Pratley/Endo Fellows/12Nov11

Florida Hospital

Richard Pratley, M.D.

Samuel Crockett Chair in Diabetes Research

Director , Florida Hospital Diabetes Institute

Senior Scientist, Translational Research Institute

Professor, Sanford Burnham Medical Research Institute

Orlando, Florida

Pratley/Endo Fellows/12Nov11

Adventist Health System

48 hospitals in 10 states

Over 8000 beds

Pratley/Endo Fellows/12Nov11

Florida Division of

Adventist Health System

● 25 Hospitals

● Patient Visits 2.3m+

● Beds 4,380+

● Employees 23,000+

● Net Revenue $2.8b+

Florida Hospital Hospital Visits 900,000+

Emergency Visits 350,000

Admissions 110,000+

Inpatient Beds 2,188+

Physicians 2,000+

Employees 15,000+

Centra Care Visits 300,000+

Primary Care Clinics 250,000+

Net Revenue $1.7b

Winter Park Memorial Hospital Florida Hospital East Orlando

The Walt Disney Pavilion at Florida Hospital for Children

Florida Hospital Kissimmee

Florida Hospital Celebration Health

Florida Hospital Altamonte

Florida Hospital Apopka

Florida Hospital Orlando

8 hospitals in Seminole, Orange, Osceola Counties

To improve the lives of

people with diabetes,

promote a healthy life

style, deliver

excellence in clinical

care and education,

and conduct research

leading to diabetes

prevention and a cure.

Our Mission…

To become a preeminent global leader for diabetes care,

education, and research.

Our Vision…

Patient Education

● Cooking Demonstrations

● Florida Hospital TV Diabetes Channel

● Web-based interactive modules

FHDI Education

FHDI Education

FHDI Education

FHDI Education

ORLANDO

LAKE

NONA

TRI

Mission: To extend and improve the quality of lives through the

conduct of world-class, innovative translational research that

leads to discoveries – and ultimately cures – for metabolic

diseases.

Scope: Translational research focused on metabolism,

diabetes, and the metabolic origins of cardiovascular

diseases

15

Innovate. Discover. Cure.

Sanford-Burnham Florida Hospital Translational Research Institute

Translational Research

Discovery

Research

Step 1

Translational

Research

Step 2

Translational

Research

Clinical

Practice

Basic

Knowledge

Pre-clinical

testing

Proof-of-

Concept

Target validation

Is the treatment

safe and

effective?

Implementation

of best

practices

The Translational Research Institute

Facilities Overview

54,000 sq feet of dedicated

clinical research space on the

FL Hospital campus

Floor 1: Clinical, Imaging and

Administrative Core Facilities

Floor 2: CRU, Metabolism and

Energy Expenditure Core,

Research Pharmacy,

Laboratory-Biorepository

Floor 3: Shelled for future

growth

650 kW backup power

PI Resources

Dedicated office and

administrative space

Shared research staff

(coordinators, core experts,

stats & database)

Privileges to TRI and SBMRI

Core Facilities 18

TRI

Deep Phenotyping Energy expenditure

Indirect calorimetry

Doubly labeled water

Glucose, fat, and muscle metabolism Emphasis on exercise testing and

mitochondrial bioenergetics

In-situ biochemistry (MRS) Energy, 31P

Lipid, 1H

Food (energy and macronutrient) intake

Body composition

Endocrine testing / PK

Biomarker Discovery and Development

Approaches Disease pathobiology

Clinical Trials

Experimental medicine Target validation

Segmentation/Differentiation

Biopsy-based PD / biomarker development and validation Adipose and skeletal muscle

Leverage relationship with SBMRI

PoC / PoM studies Industry sponsored

Co-developed protocols

IIT

19

TRI Research / Technology Cores

Clinical Operations Research Clinic

Research Administration

Clinical Research Unit Research Pharmacy

Metabolic Kitchen

Energy Metabolism Hood and whole-room

calorimetry

Imaging DXA

MRI/MRS

Research CTMS, eCRFs, Database and Biostatistics

Laboratory 1. Clinical Laboratory

(Florida Hospital Lab)

2. Biorepository

3. Biomarker Discovery and Development Laboratory (links to SBMRI)

Industry Partners

20

TRI Faculty Scientists

Richard Pratley, MD

Diabetes Pathobiology

and Therapeutics

Dwight Towler, MD

Vascular Biology

21

Magdalena Pasarica,

MD, PhD

Obesity

Victor Herrera, MD

Gut Microbiome in

Metabolic Diseases

Lauren Sparks, PhD

Muscle Metabolism

Attila Seyhan, PhD

Biomarkers and

RNA Metabolism

TRI Research Scientists

Adeline Divoux, PhD

Postdoctoral Fellow

Obesity

Zuzana Kovacova, PhD

Postdoctoral Fellow

Diabetes

Heather Cornnell, PhD

MR Physics and

Bioengineering

Stephanie Parsons, PhD

Research Scientist

Skeletal Muscle

Hui Xie, PhD

BioStatistics /

BioInformatics

Alok Pachori, PhD

Research Scientist

Biomarkers

Rebecca Zuvich, PhD

Postdoctoral Fellow

Personalized Medicine

Chris Davis, PhD

Research Scientist

Industry Alliances

22

TRI Operations and Administration

Regina Tan, MBA

Grants and Contracts

Manager

23

Jan Holladay Pierre, MPH

Quality and Audit

Compliance Manager

Karen Potter Jones, RN

Clinical Operations

Manager

Penny Carlson, RN

Clinical Operations

Manager

Julie Clyatt, ARNP

Nurse Practitioner

Jennifer McCall, MS

Laboratory Manager

Shelly Crunk, MBA

Director of Finance-

Research

Sabrina Gmerek-Pettus,

ARNP

Nurse Practitioner

Clinical Operations • 12 exam rooms

• Phlebotomy in clinic

• Bariatric design elements

• Adjacent to imaging

BioImaging Core

DEXA (body composition)

Proton MRS

Muscle and hepatic lipid

Cardiac

3T research dedicated MRI / MRS

Multi-nuclear: 1H, 31P, 13C

Optical spectroscopy (muscle O2) 31P

muscle

Echocardiography - planned

26

Clinical Research Unit (CRU) • Hotel design features

• Nursing unit

• 8 rooms (10 beds) for

overnight stays

• 3 Procedure rooms

• Exercise testing suite

• Recreation areas

including outside patio

• Research Pharmacy

• Supports Energy

Expenditure and

Metabolism Core

• Initially prn

eventually 24 - 7

27

Metabolic Kitchen Supports:

• CRU

• Calorimetry

• Diet intervention studies

• Equipped for inpatient and

outpatient studies

• Dining room

• Walk-in cooler and freezer

• Dry storage

Resting metabolic rate /

pharmacodynamic room 1

Resting metabolic rate /

pharmacodynamic room 2

Instru

men

t roo

m

Exterior glass wall (east)

Room

calorimeters

Room Calorimeters

Two 30,000L calorimeters

• “push-pull” air flow

• 5oC - 38oC temperature

control

• Full digital datastream

• Best-in-class accuracy

Two 3kL – 5kL calorimeters

• Convertible from bed

(3kL) to small room format

(5kL)

• Exercise testing (bike)

• RMR / RQ

• PK / PD

● Regional differences in adipose gene expression

● Alt. RNA splicing [muscle] across a range of metabolic

phenotypes

● Developing oxidative and glycolytic cell lines

● Orexin A as a treatment for obesity

● BNP as a treatment for obesity and hypertension

Active Collaborative Studies with S|B

Scientists

TRI

www.TRI-MD.org

/ TRIMDorg iPad app