 €

Determinación de biomarcadores: Análisis muestras aspirado sangre, pezón y orina



01/03/2016 31/12/2016 31.921,00 €

Material Transfer Agreement (Order 256926)


ADDGENE 07/03/2016 06/03/2021 0,00

Determinantes clínicos y neurobiológicos de segundos episodios de esquizofrenia. Estudio longitudinal de primeros episodios psicóticos.



22/03/2016 10/06/2016 49.958,32 €

Genotipado de 900 muestras de ADN mediante tecnología IPLEX GOLD de Agena Bioscience (antes Sequenom)



18/04/2016 17/07/2016 12.089,92 €




18/04/2016 17/07/2016 0,00

53

Convenio de Colaboración para la realización del proyecto: Células madre uterinas en el tratamiento del cáncer y otras patologías


FUNDACION PARA LA INVESTIGACION CON CELULAS MADRE UTERINAS (FICEMU)

01/05/2016 30/04/2017 3.200,00 €


Pérez Fernández, Román


01/05/2016 31/05/2017 18.700,00

servicio de xenotipado Carracedo Álvarez, Ángel María

UNIVERSITAT POMPEU FABRA

19/05/2016 18/05/2017 25.203,56

Farmacocinética, biodistribución y respuesta terapéutica de nanocápsulas / nanoemulsiones funcionalizadas y cargadas con docetaxel en un modelo murino de carcinoma ortópico de pulmón


UNIVERSIDAD DE NAVARRA

22/06/2016 30/10/2016 0,00

Construcción de un array de variación funcional en exornas de la población española: búsqueda de genes implicados en el cáncer colorrectal y en respuesta al tratamiento quimioteráptico (PI13/01136)



28/09/2016 27/01/2017 114.653,70

TOTAL 311.820,39 €

Infrastructures CiMUS

Call/Entity Start date

End date

Total Amount

€

Plataforma bioanalitica - INFRAESTRUCTURAS 2015



01/01/2016 31/12/2017 303.173,09

54

50%

28%

10%

8% 4%

ACTIVE Funding 2016

International

National

Regional

Contracts

Agreements

€-

€5.000.000

€10.000.000

€15.000.000

€20.000.000

€25.000.000

€30.000.000

Projects Contracts Agreements

ACTIVE Funding 2016

International

National

Regional

b. 2015 Active

Scope Amount Percentage Nº

Projects

International 15.579.432,83 € 49,59% 27

National 8.929.339,40 € 28,42% 50

Regional 3.218.598,85 € 10,24% 13

Company´s contracts 2.528.977,76 € 8,05% 73

Agreements 1.162.338,82 € 3,70% 17

Others (MTA, Confidential agreements, etc) - - 26

TOTAL 31.694.766,95 € 100,0% 206

55

Title PI Call/Entity Start date End date Total

Amount €

An open, integrated and sustainable chemistry, biology and pharmacology knowledge resource for drug discovery (OPENPHACTS)


COMISION EUROPEA

01/03/2011 29/02/2016 331.760 €

Hypothalamic Lipotoxicity and Endoplasmic Reticulum Stress: a New Pathophysiological Mechanism of Obesity (ObERStress)


VII PM - Ideas 01/12/2011 30/11/2016 1.484.000 €

p53 as a New Mediator of Energy Balance in the Brain (OBESITY53)


VII PM - Ideas 01/12/2011 30/11/2016 1.477.680 €

European Forensic Genetics Network of Excelellence (EUROFORGEN-NoE)


VII PM - Cooperación

01/01/2012 31/12/2016 546.831 €

New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier (TRANS-INT)



01/05/2012 30/04/2017 1.133.124 €

New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier (TRANS-INT)



01/05/2012 30/04/2017 276.102 €

NanoFar: European Doctorate in nanomedicine and pharmaceutical innovation


COMISION EUROPEA

01/10/2012 30/09/2019 1.109.800 €

The Human Early-Life Exposome - novel tools for integrating early-life environmental exposures and child health across Europe (HELIX)



01/01/2013 30/06/2017 326.227 €

Fabrication and Functionalization of Biomedical Microdevices (FaBiMed)

González Juanatey, José Ramón (líder de nodo)

Unión Europea (FP7)

01/09/2013 01/09/2016 79.520 €

Deciphering inter- and intracellular signalling in schizophrenia (IN-SENS)

Rodríguez Requena, Jesús

COMISION EUROPEA

01/10/2013 30/09/2017 226.681,62 €

PHYLOCANCER: Phylogeographic and somatic evolution of cancer tumor cells

Posada González, David

COMISION EUROPEA

01/01/2014 31/12/2018 1.999.899,60 €

Nano Inmuno Chemotherapy” (NICHE)

María José Alonso

EuroNanoMed 01/02/2014 01/02/2017 478.850 €

A Novel HIV-1 Vaccine Targeting the 12 protease Cleavage Sites


UNIVERSITY OF MANITOBA

13/06/2014 31/05/2017 184.727,52 €

56

A pilot plant for the production of Polymer based nanopharmaceuticals in compliance with GMP (NANO PILOT)


COMISION EUROPEA

01/01/2015 31/12/2018 273.499,99 €

Colaboración no desenvolvemento do proxecto 'Discovery of rare and ultra-rare frequency private population variation in cancer genes'


KING ABDULAZIZ UNIVERSITY (KAU)

01/01/2015 31/12/2016 19.882 €

Design and development of advanced NAnomedicines to overcome Biological BArriers and to treat severe diseases (NABBA)


COMISION EUROPEA

01/01/2015 31/12/2018 495.745,91 €

Pharmacological chaperones for genetic prion diseases (CHAPRION)


ERANET e-RARE 01/01/2015 31/12/2017 149.987,97 €

THE EFFECT OF AIP MUTATIONS ON THE APOPTOTIC RET PATHWAY IN PITUITARY ADENOMAS


MEDICAL RESEARCH COUNCIL (MRC)

01/01/2015 30/04/2018 175.848,36 €

A Novel HIV-1 Vaccine Targeting the 12 protease Cleavage Sites


UNIVERSITY OF MANITOBA

01/05/2015 30/04/2016 87.922,34 €

A EUropean study on effectiveness and sustainability of current Cardiac Rehabilitation programmes in the Elderly : EU-CaRE

González Juanatey, José Ramón

Unión Europea 01/05/2015 30/04/2019 553.855 €

Collaboration Agreement for the exection of the project: "Sequential combination of chemo-immunotherapy with trabectedin and functionalized immunomodulatory nanostructures to optimally target Tumor-Associated Macrophages in vivo"


Fondazione Humanitas per la Ricerca

15/05/2015 15/05/2018 59.950 €

PanCanRisk: Personalised bioinformatics for global cancer susceptibility identification and clinical management


COMISION EUROPEA

01/07/2015 30/06/2018 2.948.185 €

Role of p53 on hepatic steatosis and insulin sensitivity


European Foundation for the Study of Diabetes (EFSD)

01/07/2015 30/06/2018 30.000 €

Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST)


COMISION EUROPEA

01/09/2015 31/08/2020 399.000 €

57

Covariations between population neuronal activity and choice: a sensory or cognitive origin?

Pardo Vázquez, José Luis

HUMAN FRONTIER SCIENCE PROGRAM ORGANIZATION (HFSP)

01/10/2015 06/10/2016 5.939,92 €

"The Effect of AIP mutations on the apoptotic RET pathway in pituitary adenomas" MRC / MR/M018539/1 /010550 QM


QUEEN MARY UNIVERSITY OF LONDON

01/05/2015 30/04/2018 173.038,60 €

Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)


COMISION EUROPEA

29/11/2016 31/12/2021 551.375 €

The obesity paradox in multiple prevalent diseases: a translational approach.

González Juanatey, José Ramón.

INSTITUTO DE SALUD CARLOS III.

2014 2016 75.625 €




2014 2016 75.625 €




2014 2016 75.625 €




2014 2016 75.625 €

Adipoplast López Pérez, Miguel Antonio

Ministerio de Economía y Competitividad

2015 2016 45.000 €

Adipoplast Araujo Vilar, David

Ministerio de Economía y Competitividad

2015 2016 _

Estudio Del Papel De La Uroguanilina En El Metabolismo Cardiomiocitario.

