science market regulation ubic - semantic scholar · 2018-03-01 · in milk, lactoperoxidase is one...

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THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET

2 0 1 5

350 pages

This comprehensive report is based on in-depth interviews with food companies completed by a desk review.

It provides for DECISION MAKERS a global understanding of the sector as well as an outlook on its future.

SCIENCE – MARKET – REGULATION - MANUFATURERS

New trends and perspectives Use of ingredients: volumes-valueManufacturers profilesUser’s opinionRegulation

North AmericaWestern and Eastern EuropeAsiaAustralia- New Zealand

Food industryCosmeticsPharmacyIndustrial markets

LactoferrinLactoperoxidase

MARKET ANALYSIS

INGREDIENTS

FOOD SEGMENTS

COUNTRIES COVERED

350 pages

O B J E C T I V E S

M A R K E T

Industrial users needs,

expectations and volumes

Applications in segments

and consumption trends

Consumer market trends by

food segments

Prospective and forecast

M A N U F A T U R E R S

Processes and capacities

Market share

Company description

R E S E A R C H

New researches and

developments

New applications

SCIENCE – MARKET – REGULATION - MANUFATURERS

O B J E C T I V E S

M A R K E T






food segments




Market share

Company description

R E S E A R C H

New researches and

developments

New applications

It is now over 40 years since lactoferrin was

first isolated. Lactoferrin, which belongs to the

transferring family of proteins, is a 70-80 kDa

single sub-unit glycoprotein and consist of two

domains, each with one iron-binding site that

requires synergistic binding of a bicarbonate

anion. A conformational change in the binding

site, between open or closed forms, accompanies

iron binding and release. The affinity of

lactoferrin for iron is much greater than of

transferrin which functions as an iron carrier in

serum. In the “natural state”, lactoferrin is only

partly saturated with iron (5-30%) and has a

salmon color, the intensity of which depends on

the degree of iron saturation.

It is present in human milk, and many exocrine

fluids (saliva, mucous secretion) as well as

mammalian.

INTRODUCTION


Lactoferrin concentration in different sources

Bovine milk 200 mg/l

Bovine colostrum 1g/l

Human milk 2-4 g/l

Human colostrum 6-8 g/l

Bovine LF and human LF have approximately

69% of similarities in amino acid residues.

Human milk is the most abundant source of LF. It

is one of the major whey proteins in human milk

with concentrations of 1.4–2.0 mg mL-1 but only

a minor component in bovine milk with only one

tenth (0.1–0.2 mg mL-1) of concentration found

in human milk.

Lactoperoxidase is a hemoprotein that

catalyzes the oxidation of thyocyanate and iodide

ions in the presence of hydrogen peroxide to

produce highly reactive oxidizing agents. These

products have a broad spectrum of antimicrobial

effects. They can kill viruses, gram positive and

gram negative bacteria, fungi, and probably also

mycoplasmas and parasites.

This enzyme is primarily found in such exocrine

secretions as saliva, lachrymal fluid and milk,

cervical mucous and nasal glands. Human milk

does not appear to contain lactoperoxidase

(Tenovuo, 1985). However, a more recent study

confirmed the presence of lactoperoxidase in

human colostrum.

In milk, lactoperoxidase is one of the non

immunoglobulin protective proteins and its

antibacterial activity in raw milk was suggested

as early as 1924.

Bovine milk contains about 20 times higher LP

than that of human milk (Gothefors and

Marklund 1975) and it is the second most

abundant enzyme (De Wit and Van Hooydonk

1996) in bovine milk.

Milk

Water

Minerals

Lactose

Proteins

Whey

Whey Protein Concentrate

Immunoglobulin

Alpha-Lactalbumine

Beta - Lactalglobuline

Bovine Serum

Albumin

Lactoferrin

Lactoperoxidase

Peptides

Whey Protein Isolate

Delactosed & Demineralized

whey

Caseins

Phosphocaseinates

Rennet Casein

Ionic Casein Caseinates

Lactic Casein

O B J E C T I V E S

M A R K E T






food segments




Market share

Company description

R E S E A R C H

New researches and

developments

New applications


O B J E C T I V E S

M A R K E T






food segments




Market share

Company description

R E S E A R C H

New researches and

developments

New applications

FUNCTIONALITIES


In many ways, lactoferrin has been an easy

protein to investigate; however, there have been

difficulties understanding specific

structure/function relationships, particularly as it

functions in vivo;

Heat stability: At low ionic strength and/or low

pH, the resistance of lactoferrin to heat

denaturation is good and methods for heats

treatment and pasteurization have been

published.

