s1470 tsu 68
TRANSCRIPT
Product Information
TSU-68 has significant antitumor activity against many types of tumor xenograft explants in athymic mice. TSU-68 inhibits angiogenesis through several mechanisms, including the induction of apoptosis in vascular endothelial cells and tumor cells, resulting in perturbing existing tumor vascular function and also inhibiting newly synthesis angiogenesis for the tumor growth.[1] TSU-68, a molecular-targeting drug, has the effect on blocking the tyrosine kinase phosphorylation of the receptors not only for VEGF but also for PDGF and bFGF, and inhibiting angiogenesis. Studies using in vivo experimental models of cancers such as colon cancer have reported that TSU-68 has the effect on inhibiting tumor proliferation and metastasis through the inhibition of tumor angiogenesis. In vitro TSU-68 does not influence the proliferation of ovarian cancer cells.[2] The administration of TSU-68 does not influence the concentration of VEGF or PDGF in the ascetic fluid of mice with peritoneal dissemination of ovarian cancer. TSU-68 does not act directly on VEGF or PDGF, but binds to their receptors, thereby inhibiting their phosphorylation. [2]
Biological Activity
[1] Ueda Y et al. Cancer Chemother Pharmacol. 2010 Jul 30
[2] Machida S et al. Int J Cancer. 2005 Mar 20; 114 (2): 224-9
References
Novel Kinase Inhibitors for cell signaling & oncology research
S1470 TSU-68
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
310.35C18H18N2O3
DMSO99%at -20℃ 2 years252916-29-3
Notes
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Synonyms: SU6668
» VEGFR-PDGFR
NH
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NH
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