COLLEGE OF PHARMACY

REPORTSCHOLARSHIPRESEARCH &

JULY 1ST 2013 – JUNE 3OTH 2014

Microscope images showing localization of connexins and connexin mutants that cause cataracts.

J.J. Tong, B.C. Sohn, A. Lam, D.E. Walters, B.M. Vertel, L. Ebihara, “Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46,” Amer. J. Physiol. 304:C823-32 (2013).

Introduction

This is the second annual College of Pharmacy Research and Scholarship Report,

covering the academic year, July 1, 2013 – June 30, 2014. It is truly a pleasure

for me to compile the research and scholarship accomplishments of the faculty and

students of our College. The report includes peer reviewed publications, books,

presentations at local, national and international meetings, invited seminars, and

grant-funded research projects. I am certain you will be impressed with the research

and scholarship output of our College.

D. Eric Walters, Ph.D.

Associate Dean for Research

A.M. Casapao, S.L. Davis, Viktorija O. Barr, K.P. Klinker, D.A. Goff, K.E. Barber, K.S. Kaye, R.P. Mynatt, L.M. Molloy, J.M. Pogue, and M.J. Rybak. Large retrospective evaluation of the effectiveness and safety of ceftaroline fosamil therapy. Antimicrob. Agents Chemother. 2014, 58(5):2541-2546.

C. Cocchio, A.-J. Geib, and Kevin O. Rynn. Physiochemical Stability of Intravenous Fat Emulsion in Combination with Medications Used for Resuscitation. SOJ Pharm. Pharm. Sci. 2014, 1(1):3.

S.L. Foster, C.T. Short, and Lauren B. Angelo. Vaccination of patients with altered immunocompetence. J. Amer. Pharm. Assoc. 2013, 53(4):438-40.

A.K. Ghosh, G.E. Schilz, L.N. Rusere, H.L. Osswald, D. Eric Walters, M. Amano, and H. Mitsuya. Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands. Org. & Biomol. Chem. 2014, 12:6842-6854.

Megan E. Hartranft and R.E. Regal. “Triple Phase” Budesonide Capsules for the Treatment of Olmesartan-Induced Enteropathy. Ann. Pharmacother. 2014, 48(9):1234-1237.

Sean P. Kane, A.P. Bress, and E.P. Tesoro. Author response to Brown et al characterization of free phenytoin concentrations in neurointensive care unit patients using a revised Winter-Tozer equation. Ann. Pharmacother. 2013, 47(12):1744.

Abbie E. Lyden, C. Cooper, and E. Park. Beta-Blocker Overdose Treated with Extended Duration High Dose Insulin Therapy. J. Pharmacol. Clin. Toxicol. 2014, 2(1):1015.

Ann Opalka (Livorsi), K. Look, and A. Margolis. Statistics Review Part 3: Standard Deviations and Confidence Intervals. The Journal. Pharm. Soc. Wisconsin. 2014, January/February:48-49.

T.S. Patel, R.D. Crutchley, A.M. Tucker, Jessica M. Cottreau, and K.W. Garey. Crofelemer for the treatment of chronic diarrhea in patients living with HIV/AIDS. HIV/AIDS (Auckl). 2013, 5:153-162.

K. Phe, Y. Lee, P.M. McDaneld, N. Prasad, T. Yin, D.A. Figueroa, W.L. Musick, Jessica M. Cottreau, M. Hu, and V.H. Tam. In vitro assessment and multicenter cohort study of comparative nephrotoxicity rates associated with colistimethate versus polymyxin B therapy. Antimicrob. Agents Chemother. 2014, 58(5):2740-2746.

J.M. Pogue, R.P. Mynatt, D. Marchaim, J.J. Zhao, Viktorija O. Barr, J. Moshos, B. Sunkara, T. Chopra, S. Chidurala, and K.S. Kaye. Automated alerts coupled with antimicrobial stewardship intervention lead to decreases in length of stay in patients with gram-negative bacteremia. Infect. Control Hosp. Epidemiol. 2014, 35(2):132-138.

Michael D. Shuman and I.R. McGrane. Rationale for use of iloperidone in treatment of post-traumatic stress disorder. Innov Clin Neurosci. 2014, 11(5-6):23-25.

Michael D. Shuman, E. Trigoboff, T.L. Demler, and L.A. Opler. Exploring the potential effect of polypharmacy on the hematologic profiles of clozapine patients. J. Psychiatric Practice. 2014, 20(1):50-58.

Janeen Winnike. Set A Strong Foundation For Your Summer. Student Pharmacist. 2014, 10(5):May 2014.

