resistance 15 · introduction page 3 programme page 4,5 conference information page 6,7 biographies...

Executive Chair: Honorary Chair:

Professor Anna Maria Geretti Professor Jonathan WeberUCL Medical School, London Imperial College Londonand University of Liverpool

Thursday 29 September 2011

Royal College of PhysiciansRegent’s Park · London

Early R

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Deadline

30 J

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2010

6 C

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67470

HIV AS A VIROLOGICAL

PARADIGM

HIV AS A VIROLOGICAL

PARADIGM

15th Annual Resistance andAntiviral Therapy Meeting

15th Annual Resistance andAntiviral Therapy Meeting

Gold Sponsor

Resistance15th

Annual MeetingResistance

15th


15th

Annual Meeting

FINAL PROGRAMME

Contents

Introduction Page 3

Programme Page 4,5

Conference Information Page 6,7

Biographies Page 8,9

Sponsors Page 10

Event Diary Page 11

Your delegate badge must be worn at all times in order to gain access to all events and facilities

Venue and Locations: Royal College of Physicians

Lecture Theatre Seligmann Theatre, Ground Floor

Exhibition Platt Room, Ground Floor

Lunch and Refreshments Platt Room, Ground Floor

Registration Lower Hall, Ground Floor

6 CPD Credits Unique reference number: 67470

2 Conference Organiser: t: 020 8446 8898 · f: 020 8446 9194 · e: [email protected] · www.mediscript.ltd.uk

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Scientific Committee

Dr Marta Boffito Chelsea and Westminster Hospital, London

Professor Pat Cane Health Protection Agency, London

Dr David Dunn MRC Clinical Trials Unit, London

Professor Geoff Dusheiko UCL Medical School andRoyal Free Hampstead NHS Trust, London

Professor Graham Foster Queen Mary, University of London

Professor Anna Maria Geretti University College London Medical SchoolExecutive Chair and University of Liverpool

Professor William Irving University of Nottingham

Professor Saye Khoo University of Liverpool

Professor Andrew Leigh Brown University of Edinburgh

Professor Andrew Phillips University College London Medical School

Professor Deenan Pillay University College London Medical School

Professor Jonathan Weber Honorary Chair Imperial College London

mailto:[email protected]

http://www.mediscript.ltd.uk

Introduction

Dear Colleague

Welcome to the 15th Annual Resistance and Antiviral Therapy Meeting at the

Royal College of Physicians, which can comfortably accommodate our numbers and

provide all the facilities required for our delegates.

We would like to thank our colleagues on the Scientific Committee for their efforts in preparing

an excellent programme, covering a very wide range of topics. The programme will focus on

developments in the field of antiretroviral resistance and will also include updating and feeding

back recent data on antiviral therapy in HIV, hepatitis B and hepatitis C, and the challenges that

still lie ahead. In addition, we are happy to be able to include, once again, a session in

collaboration with the UK HIV Drug Resistance Database Group and we feel sure this session will

prove to be very topical as well as raise some interesting points for debate and discussion.

We are especially delighted that a number of eminent speakers have agreed to come to London

to share their latest research. Our international speakers include Dr Francesca

Ceccherini-Silberstein, Dr William Delaney, Dr Brooke Nichols and Dr Roger Paredes. We would

like to thank all of our speakers for their invaluable contribution in helping to make the

conference, what we hope will be, a great success.

The Scientific Committee has made arrangements this year to offer reduced registration rates for

students and non-consultants in training and to freeze all other registration rates for the third

successive year, which has enabled more delegates to register for the conference. In addition, a

number of scholarships have been made available to assist those with financial constraints to

attend the conference.

Finally, we would like to thank all our sponsors and exhibitors for their continued support of

the Conference, which, in part, enables us to facilitate the attendance of a number of international

speakers.

We very much hope you will enjoy the conference and will find it of relevance to both your

educational and practical needs.

Professor Anna Maria Geretti Professor Jonathan WeberExecutive Chair Honorary Chair

3Conference Organiser: t: 020 8446 8898 · f: 020 8446 9194 · e: [email protected] · www.mediscript.ltd.uk

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Programme

HIV AS A VIROLOGICAL PARADIGMHIV AS A VIROLOGICAL PARADIGM

Thursday 29 September 2011

Royal College of Physicians · 11 St Andrews Place · Regent’s Park · London NW1 4LE

0815–1545 Registration and exhibition open

0855–0900 IntroductionProfessor Jonathan Weber, Imperial College London

Professor Anna Maria Geretti, University College London Medical Schooland University of Liverpool

