FOCUS AREAS: Hip, knee, spine, trauma, & forging, casting, machining, coating, packaging, sterilization, ceramics, instruments, cases & trays

PUBLICATION DATE: July 2017

OVERVIEW:

This report contains 375+ pages, 450+ exhibits and 200 company profiles. It provides details of the worldwide orthopaedic Contract Manufacturing market and analysis for the following segments:Forging: Hip stem, hip cup, femoral knee, tibial knee, LF plates, LC platesCasting: Femoral knee, tibial knee, hip cup, hip stem Hip machining & finishing: Stem, cup, head, linerKnee machining & finishing: Insert, tibial, femoral componentsSpine & trauma, machining & finishing: Lumbar Universal Systems, spine plates, spine screws and cages, trauma internal plates, trauma screws and other productsInstrument machining & finishing: Hip, knee, spine, traumaCases & trays: Hip, knee, spine, traumaCoating: Stem, cup, femoral, tibial componentsCeramics: Femoral heads, cup linersMarking, packaging and sterilization: Hip, knee, spine, trauma

Top 200 players with market share in each segment

Orthopaedics Additive Manufacturing market analysis: users, suppliers, products focused on & forecasts

Also details of the following players and segments: • Orthobiologics• Coating• Ceramics• Packaging • Sterilization • Raw materials, Peek, Polyethylene UHMW

THE WORLDWIDE ORTHOPAEDIC CONTRACT MANUFACTURINGMARKET REPORT 2016-2021& TOP 100 SUPPLIER PROFILES

AVICENNE’S

UNIQUE WARRANTY

If you are not 100% satisfied with our

report, send it back to us with a letter indicating

the reasons and we will refund you in full!

PUBLISHED JULY 2017 • 5TH EDITION

Created and chaired by

N E WSpecial Focus on the worldwide

orthopaedic market, player dynamics

and global market shares

Orthopaedics Additive

Manufacturing market analysis :

users, suppliers, products

focused on & forecasts

International conference on innovationfor orthopaedic implants and orthobiologics

20 1 7www.avicenne.comDownload the detailed table of contents

WHY BUY THIS REPORT?

Get accurate figures on the worldwide orthopaedic & Contract Manufacturing market & players

For OEMs : Find your contract manufacturers in USA, Europe and the rest of the world among 200+ top suppliers

For investors & private equity firms : find the right targets for investments

1DETAILED ANALYSIS OF THE WORLDWIDE CONTRACT MANUFACTURING MARKET:

3 OEM CONTRACT MANUFACTURING STRATEGY: THE FOLLOWING DATA AND FIGURES WILL BE PROVIDED FOR EACH MAJOR OEM

2 METHODOLOGY:

PROD

UCT S

EGME

NTAT

ION

HEAD

HIP

LINER

KNEE

SPINE

TRAUMA

CERA

MICS

MPS

OTHE

RS

PROD

UCT S

EGME

NTAT

ION

HIP STEM

HIP CUP

TIBIAL KNEE

LF PLATES

LC PLATES

FEMORAL KNEE(SPECIAL FORGING)

FEMORAL KNEE

TIBIAL KNEE

HIP CUP

HIP STEM

STEM

FEMORAL

CUP

TIBIAL

INSERT

HEAD

LINER

FORG

ING

CAST

ING

HIP M

ACHI

NING

KNEE

MAC

HINI

NG

PROD

UCT S

EGME

NTAT

ION

LUMBAR UNIVERSAL SYSTEMS

SPINE PLATES

TRAUMA INTERNAL PLATES

TRAUMA SCREWS & OTHERS

SPINE SCREWS & CAGES

HIP

KNEE

SPINE

TRAUMA

HIP

STEM

KNEE

CUP

FEMORAL

TIBIA

SPINE

TRAUMA

SPIN

E & TR

AUMA

MA

CHIN

ING

INST

RUME

NTS

MACH

ININ

GCA

SES &

TRAY

SCO

ATIN

G

11 segments and 40 sub-segments are broken down and analyzed & quantified in this report

Manufacturing strategy and data: Stryker

Stryker facilities worldwide & specialties Contract Manufacturing rate Implants, instruments, cases & trays, coating, ceramics, packaging

OEM contract manufacturing needs: Stryker

In-house: forging In-house: casting In-house: machining Contract Manufacturing: forging Contract Manufacturing: casting Contract Manufacturing: machining

OEM Contract Manufacturing needs: Stryker Spine & Trauma machining – In-house: number of units Spine & Trauma machining – Contract Manufacturing: number of units Instrument machining – In-house: number of sets Instrument machining – Contract Manufacturing: number of sets Coating – In-house: number of units Coating – Contract Manufacturing: number of units

Example of but also provided for : Challengers

Source : Avicenne 2016

SURVEY METHODOLOGY

OEM & Contract Manufacturer direct interviews with decision makers thanks to strong links with CEOs, R&D, Marketing, Sales...

