Renal pathologyRenal pathology

Nephrotic SyndromeNephrotic Syndrome

Primary glomerular diseasesPrimary glomerular diseases

1.1. Minimal change disease / Lipoid nephrosisMinimal change disease / Lipoid nephrosis

2.2. Focal Segmental GlomerulosclerosisFocal Segmental Glomerulosclerosis

3.3. Membranous Nephropathy /MGNMembranous Nephropathy /MGN

4.4. MPGNMPGN

Minimal change disease / Lipoid Minimal change disease / Lipoid nephrosisnephrosis

Normal in light microscopyNormal in light microscopy Electron Electron diffuse effacement of podocyte diffuse effacement of podocyte

foot processesfoot processes

Membranous GlomerulonephritisMembranous Glomerulonephritis

MPGNMPGN

Nephritic SyndromeNephritic Syndrome

1.1. Acute Post infectious GNAcute Post infectious GN

2.2. IgA NephropathyIgA Nephropathy

3.3. Heriditary nephritisHeriditary nephritis

Post streptococcal GNPost streptococcal GN

Ig A NephropathyIg A Nephropathy

Usually affects children and young adultsUsually affects children and young adults 1 or 2 days after a non specific upper 1 or 2 days after a non specific upper

respiratory tract infectionrespiratory tract infection

Deposition of Ig A in the mesangium is the Deposition of Ig A in the mesangium is the hallmark of the diseasehallmark of the disease

Histo Histo

Variable Variable FPFP MPMP Crescentic GnCrescentic Gn

RPGN/ CrescenticRPGN/ Crescentic

Clinical syndromeClinical syndrome Not a specific etiological form of GNNot a specific etiological form of GN

Types Types

Type 1 Type 1 Anti GBM antibodyAnti GBM antibody Good Good Pasture SyndromePasture Syndrome

Type 2 Type 2 Immune complex Immune complex Post Post infectious , SLE , IgA nephropathyinfectious , SLE , IgA nephropathy

Type 3 Type 3 Pauci immune – ANCA Pauci immune – ANCA associated-----Wegener’s Granulomatosis , associated-----Wegener’s Granulomatosis , Microscopic angitisMicroscopic angitis

Type 1 Type 1

Type 2 Type 2

Renal Cell CarcinomaRenal Cell Carcinoma

1.1. Clear cell carcinomaClear cell carcinoma

2.2. Papillary carcinomaPapillary carcinoma

3.3. Chromophobe carcinomaChromophobe carcinoma

4.4. Collecting Duct carcinomaCollecting Duct carcinoma