Peer Reviewed and

Professional Publications

L.B. Angelo and J. Cerulli. How to Conduct a Comprehensive Medication Review: A Guidebook for Pharmacists. Washington, DC: American Pharmacists Association. 2014.

L.B. Angelo and W.A. Miller. Postgraduate Year 1 Community Pharmacy Residency Program Implementation Guide. Washington, DC: American Pharmacists Association. 2014.

D. Eric Walters. Can Diet Soft Drinks Make You Fat?. Medscape, http://www.medscape.com/viewarticle/810738, 2013.

Books, Book Chapters

and Other Publications

Najeah Ahmad and D. Eric Walters. SERCA and Alzheimer’s Disease. Summer Research Poster Session, RFUMS, October, 2013.

Lauren B. Angelo. 2014 Immunization Update for Pharmacists. CPE Presentation. North Suburban Pharmacists Association Meeting. February 2014.

Lauren B. Angelo. Delivering Medication Therapy Management Services. Thrifty White Pharmacy, Fargo, ND. May 2014.

Lauren B. Angelo. Pharmacy-Based Immunization Delivery. Sam’s Club, Las Vegas, NV, July 2013; Walgreens, Detroit, MI, August, 2013; University of South Florida, Tampa, FL, November 2013; American Pharmacists Associaton, Austin, TX, November 2013; H.D. Smith, Dearborn, MI, May 2014.

Lauren B. Angelo. When the Pharmacy Becomes a Laboratory: Guidance for Point-of-Care Testing. CPE Presentation. Illinois Pharmacists Association 2013 Annual Conference. September 2013.

J. Becker and Sarah S. Garber. Tools for Teaching Physiology Interprofessionally. American Physiological Society, Bar Harbour, ME. June 2014.

Brian Bogdanowicz, K. Bajer, Abbie E. Lyden, Kevin O. Rynn, et al. The Effect of Migraine Pharmacotherapy on Patient Stay in the Emergency Department. Summer Research Poster Session, RFUMS. October 2013.

Edrian Calago and Sean Kane. Pre-hospital ß-blocker use evaluated in septic shock patients in the Intensive Care Unit. Summer Research Poster Session, RFUMS, October, 2013; All School Research Symposium, RFUMS, March 2014.

A.M. Casapao, S.L. Davis, Viktorija O. Barr, K.P. Klinker, D.A. Goff, K.E. Barber, L.M. Steinke, R.P. Mynatt, K.S. Kaye, J.M. Pogue, and M.J. Rybak. Multicenter Experience of the Effectiveness and Safety with Ceftaroline Fosamil (CPT) Therapy. Interscience Conference on Antimicrobial Agents and Chemotherapy, Denver, CO, September 2013.

A. Clemmons, Megan Hartranft, V. Kota, J. Pantin, F. Awan, H. Salman, and A. Jillela. Administration of Rabbit Anti-Thymocyte Globulin: Slowing Infusion Rate over a 4 Day Course with Aggressive Use of Pre-Medications May Decrease ATG Related Infusion Reactions. BMT Tandem Meeting. Grapevine, TX. March 2014.

D. DeRemer, S. Clar, and Megan Hartranft. Trending Now #ExcellenceInPrecepting: Effective Ways to Incorporate Social Media into Clinical Practice. National Pharmacy Preceptors Conference. Washington DC. August 2013.

G. Dimitrievski, W. Palecek, K. Levasseur-Franklin, and Abbie E. Lyden. Pharmacists’ Role in Emergency Airway Responses. American Society of Health-System Pharmacists Midyear, Orlando, FL. December 2013.

Sarah S. Garber. A Culture of Interprofessional Education: highlights, challenges & lessons learned. Keynote Speaker, University Retreat for Marshall B. Ketchum University. February 2014.

Megan Hartranft. Integrating Social Media into Clinical Practice. South Carolina Society of Health-System Pharmacists Fall Meeting. Columbia, SC. October 2013.

Megan Hartranft. Integrating Social Media into Clinical Practice. Georgia Society of Health-System Pharmacists Fall Meeting. Young Harris, GA. October 2013.

Abstracts, Presentations

and Invited Seminars

Viktorija O. Barr, K.P. Klinker, D.A. Goff, K.E. Barber, L.M. Steinke, R.P. Mynatt, K.S. Kaye, J.M. Pogue, and M.J. Rybak. Multicenter Experience of the Effectiveness and Safety with Ceftaroline Fosamil (CPT) Therapy. Interscience

Megan Hartranft, A. Clemmons, and D. DeRemer. Evaluation of romiplostim for secondary failure of platelet recovery in allogeneic hematopoietic stem cell transplant patients. UHC Resident Poster Session. Orlando, FL. December 2013.

