recent and remote episodic, semantic, and spatial memory in

The Cognitive Neuroscience of Memory and its Relevance to Meme Research

Morris Moscovitch

Rotman Research Institute andDepartment of Psychology

Baycrest Centre for Geriatric Care University of Toronto

Memory, Social Networks, and Language: Probing the Meme Hypothesis II

May 15-17Victoria College, University of Toronto

U of T

Collaborators• Gordon Winocur – Rotman Research Inst., Trent U.• Lynn Nadel – U of Arizona• Carlo Umiltà – U of Padova• Cheryl Grady - Rotman Research Inst.• Brian Levine - Rotman Research Inst.• Morris Freedman – Rotman Research Inst.• Mary Pat McAndrews - Toronto Western• Sandra Black – Sunnybrook • Fuqiang Gao – Sunnybrook• Marilyne Ziegler- University of Toronto• Baycrest Psychologists – Baycrest Psychology

Collaborators• Robyn Westmacott – Hospital for Sick

Children• Shayna Rosenbaum – York University and

Rotman Research Inst.• Asaf Gilboa – Haifa University• Donna Addis – Harvard University• Lillian Park – Rotman Research Institute• Signy Sheldon – University of Toronto

Meme – A unit of cultural information that can be transmitted

and replicated, but also altered in the process.

Memory would seem to be crucial to meme formation and transmission.

But what kind of memory? And what kind of memory processes?

Types of Memory: HumanTypes of Memory: Human

Explicit Implicit

Episodic Perceptual Conceptual

Semantic Motor (procedural)

Dissociation between Episodic and Semantic Memory: Comparison of

Two Patients

Patient K.C.• right-handed man with bilateral hippocampal

damage from head injury that occurred in 1981, when he was 31 years old

• preserved remote semantic memory• cursory evidence of impaired autobiographical

episodic memory for all times in his life

Remote Memory in Amnesia

ACB

KC’s MTL lesions

A m n es ic P a tien t K .C . N o rm a l C o n tro l S u b jec t

MTL & Related Structures

Anterior thalamicnucleus

Mediodorsal thalamicnucleus

CingulateGyrus

Fornix

Corpus Callosum

Alveus of thehippocampus

SubiculumDentategyrus

ParahippocampalGyrus

Pes HippocampiAmygdala

PrecommissuralFornix

PostcommissuralFornix

Anteriorcommissure

Septalnuclei

Mammillarybodies

HPC-neocortical connections (from

Treves and Rolls, 1993).

Patient KC: scores on Autobiographical Memory Interview

Personalsemantics

(maximum=21)

AutobiographicalInterview

(maximum=9)

Childhood 16.0 2

Early adult life 13.5 3

Recent life 8.0 1

Semantic Dementia

Patient E.L.65 year-old man, originally from

England who worked as a graphic artist at the CBC.

Video of EL being interviewed by Morris Freedman and Morris

Moscovitch

Robyn WestmacottShayna Rosenbaum

Sandra BlackMorris Freedman

Peter GaoStefan KohlerLarry Leach

Sandra PriselacJill Rich

Shayna RosenbaumKathy Stokes

Westmacott et al., Neurocase, 2001; Cog. Neuropsychol., 2002, 2004; Neuropsychologia, 2004; Rosenbaum et al, Neuropsychologia, 2005.

K.C.'s scores on semantic and episodic variables in the photograph description task

0%

20%

40%

60%

80%

100%

Late 50's Early 60's Late 60's Early 70's Late 70's 80's 90's

Scor

e SemanticEpisodic

E.L.'s scores on recognition, naming and episodic variables in the photograph description task

0%

20%

40%

60%

80%

100%

Late 30's 40's 50's 60's 70's 80's 90's

Scor

e RecognitionEpisodicNaming

Asaf Gilboawith

Shayna Rosenbaumand Amir Poreh and Gordon Winocur

Poreh, et al, Neuropsychologia, 2006; Gilboa et al, Hippocampus, 2006.

MTL & Related Structures

Anterior thalamicnucleus

Mediodorsal thalamicnucleus

CingulateGyrus

Fornix

Corpus Callosum

Alveus of thehippocampus

SubiculumDentategyrus

ParahippocampalGyrus

Pes HippocampiAmygdala

PrecommissuralFornix

PostcommissuralFornix

Anteriorcommissure

Septalnuclei

Mammillarybodies

Fornix lesions are a crucial test of EHS hypothesis

Patients with fornix lesion

• Fornix lesions prevent major hippocampal output while leaving the hippocampus, the rest of MTL, and neocortex intact.

