rationale: why do we still need a large trial? ist-3 the third international stroke trial: national...
TRANSCRIPT
![Page 1: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/1.jpg)
Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial:
National Coordinators’ Meeting25 May 2005, Bologna
Professor Richard Lindley, Co-Principal Investigator
![Page 2: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/2.jpg)
Outline
• Why large trials?• Why do we need more randomised
evidence?– Small evidence base– Variation in clinical practice
• Areas of uncertainty • Current trials• IST3 design
![Page 3: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/3.jpg)
Rationale for large trials
• Acute ischaemic stroke treatment currently unsatisfactory
• Aspirin effective but has only modest benefit (approximately 1% absolute benefit) BUT currently has a greater public health impact than thrombolysis (large number of patients treated with a modestly effective treatment)
• Thrombolysis proven to be effective for only highly selected patients (10-15% absolute benefit) BUT few treated and minimal public health benefit (small number of patients treated with a powerful treatment)
![Page 4: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/4.jpg)
History of acute stroke trials
• Modern era dependent on wide-spread availability of CT (and MRI) scanners, therefore a short history
• Only two “mega-trials” IST and CAST• Industry dominated acute stroke trials all
seriously underpowered (in comparison to secondary prevention stroke trials)
![Page 5: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/5.jpg)
Lubeluzole
• N = 3510 patients, confidence interval for death or dependency at the end of follow-up 0.91 to 1.19
• Trials only powered to detect a 10-15% absolute benefit
![Page 6: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/6.jpg)
Gavestinel (GAIN trials)
• GAIN Americas, 90% power to detect a 10% absolute benefit (n = 1646), 2% absolute benefit observed for independent survival BUT 4% more dead
• GAIN International, 90% power to detect a 6-10% absolute benefit (n=1800), - 0.8% absolute benefit observed for independent survival and 1.6% more dead (95% CI for odds ratio for worse outcome 0.81 to 1.26)
![Page 7: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/7.jpg)
Trials in acute stroke are far too small
“It is still not sufficiently widely appreciated just how large clinical trials need to be to detect reliably the sort of moderate, but important, differences in major outcomes that might exist (especially if effects in different subgroups are to be assessed reliably).”
Collins and MacMahon Lancet 2001; 357: 373-380
![Page 8: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/8.jpg)
Neuroprotectors unlikely to have a major treatment benefit
You need to OPEN occluded arteries
![Page 9: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/9.jpg)
With trials of about 20,000 subjects, the pharmaceutical industry can be reassured that they have not missed an important new treatment for acute stroke
![Page 10: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/10.jpg)
Worthwhile reductions in stroke death and disability
60% dead or disabled at six months in control group
58% dead or disabled at six months in treatment group
Sample size Power
5000 50%
9000 80%
13000 90%
16000 95%
![Page 11: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/11.jpg)
Lessons from cardiology
ISIS-2 Mortality in placebo group 13%
Trial Mortality in best treatment arm
ISIS-2 8%
ISIS-4 7%
GUSTO 6%
Message: Moderate cumulative treatment effects halved MI mortality over a 10 year period
![Page 12: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/12.jpg)
Lessons from stroke medicine
IST Death/dependency in control group 64%
Trial Death/dependency in best treatment arm
IST 63% (aspirin)
Stroke units 58%
rt-PA 58% (i.e. current negligible impact)
Message: Moderate cumulative treatment effects have potential impact in stroke
![Page 13: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/13.jpg)
Lessons from cardiology
ISIS-1 1986 16,000 patients
ISIS-2 1988 17,000 patients
ISIS-3 1992 40,000 patients
GUSTO 1993 41,000 patients
ISIS-4 1995 60,000 patients
![Page 14: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/14.jpg)
Thrombolytic Time Window: Acute MI
Fibrinolytic Therapy Trialists’ Group. Lancet 1994;343:311-322
60,000 patients from “mega-trials”
![Page 15: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/15.jpg)
Thrombolysis for acute ischaemic stroke
• Standard accepted treatment for MI
• Slow acceptance for acute stroke
![Page 16: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/16.jpg)
NINDS Trial Published in 1995• 624 patients• Clinical inclusion
criteria• CT scan to exclude a
bleed or mimic (no other exclusions)
• Treatment to begin within 3 hours of stroke
• i.v. rt-PA 0.9mg/kg over 1 hour
• Major treatment effect 120-160 more independent survivors per 1,000 treatment
