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Page 1: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,
Page 2: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

SCIENTIFIC PROGRAMME

27 February 2020, Thursday

Opening Ceremony

14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University

14:35 – 14:40 İkram CENGİZ, President of Turkish Chemists Society

14:40 - 15:00 Zeynep ATABAY, Atabay

15:00 - 15:20 Prof. Dr. İlhan SATMAN, TÜSEB

15:20 – 15:30 Prof. Dr. Ramazan ALTUNDAŞ, Vice President of Turkish

Chemists Society

15:30 - 15:50 Harun KIZILAY, Ph.D., Vice President, Turkish Medicines

and Medical Devices Agency, Minister of Health

15:50 - 16:10 Eray KAPLAN, Vice President, Turkish Medicines and

Medical Devices Agency, Minister of Health

16:10 - 16:40 Prof. Dr. Yusuf BARAN, Rector, IZTECH

16:40 - 17:00 Dr. Hakkı GÜRSÖZ, President, Turkish Medicines and Medical Devices Agency, Ministry of Health

17:00 - 17:30 Coffee Break

1. Session

Session Chair: Prof. Dr. Ramazan ALTUNDAŞ

Opening Lecture

17:30 - 18:10

Prof. Dr. Herve GALONS, Université Paris Descartes “The Changing World of Kinase Inhibitors: Towards Selective Inhibitors”

Award Ceremony

18:10 - 19:00

Prof. Dr. Ramazan ALTUNDAŞ, Gebze Technical University “Turkish Chemists Society 3rd Research Incentive Award Ceremony”

“8th International Drug Chemistry Congress R&D Awards”

19:00 - 20:30

Dinner

Page 3: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

28 February 2020, Friday

2. Session

Session Chair: Assoc. Prof. Esen Bellur ATICI

09:00 - 09:40

Dr. Mike WEBB, Independent Consultant, London, UK

“Pharmaceutical Chemical Development - Challenges Over The Last 10 Years”

09:40 - 10:10

Prof. Dr. Ramazan ALTUNDAŞ, Gebze Technical University “A New Approach to The Synthesis of Ibrutinib”

10:10 - 10:30 Prof. Dr. Özdemir DOĞAN, METU “Pyrrolidines, Aziridines and Biological Activity”

WORKSHOPS

Atabay, Odeon Hall

11:00 - 12:00

Doğan TAŞKENT

“Discuss and Determine the Building Blocks of Strategic API Manufacturing In Turkey”

10:30 - 11:00

Coffee Break

3. Session

Session Chair: Prof. Dr. Ali ÇAĞIR

11:00 - 11:40

Prof. Dr. M. Laura BOLOGNESI, University of Bologna

“Multi-Target-Directed Ligand Design Strategy in Alzheimer’s Disease: Lessons Learned and Challenges Ahead”

11:40 - 12:10

Prof. Dr. Erden BANOĞLU, Gazi University

“Discovery of Multitarget Inhibitors in the Arachidonic Acid Pathway by Targeting FLAP/5-LO/mPGES-1 for Intervention with Inflammatory Deregulation”

12:10 - 12:30

Assoc. Prof. Atilla AKDEMİR, Bezmialem Vakıf University

“The Quest for Structurally Novel Lead Compounds Against Breast Cancer”

12:30 - 14:00

Lunch

Page 4: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

4. Session

Session Chair: Prof. Dr. Aliye ALTUNDAŞ

14:00 - 14:40

Asst. Prof. Marco PIERONI, Università di Parma “Discovering New Chemotypes That Selectively Inhibit Microbial Carbonic Anhydrases”

14:40 - 15:10

Prof. Dr. Ali ÇAĞIR, IZTECH

“Klavuzons: Multitarget Covalent Inhibitors”

15:10 - 15:30

Assoc. Prof. Dr. Serhan TÜRKYILMAZ, METU “Zinc(II)-Bisdipicolylamine Complex Bearing Agents for Selective Agglutination, Imaging, and Photodynamic Inactivation of Bacterial Cells”

15:30 - 16:00

Coffee Break

WORKSHOPS

Ashland, Odeon Hall

14:00 - 15:30

Enis DEMİR

“Novel Ultra High Speed Film Coating Systems to İncrease Productivity, AquariusTM Genesis” Nadin EKMEKÇİYAN “Binder Selection for Today’s Formulation Challenges”

5. Session

Session Chair: Assoc. Prof. Serhan TÜRKYILMAZ

16:00 - 16:40

Prof. Dr. Orazio NICOLOTTI, University of Bari

“A Similarity-Based Reverse Screening Method to Predict Protein Drug Targets”

16:40 - 17:00

Prof. Dr. Mükerrem Betül YERER, Erciyes University

“Monoclonal Antibodies and Targeted Therapies in Anticancer Drug Discovery”

Page 5: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

17:00 - 17:15

Dr. Gökçe YILDIRIM BUHARALIOĞLU, Ege University

“Epigenetic Regulation of Matrix Metalloproteinases in LNCaP Human Prostate Cancer Cell Line”

