sales manual hematology - yeec

Sales Manual

agile – affordable – accurate

Hematology

Hemolyzer® 5

Hemolyzer® 3

www.analyticon-diagnostics.com


Content


Confidential! For internal use only!

What is a Blood Count? ................................................................................................................................... 1

Measuring Principles ....................................................................................................................................... 4

Parameters ...................................................................................................................................................... 7

Red Blood Cells ........................................................................................................................................ 7

Platelets ................................................................................................................................................... 9

White Blood Cells ................................................................................................................................... 10

Hemolyzer®3 ................................................................................................................................................. 12

Key Features and Benefits ..................................................................................................................... 13

Competitors ........................................................................................................................................... 15

Hemolyzer® 5 ................................................................................................................................................ 19

Key Features and Benefits ..................................................................................................................... 20

Competitors ........................................................................................................................................... 22

Notes ............................................................................................................................................................. 27

1

What is a Blood Count?



Blood Count

A complete blood count (CBC) is an important diagnostic test that provides information about the type and

number of blood cells contained in a patient sample. The sample is usually treated with EDTA to prevent

clotting. Qualitative or quantitative aberrances in the blood cells are indicators of a vast number of medical

conditions like anaemia, leukaemia or infections.

There are three types of blood cells: red blood cells (erythrocytes), white blood cells (leucocytes) and

platelets (thrombocytes). Red blood cells constitute about 95% of all blood cells. The percentage of red

blood cells in the total blood volume has been termed “hematocrit” (HCT or Ht) and is normally around

40% in women and around 45% in men.

The complete blood count can be ordered with or without differential (dt.: großes bzw. kleines Blutbild). A

complete blood count without differential gives information about red blood cells and platelets but only

gives the total number of white blood cells. The differential provides detailed information about the

different types of white blood cells.

Rendered images of the three main types of blood cells. A: White blood cell, B: Activated platelet and C: Red blood cell.

A

B C

2




Red Blood cells (RBC)

Red blood cells are the most common of all blood cells. They are responsible for delivering the oxygen

from the lung to the rest of the body. Normal red blood cells are disc-shaped with indentations on both

sides. Mature red blood cells do not possess a nucleus or other cell organelles and consist mainly of

hemoglobin, a protein containing iron atoms which are responsible for the red colour. Hemoglobin can

temporarily bind oxygen and will change its colour depending on the presence or absence of oxygen. It is

scarlet when bound to oxygen and dark red without.

White Blood cells (WBC)

White blood cells are part of the immune system. There are five types of white blood cells: neutrophil,

basophil and eosinophil granulocytes, and two types of agranulocytes, namely lymphocytes and

monocytes. Neutrophils are the most common white blood cells that target and destroy bacteria, viruses

and fungi. Lymphocytes, the second most common white blood cells, can be further divided into B-cells, T-

cells and natural killer cells (NK-cells). These cells identify and attack “invaders” (e.g. bacteria, parasites),

tumours and virus-infected cells. Monocytes migrate to other tissues where they differentiate into

Macrophages (function: disposal of cellular debris and pathogens) or dendritic cells (function:

“showcasing” foreign material to activate T-cells). Eosinophils mainly target multicellular parasites and play

a role in allergies and asthma. Basophils release histamine and also play a role in asthma and allergies.

Platelets (PLT)

Platelets are the smallest of all blood cells. Like red blood cells they do not contain a nucleus. They play an

important role in blood clotting. Damage to a blood vessel activates the platelets that aggregate to form a

plug that is then further strengthened by fibrin. Aggregated platelets secrete substances that promote the

repair of the damaged tissue. Normally, platelets are disc-shaped but will change to a stellate shape when

they are activated.

3




Rendered images of the five main types of white blood cells, Erythrocytes and Platelets.

4


Measuring Principles


In general, plasma treated with anticoagulants that bind calcium (mainly EDTA) is used for blood counts. A

blood count can be done manually or by an analyzer.