Iron bioavailability: Two features of the

functional properties of lactoferrin are its ability

to bind iron exceptionally tightly and the coupling

of rigid-body domain movements to iron bindings

and release.

Anticarcinogenic effect: Lactoferrin has been

reported to inhibit cancer growth by inducing

apoptosis and stimulating the production of

critical cytokines, such as IL-18 etc.

Antimicrobial agent: Its capacity to bind iron

and to stay bound with iron until pH 3 interfer in

the proliferation of pathogen bacteria.

Antiviral agent: Recently, Antiviral activity has

been described as well for herpes, cytomegalo

and influenzes virus.

Inflammatory and Immune response:

Lactoferrin has various effects on the immune

system, such as regulation of antibody

production, complement activation, and natural

killer cell function.

Anti-oxidant effect: Lactoferrin scavenges

excess iron thereby protects the host to

peroxidation reactions.

� Lactoperoxidase can be combined to

lactoferrin in protection of the mucosal surface

and prevention of tooth decays.

Lactoperoxidase could elicit with bacteriostatic

and/or bactericidal activity on a variety of

susceptible microorganisms including bacteria,

fungi and viruses. The molecular mechanism (s)

of such inhibitory effects depend on the type of

electron donor, test media, temperature and pH

and could range from oxidative killing to

blockage of glycolytic pathways or interference

in cytopathic effects;

Antibacterial Effect: Gram-negative, catalase-

positive organisms, such as pseudomonas,

coliforms, salmonellae and shigellae, are not

only inhibited by the lactoperoxidase system

(LPS) but also, depending on the medium

conditions (pH, temperature, incubation time,

and cell density) may be killed. Gram-positive,

catalase negative bacteria, such as streptococci

and lactobacilli are generally inhibited but not

killed by the LPS.

Antifungal Effect: Seifu et al. declared that LPS

in goat milk inhibit growth and proliferation of

many fungal species viz., Aspergillus flavus,

Penicillium chrysogenum, Trichoderma spp.,

Alternaria spp. and Claviceps spp., Corynespora

cassicola, Phytophthora meadii and Corticium

salmonicolor; however, Candida albicans and

Pythium spp. were not affected by the this

system.

Antiviral Effect: Shin et al. reported the

potential of oral administration of LPS to

attenuate pneumonia in influenza-virus-infected

mice through the suppression of infiltration of

inflammatory cells in the lung.

O B J E C T I V E S

M A R K E T






food segments




Market share

Company description

R E S E A R C H

New researches and

developments

New applications


Based on the physiological, biological and

functional properties attributed to lactoferrin

and lactoperoxidase, there are a number of

interesting and innovative possibilities for

the application of these bio-active proteins

extracted from bovine milk.

APPLICATION RANGE

Functionality Food products

Infant formula

Sports and functional food

Pharmaceuticals Veterinary and feed

specialties

Personal care products

Lact

ofer

rin

Iron absorption � � �

�

Anti-inflammatory

� � �

Intestinal flora protection

� � � � �

Antibacterial � � �

Immune cell stimulation

� � � �

Antioxidant � � �

Lact

oper

oxid

ase Antimicrobial � � �

Anti-inflammatory in guts

� �

Intestinal flora protection

� � � �

Some of the applications are related to the

natural presence of lactoferrin and

lactoperoxidase in the human secretions: milk,

saliva, tears.

The following table will describe the potential

applications of lactoferrin and lactoperoxidase.

O B J E C T I V E S

M A R K E T






food segments




Market share

Company description

R E S E A R C H

New researches and

developments

New applications

OUTLOOK OF THE MARKET


There is a high level of competition with certainlarge companies that have worked on lactoferrinand lactoperoxidase for more than 20 years.

Lactoferrin has present applications in the dietetic field (food or OTC drug) and more anecdotically oral hygiene and in animal care nutrition.

Lactoferrin Market in tons

Segment 1997 2001 2007 2008 2011 2012

FOOD & NUTRITION

• Infant formula• Food

supplements• Dairy products• Others (meat,

etc)PHARMACEUTICALS

• Iron tablets• Immune system

stimulation• Health of

intestinal floraCOSMETICs and HYGIENE• skin care• body care• Oral hygieneOTHERSTOTAL


Lactoferrin Market Forecast in tonsSegment 2011 2012 2013 2014 2015

Infant Formula

Food & Nutrition

• Food Supplements

• Dairy Products

• Others (Meat, etc.)

