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ras-raf- mek

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Ras-raf- MEK AKT PI3K PTEN mTOR TSC 2 TSC 1 LKB1 AMPK TORC1 TORC2 mTOR mTORC1/2 inhibitors Tyrosine kinase inhibitors AKT inhibitors Metformine Rapalogs: Everolimus Temsirolimus ridaforolimus PI3K inhibitors PI3K dependent pathway AMPK-dependent PI3K independent pathway ENERGY PATHWAY

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AMPK-dependent PI3K independent pathway ENERGY PATHWAY. Tyrosine kinase inhibitors. PI3K dependent pathway. Ras-raf- MEK. AKT inhibitors. LKB1. PI3K inhibitors. PI3K. PTEN. AMPK. AKT. TORC2. mTOR. Metformine. TSC2. TSC1. mTORC1/2 inhibitors. TORC1. mTOR. Rapalogs : - PowerPoint PPT Presentation

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Page 1: Ras-raf- MEK

Ras-raf-MEK

AKT

PI3K

PTEN

mTOR

TSC2 TSC1

LKB1

AMPK

TORC1

TORC2mTOR

mTORC1/2 inhibitors

Tyrosine kinase inhibitors

AKT inhibitors

Metformine

Rapalogs:Everolimus

Temsirolimusridaforolimus

PI3K inhibitors

PI3K dependent pathway

AMPK-dependentPI3K independent pathway

ENERGY PATHWAY

MFB | RAF MFB MFB | RAF · mfb mfb | raf mfb | raf mfb | raf mfb | raf mfb | raf mfb | raf mfb | raf mfb | raf 1.55 mfb | raf mfb | raf mfb | raf 180/80 lift nr.: 03 nische a 4.40

Ras-Raf-MAPK SHCGrb2SOS1 P P P Raf1 P MEK2 P MEK1 P Grb2, growth factor receptor-bound protein 2 Ras ERK2 ERK1

E Acute Lymphoblastic Leukemia CREBBP knockdown … · enhances signaling of the RAS/RAF/MEK/ERK pathway in Ras pathway mutated acute lymphoblastic leukemia cells, which are still

MEK inhibitor trametinib does not prevent the growth of ... · Activation of the RAS-RAF-MEK-ERK signaling pathway is implicated in driving the initiation and progression of ... We

Ras-Raf MM PB(GB)SA Tutorial: AMBER 8ambermd.org/tutorials/advanced/tutorial3/pdfs/amber...Ras-Raf MM_PB(GB)SA Tutorial: AMBER 8 Bethany L. Kormos and David L. Beveridge* Department

EUnetHTA WP5 Joint Action 2 (2012-2015) Strand … the RAS/RAF/MEK/ERK pathway). [B0001] It has been approved by the European Medicines Agency (EMA) and the US Food and Drug Administration

Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK ... · pathway, and cross-talk to reactivate the PI3K pathway. Combinations of PI3K pathway and MAP–ERK kinase (MEK) inhibitors

Mathematical Modeling of the Influence of RKIP on the ERK ... · The Ras/Raf-1/MEK/ERK module is a ubiquitously expressed signaling pathway that conveys mitogenic and differentiation

Research Article Moxibustion Inhibits the ERK Signaling ...moxibustion group. It indicates that Ras, Raf-, MEK-, and ERK-/ are involved in the process of intestinal brosis in CD rats

AurkA inhibitors enhance the effects of B-RAF and MEK ...B-RAF (V600E) inhibitors (e.g. vemurafenib, dabrafenib) [11] were the first targeted therapy in melanoma and have been associated

RTK Signal Transduction - Limes-Institut-Bonn · GTP-Ras triggers the MAP-Kinase cascade via three enzymatic steps: 1. Raf(Ras-activated factor) 2. MEK(MAP/ERK-Kinase, also MAP-Kinase-Kinase)

Activation Raf-1/MAP transformation RIE-1 epithelial · brane-targeted Raf-1 (Raf-CAAX) suggests that Ras trans-formation is triggered primarily by a Ras-mediated translo-cation ofRaf-1