For a manual blood count a defined volume of diluted blood is put into a counting chamber and the blood

cells are counted under a microscope. For a differential a thin layer of blood is smeared on a microscope

slide and then stained. The percentage of each cell type is determined for a large number (usually 100) of

white blood cells. Manual blood counts are especially useful for patients with abnormal blood cells that an

automated analyzer might not identify reliably.

Automated blood counts are performed by special analyzers. Blood flows through a thin tube and passes

detectors that identify and count the cells (flow cytometry). It is vital that the cells pass the detectors one

at a time. This is usually achieved by hydrodynamic focussing, where the blood is injected into a stream of

flowing liquid, e.g. saline solution (see figure). The different types of cells can be identified visually and/or

by measuring their impedance.

Flow cytometry

Laser light scatter technique

For visual identification and counting a laser beam is used. Cells passing

through the laser beam will deflect the light. Detectors then measure the

amount of remaining light or the amount of scattered light.

Forward scatter: light that is only minimally deflected. The size of the cells

determines the amount of forward scatter. Often, the light of the laser

beam itself is obscured so that only scattered light can reach the detector.

Side scatter: light that is deflected to the side. Complex structures inside

the cell cause side scatter. A Lens system focuses the scattered light onto a

detector usually placed at a right angle to the laser beam.

Different cell types can be distinguished by the amounts of forward and

side scatter, e.g. Lymphocytes (small size, low complexity = little forward

scatter, little side scatter); Monocytes (medium size, medium complexity =

average forward scatter, average side scatter); Granulocytes (large size,

high complexity = much forward scatter, much side scatter). Schematic drawing of the principles of hydrodynamic focussing and laser light scatter.

5




Aperture impedance technique

The impedance method (also known as Coulter method) has been used for automated cell counts since the

1950s. The detector consists of two measuring chambers connected only over a small aperture that

contain a solution with suspended cells. Two electrodes placed on either side of the aperture generate a

static electrical field. The voltage measured between those two electrodes depends on the size of the

aperture and the conductivity of the solution.

In order to count the cells the solution has to flow through the aperture from one chamber into the other.

The impedance (or electrical resistance) of the cells is much higher than that of the surrounding fluid.

Accordingly, cells passing through the aperture cause a disturbance of the electrical field by basically

“blocking” the electric current. The amplitude of this signal is proportional to the size of the cell. As is the

case for the laser light scatter technology it is very important that the cells pass through the aperture in

single file.

Schematic drawing of the principles of the impedance method of cell counting.

6




Fluorescence

It is also possible to use fluorescence to directly mark certain cell types. The cells are labelled with specific

antibodies coupled with fluorescent material. When this fluorescent material is “activated” (usually by

exposure to light) it will emit light of a specific wavelength (aka colour). By filtering the emitted light

multiple labels emitting light of different wavelengths can be measured simultaneously.

Light absorbance

For direct measurement of hemoglobin the red blood cells are destroyed so that the hemoglobin is

released. Then the intensity of light of a specific wavelength that has passed through the solution is

measured.

SI-prefixes

The following prefixes are used to denote fractions of a unit. The Greek letter μ is sometimes replaced by a

lowercase u.

Prefix Symbol Factor

deci- d 10-1

centi- c 10-2

milli- m 10-3

micro- μ 10-6

nano- n 10-9

pico- p 10-12

femto- f 10-15

7


Parameters


Red Blood Cells

An increase in red blood cells is termed polycythaemia (also known as erythrocytosis), a decrease is called

anaemia. Anaemia is the most common blood disorder. Different forms can be classified according to the

size of the red blood cells (micro-, normo- or macrocytic) and the amount of hemoglobin in each cell

(hypo-, normo- or hyperchromic). Qualitative or quantitative changes in the red blood cells can be due to a

variety of causes. For differential diagnosis a number of parameters are determined. The plausibility of the

values for the three main parameters can easily be checked with the following rule:

RBC x 3 = HGB

HGB x 3 = HCT

RBC (Red Blood Cells)

Number of red blood cells, given in cells per picolitre.