Francisca Lago Paz y González Juanatey, José Ramón.

Research Foundation Eugenio Rodríguez Pascual

2015 2016 18.000 €

Convenio de colaboracion entre FPGMX, FRD y FMJJ. Estudios de Farmacogenómica, Búsqueda de neuromarcadores y la evaluación del uso de las tecnologías de secuenciación masiva en el diagnóstico genético del autismo


Fundación María José Jove

2016 2018 100.000 €

Descubrimiento y validación de marcadores farmacogenéticos de toxicidad para quimioterapia con fluoropirimidinas, oxaliplatino e irinotecan en cáncer colorrectal

Carracedo Álvarez

Gobierno de España - MINECO (ISCIII)

2017 2019 187.852,50 €

Terapia celular. - RETICS 2012 Labandeira García, José Luis


01/01/2013 31/12/2017 67.650 €

Construcción de un array de variación funcional en exomas de población española: Búsqueda de genes implicados en cáncer colorrectal y en respuesta al tratamiento quimioterápico

Jorge Amigo, Maria Torres, Ines Quintela, Beatriz Sobrino, Raquel Cruz, Catuxa Celeiro

FPGMX 01/01/2014 31/12/2016 238.975 €

58

Decodificando los priones: elucidación de la base estructural de la infectividad de proteínas.



01/01/2014 31/12/2016 133.100 €

El receptor de colágeno GPVI como nueva diana farmacológica anti-plaquetaria en infarto agudo de miocardio.



01/01/2014 31/12/2016 114.950 €

Mecanismos fisiológicos de recambio y proliferación, benigna y maligna, de las células foliculares tiroideas humanas.



01/01/2014 31/12/2016 242.000 €

Regulación de la producción de entrecruzamientos durante la recombinación mitótica.



01/01/2014 31/12/2016 181.500 €

ESTUDIO DEL PAPEL DE LOS TRANSCRITOS DE BSCL2 EN LA ADIPOGENESIS Y NEUROGENESIS

David Araujo Instituto de Salud Carlos III

01/01/2014 31/12/2016 68.365 €

Actividad endocrina de la grasa epicárdica como indicador en la insuficiencia cardiaca.

Eiras Penas, Sonia


01/01/2014 31/12/2016 67.760 €

Construcción de un array de variación funcional en exomas de población española: Búsqueda de genes implicados en cáncer colorrectal y en respuesta al tratamiento quimioterápico

Carracedo Álvarez

Gobierno de España - MINECO (ISCIII)

01/01/2014 31/12/2016 238.975 €

Nuevos abordajes para el diagnóstico, tratamiento y regeneración de la patología de la superficie ocular-SURFeye.



28/01/2014 31/12/2016 123.801 €

Convenio de colaboracion entre FPGMX, FRD y FMJJ. Estudio farmacogenéticode la respuesta al tratamiento del Trastorno de deficit de atencion e hiperactividad (TDAH) y el Trastorno obsesivo compulsivo (TOC)


Fundación María José Jove

02/05/2014 01/05/2016 100.000 €

Monitorización de la función cardíaca durante el tratamiento con agentes cardiotóxicos en la terapia antineoplásica

Raposeiras Roubin, Sergio/Ricardo Lage Fernández

Fundación Mutua Madrileña

01/10/2014 01/10/2017 36.000 €

Aplicación de la nanotecnología al desarrollo de vacunas para autoinmunidad. - RETOS



01/01/2015 31/12/2017 229.900 €

Aplicación de nuevos paradigmas en la farmacología molecular de los GPCRs a descubrimiento temprano de fármacos. - RETOS (Subproyecto coordinador).



01/01/2015 31/12/2017 121.000 €

59

Efectos biológicos de Ghrelin a nivel central sobre homeostasis energética y metabólica. - PROYECTOS I+D



01/01/2015 31/12/2017 375.100 €

Inferencia en los Modelos de Regresión Aditivos Estructurados (STAR) con Extensiones a Respuestas Multivariantes. Aplicaciones en Biomedicina. - RETOS

Cadarso Suárez, Carmen María


01/01/2015 31/12/2017 58.080 €

Nanomedicamentos altamente funcionales para la supresión de células iniciadores de glioblastoma. - RETOS

García Fuentes, Marcos


01/01/2015 31/12/2017 108.900 €

Papel de SUMO en la interacción virus-PI3K/AKT. PROYECTOS I+D

Rivas Vázquez, María Carmen


01/01/2015 31/12/2017 157.300 €

Papel en diabetes y cavernomas cerebrales de las quinasas GCKIII y proteínas asociadas. - RETOS

Zalvide Torrente, Juan Bautista


01/01/2015 31/12/2017 121.000 €

Plataforma de recursos biomoleculares e bioinformáticos, PRB2.



01/01/2015 31/12/2017 334.775,90 €

InveNNta-2 (Innovación en Nanomedicina: apoyo al empleo y al desarrollo socio-económico en el nuevo sistema productivo de la Euroregión).

José Castillo Sánchez, Fernando Domínguez, José Rivas Rey, Rafael López López.

Xunta de Galicia (Consellería de Economía, Emprego e Industria - Axencia Galega de Innovación (GAIN).

01/01/2015 31/10/2016 800.000 €

Bases fisiopatológicas del eje AGE-RAGE en el remodelado ventricular post-infarto y sus posibilidades como futura diana terapéutica

González Juanatey, José Ramón (García Seara Javier)


01/01/2015 31/12/2017 134.915 €

Historia natural, prevalencia y bases moleculares de la encefalopatía de Celia

David Araújo Vilar

Fundación Mutua Madrileña

01/09/2015 07/12/2018 130.000 €

Aplicación de la ultrasecuenciación de nueva generación para la caracterización taxonómica y análisis poblacional de un tripanosomátido emergente que infecta abejas y otros himenópteros en la Península Ibérica. - INIA

Maside Rodríguez, Julio Manuel


17/09/2015 16/09/2018 93.000 €

Validación de nuevas dianas terapéuticas y nuevos biomarcadores en enfermedad de Parkinson

Jose Luis Labandeira Garcia

ISCIII. Ciberned 01/10/2015 30/09/2017 240.000 €

60

Regulación Central en la Homeostasis Energéntica



03/11/2015 02/11/2019 40.000 €

AMPK hipotalámica y balance energético. - RETOS 2015

Miguel A. López Pérez


01/01/2016 31/12/2018 363.000 €

Metabolismo de las células tumorales y AMPK. Talón de Aquiles y nueva diana terapéutica en los astrocitomas cerebrales. - AES 2015



01/01/2016 31/12/2018 110.715 €

Papel de p53 y p63 hepáticos en la homeostasis metabólica. Implicaciones en desórdenes asociados a obesidad. - RETOS 2015

Rubén Nogueiras


01/01/2016 31/12/2018 242.000 €

Pit-1, vitamina D y estroma en cáncer de mama. - RETOS 2015



01/01/2016 31/12/2018 133.100 €

Sistema renina-angiotensina cerebral en neuroinflamación y degeneración dopaminérgica. Más allá del eje AII/AT1/NADPH-OXIDASA. - EXCELENCIA 2015

José Luis Labandeira García


01/01/2016 31/12/2018 296.450 €

Prevencion, detección precoz, tratamiento y rehabilitación de las patologías oculares (Oftared)

Francisco Gonzalez Garcia

RETICS, ISCIII 01/01/2016 31/12/2020 25.476 €

Coste-efectividad y coste utilidad de una estrategia de transfusión de hematíes " "liberal" vs. otra " restrictiva" en pacientes con infarto

Abu Assi, Emad (Jose Ramón González Juanatey)


01/01/2016 31/12/2018 38.115 €

Estudio del papel de la relaxina sobre la regulación del metabolismo y autofagia cardiomiocitarios. Implicaciones en la fisiopatología de las enfermedades cardiometabólicas.

Francisca Lago Paz.