17:15 - 17:30

Nazlıcan TEZGEL, Abdi Ibrahim Pharmaceuticals

“Stability Studies for Biologics”

6. Session

17:30 - 18:30

Short Oral Presentations

Session Chair Session Chair Session Chair Session Chair

Prof. Dr. Aliye ALTUNDAŞ, Phoenix I Prof. Dr. Nermin Şimşek KUŞ, Phoenix II Prof. Dr. Tijen ÖNKOL, Mirage I-II Prof. Dr. Özlen GÜZEL-AKDEMİR, Odeon

18:30 - 19:30

Dinner

19:30 - 21:30

Poster Presentations, Mirage I-II

29 February 2020, Saturday

7. Session

Session Chair: Prof. Dr. M. Betül YERER

09:00 - 09:40

Dr. Staffan KARLSSON, Astra Zeneca

“Continuous Processing and Real Time Monitoring of Hazardous Chemistry”

09:40 - 10:00

Dr. Yağmur KİRAZ, IZTECH “Overcoming Drug Resistance in Leukemia: A Molecular Approach”

10:00 - 10:15

Dr. Belgin SEVER, Anadolu University

“Design, synthesis and aldose reductase inhibitory activity of new triazole derivatives”

10:15 - 10:30

Asst. Prof. Özlem AKGÜL, Ege University “Inhibition Studies of 2-Aminoethanesulfonic Acid Derivatives Against Some Carbonic Anhydrase Isoforms”

Page 6: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

10:30 - 11:00

Coffee Break

WORKSHOPS SEM, Odeon Hall

10:00 - 10:45 11:00 - 11:45

Selim KARACA

“Lyophilization Systems for the Pharmaceutical Industry” Kaan GÜNER

“Data İntegrity Traceability and Security in Pharma”

8. Session

Session Chair: Prof. Dr. Özdemir DOĞAN

11:00 - 11:40

Prof. Dr. Joachim JOSE, Westfälische Wilhelms-University Münster “Bivalent Inhibitors of Human Protein Kinase CK2, an Emerging Target in Cancer”

11:40 - 12:10 Prof. Dr. Süreyya ÖLGEN, Biruni University

“Drug Repurposing in the Development of Anticancer Agents”

12:10 - 12:30

Assoc. Prof. Nurettin MENGEŞ, Van Yuzuncu Yil University “New Types of Imidazole Derivatives and Their Pharmacological Effects on Central Nervous System”

12:30 - 14:00

Lunch

9. Session

Session Chair: Assoc. Prof. M. Dilek ALTINTOP

14:00 - 14:30

Prof. Dr. İlkay ERDOĞAN, Gazi University

“Plant Metabolites at Target in Drug Discovery Process: From Field to Clinic”

14:30 - 15:00

Prof. Dr. Erdal BEDİR, IZTECH

“Developing New Drug Candidates from Triterpenic Sapogenols via Microbial Biotransformation and Semi-synthesis ”

15:00 - 15:30

Assoc. Prof. Serdar SEZER, Süleyman Demirel University “Medical Applications, Pharmacological Properties and Purification of Cannabidiol”

Page 7: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

15:30 - 16:00 Coffee Break

WORKSHOPS SEM, Odeon Hall

14:00 - 14:45 15:00 - 15:45

Serdar BİLGESOY “Analysis of 5-Nitrosamines Impurities in Pharmaceutical Products” Halil KIZILARSLAN

“Agilent Raman Spectroscopy Solutions in pharmaceutical QC”

10. Session

Session Chair: Prof. Dr. Erden BANOĞLU

16:00 - 16:40

Assoc. Prof. Antimo GIOIELLO, University of Perugia

“Bile Acids and The Chemistry They Inspire to Discover New Chemical Entities”

16:40 - 17:00

Gökhan BAYRAK, Abdi Ibrahim Pharmaceuticals “Presentation at Case Study of Utilizing DVS in Evaluation of Alternative Source Studies of Active Pharmaceutical Ingredient of a Medicinal Product and Troubleshooting of Observed Differences for Manufacturing Process among the Sources”

17:00 - 17:15 Gürmen KAYNAR, Worldmedicine “From Molecule to Drug; Patent”

17:15 - 17:30

Asst. Prof. Burçin TÜRKMENOĞLU, Erzincan Binali Yildirim University “4D-QSAR and Molecular Docking Studies on Some Steroidal Derivatives”

17:30 - 17:45

Prof. Dr. Şeniz ÖZALP YAMAN, Atılım University “New DNA Targeted Antitumor Agents of Platinum and Copper”

17:45 - 18:00

Asst. Prof. Safacan KOLEMEN, Koç University

“Cancer Cell Selective Photodynamic Therapy Agents”

