raw material catalogue for tumor markers
TRANSCRIPT
Fapon Biotech Inc.
A GLOBAL LEADING IVD REAGENT RAW MATERIALS AND ONE-STOP SOLUTIONS PROVIDER
Raw Material Catalogue for Tumor Markers
What are Tumor Markers? Tumor Markers Overview
Pro-GRP
CYFRA211
CA242
CA724
CA153
SCCA
PGI/II
CA125
CA199
HE4
CA50
AFP
CEA
PSA
02
03
05
07
09
11
13
15
20
22
24
27
29
31
34
Table of Contents02
01 Fapon Biotech Inc.
What are Tumor Markers?A tumor marker (TM) is a substance secreted or discharged by cancer cells
into body fluids or tissues, or a substance that is produced by a host in
response to the presence of new organisms in the body that has entered
body fluids or tissues. For clinical application, TMs refer to the relevant
detectable substances in serum or other body fluids. Some TMs are absent
from the normal human body, but present in embryos. Others are present
at elevated levels in cancer patients as compared with those in the normal
human body. Determination of the presence or level of TMs can aid the
diagnosis of tumors and the analysis of the course of disease, provide guidance
for treatment, and monitor recurrence or metastasis, as well as the
determination of prognosis.
Tumor Markers Overview
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02Fapon Biotech Inc.
Disease
Lung Cancer
Gastric Cancer
Colorectal Cancer
Pancreatic Cancer
Liver Cancer
Gynecologic Cancer(Ovarian & Cervical)
Testicular Cancer
Prostate Cancer
Breast Cancer
Tumor Markers
CEA, CYFRA211 (NSCLC), Pro-GRP (SCLC)
CA724, PGI/II
CEA, CA199, CA50
CEA, CA199, CA242, CA50
AFP
SCCA, CA125, HE4
AFP
PSA
CA153
Pro-GRP is highly sensitive and specific to small cell lung cancer (SCLC). As
Pro-GRP is produced in very small (or zero) quantities in the presence of
benign lesions and other cancers (including non-SCLCs), thus Pro-GRP
detection is useful to apply in diagnosis and differential diagnosis.
When Pro-GRP immunoassay is applied to SCLC diagnosis, the patient's
renal function must be examined to rule out elevated serum levels of
Pro-GRP due to reduced glomerular filtration rates. Using in combination of
renal dysfunction serum creatinine> 141 μmol/L, patient's Pro-GRP levels
will be elevated.
Pro-GRP
Recommended Pairing
Pro-GRP AntibodyAntibody
UsageSubtypeBuffer
Storage ConditionShelf Life
Purity
BENGRPS101 BENGRPS102 BENGRPS103 BENGRPS104 BENGRPS105 BENGRPS106
Coating Coating Coating Coating Labeling Coating
IgG1 IgG1 IgG1 IgG1 IgG2a IgG110mM PB + 150mM NaCl + 0.1%Proclin300, pH7.4
-20℃±5℃
≥90%
3 years
Catalog No.
BENGRPS104
BENGRPS105
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
03 Fapon Biotech Inc.
Clinical Correlation
Pairing Antigen
CLIA Linearity
Summary: Fapon's Pro-GRP exhibits excellent linearity, with a linear range of 3-5000 pg/mL and R up to 0.999.
Summary: There is an excellent clinical correlation between Fapon's Pro-GRP and the values of international top brand.
-500000
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
4000000
4500000
0 1000 2000 3000 4000 5000 6000
Val
ue
Antigen Concentration (pg/ml)
Pro-GRP CLIA Linearity
Pro-GRP Clinical Correlation
Reagent Value of International Top Brand (pg/ml)
FAPO
N's
Val
ue (p
g/m
l)
04Fapon Biotech Inc.
18 kDa25mM Tris-HCL, 0.1% SDS, pH8.0
For immune molecules or standards3 years
E.coliCatalog No.
