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Revolutionary Laminar Flow TechnologyIn Triple Quadrupole Mass Spectrometry
SENSITIVITY
Low femtogram level detection. Effi-cient laminar flow interface (HSIDTM Ultra), laminar flow ion guides, and five-stage pumping direct ions into the mass spectrometer at any given flow rate with minimum losses.
EASE OF USE
“Go with the flow” provides optimum performance with minimal optimiza-tion and tuning. Carried by gas flow, ion tuning is quick and accurate.
RUGGEDNESS
Minimal susceptibility to system instabilities, and greatly improved signal stability and reproducibility, by reducing any line of sight con-tamination.
TORRENTTM COAXIAL FLOW ION SOUCE
Proprietary geometry provides efficient desolvation, vaporization and ion entrainment for a high yield of ion production and trans-fer for ESI and APCI.
Creating a New Horizon in Design
and Engineering for LC/MS/MS
Revolutionary System ArchitectureIn Triple Quadrupole Mass Spectrometry
SMALL FOOTPRINT
Innovative vertical orientation with base of 50x50 cm increases your useful lab space.
SYSTEM RELIABILITY
A common interconnect backplane minimizes connectors and cabling by more than 80%, increasing system robustness.
EASE OF SERVICE
Full system modularity provides component by component plug and play, including the FlowTuneTM Ion Path, dramatically improving serviceability, reducing service downtime and cost.
Revolutionary SyIn Triple Qu
SMALL FO
Innovative vertwith base of 50your useful lab
SYSTEM R
A common inteminimizes connby more than 8system robustn
EASE OF S
Full system mocomponent by and play, includIon Path, dramserviceability, rdowntime and
Data Acquisition and Processing Software State of the Art Quantitation
Developed for IONICS by Phenomenome Dis-coveries of Saskatoon, Canada, MolAna is a complete data acquisition and quantitation pack-age that is designed to work in today’s multi-instrument, multi-vendor laboratory environ-ments.
Easy to use and intuitive, MolAna has a user-friendly, workflow oriented interface and simple method setup. MolAna provides efficient quantita-tion, with fast and reliable curve fitting and integra-tion; has import/export capabilities; and many other advanced and automated features for efficient data processing.
Designed for chromatographers, MolAna provides full data acquisition capability, including multiple overlapping experiments within the same method.
MolAna introduces the universal quantitation package that enables users to extract and perform quantitation for data collected in virtually any analysis mode.
Multiple overlapping experiment method editorManual Tuning preview window
Quantitation method creation Standard calibration curve
er-mpletita-gra-any for
tionand ally
Acetaminophen, a commonlyused analgesic (pain reliever)and antipyretic (fever reducer)was analyzed. It is a challenging compound to run by mass spec-trometry as a result of its lowmolecular weight (151) andfragility. It was run in the positive ion mode by electrospray usingMRM mode monitoring of152/110.
The HPLC separation was accomplished at the flow rate of 200ul/min by employing25/37.5/37.5 water/acetonitrile/methanol with 0.1% formic acid using a Beta Basic C18 2.1 X 50 mm 3micron column injecting 5ul. The signal to noise, based on 3 sigma, was 36/1 on the 50 fg/ul injection. The concentration range run shows excellent linearity.
The transition 609 to195 wasmonitored using MRM. Thesignal to noise is better then90:1. Here a 5 microliter injec-tion volume is used. The chro-matographic conditions were3/7 water/Acetonitrile 2mMammonium acetate with 0.1%formic acid at a flow of 0.2milliliter per minute.
Pow
erfu
l Flo
wTu
neTM
Ion
Path
Usi
ng L
amin
ar F
low
Sam
plin
g Te
chno
logy
and
a F
ive-
Stag
e Pu
mp
ing
Syst
emp
ing
Syst
em
Torr
entTM
Ion
Sour
ce S
ingl
e or
dua
l spr
ay s
ourc
e fo
r on
e or
bot
h of
ES
I/ES
I; A
PC
I/ES
I; A
PC
I/AP
CI
usin
g pr
oprie
tary
ge
omet
ry
for
max
imum
ene
rgy
trans
fer
and
ion
entra
inm
ent.