01/01/2016 31/12/2018 96.800 €

Desarrollo de tratamientos personalizados para el glaucoma. Énfasis en poblaciones infantiles y de edad avanzada. GLAUKUS. RETOS-COLABORACIÓN 2016



07/03/2016 31/12/2018 140.140 €

Soluciones innovadoras para el tratamiento del ojo seco combinado con dolor ocular - SEKEYE. RETOS-COLABORACIÓN 2016



07/03/2016 31/12/2018 209.160 €

61

Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y radioterapéuticos. Identificación de nuevos antitumorales individualizados


AECC 22/09/2016 31/12/2022 1.200.000 €

Papel de p63 hepático en el control del metabolismo de glucosa y señalización de insulina


FUNDACION ASTRAZENECA

26/10/2016 25/10/2017 20.000 €

Análisis de la acción conjunta de la familia de proteínas Ten-elevaen translocation y las proteínas con bromo dominios durante la generación de células pluripotentes inducida. EXCELENCIA 2016



30/12/2016 29/12/2019 193.600 €

Efecto sobre el metabolismo energético y termogénesis de SIRT1 y SIRT3 en BAT en estados de resistencia a la insulina inducida por HFD y en el envejecimiento. RETOS 2016



30/12/2016 29/12/2020 133.100 €

Estudio bioquímico del procesado de los intermediarios de la replicación y la recombinación del ADN. EXCELENCIA 2016



30/12/2016 29/12/2019 181.500 €

Impacto de la obesidad en la reactividad de las plaquetas en la enfermedad coronaria: análisis bioquímico y funcional. RETOS 2016



30/12/2016 29/12/2019 140.360 €

Implicaciones fisiopatológicas de los mecanismos de recambio y proliferación, benigna y maligna, de las células foliculares tiroideas humanas y de glándulas endocrinas. RETOS 2016



30/12/2016 29/12/2019 254.100 €

Nueva estrategia multi-etapa para la liberación oral de biomacromoléculas terapéuticas. RETOS 2016



30/12/2016 29/12/2019 96.800 €

Consolidación e estruturación. (GRC) GI-1736 Medicina Xenómica GMX.


Conselleria de Cultura, Educacion e Ordenacion Universitaria

01/01/2013 31/12/2016 370.000 €

Consolidación e estruturación. (GRC) GI-1233 Grupo de investigacións biomédicas GIB.



01/01/2013 31/12/2016 370.000 €

62

Matrices bioactivas para la supresión de células iniciadoras de glioma. (EMERXENTES)



08/08/2013 08/08/2016 97.000 €

Consolidación e estruturación. GPC GI-1698 Patoloxía Molecular

Araújo Vilar, David


01/01/2014 30/11/2016 70.000 €

Consolidación e estruturación. GRC GI-1337 Grupo de Neurobioloxia Molecular e Celular da Enfermidade de Parkinson

Labandeira García, José Luis


01/01/2014 30/11/2017 320.000 €

Consolidación e estruturación. GRC GI-1685 Bioloxía de membranas e mecanismos de transducción de sinais en farmacoloxía aplicada.



01/01/2014 30/11/2017 400.000 €

Desarrollo inicial de nuevos derivados de curcumina con potencial aplicación en el tratamiento de enfermedades neurodegenerativas. EMERXENTES

Viña Castelao, María Dolores

Conselleria De Cultura, Educacion E Ordenacion Universitaria

14/05/2014 30/11/2016 93.000 €

unidad mixta usc-esteve para descubrimiento temprano de fármacos con estándares de innovación abierta.


Axencia Galega De Innovacion

18/07/2014 31/10/2017 803.598,85 €




01/01/2016 30/11/2020 115.000 €

Consolidación e estruturación -MODALIDADE D 2016



01/01/2016 30/11/2019 90.000 €




01/01/2016 30/11/2019 90.000 €




05/11/2016 30/11/2020 200.000 €




05/11/2016 30/11/2020 200.000 €

TOTAL 27.727.371,08 €

63


Amount €

Obesidad Diéguez González, Carlos

NOVO NORDISK PHARMA, S.A.

11/04/2014 31/12/2016 9.000

Síntesis de una librería de compuestos por métodos enzimáticos.


PLASMIA BIOTECH, S.L.

15/04/2014 14/04/2019 3.500

Unidad mixta USC-ESTEVE para descubrimiento temprano de fármacos con estándares de innovación abierta


LABORATORIOS DEL DR. ESTEVE, S.A.

18/07/2014 31/10/2017 1536667

Puesta a punto y desarrollo de un ensayo radiactivo para la cuantificación de la actividad de las dianas epigenéticas de interés y cribado de moléculas en dichas dianas.


ORYZON GENOMICS, S.A.

23/01/2015 22/01/2017 8.000

Asesoramento científico e técnico naqueles proxectos relacionados con aplicacións biomédicas das nanopartículas, nanofibras e AQCs nos que Nanogap estea involucrado

Domínguez Puente, Fernando

NANOGAP SUB-NM-POWDER, S.A.

28/02/2015 27/02/2016 12.000

Investigación, desarrollo e innovación en nuevos alimentos multifuncionales para síndrome metabólico (METASIN) - Programa CIEN 2015

Costoya Puente, José Antonio

FEIRACO LACTEOS, S.L.U.

05/05/2015 31/12/2018 18.858

Advisory services in the field of Heptocellular Carcinoma through the appointment of Dr Jose Antonio Costoya-Puente as a member of Midatech Oncology Advisory Board (OAB)


MIDATECH PHARMA PLC

19/05/2015 18/05/2016 2.500

Estudio a nivel nacional del fármaco liraglutide

Cadarso Suárez, Carmen María

NOVO NORDISK PHARMA, S.A.

07/07/2015 07/07/2016 10.285

Services for the Study "international multi-centre clinical trials under Sponsor´s Protocol 1373.3 to clinicallly evaluate Study Drug"


ABF PHARMACEUTICAL SERVICES GMBH

29/10/2015 31/12/2017 0

Puesta a punto y desarrollo de ensayos farmacológicos y cribado de moléculas en dichos ensayos


PALOBIOFARMA, S.L.

18/11/2015 31/12/2016 50.000

Puesta a punto y desarrollo de ensayos farmacológicos y cribado de moléculas en dichos ensayos


ONCOSTELLAE, S.L.

23/11/2015 30/06/2016 13.700

Research lines in Thyroid deseases Álvarez Villamarín, M. Clara

ENDOSCIENCE SERVICE GMBH

23/11/2015 22/11/2020 37.500

Obtaining 60 hamster scraie 263k infected brains

Jesús Rodríguez Requena

MICROBAC LABORATORIES, INC.

14/01/2016 30/07/2016 18.675,54 €

64



ONCOSTELLAE, S.L.

20/01/2016 30/11/2018 32.000,00



GALCHIMIA, S.A.

27/01/2016 30/11/2018 22.800,00

Consultancy on technical expertise on the pharmaceutical development of EG 1964

María José Alonso Fernández

EDGE THERAPEUTICS, INC.

06/03/2016 07/03/2016 3.609,08 €

Test Biologically active COMPOUNDS in protein plasma, protein binding, phase I microsomal metabolism and plasma stability assays


ALMIRALL, S.A. 28/06/2016 30/06/2017 35.000,00

Convenio de Colaboración para el estudio sobre el desarrollo de nuevos sistemas de vehiculización y nuevos biomarcadores de personalización del tratamiento del cáncer


SUNROCK BIOPHARMA, S.L.

01/07/2016 31/12/2018 26.250,00

Collaborative research agreement in the field of potential aplication of nanotechnologies in specific drug delivery



01/12/2016 01/12/2017 185.680,00



01/01/2016 31/12/2020 15.486,91


CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB

01/01/2016 31/12/2020 6.249,79


FUNDACION PARA LA INVESTIGACION HOSPITAL GREGORIO MARAÑON

01/01/2016 31/12/2020 9.918,44


CENTER FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY

01/01/2016 31/12/2020 2.763,98

65


LABORATORIO DE ANALISIS CLINICAS DR. JOAQUIM CHAVES

01/01/2016 31/12/2020 1.404,25


FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

01/01/2016 31/12/2020 4.922,12


CONSORCIO DEL HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA

01/01/2016 31/12/2020 17.805,75


UNIVERSIDAD DE OVIEDO

01/01/2016 31/12/2020 9.159,58


INSTITUT D'INVESTIGACIONS BIOMEDIQUES AGUSTI PI I SUNYER (IDIBAPS)

01/01/2016 31/12/2020 5.331,69


FUNDACION PARA EL FOMENTO DE LA INVESTIGACION SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA

01/01/2016 31/12/2020 550,28


IFAPA ALAMEDA DEL OBISPO

01/01/2016 31/12/2020 3.298,98


VALL D'HEBRON INSTITUTE OF ONCOLOGY - VHIO

01/01/2016 31/12/2020 4.944,26


FUNDACION PUBLICA ANDALUZA PARA LA INVESTIGACION DE MALAGA EN BIOMEDICINA Y SALUD (FIMABIS)

01/01/2016 31/12/2020 15.019,35

66



01/01/2016 31/12/2020 367,72



01/01/2016 31/12/2020 38.933,29


FUNDACION INSTITUTO DE INVESTIGACION SANITARIA ARAGON

01/01/2016 31/12/2020 11.683,12


INSTITUT DE RECERCA BIOMEDICA DE LLEIDA

01/01/2016 31/12/2020 1.659,06



01/01/2016 31/12/2020 3.007,62


MAKING GENETICS, S.L.