• According to our hypothesis that the hippocampus is necessary for recollection, autobiographical memories, whether recent or remote, should be impaired in people with fornix lesions.

The Case of D.A. p.s.

• An educated 45-year-old right-handed male. Arrived with a one-month history of excruciating headaches.

• Continued working up to the time of his surgery.

• An MRI T1 revealed a typical colloid-cyst situated in the anterior part of the IIIrd ventricle, with a mild degree of obstructive hydrocephalus.

Colloid cyst

ADFAge-matched control

ADF’s Fornix lesions

Other memory-related lesionsBasal forebrain Basal ganglia

ADF ADFControlControl

Famous Faces and Events

TASKTASK YEARSYEARS % Correct % Correct

Famous Faces 1970-80 951981-90 961991-99 99

Famous Events 1970-80 1001981-90 951991-99 90

Personal Episodes 1970-80 501981-90 501991-99 40

Reaction to Photos from Significant Personal Events

• His Photograph of an Army Camp 73 • Army base, these are T. type tanks. When was the picture taken? Why

was it taken? I don’t know.• Group photograph of a graduation ceremony in 1984 • This is the graduation ceremony of some kind of training. I can't

remember the ceremony. • Photograph of the circumcision of his son 1987 • Looks at the picture for 5min: This is a circumcision rite. I can see the

baby. He didn’t identify his son.• A picture from a trip to Greece 97• A trip to Turkey (Wife =No). Rhodes? (wife =no) …we went on a train

(wife= by a boat).

Summary of Studies of Patients with Hippocampal Complex

Lesions•Autobiographical Memory: Extensive RA, sometimes even without a temporal gradient

Summary of Studies of Patients with Hippocampal Complex

Lesions•Autobiographical Memory: Extensive RA, sometimes even without a temporal gradient•Semantic Memory:Limited RA, most often with a temporal gradient

Two Components of Episodic Memory(Tulving, 1985)

• Recollection: Re-experiencing or reliving a past event in the mind; mental time travel. Characterized by recovering and recreating the context in which a stimulus or event occurred.

• Familiarity: A stimulus is recognized or experienced as old, but little or no information is associated about the context in which it was encountered. Resembles semantic memory

Two Components of Episodic Memory(Tulving, 1985)

• Recollection: re-experiencing or reliving a past event in the mind; mental time travel. Characterized by recovering and recreating the context in which a stimulus or event occurred.

• Familiarity: A stimulus is recognized or experienced as old, but little or no information is associated about the context in which it was encountered. Resembles semantic memory.

Why should recollection be associated with the

hippocampus?

Carlo Umiltà & Gordon Winocur

A component process of memory based on modules and central systems

Moscovitch and Umiltà (1990, 1991); Moscovitch and Winocur (1992); Moscovitch (1992)

A. Encoding B. Cohesion C. Consolidation Remembering

A

A B C

HIPPOCAMPALCOMPLEX

Event

A B C

HIPPOCAMPALCOMPLEX

Event

HIPPOCAMPALCOMPLEX

HIPPOCAMPALCOMPLEX

B

HIPPOCAMPALCOMPLEX

Event

Hi Hi

B BB C A CACA B C B

HIPPOCAMPALCOMPLEX

Hi

CBA

NEO

CO

RTE

X

The hippocampus is essential for encoding, retaining, and

recovering experiences (i.e. recollection).

The hippocampal complex (or medial temporal lobe) is a ‘stupid’ module that automatically encodes all information that is apprehended consciously, and retrieves information obligatorily in response to a proper, proximal cue.

Strategic Memory Processes:The Frontal Lobe as a

Working-with-Memory Structure(Moscovitch & Winocur, 1992, 2002:Moscovitch, 1992)

A. Encoding B. Cohesion C. Consolidation Remembering

A

A B C

HIPPOCAMPALCOMPLEX

Event

A B C

HIPPOCAMPALCOMPLEX

Event

HIPPOCAMPALCOMPLEX

HIPPOCAMPALCOMPLEX

B

HIPPOCAMPALCOMPLEX

Event

Hi Hi

B BB C A CACA B C B

HIPPOCAMPALCOMPLEX

Hi

CBA

NEO

CO

RTE

XFR

ON

TAL

FRO

NTA

L

The hippocampus is essential for encoding, retaining, and recovering

experiences (i.e. recollection) which the prefrontal cortex selects, organizes, monitors, and verifies.