HostMolecular Weight
Bu�er SolutionUsage
Shelf Life
2
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y = 0.849x + 38.41R² = 0.966
y = 799.1x - 12184R² = 0.999
GENGRPN101
CY211 Antibody
Recommended Pairing
With a sensitivity of 80%, CYFRA211 is utilized in the diagnosis of lung
cancer, especially non-small cell lung cancer (NSCLC). CYFRA211 can be
used for early diagnosis and is associated with tumor growth, patient
survival rates, lymph node involvement, cancer staging, etc. Therefore, it
can be used for disease progression detection and post-operative
follow-ups. Serum CYFRA211 levels in lung cancer patients who have
undergone chemotherapy are associated with treatment efficacy.
Reduced CYFRA211 levels indicate better efficacy and stable conditions,
whereas elevated levels indicate disease progression.
CYFRA211
05 Fapon Biotech Inc.
BEJCYFS101
Labeling
IgG2b
BEJCYFS102
Labeling
IgG2b
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BENCYFN105
Coating
IgG2a
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
Catalog No.
BENCYFN105
BEJCYFS101
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
Clinical Correlation
CLIA Linearity
Pairing Antigen
Summary: There is a good linear correlation between Fapon's CY211 and the reagent values of international top brand.
Summary: Fapon's CY211 exhibits excellent linearity, with a linear range of 0.1-500 ng/ml and R² of 0.999.
06Fapon Biotech Inc.
A GLOBAL LEADING IVD REAGENT RAW MATERIALS AND ONE-STOP SOLUTIONS PROVIDER
For immunoassays or calibrators20mM PB + protective protein, pH7.4
20.3 kDa5.6
-20℃ ± 5℃3 years
E.coliCatalog No.
HostUsageBu�er
Molecular WeightIsoelectric Point
Storage TemperatureShelf Life
0
100000
200000
300000
400000
500000
600000
700000
800000
900000
0 100 200 300 400 500 600
CY211 CLIA Lnearity
Antigen Concentration (ng/ml)
Val
ue
0 20 40 60 80 100 120 140 160-20
0
20
40
60
80
100
120
140
y = 0.8737x - 5.5226R² = 0.986
CY211 Clinical Correlation
Reagent Value of International Top Brand (ng/ml)
FAPO
N's
Val
ue
(ng/
ml)
y = 1521.8x + 667.51R² = 0.999
GENCAY211N101
It is a thorny issue to detect pancreatic cancer , benign liver and gallbladder
diseases using tumor markers. Receiver operating characteristic (ROC)
curve analysis of tumor markers in pancreatic cancer shows that CA242 has
a sensitivity of 70%-80% when the false positive rate in detection falls
within 10% (the specificity exceeds 90%). It serves as an independent in
dicator that helps clinicians differentiate benign and malignant conditions.
CA242
Recommended Pairing
CA242 Antibody
07 Fapon Biotech Inc.
BECCA242S103
Coating
IgM
BENCA242S101
Coating/Labeling
IgG1
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BECCA242S102
Coating/Labeling
IgG1
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
Catalog No.
BECCA242S103
BECCA242S102
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
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08Fapon Biotech Inc.
Clinical Correlation
CLIA Linearity
Pairing Antigen
Summary: There is an excellent clinical correlation between Fapon's CA242 and the values of international top brand.
Summary: Fapon's CA242 exhibits excellent linearity, with a linear range of 0.1-500 U/ml and R² of 0.998.
0
20
40
60
80
100
120
0 20 40 60 80 100 120 140 160
CA242 Clinical Correlation
Reagent Value of International Top Brand (U/ml)
FAPO
N's
Val
ue (
U/m
l)
-100000
0
100000
200000
300000
400000
500000
600000
700000
800000
0 200 400 600 800 1000 1200 1400 1600
CA242 CLIA Lnearity
Antigen Concentration (U/ml)
Val
ue
GENCA242N101Native
For immunoassays or calibrators0.9% NaCl + protective protein
-20℃ ± 5℃3 years
Catalog No.Host
UsageBu�er
Storage TemperatureShelf Life
y = 0.6543x + 3.3098R² = 0.949
y = 496.04x - 3461.3R² = 0.998
CA724 Antibody
Recommended Pairing
The positive rate of serum CA724 in patients with gastric cancer is 59%.
