recombination early experiments: 1947 alfred hershey and max delbrück 1961 matthew meselson and...

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  • Slide 1
  • Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrck 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific Recombination *Transposition
  • Slide 2
  • Homologous Recombination *Two broad categories (pathways):
  • Slide 3
  • Homologous Recombination
  • Slide 4
  • Slide 5
  • RecBCD Pathway http://www.esrf.eu/news/spotlight/spotlight13dnarepair/spotlight_dna_repair_fig1s
  • Slide 6
  • RecBCD Pathway RecA filament
  • Slide 7
  • RecA at work
  • Slide 8
  • RuvAB facilitate branch migration
  • Slide 9
  • Slide 10
  • Gene Targeting in Embryonic Stem Cells www.nobelprize.org
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  • Gene Targeting in Embryonic Stem Cells www.nobelprize.org
  • Slide 12