Retrieval from the Hippocampus is also ‘stupid’ (automatic and

unorganized), needing the prefrontal cortex to make

retrieval ‘intelligent’ (goal-directed).

Summary• Memories are not stored as whole representations

of events, but as elements of the event which need to be reconstructed into a coherent narrative. Storage is random.

• Memories are represented as beads in a jar which need the prefrontal cortex to string into a necklace.

• Narratives are better suited than single items for investigations of reconstructive memory.

Memory is reconstructive: Bartlett, Remembering (1932)

“The first notion to get rid of is that memory is primarily reduplicative, or reproductive…re-excitement of individual traces did not look to be in the least what was happening... remembering appears to be far more decisively an affair of construction than one of mere reproduction.” pp204-205.

Implications• Recollection: Detailed re-experiencing of a past

event always will depend on the hippocampus, no matter when the event occurred.

• Automaticity: A proper cue will reactivate “hippocampal” memories automatically and influence performance even on non-episodic tasks.

• Random Storage: Allows for recombination of elements needed for construction of scenarios in many domains, from reconstructing the past, imagining the future, and solving problems.

Asaf GilboaCheryl Grady

Gordon WinocurMorris Moscovitch

Gilboa et al., Cerebral Cortex, 2004.

Remote Autobiographical Memory

In normal people, the hippocampus should be much more activated for vivid memories (recollection) than for those that are not (familiarity) no matter how long ago the memory occurred.

Autobiographical memory

SELF OTHER

A. Family Photos

B. Rating scales (e.g. vividness/re-experiencing)

C. Semi-structured interviews (Levine et al., 2002)

Gilboa et al., 2004

Experiment

• Measure brain activity with fMRI (1.5 T)• Three to four time periods

– childhood– teen/ early adult– middle years– recent

• Photos matched for content as much as possible

fMRI Design

30 sec stimulus presentation (5 blocks of each type of photo per run)6 sec fixation in between each photo

Self SelfOther Other

fix fix fix

Activations in vividly vs. poorly recalled Activations in vividly vs. poorly recalled remote events: Hippocampusremote events: Hippocampus

X=-27 Y=-21 Z=-16

Hippocampal activation is mediated by extent of re-experiencing

X= -27, Y= –21, Z= –16; t=5. 75

High vividness vs. low vividness remote memories

Foci of left hippocampal activations across subjects

Remote events

Recent events

The hippocampus and remote episodic memories- comment

• Active specifically when re-experiencing

• Active for both remote and recent AM

• Different distribution of activation- may account for gradients in retrograde amnesia

Autobiographical Memory Network

Donna Addis Mary Pat McAndrews Randy McIntosh Morris Moscovitch

Hippocampus, 2007

The hippocampus is a hub linking other areas which represent different

aspects of autobiographical re-experiencing

Semantic memory• Generic: Facts and general knowledge

about the world, language, etc.

• Personal: Facts and knowledge about oneself.

For both types, there is little or no information about the context in which the knowledge was acquired. There is no experiential component.

Semantic Memory

The hippocampus slowly “nurtures” the development of neocortical (NC) traces that reflect the statistical properties of the world and/or of memories - the gist is extracted

Names of famous People1940s: Joseph Cotten; Johnny Longden

1950s: Althea Gibson; Buddy Holly

1960s: Janet Leigh; Barbara Billinglsly

1970s: Loretta Switt; Phil Esposito

1980s: Gary Coleman; Ben Johnson

1990s: Tonya Harding; Monica Lewinsky

K.C.'s performance on the name categorization task

0%

20%

40%

60%

80%

100%

Time Period

Per

cent

age

Cor

rect

Control K.C. GuessK.C. Explicit

Words Entering the Language1940s: Gasser; Hep-cat

1950s: Honcho; Univac

1960s: Hippie; Psychedelic

1970s: Velcro; Disco

1980s: Microwave; Nuke

1990s: Homophobia; Viagra

The hippocampus contributes, but is not necessary, for the retention and

recovery of semantic memory and of items which are merely familiar.

What accounts for both temporal gradients?