Page 8: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

18:00 - 18:15

Kübra Demir YAZICI, İstanbul University

“Inhibition of the α-class Carbonic Anhydrase from Vibrio cholera(VchCA) with Novel Sulfonamido based Hydrozones”

18:15 - 18:30

Dr. Serkan DAYAN, Erciyes University

“Microwave-Assisted Rapidly Hydroxyapatite Fabrication in Natural Media and Investigation of Drug-Carrying Capacity”

18:30 - 18:45

Ece PEMBECİOĞLU, Vefa İlaç

“Traditional and herbal medicinal products and industry approach”

Career Talk 2020 SEM, Mirage Hall

18:45 - 19:45

Zafer KARKAÇ, LSC Group Manager

18:45 - 19:30

Dinner

19:30 - 21:30

Poster Presentations, Mirage I-II

01 March 2020, Sunday

11. Session

Session Chair: Prof. Dr. Hamdullah KILIÇ

09:00 - 09:40

Sandro O. LAISO, Intertek

“Analytical Approaches for Reliable Screening and Control of Genotoxic İmpurities”

09:40 - 10:00

Prof. Dr. Ahmet C. GÖREN, Bezmialem Vakıf University “Reliability and Validity of Dietary Supplements”

10:00 - 10:15

Dr. Sıtkı Doğa ELÇİ, LumiLabs “Investigation of The Activation Mechanisms of Natural Clotting Processes by Highly Deacetylated Chitosan”

10:15 - 10:30

Therese TRAN, Kromasil “Investigation of Impurity Profiles in Preparative HPLC Applications of Peptide APIs”

Page 9: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

10:30 - 11:00

Coffee Break

12. Session

Session Chair: Dr. O. Mutlu TOPAL

11:00 - 11:40 Dr. Lance SMALLSHAW, UCB S.A., Wallonia, Belgium

11:40 - 12:00

Gül Gönül KAYAR, Abdi Ibrahim Pharmaceuticals “In Vitro Comparative Nasogastric (NG) Tube Study for Film Coated Tablets Containing Platelet Aggregation Inhibitor”

12:00 - 12:15 Asst. Prof. İrem KULU, Gebze Technical University “Bioorthogonal Nanozymes: Synthesis and Kinetic”

12:15 - 12:30

Büşra CESUR, Akdeniz University “Preparation and Safety Evaluation of Nano-niosomes for Biotechnology-derived Medicinal Products and Cosmetics”

12:30 - 14:00

Lunch

13. Session

Session Chair: Assoc. Prof. Dr. Nurettin MENGEŞ

14:00 - 14:15

Assoc. Prof. Salih ÖZÇUBUKÇU, METU “Simple Amino Acid Based Low Molecular Weight Organogel as Drug Delivery Systems”

14:15 - 14:30

Asst. Prof. Süleyman AKOCAK, Adiyaman University “Potent and Selective Inhibition of Carbonic Anhydrase Isoforms by Using 1,3,5-triazine and 1,3-diaryltriazene Substituted Sulfonamides”

14:30 - 14:45

Dr. İlke Uğur MARION, METU “Problem Specific Computational Chemistry Solutions in Drug Design”

14:45 - 15:00

Dr. Burcu BİNİCİ, TUBİTAK National Metrology Institute

“Production of Certified Reference Material for The Measurement of Aminoacids And Neurotoxic Aminoacids in Lentil”

Page 10: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

15:00 - 15:15

Ömer SONKAYA, Aksaray University “Design and Synthesis of a Novel NIR Dye”

15:15 - 15:30

Muhammed TRAWALLY, İstanbul University

“Synthesis and Inhibitory Activity of 2-(Alkylidene/arylidene)-N-(2-(non)substituted-3/4-sulfamolylphenyl) Hydrazine Carbothioamide derivatives as Tumor-associated Carbonic Anhydrase hCA IX and hCA XII Inhibitors”

15:30 - 15:45

Zinnet Şevval AKSOYALP, Akdeniz University “Effects of Vorapaxar Incubation on Human Left Internal Mammary Artery Endothelial Function”

15:45 - 16:30

Closing Ceremony and Poster awards

Your poster will be tacked to a 100 cm (tall) x 70 cm (wide) board so therefore should not exceed the measurement of the board. Your poster should be placed at the poster board with number corresponding to the conference agenda and available for viewing by attendees througout the conference. Authors are expected to be present at their poster during the poster session on Friday and Saturday at 7:30 pm. Poster awards will be given at the closing ceremony.

