Upload File

rooms and doors - biocommunication · doors rna virus opens the door from fittest type to rna...

  • Home
  • Documents
  • Rooms and Doors - Biocommunication · Doors RNA virus opens the door from fittest type to RNA collectives : a personal account by Luis Villarreal ... transcription factors, GAG translation
15
Rooms and Doors RNA virus opens the door from fittest type to RNA collectives: a personal account by Luis Villarreal Center for Virus Research, University of California Irvine

Upload: others

Post on 22-Oct-2020

1 views

Category:

Documents


0 download

Report

TRANSCRIPT

  • RoomsandDoors

    RNAvirusopensthedoorfromfittesttypetoRNAcollectives:apersonalaccountbyLuisVillarreal

    CenterforVirusResearch,UniversityofCaliforniaIrvine

  • Competition- oldroom(individualfittesttype,lyticvirus,selfish,

    mathematical,gametheory,populationgenetics)

    vsCooperation- newroom

    (symbiosis,diffusegroupselection,persistentcryptic-virus,synergisticsocialgenomes,contextdependent,

    regulatorynetworks)

    Lyticvs persistentvirusasanecessaryset?!Silenceisgolden(andsmallRNAusuallyinvolved)

    Thevirosphere isboth!

  • Nolifeisfitunlessitisinthecontextofitscurrentvirosphere

    CollectiveofRNAsub-agents

  • Eigen’s QS: mutant halo around master fittest type (no interactions)A theoretical construct – little experimental reference

  • VSVVirionandGenome

    • Bulletshapedvirus• 5proteinspresentindifferentamounts(N,G,M,PandL)

    • ~11,000bases,genesinoppositeorderofhowyouseemRNA

    • LandPfunctiontogethertocapmRNA,generatemRNA,polyA +-senseviralmRNAandreplicateviralgenome(RNAsynthesisenzymesinvirion)

  • Transcriptional Polarity

    éDefectiveproduct;small(stem-loop)RNAs:stronginterferencewith‘masterfittesttype’– canpromotepersistence

  • Fig. 7

    QS#mixture#with#subpopula3ons#Subpopula3ons#work#together#####and#against#each#other#Not#needing#consensus#change#Can#suppress#‘Master#fi>est#type”###

    Esteban#Domingo,#J.#Sheldon#and#C.##Perales.#2012.##“Viral#Quasispecies#Evolu3on.”#Microbiology*and*Molecular*Biology*Reviews#76#(2):#159–216:#

    Polio/YFV#vaccine:#HCV#transplants#

    Can#be#dis3nct#regions#under#dis3nct#pressure#

    QSYC##(coopera3ve)#

  • Perales,Mateo,Matue,Domingo.2007JMB

  • Established characteristics of

    quasispecies evolution¨ Not fittest type; a consortia that needs errors

    (group selection with consensus type)¨ Participation of defectives and

    mutants important (the lethal/unfit)¨ Complementation, cooperation, interference

    preclusion, competition all occur¨ Diversity per se provides fitness¨ Preclusion of prior consensus type: dynamic

  • TheHCVexamplar:QSbasedidentity/exclusion

    DynamicpersistenceviaongoingRNAsynthesisQuasispeciesdeterminedbiologyGroup(clade)preclusion(identity)

    Theroleofstem-loopRNAinteractions- consortia

    Laskus T,WangL-F,Radkowski M,VargasH,Nowicki M,etal.2001.Exposureofhepatitiscvirus(hcv)rna-positiverecipientstohcv rna-positiveblooddonorsresultsinrapidpredominanceofasingledonorstrainandexclusionand/orsuppressionoftherecipientstrain.J.Virol. 75(5):2059–66

  • Archer,EvaJ.,etal."Long-RangeArchitectureinaViralRNAGenome."Biochemistry (2013).

    Satellitetobaccomosaicvirus(STMV)asthe‘hydrogen’of+RNAviruses(McPherson):coreroleforstem-loopRNAinteractions(1058nucs)

    Strongevidencethat‘cooperative’longdistanceRNA-RNAinteractions(kissingloops)areneededforgeneexpressionandreplication.(FMDV,HCV- IRES)

    RNAstem-loopsaspredecessors(viroids/hammerheads)– awaytocreateinteractingnetworks

  • Secondarystructureofthe5ʹ-UTRoftheHIV-1genomicRNA(Deforges etal2011)

    StemloopinteractionscrucialforRNAvirusreplication,RNAdimerization,provirusformation,regulation,packaging(Identity),bindtranscriptionfactors,GAGtranslation

    RNAisinteractingasaQS-C,DNAisstable

    ViruscanprovidesLTRs(viadefectives)enmasstohostDNA:.NewQS-CbasedRNAnetworkacquisition?

    Similarly,defectiveviralDNAcolonizationevents(i.e.Maverick)canalsoprovidediffuseinteractingstem-loopRNAs(polyadenylation)

    Sleiman,Dona,etal."InitiationofHIV-1reversetranscriptionandfunctionalroleofnucleocapsid-mediatedtRNA/viralgenomeinteractions."Virusresearch (2012)

  • Virusroleinoriginoftheplacenta:Immunity/gametedevelopment/behavior

    Darwinianview– exapted viralenv genesconvenientserialsourceofgenesformembranefusion&immuneregulation.Errorgeneratednetwork(serial)

    Problems:10independenteventsdiversityofroles/biologyongoingERV/env displacementtransportsimmunity/notbarrieraffectthefirstcelltodifferentiatefailuretoexplainnetworkoriginsdoesnotaccountforcoherentcomplexity

    Avirus-firstview– PersistenceaskeyviadefectivesviruspersistencemodifiesimmunityviaERV/QSandaddictionmodules,allowsgroupsurvivalandcreatesidentity

    networksBehavior- motherhood

    DistinctviralrolealsoinparasitoidwaspreproductionEXVIRUSOMNIA!


