research and innovation an overview of the ec’s research initiatives for healthcare dr karim...

Research and Innovation

An overview of the EC’s research initiatives for healthcare

Dr Karim Berkouk,Deputy Head of Unit

DG for Research and InnovationHealth Directorate

European Commission


• Ageing population

• Increased disease burden: chronic diseases

• Health & care sector unsustainable: under pressure to reform

• Health industry under pressure for innovative solution

Health main challenges


• Early origins of lung diseases: prenatal nutritional deficiencies or maternal smoking; severe early infections; genetic and epigenetic factors related to the natural and anthropogenic environment

• Lifestyle and lung health: nutrition, active and passive smoking, physical inactivity, social inequities

• Environment: ozone and particulate matters , occupational exposure, indoor air quality and nanomaterials

• Early diagnosis, vaccines and treatments (especially for resistant pathogens) lung infections

• Ageing population: comorbidities, increased disease and economic burden

Respiratory Diseases (RD) main challenges

From the European Respiratory roadmap. Recommendations for the future of respiratory medicine. European Respiratory Society. 2011.


EU health Research

Collaborative Research

Bottom-up researchERC, MC

Public-Private

PartnershipsIMI

Bio-Eco

CapacityBuilding

Infrastructures(CT, registries,

biobank)

LegislationReg. or

Direc. (eg CT, data

protection, medical devices)

Internationalco-operation

Global consortia GACD

MS Coordination

ERA-NETJPIs (JPND), MYBL, AAL,

EIP AHAJoint Action

The EU means


FP 7 - State of PlayHealth research

Key figures

5,5 b€ invested to date

1053 projects

12 520 participations

3 615 organisations

123 countries

First outcomes (on 363 closed projects)

12 269 publications

3,1 average SJR* publication

228 patent applications

31 spin-offs created

* SCImago Journal Ranking


• basic research

• translational research COPD

Pneumonia

Asthma

Tuberculosis

Collaborative research: 236

Frontier Research: 32

SME: 9

Training & Mobility: 14

€ 290 Million on Respiratory Diseases

(in million Euro)


Large cohort studies in asthma and COPD by studying specific genetic markers and related phenotypes e.g.: longitudinal, population based studies: MeDALL, COPACETIC,

EVA, ESCAPE birth cohort studies: CHICOS

Drug development, personalised medicine & Technology Prognostic & PM: AirPROM, U-BIOPRED Technology for home care (HOMECARE) and bio-artificial lung

(Ambulung )

Respiratory infections (e.g. TB ; antimicrobial resistance)

Coordinating research in RD in Europe (EARIP)

FP7 Overview 2007-2013


€ 16.8 millionhttp://www.proactivecopd.com

Aim: to develop new tools that will enable patients, their doctors and clinical researchers to accurately assess the improvement or deterioration of COPD.

Tools tested on more than 600 COPD patients:

A user friendly electronic tool will help patients to assess on a day-to-day basis the activities in which they engage and the symptoms associated to these activities.

Another tool will be used during hospital visits to assess the patients' physical activity and experience of the disease.

Physical Activity as a Crucial Patient Reported Outcome in COPD (PROactive)


Horizon 2020

Perspectives


Threepriorities

•Excellent science

•Industrial leadership

•Societal challenges

• European Research Council• Future and Emerging Technologies• Marie Skłodowska-Curie actions• Research infrastructures

• Leadership in enabling and industrial technologies

• Access to risk finance

• Innovation in SMEs

• Health, demographic change and wellbeing

• Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the Bioeconomy

• Secure, clean and efficient energy

• Smart, green and integrated transport

• Climate action, environment, resource efficiency and raw materials

• Inclusive, innovative and reflective societies

• Secure societies• Science with and for

society• Spreading excellence

and widening participation

Budget:about €79 Billion


Advancing active and healthy ageing

Integrated, sustainable, citizen-centred care

Improving health information, data exploitation and providing an evidence base for health policies and regulation

Innovative treatments and technologies

Improving diagnosis

Effective health promotion, disease prevention,preparedness and screening

Understanding health, ageing & disease

WP 2014/2015: € 1,2 billionFunding: € 7.5 Billion

Health, Demographic change and wellbeing


• Understanding health, ageing and disease: determinants, risk factors and pathways

• Comparing the effectiveness of existing healthcare interventions in the elderly

• New therapies for chronic non-communicable diseases

• Health promotion and disease prevention: translating ‘omics’ into stratified approaches

• Evaluating existing screening and prevention programmes

• Advancing bioinformatics to meet biomedical and clinical needs

Topics 2014 relevant for RD


• Understanding common mechanisms of diseases and their relevance in co-morbidities

• Health promotion and disease prevention (environment and health based interventions)

• Development of new diagnostic tools and technologies: in vivo medical imaging technologies

• Tools and technologies for advanced therapies

• Establishing effectiveness of health care interventions in the paediatric population

• Piloting personalised medicine in health and care systems

Topics 2015 relevant for RD


Strategic Initiatives

Innovative Medicines Initiative 2 www.imi.europa.eu

European & Developing Countries Clinical Trials Partnership (EDCTP2)

www.edctp.org

Active and Assisted Living 2www.aal-europe.eu

European Innovation Partnership on Active and Healthy Ageing

https://webgate.ec.europa.eu/eipaha


International cooperation: how?

• Identify and define sharedstrategic goals

• Agree to approach jointly andshare tasks (and costs)

• Let each agency use its own funding mechanisms/timing

• Agree to share data / standards

Alignment – Flexibility – CommitmentExample: Global Alliance for Chronic Diseases (GACD)

research and innovation an overview of the ec’s research initiatives for healthcare dr karim...

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