Normal range: 3.8-5.2 cells/pl (women), 4.4-5.9 cells/pl (men)

Low numbers of red blood cells can be due to decreased production, a shortened lifespan or a destruction

of the red blood cells (hemolysis), blood loss, or increased volume of blood plasma.

Heightened levels of red blood cells can be caused by increased production in the bone marrow,

chronically low oxygen levels (e.g. in high altitudes), or decreased plasma volume (e.g. due to dehydration).

HCT (Hematocrit; also Packed Cell Volume, PCV)

Percentage of red blood cells in the total blood volume.

Normal range: 35-47% (women), 40-52% (men)

The hematocrit can easily be determined by centrifuging blood in a capillary tube. Therefore this test can

also be performed outside a clinical laboratory. Automated analyzers will calculate the HCT-value as MCV *

RBC/1000 (in this case MCV is measured directly). The HCT levels of professional athletes are monitored to

check for blood doping.

HGB (Hemoglobin)

Amount of hemoglobin, given in grams per decilitre.

Normal range: 11.7-15.7 dl (women), 13.3-17.7 dl (men)

HGB is measured photometrically at 540nm.

8


Parameters


MCV (Mean Corpuscular Volume)

Mean volume of the red blood cells, given in femtolitre.

Normal range: 81-100 fl

The MCV is calculated as HCT[1/1]*1000/RBC when the blood count is done manually. Automated

analyzers size the red blood cells and determine the MCV from the histogram.

MCH (Mean Corpuscular Hemoglobin)

Mean amount of hemoglobin in a red blood cell, given in picogram.

Normal range: 26-34 pg (women), 27-34 pg (men)

Calculated as HGB*10/RBC

MCHC (Mean Corpuscular Hemoglobin Concentration)

Mean hemoglobin concentration in a red blood cell, given in percent.

Normal range: 31.4-35.8% (women), 31.5-36.3% (men)

Calculated as HGB*100/HCT

RDW (Red Blood Cell Distribution Width)

Variation in size of the red blood cells.

Normal range: 11-15%

Values lower than the normal range are not clinically significant. Heightened values are found in certain

forms of anaemia (e.g. iron deficiency anaemia). The RDW is calculated as:

(Standard deviation of MCV*100)/MCV

RDW_CV (Red Blood Cell Distribution Width – Coefficient Variation) is calculated using the width of the

MCV distribution curve at 60% of peak.

RDW_SD (Red Blood Cell Distribution Width – Standard Deviation) is calculated using the width of the MCV

distribution curve at 20% of peak.

9


Parameters


Platelets

PLT (Platelets)

Number of platelets, given in cells per nanolitre.

Normal range: 150-450 cells/nl

Low platelet levels (thrombocytopenia) can be due to problems with the production of platelets (e.g. in

sepsis or some forms of leukaemia), increased consumption or destruction, or a side-effect of certain drugs

(e.g. chemotherapy drugs like interferon). Thrombocytopenia can lead to bruising or bleeding. EDTA (the

anticoagulant routinely used for blood counts) can induce a pseudothrombocytopenia that can be

detected by a second platelet count using citrate instead of EDTA.

An increased platelet count (thrombocytosis) can be reactive (e.g. after blood loss, in inflammation or in

iron deficiency anaemia) or essential/primary (in myeloproliferative diseases, when the bone marrow

produces an excess number of cells). Reactive thrombocytosis is transient and usually does not carry an

increased risk of thrombosis. Essential thrombocytosis can lead to thrombosis in some patients.

MPV (Mean Platelet Volume)

Mean volume of the platelets, given in femtolitre.

Normal range: 7.5-11.5 fl

When platelets are produced in increased numbers they are larger than normal while they are smaller

when produced in small numbers. Thus, MPV size gives information about platelet production in the bone

marrow.

PCT (Plateletcrit/Thrombocrit)

Percentage of platelets in the total blood volume.