Woodfold Doors: Accordion Doors

Transcription. Define the following Messenger RNA Ribosomal RNA Transfer RNA Transcription Codon

jenis-jenis rna dan pemrosesan rna

MSc-Modul RNA-Biochemie file•small noncoding RNA •Influenza –ein RNA-Virus RNA Biochemie 02/1 MSc-Modul RNA-Biochemie. Protein-Welt RNA-Welt Prä-RNA-Welt RNA Biochemie 02/2

RNA-Regulationsmechanismen: RNA Interferenz · RNA Interferenz (Fire&Mello) RNA Moleküle können interferieren, d.h. insbesondere kann doppelsträngige RNA den Abbau von RNA und

custom doors - Wholesale Doors

Automatic Doors - Bi-fold Rolfe Ltd · Automatic Doors Sliding Doors Product code BFR SLIDE There are four types of Automatic doors, Swing doors, Sliding doors, Telescopic doors and

High speed doors - roll up doors - Industrial Doors

Transkriptiossa syntyy m-rna (lähetti-rna)

Royal wooden doors bangalore - supplier of Burma Teak Doors, Designer Veneer Doors, Moulded skin Doors, Pine Doors, Teak Veneer Doors, Membrane Doors, Laminated Doors, Flush doors,

RNA Molecules and RNA Processing Functions and Modifications of RNA Molecules

MedChem 401 RNA Viruses These viruses contain a genome composed of RNA Remember plus-sense vs. minus-sense RNA genomes Remember RNA-dependent RNA polymerases

Biocommunication and Natural Genome Editingdownload.e-bookshelf.de/...G-0000072887-0002355562.pdf · Preface Iwrotethisbookforbiologistsandthosewhoareinterestedinbothbiologicalaffairs

Teachingbd · 2018. 3. 18. · dna ii. dn rna ii. rna-aq rna trna. rrna, mrna, grna rna uaa, (jag rna dna i rna a dna b rna dna rna-q 1 dna-q i dna dna rna rna mrna i mrna dna i dnaÄ

RNA 6 - RNA MLP Back-propagation5

BOOK - Doors - Doors

RNA metabolism - WordPress.com 05, 2017 · RNA metabolism • DNA dependent synthesis of RNA • RNA processing • RNA dependent synthesis of RNA …

Benasque RNA 2012: RNA Motifs

Turbo-Decoding of RNA Secondary Structuregsharma/.../SharmaTurboDecodingRNASe… · RNA Structure Analysis: Motivation and Background RNA, noncoding RNA, RNA structure and its significance

RNA PROCESSING AND RNPs. RNA Processing Very few RNA molecules are transcribed directly into the final mature RNA. Most newly transcribed RNA molecules

Cornell University · 2800. 2600- 2200 L Analyzer: RNA Quality RNA Property Summary RNA Concentration (ng/uL) 2056057 25S/18S RNA Quality Number 7.8 RNA Property Summary RNA Concentration

RNA-Regulation: RNA Interference

2011 RNA-RNA and RNA-protein interactions in coronavirus replication and transcription

1 NOTES: Chapter 13 - RNA & Protein Synthesis Vocabulary: Messenger RNA (mRNA) Ribosomal RNA (rRNA) Transfer RNA (tRNA) Transcription RNA Polymerase Codon

ZYTOTM - Earthgifts · ZYTO TM The Global Leader in BioCommunication Voucher For One FREE Inner Health Scan Valued at: $35.00 Voucher ZYTO TM The Global Leader in BioCommunication

From fittest type to cooperative consortia - Biocommunication

mRNA Archeology - Biocommunication · RNA parasites Celular World Eukaryotes ... Archaea, Bacteria. Structural domains of primordial metabolism and translation Caetano-Anollés D

Transcription: RNA synthesis, RNA processing, “Algorithms ... · Transcription: RNA synthesis, RNA processing, Intron-exon structure Promoters: Regulation, Chromatin structure,

MSc-Modul RNA-Biochemie · • Influenza –ein RNA-Virus RNA Biochemie 11/1 MSc-Modul RNA-Biochemie. RNA Biochemie 11/2 Influenza. RNA Biochemie 11/3 Influenza „I had a little

Interior Panel Doors and Bifold Doors Camber Top€¦ · Interior Panel Doors and Bifold Doors by Masonite Keywords: Interior Doors, Panel Doors, Bifold Doors, Masonite Created Date:

RNA Interference for Tumor Therapy - IntechOpen › pdfs › 33115 › InTech-Rna... · RNA interference (RNAi) is a double-stranded RNA-induced gene silencing process, by which RNA

Turbo-Decoding of RNA Secondary Structure€¦ · RNA Structure Analysis: Motivation and Background RNA, noncoding RNA, RNA structure and its significance RNA structure prediction

Doors & Doors Presentation30112018 · 2019-12-23 · Doors and Doors India Pvt.Ltd manufactures fully finished, custom‐built certified Fire Doors, Flush Doors and Acoustic doors

RNA: Structure & Function. What is RNA? RNA is a nucleic acid called Ribonucleic Acid Functions of RNA: RNA transfers genetic information from the nucleus

RNA and Protein Synthesis · Web viewamino acid, anticodon, codon, gene, messenger RNA, nucleotide, ribosome, RNA, RNA polymerase, transcription, transfer RNA, translation Prior Knowledge