The Educational Session

Chair: Dr Mark Atkins, Imperial College Healthcare NHS Trust, London

0900–0930 Hepatitis delta: often forgotten?Dr Sarah Hughes, King’s College Hospital, London

0930–1000 Clinical case: challenges in antiviral therapyDr Sanjay Bhagani, Royal Free Hospital, London

1000–1010 Panel discussion

The Update and Feedback Session

Chairs: Professor Jane Anderson, Homerton University Hospital, London

Chairs: Professor Margaret Johnson, Royal Free Hospital, London

1010–1040 Five papers that have changed clinical practice in 2010–2011Professor Anna Maria Geretti, University College London Medical Schooland University of Liverpool

1040–1050 Discussion

1050–1110 Morning coffee

Plenary Session 1: Antiretroviral drug resistance

Chairs: Dr Marta Boffito, Chelsea and Westminster Hospital, London

Chairs: Professor Jonathan Weber, Imperial College London

1110–1140 PrEP: a drug resistance perspectiveDr Brooke Nichols, Erasmus Medical Centre Rotterdam, The Netherlands

1140–1210 The clinical impact of low-frequency NNRTI-resistant mutantsDr Roger Paredes, University Hospital Germans Trias i Pujol, Barcelona, Spain


1220–1315 Lunch

The Scientific Committee would like to extend grateful thanks to the Gold Sponsorof this Meeting for providing an educational grant in support of the programme


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Programme

Invited Lecture 1

Chairs: Professor Pat Cane, Health Protection Agency, London

Chairs: Professor Andrew Leigh Brown, University of Edinburgh

1315–1330 Incident HIV infection in the UKDr Valerie Delpech, Health Protection Agency, London

1330–1340 Discussion

The UK HIV Drug Resistance Database Abstract Session

Chairs: Professor Pat Cane, Health Protection Agency, London

Chairs: Professor Andrew Leigh Brown, University of Edinburgh

1340–1350 The role of recent infection in driving the UK HIV-1 epidemicMr John Ambrose, Royal Free Hospital, London

1350–1400 Viral determination of rate of progression in HIV infectionMs Emma Hodcroft, University of Edinburgh

1400–1410 Latest trends in transmitted drug resistance in the UKMr David Dolling, MRC Clinical Trials Unit, London

1410–1420 Persistence of transmitted resistance mutationsDr David Dunn, MRC Clinical Trials Unit, London


Invited Lecture 2

Chair: Professor Anna Maria Geretti, University College London Medical Schooland University of Liverpool

1430–1440 UNAIDS and the role of virological evidence in the criminalisation of HIVtransmissionDr Yusef Azad, National AIDS Trust


Keynote Lecture

Chair: Professor Jonathan Weber, Imperial College London

1450–1520 Does HIV-1 uncoat at the nuclear pore as part of nuclear entry?Professor Greg Towers, University College London

1520–1545 Afternoon tea

Plenary Session 2: New challenges in antiviral drug resistance

Chairs: Professor William Irving, University of Nottingham

Chairs: Dr William Tong, Guy’s and St Thomas’ NHS Foundation Trust, London

1545–1615 Second-generation integrase inhibitors: is cross-resistance a threat?Dr Francesca Ceccherini-Silberstein, University of Rome, Italy

1615–1645 Direct-acting antiviral agents against hepatitis C: is resistance a threat?Dr William Delaney, Gilead Sciences, USA


1700 CloseProfessor Anna Maria Geretti, University College London Medical School

and University of Liverpool

Professor Jonathan Weber, Imperial College London


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Conference Information

Registration procedure

The registration fee includes access to all scientific sessions, the exhibition areas, lunch andrefreshments throughout the conference.

Continuing Professional Development (CPD)

Medical staff in career-grade posts who are enrolled with one of the Royal Medical Colleges forContinuing Professional Development can receive CPD credits at the rate of one CPD credit perhour (exclusive of travel, refreshments or social activities). The conference has been allocated 6CPD credits with the unique reference code: 67470. Certificates for attendance will be supplied inthe conference pack that will be handed to you at the registration desk.

Scholarships

Community Registration Places have been allocated to delegates attending the conference, on thebasis of a maximum of one free-of-charge registration per community group.

Student Registration Scholarships The conference has supported the registrations of fivedelegates, who are either students or of training grade, to attend the 15th Annual Resistanceand Antiviral Therapy Meeting. These awards were made available to delegates who, throughtheir applications, clearly showed they had financial constraints that would otherwise haveprevented them from attending the conference.