The positive rate of combined detection (together with CA199 and CEA) is
greater than 70%. Serum CA724 demonstrates a high specificity for the
diagnosis of malignant lesions, and is rarely detected in normal cells and
benign lesions.
In addition, CA724 exhibits a certain positive detection rate in patients
with colorectal cancer, breast cancer, cholangiocarcinoma, lung cancer
and ovarian cancer. Its positive rate in patients with concomitant distant
metastasis is even higher.
CA724
Catalog No.
BECCA724S107
BEJCA724S105
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
BECCA724S107
Coating
IgG1
BEJCA724S105
Labeling
IgG1
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BECCA724S106
Labeling
IgG1
BECCA724S105
Coating
IgG1
09 Fapon Biotech Inc.
CLIA Linearity
Pairing Antigen
Clinical Correlation
0
100000
200000
300000
400000
500000
600000
0 10050 200 300250150 350
CA724 CLIA Linearity
Val
ue
Antigen Concentration (U/ml)
Summary: There is an excellent linear correlation between Fapon's CA724 and the reagent values of international top brand.
Summary: Fapon's CA742 exhibits excellent linearity, with a linear range of 1.2-300 U/ml and R² of 0.999.
0
20
40
60
80
100
120
140
0 50 100 150 200 250 300 350
CA724 Clinical Correlation
Reagent Value of International Top Brand (U/ml)
FAPO
N's
Val
ue (
u/m
l)
GENCA724N101Native
For immunoassays or calibrators0.9% NaCl + protective protein
-20℃ ± 5℃3 years
Catalog No.Host
UsageBu�er
Storage TemperatureShelf Life
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10Fapon Biotech Inc.
y = 0.3972x + 1.7056R² = 0.957
y = 1768.9x + 166.36R² =0.999
CA153 is mainly present in several types of adenocarcinomas, such as
breast cancer, lung adenocarcinoma, ovarian cancer and pancreatic
cancer. With a low sensitivity, serum CA153 levels rarely exceed 30 kU/L in
early breast cancer, but with progressive breast cancer, 60%~80% cases
have CA153 levels above 30 kU/L. CA153 is highly associated with breast
cancer and can be used to determine breast cancer progression and
metastasis, as well as monitor treatment efficacy and recurrence. Serum
CA153 levels decrease after the effective treatment of breast cancer, and
increase in the event of metastasis or recurrence.
CA153
CA153 Antibody
Recommended Pairing
11 Fapon Biotech Inc.
Catalog No.
BECCA153S103
BEJCA153S105
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
BECCA153S102
Coating
IgG1
BEJCA153S102
Labeling
IgG1
BECCA153S103
Coating
IgG1
BEJCA153S104
Labeling
IgG1
BEJCA153S105
Labeling
IgG1
AntibodyUsage
SubtypeBuffer
Storage ConditionShelf Life
Purity
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
Clinical Correlation
Pairing Antigen
CLIA Linearity
Summary: There is a good correlation between Fapon's CA153 and the reagent values of international top brand.
Summary: Fapon's CA153 exhibits excellent linearity, with a linear range of 0.4-200 U/ml and R of 0.998.
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12Fapon Biotech Inc.
GENCA153N101Native
For immunoassays or calibrators0.9% NaCl + protective protein
-20℃ ± 5℃3 years
Catalog No.Host
UsageBu�er
Storage TemperatureShelf Life
CA153 Clinical Correlation
Reagent Value of International Top Brand (U/ml)
FAPO
N's
Val
ue (U
/ml)
0
500000
1000000
1500000
2000000
2500000
0.0 50.0 100.0 150.0 200.0 250.0
CA153 CLIA Linearity
Antigen Concentration (U/ml)
Val
ue
2
y = 0.8109x + 20.865R2 = 0.879
y = 10158x + 31842R² = 0.998
13 Fapon Biotech Inc.
SCCA Antibody
Recommended Pairing
The squamous cell carcinoma antigen (SCCA) is a tumor marker associated
with various organs. Increased SCCA can be seen in many types of
cancers, including cervical, ovarian, lung (non-small cell lung cancer), skin,
head and neck, gastrointestinal and urinary tract. Because SCCA level
rarely increases at the early stage cancer, thus it is uncommon to use
SCCA for cancer screening. The SCCA elevation is closely related to tumor
malignancy, often indicates cancer deterioration that accompanied by
metastasis, therefore SCCA is used for treatment monitoring and prognostic
evaluation. And specifically, SCCA elevation is detected in 70% advanced
cervical cancers and 90% recurrent cervical cancers.
