scaderea ponderala involuntara - baicus · din bolile cronice de anemia feripriva 6. un studiu de...
TRANSCRIPT
![Page 1: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/1.jpg)
Scaderea ponderala involuntara
Proiect IDEI 2008
C Baicus
www.baicus.ro
![Page 2: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/2.jpg)
![Page 3: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/3.jpg)
![Page 4: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/4.jpg)
1. Studiu descriptiv, de evaluare a spectrului etiologic al SPI
2. Studiu diagnostic de evaluare a acuratetei TNF-alfa, IL-1 beta, IL-6, aFL ca markeri ai cancerului ca si cauza a SPI
3. Studiu diagnostic de evaluare a feritinei ca marker al cancerului gastrointestinal, mai sensibil decat anemia
4. Studiu diagnostic de validare a parametrilor clinici si biologici simpli (varsta, VSH, hemoglobina, fosfatazele alcaline, LDH, albumina), care au fost evidentiati in alte studii ca avand valoare predictiva privind existenta cancerului ca si cauza a SPI
![Page 5: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/5.jpg)
5. Studiu diagnostic de evaluare a testului de absorbtie a fierului pentru discriminarea anemiei din bolile cronice de anemia feripriva
6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie a frecventelor aparitiei lor la pacientii cu si fara cancer drept cauza a SPI si de evaluare a riscului de tromboze la pacientii cu si fara ac. anticardiolipinici.
![Page 6: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/6.jpg)
SPI
varsta, HLG, VSH, albumina, phalc, LDH, PCR,
feritina;
IL1,6, TNF, aFL
Anemie +
Fe,
Test de abs. Fe,
Mielogr+Perls Anemie -
externare 6 luni 3 luni
Dg
can
cer,
TV
P (
tele
fon
)
Dg
can
cer,
TV
P
aFL
II
3 eprubete cu dop rosu
2 eprubete cu dop rosu
Testul de absorbtie a Fe (pe stomacul gol): T0: sideremie Administrare 2 cps ferro-gradumet T2h: sideremie
![Page 7: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/7.jpg)
2009
![Page 8: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/8.jpg)
Inceput 2011
![Page 9: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/9.jpg)
![Page 10: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/10.jpg)
• 2009: finantare 50%
– achizitionare ELISA automat
• ian-mai 2010: oprit de la finantare
• iun-dec 2010: finantare %; obiectiv: 1 articol
ISI la sfarsitul anului
• 2011: ultimul an, finantare%
![Page 11: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/11.jpg)
![Page 12: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/12.jpg)
![Page 13: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/13.jpg)
![Page 14: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/14.jpg)
![Page 15: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/15.jpg)
![Page 16: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/16.jpg)
![Page 17: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/17.jpg)
![Page 18: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/18.jpg)
![Page 19: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/19.jpg)
![Page 20: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/20.jpg)
![Page 21: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/21.jpg)
![Page 22: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/22.jpg)
![Page 23: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/23.jpg)
![Page 24: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/24.jpg)
![Page 25: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/25.jpg)
![Page 26: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/26.jpg)
![Page 27: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/27.jpg)
![Page 28: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/28.jpg)
![Page 29: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/29.jpg)
![Page 30: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/30.jpg)
![Page 31: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/31.jpg)
AUC
Colorectal cancer Gastrointestinal cancer
AUC 95% CI AUC 95% CI
Feritina 0.765 0.713-0.813 0.746 0.691-0.794
Vem 0.669 0.612-0.725 0.627 0.568-0.684
Fe 0.650 0.584-0.710 0.636 0.571-0.697
Hb 0.552 0.491-0.609 0.590 0.530-0.646
Rdw 0.463 0.401-0.528 0.541 0.476-0.602
![Page 32: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/32.jpg)
Gastrointestinal cancer Colorectal cancer
95% CI 95% CI
Sensitivity (%) 86 67-95 93 69-100
Specificity (%) 57 51-62 56 50-62
Positive predictive value (%) 14 9-21 10 6-16
Negative predictive value (%) 98 94-100 99 96-100
Positive likelihood ratio 2 2.1
Negative likelihood ratio 0.24 0.13
Feritin100 as dg test
![Page 33: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/33.jpg)
Gastrointestinal cancer Colorectal cancer
95% CI 95% CI
Sensitivity (%) 59 39-77 64 39-84
Specificity (%) 76 71-81 75 70-80
Positive predictive value (%) 17 10-27 12 6-20
Negative predictive value (%) 96 92-98 98 95-99
Positive likelihood ratio 2.5 2.6
Negative likelihood ratio 0.54 0.47
Feritin50 as dg test
![Page 34: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/34.jpg)
Gastrointestinal cancer Colorectal cancer
95% CI 95% CI
Sensitivity (%) 68 47-84 64 39-84
Specificity (%) 51 45-57 50 44-56
Positive predictive value (%) 10 6-16 6 3-11
Negative predictive value (%) 95 90-98 97 92-99
Positive likelihood ratio 1.4 1.3
Negative likelihood ratio 0.63 0.71
Anemia as dg test
![Page 35: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/35.jpg)
Colon cancer Gastrointestinal cancer
Anemia, present Ferritin (100mcg/L) P<0.001 P<0.001
Ferritin (50 mcg/L) P=0.005 P<0.001
Ferritin (mcg/L) P<0.001 P=0.001
Anemia, absent Ferritin (100mcg/L) P=0.375 P=0.125
Ferritin (50 mcg/L) P=0.154 P=0.196
Ferritin (mcg/L) P=1.000 P=0.536
![Page 36: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/36.jpg)
http://www.equator-network.org
![Page 37: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/37.jpg)
![Page 38: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/38.jpg)
![Page 39: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/39.jpg)
![Page 40: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/40.jpg)
• Promising results of this study, slightly disagree with data recently published by the same authors. In a series of 253 pts with IWL (Baicus C, Caraiola S, Rimbas M, Patrascu R, Baicus A; for Grupul de Studiu al Scaderii Ponderale Involuntare. Utility of Routine Hematological and Inflammation Parameters for the Diagnosis of Cancer in Involuntary Weight Loss. J Investig Med. 2011 Jun 25), they showed a statistically association with cancer of all hematological and inflammation parameters. Among evaluated parameters, just erythrocyte sedimentation rate remained associated with cancer in the multivariate analysis, being AUC for ferritin levels significantly different from data currently submitted.