01/01/2016 31/12/2020 1.214,78


INSTITUTO DE MEDICINA PREDICTIVA Y PERSONALIZADA DEL CANCER

01/01/2016 31/12/2020 2.522,41


INSTITUTO DE INVESTIGACION MARQUES DE VALDECILLA - IDIVAL

01/01/2016 31/12/2020 1.261,00


MG NUTRICION 3G

01/01/2016 31/12/2020 2.420,58


UNIVERSIDAD DE SEVILLA

01/01/2016 31/12/2020 5.769,62


NORWEGIAN INSTITUTE OF PUBLIC HEALTH (NIPH)

01/01/2016 31/12/2020 784,94


UNIVERSITAT JAUME I

01/01/2016 31/12/2020 2.972,75


CLINICA UNIVERSIDAD DE NAVARRA

01/01/2016 31/12/2020 2.776,68



01/01/2016 31/12/2020 10.507,09

67



01/01/2016 31/12/2020 17.491,12


INSTITUTO DE MEDICINA ONCOLOGICA Y MOLECULAR DE ASTURIAS

01/01/2016 31/12/2020 420,24


FUNDACIO ACE. INSTITUT CATALA DE NEUROCIENCIAS

01/01/2016 31/12/2020 939,95


HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS

01/01/2016 31/12/2020 8.612,74


INSTITUT D'INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL

01/01/2016 31/12/2020 2.522,41


UNIVERSIDAD AUTONOMA DE CHILE

01/01/2016 31/12/2020 672,22


FUNDACION INVESTIGACION BIOMEDICA HOSPITAL CLINICO SAN CARLOS

01/01/2016 31/12/2020 1.314,97



01/01/2016 31/12/2020 57.182,05


REFERENCE LABORATORY

01/01/2016 31/12/2020 2.031,26


IGENOMIX S.L. 01/01/2016 31/12/2020 1.378,04


BANCO NACIONAL DE ADN CARLOS III

01/01/2016 31/12/2020 1.018,43


INSTITUTO CAJAL - CSIC

01/01/2016 31/12/2020 2.351,62



01/01/2016 31/12/2020 21.416,34


MAX PLANCK INSTITUTE FOR PLANT BREEDING RESEARCH

01/01/2016 31/12/2020 12.600,00

68


UNIVERSIDAD POLITECNICA DE VALENCIA

01/01/2016 31/12/2020 735,42

Plataforma: Unidade de Screening Loza García, María Isabel

LILLY, S.A. 01/01/2016 31/12/2020 21.739,00


ELI LILLY AND COMPANY

01/01/2016 31/12/2020 87.655,00


UNIVERSIDAD DE BURGOS

01/01/2016 31/12/2020 1.440,00


LANDSTEINER GENMED, S.L.

01/01/2016 31/12/2020 19.498,33


UNILEVER CENTRE FOR MOLECULAR SCIENCES INFORMATICS

01/01/2016 31/12/2020 2.240,00


UNIVERSIDADE DE VIGO

01/01/2016 31/12/2020 381,50


INSTITUTO DE SINTESIS QUIMICA Y CATALISIS HOMOGENEA - CSIC

01/01/2016 31/12/2020 1.800,00


UNIVERSIDAD DE CASTILLA LA MANCHA

01/01/2016 31/12/2020 540,00

Plataforma: Servizo de Secuenciación



01/01/2016 31/12/2020 129,02




01/01/2016 31/12/2020 15.590,50



FUNDACION BIOMEDICA GALICIA SUR

01/01/2016 31/12/2020 3.813,75



NANOIMMUNOTECH,S.L.

01/01/2016 31/12/2020 2.563,19

Servizo de Farmacoxenómica (FARMAXEN)


LILLY, S.A. 01/01/2016 31/12/2020 32.140,00

TOTAL 2.528.977,76 €

69


Amount €

Estudo da xenómica da leucemia linfocítica crónica (proxecto LLC)



10/05/2010 31/12/2016 62.097,00 €

Proyecto de investigación: Interacción de ADN con complejos organometálicos de Ru(II) y clústeres cuánticos atómicos (AQC's)

Domínguez Puente, Fernando

Obra Social 'la Caixa'

01/01/2013 31/12/2016 262.890,00 €

Convenio para fomentar a actividade investigadora do persoal investigador finalista nas convocatorias de axudas do ERC no marco da H2020


AXENCIA GALEGA DE INNOVACION

01/01/2015 30/04/2016 50.000,00 €

Convenio para fomentar a actividade investigadora do persoal investigador finalista nas convocatorias de axudas do ERC no marco de H2020


AXENCIA GALEGA DE INNOVACION

01/01/2015 30/04/2016 50.000,00 €

Convenio de Colaboración para complementar as axudas ao personal investigador principal dos Programas Starting Grants, Consolidator Grants e Advanced Grants do Consello Europeo de Investigación



01/01/2015 15/12/2016 99.619,49 €

Convenio de Colaboración para complementar as axudas ao personal investigador principal dos Programas Starting Grants, Consolidator Grants e Advanced Grants do Consello Europeo de Investigación



01/01/2015 15/12/2016 99.712,60 €

Colaboración no desenvolvemento do proxecto 'Discovery of rare and ultra-rare frequency private population variation in cancer genes'



01/01/2015 31/12/2016 19.882,00 €

La enzima AMPK, un nexo de unión entre metabolismo y cáncer. Una nueva estrategia terapéutica en los glioblastomas cerebrales.


FUNDACION RAMON ARECES

07/04/2015 06/04/2018 99.000,00 €

Role of p53 on hepatic steatosis and insulin sensitivity


European Foundation for the Study of Diabetes (EFSD)

01/07/2015 30/06/2018 30.000,00 €

70

Contrato de servicio para "Genotipado masivo en plataforma de Alto Rendimiento para el Análisis Genómico en muestras para Estudio de Enfermedades Respiratorias" (exp. 01/2015)



10/07/2015 09/07/2017 77.317,34 €

Radiogenómica: evaluación de variantes raras asociadas a toxicidad radioinducida e identificación de variantes causales mediante Fine-mapping.



15/01/2016 03/02/2016 74.793,89 €

Determinación de biomarcadores: Análisis muestras aspirado sangre, pezón y orina



01/03/2016 31/12/2016 31.921,00 €

Determinantes clínicos y neurobiológicos de segundos episodios de esquizofrenia. Estudio longitudinal de primeros episodios psicóticos.



22/03/2016 10/06/2016 49.958,32 €




18/04/2016 17/07/2016 12.089,92 €




01/05/2016 30/04/2017 3.200,00 €


Pérez Fernández, Román


01/05/2016 31/05/2017 18.700,00 €

servicio de xenotipado Carracedo Álvarez, Ángel María

UNIVERSITAT POMPEU FABRA

19/05/2016 18/05/2017 25.203,56 €

Construcción de un array de variación funcional en exornas de la población española: búsqueda de genes implicados en el cáncer colorrectal y en respuesta al tratamiento quimioteráptico (PI13/01136)



28/09/2016 27/01/2017 114.653,70 €

TOTAL 1.162.338,82 €

71

Title IP Call/Entity Start date End date

Agreement to carry out the research conducting to expand the USC's chemical library


Peakdale Molecular Limited, Ltd

07/12/2012 06/12/2017

Services for the Study "international multi-centre clinical trials under Sponsor´s Protocol 1373.3 to clinicallly evaluate Study Drug"


ABF PHARMACEUTICAL SERVICES GMBH

29/10/2015 31/12/2017


IDP DISCOVERY PHARMA, S.L.

