research highlights biocatalysis and biotechnology...
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Biocatalysis and Biotechnology (BB)Investigator Department ExpertisePing Wang* BBE Enzymology and biocatalysis, bioconversion and
biosynthesis, biomaterials and functional coatings, bioelectrochemical processing, biosensors.
Mark Distefano Chem Organic and biochem., protein conjugates for therapeutic and biotechnology applications.
Mikael Elias Biochem Protein engineering and evolution, molecular modelling andrecognition, bioremediation and quorum quenching strategies.
Wei-Shou Hu CEMS Systems biotechnology, biochemical engineering, cell culture bioprocessing, stem cell technology
Romas Kazlauskas Biochem Biocatalytic synthesis of chemical intermediates and biofuels, enzyme modification for new reactions.
Lawrence Wackett Biochem Enzymes in biotechnology, immobilization technology, bioremediation, computer prediction tools for biocatalysis
Kechun Zhang CEMS Synthetic biology, metabolic engineering, protein engineering, biofuels, renewable chemicals.
*Program Leader (Email: [email protected]; Phone: 612-624-4792)
Chemical and fuel bioprocessing; Biocatalyst engineering; Biotransformation and Bioremediation; Enzyme evolution; Bio-based polymers and biocoatings; Pathway engineering; Synthetic biology; Systems biotechnology; Cell culture bioprocessing
Enzymatic Protein Labeling
Mark Distefano is exploring how proteinsaccelerate chemical reactions and howproteins recognize other molecules with highspecificity. This information is useful for drugdesign and biotechnology applications.
http://www.bti.umn.edu/faculty/biodistefano.html
Distefano Lab
Fluorescent labeling of CNTF
Protein prenylation is a ubiquitous post-translational modification
Elias LabProtein Evolution and Bioremediation
Molecular engineering
Towards a sustainable use and reuse of key resources:the case of phosphorus
Innovative and green solution against bacterial biofilms and antibiotic-resistant bacteria
Enzymatic interference in bacterialcommunication using engineered lactonases
Biofilm inhibition by lactonases
Our Lab aims to decipher the mechanisms by whichbiological macromolecules evolve, to understandthe molecular basis of their biological functions,and to develop new methods for their engineering,with the aim of developing efficient, cost-effective,ecological and sustainable solutions to existing oremerging society issues.
Molecular evolution technology combining structural analysis and
phylogeny-inferred information.
Structural and enzymatic characterization of improved variants
Virulence factors inhibition – in vivo increase of
survival in a rat pneumonia model
Anti-foulingpaints
Anti-virulencebandage
Phosphate is an environmental
pollutant
Phosphate, an essential fertilizer
for food production, is a
very finite resource
Study, and molecular
engineering of the bacterial phosphate uptake transporter
Bioconversion of wastewater into clean water and
fertilizer
http://www.eliaslab.orgMore info and contacts:
Systems Design and Cell EngineeringHu Lab
Genome engineering for biomanufacturing, genome technology for CHO cells
Stem cell engineering for hepatic applications, biomanufacturing, for cell therapy
Biofilm and antibiotic resistance transmission, microbial invasion
Chinese hamster
Chinese hamster iPSC
Enterocuccus facaelis
http://www.cems.umn.edu/people/faculty/wei-shou-hu
Kazlauskas Lab
- engineers enzymes tobe more stable, to havehigher selectivity andeven to catalyze newreactions.
http://www.umn.edu/~rjk
Reconstructed ancestral esterases and hydroxynitrile lyases are more promiscuous than modern enzymes
Protein Engineering
Ancestral catalyze new reactions
Enzymatic rapid testfor melamine in milk
Enzymatic water treatmentTo remove herbicides
Immobilizing bacteria in fibersMolecular modeling
Bioremediationproducts
Wackett labEnzymes, Immobilization technology, Bioremediation, Computer tools for biocatalysis prediction
http://www.cbs.umn.edu/research/research-cbs/faculty-labs/wackett
Enzyme Technology
Pool water treatment
Bioproducts Innovations and Pathway Engineering
Our research program combinesprinciples of chemistry, biologyand engineering to achievebiosynthesis beyond nature
http://www.cems.umn.edu/about/people/faculty.id21395.html
Zhang Lab