ORAL PRESENTATION PROGRAMME

Presentation Hall: Phoenix I

POSTER NO Author Title

OP1 Hatice BEKÇİ The Effect of Sistein Carbon Dots on Cell Survival of A549 and Beas-2b Cell Lines

OP3 Gizem DİNLER DOĞANAY Phosphorylation dependent interaction of pro-survival Bag-1 isoforms with MAPkinases

OP4 Jale YILDIZ Identification of the Recurrent VUSs in CHEK2 Gene in Breast Cancer Patients

OP6 Zeliha Nur YILMAZ In silico Molecular Docking, ADME and Druglikeness Properties of Aromatic Schiff Bases

OP8 Gozde YENİCE CAKMAK Synthesis, and Molecular Docking Studies of Some Novel Benzothiazoles as HDAC Inhibitors

OP9 Sergen GÜL Catalyst-free and green chemistry approach for unknown fused tetraheterocyclic skeleton

OP10 Beyza SIMSEK Synthesis and Evaluation of In vitro Antiproliferative Activity of Some Bisbenzazol Derivatives as Topoisomerase Enzyme Inhibitors

OP11 Serdal KAYA A New Strategy for the Synthesis of Beta- and Gamma-Carbolines

OP12 Dilek AKBASLAR Synthesis and Evaluation of Antimicrobial Properties of Some Indolyl Chalcone Derivatives

OP13 Dilek AKBASLAR Synthesis of Tetrasubstituted Pyrroles and Pyrrole-Based Chalcones and Investigation of Their Cytotoxic Effects on MCF-7 Cell Line

OP14 Havva KURT An Investigation For New Topical Antiseptic Solution with Unknown Agents

Page 11: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

OP15 Yakup BUDAK Synthesis, characterization of hydroxyapatite and comparison with commercial hydroxyapatite sample

OP16 Yakup BUDAK Anti-fungal activities of Marrubium vulgare L. different solvent extracts against plant pathogenic fungi

OP17 Nebih LOLAK 1,3,5-Triazin Türevi Üreido Benzen Sülfonamitlerin Sentezi, Antioksidan, Asetilkolinesteraz, Bütirilkolinesteraz ve Tirozinaz Enzim Aktivitelerinin Araştırılması

OP18 Karina I S AMUDİ New Synthetic Route For Pyrazolo[1,5-a]pyrazine-2-carbohydrazide Derivative

OP19 Büşra ÖZTÜRK AYDIN Synthesis Of N-Alkylated Pyrazolo[3,4-d]pyrimidin Derivatives

OP20 İrfan KOCA Experimental and theoretical characterization and molecular docking studies of novel sulfonamide derivatives

OP21 Gizem Tuğçe ULU The Challenges of Drug Application in Targeted Cancer Treatment and Differentiation of Cell Morphology

OP22 Fatma ALBAYRAK Synthesis of Maleimide-Based Heterocyclic Molecules and Investigation of Their Anti-Cancer Activities

OP23 Ömer Tahir GUNKARA Synthesis of Substituted Bis(heteroaryl)maleimide Derivatives as Glycogen Synthase Kinase-3β Inhibitors With Potential Role as Anticancer Agents

OP24 Yaren CABBUR Synthesis of bicyclic aldehyde derivatives from quasi favorskii reaction; Investigation of their antioxidant activities

Presentation Hall: Phoenix II

POSTER NO Author Title

OP25 Aişe ÜNLÜ Antimicrobial Effect of Green Synthesis of Silver Nanoparticles Using Pomegranate Peel Extract

OP26 Burak KUZU Design and Synthesis of Novel 4-Methylaminopiperidine-Substituted Imidazopiridine Derivatives and Investigation of Their Antimicrobial Activities

OP27 Burak KUZU Design and Synthesis of Novel Diisopropyloxalamide Derivatives and Their Docking Studies for COX Inhibitions

OP28 Osman Nuri ASLAN Synthesis and anticancer activity of novel urea derivatives

OP29 Osman Nuri ASLAN Synthesıs, Characterızatıon And Investıgatıon Of Bıoactıve Propertıes Of Urea Based New Hybrıd Molecules

OP30 Mesut ŞENTÜRK Cytotoxic and Antiproliferative Activity of N- (4-Chlorophenyl) -1 H-Indole-2-Carboxamide on Prostate and Osteosarcoma Cell Lines.

OP31 Saffet ÇELİK Determination 42 Amino Acids in Royal Jelly from Different Regions of Turkey

OP32 Bunyamin OZGERİS Synthesis of Some Carbamates From Substituted Phenethylamines

OP33 Mustafa Kemal GÜMÜŞ 1,3-nükleofil olarak 3-amino-1,2,4-triazol’ün modifiye Biginelli reaksiyonları

OP34 Zekiye Şeyma SEVİNÇLİ Design, Synthesis And In Vitro Applications Of New Types Of Cell Imaging Agents: Imidazopyridine Skeleton

OP35 Burçin TÜRKMENOĞLU Synthesis of Heterocyclic Compounds and 4D-QSAR Study

OP36 Zehra ÖKSÜZ Evaluation of Reverse Transcriptase Inhibitor Nucleoside Analogue Resistance Profile in HBV Patients with HCMV/EBV Coinfection

OP37 Ufuk ATMACA A Safe Alternative for The Synthesis of Primary Carbamates From Alcohols

