rheumatic fever - univerzita karlova rheumatic fever rheumatic fever is an inflammatory disease...

Rheumatic fever - Univerzita Karlova Rheumatic fever Rheumatic fever is an inflammatory disease which
Rheumatic fever - Univerzita Karlova Rheumatic fever Rheumatic fever is an inflammatory disease which
Rheumatic fever - Univerzita Karlova Rheumatic fever Rheumatic fever is an inflammatory disease which
Rheumatic fever - Univerzita Karlova Rheumatic fever Rheumatic fever is an inflammatory disease which
Download Rheumatic fever - Univerzita Karlova Rheumatic fever Rheumatic fever is an inflammatory disease which

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  • Rheumatic fever

    Rheumatic fever is an inflammatory disease which

    may develop after a Group A streptococcal infection

    (such as strep throat or scarlet fever) and can involve

    the heart, joints, skin, and brain.

    It commonly appears in children ages 5 through 15 . Pathophysiology

    Rheumatic fever is a systemic disease affecting the peri-

    arteriolar

    connective tissue and can occur after an untreated Group A

    streptococcal pharyngeal infection. It is believed to be

    caused by antibody cross-reactivity.

    http://en.wikipedia.org/wiki/Inflammatory_disease http://en.wikipedia.org/wiki/Disease http://en.wikipedia.org/wiki/Group_A_streptococcal_infection http://en.wikipedia.org/wiki/Strep_throat http://en.wikipedia.org/wiki/Scarlet_fever http://en.wikipedia.org/wiki/Heart http://en.wikipedia.org/wiki/Joint http://en.wikipedia.org/wiki/Skin http://en.wikipedia.org/wiki/Brain http://en.wikipedia.org/wiki/Cross-reactivity http://en.wikipedia.org/wiki/Cross-reactivity http://en.wikipedia.org/wiki/Cross-reactivity

  • Major criteria Joints (Migratory polyarthritis): a temporary migrating inflammation

    of the large joints, usually starting in the legs and migrating upwards.

    O [imagine heart-shaped O] (Carditis): inflammation of the heart

    muscle which can manifest as congestive heart failure with

    shortness of breath, pericarditis with a rub, or a new heart murmur.

    Nodules (subcutaneous nodules - a form of Aschoff bodies):

    painless,firm collections of collagen fibers on the back of the wrist,

    the outside elbow, and the front of the knees. These now occur

    infrequently.

    Erythema marginatum: a long lasting rash that begins on the trunk

    or arms as macules and spread outward to form a snakelike ring

    while clearing in the middle. This rash never starts on the face and

    is made worse with heat.

    Sydenham's chorea (St. Vitus' dance): a characteristic series of rapid

    movements without purpose of the face and arms. This can occur

    very late in the disease.

    http://en.wikipedia.org/wiki/Arthritis http://en.wikipedia.org/wiki/Congestive_heart_failure http://en.wikipedia.org/wiki/Pericarditis http://en.wikipedia.org/wiki/Heart_murmur http://en.wikipedia.org/wiki/Aschoff_bodies http://en.wikipedia.org/wiki/Erythema_marginatum http://en.wikipedia.org/wiki/Macule http://en.wikipedia.org/wiki/Sydenham%27s_chorea http://en.wikipedia.org/wiki/Sydenham%27s_chorea http://en.wikipedia.org/wiki/Sydenham%27s_chorea

  • Minor criteria Fever: temperature elevation

    Arthralgia: Joint pain without swelling

    Laboratory abnormalities: increased Erythrocyte

    sedimentation rate, increased C reactive protein, leukocytosis

    Electrocardiogram abnormalities: a prolonged

    PR interval

    Evidence of Group A Strep infection: positive

    culture for Group A Strep,

    elevated or rising Antistreptolysin O titre

    Previous rheumatic fever or inactive heart disease

    http://en.wikipedia.org/wiki/Fever http://en.wikipedia.org/wiki/Arthralgia http://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate http://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate http://en.wikipedia.org/wiki/Erythrocyte_sedimentation_rate http://en.wikipedia.org/wiki/C_reactive_protein http://en.wikipedia.org/wiki/Leukocytosis http://en.wikipedia.org/wiki/Electrocardiogram http://en.wikipedia.org/wiki/Antistreptolysin_O_titre

  • Treatment

    1.The management of acute rheumatic fever is

    geared toward the reduction of inflammation with

    anti-inflammatory medications such as aspirin or

    corticosteroids.

    2.Individuals with positive cultures for strep throat

    should also be treated with antibiotics.

    3.Another important cornerstone in treating

    rheumatic fever includes the continual use of low

    dose antibiotics (such as penicillin, sulfadiazine,

    or erythromycin) to prevent recurrence.

    http://en.wikipedia.org/wiki/Anti-inflammatory_medication http://en.wikipedia.org/wiki/Anti-inflammatory_medication http://en.wikipedia.org/wiki/Anti-inflammatory_medication http://en.wikipedia.org/wiki/Aspirin http://en.wikipedia.org/wiki/Corticosteroid http://en.wikipedia.org/wiki/Antibiotic http://en.wikipedia.org/wiki/Penicillin http://en.wikipedia.org/wiki/Sulfadiazine http://en.wikipedia.org/wiki/Erythromycin