Pharmaceuticals

Cosmetics & Hygiene

Others

Total

TABLE OF CONTENT


Methodology 10SUMMARY AND CONCLUSIONS 12Highlights 12Potential Market 13Price 14Competition 17Strategy and key success factors 18Lactoferrin and Lactoperoxidase Use: The Present Market 22Research Trends 23Communication towards the Consumers 24Frequently Asked Questions by the Industrial Users 24INTRODUCTION 30Lactoferrin and Lactoperoxidase: Two Bioactive Milk Proteins 30FUNCTIONALITIES 31LACTOFERRIN 31Heat stability 31Iron bioavailability 31Iron uptake from lactoferrin 32Cell proliferation 32Antimicrobial agent 32Antiviral agent 33Inflammatory and Immune response 33Anticancer activity 33Anti-oxidant effect 34Interaction of Lactoferrin with other molecules 34Receptor binding properties 34LACTOPEROXIDASE 35Microbiological Effect of the Lactoperoxidase 36Application of LPS in Food Industry 37Future Trends 38TRENDS OF RESEARCH 39PRODUCT POSITIONING 40PRODUCT RANGE 40Milk Proteins 40Competitive Products 41

Products involved in iron and calcium transport and absorption 41Casein phosphopeptide 41Ovotransferrin 42Iron salts 42Lactoperoxidase 42Lysozyme 42Other natural antibacterial agents 42APPLICATION RANGE 43LEGAL STATUS 44COMMUNICATION ABOUT THE PRODUCT 45PRICE 46SPECIFICATIONS 47EXTRACTING LACTOFERRIN 47FUTURE TRENDS 48COMPETITION 49PLAYERS AND THEIR STRATEGIES 49Producers 49ARMOR PROTÉINES SAS (FR) 51AGENNIX INC (US) 52AGRI MARK INC (US) 54FRIESLAND CAMPINA NV (NL) 56DSM FOOD SPECIALTIES BV (NL) 61ERIE FOODS INT’L INC (US) / MURRAY GOULBURN CO LTD (AU) 62FONTERRA CO-OPERATIVE GROUP LTD (NZ) 63GLANBIA NUTRITIONALS INC (US) / GLANBIA PLC (IE) 67INGREDIA SA – (FR) 70MILEI GMBH (DE) 73MORINAGA MILK INDUSTRY CO LTD (JP) 76MURRAY GOULBURN CO-OPERATIVE CO LTD (AU) 79PHARMING GROUP NV (NL) 81SYNLAIT (NZ) 85TARADON LABORATORY SPRL (BE) 88TATUA CO-OPERATIVE DAIRY CO LTD (NZ) 91TATURA MILK INDUSTRIES LTD (AU) 93VENTRIA BIOSCIENCE INC (US) 95

TABLE OF CONTENT


VITALUS NUTRITION INC (US) 96WESTLAND CO-OPERATIVE DAIRY CO LTD (NZ) 98WARRNAMBOOL CHEESE & BUTTER FACTORY CO.LTD (AUS) 101Industrial Production and Technologies 102Bovine lactoferrin and lactoperoxidase 102Human Lactoferrin 106Use of transgenic animal 106Fermentation using the fungus Aspergillus 106Patented Processes 107Process cost 107Processes description 109PROTECTED APPLICATIONS 110TRENDS 114MARKET ANALYSIS 115Lactoferrin Market 115Leading Applications 116Lactoferrin market by Application 119Lactoferrin market by Region 122Main suppliers of Lactoferrin 123LACTOFERRIN IMPORT CHINA 127FOOD APPLICATIONS 128Health food: Definition and Regulation 128General trends on the Health food markets 137Analysis by health food segments 141Infant Nutrition 142Regular Nutritional Food 152Nutritional drinks 152Mineral fortified food 155Functional Food 156Food Supplements 157Women's nutrition 161Senior diet 161Children diet 162Sport nutrition 162Weight management 164

