remission of korean non-insulin dependent diabetes mellitus by continuous subcutaneous insulin...
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Remission of Korean Non-Insulin Remission of Korean Non-Insulin Dependent Diabetes Mellitus by Dependent Diabetes Mellitus by
Continuous Subcutaneous Insulin Continuous Subcutaneous Insulin Infusion TreatmentInfusion Treatment
Konkuk University Diabetic Center
Soobong Choi, M.D. Ph.D., Sunmin Park
Diabetes/Metabolism Research and Review, March, 2003
Remission PatternRemission Pattern
REMISSION
CSII TX.
(Months)
(Case No.)
50
70
90
110
130
150
170
190
210
230
250
0 1 2 3 4 5 6 70
10
20
30
40
50
60
0 2 4 6 8
INSULIN DOSE BLOOD GLUCOSE
(wks)
(U/day) (mg/dL)
p< 0.05 p< 0.05
(wks)
Non-Remission. Remission.
Changes of blood glucose levels and total daily
insulin dosage
0
5
10
15
20
0 6 65
0
2
4
6
8
10
12
14
0 6 65
Fasting BG Post-prandial BG
(wks)
mmol/L mmol/L
(wks)
**
### ###
**Significantly different from remission group at p<0.01.### Significantly different from the baseline at p<0.001.
### ###
Non-Remission. Remission.
Changes of Blood Glucose Changes of Blood Glucose after CSIIafter CSII
10
15
20
25
30
0 6 65
0
2
4
6
8
10
12
14
16
0 6 65
Hemoglobin A1c BMI % kg/m2
(wks)(wks)
### Significantly different from the baseline at p<0.001. # p<0.05.
######
Non-Remission. Remission.
Changes of Hemoglobin A1c Changes of Hemoglobin A1c and BMI after CSIIand BMI after CSII
0
0.5
1
1.5
2
2.5
3
3.5
4
0 6 650
0.5
1
1.5
2
2.5
3
3.5
4
0 6 65
Fasting c-peptide Post-prandial c-peptide
(wks)
nmol/L nmol/L
(wks)
*
*
*
**## ##
**Significantly different from remission group at p<0.01. * p<0.05.## Significantly different from the baseline at p<0.01.
Non-Remission. Remission.
Plasma C-Peptide after Plasma C-Peptide after CSIICSII
(yrs)
Non-Remiss. CaseRemission Case
Duration
Remission and DurationRemission and Duration