research methodologies for assessing health effects of air ...iaapc.in/1 arunsharma-research...
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Research Methodologies for Assessing Health Effects of Air Pollution
Dr. Arun Kr Sharma, MD, MBA
Professor
Community Medicine, Biostatistics
University College of Medical Sciences
University of Delhi
Delhi, India
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Knowledge gaps
• Pollution and pollutants inventory
• Burden of disease: At regional, state and local level
• Cause-effect relationship
• Web of causation in multifactorial environment
• Disease and pollution mapping
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Health effects assessment
• Burden of diseases assessment
• Spatio-temporal distribution of disease
• Real time risk assessment
• Multifactorial causality analysis
• Hill’s criteria of causality
• Understanding etio-pathogenesis
• Intervention impact assessment
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Research methods: Burden of disease assessment
• Community based surveys: cross sectional studies
• Macro level and micro level surveys
• Spatial distribution of diseases and risks using land use pattern and activity pattern studies
• Time motion studies for temporal analysis
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Research methods: Risk assessment
• Empirical associations are weak
• Extrapolation of studies in low exposure setting to high exposure scenario are partially flawed
• Multifactorial etio-pathogenesis should be addressed through integrated exposure assessment
• Micro environment studies are to be set up
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Risk assessment studies
• Prospective cohort studies
• Case control studies
• Nested case control studies
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Research methods: Intervention impact assessment
• Experimental studies:
– Randomized control trials
– Pre-post study designs
– Cross over trials
• Quasi experimental studies
• Observational studies of human behavior: self exposed interventions
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Muttli-disciplinary, multi-stake holder approaches
• Integrated exposure assessment
• Industry interventions are not evaluated
• Newer technologies are to be tried and tested before implementation
• Pilot studies
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UGC funded project: 2012-2014
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Results
• 1999 households were surveyed covering a total population of 9509 and in industrial area
• 1900 households were surveyed covering a total population of 8128 and in residential area
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Map 1: Map of Ludhiana
showing surveyed area and
location of cases
Prevalence: 3.17/1000 pop.
Industrial 4.2/1000
Residential 1.96/1000
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Map 2: Colony wise
prevalence of COPD in
Ludhiana
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EFFECT OF AIR POLLUTION AND WEATHER
CHANGES ON EXACERBATION OF ASTHMA:
A COHORT STUDY
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Episodes per
participant
Bronchial Asthma in Delhi, India
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33.3% 37.3% 13.7% 11.8% 4%
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Season wise distribution of exacerbation episodes
Spring Summer
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Season wise distribution of exacerbation episodes
Monsoon Winter
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Episode frequency and exposure to Passive smoking at home
6/2/2019 IAPSM GC 2017 19
Incidence
5.8/100 person-fortnight
3.4/100 person-fortnight
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Episode frequency and presence of separate kitchen
6/2/2019 IAPSM GC 2017 20
Incidence
7.37/100 person-fortnight
4.05/100 person-fortnight
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Table: MLR model using all significant variables from bi-variate analysis
Risk factors Adjusted OR
95% CI P-value
Education 0.516 0.22 -1.18 0.119
No separate kitchen
2.34 0.29 - 18.30 0.417
Poor ventilation 2.69 0.35- 20.47 0.338
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Table: GEE model for association of selected air pollutants with acute episodes of Bronchial asthma
Air pollutants Coefficient S.E. Z score p
SO2 0.002 0.005 0.51 0.608
NO2 0.002 0.003 0.70 0.487
RSPM 0.006 0.002 2.16 0.031
Constant 1.151 0.530 2.17 0.030
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Clustering of exacerbations episodes
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Lung function status of females attending University
• FVC, FEV1, PEF and FEF(25-75%) was lower than the predicted mean value
• FEV1/ FVC and PEF inversely associated with the years of residence in Delhi.
• FEV1 for those using closed transport like car, metro, A/C bus were better than those using open transport like a non-A/C bus and two wheelers
• FEV1 was significantly associated with presence of polluting industries
• Significant decrease in FVC and FEV1 among active and passive tobacco smokers
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Spatial Epidemiology of Chronic Respiratory Illnesses in Urban India (STEPCRUISE) (2017-19)
Project funded by Dept. of Health Research, Govt. of India
Objectives:
• Mapping of COPD in Delhi
• Real time assessment of exposure to PM2.5
• Indoor and ambient air quality monitoring in micro environments
Methods:
• Door to door survey
• Spirometry based diagnosis
• Use of Cascade impactor based Personal Air Sampling for exposure
• Low cost sensor based indoor air quality monitoring
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Key Recommendations
• Promote research at local level to understand the local burden of diseases due to pollution in terms of disability, morbidity, mortality and productivity losses
• Participate in interdisciplinary research
• Community participation in research
• Use of appropriate low cost mitigation techniques
• Behavior change studies
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• Collect, compile, analyze and disseminate data pertaining to health effects of pollution
• Make data accessible across board
• Set up cohort studies for long term research
• Forge partnerships among stake holders: Municipal bodies, transport sector, industries, public health services and medical facilities
Key recommendations
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Thank You
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