• For the first 5-10 years, memories retain their experiential qualities which contribute to recovery of semantic memory.

Multiple Trace Theory(Nadel & Moscovitch, Current Opinion in Neurobiology,

1997; Moscovitch et al, Journal of Anatomy, 2005)

Episodic

SemanticLoves

Swims

BBQs

Cycles

HIPPOCAMPAL COMPLEX

NEOCORTICAL MODULES

Episodic

SemanticLoves

Swims

BBQs

Cycles

Cue:

“KNOW”

HIPPOCAMPAL COMPLEX

NEOCORTICAL MODULES

Episodic

Multiple Trace Formation

SemanticBBQs

Paints

Loves

Golfs

NEOCORTICAL MODULES

HIPPOCAMPAL COMPLEX

Episodic


SemanticBBQs

Paints

Loves

Golfs

HIPPOCAMPAL COMPLEX

NEOCORTICAL MODULES

Episodic


SemanticLoves

Golfs

BBQs

Paints

HIPPOCAMPAL COMPLEX

NEOCORTICAL MODULES

Episodic

SemanticBBQs

Paints

Loves

Golfs

Cue:

“REMEMBER”

HIPPOCAMPAL COMPLEX

NEOCORTICAL MODULES

Episodic


Semantic

Loves

Golfs

BBQs

Paints

HIPPOCAMPAL COMPLEX

NEOCORTICAL MODULES

Loves

Swims

BBQs

Cycles

Robyn WestmacottLillian Park

Signy SheldonMary Pat McAndrews

Remember/Know (Re-experiencing/Familiarity)

Judgementsof Famous People

Westmacott & Moscovitch, Memory & Cognition, 2003; Westmacott et al, Neuropsychologia, 2004.

ProcedureNorms were derived by having participants rate about 300 names of famous people on familiarity, facts known about them, emotionality, and personal significance.

50 famous names were selected, half of which were associated with high R responses and half with low R (K) responses in the general population. The R and K items were matched for familiarity and facts known about them.

Procedure

Participants Reaction times to read the names and make fame judgments about them were recorded.

After the tasks were completed, each

subject rated the names on the extent to which they evoked a personal memory.

Remember vs. Know Left anterior hippocampal activation

Know vs. Non-famous

No MTL activation

Peak Hippocampal Activation

-0.20-0.15-0.10-0.050.000.050.100.150.20

1

Remember Know

% S

igna

l Cha

nge

Conclusion

Recollection influences semantic judgment and reading times.

The influence of recollection on semantics is mediated by the hippocampus.

Conclusions

1. The Hippocampus is needed for storage and retrieval of rich, autobiographical memories as long as they exist. Such memories are NOT transferred to neocortex. The hippocampus plays the same role for remote memories as it does for recent memories.

Conclusions

2. The HP Complex contributes to the Neocortical strengthening and development of semantic memories of words, concepts, events, people and space - and even the gist of autobiographical memories.

Conclusions

3.Semantic memories may retain an autobiographical component which remains HP dependent.

Recollection in the Service of Problem Solving

Signy SheldonAida Ramos

Morris Moscovitch

Why do we need this detailed autobiographical memory?

• Planning for the future • Imagination• Problem solving

Episodic Memory• Captures co-occurring, often unrelated

elements of a consciously experienced event in a single memory trace. Therefore, the memory trace is informationally rich. Ideal for cross-domain pattern matching and completion.

• Extended episodes are not stored as single representations, but as separate units and need to be reconstructed into a coherent narrative. Underlies flexibility.

Current Study

• Episodic memory may be important when solving problems that are low frequency and not well-defined.

• Such problems are frequent in social settings.

The Role of EM in Social Problem Solving

• Do episodic memories contribute to social problem solving?

• Specifically, does impaired episodic memory lead to impaired ability to solve problems in which the solutions must be re-constructed from past personal experience?

Means-End Problem Solving (MEPS; Spivak & Platt, 1975)

• Measure of real-life problem solving, typically used in clinical setting.

• Requires one to orient self and conceptualize means of moving towards a goal.

• Consists of 10 vignettes that are of a personal nature; each describes an initial problem followed by an end state. The participant is to fill in the steps taken to get from the starting position to the end state/goal.

MEPS example

H. loved her boyfriend very much, but they had many arguments. One day he left her. H. wanted things to be better. The story ends with everything being fine between

her and her boyfriend. You begin the story when H.’s boyfriend left.

