rita ellithorpe, md€¦ · rita ellithorpe, md board certified in anti-aging and integrative...
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Rita Ellithorpe, MDBoard Certified in Anti-Aging and Integrative Medicine
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• Optimize Your Patient’s Health
• Expand Your Practice
• Increase Your Revenue
How to Integrate Heavy Metal
Detox into Your Practice:
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What every health care professional should know.
• Contents• HM toxicity - significant clinical conditions
• Impact of HM on the health of your patients
• Diagnosis
• Chelation therapy
• Clinical benefits
• How to integrate chelation into you practice
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Toxic Heavy Metals
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Heavy Metal Toxicity A Significant Clinical Condition
Emerging Diseases, many with environmental factors associated with their causation, and Ecological Issues are pointed to by the CDC as
being among the top 10 major health risks in the 21st century.
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Toxic Metals are Everywhere!
l They invade our bodies (fat)
l They cause advanced aging
l They cause devastating diseases
l They erode our lives
l They cripple our children
l They can kill us and our families
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Blood vessels are key to your youth, beauty, health and life.
It’s OK to be vein as long as you protect your arteries
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Blood is your
Life’s Breath
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Prevention is Key6
We must detect disease long before it get worse
We can stop it naturally
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Toxic Metal Effects Need Antioxidant Rescue
• Toxic Metals• Act as oxidative catalysts
• Deplete cells of antioxidants and enzymes
• Increase hydroxyl radical hydrogen peroxide
• Increased cell and tissue damage occur
Data suggest that antioxidants play a role in abating some hazards of toxic metals.
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Ref: Ercal.N, “Toxic metals and oxidative stress in metal-induced oxidative damage,”
Curr. Top Med Chem. 2001 Dec;1(6):529-39
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Toxins Damage Cell Membranes 8
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Time-Lapse Microphotography of Toxins in Human Cells
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Major Toxic Heavy Metals
l Most Common Toxic Metals • Lead
• Cadmium
• Mercury
• Aluminum
• Nickel
• Arsenic
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Lead-induced Hypertension: Role of Oxidative Stress
l Chronic, low-level lead exposure causes hypertension in both animals and humans
l Inactivation of endogenous nitric oxide
l Reactive oxygen species (ROS) lowers enzyme activity
l Functional deficiency in nitric oxide
l Increase sympathetic activity & plasma norepinephrine
l Lead-induced inhibition of vascular smooth muscle
l ACE, angiotensin II, aldosterone, thromboxane
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Ref: Vaziri ND, Lead-induced Hypertension: Role of Oxidative Stress,
Curr Hypertens Rep. 2004 Aug;6(4):314-20
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There are NO Safe Levels of Heavy Metals
l Low levels are becoming dangerous
l Low levels accumulate
l Low levels become stored
l Low levels become higher
l Multiple toxins compound the danger
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Death Rates of Participants with Low Pb Levels in NHANES III Survey
17
39
4646
68
0
10
20
30
40
50
60
70
80
10 20 30
All Causes
Cardiovascular Diseases
Cancer
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Perc
ent In
cre
ase in M
ort
alit
y
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality. Arch Intern
Med, 2002, 162: 2443-2449
Blood Lead Levels (µg/dL)
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Random Blood Sampling of Dr. Ellithorpe’s Patients: Presence Excessively High Heavy Metals
100
22
17
0
25
50
75
100
Presence of Heavy Metals
Elevated Heavy Metals
Potentially Toxic Heavy Metals
14
Perc
ent of P
atients
N=251
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Health Conditions Associated with Heavy Metal Toxicity - Lead
• Central nervous system
• Kidneys
• Decrease reaction time
• Weakness in fingers, wrists, ankles
• Memory
• Anemia
• Carcinogenic
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Source: Agency for Toxic Substances & Disease Registry
*Source: DHHS
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Impact of Heavy Metals on the health of your patients
• Recognized by:• US Environmental Protection Agency (EPA)
• Food & Drug Administration (FDA)
• Centers for Disease Control (CDC)
• State Health Departments
• Treatment standards are needed• Preventative measures
• Comprehensive medicine with proven results
• Reduction of crisis management
Global Chronic Low Level Metal Toxicity
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Cancers Associated with Heavy Metals
Skin, Lung, Bladder, Kidney, Liver, Prostate
Liver, Esophageal, Lung, Prostate
Bladder, Kidney, Brain
Lung, nasal
Prostate
Lung
Lung
Lung
Lung
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Type of CancerHeavy Metal
Arsenic
Mercury
Aluminum
Nickel
Cadmium
Uranium
Tungsten
Antimony
Beryllium
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An Important Major Research Discovery
• Ninety Percent Reduction in Cancer Mortality after Chelation Therapy with EDTA
• Blumer, W., Cranton, E. Textbook on EDTA Chelation Therapy, 2nd ed. Ch, 12, Pp. 185-201
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Lab Diagnosis of Heavy Metals
• Provocation Agents
Common Agents ~ Half Life Collection
Period
EDTA 1 hr. 6-24 hrs.
DMPS (IV) 1 hr. 2-6 hrs.
DMPS (oral) 9 hr. 6-9 hrs.