Normal range: 0.1-0.5%

Calculated as PLT * MPV * 100.

PDW (Platelet Distribution Width)

Variation in size of the platelets.

Normal range: 12-16%

Values higher than the normal range indicate increased destruction of platelets.

10


Parameters


White Blood Cells/Differential

WBC (White Blood cells)

Number of white blood cells, given in cells per nanolitre.

Normal range: 4.3-10 cells/nl

Increased numbers of white blood cells (leukocytosis) is commonly found in connection with acute

infections (bacterial, viral, fungal, parasitic), inflammation, allergies, cancer (primarily leukaemia),

poisoning, and as a side effect of certain medications (e.g. corticosteroids). Stress, physical exercise or

smoking can also induce a modest increase in leukocyte numbers. For differential diagnosis it has to be

determined which type of white blood cell is primarily increased in number. Most commonly, leukocytosis

is due to an increase in the number of neutrophils.

A decrease (leukopenia) in the number of white blood cells increases the risk of infection for the patient. It

is a commonly found after chemotherapy, in some types of cancer or infections (e.g. HIV), in aplastic

anaemia, as a side effect of treatment with certain drugs, but also as a result of physical or mental stress.

NEU# (Neutrophils, total number)

NEU% (Neutrophils, percentage)

Number of neutrophils, given in cells per nanolitre or in percentage of all white blood cells.

Normal range: 2.5-7.5 cells/nl

40-75% of WBC

An increase in the number of neurophils (neurophilia) is generally associated with bacterial infection or

tissue necrosis (e.g. heart attack, burns).

LYM # (Lymphocytes, total number)

LYM% (Lymphocytes, percentage)

Number of lymphocytes, given in cells per nanolitre or in percentage of all white blood cells.


20-45% of WBC

Heightened lymphocyte counts (lymphocytosis) is the result of acute or chronic infections (e.g. pertussis,

tuberculosis), especially in children. Acute or chronic lymphocytic leukaemia (CLL) is also characterized by

lymphocytosis.

11


Parameters


MON# (Monocytes, total number)

MON% (Monocytes, percentage)

Number of monocytes, given in cells per nanolitre or in percentage of all white blood cells.


2-8% of WBC

Increased monocyte numbers (monocytosis) can often be found in the recovery phase of an acute

infection, but also in chronic infection (e.g. tuberculosis, malaria) and in certain types of cancer (e.g.

Hodgkin disease, chronic myelomonocytic leukaemia CML).

EOS# (Eosinophils, total number)

EOS% (Eosinophils, percentage)

Number of eosinophils, given in cells per nanolitre or in percentage of all white blood cells.


1-6 % of WBC

The most common causes for an increase in the number of eosinophils (eosinophilia) are allergies (e.g. hay

fever, asthma) or parasitic infections. It can also be elicited by in certain forms of cancer or infections.

BAS# (Basophils, total number)

BAS% (Basophils, percentage)

Number of basophils, given in cells per nanolitre or in percentage of all white blood cells.

Normal range: 0-0.1 cells/nl

0-1% of WBC

An abnormal elevation of the basophil number (basophilia) is rare. It is found in myeloproliferative

diseases, especially in CML, and can also be found in patients with certain infections or with severe thyroid

hyperfunction.

12

Hemolyzer® 3



The compact solution in 3-Part-differential hematology

13


Hemolyzer® 3: Key Features and Benefits


Reliable and accurate

The high resolution colour LCD allows easy monitoring of the results with large and clearly interpretable histograms.

Up to 10.000 results, including histograms, are stored in the database.

Full quality control management system including Levey-Jennings diagrams.

Minimal maintenance due to a reliable system that enables a self diagnostic function.

Automatic cleaning of the fluidic systems from dust particles with every start-up.

Automatic clogging prevention of the apertures by applying high voltage pulses after each measuring cycle.