OP38 Hamdi ÖZKAN 1-(2-(5-(4-Sübstitüefenil)-1H-tetrazol-1-il)etil)amin Bileşiklerinin Sentezi Karakterizasyonu ve Biyolojik Özelliklerinin Araştırılması

OP39 Ali Enis SADAK Live Cell Imaging

OP40 Özge ÇAĞLAR Activity and stability enhancement by chemical modification of the Candida rugosa Lipase

Page 12: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

OP41 Elif ÖZYİLMAZ Immobilization of Candida rugosa lipase on Calix[4]aren functionalized water-soluble iron oxide magnetite nanoparticles for enzymatic resolution of (R,S)-Naproxen methyl ester

OP42 Murat KIRANŞAN Removal of Antibiotic Drug Wastes from Aqueous Solutions by Photocatalytic Ozonation Process

OP43 Murat KIRANŞAN A review on the Removal of Pharmaceutical Wastes from Aqueous Solutions under the Effect of Different Nanocomposite Catalysts of Sonocatalytic Degradation

OP44 Mehmet KUZUCU Synergistic Anti-proliferative and Anti-Cancer Effects of Gambogic Acid with Capecitabine in MDA-MB-453 Human Breast Cancer Cells

OP45 Alim SUSAM Towards a multi-emissive drug

OP46 Arzu GÖBEK Synthesis of Flouro-Substituted Bis-Chalcone Derivatives as an Antiproliferative Agent

Presentation Hall: Mirage I-II

POSTER NO Author Title

OP47 Mehmet OGUZ The Synthesis of Cationic Calix[4]arene Derivatives and Evaluation of Their Cytotoxic Potential for Human Cancerous Cells

OP48 Mehmet ERŞATIR Novel Coumarin-Selenophene Hybrids as Potential Antiproliferative Agents: Synthesis and Biological Evaluation

OP49 Özgür YILMAZ α-C-H cyanation of tertiary amines with a new method

OP50 Erdin DALKILIÇ Synthesis of Novel Molecular Clip Based on Norbornadiene Framework

OP51 Bilal NİŞANCI

Transition Metal Nanoparticles Supported on Metallic Aluminum Nanoparticles Intercalated Two-Dimensional Carbon Support Materials as Catalysts for the New Generation of Transfer Hydrogenation Reactions

OP52 Bilal NİŞANCI A Facile and Highly Efficient Dehalogenation of Halides Catalyzed by Palladium Nanoparticles Supported on Mesoporous Graphitic Carbon Nitride

OP53 Yusuf AKBABA Synthesis of Novel Symmetrical Sulfamides Derived 2-Aminotetralins

OP54 Sinem ÜMİT Synthesis of bicyclic haloalcohols from ketene addition reaction; Investigation of their antioxidant activities

OP55 İrfan ÇAPAN Synthesis of Potential Biologically Active Molecules; Thiosemicarbazide and 1,2,4-Triazole Derivatives Having the Carbazole Hybrid.

OP56 Gönül YAPAR Based Imine Compounds

OP57 Gönül YAPAR Synthesis of New Bis-Schiff Base Podands and Investigation of Their Antioxidant Activity, Biological and Anion Sensor Properties

OP58 Nalan İmamoğlu The Contrast Effects of Pre- and Post- Treatment with Dexamethasone on the Expressions of Interleukin (IL)-6, IL-8 and Eotaxin-1 in Lipopolysaccharide-Stimulated BEAS-2B Cells

OP59 Onur DEMİRKOL Extraction of Furanocoumarin and Coumarins by Subcritical Water Extraction from Ruta chalepensis

OP60 Sinan BİLGİNER Synthesis, Cholinesterase Inhibition and Molecular Docking Studies of Novel Mannich Bases of Banzoxazolone Chalcone Compounds

OP61 Burak ARABACI Determination of Sapropterin Dihydrochloride in Solid Dosage Forms by Visible Spectroscopy

OP62 Aysun DEGIRMENCI Polymer Drug Conjugates for Pancreatic Cancer Therapy

OP63 Enfal ÖZER Antibody-Drug Conjugates As Targeted Drug Delivery Agents

OP64 Ümit BABACAN Variations of Ferulic Acid in Traditional Turkish Wheat Species

Page 13: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

OP65 Ümit BABACAN Cell Viability Effects of Ferulic Acid on Melanoma Cell Line (SK-MEL-30)

OP66 Ümit BABACAN A Sensitive Determination of Cannabidiol (CBD) by HPLC

OP67 İrem NAMLI An Approach for Solubility Enhancement of Poorly Water-Soluble Drug Cefdinir with Polyvinyl Alcohol

OP68 Ülkü ÇAYKÖYLÜ A Review of Quantum Dot Based Nano-Biosensors

Presentation Hall: Mirage I-II

POSTER NO Author Title

OP69 Salli GÜR Antibody Polymer-Drug Conjugates As Targeted Chemotherapy Agents

OP70 Erbay KALAY Palladium Nanoparticles Assembled on Mesoporous Graphitic Carbon Nitride: A Highly Efficient Heterogeneous Catalyst for the Stille Coupling Reaction