Accommodation

There are a number of hotels near the conference centre offering accommodation. If you requireassistance please contact the Conference Organiser for further details of hotels in the vicinity of theconference venue.

Conference venue

Royal College of Physicians11 St Andrews Place, Regent’s Park, London NW1 4LE

Telephone: +44 (0)20 7935 1174 · www.rcplondon.ac.uk

The conference venue is a short walk from Regent’s Park and Great Portland Street Undergroundstations. Please see the map opposite for the location of these stations in relation to the College.

There are also good links to the city centre from both Heathrow and Gatwick airports. Journeysby either Heathrow or Gatwick Express take about an hour.

There are car parks near to the conference venue. Contact the NCP for details.

The conference venue is located outside the London congestion charge zone. The College is in aconvenient and attractive location in the centre of London, easily accessible by all forms oftransport. The main entrance and reception face Regent’s Park.


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http://www.rcplondon.ac.uk



Conference Information

Travelling to the College

By Underground:

• Regent’s Park station on theBakerloo line (3 minutes’ walk)

• Great Portland Street station on theCircle, Metropolitan and City lines(5 minutes’ walk)

• Warren Street station on the Victoriaand Northern lines (10 minutes’walk)

By Train:

• Euston station (15 minutes’ walk)

By Air:

• Heathrow: Express train fromHeathrow airport(15 minutes toPaddington station, thenthree stops on theUnderground [Circle Line] to Great Portland Street station)

• Gatwick: Express train from Gatwick airport (30 minutes to Victoria station, then threestops on the Underground [Victoria Line] to Warren Street station)

• Stansted: Express train from Stansted airport (45 minutes to Liverpool Street, then fivestops on the Underground [Circle Line] to Great Portland Street station)

Useful Contacts


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Royal College of Physicians

General

Transport for London (24hr) 020 7222 1234www.tfl.gov.uk

Air travel

Heathrow Airport 0870 000 0123www.baa.com/main/airports/heathrow

Gatwick Airport 0870 000 2468www.baa.com/main/airports/gatwick

Luton Airport 01582 405 100www.london-luton.co.uk

Stansted Airport 0870 000 0303www.baa.com/main/airports/stansted

Rail travel

National Rail info/reservations 0845 748 4950www.nationalrail.co.uk

Eurostar trains 0870 518 6186www.eurostar.com

Heathrow Express 0845 600 1515www.heathrowexpress.co.uk

Gatwick Express 0870 530 1530www.gatwickexpress.co.uk

Bus and coach travel

National Express coaches 0870 580 8080www.nationalexpress.com

Eurolines 0870 514 3219www.eurolines.com

Road travel

NCP 0870 606 1050www.ncp.co.uk

Congestion charging 0845 900 1234www.cclondon.com

The Royal College of Physicians is located outside the London congestion charge zone

Taxis: London Dial-a-Ride 020 7266 6100

National Cab Line 0800 123 444



http://wwwffl.gov.uk

http://www.baa.com/main/airports/stansted

http://www.baa.com/main/airports/gatwick

http://www.london-luton.co.uk

http://www.baa.com/main/airports/stansted

http://www.nationalrail.co.uk

http://www.eurostar.com

http://www.heathrowexpress.co.uk

http://www.gatwickexpress.co.uk

http://www.nationalexpress.com

http://www.eurolines.com

http://www.ncp.co.uk

http://www.cclondon.com

Biographies

John Ambrose is a PhD student in the Virology Department of University College London Medical School. Hisstudies currently focus on the molecular epidemiology of HIV-1 in high- and low-prevalence settings, withparticular emphasis on recent infection and transmitted drug resistance.

Yusef Azad is Director of Policy at NAT (the National AIDS Trust), the UK’s HIV policy organisation. He hasbeen at NAT since 2004 and previously worked as a parliamentary official, advising and supporting selectcommittee inquiries. In addition to his work at NAT, Yusef co-chairs the EU’s HIV Civil Society Forum, whichadvises the European Commission on HIV policy. He has written, presented and published on a wide range ofHIV issues, such as criminalisation of HIV transmission, equality and discrimination issues, and new approachesto HIV testing.

Sanjay Bhagani is a consultant physician in infectious diseases/HIV medicine and general (internal) medicine atthe Royal Free Hospital, London. He has a sub-specialty interest in managing patients with HIV and hepatitisco-infection and has served on the HIV/hepatitis co-infection management guidelines committees of EACS andBHIVA. He is committed to education and training in HIV medicine for doctors in the developing world and hasbeen involved in delivering training programmes in East Africa and the Indian sub-continent. He is passionateabout fostering further educational links with the developing world.