DMSA 4 hrs. 6-9 hrs.
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Lab Diagnosis of Heavy Metals
• Urine - Home Mailer
• Feces - Home Mailer
• Hair - Home Mailer
• Blood - Blood draw – process and mail
Diagnostic Lab: Doctors Data Labs - www.doctorsdata.com
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Doctors Data Labs
Sample HM Report
www.doctorsdata.com
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What can we do about Toxins?
l Remove Toxins
l Repair Damaged Cells
l Revitalize Your Health
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Detoxamin Chelation Suppositories 23
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Chelation Cost comparison
• IV Chelation• Average IV Price - $125 or more per treatment
• 30 treatments recommended• Average Cost: $3750
• Detoxamin• Average Price: $199/container (2 month’s supply)• 6 month’s supply = 30 IV dosages• 6 months supply Cost: $ 597
84% less cost compared to IV Chelation
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Published pharmacokinetic study on Detoxamin
Proving Detoxamin’sAbsorption Rate and EDTA Permeability
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EDTA levels in blood over time following intravenous administration of 14 C-EDTA
0 2 4 6 8
0.0
0.5
1.0
1.5
2.0
2.5
3.0
55914
55915
55917
55918
Ppm
ED
TA
Equiv
ale
nts
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EDTA levels in blood over time following rectal administration of 14C-EDTA
0 2 4 6 8
0
5
10
15
20
25
30
35
40
55912
55911
55906
Time (Hour)
Ppm
ED
TA
Equiv
alents
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Detoxamin Suppositories Bioavailability
Intravenous Detoxamin
Bioavailability 100% 36 %
Amount in
Tissue*
4 14
Time in blood 1.5 hours 8 hours +
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*Blood - tissue ratio
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Before
After
treatment
with 60
Detoxamin
suppositories
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Effects of Detoxamin on Elevated Lead Urine Levels in Children
4.2
61.45
9
22.7
0
20
40
60
80
100
0 1 10 20 30
Pre-Treatment Baseline
After 1st Suppository
10 Days of Suppository
10 Days After Suppository
10 Days Additional Suppository
30
325.6
µg/d
L
Treatment Day
N=20
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Treatment with Detoxamin Chronic Prostate Pain Symptom - Total Scores
0
2
4
6
8
10
12
Total Mean Score
Pre Treatment
Post Treatment
*P<0.05
31
*
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Treatment with Detoxamin International Prostate Symptom Score (IPSS) Results
0
1
2
3
4
Incomplete
Emptying
Frequency Intermittency Urgency Weak Stream Straining Nocturia QOL Score
Pre Mean
Post Mean
*P<0.05
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*
*
*
*
*
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Date Ar Cd Pb Hg Ni
8/02 220 2.5 20 24 49
12/02 4.5 2.1 7.4 15 25
5/03 45 3.2 12 8.9 18
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42 y/o – W – F 145 lbs. – Photographer – Fibromyalgia – Chronic Fatigue – Hypothyroid
Practical Clinical Case Study With Detoxamin
Outcome: 11/04– Energy good – Exercise daily (45 mins) with mild to moderate
pain of fibromyalgia – increase daily activities
Patient F.K.
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Practical Clinical Case Study with Detoxamin
Date Cd Hg Pb Ni
5/03 1.7 30 43 9.5
2/04 1.0 2.6 27 17
2/05 1.0 18 27 13
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55 y/o – W – F – 131 lbs – School Teacher – Chronic LBP – Fatigue - Hypothyroid
Patient K.M.
Outcome: 7/04– Excellent energy – Exercise 3x/daily – water aerobics – Back
pain stable – Reduced need for medications
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Comparison of IV Chelation vs Detoxamin
IV
Chelation
Detoxamin
Non-Invasive No Yes
Quick and easy to use No Yes
Inexpensive No Yes
Increased safety No Yes
Broad spectrum metal removal Yes Yes
Clinically proven Yes Yes
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• Comprehensive Metabolic Panel• Albumin - Total Protein
• Total Bilirubin - Sodium
• Calcium - AST (SGOT)
• Chloride - Urea Nitrogen (BUN)
• Creatinine, Serum - Bicarbonate (CO2)
• Glucose - ALT (SGPT)
• Alkaline Phosphatase - C-Reactive Protein
• Potassium
No statistical difference in above lab parameters between pre and post treatment with Detoxamin in all subjects
Detoxamin Safety
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Dr. Ellithorpe’s Clinical Safety Experience with Detoxamin
• 9 years +, 4000 patients, over 400,000 doses of Detoxamin
• Results in General• Improved mental clarity• Increased energy• Increased endurance• Reduced blood pressure• Enhanced cardiovascular performance• Improved libido and erectile function and prostate conditions• Improved overall quality of life
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Begin with Positive Lifestyle Changes
• Patients should manage stress
• Don’t take on more than they can handle
• March in place 7 min/day
• Get enough sleep• 8 is the magic number
• Reduce carbohydrates
• Drink plenty of water
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Positive Lifestyle Changes
• Drink non-fluoridated, non-chlorinated water
• Half their weight in pounds as ounces
• Exercise on a regular basis• Even if it’s just walking for
30 minutes a day
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