Easy-to-use and agile

Robust system requiring minimal laboratory space and minimal maintenance. The sample is being aspirated inside the analyzer, which guarantees maximal hygiene by practically

excluding the risk of injuries for the user. Easy to use user interface with 6 icon-labelled software buttons and 6 hardware function buttons,

cursor and numeric keys. Optional, external bar code reader minimizes data entry error and enables rapid data processing. Built-in thermal printer and possibility to connect external printer. Possibility of further processing of the measured data by interfacing the Hemolyzer® 3 with a host

computer (RS232 or USB).

Hemolyzer® 3 is Analyticon’s compact high quality solution in hematology intended for hospitals and physician offices. The new hematology analyzer uses established methods like impedance and photometric measurements and is characterized by delivering reliable and accurate results while being easy-to-use, efficient and affordable at the same time. The Hemolyzer® 3 provides 20-parameters complete blood count including a 3-part WBC differential at a throughput of 60 samples per hour.

14




Efficient and affordable

Intelligent and solid design provides maximum value at low running costs High throughput of 60 samples per hour (results within 60 seconds) Whole blood aspiration volume is only 25 μl Uses only 3 reagents (cyanide-free) Automatic monitoring of reagent status

Reagents & Consumables All our reagents are cyanide-free and have extended shelf life. Reagents Name Code Pack Size

Isotonic Diluent Hemolyzer-Diluent HE3201 20 L Hemolysing Agent Hemolyzer-3-Lyser HE3101 1 L Cleaner Hemolyzer-3-Cleaner HE3301 1 L HE3302 5 L Consumables Name Code Pack Size

Cleaner (external) Hemolyzer-Hypocleaner HE3401 100 ml Control Hemolyzer-3-Control (L, N, H) HE3501 3 x 4.5 ml

15


Hemolyzer® 3: Competitors


Model Hemolyzer® 3

Cell-dyn® 1800 AC•T Diff AC•T Diff2 ABX Micros 60

Distributor Analyticon Abbott Beckman Coulter Beckman Coulter Horiba

Parameters WBC diff. 3 3 3 3 3 Number of Parameters 20 18 18 18 18 Histograms WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT

Throughput (PT/h) 60 60 50 50 60 (open); 55(closed)

Samples Sample Volume [μl] 25 30 12 18 10

Open/Closed Sampling /- /- /- / / STAT Function

Reagents Number of Reagents 3 3 3 3 3

Hardware Bar Code Reader optional optional optional Autoloader (Capacity) - - - - - Standalone - - - Touch Screen - - - Internal Printer - - -

RS-232/USB / /- /- /- /-

Software Database Capacity 10,000 10,000 250 250 1;

78 (smart card) QC Levey-Jennings Levey-Jennings Levey-Jennings, Levey-Jennings

Dimensions Size (WxDxH) [cm] 35x49x38.5 66x44x52 38x42x39 45x49x40 36x42x32 Weight [kg] 15 55 16 20 14 Operating Temperature 15-35°C 18-30°C 16-34°C

16




Model Hemolyzer® 3

M 16M/C

/20M/C

M 16S/20

S CA 620 KX 21

Distributor Analyticon Medonic Medonic Medonic Sysmex

Parameters WBC diff. 3 3 3 3 3 Number of Parameters 20 16/20 16/20 9/16/20 18 Histograms WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT

Throughput (PT/h) 60 65 65 60 60

Samples Sample Volume [μl] 25 100 (open);

250 (closed) 300 125 50

Open/Closed Sampling /- / (C only) / /optional /- STAT Function


Hardware Bar Code Reader optional optional optional Autoloader (Capacity) - - (2x20) - - Standalone - - Touch Screen - - - Internal Printer - - -

RS-232/USB / / / / /

Software Database Capacity 10,000 220 300

QC Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings

Dimensions Size (WxDxH) [cm] 35x49x38.5 29x41x46 33x43x46 42x35x46 42x48x36 Weight [kg] 15 18 22 22 28 Operating Temperature 15-35°C 18-32°C 18-32°C 18-32°C