OP71 Malak ALIZADA The Synthesis of Calixarene Based Non-Toxic Fluorogenic and Colorimetric Dual-Channel Chemo-sensor and its Applications in Bioimaging

OP72 Meltem TAN Novel Synthesis Method For 5,6-Substitue Heterobicyclic Compounds

OP73 Meltem TAŞ Anadolu Kestane ve Narenciye Ballarının Glisemik İndeksleri

OP74 Begüm Hazar ÇİFTÇİ Liquidambar orientalis reçinesinin üreaz enzim inhibisyon aktivitesi

OP75 Göksun DEMIREL Metamfetamin Bağımlılığın Tedavisinde Terapötik Aday :mikroRNA- Let7b-3p

OP76 Mine BUĞA Synthesis of Benzimidazole-2-Phenyl with Alkyl / Alkyloxy linker Derivatives and Their Investigation of Antiproliferative Effect

OP77 E. Vildan BURGAZ Yeni 7,11-diaril-3-tiyookso-2,4-diazaspiro[5,5]undekan-1,5,9-trion Bileşiklerinin Sentezi

OP78 Pelin VURAL Selectıng “Worst Case” For Equıpment Cleanıng Valıdatıon

OP79 Efe Doğukan DINCEL Novel 4-thiazolidinones and 1,3,4-oxadiazoles: Synthesis, theoretical evaluation of ADME properties and docking study

OP80 Ersin DEMIR The electrochemical behaviour and determination of bupivacaine ophthalmic drug by square wave voltammetry on glassy carbon electrode

OP81 Emre ÜNLÜ Determination of anthrax by strong luminescence of lanthanide phosphorescence

OP82 Şeyma OCAKÇI Design and synthesis of a new chemiluminogenic probe for hypochlorite

OP83 M. Fatih POLAT Design, Synthesis and Determination of Bisbenzazol Derivatives for Antiproliferative and Antimicrobial Activity

OP84 Tansu DOĞAN Development of Practical Electrochemical System for Phenytoin Detection

OP85 Tansu DOĞAN

Preparation and Characterization of Metal Oxide Nanoparticles Modified Carbon Nanotube-Conducting Polymers Based Composite Electrode For Simultaneous Determination Of Melatonin And Caffeine

OP86 Nilgun KARASU Effect Of Tamoxifen-Gambogic Acid Combinations on Antiproliferative Activity in Estrogen Receptor-Positive Breast Cancer Cells

OP87 Eren BOSTANCI Investigation of the Effects of BK369 Compound on Breast Cancer

OP88 Yakup KAPTAN Synthesis of 3,5-Diarylsubstituted İsoxazoles as an Anticancer Agent

OP89 Derya AKTAŞ ANIL Synthesis and Investigation of Anticancer Properties Fluoro Substitued Bis-Chalcone Derivatives

OP90 Derya AKTAŞ ANIL Elucidation of Chemical Structures of Some Chalcones Compounds by NMR Spectroscopy

Page 14: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

POSTER PRESENTATION PROGRAMME

Poster No

Author

Title

P2 Hatice BEKÇİ The Effect of Pt-Au Bimetalic nanoparticules of Curcuma Longa extract Cell Survival of A549 and Beas-2b Cell Lines

P5

Gizem DİNLER DOĞANAY Development of a Practical Capillary Zone Electrophoresis Method to Determine Charge Variant Profiles Under Forced Degradation Conditions for Monoclonal Antibodies

P7

Zeliha Nur YILMAZ Investigation of Functional Models for the Catalase, Catecholase and Phenoxazinone Synthase Enzymatic Activities

P91 Muhammed TUNEĞ Aromatik Yapıya Sahip Bis-Sülfonamit Schiff Bazı Türevlerinin Sentezi, Antioksidan, Asetilkolinesteraz ve Bütirilkolinesteraz Aktivitelerinin Araştırılması

P92 Eylem Esin YÜCESOY Astım İlaç Etken Maddesi Olan Tomelukast’ın Benzer Bileşiklerinin Sentezi ve Yapılarının Aydınlatılması

P93 Burçin KIVANÇ Comparison of Sink Condition Solubility Studies of A Direct Factor Xa Inhibitor Molecule By Traditional Solubility Methodology And Compendial Apparatus

P94 Yonca TARAMAN Artvin Yöresinde Yetişen Bazı Yenilebilir Mantarların Metal Konsantrasyonu ve Toplam Fenolik İçeriğinin Belirlenmesi

P95 Canan ALTUNTAŞ Yeni triazol-salisiliden Schiff bazı türevlerinin çevreye duyarlı sentezi ve yapılarının aydınlatılması

P96 Elif Tuğçe ERDEVE Molecular modelling studies to identify novel inhibitors of the human 26S proteasome complex