• Independent re-analysis 2003 confirms results
• 10 years later treatment not widely implemented
![Page 17: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/17.jpg)
ECASS II Published in 1998• 800 patients 18 to 80
years• Clinical inclusion criteria• CT scan to exclude a
bleed, mimic and > 1/3 MCA ischaemia)
• Treatment to begin within 6 hours of stroke
• i.v. rt-PA 0.9mg/kg over 1 hour
• Non-significant modest benefit 37 more independent survivors per 1,000 treatment
• 7 years later treatment not implemented for 3-6 hour time window
![Page 18: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/18.jpg)
ECASS II Published in 1998
• Powered to detect a 10% absolute difference with 80% power
• Detected a 3.7% absolute difference
![Page 19: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/19.jpg)
ECASS III Currently recruiting
• Aged 18 to 80 years
• 800 patients recruited 3-4 hours post stroke
• Still powered to detect a 10% absolute difference, this time with 90% power
![Page 20: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/20.jpg)
Evidence
![Page 21: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/21.jpg)
Randomised trials of thrombolysis vs control in acute myocardial infarction
Total no. patients 1994 58,600
Randomised trials trials of thrombolysis vs control in acute ischaemic stroke
Total (all agents) 2005 5,675
rt-PA 2005 2,700
rt-PA < 3hrs 2005 930
rt-PA aged > 80 years 42
![Page 22: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/22.jpg)
i.v. rt-PA benefit <6 hours: reduction in ‘death or dependency’
20% reduction with rt-PA (95% CI 7-23%)BUT the significant between- trial
heterogeneity (I2=62%) makes result unreliable
![Page 23: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/23.jpg)
Unacceptable variation in usage in clinical practice
![Page 24: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/24.jpg)
Only a small, variable proportion of patients get rt-PA in USA, Germany
Author no. no. % treated hospitals patients rt-PA (range)
USAJohnstone 42 1,195 4.1% (0-12%) Furlan 29 3,948 1.8% (0-10%) Reed 137 23,058 1.6% (0-5%)
GermanyHeuschmann 104 13,440 3.0% (0-18%)
![Page 25: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/25.jpg)
Effect of hospital, age and presence of neurologist on likelihood of receiving
thrombolysis for acute ischaemic stroke among 23,058 acute stroke patients from 137
community hospitals in USA
• In 35% of hospitals, no patients at all given rt-PA.
• Strong trends to less rt-PA use:– with increasing age,
– if no neurologist available
Reed et al. Stroke 2001: 32; 1832-44
![Page 26: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/26.jpg)
Variation in use of rt-PA for acute ischaemic stroke ‘within licence’ in Europe
0
10
20
30
40
50
60
rt-P
A f
or
str
ok
e p
er
millio
n p
op
'n
Finland
Austria
SwedenNorway
Belgium
Spain
GermanyNetherlands
Denmark
Italy
UK
GreeceFrance
Portugal
SITS register (2003-5) March 2005
![Page 27: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/27.jpg)
‘Grey areas’ of uncertainty: i.v. rt-PA promising but unproven
for patients who:
• Present < 3hrs & do not exactly meet NINDS criteria
• All patients 3-6hours
• Older patients (>75 years)
• Severe stroke, mild stroke…...
• Have subtle, early ischaemic change on CT
• Etc etc …
![Page 28: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/28.jpg)
Sample size required to answer these questions about iv rt-PA reliably
rt-PA study group. Lancet 2004; 363: 768–74
0-1.5 1.5-3.0 3.0-4.5 4.5-6.0hours
![Page 29: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/29.jpg)
Current trials
![Page 30: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/30.jpg)
Current randomised trials of i.v. thrombolysis
Trial Thrombolytic
agent Patient selection trial size & time window
EPITHET rt-PA Clinical, CT (+ DWI/PWI MRI) 3-6 hours 100 patients
DIAS -2 Desmoteplase DWI/PWI or CT perfusion 3-9 hours 186 patients
ECASS III rt-PA Clinical and CT 3-4 hours 800 patients
![Page 31: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/31.jpg)
Small (n< 300) trials of other interventionsIA thrombolysis
MELT
SYNTHESIS
GP IIb/IIIA
AbESTT2 (n=1800)
CLEAR
ROSIE
SETIS
SATIS
Mechanical
MR-RESCUE
Ultrasound +/- rt-PA
CLOTBUST-2?
MUST
![Page 32: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/32.jpg)
None of these trials will reliably answer the main
questions
![Page 33: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/33.jpg)
IST - 3 Protocol
Main features of IST - 3 • International, multi-centre, Prospective,
Randomised, Open, Blinded Endpoints study of i.v. rt-PA vs control.
• Target 6000 patients • Primary outcome: the proportion of patients alive
and independent at six months (Modified Rankin 0,1 or 2)
• Central telephone randomisation with on-line minimisation to balance key prognostic factors.
• Web-based blinded detailed central review of all scans (ASPECTS, 1/3 MCA rule, dense MCA etc)
• Conducted to EU GCP standards.
