ribozymes (rna enzymes) david peterson. enzymes catalyze reactions very specific act on substrates...
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Ribozymes(RNA Enzymes)
David Peterson
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Enzymes•Catalyze reactions
•Very specific
•Act on substrates
•Active site
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Enzymes Bind Substrates
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Enzymes Bind Substrates
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Enzymes Bind Substrates
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Structure of RNA and DNA
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DNA RNA Protein
Information Flow in CellsThe Central Dogma of Molecular Biology
Transcription Translation
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Semiconservative DNA Replication
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Amino acids combine to make peptides and proteins
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mRNA Splicing
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Ribosomes
• Site of protein synthesis
• Made of RNA and protein
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Tetrahymena thermophila
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Self-Splicing RNA
Cech, Zaug, and Grabowski.1981. Cell 27: 487-496
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Single-Stranded RNA Can Form Intramolecular Base Pairs
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Intramolecular H-bonds in the Tetrahymena Ribozyme
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3D Structure of the Self-Splicing Intron
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Ribosomes
• Site of protein synthesis
• Made of RNA and protein
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Tom Cech Sidney Altman
Nobel Prize in Chemistry 1989