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Microsystem Devices for Healthcare Applications2011 & 2018 market in M$EXECUTIVE SUMMARY
0
1000
2000
3000
4000
5000
6000
7000
2011 2012 2013 2014 2015 2016 2017 2018
BioMEMS and Microsystems for Life Science Market in $MRF ID
Strain sensors
Energy Harvesting
IR-Temperature sensors for medical Diagnostics
Flow meter for medical and Diagnostics
Microneedles
Micropumps
Inhalers
Industrial and environmental
Analytical devices
Pharmaceutical and life science research
Point of Care diagnostics
Clinical & veterinary diagnostics
X-Ray imaging
Camera pills
Endoscopes
HMDs
Microspectrometers
Human motion analysis
Accelerometer for pacemaker
Hearing Aids
Kidney Dialysis
Respiratory equipment
Ventilator & Anesthesia
Blood monitoring equipment
Blood monitoring disposable
CAGR2013-2018=24%
Microsystem Devices for Healthcare Applications2011 & 2018 market in M$EXECUTIVE SUMMARY
0
1000
2000
3000
4000
5000
6000
7000
2011 2012 2013 2014 2015 2016 2017 2018
BioMEMS and Microsystems for Life Science Market in $MRF ID
Strain sensors
Energy Harvesting
IR-Temperature sensors for medical Diagnostics
Flow meter for medical and Diagnostics
Microneedles
Micropumps
Inhalers
Industrial and environmental
Analytical devices
Pharmaceutical and life science research
Point of Care diagnostics
Clinical & veterinary diagnostics
X-Ray imaging
Camera pills
Endoscopes
HMDs
Microspectrometers
Human motion analysis
Accelerometer for pacemaker
Hearing Aids
Kidney Dialysis
Respiratory equipment
Ventilator & Anesthesia
Blood monitoring equipment
Blood monitoring disposable
CAGR2013-2018=24%
POC Positioning in the IVD Market
0
20
40
60
80
100
120
140
160
180
200
2013 2014 2015 2016 2017 2018 2019
Point of Care Contribution in the global IVD Market
clinical & veterinary diagnosticsPoint of Care diagnosticsPharmaceutical and life science research
This graph shows the market of In-Vitro Diagnostics (CAGR2014-2019=14%). The dark green bars show the evolution of the POC market (CAGR2014-2019=19%).
POC requirements – Outside of the lab testing
Reduce cost of analysis
Rapid testing
Protocols steps integration
POC Testing Based on Microfluidic
Dream or reality?
Product Company Results
i-STAT Abbott Point of Care
35 million tests in 2011More than 50,000 i-STAT handhelds are used worldwide
Piccolo® xpress Abaxis 7.5 million units of reagent discs sold in 20131072 systems have been sold during the same year.
PIMA CD4 Alere 2,000 systems installed and 2 million chips have been sold in 2011
GeneXpert Cepheid Turnover: $401M in 201319% of the turnover is linked to systems sales81% of the turnover is linked to reagent and disposable sales
Triage Alere 2 million tests per year for drug abuse testing Drug abuse test = $47 per testSystem price: $3,500
i-STAT Piccolo® xpress PIMA CD4 TriageCepheid
Top 10 Point of Care Players in 2013
19%
11%
7%
7%
7%2%4%7%
2%1%
33%
Top 10 Point of Care Players Market Shares in 2013
Johnson & Johnson
Roche Diagnostics
Abbott Molecular & Point of care
BD and company
Alere
Danaher
Cepheid
Thermo Fisher Scientific
Abaxis
Biomerieux
Others Players
2013 POC Market: $10.7B
New products are coming on the market
Lumora
Micronics
20152014
Biocartis
2012
Medimate
M bio Diagnostic
Iquum
Great basin
Time
Alere
BD
Daktari
2016
Just released on the market
New products are coming on the market
Lumora
Micronics
20152014
Biocartis
2012
Medimate
M bio Diagnostic
Iquum
Great basin
Time
Alere
BD
Daktari
2016
Just released on the market
Founded in 2007
EPFL spin off
Raised 64.5M€
Microfluidic Device standardization?
Microfluidic chip
The design of microfluidic chip is highly depending on the application! We will not see a standardization in the design itself.