SCCA
BEJSCCAS101
Labeling
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BECSCCAS101
CoatingIgG1
10mM PB + 150mM NaCl + 0.1%Proclin300,pH7.4
-20℃ ± 5℃
3 years
≥ 90%
Catalog No.
BECSCCAS101
BEJSCCAS101
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
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14Fapon Biotech Inc.
Clinical Correlation
CLIA Linearity
Summary: There is a good correlation between Fapon's SCCA and the reagent values of international top brand.
Summary: Fapon's SCCA exhibits excellent linearity, with a linear range of 0.4-500 ng/ml and R² of 0.999.
0
2
4
6
8
10
12
14
0 5 10 15 20 25 30 35
SCCA Clinical Correlation
Reagent Value of International Top Brand (ng/ml)
FAPO
N's
Val
ue (
ng/m
l)
-1000000
0
1000000
2000000
3000000
4000000
5000000
6000000
0 100 200 300 400 500 600
SCCA CLIA Linearity
Antigen Concentration (ng/ml)
Val
ue
y = 11133x - 35780R² = 0.999
y = 0.2801x + 3.3758R2 = 0.968
PGI Antibody
Recommended Pairing
PGI/IIPepsinogen (PG) is a precursor of pepsin that reflects the number of chief
cells. PG is classified into two types, knowing as PGI and PGII. Gastric
mucosal lesions affect PG-secreting cells and result in the change of PG
levels in serum. PGI levels elevate when gastric acid secretion increases
and reduce when gastric acid secretion decreases or gastric corpus
atrophy progresses. Therefore, PGI serves as an indicator for the detection
of gastrin cell functions.
PGII levels are associated with gastric mucosal lesions. Elevated PGII levels
may indicate fundic gland atrophy, glandular epithelium metaplasia and
dysplasia. PGI secretion and PGI/PGII levels decrease in patients with
intestinal metaplasia, atypical hyperplasia and gastric cancer. Therefore,
serum PGI/PGII levels are effective markers for the early diagnosis of
gastric cancer.
15 Fapon Biotech Inc.
Catalog No.
BECPGIS101
BEJPGIS101
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
BEJPGIS101
Labeling
IgG1
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BECPGIS101
Coating
IgG1
10mM PB + 150mM NaCl + 0.1% Proclin300, pH6.0
-20℃ ± 5℃
3 years
≥ 90%
y = 1.0027x - 3.6671R² = 0.966
-50
0
50
100
150
200
0 20 40 60 80 100 120 140 160
FAPO
N's
Val
ue (n
g/m
l)
Raw Material Value of International Top Brand (ng/ml)
PGI Clinical Correlation
Clinical Correlation
0
20
40
60
80
100
120
140
160
180
0 50 100 150 200 250
FAPO
N's
Val
ue (n
g/m
l)
PGI Clinical Correlation
Reagent Value of International Top Brand (ng/ml)
Summary: There is an excellent correlation between Fapon's PGI and the raw material values of international top brand.
Summary: There is an excellent correlation between Fapon's pairing values and the reagent values of international top brand.
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16Fapon Biotech Inc.
y = 0.7763x + 4.7998R² = 0.963
CLIA Linearity
-500000
0
500000
1000000
1500000
2000000
2500000
0 50 100 150 200 250
Val
ue
Antigen Concentration (ng/ml)
PGI CLIA Linearity
Summary: Fapon's PGI exhibits excellent linearity, with a linear range of 1-200 ng/ml and R² of 0.998.