P97 Özlen GÜZEL AKDEMİR The Ongoing Quest for Selective hCA IX/XII Inhibitors

P98 Serenay AKYOL Development of a Reversed Phase UHPLC Method As an Alternative of Normal Phase HPLC Method For Vitamin D3 (Cholecalciferol) 50000 IU/15 ml Oral Drop Assay Analysis

P99 Handenur YILMAZ The One Pot Synthesis and Antioxidant Activity Determination of Novel Benzothiazine Derivatives

P100 Nursena MUTLU Yeni Benzoksazin Türevlerinin Sentezi ve Antibakteriyel Etkilerinin Araştırılması

P101 Gülnur DANDİN Synthesis and Antibacterial Activity of New Sulfonamide Derivatives Containing Thiazolidine Ring

P102 Belma ZENGİN KURT Synthesis and Cytotoxic Activity of Novel Flurbiprofen Derivatives Containing Urea Group

P103 Belma ZENGİN KURT Synthesis and Cytotoxic Activity of New Sorafenib / Ruthenium Complexes

P104 Suray JUMAMYRADOVA The One-Pot Synthesis and DNA- Interaction of Novel Benzoxazine Derivative.

P105 Gulsah AYDİN Use of Lecithin as Emulsifier in Herbal Cream Production

P106 Sümeyye TURANLI Synthesis of New Vicinal Diaryl Five-Membered Heterocyclic Compounds with Potential Anticancer Activity

P107 Gökçe UZUNAY The search for novel inhibitors of the human 26S proteasome complex

P108 Ali DİŞLİ Bazı Tiyotetrazol Türevi Bileşiklerin Antimikrobiyal Aktivitelerinin Belirlenmesi

P109 Emre ÖZCANLAR Method Validation of Establishing the Sterilization Dose in Gamma Sterilization Process for Medical Device (Class III)

P110 Gülnur ARSLAN Synthesis of 3-Substitued-5-Chloro-2-(3H)-Benzothiazolone Derivatives

P111 Demet CANSARAN DUMAN The Comparison of miRNAs That Respond to Anti-Breast Cancer Drugs and Usnic Acid For The Treatment of Breast Cancer

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P112 Demet CANSARAN DUMAN The role of usnic acid in regulating apoptosis of SKBR-3 breast cancer cell

P113 Ayca DEDEOGLU Novel 3,5-Disubstituted-1,3,4-Oxadizoles: Synthesis, Anti-inflammatory Activity and Enzyme Interactions

P114 Duygu YALÇINKAYA YAVUZ Development of a Practical Capillary Zone Electrophoresis Method to Determine Charge Variant Profiles Under Forced Degradation Conditions for Monoclonal Antibodies

P115 Seminay GÜLER Real Time Kinetic Analysis of Biosimilar Drugs Based on Surface Plasmon Resonance (SPR)

P116 Sultan ÇETİN Development of Glutathione Selective Silicon-Fluorescein Based Photodynamic Therapy Agents

P117 Ali Osman SARIKAYA Stabilization of Cyclic Lipopeptide Antibiotic Powder for IV Injection with the Lyophilization Process

P118 Ulvi MEHDİZADE Determination of roflumilast by a new HPLC metho

P119 Ebru İLHAN LALE Yumuşak Kapsül Formlu Ürünlerin Çözünme Testi Analizinde Oluşabilecek Çapraz Bağlanma Problemine Çözüm Yaklaşımları

P120 Filiz ÇALIK Dendron−Polymer Conjugate Based Cross-Linked Micelles: A Versatile Nano Carrier for Targeted Delivery

P121 Toghrul ALMAMMADOV Resorufin Dye in Photodynamic Therapy: An Enzyme Activatable Photosensitizer for Selective Cytotoxicity

P122 Burak ÇOBAN A Novel Benzimidazole-Benzothiadiazole Derivative: Synthesis, Characterization, DNA Interaction and Cytotoxic Activity Studies

P123 Gizem KURŞUNLUOĞLU Terapötik Monoklonal Antikorların Analitik Karakterizasyonu

P124 Elçin ÇAĞATAY Synthesis and Characterization of Murryaquinone-A Derivatives and Determination of Their Biological Activity

P125 Oğuz ERDOĞAN Design of potential inhibitors of mTOR using molecular modelling studies

P126 Oğuz ERDOĞAN Evaluation of Metabolites Produced by Fungal Biotransformation of Apigenin and Fisetin and Their Cytotoxic Activities

P127 Sevil İRİŞLİ Antikanser Aktiviteye Sahip Yeni Pt(II)-Benzimidazol Kompleksleri

P128 Ahmet Fatih ŞAHİN Designing Potential hIKK2 Inhibitors Using Molecular Modelling Studies

P129 Ahmet ÖZDEMİR Synthesis, In vitro and In silico Evaluation of A Series of Pyrazolines as New DPP-4 Inhibitors

P130 Hasan SOYBİR New Pyrazole-Based Thiosemicarbazone Derivatives as Anti-Breast Cancer Agents