17




Model Hemolyzer® 3

BC 3000+ BC 3200 BC 3600

Distributor Analyticon Mindray Mindray Mindray

Parameters WBC diff. 3 3 3 3 Number of Parameters 20 19 19 21 Histograms WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT

Throughput (PT/h) 60 60 60 60

Samples Sample Volume [μl] 25 13 13 20

Open/Closed Sampling /- /- -/ /optional STAT Function

Reagents Number of Reagents 3 3 5 3

Hardware Bar Code Reader optional optional optional optional Autoloader (Capacity) - - - - Standalone

Touch Screen - - -

Internal Printer

RS-232/USB / / / /

Software Database Capacity 10,000 35,000 35,000 40,000

QC Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings

Dimensions Size (WxDxH) [cm] 35x49x38.5 39x46x40 39x46x42 45x40x45 Weight [kg] 15 21 25 28 Operating Temperature 15-35°C 15-30°C 15-30°C 15-30°C

18




Model Hemolyzer® 3

Celltac α MEK-6400/6410/6420

Mythic 18 H18 light Celly Plus

Distributor Analyticon Nihon Kohden Orphee SFRI Biocode Hycel

Parameters WBC diff. 3 3 3 3 3 Number of Parameters 20 18 18 20 18 Histograms WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT WBC, RBC, PLT

Throughput (PT/h) 60 63 60 60 60

Samples Sample Volume [μl] 25 30 9.8 9.6 10

Open/Closed Sampling /- / /- STAT Function


Hardware Bar Code Reader optional optional optional optional Autoloader (Capacity) - - - - - Standalone -

Touch Screen - -

Internal Printer optional optional RS-232/USB / /- / / /

Software Database Capacity 10,000

400 1,500 20,000 1,000

QC Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings

Dimensions Size (WxDxH) [cm] 35x49x38.5 23x45x38.3 25x34x35 33x43x38 32x35.2x36.8 Weight [kg] 15 9 23 9.5 Operating Temperature 15-35°C 18-35°C 18-35°C

19


Hemolyzer® 5


The advanced solution in 5-Part-differential hematology

20




Reliable and accurate

Results are displayed on 2 histograms and 2 scattergrams

More than 100.000 results, including histograms, are stored in the database

Improved diagnostic flagging system Full quality control management

including Levey-Jennings diagrams Closed and open tube sampling is

supported; closed tube sampling with cap piercing and cap recognition mechanism (Monovette®, Vacutainer®, Vacuette®).

Easy-to-use and agile

The Hemolyzer® 5 features smart software on a large colour touch screen, which is intuitive, easy-to-use and straightforward

Robust system requiring minimal laboratory space and minimal maintenance Throughput of 60 samples per hour (STAT & Rack mode) 4 USB ports and RS232 interface Windows® compatible printers are supported STAT measurement can be started anytime by pushing the start button on the front panel with minimal

interruption of routine workflow Walk-away automation using the autoloader with a capacity of 100 vials Integrated bar code reader eliminates data entry error and enables rapid data processing Addition of Autoloader unit is possible at any time and will be automatically recognized by the software

Hemolyzer® 5 The instrument uses well established methods such as impedance and photometric measurements as well as an innovative optical measurement (laser-based scattering technology) in order to guarantee precise and accurate 24 parameter complete blood count profile including 5-part WBC differential results. The autoloader unit enables a walk-away automation of closed tube sampling, including cap-recognition and cap piercing, with a capacity of 100 vials at a throughput of 60 samples per hour.

