science reporters’ workshop - genome.gov · media day, unlocking life's code, science...
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1 | Life Technologies™ Proprietary and Confidential 6/18/13
Science Reporters’ Workshop: State of the field of genome sequencing industry
Gregory T. Lucier Chairman and CEO, Life Technologies June 13, 2013
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2 | Life Technologies™ Proprietary and Confidential 6/18/13
Main Frame Mini Computer Personal Computer
CE/Sanger Sequencing Next-‐Gen Sequencing Ion Semiconductor Sequencing
Requirements for Success 1) Scalable, Affordable Technologies, 2) Simple and Complete Workflows,
3) Rapid Turnaround Times, 4) Strong Support – Community and Field Support
Ultimate Goal: Making High Throughput Sequencing Accessible to All
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3 | Life Technologies™ Proprietary and Confidential 6/18/13
Million Dollar Genome
$1,000 Genome
40 Years of Accumulated Moore’s Law
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4 | Life Technologies™ Proprietary and Confidential 6/18/13
Semiconductor Scalability Has Strong Historical Precedent
1975 1st Digital Camera (Kodak)
0.01 Megapixel $15,000
1979 Intel 8088
29,000 Transistors $125
Today Intel® Ivy Bridge Core i7
1.4 Billion Transistors $325
Today iSight Camera (iPhone 5, Apple)
8 Megapixel $199
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5 | Life Technologies™ Proprietary and Confidential 6/18/13
Semiconductor economies of scale
Electronic detection
Unmodified nucleotides
Low-cost, fast, small form factors
Semiconductor Affordability
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6 | Life Technologies™ Proprietary and Confidential 6/18/13
Movement in the Industry
§ Decreasing grant monies to government and academic labs § Consolidation of pharmaceutical and biotechnology industries § Tens of thousands of people have had all or some part of their
genome sequenced − 1000 Genome Project recently completed sequencing at low
coverage 2,534 individuals form 26 populations around the world § Industry leaders:
− Roche hostile takeover bid of Illumina − Life Technologies being acquired by Thermo Fisher − Illumina cutting ties with Oxford Nanopore - termination of
commercial agreement in 2016 − Roche terminating agreements with DNAe (semiconductor-based
sequencer) and IBM (nanopore-based sequencer)
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7 | Life Technologies™ Proprietary and Confidential 6/18/13
Living in a DNA Economy § Federal investment in the human genome sequencing
projects directly and indirectly generated: − $965 billion in economic activity − More than 53,000 direct genomics-related jobs − $293 billion in personal income.
The 24-year U.S. investment in genomics amounts to $2/
year for each U.S. resident, generating nearly $1 trillion in cumulative economic impact to date
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8 | Life Technologies™ Proprietary and Confidential 6/18/13
Barriers to Continued Growth
§ Policy − Regulatory and reimbursement systems need to catch up and pay
for the value they can help create
§ Practice − Doctors need to integrate genomics more fully into their practice
of medicine − Informatics presented in a user friendly, impactful format − Lack of data sharing
§ Funding − Genomics technology industry is very U.S. dominated - in large
part because of strong partnership between the government and industry
− Use of genomics, however, will become a race to lead the next phase of the genomics revolution
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9 | Life Technologies™ Proprietary and Confidential 6/18/13
Personalized Oncology: Applying Cancer Genomics and Informatics
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10 | Life Technologies™ Proprietary and Confidential 6/18/13
Next-Generation Sequencing: Beyond Healthcare Research
Fuel
Enzymes
Health
Bio Chemicals
Food
Reading DNA Writing DNA
Genetically ID’ed suspect
Police sketch is not enough
+ = Positive ID
Human Identification