17 Fapon Biotech Inc.
y = 11752x - 21827R² = 0.998
Clinical Correlation
PGII Antibody
Recommended Pairing
0
10
20
30
40
50
60
70
0 10 20 30 40 50 60 70
FAPO
N's
Val
ue (n
g/m
l)
Raw Material Value of International Top Brand (ng/ml)
PGII Clinical Correlation
Summary: There is an excellent correlation between Fapon's pairing values and the raw material values of international top brand.
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18Fapon Biotech Inc.
Catalog No.
BECPGIIS102
BEJPGIIS102
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
y = 1.0102x + 0.6362R² = 0.995
BECPGIIS101
Coating
IgG1
10mM PB + 150mM NaCl + 0.1%Proclin300,pH7.4
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BECPGIIS102
Coating
IgG1
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
BEJPGIIS102
Labeling
IgG1
10mM PB + 150mM NaCl + 0.1% Proclin300, pH6.0
-100000
0
100000
200000
300000
400000
500000
600000
0 20 40 60 80 100 120
Val
ue
Antigen Concentration (ng/ml)
PGII CLIA Linearity
0
10
20
30
40
50
60
70
0 10 20 30 40 50 60
PGII Clinical Correlation
FAPO
N's
Val
ue (n
g/m
L)
Reagent Value of International Top Brand (ng/ml)
CLIA Linearity
Summary: There is an excellent correlation between Fapon's pairing values and the reagent values of international top brand.
Summary: Fapon's PGII exhibits excellent linearity, with a linear range of 1-100 ng/ml and R² of 0.999.
19 Fapon Biotech Inc.
y = 1.043x + 0.6835R² = 0.976
y = 5577.9x +1385.6R² = 0.999
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20Fapon Biotech Inc.
CA125 Antibody
Recommended Pairing
The antigenic determinant of CA125 is associated with a large molecular
weight glycoprotein of the ovarian cavity epithelium during embryonic
development. CA125 can be used to detect common non-mucinous
epithelial ovarian cancers, but it may not be helpful in the detection of
endometrial carcinoma and clear cell carcinoma.
CA125
Catalog No.
BECCA125S105
BENCA125S101
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
BECCA125S105
Coating
IgG2a
BECCA125S108
Coating
IgG1
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BENCA125S101
Labeling
IgG1
BECCA125S104
Coating
IgG1
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
0
50
100
150
200
250
300
0 50 100 150 200 250 300
CA125 Clinical CorrelationFA
PON
's V
alue
(u/m
l)
Reagent Value of International Top Brand (U/ml)
0200000400000600000800000
100000012000001400000160000018000002000000
0 1000 2000 3000 4000 5000 6000
CA125 CLIA Linearity
Antigen Concentration (U/ml)
Val
ue
Pairing Antigen
Clinical Correlation
CLIA Linearity
Summary: There is a good linear correlation between Fapon's CA125 and the reagent values of international top brand.
Summary: Fapon's CA125 exhibits excellent linearity with a linear range of 2-5000 U/ml and R² of 0.993.
21 Fapon Biotech Inc.
GENCA125N101Native
For immunoassays or calibrators0.9% NaCl + protective protein
-20℃ ± 5℃3 years
Catalog No.Host
UsageBu�er
Storage TemperatureShelf Life
y = 371.87x + 17668R² = 0.993
y = 1.012x - 16.309R² = 0.920
CA199 Antibody
Recommended Pairing
CA199 is a tumor marker in colorectal cancer and pancreatic cancer. The
quantitative detection and auxiliary monitoring of serum CA199 levels in
patients with pancreatic cancer have been approved by the FDA. CA199
aids the post-operative monitoring of pancreatic cancer and colorectal
cancer. Elevated CA199 levels indicate tumor recurrence, which can be
detected 1-7 months earlier than ultrasound and clinical diagnosis. Therefore,
CA199 serves as an important indicator that reflects the prognosis of
patients and determine whether they have relapsed after surgery.
CA199
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22Fapon Biotech Inc.
BECCA199S103
Coating
IgM
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BECCA199S104
Coating
IgG1
BECCA199S104
Labeling
IgG1
Catalog No.
BECCA199S104
BECCA199S104
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
Catalog No.