Megan Hartranft, D. DeRemer, B. Phillips, and R. Kohle. Differential DNA methylation patterns in acute myeloid leukemia patients with obesity. HOPA Annual Meeting. New Orleans, LA. March 2014.

Kevin Mahler and David H.T. Harrison. Expression and Purification of Recombinant Caspase-1. Summer Research Poster Session, RFUMS, October, 2013.

L.J. Mast, D. Bridges, Ateequr Rahman, and N. Horsley. Continuing Professional Education: The Key to Building Interprofessional Teams. TEACHING PREVENTION 2013, Association for Prevention and Teaching Research (APTR). Washington , DC. March 2013.

L.J. Mast, D. Bridges, Ateequr Rahman, and N. Horsley. Continuing Professional Education: The Key to Building Interprofessional Teams to Develop Preventive Care Models. Collaboration Across Borders (CAB IV). Vancouver, BC, Canada. June 2013.

TrieJaye McDowell, Andrew Ruettiger, et al. SERCA Compounds. Summer Research Poster Session, RFUMS, October, 2013.

Amy McGlin and D. Eric Walters. Plasma Membrane Citrate Transporter. Summer Research Poster Session, RFUMS, October, 2013.

Gloria E. Meredith. Business Skills for the 21st century Pharmacist. BigY Foods annual convention, Springfield MA. April 2014.

Lisa Michener. Development of a Longitudinal Professionalism Tracking Method. E*Value User Conference, Minneapolis, MN. October 2013.

Lisa Michener. Introductory Collaborative Learning Bridge (ICLB) A Curricular Innovation. American Assn. of Colleges of Pharmacy Annual Meeting, Chicago, IL. July 2013.

N. Olson, D. Hirsch, Abbie E. Lyden, et al. Creating a Novel Pharmacy Curriculum for Emergency Medicine Resident Physicians. CORD Academic Assembly Advances in Education Research and Innovations Forum. March 2014.

Ann Opalka (Livorsi). Evaluation of an interdisciplinary approach to addressing female Veterans with elevated low-density lipoprotein cholesterol. Great Lakes Pharmacy Resident Conference, West Lafayette, IN. April 2014.

Ann Opalka (Livorsi) and S. Schumacher. Menopause: VA SCAN-ECHO. Presented to various VA Hospitals within VISN-12 network; Madison, WI. March 2014.

Ann Opalka (Livorsi). Veterans With Dysphagia: Assessment and Treatment For Fracture Risk. American Society of Health-System Pharmacists (ASHP) Midyear Clinical Meeting, Orlando, FL. December 2013.

Ann Opalka (Livorsi). Veterans With Dysphagia: Assessment and Treatment For Fracture Risk. Pharmacy Society of Wisconsin Annual Meeting, Green Bay, WI. September 2013.

Amanda Outinen and Gloria E. Meredith. Tyrosine-hydroxylase Expressing Neurons in the Striatum of Parkinsonian Rat Models. Summer Research Poster Session, RFUMS, October, 2013; All School Research Symposium, RFUMS. March 2014.

O.A. Phillips, R. D’Silva, D. Eric Walters, L. Sharaf, Teklu O. Bahta, E. Udo, and L. Benov. Synthesis and biological evaluation of novel oxazolidinone hydroxamic acid derivatives. 19th Health Sciences Centre Poster Conference, Kuwait University, May 6-8, 2014.

Monal Punjabi. Development of a Clinical Severity Score in Congenital Muscular Dystrophy. Oral presentation, All School Research Symposium, RFUMS. March 2014.

Monal Punjabi, C. Vuillerot, M. Leach, J. Collins, R. Butterfield, M. Linton, I. Arveson, S. Donkervoort, J. Dastgir, M. Jain, E. Kim, C. Bonnemann, A. Rutkowski and K Meilleur. Poster, All School Research Symposium, RFUMS. March 2014.

Ateequr Rahman. Interprofessional Heath care interventions in a care coach Model. Annual Business and Health Administration Association Conference, Chicago. March, 2014.

Shiva Shirvanifar and Rahul Deshmukh. Relevance of Protein Binding in Age- Dependent Pharmacokinetics of Micafungin. Summer Research Poster Session, RFUMS. October, 2013.