MELANOMA Changing Landscape - WIN 2018 … · Molecular Alterations in Melanoma FGFR PTEN PI3K Akt TOR KIT GRB2 SOS Ras GDP C-Raf N-Ras GTP B-Raf MEK ERK ELK MITF CDK2/4 Cyclin D

Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and … · Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer Payton D. Stevens 1 ,Yang-An Wen

Potassium Channel Induction By the Ras/Raf Signal Transduction

The ofthe Raf-1 Ras and · (NMR)(12), andthestructureofRBS-1inacomplexwiththe Ras-related protein RaplA has also been solved by x-ray crystallography(13). Inaddition, it hasbeenshownthat

Novel Cancer Therapeutics with Allosteric …precision medicine. Besides the canonical Ras–Raf–MEK–ERK signaling pathway, Raf proteins also participate in the regulation of mitochondrial

Roles of the Ras&Raf&MEK&ERK pathway in leukemia therapy · REVIEW Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy LS Steelman1,2, RA Franklin 1, SL Abrams , W Chappell ,

Future targeting of the RAS/RAF/MEK/ERK signaling pathway in … · 2020. 1. 5. · Future targeting of the RAS/RAF/MEK/ERK signaling pathway in oncology: the example of melanoma

ALVO: Receptores de morte das vias da Apoptose · Akt/PKB Growth Survival Division Motility RAF MEK ERK RAS PI3-K mRNA Translation Cytokine Receptor Gene Transcription mTOR ER Growth

C-Raf Is Required for the Initiation of Lung Cancer by K-Ras...absence of B-Raf elevated proliferation of B-Raf Δ/Δ; K-RasG12D BMK cells (Fig. 2B). These data indicate that B-Raf

Interruption of the Ras/MEK/ERK signaling cascade - Blood

Rational combination therapy with PARP and MEK inhibitors ...Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers

Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a ... · Autoinhibition is similarly common upstream and down-stream Ras signaling cascades. Like all kinases,unbound epi-dermal

Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance …mct.aacrjournals.org/content/molcanther/14/12/2700.full.pdf · Small Molecule Therapeutics Combined Pan-RAF and

Dissecting the roles of Raf- and PI3K-signalling …the Raf-Mek-Erk pathway is distinct among Ras effector pathways in being able to initiate melanocyte neoplasia and demonstrate,

Pan-RAF Inhibition Shows Anti-Leukemic Activity in RAS

Pan-RAF and MEK vertical inhibition enhances therapeutic … · 2018. 5. 17. · therapeutic strategy in vitro in NRAS mutant melano-mas, when RAS/RAF/MEK/ERK pathway is activated

Cystine/glutamate antiporter xCT (SLC7A11) facilitates ... · the Ras-Raf-Mek-Erk pathway by the Ets-1 transcription factor which, in synergy with Atf4, directly transactivates the

RAS RAF MEK ERK Der MAPK-Signalweg. Übersicht Der MAPK-Signalweg: –Übersicht –Signaltransduktion Dysregulierter MAPK-Signalweg –Bei Tumorkrankungen allgemein

Dia 1 - NIV | Nederlands internisten vereniging Snapper 2017.pdf · 19-6-2017 6 Monoclonale antilichamen EGFR - Ras pathway Panitumumab Cetuximab BRAF remmers MEK inhibitors RAS mutatieEGFR

NCI RAS Initiative Update...• No structural insights about how RAS activates Raf kinase. • No structural information on full -length processed RAS. • No structural information

MEK1 mutations confer resistance to MEK and B-RAF inhibition · MEK1 mutations confer resistance to MEK and B-RAF inhibition Caroline M. Emerya,b, Krishna G. Vijayendrana,b, Marie

Systems Biology - sbi.uni-rostock.de · Ras/Raf-1/MEK/ERK pathway.The figure is read from left to right: from growth factor stimulation of the receptors, recruitment of Raf-1 and

Review Article Targeting the HGF-cMET Axis in ... · InternationalJournalofHepatology Ras MEK Raf ERK PI3K mTOR FAK AKT MET EGFR family members HGF Survival Proliferation Invasion