• 1) patients were enrolled on an objective evaluation or on a reported or a presumed basis of a weight loss and it coud be a cause of bias in the study group that could explain the low rate of gastrointestinal cancer reported in this study. 2)the protocol of the study was not standardised and every physician decided on the basis of himself suspicion of a gastrointestinal cancer to suggest a gastrointestinal endoscopic investigation to the patient. 3) Fecal occult blood test was included in the panel of the lab tests or not? 4) it would be interesting to know where the colorectal cancers were located in the colon (right vs left colon) and how many patients complaint of other symptoms out of IWL. 5) the group of patients was not stratified according to the age. It is known that colorectal cancer is increasing in the elderly population. This is probably another cause of the low rate of colorectal cancer observed in this study in which patient with IWL older than 18 were enrolled.
![Page 41: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/41.jpg)
![Page 42: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/42.jpg)
![Page 43: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/43.jpg)
![Page 44: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/44.jpg)
![Page 45: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/45.jpg)
![Page 46: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/46.jpg)
![Page 47: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/47.jpg)
![Page 48: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/48.jpg)
![Page 49: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/49.jpg)
![Page 50: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/50.jpg)
![Page 51: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/51.jpg)
![Page 52: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/52.jpg)
![Page 53: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/53.jpg)
![Page 54: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/54.jpg)
![Page 55: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/55.jpg)
![Page 56: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/56.jpg)
![Page 57: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/57.jpg)
![Page 58: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/58.jpg)
![Page 59: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/59.jpg)
![Page 60: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/60.jpg)
![Page 61: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/61.jpg)
![Page 62: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/62.jpg)
Figure 2. Receiver Operating Characteristic Curves of the Hernandez and Present Models in Patients Who Had Involuntary Weight Loss.
Baicus C, Rimbas M, Baicus A, Caraiola S, Grupul de Studiu al Scaderii Ponderale Involuntare (2014) Cancer and Involuntary
Weight Loss: Failure to Validate a Prediction Score. PLoS ONE 9(4): e95286. doi:10.1371/journal.pone.0095286
http://127.0.0.1:8081/plosone/article?id=info:doi/10.1371/journal.pone.0095286
![Page 63: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/63.jpg)
Table 5. Modified Regression Model For the Relation Between Clinical Variables and Probability of Having Cancer in Patients Who Had Involuntary Weight Loss*.
Baicus C, Rimbas M, Baicus A, Caraiola S, Grupul de Studiu al Scaderii Ponderale Involuntare (2014) Cancer and Involuntary
Weight Loss: Failure to Validate a Prediction Score. PLoS ONE 9(4): e95286. doi:10.1371/journal.pone.0095286
http://127.0.0.1:8081/plosone/article?id=info:doi/10.1371/journal.pone.0095286
![Page 64: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/64.jpg)
![Page 65: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/65.jpg)
![Page 66: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/66.jpg)
1. Studiu descriptiv, de evaluare a spectrului etiologic al SPI
2. Studiu diagnostic de evaluare a acuratetei TNF-alfa, IL-1 beta, IL-6 ca markeri ai cancerului ca si cauza a SPI
3. Studiu diagnostic de evaluare a feritinei ca marker al cancerului gastrointestinal, mai sensibil decat anemia
4. Studiu diagnostic de validare a parametrilor clinici si biologici simpli (varsta, VSH, hemoglobina, fosfatazele alcaline, LDH, albumina), care au fost evidentiati in alte studii ca avand valoare predictiva privind existenta cancerului ca si cauza a SPI
![Page 67: Scaderea ponderala involuntara - Baicus · din bolile cronice de anemia feripriva 6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie](https://reader031.vdocuments.mx/reader031/viewer/2022020217/5e15e14a9c48c1060b2b7825/html5/thumbnails/67.jpg)
5. Studiu diagnostic de evaluare a testului de absorbtie a fierului pentru discriminarea anemiei din bolile cronice de anemia feripriva
6. Un studiu de evaluare a prevalentei anticorpilor antifosfolipidici la pacientii cu SPI, de comparatie a frecventelor aparitiei lor la pacientii cu si fara cancer drept cauza a SPI si de evaluare a riscului de tromboze la pacientii cu si fara ac. anticardiolipinici.