Feed 165Preservatives in Food Products 166Trends on the market 166Perspective for lactoferrin and lactoperoxidase 166Company Advice and Profile 167ABBOTT LABORATORIES INC (US) 167ASHLAND INC (US) 170AVANTE INTERNATIONAL LTD (NZ) 172ZHEJIANG BEINGMATE SCIENTIFIC INDUSTRIAL TRADE SHARE CO LTD (CN) 174DICOFARM SPA (IT) 177GROUPE DANONE (NL) 178EAGLE ELECTRIC (Shenzhen) Co., Ltd (CH) 180GUANGDONG YASHILI GROUP CO LTD (CN) 181HEILONGJIANG YAOLAN DAIRY PRODUCTS STOCKS Co., Ltd (CN) 183HANS CORP CO LTD (KR) 185HOCHDORF NUTRICARE (CH) 188JIANGXI MEILU DAIRY CP LTD (CN) 189ANONYOUS CORPORATION (JP) 192WEIDER NUTRITION INTERNATIONAL INC (US) 194MAEL DAIRY INDUSTRY (KR) 196MEAD JOHNSON NUTRITION / MEAD JOHNSON & COMPANY LLC (US) 197MEIJI MILK PRODUCTS CO LTD (JP) 199MEGMILK SNOW BRAND CO LTD (JP) 201MORINAGA MILK INDUSTRY CO LTD (JP) 205MURRAY GOULBURN CO-OPERATIVE CO LTD (AUS) 208NESTLÉ SA (CH) 210NAMYANG DAIRY PRODUCTS CO LTD (KR) 212DANONE NUTRICIA ADVANCED MEDICAL NUTRITION (NL) 213NUTRIDAR PLC (JO) 214SEOUL DAIRY COOPERATUVE/ SEOUL MILK CO LTD (KR) 216OTSUKA PHARMACEUTICAL CO LTD (JP) 218LABORATORIOS ORDESA SL (SP) 219PT SARI HUSADA (INDONESIA) / GROUDE DANONE (FR) 222QUAKER (US) 224NESTLÉ PURINA PETCARE COMPANY (US) / NESTLÉ SA (CH) 226

TABLE OF CONTENT


REBORNNE NEW ZEALAND LTD (NZ) 227SCHIFF NUTRITION INTERNATIONAL INC (US) 228SHANGAI BRIGHT (GUANGMING) DAIRY & FOOD CO LTD (CN) 229SODIAAL SA (FR) 231SUNTORY HOLDINGS LTD (JP) 233UNITED DAIRY GROUP LTD (CN) 234WAKODO CO LTD (JP) 237INNER MONGOLIA YILI INDUSTRIAL GROUP CO LTD (CN) 238YABAIS DAIRY PRODUCTS CO LTD (AU) 240ZIM LABORATORIES LTD (IN) 244PHARMACEUTICAL APPLICATIONS 245Trends on the market 245Pharmaceutical drugs market 245Over the counter drugs market 245Cosmetic market 249Perspectives for lactoferrin and lactoperoxidase 251Immune system support 251Anti-infective 251Gastro-intestinal tract 251Ophtalmic products 252Anti-cancer therapeutic agent 252Product conservation 252Skin Health 253Anti-oxydant activity 253Lactoferrin Contraindications, Interactions & Precautions 254Company advices 255ALCON LABORATORIES (NOVARTIS GROUP-FR) 255BAUSCH & LOMB (US) 256PFIZER (ex JOUVEINAL - FR) 257LACLED INC (US) 258MERCK & CO (US) 260METAGENICS INC (US) 261MP BIOMEDICALS (US) 263NRL PHARMA INC (JP) 265OENOBIOL LABORATORIES (FR) 269

PIERRE FABRE SA (FR) 270PROHEALTH INC (CA) 271SYMBIOTICS INC / NATURADE INC (US) 274SOVEREIGN LABORATORIES INC (US) 275GROUPE GTF (FR) 278XIGO HEALTH LLC (US) 279ZENDIUM / UNILIVER NV (NL) 280ZIM LABORATORIES LTD (IN) 282LOVELY HEALTH LTD (NZ) 283FIT-BIOCEUTICALS LTD (AU) 284VIDA NUTRISCIENCE INC (PH) 286LIFE EXTENSION INC (US) 287GENOSCOPE SPZOO (PL) 288ANNEXES 289US PATENT 290Lactoferrin 290Lactoperoxidase 302REGULATION 319CFSAN/Office of Premarket Approval 319Data and information that DMV International presents to support its GRAS determination 319FDA's evaluation of the data and information in DMV International's notice 320Conclusions 321CFSAN/Office of Food Additive Safety 322REGULATION– NOVEL FOOD PETITION 325SPECIFICATIONS 329STUDIES 332CHINESE IMPORTATIONS OF LACTOFERRIN – LIST OF USERS / JAN-DEC 2012 336