08/03/2016 07/03/2026

Confidencial Disclosure Agreement: 'Purpose of determining interest in and pursuing business discussions relating to GSK site(s)'


GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO, S.L.

05/04/2016 04/04/2021


THE UNIVERSITY OF NOTTINGHAM

05/04/2016 04/04/2021

Acuerdo de Confidencialidad Diéguez González, Carlos

BIOMEDICA MOLECULAR MEDICINE, S.L.

28/04/2016 27/04/2018

Protocolos experimentales detallados para ensayar compuestos con actividad farmacológica en ensayos de unicón a proteína plasmática y estabilidad en microsomas


ALMIRALL PRODESFARMA, S.A.

18/05/2016 17/05/2026


SAGETIS BIOTECH, S.L.

26/05/2016 25/05/2019

Acordo de Confidencialidade 'Spanish exome array content'


AFFYMETRIX UK LTD 14/06/2016 13/06/2017

Acuerdo de confidencialidad Alonso Fernández, María José

ALMIRALL, S.A. 29/07/2016 28/07/2017

Mutual Confidential Disclosure Agreement



10/08/2016 09/08/2017

Mutual Confidential disclosure agreement


MERCK SHARP & DOHME CORP.

24/08/2016 23/08/2017

Non Disclosure agreement Alonso Fernández, María José

COLUMBUS VENTURE PARTNERS SGEIC, S.A.

06/10/2016 07/10/2021


PANGAEA BIOTECH, S.L.

18/11/2016 17/11/2019

Acordo de Confidencialidade Loza García, María Isabel

BIOSTATECH, ADVICE,TRAINING & INNOVATION IN BIOSTATISTICS, S.L.

15/12/2016 14/12/2036

Non Disclosure Agreement 'development and production of mAbs for their use in testing innovative delivery technology'


PX'THERAPEUTICS SAS

19/12/2016 18/12/2018

72

Acuerdo de Mútuo de Confidencialidad


INDUSTRIAL FARMACEUTICA CANTABRIA, S.A.

29/12/2016 28/12/2026

Material Transfer Agreement (Order 256926)

Rubén Nogueiras ADDGENE 07/03/2016 06/03/2021

Actividades de difusión de calidad y realización de actuaciones de evaluación competencia de ENAC

González García, Francisco

Entidade Nacional de Acreditación

12/11/2012 11/12/2017

Report of the Infrafrontier Work Package 5 with explicit construction plans of different research facilities


Helmholtz Zentrum München

19/11/2012 18/11/2017

Colaboración no desenvolvemento do proxecto 'Discovery of rare and ultra-rare frequency Saudi population variation in colorrectal cancer genes'



01/09/2013 31/12/2016

Material Transfer Agreement: 'Compound UB, with putative SEH inhibitory activity'



01/01/2016 31/12/2020




18/04/2016 17/07/2016

Farmacocinética, biodistribución y respuesta terapéutica de nanocápsulas / nanoemulsiones funcionalizadas y cargadas con docetaxel en un modelo murino de carcinoma ortópico de pulmón


