s4002 sitagliptin
TRANSCRIPT
Product Information
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are important incretin hormones contributing to 50-70% of the stimulation of insulin secretion after a meal.Dipeptidyl-peptidase IV(DPP-4) inhibitors inhibit the degradation of GLP-1 and GIP as well as that of other regulatory peptides.[1] Sitagliptin abolished sDPP-IV effects on splenic CD4+ T-cell migration whereas incretins decreased migration of lymph node, but not splenic, CD4+ T-cells. Sitagliptin decreases migration of splenic CD4+ T-cells through a pathway involving Rac1/VASP, whereas its inhibitory effects on the migration of lymph node CD4+ T-cells involve incretin-activation of the NF-κB pathway.[2]It is eliminated renally, with a terminal half-life of 11.8-14.4 hours. [3]
Biological Activity
[1] Gallwitz B. Drugs Today (Barc). 2007 Nov; 43(11):801-14
[2] Su-Jin Kim et al. Diabetes, 2010 July; 59(7):1739-1750
[3] Shannon A Miller et al. The Annals of Pharmacotherapy. 40(7):1336-1343
References
Novel Kinase Inhibitors for cell signaling & oncology research
S4002 Sitagliptin
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
407.31C16H15F6N5ODMSO99%at -20℃ 2 years486460-32-6
Notes
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℃
Synonyms: MK-0431, Januvia
» DPP-4
F
F
F
N
ONH 2
N
NN
CF 3