![Page 34: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/34.jpg)
IST - 3 Protocol
IST-3 Sample size: 6,000 patients
• 1500 patients randomised within 3 hours will give >95% power (alpha 0.05) to detect a 10% increase in the proportion of patients alive and independent at 6 months (40% to 50%).
• 4500 patients randomised from 3 to 6 hours will give >90% power (alpha 0.05) to detect a 5% increase in the proportion of patients alive and independent at 6 months (40% to 45%).
![Page 35: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/35.jpg)
IST-3 main eligibility criteria• Symptoms and signs of clinically
definite acute stroke• Time of onset of stroke is known and
treatment can be started within 6 hours of this onset
• CT or MRI has reliably excluded both intracranial haemorrhage and structural brain lesions which can mimic stroke
• Fuller details at: www.ist3.com
![Page 36: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/36.jpg)
IST-3 main exclusion criteria
• Major surgery, trauma,GI or urinary tract haemorrhage within previous 21 days
• Arterial puncture at a non-compressible site within the previous 7 days
• Any known coagulation defect
• Hypo- or hyperglycaemia sufficient to account for neurological symptoms
![Page 37: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/37.jpg)
Early infarct signs on CT
4 hours 24 hours
Hypodensity : loss of grey/white differentiation, loss of the lentiform nucleus
Swelling : effacement of sulci, squashing the ventricle
![Page 38: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/38.jpg)
web-based CT reading and feedback system:
• Log on to www.neuroimage.co.uk
• Register
• Do first 20 scans (2 batches)- get 1 CPD credit-get feedback
•Do all six batches - get 5 CPD credits
IST-3: Training to read CT scans
what you, the reference standard, five experts and all other specialties said about that scan, and a follow-up scan to see where the infarct appeared
![Page 39: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/39.jpg)
IST-3 Imaging: Training materials to read scans
![Page 40: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/40.jpg)
IST-3 Imaging: Training materials to read scans
![Page 41: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/41.jpg)
IST-3 trial: randomisation
If patient fits main eligibility/exclusion criteria,
Clinician/patient/family discuss. If:
• Clear INDICATION FOR rt-PA TREAT (i.e. meets terms of current licence and patient agrees)
• Clear CONTRAINDICATION TO rt-PA DON’T TREAT
• rt-PA ‘PROMISING BUT UNPROVEN’ RANDOMISE
![Page 42: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/42.jpg)
Conclusion. Need to• Implement existing knowledge: redesign services to
increase equity of access to thrombolysis within licence
• Increase the evidence base; worldwide effort to randomise sufficient patients to in IST-3 (and other trials) to provide reliable evidence on current questions
• Be aware of benefits of participating in IST-3:– It helps address a ‘real world’ intervention– You will get education on acute stroke care/CT scanning– If the trial result is positive, active trial centres more likely
to be able to adopt new treatment quickly
![Page 43: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/43.jpg)
New UK centres needed: please encourage other centres to join the trial
register at www.ist3.com
![Page 44: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/44.jpg)
Can we get 10-20% of ischaemic stroke treated with rt-PA?
999
Nurse led Stroke Management
process - Evaluation and
Triage
Within 6 Hrs
![Page 45: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/45.jpg)
To achieve this we need seriously reliable data on:
• Treatment effect to 6 hours (and maybe beyond)
• Treatment effects by age, stroke subtype, severity, presence of aspirin and early ischaemic change on CT etc
![Page 46: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/46.jpg)
Such change requires a convincing trial! Impact of megatrials in cardiology on thrombolysis for MI
![Page 47: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/47.jpg)
IST-3: The window of opportunity
• In 1998 acute stroke services were too under-developed for a thrombolysis “mega-trial”
• Stroke services world-wide are being developed and maturing
• rt-PA has a track record in an “effective but not useful” time window
• It is now the most promising treatment to evaluate
![Page 48: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/48.jpg)
IST-3: Streamlined design
• Methodology of large simple stroke trial developed over 15 years
• IST-3 designed with consumers and collaborative group
• Central organisation and delegated responsibilities share as much of the work as possible
• Evidence based trial monitoring!
![Page 49: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/49.jpg)
IST-3 is simple & streamlined! Compare the paperwork needed for AbESTT-2 trial vs IST-3
AbESTT-2 IST-3
![Page 50: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/50.jpg)
So we need hospital teams to be treating stroke as an emergency…
…and not lounging around drinking coffee!
![Page 51: Rationale: Why do we still need a large trial? IST-3 The Third International Stroke Trial: National Coordinators’ Meeting 25 May 2005, Bologna Professor](https://reader036.vdocuments.mx/reader036/viewer/2022062314/56649eca5503460f94bd8119/html5/thumbnails/51.jpg)