UNIVERSIDAD DE NAVARRA

22/06/2016 30/10/2016

73

5. HUMAN RESOURCES

c. New Researchers/students

Name Surname Group Start date Finish date Kind

Lucía Bada Díaz Cardiovascular Pharmacology

17/06/2016 17/06/2019 PhD Student

Miguel Ángel Chenlo Miranda

Neoplasia and Endocrine

Differenciation

10/03/2016 10/03/2019 PhD Student

Patricia Cordeiro González

Genomic Medicine

03/03/2016 03/03/2017 PhD Student

Juan Cuñarro Gómez

Functional Obesomics

03/10/2016 30/09/2019 PhD Student

Ricardo Daniel Estévez López MOL

12/12/2016 01/06/2017 PhD Student

Iago Fernández Mariño

Nanobiopharmaceiticals

22/09/2016 01/09/2018 PhD Student

Antía Fernández Pombo

UETeM 31/10/2016 31/10/2019 PhD Student

María García Garrote Parkinson Disease

20/01/2016 04/01/2019 PhD Student

Sara González Carro Oncology research

09/12/2016 30/06/2018 PhD Student

Patricia González Sáenz

Molecular Metabolism

27/04/2016 27/04/2020 PhD Student

Edward Milbank NeurObesity 01/06/2016 01/10/2016 PhD Student

Hanaa Moussa Cardiovascular Pharmacology

06/05/2016 01/07/2017 PhD Student

María Núñez Barrachina

Platelet Proteomics

11/01/2016 11/01/2019 PhD Student

Diego Pan Delgado Nanobiopharmaceiticals

22/09/2016 31/07/2018 PhD Student

José Ángel Pardavila Paz Vascular Biology

04/04/2016 01/04/2019 PhD Student

Iván Pensado Méndez

Neuroendocrinology

07/03/2016 07/03/2019 PhD Student

Ghizlane Salhi Oncology research

11/01/2016 01/08/2016 PhD Student

Giulia Salluce Visual Science 07/07/2016 07/07/2019 PhD Student

Miriam Sartages García

Vascular Biology

06/10/2016 01/09/2019 PhD Student

Yara Souto Becerra Vascular Biology

04/05/2016 04/05/2019 PhD Student

Bhanu Teja Surikutchi Nanobiopharmaceiticals

17/10/2016 30/09/2018 PhD Student

Miguel Ángel Fidalgo Pérez Cardiovascular Pharmacology

01/04/2016 Postdoctoral researcher

74

Francesco Mainini Nanobiopharmaceiticals

07/12/2016 31/12/2018 Postdoctoral researcher

Henrique Rodrígues Marcelino

Nanobiopharmaceiticals


Eleni Samaridou Nanobiopharmaceiticals


Rodolfo De Diego Garrido

Biofarma 01/03/2016 27/04/2016 Visiting

researcher

Saioa Elezgarai Rodríguez

Biofarma 11/01/2016 19/01/2016 Visiting

researcher Alicia Fernández

Fuentes CiClON

13/07/2016 31/07/2016 Visiting researcher

Sabela Fernández Vila Biofarma


Sogol Gachkar NeurObesity


Juan F. López Giménez Biofarma


Jorge Lozano Juste Biofarma


Eleanor Mckay Functional Obesomics


Alba Miguéns Gómez

MOL 15/07/2016 29/07/2016 Visiting

researcher Gabriel Porcel

Fernández Molecular

Neuropathology


María Roel Sánchez CiClON


Deria Sena Yaman UETeM


Alba Torán Vilarrubias

MOL 15/07/2016 29/07/2016 Visiting

researcher Fernando Torres Andón Nanobiopharm

aceiticals 07/01/2016 28/02/2016 Visiting

researcher Yaiza Casariego

Pedreira Biofarma

12/09/2016 24/12/2016 Technician

Noelia Duarte Montaña

Cardiovascular Area

18/01/2016 30/09/2017 Technician

Gloria Martínez Río CiMUS 12/07/2016 16/12/2016 Technician

Aldara Viaño Castañeda

DNA Repair and Genomic

Integrity

11/01/2016 16/05/2016 Technician

Iaroslava Dolisnea Molecular Neuropatholog

y

20/10/2016 31/12/2017 TFG

Tania Fernández Rodríguez

Cell Signaling and Stress

17/10/2016 30/06/2017 TFG

Andrea Fórneas Sangil Biofarma 04/10/2016 30/07/2017 TFG

Vera García Outeiral Vascular Biology

15/11/2016 30/06/2017 TFG

75

Beatriz González Fernández

Neuroendocrinology

07/06/2016 31/07/2017 TFG

Rocío Lorenzo López Neuroendocrinology

24/05/2016 31/07/2016 TFG

Lucía Mayán Santos Cardiovascular Pharmacology

03/02/2016 30/07/2016 TFG

Sara Nieves Mallo Biofarma 27/09/2016 30/07/2017 TFG

Cristina Pardo Primoy Molecular Neuropatholog

y

05/02/2016 31/07/2017 TFG

Silvia Pérez Castro Virus & Cancer 04/05/2016 31/07/2016 TFG

Alejandro Rego Calvo Molecular Metabolism

05/12/2016 30/06/2017 TFG

Paula Sánchez Mandayo


Integrity

22/06/2016 31/07/2017 TFG

Rocío Seoane Abelenda

Virus & Cancer 12/09/2016 01/07/2017 TFG

Alex Tuñas Corzón Genomic Medicine

29/02/2016 31/07/2016 TFG

Sandra Viz Lasheras Neuroendocrinology

04/10/2016 31/07/2017 TFG

Paula Alonso Batán Biofarma 16/09/2016 31/07/2017 TFM

Cristina Ameneiro Quiñoy

Vascular Biology

03/11/2016 31/07/2017 TFM

Azucena Calderón Rangel

Biofarma 05/10/2016 30/06/2017 TFM

Raquel Carreira Rodríguez


Integrity

16/09/2016 31/08/2017 TFM

Beatriz Crego Varela Neuroendocrinology

04/10/2016 31/07/2017 TFM

Tania Patricia Días Fernándes

CiClON 26/09/2016 30/06/2017 TFM

Adriana Escudero Pérez

Vascular Biology

26/09/2016 30/06/2017 TFM

Ricardo Daniel Estévez López MOL

11/04/2016 15/07/2016 TFM

Tomás Lama Díaz DNA Repair and Genomic

Integrity

19/07/2016 31/07/2017 TFM

Anael López Novo MOL 16/03/2016 31/07/2016 TFM

Ana María Pastoriza Mourelle

Biofarma 11/01/2016 31/07/2016 TFM

David Sanfiz Alonso Biofarma 25/10/2016 31/07/2017 TFM

Moises Shabot Slydlo Genomic Medicine

11/01/2016 01/08/2016 TFM

Laura Isabel Sinisterra Loaiza

Platelet Proteomics

29/02/2016 22/07/2016 TFM

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Lydia Veiras Grela Biofarma 18/03/2016 17/06/2016 TFM

Santiago Vidal Freire Virus & Cancer 01/12/2016 30/09/2017 TFM

Marta Vizoso González

Genomic Medicine

27/01/2016 25/07/2016 TFM

d. Visiting researchers.

At CiMUS

Name Institution Country Start date Finish date Group

Purificación Ordás Fernández

Instituto de Neurociencias de Alicante (UMH-CSIC).

Spain 10/10/2016 23/12/2016 Neuroendocrinology

Sandra Larissa Elena Blümich

Universidad de Leipzig Germany 30/05/2016 29/07/2016 Biofarma

Juan López Gimenez

CSIC Spain 01/09/2016 31/07/2018 Biofarma

Zohreh Saltanatpouri

Tehran University of Medical Sciences

Iran 05/12/2016 Now CiClOn

Sogol Gachkar Center of Brain Behavior and Metabolism (CBBM), University of Luebeck

Germany 02/05/2016 31/07/2016 NeurObesity

Eleanor Mckay Oxford University UK 25/10/2016 16/12/2016 Functional Obesomics

Rene Hernández Bautista

CONACYT México 01/07/2015 30/06/2017 Molecular metabolism

Tomas Kneib Universidad de Goettinge

Germany 04/04/2016 08/04/2016 Biostatistics

Nadja Klein Universidad de Goettinge


Tomas Kneib Universidad de Goettinge


Outgoing from CiMUS

Name Institution City, Country Start date Finish date CIMUS group

Ahmed El Motiam

Heinrich Pette Institut, Hamburg

Germany 19/10/2016 29/10/2016 Virus & Cancer

Sara Caetano Cordeiro

Instituto de Investigación en Biomedicina de Bellinzona

Switzerland 4 months 2016 Nanobiopharmaceuticals

Adriana Martínez Ledo

Harvard Paulson School of Engineering and Applied Sciences

USA 6 months 2016 Nanobiopharmaceuticals

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Vanesa Hurtado Nieves

Instituto Federal de Tecnología de Zurich (ETH Zürich).

Switzerland 25/03/2016 03/08/2016 DNA Repair & Genome Integrity

Miguel González Blanco



Francisco Javier Aguado Domínguez



Carmen Cadarso Universidad de Porto Portugal 09/05/2016 13/05/2016 Biostatistics

Carmen Cadarso Universidade de Coimbra

Portugal 21/09/2016 26/09/2016 Biostatistics

Carmen Cadarso Universidad Goettingen Germany 15/12/2016 20/12/2016 Biostatistics

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6. EDUCATION AND TRAINING

a. Thesis

Name Title Date Directors

Carmen Teijeiro Valiño

Nanocápsulas multifuncionales para la liberación selectiva de fármacos antitumorales

08/01/2016 María José Alonso, Noemi Csaba

Ana Borrajo Lopez

Mecanismos de Activación Microglial en Degeneración Dopaminérgica: Papel del eje Angiotensina/AT1/ Rho Quinasa.

15/01/2016 Jose L. Labandeira y Ana I. Rodriguez-Perez

Javier Munín Doce

Síntesis de derivados de ftalazina y estudio de su potencial actividad terapéutica

22/01/2016 Mª Dolores Viña Castelao, Eugenio Uriarte Villares, Elías Quezada González

Sanz Álvarez, Eva María

Acciones de la hormona de crecimiento sobre tejido óseo

25/01/2016 Jesús Devesa Múgica, José Antonio Costoya Puente

Mónica López Ratón

Optimal cutoff points for classification in diagnostic studies: new contributions and software development.

25/01/2016 Carmen Cadarso Suárez, Elisa M. Molanes López

Morey Villar, Marcos

APLICACIÓN DE LAS NUEVAS TECNOLOGÍAS DE SECUENCIACIÓN MASIVA DE ADN AL DIAGNÓSTICO GENÉTICO

25/01/2016 Cocho de Juan, Jose Angel, Fernández Marmiesse, Ana, DOMINGUEZ PUENTE, FERNANDO

María Aurora Baluja González

Estudio de polimorfismos genéticos como marcadores pronósticos en la sepsis

28/01/2016 Julian Alvarez Escudero, Ángel Carracedo Alvarez

Andrés Ordóñez Ugalde

Caracterización Clínico-Molecular e Investigación de Nuevas Herramientas de Diagnóstico Genético de la Paraparesia Espástica Hereditaria en la Población Española

29/01/2016 Ángel Carracedo Álvarez y María Jesús Sobrido

Javier Rodríguez Carracedo

Aspectos estructurales y cinéticos de la interacción ligando-receptor relevantes en la farmacología de la esquizofrenia.

01/02/2016 María de los Ángeles Castro Pérez, María Isabel Loza García

Sayagues Moreira, Laura

SÍNDROME CORONARIO AGUDO ACOMPAÑADO DE INSUFICIENCIA CARDIACA AGUDA: PÉRFIL CLÍNICO, PRONÓSTICO Y PAPEL DE LA REVASCULARIZACIÓN

03/02/2016 GONZÁLEZ JUANATEY, JOSÉ RAMÓN, García Acuña, Jose María, PEÑA GIL, CARLOS

Cristina Val García

Estrategias multicomponente en el descubrimiento de derivados Heterocíclicos Antagonistas de los receptores de Adenosina/Inhibidores de Fosfodiesterasas.

04/02/2016 Mª Isabel Loza García y Eddy Sotelo

Montserrat Santori Gómez

Estudio del componente genético de la muerte súbita infantil inexplicada

04/02/2016 Ángel Carracedo Álvarez, María Brión Martínez

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Noelia Martinez Sanchez

REGULACIÓN CENTRAL DEL BALANCE ENERGÉTICO POR HORMONAS TIROIDEAS

05/02/2016 López Pérez, Miguel Antonio

Sonia Lage Abad Estudio de la influencia de la reelina sobre receptores acoplados a proteínas G relacionadas con la farmacología de la esquizofrenia.

05/02/2016 Mª Isabel Loza García y Jose Manuel Brea Floriani.

Danel Rey González

Inferring population substructure using Y chromosome haplogroups and exome data

05/02/2016 Ángel Carracedo Álvarez y Raquel Cruz Guerrero

María Pazos Pata Cartografiado y modelización de las poblaciones naturales de semilla de mejillón en la costa gallega.

10/02/2016 Carmen Cadarso Suárez y Vicente Lustres.