BECCA199S104
BECCA199S103
Recommended Usage
Labeling
Coating
Application Platform
ELISA/CLIA
-1000
0
1000
2000
3000
4000
5000
0 1000 2000 3000 4000 5000
CA199 Clinical CorrelationFA
PON
's V
alue
(U/m
L)
Reagent Value of International Top Brand (U/mL)
CLIA Linearity
Clinical Correlation
Summary: There is a good linear correlation between Fapon's CA199 and the reagent values of international top brand.
Summary: Fapon's CA199 exhibits excellent linearity, with a linear range of 1.2-5000 U/ml and R² of 0.999.
23 Fapon Biotech Inc.
y = 0.9925x + 20.182R² = 0.878
GENCA199N101Native
For immunoassays or calibrators0.9% NaCl + protective protein
-20℃ ± 5℃3 years
Catalog No.Host
UsageBu�er
Storage TemperatureShelf Life
Pairing Antigen
CA199 CLIA Linearity
Antigen Concentration (U/ml)
Val
ue
y = 386.96x + 1184.1R² = 0.999
0
500000
1000000
1500000
2000000
2500000
0 1000 2000 3000 4000 5000 6000
Studies have found that HE4 sensitivity to early ovarian cancer can reach
as high as 45.9% at 95% specificity compared with benign diseases. HE4
levels decrease after ovarian cancer surgery and increase as early as 30
weeks before clinical recurrence. HE4 levels are highly associated with
disease progression in ovarian cancer patients. Therefore, HE4 serves as
an important indicator for the post-operative follow-ups on ovarian
malignant tumors as well as a sensitive indicator for the monitoring of
early recurrence.
HE4
HE4 Antibody
Recommended Pairing
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24Fapon Biotech Inc.
Catalog No.
BECHE4S102
BEJHE4S102
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
BEJHE4S102
Labeling
IgG1
Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BECHE4S102
Coating
IgG2a
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
CLIA Linearity
Clinical Correlation
0
50000
100000
150000
200000
250000
0 500 1000 1500 2000
CLIA Linearity of HE4
Valu
e
Antigen Concentration (pmol/L)
Summary: There is a good linear correlation between Fapon's HE4 and the reagent values of international top brand.
Summary: Fapon's HE4 exhibits excellent linearity, with a linear range of 15-1500 pmol/l and R² of 0.993.
25 Fapon Biotech Inc.
0
200
400
600
800
1000
1200
1400
1600
0 500 1000 1500
HE4 Clinical Correlation
Reagent Value of International Top Brand (pmol/L)
FAPO
N's
Valu
e (p
mol
/l)
y = 1.0087x - 1.6807R² = 0.981
y = 137.91x + 5716.4R² = 0.993
Pairing Antigen
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26Fapon Biotech Inc.
For immunoassays or calibrators20mM PB + protective protein, pH7.4
11 kD6.03
-20℃ ± 5℃3 years
E.coliCatalog No.
HostUsageBu�er
Molecular WeightIsoelectric Point
Storage TemperatureShelf Life
GENHE4N101
CA50 is a tumor marker for pancreatic cancer and colorectal cancer. The
normal reference levels of serum CA50 vary with different measurement
methods and usually fall within the range of 14-20 kU/L. Elevated CA50
levels are indicative of benign pancreatic diseases (12%-46%),
cholangiopathies (35%-38%), and liver diseases (22%-59%). CA50 has a
positive rate of 80%-97% in the diagnosis of pancreatic cancer. Its positive
rate in the diagnosis of rectal cancer varies according to the severity of the
disease: Dukes' A19%-43%, B30%-59%, C53%-73%, D53%-73%. The
positive rate of elevated CA50 levels also varies according to the type of 40
gastric cancer, 58%-70% in cholangiocarcinoma, and 14%-78% in liver
cancer. The positive rate of elevated CA levels is lower in patients with
other malignant tumors (including breast cancer, lung cancer, kidney
cancer, prostate cancer, bladder cancer, ovarian cancer, etc.).
CA50
CA50 Antibody
Recommended Pairing
27 Fapon Biotech Inc.
Catalog No.