P131 Kübra ORAL Determination of Anticolorectal Cancer Effects of New Imidazole-Based Thiazolyl Hydrazone Derivatives

P132 Mustafa OZTURK The Therapeutic Potential of C-Pycocyanin for Acute Lymphoblastic Leukaemia Cells

P133 Gülsen Deniz KAHRAMAN Kazdağları Esintili Krem

P134 Selingün ÇAKIR Biyoaktivite Potansiyeli Olan Yeni Amino Tiyofenlerin Sentezi ve Yapılarının Aydınlatılması

P135 Gülay BULUT Combination Treatment with YK-4-279 Enhances Cisplatin Chemosensitivity in A549 Non-Small Cell Lung Cancer Cell Line Through Alteration of EGFR-STAT3 Signaling Pathway

P136 Ömer AVŞAR Unraveling the Molecular Requirements of Selective Recognition of Antigen A by its Antibody Using Molecular Modelling Studies

P137 Hande GUNDUZ Hemicyanine Based Phototheranostic Agents for Cancer Imaging and Therapy

P138 Nursefa Zengin The use of BINAP.PdCl2 as a homogeneous catalyst for the reduction of nitroaren in aqueous medium

P139 Remzi Burak ÖZTÜRK Design, Synthesis and Evaluation of A New Series of Tetrazole-Hydrazone Hybrids as Potential Cytotoxic Agents on PC-12 Cells

P140 Ecem KUZPINAR In Vitro Diffusion Test Study Using Franz Diffusion Cell System for a Non-Steroidal Anti-Inflammatory Prodrug Ophthalmic Suspension

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P141 Mehmet GÜMÜŞ The Synthesis and Characterization of Potential Anticancer Agents Bearing Pyrazole and Benzo Diazepine Heterocyclic Structures

P142 Mehlika Dilek Altıntop A New Series of Thiazole-Based ABL1 Kinase Inhibitors as Antitumor Agents against Chronic Myelogenous Leukemia

P143 Aykut DEMİRKIRAN Structural Characterization of Monoclonal Antibody by ESI-Q-TOF

P144 Nur Hilal OLGUN Molecular Docking Studies of Some Strigolactone Analogous as Cdk5 Inhibitors: Potential Lead Evaluation Related to Tau Hyperphosphorylation in Alzheimer Disease

P145 Tuğçe TUĞLU YENİGÜN Effects of Formulation Parameters on the Release of Metformine From Encapsulated Microparticles

P146 Enis IŞIK Stable NanoEmulsion Production And Optimization Of Droplet Size Distribution

P147 Merve ÇITAK Quality by Design Approach for Analytical Method Development in Liquid Chromatography with Drug Product Containing Nicotine Receptor Antagonist

P148 Erez UZUNER Determination of Effects of Nilotinib and SK-1 II on Human Telomerase Reverse Transcriptase (hTERT) in Acute Lymphoblastic Leukemia Cells

P149 Amani AMAMRA Antimicrobial activity and total phenolic content of aqueous extract of Amaranthaceae

P150 Polen YUNUS Possible Use of Nilotinib Against HER2+ Breast Cancer Cells

P151 Aliye ALAYLI ALTUNDAŞ M. Tuberculosise Karşı Antimikrobakteriyal Etki Gösterebilecek (1-Benzil-1H-1,2,3-triazol-4-il)(furan-2-il)metanonların Sentezi

P152 Güler YAĞIZ (1-Benzil-1H-1,2,3-Triazol-4-il)(Fenil)Metanon Türevlerinin Sentezi ve Mycobacterium Tuberculosis Basili Üzerine Etkilerinin İncelenmesi

P153 Nalan YILMAZ Synthesis and Evaluation of A Series of Thiazole Derivatives as New Apoptotic Anticandidal Agents

P154 M. Mustafa SÜNGÜ Comparison of Tetrazolium (MTT) and Sulforhodamine B (SRB) Protein Assays for Assessing in vitro Cell Viability

P155 Anisa AZIMI Preparation of the Inclusion Complexes of Water Soluble Calix[4,8]arene L- Proline Drtivatives and Quercetin: Solubility, Cytotoxic effect

P156 Handan SEZEN Anjiyotensin Dönüştürücü Enzim Inhibitörleri Ve Kalsiyum Kanal Blokerleri Kombinasyonu Prosesinde İkili Etkin Madde Uyumsuzluğunun Giderilmesine Yönelik Proses Optimizasyonu

P157 Murat VARDAR Development of A Parenteral Nutrıtıon Product Wıth an Optımızed and Sustaınable Productıon Technıque by Qbd (Qualıty By Desıgn)

Page 17: SCIENTIFIC PROGRAMME...SCIENTIFIC PROGRAMME 27 February 2020, Thursday Opening Ceremony 14:30 - 14:35 Prof. Dr. Öztekin ALGÜL, Chair, Mersin University 14:35 – 14:40 İkram CENGİZ,

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