Market structuration
Nevertheless, some standards couldappear for:
- Materials
- Interface between chips and externalworld
- Reagents storage
- Reagents deposition
- System for fluid management on chip(pumps, valves…)
Participants in Microfluidic consortium
Requirements and trends
CurrentMedicine
Increase Prevention through early diagnostic
Monitor drugs effects
Adapt the treatment and posology individually
PersonalizedMedicine
Microfluidic POC testing is an enabling
technology (cheap, fast, accurate) to do
this among others diagnostics methods
Microsystem Devices for Healthcare Applications2011 & 2018 market in M$EXECUTIVE SUMMARY
0
1000
2000
3000
4000
5000
6000
7000
2011 2012 2013 2014 2015 2016 2017 2018
BioMEMS and Microsystems for Life Science Market in $MRF ID
Strain sensors
Energy Harvesting
IR-Temperature sensors for medical Diagnostics
Flow meter for medical and Diagnostics
Microneedles
Micropumps
Inhalers
Industrial and environmental
Analytical devices
Pharmaceutical and life science research
Point of Care diagnostics
Clinical & veterinary diagnostics
X-Ray imaging
Camera pills
Endoscopes
HMDs
Microspectrometers
Human motion analysis
Accelerometer for pacemaker
Hearing Aids
Kidney Dialysis
Respiratory equipment
Ventilator & Anesthesia
Blood monitoring equipment
Blood monitoring disposable
CAGR2013-2018=24%
44%
33%
28%
20%18%
13%11%
9%
4%2%
0%
5%
10%
15%
20%
25%
30%
35%
40%
45%
50%
1
CAGR2013-2018
Silicon Microphones Emerging MEMS Microfluidic chips
Flow meter Microdispensers Gyroscopes
Temperature sensors Optical MEMS and image sensors Pressure sensors
Accelerometers
CAGR2013-2018 by DeviceEXECUTIVE SUMMARY
$0 .5M->$3.1 M
$1.5 B->$5.2B
$58 M->$141M
$352 M->$802M
$13 M->$24M
$39 M->$66M
$81 M->$127 M$153 M->$189 M $46.9 M->$52.3M
Examples of Players by Device Technology (not exhaustive list)
Device Manufacturers Systems Manufacturers
Pressure sensors
Silicon Microphones
Accelerometers
Examples of Players by Device Technology (not exhaustive list)
Device Manufacturers Systems Manufacturers
Micro dispensers for
drug delivery
EmergingMEMS
Infrared temperature
sensors
Only at research level
today
Agri-Agro Food Production Chain
19
Emerging applications > Agri-Agro food market
In-field testing
Input
testing
Process
testing
Final product testing
Consumer
market
Tests
Production Chain
for Agri-Agro
Food productsTests
Tests
Tests
20
In-field testing Input testing Process testingFinal product
testing
User segments
Phytosanitary and seed
companies
Farmers
Agro-cooperatives
Food
manufacturers
Traders
Food manufacturers Food manufacturers
Food marketers
Retailers
Motivations
Prove raw material quality Control purchased
ingredients
Optimize the
quality/cost ratio
Economical drivers
Comply with safety
regulations
New technologies
demandMedium Strong Strong Medium
Desired solution
On-site testing
Portative solution
Low-cost
On-site testing
Portative solution
Low-cost
On-line testing
Automatized
Sampling
(statistically
representative) and
laboratory testing
Tests realized by industrial company
Emerging applications > Agri-Agro food market
Testing Requirements Depend on the Step (1/2)
COWIN
How to generate value from European research projects results?
COWIN approach: no wonder … make things happen
Engaging ourselves in the play ground to generate value for
European collaborative research projects
COWIN
COWIN process generated value for FP6 and FP7 technology exploitation:
- 5M€ direct investment from industrials and private investors;
- 19M€ supported innovation projects with an exploitation focus with 6,9M€ investment by industry.
- 14,7M€ investment in companies exploiting FP6 and FP7 research projects results were under discussion in March (5M€ reached by October 2014)
Pilars for exploitation
Concept
R&D to Create value Exploitating to Capture value
Copyright Paul Millier – EM Lyon – Yole Finance
IP
Demonstration kits
Production
Pilars for exploitation
Concept
R&D to Create value Exploitating to Capture value
Copyright Paul Millier – EM Lyon – Yole Finance
IP
Demonstration kits
Production
The 1st customer
The « Champion »
1 200 potential users and integrators of
smart solution
• Microelectronic
players
• Private Investors
About 60 supporting COWIN
• Research results
A fertile ecosystem for growth
Panel session
o Jean-Charles Garcia – CEO Picometrics
o Jörg Nesler – CEO bi-flow
o Theo Meerts - Senior Director External Innovations DSJanssen Research & Development, J&J
o Sebastien Cargou – Elvesys
o Eric Smith – CEO Biovolt
o Julie Guigal – Go Beyond
Yole Finance new activity under launch
Technologies and
Know-HowSystems
manufacturers
Mark
ets
Yole new activity:
Value generation for RTOs and start-up companies
Access to customers
Strategic positionning
Access to private funding
Contact
Géraldine Andrieux Gustin
Yole Finance Senior Partner
+ 33 6 75 800 829
www.yole.fr
www.yolefinance.com
www.i-micronews.com