LIST OF TABLES


Table 1 Lactoferrin market in tons estimations and forecast 1997-2015 12Table 2 Consumption of Lactoferrin by market segment 13Table 3 Lactoferrin potential market segment and main products 14Table 4 Present market of Lactoferrin market 22Table 5 Present market of Lactoperoxidase 23Table 6 Potentialities of Lactoferrin in Food Products 25Table 7 In OTC and Semi-ethical Drugs 26Table 8 In cosmetic and oral hygiene products 27Table 9 Potentialities of Lactoperoxidase In food products 28Table 10 In cosmetic and oral hygiene products 29Table 11 In OTC and semi-ethical drugs 29Table 12 Interaction of Other Molecules and Lactoferrin 34Table 13 Nutritional/biological function in Milk protein and Bioactive 40Table 14 Potential Application in Lactoferrin and Lactoperoxidase 43Table 15 Main suppliers of Lactoferrin 50Table 16 Extraction methods performed by different companies 105Table 17 Patented process in Lactoferrin Manufactures 107Table 18 Patented Lactoferrin Based Products and Applications 110Table 19 Patented Lactoperoxidase Based Products and Applications 113Table 20 Examples of LF application available in Japan 116Table 21 Lactoferrin market in tons estimations and forecast 1997-2015 118Table 22 Lactoferrin market Forecast in Infant Formula 2011-2015 (tons) 119Table 23 Lactoferrin market Forecast in Foods 2011-2015 (tons) 119Table 24 Lactoferrin market Forecast in Pharmaceuticals 2011-2015 (tons) 120Table 25 Lactoferrin market Forecast in Hygiene 2011-2015 (tons) 121Table 26 Consumption of Lactoferrin by market segment (ton) – 2014 122Table 27: Lactoferrin Import China 2012 127Table 28 Approved FDA health claims in specific cases (food and nutrition) 135Table 29 Nutraceuticals market in Japan (2011) 137Table 30 Health foods Category in Japan (2011) 138

Table 31 Global users of Lactoferrin in Infant Formula (2012) 149Table 32 Japanese users of Lactoferrin in Infant milk and formula milk (2013)151Table 33 Comparisons of Main Nutritional Formulas 153Table 34 Sales of Leading Functional Drinks in Japan 154Table 35 Other using segments for Lactoferrin - Functional Food 156Table 36 Ingredient nutrition example of Lactoferrin tablet in USA 157Table 37 Other using segments for Lactoferrin- Food Supplements 158Table 38 Other using segments for Lactoferrin 165Table 39 New Food Biopreservatives 166Table 40 OTC main categories in USA 247Table 41 Other using segments for Lactoferrin - Cosmetic 250Table 42 US PATENT of Lactoferrin 290Table 43 US PATENT of Lactoperoxidase 302

LIST OF FIGURES


Figure 1 Most Promising Segments of Development for Lactoferrin 16Figure 2 the World Lactoferrin Market by Shares of Producers (2015) 17Figure 3 Strategic Issues for Lactoferrin and Lactoperoxidase 20Figure 4 Strategic recommendations for using Lactoferrin 21Figure 5 Relative added value pyramid for protein derived from whey 46Figure 6 General extraction methods of Lactoferrin and Lactoperoxidase 102Figure 7: Lactoferrin’ global Market volume estimations (2007-2017) 115Figure 8: Lactoferrin market breakdown by application 2014 117Figure 9 Lactoferrin market Forecast in FOOD & NUTRITION (2015) 119Figure 10 Lactoferrin market Forecast in Pharmaceuticals (2015) 120Figure 11 Lactoferrin market Forecast in Pharmaceuticals (2015) 121Figure 12: Lactoferrin market breakdown by application 2014 121Figure 13: Lactoferrin market consumption by geographical area 2014 122Figure 14: Lactoferrin Import in China in volume by month 2012 127Figure 15: Country of origin of Lactoferrin imported (in kg) in China 2012 127Figure 16: Chinese Import of Lactoferrin from the EU - 2012 128Figure 17 Schematic Circuits for a Novel Food Dossier 130Figure 18 Schematic Circuits for a New Additive Dossier 131Figure 19. Health Foods without FOSHU (billion Yen) 1988-2011 137Figure 20. Market Scale of FOSHU in Japan (billion Yen) 1997-2011 138Figure 21. Annual trends in Number of Items of FOSHU (1993-2012) 139Figure 22. Percentage of the Products by Health Claim FOSHU (2011) 139Figure 23 History of Infant Formula’s product and modification 143Figure 24: Share Individual OTC market in Europe 247Figure 25: OTC Drug market size in Japan 2004-2013 248

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science market regulation ubic - semantic scholar · 2018-03-01 · in milk, lactoperoxidase is one...

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