Francesca Ceccherini-Silberstein is assistant professor to the Chair of Virology, Department of ExperimentalMedicine, University of Rome ‘Tor Vergata’. She obtained her PhD in Biology at the University of Munich inGermany, in 2001. Since 2005, she has been Professor of Virology at the Science Faculty, University of L’Aquila,Italy. Her group undertakes research on HIV/HBV/HCV drug-resistance, HIV pathogenesis, viral tropism, viralevolution, genotypic, structural and functional analysis of viral proteins. She has published 66 full papers inprestigious journals, with an impact factor of >200.

William E Delaney IV is a director in Gilead’s Biology Department where he oversees antiviral discovery researchfor hepatitis B and C viruses. Prior to joining Gilead, Dr Delaney earned his PhD in Cell & Molecular Biologyat the Penn State College of Medicine, Pennsylvania, USA and trained as a postdoctoral fellow with Dr StephenLocarnini at the Victorian Infectious Diseases Reference Laboratory in Melbourne, Australia.

Valerie Delpech is a public health consultant epidemiologist at the Health Protection Agency and has led on thenational surveillance of HIV infections for the United Kingdom for the past 5 years. She trained in medicine andpublic health in Australia and the UK and has extensive experience in communicable disease control and publichealth, with a particular interest in sexual health. Valerie serves on a number of national and internationalcommittees in relation to HIV surveillance, prevention and policy development. She provides scientific supportto the English Expert Advisory Group on AIDS (EAGA) and was a member of the writing committee of the UKNational Guidelines for HIV Testing 2008. Valerie is an executive trustee for the National AIDS Trust. Valerie’sresearch interests and publications have focused on better understanding changes in the epidemiology of HIV,STIs and HIV co-infections, and tracking efforts to curb these epidemics in vulnerable populations.

David Dolling After completing his Masters in Biometry in 2010, David began working as a medical statisticianon the UK HIV Drug Resistance Database at the Medical Research Council’s Clinical Trials Unit in London.

David Dunn is a senior statistician in the HIV Group at the MRC Clinical Trials Unit. Previously he worked at theLondon School of Hygiene and Tropical Medicine in various areas of infectious disease epidemiology and at theInstitute of Child Health where he worked primarily on mother-to-child transmission of HIV and toxoplasmosis.His current interests include antiretroviral drug resistance, therapeutic drug monitoring, the use of laboratorymarkers to monitor HIV infection, and the design and conduct of strategic clinical trials.


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Biographies

Anna Maria Geretti is Professor of Virology & Infectious Diseases and Honorary Consultant at the Institute ofInfection & Global Health, and Visiting Professor at the London Centre for Nanotechnology, University CollegeLondon, where she consults on virus infections, sees patients with HIV or chronic viral hepatitis, teaches andconducts research. She trained in Italy, the Netherlands and the UK, is an elected member of the EACS ExecutiveCommittee, and contributes to educational and scientific activities of EACS, BHIVA, BASHH and IUSTI/ WHO,including the development of practice guidelines. She has edited a book on antiretroviral resistance and publishedover 100 peer-reviewed articles. She enthusiastically shares her expertise to train doctors and scientists, and runscapacity building programmes for resource-limited countries.

Sarah Hughes completed her training at the University of Cambridge Medical School in 1999. She joined theSouth East Thames Specialist Registrar training scheme in Gastroenterology in 2003. She is currently a clinicalresearch Fellow at King’s College Hospital, where she has developed a special interest in hepatitis delta virus. Herresearch, under the supervision of Dr Phil Harrison, is investigating the role of innate immunity in the clearanceof delta virus. She recently published a review on the subject of HDV in The Lancet.

Emma Hodcroft completed her MSc in Quantitative Genetics and Genome Analysis at the University of Edinburgh,graduating with distinction. She now studies the genetic influence of disease progression in HIV with ProfessorAndrew Leigh Brown in Edinburgh and will be beginning her PhD in September to continue this work.

Brooke Nichols is a PhD student in the Department of Virology at the Erasmus Medical Centre in Rotterdam. Aftera Masters degree in Epidemiology at the University of Massachusetts, Amherst, she focused on HIV mathematicalmodelling. She is currently studying the medical prevention of HIV with regard to the development of drugresistance, specifically in the context of test and treat and pre-exposure prophylaxis.

Roger Paredes is attending physician at the HIV Unit, Hospital Universitari Germans Trias i Pujol, in Barcelonaand Head of the Molecular Epidemiology Group at the IrsiCaixa Retrovirology Laboratory. Dr Paredes hasmade key contributions to the current understanding of the clinical relevance of minority HIV-1 resistant variants.