Michael D. Shuman, R. Hieber, L. Moss, and D.J. Patel. Rivaroxaban for thromboprophylaxis in patients receiving electroconvulsive therapy. Annual Meeting of the College of Psychiatric and Neurologic Pharmacists, Phoenix, AZ. April 2014.

Carrie Spindler and Sean Kane. Impact of hydrocortisone on atrial fibrillation in septic shock. Summer Research Poster Session, RFUMS, October, 2013; All School Research Symposium, RFUMS. March 2014.

Aditi Thakkar, Alisa Joseph, and Kristy Shanahan. Assessing Health Care Educator Compliance With The Bloodborne Pathogen Standards. Summer Research Poster Session, October, 2013.

M. Vertin, E. Zdyb, Abbie E. Lyden, et al. Antibiotic Selection in Febrile Neutropenic Patients in the Emergency Department. Great Lakes Pharmacy Resident Conference, May, 2014.

D. Eric Walters. What Every Pharmacist Should Know About Sweeteners. American Assn of Colleges of Pharmacy, Annual Meeting, Chicago, IL, July 13-17, 2013.

D. Eric Walters. Sweet Taste Receptors: How and Where Signaling Happens. Institute of Food Technologists, Annual Meeting, Chicago, IL, July 13-16, 2013.

D. Eric Walters. Sweet Taste Mechanisms and the History of Sweetener Blends. Institute of Food Technologists, Annual Meeting, Chicago, IL, July 13-16, 2013.

D. Eric Walters. The Computational Chemistry Toolbox: Selected Tools and Selected Applications. Rock River Section, American Chemical Society, Rockford, IL, September 2013.

D. Eric Walters. Design of New HIV Protease Inhibitors to Combat Viral Resistance. Benedictine University, Lisle, IL. November 2013.

D. Eric Walters. What Everyone Should Know About Sweeteners. Olivet Nazarene University, Bourbonnais, IL. February 2014.

D. Eric Walters. What Every Pharmacist Should Know About Sweeteners. University of New England College of Pharmacy, April 2014.

of Pharmacy, Annual Meeting, Chicago, IL, July 13-17,

Technologists, Annual Meeting, Chicago, IL, July 13-16,

Technologists, Annual Meeting, Chicago, IL, July 13-16,

Toolbox: Selected Tools and Selected Applications. Rock River Section, American Chemical Society, Rockford, IL,

. What Everyone Should Know About Sweeteners. Olivet Nazarene University, Bourbonnais,

. What Every Pharmacist Should Know About Sweeteners. University of New England College

Arun K. Ghosh, PI. Design & synthesis of nonpeptide protease inhibitors. D. Eric Walters, Co-investigator. NIH/GMS, 4/1/96 - 8/31/16.

L.J. Mast, Ateequr Rahman, N. Horsley, and D. Bridges. Interprofessional Study. Vice President of Research’s Office, RFUMS. $5,000.

Kevin Rynn, S. Kent, Gloria Meredith, Tina Zook, K. Hankewych, Scott Hanes, S. Patel, Sarah Garber. National Association of Chain Drug Stores (NACDS) Community PREP Grant. $50,000 / 3 years.

Grants

The Haim and Jane Nagirner Weinstein

Centennial Symposium Series, 2013-2014

Monday, September 16, 2013 Dr. James McCormack, University of British Columbia Baffled, Befuddled and Bemused. How We Get Fooled Into Using Treatments That Really Don’t Work That Well

Thursday, October 3, 2013 Dr. Robert Chorvat, Jenrin Discovery Peripherally Restricted Cannabinoid-1 Receptor Blockers as Metabolic Disorder Therapeutics Devoid of CNS Liabilities, or, Why Pharmaceutical Companies Have ‘Gone to Pot’

Thursday, October 24, 2013 Dr. Guowei Fang, AbbVie From Bench to Bedside and Back: The Discovery and Development of Cancer Therapeutics

Thursday, November 14, 2013 Dr. Arun Ghosh, Purdue University Protein Backbone Binding - A Powerful Molecular Design Strategy to Combat Drug-Resistant HIV

Tuesday, January 7, 2014 Dr. James O’Donnell, University of Chicago Gap Junction Protein Connexin 43 (Cx43) Exacerbates Lung Vascular Permeability

Thursday, April 24, 2014 Ronald Weinert, Vice President, Healthcare Solutions, Walgreens Co The Pharmacist’s Role in Accountable Care

Monday, May 5, 2014 Dr. Wendy Duncan, Drake University Designing Instruction to Foster the Development of Professionally Mature Practitioners