Thought to make the coronavirus more infectiousAlters the shape of the spike and may helpit evade some antibodiesAlters the shape of the spike and may helpit evade some antibodiesImpacts ability to evade antibody-mediated immunityHelps the virus latch on moHelps the virus latch on more tightly to human cellsPredicted to enhance systemic infection andassociated with increased transmissibility

D614GdelH69V70

delY144

N439KN501YP681H

Key mutations:

First detected: United Kingdom

Alpha (B.1.1.7) B.1.177, B.1.258

May help the virus latch on tighterThought to make the coronavirus more infectiousReduces antibody recognition;Associated with vaccine resistanceHelps the virus bind more tightly to human cellsMay help the virus latch on tighterHelps the virus latch on moHelps the virus latch on more tightly to human cells

D215GD614GE484K

K417NL18FN501Y

Key mutations:First detected: South Africa

Beta (B.1.351) B.1.1.33

Thought to make the coronavirus more infectiousReduces antibody recognition;Associated with vaccine resistanceMay help the virus latch on tighterMay help the virus latch on tighterHelps the virus latch on more tightly to human cellsMay help the virus latch on tighterMay help the virus latch on tighter

Key mutations:

First detected: Brazil (and in Japan, detected in travelers from Brazil)

Gamma (P.1)

May be associated with increased transmissibility;Appears to be very similar to E484K and may beassociated with immune escapeDefining SNP associated with Delta variantMay give an advantage at spreading over other variantsMay help the virus latch on tighter and may resultin in increased transmissibility

*Absence of this mutation in the Delta variant

E484Q*

EFR156-158GL452RP681R

Key mutations:

First detected: India

Delta (B.1.617.2)Kappa (B.1.617.1)B.1.617.3

Reduces antibody recognition;Associated with vaccine resistanceAssociated with variant thatcauses increased transmissibility

L452R

S13I

Key mutations:

First detected: California (USA)

Epsilon (B.1.427/B.1.429)

Potential reduction in neutralizationby some antibody treatments

V1176F

Key mutation:

First detected: Brazil

Zeta (P.2)

Thought to make the coronavirus more infectiousAlters the shape of the spike and may helpit evade some antibodiesReduces antibody recognition;Associated with vaccine resistancePotential reduction in neutralization by someantibody tantibody treatmentsPredicted to enhance systemic infectionand associated with increased transmissibility

D614GdelH69V70

E484K

F888L

P681H

Key mutations:

First detected: United Kingdom/Nigeria

Eta (B.1.525) B.1.1.207

Associated with reduced susceptibility; reducedneutralization by convalescent and post-vaccination seraAssociated with reduced susceptibilityAssociated with reduced susceptibility; reducedneutralization by convalescent and post-vaccination sera

F157S

S477NT95I

Key mutations:

First detected: New York (USA)

Iota (B.1.526)

SNP associated with Mu VOI according to WHOSNP associated with Mu VOI according to WHOSNP associated with Mu VOI according to WHOSNP associated with Mu VOI according to WHOSNP associated with Mu VOI according to WHOAssociated with reduced susceptibility; reducedneutralization by convalescent and post-vaccination seraneutralization by convalescent and post-vaccination sera

A13057T A28272T P5743SR346KT1055AT95I

Key mutations:

First detected: Colombia

Mu (B.1.621)

Thought to make the virus more infectiousD614G

Key mutation:

B.1.1.298 (Mink Variant)

This graphic represents the most up-to-date information as of September 24, 2021.

SARS-CoV-2Variants and mutationsAs SARS-CoV-2 continues to mutate, there are numerous variants popping up around the world. As new variants arise, stay up to datethrough our Notable Variants blog.

We closely track literature and trends to design assaysfor detecting emerging SARS-CoV-2 mutations.Find the most up-to-date list of available assaysat thermofisher.com/mutationpanel

Did you know you can identify each of these key mutations using our TaqMan SARS-CoV-2 Mutation Panel? Create your custom panel

D614GE484K

K417TL18FN501YT20N