21




Efficient and affordable

Intelligent and solid design provides maximum value at low running costs Optimized workflow increases productivity and reduces hands-on-time Uses only 3 reagents (cyanide-free) Automatic monitoring of reagent status Reduced daily routine improves efficiency Long-lifetime laser diode ensuring optimal performance using a high-tech flow cuvette

Reagents & Consumables All our reagents are cyanide-free and have extended shelf life. Reagents Name Code Pack Size

Isotonic Diluent Hemolyzer-Diluent HE3201 20 L Hemolysing Agent Hemolyzer-5-Lyser HE5101 5 L Isotonic Diluent Hemolyzer-5-Diff 5P HE5201 1 L HE5205 5 L Consumables Name Code Pack Size

Cleaner (external) Hemolyzer-Hypocleaner HE3401 100 ml Control Hemolyzer-5-Control (L, N, H) HE5501 3 x 3 ml

22




Model Hemolyzer® 5

Cell-dyn® 3200 CS

Cell-dyn® 3200 AL

Cell-dyn® 3700 CS

Cell-dyn® 3700 SL

Distributor Analyticon Abbott Abbott Abbott Abbott

Parameters WBC diff. 5 5 5 5 5 Number of Parameters 24 22 22 23 23 Histograms RBC, PLT RBC, PLT RBC, PLT RBC, PLT RBC, PLT

Scattergrams 4diff (L-M-N-E),

BAS WBC, RBC, PLT, RET

WBC, RBC, PLT, RET

WBC, RBC, PLT WBC, RBC, PLT

Throughput (PT/h) 60 61 (closed); 71 (open)

58 (closed); 72 (open)

90 90

Samples Sample Volume [μl] 100 240 (closed);

150 (open) 240 (closed); 150 (open)


355 (AL); 240 (closed); 130 (open)

Open/Closed Sampling / / / / / STAT Function


Hardware Bar Code Reader optional

Autoloader (Capacity) optional (100) - (50) - (100) Internal PC + Monitor - - - - Touch Screen - - - - Internal Printer - - - - - RS-232/USB 1/4 /- /- /- /-

Software Database Capacity 100,000 10,000 10,000 10,000 10,000 QC Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings

Dimensions Size (WxDxH) [cm] 40x45x50 83x48x59 83x48x74 76x61x56 76x68x79

with optional AL XXx45x50 Weight [kg] 35 97 106 86 131

with optional AL 49 Operating Temperature 15-35°C 15-30°C 15-30°C 15-30°C 15-30°C

23




Model Hemolyzer® 5 AC•TTM

5 Diff OV/CP

AC•TTM

5 Diff AL HmX ABX Pentra (XL) 80

Distributor Analyticon Beckman Coulter Beckman Coulter Beckman Coulter Horiba

Parameters WBC diff. 5 5 5 5 5 Number of Parameters 24 26 26 24 26 Histograms RBC, PLT WBC, RBC, PLT WBC, RBC, PLT RBC, PLT WBC/BAS, RBC,

PLT Scattergrams 4diff (L-M-N-E),

BAS 4diff (L-M-N-E) 4diff (L-M-N-E) 4diff (L-M-N-E)

Throughput (PT/h) 60 60

80 75 80

Samples Sample Volume [μl] 100l 53 (CBC + diff);

30 (CBC) 53 (CBC + diff); 30 (CBC)


53 (CBC + diff); 30 (CBC)

Open/Closed Sampling / / (CP) / / / STAT Function


Hardware Bar Code Reader optional optional

Autoloader (Capacity) optional (100) - (100) (100) Internal PC + Monitor (OV)/-(CP) - -

Touch Screen - - -

Internal Printer - - - - (laser) RS-232/USB 1/4 / / / /2

Software Database Capacity 100,000 10,000 10,000 5,000 10,000 QC Levey-Jennings IQAP IQAP IQAP Levey-Jennings

Dimensions Size (WxDxH) [cm] 40x45x50 44.4x58x50.1 81.5x58x54 61.5x61.7x84.8 82x57x54cm

with optional AL XXx45x50 Weight [kg] 35 36.2 55 94.5 55

with optional AL 49 Operating Temperature 15-35°C 16-34°C 16-34°C 16-32°C

24




Model Hemolyzer® 5 BC 5300 BC 5380 BC 5500

BC 5800

Distributor Analyticon Mindray Mindray Mindray Mindray

Parameters WBC diff. 5 5 5 5 5 Number of Parameters 24 27 27 27 29 Histograms RBC, PLT