Goretti Durán Piñeiro

Estudio farmacogenético de variantes polimórficas en genes reparadores del ADN y otros marcadores de resistencia en pacientes con cáncer de cabeza y cuello

10/02/2016 Ángel Carracedo Álvarez, María Jesús Lamas Díaz y Rafael López López

Sandra Filippini Nuevas tecnologías de secuenciación para el diagnóstico del lsíndrome de cáncer de mama y ovario hereditario

11/02/2016 Ángel Carracedo Alvarez, Ana Paula Vega Gliemmo

José Luis Abal Fabeiro

Análise dos padróns de diversidade xenética e epidemioloxía das especies e variedades de Cryptosporidium que parasitan humanos mediante o desenrolo dun protocolo multilocus de tipado xenético de alto rendemento

11/02/2016 Xulio Maside Rodríguez e Carolina Bartolomé Husson

Lorena Salgueiro Ferreño

Dissecting the contribution of Mad2 to oncogenic transformation in cells lacking p107 and p130

01/03/2016 Anxo Vidal, Carmen Carneiro

Mónica Imbernón Piedra

EFECTOS CENTARLES DE MCH SOBRE EL METABOLISMO PERIFÉRICO

18/03/2016 Nogueiras Pozo, Ruben

Niu Zhigao Diseño racional de nanovehículos para a administración oral de péptidos

03/05/2016 María José Alonso, Manuel Santander

Abumuaileq, Rami Riziq Yousef

RISK ASSESSMENT IN CONTEMPORARY OUTPATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION RECENTLY ON VITAMIN K ANTAGONISTS

18/05/2016 GONZÁLEZ JUANATEY, JOSÉ RAMÓN

Lungile Thwala Nanocápsulas de protamina para la liberación oral de péptidos

27/05/2016 María José Alonso,, Veronique Preat, Noemi Csaba

Montes Lourido, Maria del Pilar

EFECTO DUN ESTÍMULO POTENCIADOR NA ACTIVIDADE NEURONAL DA CORTEZA MOTORA, PUTAMEN E AMÍGDALA

10/06/2016 Gonzalez Garcia, Francisco, Señarís Rodríguez, Rosa María

Rodríguez Mañero, Moisés

CONTEMPORAY VIEW OF ATRIAL FIBRILLATION; BEYOND THE EUROPEAN GUIDELINESS FOR THE MANAGEMENT OF PATIENTS WITH ATRIAL FIBRILLATION

27/06/2016 GONZÁLEZ JUANATEY, JOSÉ RAMÓN, Martínez Sande, José Luis

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Hamed Mohamed Elhady Mosa Arisha, Ahmed

METABOLISMO LIPÍDICO HIPOTALÁMICO Y CONTROL DE LA INGESTA

29/07/2016 López Pérez, Miguel Antonio

Vélez Viéitez, Paula

Identificación de nuevos biomarcadores y dianas farmacológicas anti-plaquetarias en infarto agudo de miocardio

19/09/2016 Ángel García Alonso, José María García Acuña

Rocío Ailim de la Fuente González

Estudio del impacto de la dimerización y de variantes polimórficas en la farmacología y función de receptores acoplados a proteínas G (GPCRs) relevantes en la esquizofrenia.

14/10/2016 María de los Ángeles Castro Pérez, María Isabel Loza García

Inés Quintela García

Bases xenéticas da discapacidade intelectual e dos trastornos do espectro autista: aplicación das novas tecnoloxías á análise de variantes de número de copias (CNVs)

08/11/2016 CARRACEDO ALVAREZ, ANGEL MARIA BARROS ANGUEIRA, FRANCISCO Eiris Puñal, Jesús Manuel

Maite Baz Martínez

Virus y Senescencia celular 14/11/2016 Carmen Rivas, Manuel Collado

Edward Milbank Extracellular vesicles as a therapeutic strategy to prevent or reverse obesity and its metabolic complications in the field of nanomedicine

9/12/2016 Ramaroson Andriantsitohaina; López Pérez, Miguel Antonio

Guillín Amarelle, Cristina

Búsqueda de nuevos genes implicados en la etiopatogenia de los síndromes lipodistróficos infrecuentes

15/12/2016 Araujo Vilar, David; Fernández Marmiesse, Ana

Coelho Neves Gonçalves, Óscar Filipe

OBSESSIVE-COMPULSIVE DISORDER: NEUROIMAGING FINDINGS

15/12/2016 CARRACEDO ALVAREZ, ANGEL MARIA

Ebel Floridia MALFORMACIONES CAVERNOSAS CEREBRALES: ESTUDIO DEL GEN DE SUSCEPTIBILIDAD CCM3

16/12/2016 Juan Zalvide

Rodríguez Penas, Diego

REGULACIÓN DE LA VIABILIDAD Y EL METABOLISMO CARDIOMIOCITARIO POR FÁRMACOS (ALISKIREN) Y HORMONAS (CHEMERINA) CON CAPACIDAD DE MODULAR PROCESOS INFLAMATORIOS

19/12/2016 GONZÁLEZ JUANATEY, JOSÉ RAMÓN, Lago Paz, María Francisca

Cristina Iglesias García

Efectos metabólicos de Mst3 21/12/2016 Juan Zalvide, Celia M. Pombo

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b. Conferences

Frontiers in Science

Title Speaker Speaker information Date

Frontiers in Science: The genome editing revolution – how will it transform medicine and agriculture and how do we guard against potential perils?

Prof. John Parrington Associate Professor in Molecular Pharmacology, Oxford University, UK

15/07/2016

CiMUS Update

Happy Fridays

Title Speaker Speaker information Date Ceramides-Hypothalamic ER stress and brown adipose tissue "a HOT story about obesity"

Ismael González NeurObesity group (CiMUS) 29/01/2016

A newchemotherapy combination (U0126+SN50) potentiatesapoptosis in thyroid cancer bur induces survival in normal thyroid

Joana Sousa Neoplasia and Endocrine Differentation group (CiMUS)

26/02/2016

Title Speaker Speaker information Date Breast Cancer: role of Pit-1 and vitamin D


Endocrine Oncology group (CiMUS)

14/01/2016

The Renin-Angiotensin System (RAS) beyond blood pressure control. Brain RAS and Parkinson´s disease

José Luis Labandeira Parkinson Disease group (CiMUS)

18/02/2016

What do the brain and the gastrointestinal tract talk about? Metabolism, indeed

Rubén Nogueiras Molecular Metabolism group (CiMUS)

10/03/2016

83

Extracellular vesicles in nanomedicine as therapeutic strategy in metabolic disease

Edward Milbank Stress oxydant et pathologies métaboliques, INSERM, Université d'Angers (France) & NeurObesity group, (CiMUS)

13/05/2016

Interaction of Brain, Brown Fat and Vasculature

Sogol Gachkar Center of Brain Behavior and Metabolism (CBBM), University of Luebeck (Alemania) & NeurObesity Group (CiMUS)

27/05/2016

The androgenic tale of energy balance

Ahmed Hamed Arisha NeurObesity group (CiMUS) 01/07/2016

New potential nanotechnology-based therapies for the treatment of rheumatoid arthritis

Nataliya Storozhylova Nanobiopharmaceutical Research group (CiMUS)

15/07/2016

Impact of the aggregation state of amphotericin B on its biopharmaceutical properties

Henrique Rodrigues Marcelino

Nanobiopharmaceutical research group

25/11/2016

Seminars

Title Speaker Speaker information Date How to start Biotech company in Spain: the "Sagetis Biotech case".