Torr
ent
prov
ides
hig
h se
nsiti
vity
for a
wid
e flo
w ra
te ra
nge
and
flex-
ibili
ty fo
r bot
h w
orkh
orse
and
hig
h th
roug
hput
app
licat
ions
.
Pat
ente
d m
ulti-
orth
ogon
al
HS
IDTM
te
chno
logy
com
bine
d w
ith e
nhan
ced
flow
(H
SID
Ultr
a) fo
r sm
ooth
tran
sfer
of
ion
s fro
m t
he i
on s
ourc
e to
the
m
ass
spec
trom
eter
, w
ith
min
imum
lo
sses
, low
er c
hem
ical
noi
se, a
nd n
o ne
ed fo
r opt
imiz
atio
n.
Hig
h pe
rform
ance
qua
drup
ole
rods
with
pro
prie
tary
m
anuf
actu
ring
appr
oach
pro
vide
s ex
celle
nt t
rans
-m
issi
on a
t un
it an
d hi
gh r
esol
utio
n, o
fferin
g hi
gher
le
vel o
f sel
ectiv
ity a
nd d
etec
tion.
Pat
ent
Pen
ding
Lam
inar
Flo
w I
on G
uide
sTM p
erm
it th
e sm
ooth
tra
nsfe
r of
ions
thr
ough
var
ious
sta
ges
of p
umpi
ng w
ith m
inim
al
tuni
ng,
whi
le a
lso
redu
cing
mas
s di
scrim
inat
ion,
che
mic
al n
oise
, an
d pr
ovid
ing
a flo
w d
riven
axi
al m
otio
n fo
r fas
t sca
nnin
g. Pat
ent
Pen
ding
Hig
h E
ffici
ency
Col
lisio
n C
ell w
ith a
xial
fiel
d, p
rovi
ding
for u
ltra
fast
sc
an s
peed
and
min
imal
cro
ss i
nter
fer-
ence
.
Pat
ent
Pen
ding
Uni
Fiel
dTM I
on D
etec
tor
with
ultr
a fa
st c
harg
e se
lect
ion,
per
mitt
ing
for d
etec
tion
of n
egat
ive
and
posi
tive
ions
w
ithou
t H
V p
olar
ity s
witc
hing
, an
d ac
cu-
rate
out
put
at h
igh
coun
t ra
tes
for
high
dy
nam
ic ra
nge.
ION SOURCE
ION SOURCE TYPE
FLOW RATES
SOFTWARE
DIMENSIONS
WARRANTY
TorrentTM Single or Dual Probe
ESI/APCI
5 uL/min 3 mL/min
MolAna 1.0 software
50 cm L, 50 cm W, 110 cm H
3 Years
SENSITIVITY
SCAN SPEED
MRM SPEED
MASS RANGE
DYNAMIC RANGE
POLARITY SWITCHING SPEED
DETECTOR
Low femtogram levels
5000 Da/s
<5ms dwell time/pause time
5-1500 m/z
5 orders of magnitude
Ion formation dependent
UniFieldTM high dynamic range
ultrafast detection
SPECIFICATIONS
Research use only. Information, descriptions and specifications in this publication are subject to change without notice.
IONICS Mass Spectrometry Group shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing, performance or use of this material.
*IONICS 3Q Molecular Analyzer , MolAna Software, Torrent Ion Source, FlowTune Ion Path, HSID Ultra and UniField Ion Detector are the trade marks of IONICS Mass Spectrometry
Group, Inc.
IONICS Mass Spectrometry Group, Inc.1-32 Nixon Road, Bolton , ON L7E 1W2 , Canada; 905-857-5665 x 226; Fax 905-857-3040; [email protected]; www.ionics.ca
Ionics MSE Eastern US, 14408 Kings Grant, Gaithersburg , MD 20878 , USA ; Phone: 301-461-0259; Fax: 240-328-6858; [email protected]; www.ionicsmse.com
Ionics MSW Western US, 7329 Gabbiano Lane, Carlsbad , CA 92011 , USA ; Phone: 760-815-9611; [email protected]; www.ionics.ca
Ionics MSV Europe, Antennestraat 14, 1322 AB Almere, The Netherlands; Phone: +31 36 5468 755; Fax: +31 36 5468 756; [email protected]; www.ionicsmsv.eu
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