BENCA50S101
BENCA50S101
Recommended Usage
Coating/Labeling
Application Platform
ELISA/CLIA
BENCA50S101Antibody
Usage
Subtype
Bu�er
Storage Condition
Shelf Life
Purity
BENCA50S101
Coating/Labeling
IgM
10mM PB + 150mM NaCl + 0.08%NaN3, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
A GLOBAL LEADING IVD REAGENT RAW MATERIALS AND ONE-STOP SOLUTIONS PROVIDER
28Fapon Biotech Inc.
Pairing Antigen
CLIA Linearity
0
200000
400000
600000
800000
1000000
1200000
1400000
1600000
1800000
0 50 100 150 200 250
CA50 CLIA Linearity
Valu
e
Antigen Concentration (U/ml)
Summary: Fapon's CA50 exhibits excellent linearity, with a linear range of 0.37-273.3 U/ml and R² of 0.997.
y = 7725.4x + 3923.6R² = 0.997
GENCA50N101
Native
For immunoassays or calibrators
0.9% NaCl + protective protein
-20℃ ± 5℃
3 years
Catalog No.
Host
Usage
Bu�er
Storage Temperature
Shelf Life
By radioimmunoassay, the positive rate of serum AFP in patients with
primary liver cancer ranges is between 60%-85%. High incidences of liver
cancer have been proven to occur in case of serum AFP concentration
> 200 ug/L, which persists for more than 8 weeks, or when serum AFP
concentration reaches 300-500 ug/L, which persists for 2-4 weeks or even
goes higher after the medical reexamination. Changes in AFP levels in
primary liver cancer should be observed after surgery or chemotherapy. In
general, AFP should return to normal levels within 2 months. If the AFP
level rises again following a decrease, it may indicate incomplete treatment
or recurrence. If the AFP level remains high, fluctuates or increases after
treatment, it indicates a worsening condition and a poor prognosis.
AFP
AFP Antibody
Recommended Pairing
29 Fapon Biotech Inc.
Catalog No.
BECAFPS102
BECAFPS107
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years≥90%
AntibodyUsage
SubtypeBuffer
Storage Condition
Shelf LifePurity
BECAFPS101
Labeling
IgG1
BECAFPS103
Labeling
IgG1
BECAFPS104
Coating
IgG1
BECAFPS102
Coating
IgG1
BECAFPS107
Labeling
IgG1
BECAFPS105
Labeling
IgG1
BECAFPS106
Labeling
IgG1
Clinical Correlation
0
200
400
600
800
1000
1200
1400
1600
0 200 400 600 800 1000 1200 1400
FAPO
N's
Valu
e (n
g/m
l)
Reagent Value of International Top Brand (ng/ml)
AFP Clinical Correlation
CLIA Linearity
0
1000000
2000000
3000000
4000000
5000000
6000000
7000000
0 200 400 600 800 1000 1200 1400
AFP CLIA Linearity
Valu
e
Antigen Concentration (ng/ml)
Pairing Antigen
Summary: There is an excellent linear correlation between Fapon's AFP and the reagent values of international top brand.
Summary: FAPON's AFP exhibits excellent linearity, with a linear range of 0.484-1210 ng/ml and R² of 0.991.
A GLOBAL LEADING IVD REAGENT RAW MATERIALS AND ONE-STOP SOLUTIONS PROVIDER
30Fapon Biotech Inc.
GENAFPN101Native
For immunoassays or calibrators0.9% NaCl + protective protein
-20℃ ± 5℃3 years
Catalog No.Host
UsageBu�er
Storage TemperatureShelf Life
y = 0.944x + 24.835R² = 0.953
y = 4895.5x + 69253R² = 0.991
CEA Antibody
Recommended Pairing
CEASerum CEA has a high positive rate in the detection of digestive tract
malignancies such as colon cancer, rectal cancer, gastric cancer, esophageal
cancer, gallbladder cancer and pancreatic cancer. The maximum detection
rate of colorectal cancer is 74%, while the average range is between
50%-66%. Serum CEA levels may also rise in patients with certain non-digestive
tumors such as lung cancer, breast cancer, ovarian cancer and prostate
cancer.