Analysis: Means

- Score the number of means taken to get to the end state.

- Three types of means:- Relevant a step or action that gets the

individual closer to achieving his/her goal- Irrelevant a step or action that may be

directed toward a specific goal but that is not effective within the context of the story

- No means doesn’t provide steps to achieve a goal. e.g. a miracle solution

Example

You begin the story when H.’s boyfriend left…. The story ends with everything fine between her and her boyfriend

• Relevant: talked things over• Irrelevant: realizes cannot make it work,

so H gives up• No Mean: Waited a little while and then

everything was fine

• Score = total number of relevant means• Total Means = Relevant + Irrelevant + No

Means• Relevancy Ratio: total number relevant

means/ (relevant + irrelevant + no means)• Effectiveness Ratings: 07

MEPS and Episodic Memory• Significant correlations between the number of

specific memories generated on an autobiographical memory test and – (a) the means MEPS scores – (b) the effectiveness MEPS scores

(Beaman, et al., 2006; Goddard, et al., 1996)

• Groups with dampened specific memory recall also have lower MEPS scores– Depressed, schizophrenia

Current Study: Participants

• 12 Younger adults: mean age = 23.0• 12 Older adults: mean age = 76.8• So far, 4 Patients with medial temporal lobe

lesions

Method

• Full MEPS protocol: 10 stories• **After completed, asked:

– Have you experienced an event like this?– Vividness of recall– What information did you use to complete the

story?

Results: Means

*

0

5

10

15

20

25

30

35

40

Revelant Means Total Means

Younger

Older

*

Analysis: Details• To account for the richness of detail, we adapted the

Autobiographical Interview of Levine et al (2002).• segmented into distinct details (i.e., chunks of information)• Internal Details:

– Reflects episodic autobiographical memory– “H then went to her friends house, down the street, to talk

about her problem”• External Details:

– including semantic details, extended events and repetitions– “H always hates it when she fights with her boyfriend”

Results: Number of DetailsOlder vs Younger

0

20

40

60

80

100

120

140

160

180

Internal Details External Details

Older

Younger

*

Proportion of internal details/total details: Older vs Younger

0.5

0.55

0.6

0.65

0.7

0.75

0.8

0.85

0.9

Younger Older

*

Correlation of Internal Details to Relevant Means

40.0035.0030.0025.0020.0015.0010.00

relevant means

200.00

150.00

100.00

inte

rnal

det

ails

r=.690**

Correlation of External Details to Relevant Means

40.0035.0030.0025.0020.0015.0010.00

Relevant Means

120.00

100.00

80.00

60.00

40.00

20.00

0.00

Exte

rnal

det

ails

r=-.109 (ns)

Correlation of Internal Details to Relevant Means: Older Adults

30.0025.0020.0015.0010.00

Relevant Means

150.00

125.00

100.00

75.00

Inte

rnal

Det

ails

r=0.65**

Correlation of Internal Details to Relevant Means: Older Adults

30.0025.0020.0015.0010.00

Relevant Means

100.00

80.00

Inte

rnal

Det

ails

r=0.713**

Correlation of External Details to Relevant Means: Older Adults

30.0025.0020.0015.0010.00

Relevant Means

120.00

100.00

80.00

60.00

40.00

20.00

0.00

Exte

rnal

Det

ails

r=0.38 (ns)

Conclusions…Thus Far

• Older adults produce the same overall number of means as younger adults, BUT they produce fewer relevant means.

• Older adults produce fewer internal (episodic) details when describing solutions to social problems.

• Number of internal details is correlated with relevant means, especially in older adults

• Number of internal details in autobiographical memory is also correlated with relevant means

Broad Conclusions

• Recollection is implicated in problem solving and possibly in expertise.

• A re-evaluation of the function of the hippocampus and, by extension, what constitutes memory.

What about the creative imagination?

Memory is reconstructive: Bartlett, Remembering (1932)

“The first notion to get rid of is that memory is primarily reduplicative, or reproductive…re-excitement of individual traces did not look to be in the least what was happening... remembering appears to be far more decisively an affair of construction than one of mere reproduction.” pp204-205.

“Don’t make love to a novelist because you’ll find a description of

your body in the next book”

From an interview with a French-Canadian novelist on CBC.

Thank you

U of T

recent and remote episodic, semantic, and spatial memory in

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