Eduard Diviu CEO CFO Co-Founder and Chairman of the Board at Sagetis Biotech & Xavier Riveiro, BSc COO and partner at Sagetis Biotech

11/01/2016

Network Medicine por Peripheral Nerve Injury

Dra. Caty Casas Insituto Neurociencia, Universitat Autonoma de Barcelona

29/01/2016

Targeted delivery of nucleic acids

Elias Fattal University of Paris-Sud, Orsay (France)

26/02/2016

Dual role of aneuploidy un cancer

Dr Rocío Sotillo Division of Molecular Thoracic Oncology at the German Cancer Research Center, Heidelberg, Germany, and Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy

02/03/2016

Host-guest interactions between biomolecules and small molecules: a contribution from Computational Chemistry

Dr. Giampaolo Barone Universidad de Palermo (Italia)

15/04/2016

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Hypothalamic amino acid sensing in the regulation of energy balance

Dr. Clèmence Blouet MRC Metabolic Disease Unit, Institute of Metabolic Science, University of Cambridge (UK)

22/04/2016

Técnicas ómicas en la investigación clínica

Juan Angel Fresno y Angel Gámez-Pozo

(BiomedicaMM) 28/04/2016

Nuevos avances en el tratamiento inmunológico del cáncer

Dr. Javier Briones Universidad Autónoma de Barcelona

29/04/2016

Lipid-based nanomedicines for cancer treatment

Prof. María J. Blanco-Prieto

University of Navarra 03/05/2016

From the idea to the product: a personal perspective

Dr. Jeffrey Hrkach Moderna Therapeutics 04/05/2016

Fractalkine and addiction: Chemokines meet the hippocampus

Dr. Fernando Rodriguez de Fonseca

IBIMA (Málaga) 19/05/2016

ISGylation: A critical protein modification process in pancreatic cancer stem cells

Dr. Bruno Sainz Universidad Autónoma de Madrid

14/06/2016

Lean Body Neurons Dra. Ana Domingos Obesity Laboratory, Instituto Gulbenkian de Ciencia (IGC) (Portugal)

23/06/2016

Adicción a la comida y Trastornos de la Alimentación: Factores compartidos y diferenciales

Dr. Fernando Fernández-Aranda

Coordinador de la Unidad de Trastornos de la Alimentación Servicio de Psiquiatría, Hospital Universitario Bellvitge-HUB/IDIBELL, L'Hospitalet de Llobregat, Barcelona

26/07/2016

Adicciones conductuales y adicción a la comida: una relación compleja

Dra. Susana Jiménez-Murcia

Coordinadora de la Unidad de Adicciones Comportamentales, Servicio de Psiquiatría, Hospital Universitario de Bellvitge. Investigadora de IDIBELL L'Hospitalet de Llobregat, Barcelona

26/07/2016

Can A Defective Antenna Cause Obesity? Role of Cilia Proteins in Energy Homeostasis

Prof. Kamal Rahmouni Professor of Pharmacology and Internal Medicine, University of Iowa Carver College of Medicine. USA

22/09/2016

The Multifunctional Role of Astrocytes as Gatekeepers of the Control of Energy Metabolism

Dra. Cristina García Cáceres

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum Muenchen, Munich, Germany

30/09/2016

Nutrient signalling in metabolism and cancer

Dr. Alejo Efeyan Molecular Oncology Program, CNIO (Madrid)

28/10/2016

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«Mechanisms of tissue-specific and time-dependent metastasis»

Roger Gomis ICREA Research Professor, Head of Metastasis Laboratory, Institute for Research in Biomedicine of Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology

29/11/2016

PHd Programs Conferences

“BIOMEDICINE: BEYOND THE LABORATORY” PhD Programs: Endocrinology and Molecular Medicine

Title Speaker Speaker information Date "Cheating" significa fraude": Integridad en investigacion científica

Lluis Montoliu Comité Ético CSIC. Centro Nacional Biotecnología (CNB). CIBERER. Madrid

21/11/2016

"El desconocimiento de la ley no exime de su cumplimiento:" Legislación en experimentación animal

Jose Luis Villegas. Xefe de Inspección Veterinaria, A Coruña. Consellería de Medio Rural, Xunta de Galicia

22/11/2016

"Inbiomotion: from bench to spin off"

Roger Gomis ICREA Research Professor, Head of Metastasis Laboratory, Institute for Research in Biomedicine of Barcelona (IRB Barcelona), The Barcelona Institute of Science and Technology

29/11/2016

"An affair with the RANK pathway: novel applications of a known drug"

Eva González Suárez Group Leader Transformation and Metastasis lab. Cancer Epigenetics and Biology Program-PEBC. Institut d'Investigació Biomédica de Bellvitge-IDIBELL. Barcelona.

29/11/2016

"El desconocimiento de la ley no exime de su cumplimiento:" Legislación en experimentación con humanos.

Paula M. López Vazquez Secretaria del CAEIG (Comité Autonómico de Ética da Investigación de Galicia). SERGAS. Consellería Sanidade, Xunta de Galicia.

28/11/2016

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“ADVANCED EXPERIMENTAL MODELS AND PROTEOMICS IN NANOMEDICINE AND MOLECULAR MEDICINE” PhD Programs: Drug Research and Development; Molecular Medicine and Nanofar

Human cell and tissue models for the prediction of in vivo drug disposition

Dr. P. Lundquist Uppsala University 15/11/2016

Advanced animal models of human diseases

Prof. Anxo Vidal CiClON group, CiMUS 15/11/2016

Proteomics informed pharmacokinetic models

Dr. P. Lundquist Uppsala University, Sweden 16/11/2016

Investigation of intestinal permeation enhancers: from in vitro to in vivo

Dr. F. McCartney University College Dublin, Ireland

16/11/2016

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c. Other activities

PINT OF SCIENCE: International event which was organized for its second edition in

Santiago de Compostela 2016, 18th-20th May. Sulay Tovar was the chair of the

organitation committee, and Miguel González Blanco and Anxo Vidal were also

membersin of this committee.

Regueifas da Ciencia: They organize scientific debates about controversial issues with

the involvement of the public society. Miguel González Blanco, Sulay Tovar and Anxo

Vidal are part of the organitation committee.

88

IV BioSpeedDating Day: Organized by Bioga at CiMUS on 26th of May 2016

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7. ACTIVITY

a. Web page and Social Media: 1. Web page: We are increasing the contents of CiMUS web page to mantein

updated it with the activities of the center (http://www.usc.es/cimus/). 2016 was a year with a high increase in the visits, reaching 139.329 visits.

2. Facebook profile, (https://www.facebook.com/CIMUS.USC) is the most visited profile of the center with over 600 likes at the end of the year, almost the double than the previous year.


https://www.facebook.com/CIMUS.USC


https://www.facebook.com/CIMUS.USC/timeline

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3. Researchgate: The CiMUS profile continues to increase the number of CiMUS

researchers who join the active platform-profile. At the end of the year we

have more than 100 active profiles.

4. Twitter: Active since middle 2014, At the end of the 2016 had over 250

followers. https://twitter.com/cimususc

https://twitter.com/cimususc

https://www.researchgate.net/institution/University_of_Santiago_de_Compostela/department/Centro_de_Investigacion_en_Medicina_Molecular_y_Enfermedades_Cronicas_CIMUS

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5. Linkedin: At the same time than twitter, we started to run the CiMUS Linkedin profile, a network with a profesional profile orientation. Regardless this specifity, in 2016 we reach 207 followers. https://es.linkedin.com/company/cimus

6. Youtube chanel: This chanel was created to be a multimedia tool to present the groups of the center with video. In 2015 we launched the 2nd video, «Nanopharmaceutical Technology: towards safer and more efficacious medicines». The chanel got 1600 views, and 31 followers. https://www.youtube.com/user/cimususc





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b. CiMUS presentation to educative comunity: 1. Students from diferent centers have visited the CiMUS:IES Fontexeira(Muros),

Colexío Abrente (Porto do Son), Colexio Calasanz (A Coruña). 2. Also, a institute with a more oriented technology profile, FESAN, visited the

center to know the CiMUS labs and platforms. 3. A group of teachers from difent hihg schools, which were in a program from

the DOMUS, have visited the CiMUS as part of this actualization program.

4. UniStem Day: international event focused in the stem cells and directed to the high school students of all Europe.

c. CiMUS Presentation to the international community:

1. European Economic and Social Comittee: An delegation from European Economic and Social Comittee visits the center as a activity in the Meeting “Promover las empresas innovadoras y de rápido crecimiento:El papel de las agrupaciones dedicadas a la investigación intensiva”.

2. Center of Euro Regionals Studies (CEER): In the framework of meeting about Geography, Innovation and Econimic growth organized by the CEER the attendants visited the CiMUS

d. CiMUS as a hub in which different companies presented their new products

Seahorse and Agilent technologies 22nd of June of 2016

scientific report 2016 · gsk-fast track: the pis, mabel loza and Ángel carracedo, coordinators of...

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