31 Fapon Biotech Inc.
Catalog No.
BECCEAS103
BENCEAS103
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
BECCEAS102
Coating
IgG1
BENCEAS101
Labeling
IgG1
BECCEAS101
Coating
IgG1
BENCEAS103
Labeling
IgG1
BECCEAS103
Coating
IgG1
AntibodyUsage
SubtypeBuffer
Storage ConditionShelf Life
Purity
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
Clinical Correlation
0
200
400
600
800
1000
1200
1400
1600
0 500 1000 1500 2000
CEA Clinical Correlation
FAPO
N's
Valu
e (n
g/m
l)
Reagent Value of International Top Brand (ng/ml)
CLIA Linearity
0
100000
200000
300000
400000
500000
600000
700000
0 200 400 600 800 1000 1200
Antigen Concentration (ng/ml)
CEA CLIA Linearity
Valu
e
Summary: There is an excellent linear correlation between Fapon's CEA and the reagent values of international top brand.
Summary: Fapon's CEA exhibits excellent linearity, with a linear range of 0.4-1000 ng/ml and R² of 0.999.
A GLOBAL LEADING IVD REAGENT RAW MATERIALS AND ONE-STOP SOLUTIONS PROVIDER
32Fapon Biotech Inc.
y = 636.72x + 1608.8R² = 0.999
y = 0.7275x + 19.505R² = 0.959
Pairing Antigen
33 Fapon Biotech Inc.
GENCEAN101
Native
For immunoassays or calibrators
0.9% NaCl + protective protein
-20℃ ± 5℃
3 years
Catalog No.
Host
Usage
Bu�er
Storage Temperature
Shelf Life
PSAMore than 85% of patients with prostate cancer have elevated blood levels
of PSA. However, elevated PSA levels may also indicate benign prostate
conditions. It can be used in conjunction with other tests to determine early
prostate cancer. The serum PSA levels should be halved within 2-3 days
after prostate cancer surgical treatment. If no significant decrease is
observed after one week, residual cancer tissue may still be present. If
post-operative levels increase rather than decrease, the patient may suffer
from distant metastasis, in particular, bone metastasis, as well as a poor
prognosis.
PSA Antibody
A GLOBAL LEADING IVD REAGENT RAW MATERIALS AND ONE-STOP SOLUTIONS PROVIDER
34Fapon Biotech Inc.
BECPSAS103
Coating
IgG1
BECPSAS101
Coating
IgG1
BECPSAS102
Coating
IgG1
BENPSAN101
Labeling
IgG1
BENPSAN102
Labeling
IgG1
AntibodyUsage
SubtypeBuffer
Storage ConditionShelf Life
Purity
10mM PB + 150mM NaCl + 0.1% Proclin300, pH7.4
-20℃ ± 5℃
3 years
≥ 90%
-200
0
200
400
600
800
1000
1200
1400
0 100 200 300 400 500 600 700
Reagent Value of International Top Brand (ng/ml)
FAPO
N's
Valu
e (n
g/m
l)
PSA Clinical Correlation
Recommended Pairing
Clinical Correlation
CLIA Linearity
-500000
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
4000000
0 20 40 60 80 100 120
PSA CLIA Linearity
Valu
e
Antigen Concentration (ng/ml)
Summary: There is an excellent linear correlation between Fapon's PSA and the reagent values of international top brand.
Summary: Fapon's PSA exhibits excellent linearity, with a linear range of 0.1-100 ng/ml and R² of 0.999.
35 Fapon Biotech Inc.
Catalog No.
BECPSAS103
BENPSAN101
Recommended Usage
Coating
Labeling
Application Platform
ELISA/CLIA
y = 34027x - 436.44R² = 0.999
y = 2.0146x - 11.882R² = 0.969
Fapon Biotech Inc.No.5 Hualian RD, Taiwan High-tech Industrial Park, Songshan Lake, Guangdong, 523808 China
+86-769-22898886
+86-769-22898886-8800
RMTM-INMK-201910 LinkedIn: faponbiotech