1. Product InformationNovel Kinase Inhibitorsfor cell signaling & oncology researchToll Free: S2004 Vicriviroc Malate(877)796-6397-- USA and Canada only -- CCR5Fax:+1-713-796-9816 Technical Data:Orders M.Wt:667.72 O+1-713-922-4115 Formula: C32H44F3N5O7enquiry@selleckchem.com N Solubility:DMSO N N Purity:99%CF 3Tech Support NNtech@selleckchem.com Storage: at -20 2 years O C 4H 6O 5(chemistry support) CAS No.: 541503-81-5Synonyms: SCH417690,SCH-Dtechbio@selleckchem.com(bio support)Web Biological Activitywww.selleckchem.com In order to determine if vicriviroc is a receptor agonist or antagonist, three functional assays were employed to measure the ability of the compound to block b-chemokine signaling in CCR5-expressing cells. A chemotaxis assay was first employed to determine the ability of vicriviroc to inhibit chemokine-mediated migration of a mouse Ba/F3 cell line stably expressing recombinant human CCR5. In this assay,vicriviroc showed equally potent inhibition of the chemotactic response to MIP-1 with IC50 values below 1 nM. The ability of vicriviroc to inhibit intracellular calcium releaseSelleck Overnight Delivery Service induced by receptor stimulation was also assessed. A assay utilized to demonstrate the ability of vicriviroc to inhibit CCR5 receptor signaling was a GTPS exchange assay. GTPS binding induced by RANTES. vicriviroc potently inhibited RANTES-induced signaling with mean IC50s of 4.2 nM. [1]Return Policy References Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or [1] Julie M. Strizki et al. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9discrepancies.Our team will take quick and appropriate action to correct any problem. Goods ordered in error can only be acceptedMSDS & CoA for return if made within 3 days of delivery, are unopened,have been stored correctly and Please visit www.selleckchem.com to download MSDS and CoA. are in good condition. Should you wish to return any item(s), prior authorization mustNotesbe received from our customer service team. Returns accepted will be subject to a 30% restocking charge.PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE. NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.For all product returns and product replace- ments,please contact Selleck directly by Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored underinfo@selleckchem.com or the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115. storage temperature,most are recommended stored at -20.Many products are stable in the short-term at temperatures that differ from that Please have on hand, the invoice number, required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save purchase order number,air bill number and you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage approximate date of shipment/receipt. recommendations on the product data sheet. Copyright 2010 Selleck chemicals