3 3 RBC, PLT RBC, PLT

Scattergrams 4diff (L-M-N-E), BAS

1 1 4diff (L-M-N-E), BAS

4diff (L-M-N-E), BAS

Throughput (PT/h) 60 60 60 80 (AL); 60 (manual)

90

Samples Sample Volume [μl] 100 20 (CBC + diff);

15 (CBC) 20 (CBC + diff); 15 (CBC)



Open/Closed Sampling / /- /- / / STAT Function


Hardware Bar Code Reader optional optional optional optional Autoloader (Capacity) optional (100) - (30) optional (50) optional (50) Internal PC + Monitor - - - - Touch Screen - -

Internal Printer - - - - - RS-232/USB 1/4 /4 /5

Software Database Capacity 100,000 40,000 40,000 40,000 40,000 QC Levey-Jennings

Dimensions Size (WxDxH) [cm] 40x45x50 41x53x47 66.4x61.3x58.5 66.4x61.3x58.6

with optional AL XXx45x50 66.4x~73x58.6 66.4x~73x58.7 Weight [kg] 35 45 73 76

with optional AL 49 79 84 Operating Temperature 15-35°C 15-30°C 15-30°C 15-30°C 15-30°C

25




Model Hemolyzer® 5

XS 800i XS 1000i XT 1800i/2000i

Distributor Analyticon Sysmex Sysmex Sysmex

Parameters WBC diff. 5 5 5 5 Number of Parameters 24 24 24 24/31 Histograms RBC, PLT

RBC, PLT RBC, PLT RBC, PLT


4diff, WBC/Baso, PLT, Ret (2000i)

Throughput (PT/h) 60 60 60; AL: 52

80

Samples Sample Volume [μl] 100 20 20 85;

150 (AL)

Open/Closed Sampling / /- / / STAT Function

Reagents Number of Reagents 3 4 4 5

Hardware Bar Code Reader optional optional optional optional Autoloader (Capacity) optional (100) - optional (20) (50)

Internal PC + Monitor - - - Touch Screen - - - Internal Printer - - - - RS-232/USB 1/4 / /

Software Database Capacity 10,0000 10,000 10,000 10,000 QC Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings

Dimensions Size (WxDxH) [cm] 40x45x50 32x50x41 32x40x41 53x63x50

with optional AL XXx45x50 45x42x63 53x63x72 Weight [kg] 35 24 24 52

with optional AL 49 38 59 Operating Temperature 15-35°C 15-30°C 15-30°C 15-30°C

26




Model Hemolyzer® 5 Celltac E MEK-7222

Celltac E MEK-8222

Mythic 22 OT/CT Mythic 22 AL

Distributor Analyticon Nihon Kohden Nihon Kohden Orphee Orphee

Parameters WBC diff. 5 5 5 5 5 Number of Parameters 24 22 22 22 22 Histograms RBC, PLT

RBC, PLT RBC, PLT


5-diff 5-diff

Throughput (PT/h) 60 51 80 50(OT)/45(CT)

Samples Sample Volume [μl] 100 55 (CBC + diff);

30(CBC) 56 (CBC + diff); 30 (CBC)

17 (OT)/20 (CT)

20

Open/Closed Sampling / /optional /optional / (CT only) / STAT Function


Hardware Bar Code Reader optional optional optional optional

Autoloader (Capacity) optional (100) - (50) - (50) Internal PC + Monitor

Touch Screen

Internal Printer - optional optional - - RS-232/USB 1/4 / / 1/2 1/5

Software Database Capacity 100,000 100,000 1,500 1,500 QC Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings Levey-Jennings

Dimensions Size (WxDxH) [cm] 40x45x50 61.3x58.3x55 25x34x35 48x40x40 38.2x48.5x52

with optional AL XXx45x50 Weight [kg] 35 55 11 25 38

with optional AL 49 Operating Temperature 15-35°C 18-34°C

27


Notes


28


Notes


29


Notes


sales manual hematology - yeec

Documents