Greg Towers was awarded a BSc (hons) in Biochemistry from the University of Surrey in 1991 and a PhD fromthe University of London in 1995 after working on HIV-1 transcription in the lab of Mary Collins at the Instituteof Cancer Research. He did a post doc at the National Institute of Medical Research with Jonathan Stoye workingon the mouse antiviral protein Fv1. This work continued at the Gene Therapy Institute Genethon in France withOlivier Danos. Greg moved to UCL in 1999 and was awarded a Wellcome RCDF in 2001. During this time hewent on sabbatical to Steve Goff’s lab in Columbia University in New York. Greg is now Professor of MolecularVirology in the Department of Infection at UCL and a Wellcome Senior Research Fellow.

Jonathan Weber trained in Cambridge and, via St Mary’s Hospital Medical School, the Institute of CancerResearch and the Royal Postgraduate Medical School, established the Department of GUM and CommunicableDiseases at Imperial College London, endowed by the Jefferiss Trust, in 1991. This department houses adedicated clinical research facility for HIV and HTLV patients, and was heavily involved in the clinicaldevelopment of combination antiretroviral therapy for the treatment of HIV infection from 1991–1996. Jonathanis the Chair of the Microbicides Development Programme (2001–2011), an MRC/DfID funded project to developa vaginal microbicide, and is the Principal Investigator of the Wellcome Trust funded ‘Spartac’ randomisedclinical trial of short-course therapy at primary HIV infection, which will report in 2011. He is also the ClinicalLead for the EuroVacc Foundation and jointly conducted the EV01, 02 and 03 HIV vaccine DNA/poxprime-boost trials. Jonathan currently leads the Wellcome Trust funded UK HIV Vaccine Consortium.


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Sponsors

Gold Sponsor

The Scientific Committee would like to extend grateful thanksto the Gold Sponsor of this Meeting for providing an educational grant

in support of the programme

MSD Limited

Hertford RoadHoddesdonHertfordshire EN11 9BU

The Scientific Committee also wish to express their thanks to the following companiesfor their generous support:

Bronze Sponsors

Gilead Sciences Limited

Granta ParkGreat AbingtonCambridgeshire CB21 6GT

Janssen

50–100 Holmers Farm WayHigh WycombeBuckinghamshire HP12 4EG

ViiV Healthcare UK Limited

Stockley Park WestUxbridgeMiddlesex UB11 1BT


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PublishingConferencesSecretariat www.mediscript.ltd.uk




Event Diary


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During 2011 During 2012

For further information on the above events, contact:

Mediscript Ltd1 Mountview Court · 310 Friern Barnet Lane · London N20 0LD

Tel: 020 8446 8898 · Fax: 020 8446 9194 · Email: [email protected]

Fourth Annual BHIVA Conferencefor the Management of

HIV/Hepatitis Co-infection

1300–1730Wednesday 16 November 2011

One Great George Street Conference CentreLondon

Register now at: www.bhiva.org

British HIV Association [BHIVA]Autumn Conference

includingCHIVA Parallel Sessions

17–18 November 2011Queen Elizabeth II Conference Centre

LondonRegister now at: www.bhiva.org

HIV/AIDS at 30: Back to The FutureBHIVA/Wellcome TrustMultidisciplinary Event

in support of World AIDS Day

Thursday 1 December 2011Wellcome Collection Conference Centre


6th Annual Conferenceof the

Children’s HIV Association (CHIVA)

Friday 18 May 2012Lakeside Centre

Birmingham

BHIVA/Royal College of Obstetriciansand Gynaecologists Conference

HIV and Pregnancy

20 January 2012Royal College of Obstetricians

and GynaecologistsLondon

BHIVA ‘Best of CROI’ Feedback Meetings

from week commencing 19 March 2012Cities and Venues tbc

18th Annual Conferenceof the British HIV Association

17–20 April 2012International Convention Centre

Birmingham

BHIVA Inpatient General Medicinefor HIV Physicians Course

Tuesday 6 December 2011Royal Society of Medicine


14th Annual Conferenceof the

National HIV Nurses Association

14–15 June 2012Manchester Conference Centre




http://www.bhiva.org




Resistance15th


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15th

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HIV AS A VIROLOGICAL PARADIGM

15th Annual Resistance and Antiviral Therapy Meeting

HIV AS A VIROLOGICAL PARADIGM

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resistance 15 · introduction page 3 programme page 4,5 conference information page 6,7 biographies...

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