Cross-checking of information thanks to our tried & tested operating models

Worldwide coverage

OEM

Hip

Knee

Shoulder

IMPL

ANTS

ZIMMER STRYKER DEPUY SYNTHES

Vol Vol Vol

Y

Val Val ValRowth % %

DEPUY SYNTHES

AVIC

ENN

E SU

MM

ARY

Y a b c d e

Sour

ce 1

: con

tact

1

Sour

ce 1

: con

tact

2

Sour

ce 3

: mar

ketin

g

Sour

ce 4

: Pr

oduc

t Man

ager

Sour

ce 5

: Sa

les M

anag

er

…

DEVELOPED COUNTRIES

BRICCOUNTRIES

DEVELOPING COUNTRIES

Latin America, Middle East, Asia

Western Europe+

20+ years of historical data on the Orthopaedics & Contract Manufacturing markets

Companies & continuous tracking

Highly detailed segmentation

Implants Instruments Cases, trays Biologics

Contract Manufacturing

Entire supply chain & all players: OEMs, Contract Manufacturers

All product types: implants, instruments, cases & trays, biologics, cements, ceramics

All manufacturing services: forging, casting, machining, coating, packaging, sterilization

www.avicenne.comDownload the detailed table of contents

Implants

Hip

Knee

Spine

Extremities

Trauma

Operating Models & Cross-checking of information

By OEM orders

By services & products offered for all segments & sub-segments (volume, value)

By Contract Manufacturing market share & player details:• Implants: Orchid, Tecomet, Marle, Lisi, Paragon, Greatbatch,

Norman Noble, Avalign, PCC, etc. (70+ companies mentioned)• Instruments: Tecomet, Greatbatch, Avalign, Autocam Medical,

Intech, Tegra, Norwood, Bradshaw, etc.(45+)• Cases & trays: Tecomet, Paragon, Greatbatch, Avalign, Pyxidis,

CoorsTek, etc. (20+)Also details of the following players and segments: • Coating: DOT, Eurocoating, APS Materials, Terolab, Medical Group,

Medicoat, etc.• Ceramics: Ceramtec, Metoxit, CoorsTek, Kyocera, etc.• Packaging: Amcor, Bemis, Oliver-Tolas, Millstone, Nelipack, etc.• Sterilization: Steris, Sterigenics, Ionisos, etc.• Orthobiologics: Heraeus, Teknimed, Tecres, AAP Biomaterials,… • Raw materials, Peek, Polyethylene UHMW: Invibio, Solvay,

Evonik, PPD Meditech, etc.

4PRICE DASHBOARDS: FOR EACH SERVICE BY AREA, BY OEM

6CONTRACT MANUFACTURING MARKET HISTORICAL REVENUES & FORECASTS UP TO 2020:

5WORLDWIDE ORTHOPAEDICS CONTRACT MANUFACTURING MARKET & PLAYER DETAILS:

7CONTRACT MANUFACTURING COMPANY RANKINGS & TOP 100 SUPPLIER PROFILES:

Contract Manufacturing average price range in US$ for forging services

USA EUROPE

Forging

Hip stems

Hip cups

Femoral knee

Knee tibia

Trauma LC plates

Hip stems

Hip cups

Femoral knee

Knee tibia

Trauma LC plates

US$ US$

Contract Manufacturing stem forging example prices per customer in US$

Hip stem Forging

Stryker (Lisi)

Depuy (Marle)

Zimmer

Biomet

Smith & Nephew

Challengers

The report analyzes the Contract Manufacturing market for implants, instruments and cases & trays by taking into account the needs of OEMs: In-house or outsourced manufacturing.To forecast the Contract Manufacturing market, we took into account the future needs of OEMs, including any facility divestments.

Implants will grow more rapidly than instruments and cases & trays!

The 2017 and 13th edition of IMPLANTS attracted more than 200 international decision-makers for a full day of presentations, tutorials and business networking. The speakers highlighted how manufacturing techniques and purchasing strategies are evolving, and how additive manufacturing will alter the future landscape. IMPLANTS has become a “must attend” event on the orthopaedics industry calendar.

OUR CONTACT NETWORK OUR ORTHOPAEDICS DATABASE:37,000+ QUALIFIED CONTACTS

Example of profile:

M U

S$

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2020

Instruments Cases & Trays Implants

CAGR 2005-2020: 6.1% CAGR 2015-2020

Implants

Cases

Instr.

International conference on innovationfor orthopaedic implants and orthobiologics

20 1 7

Created and chaired by

www.implants-event.com

Europe10,400+contacts

ContractManufacturers

7,500+contacts

USA18,900+contacts

Example7,600+

decision makers for Spine segment

New database

BRIC, Eastern Europe, Latin

America

Surgeonsdatabase

connections

Updated daily

25 yearsof experience

37,000+ QUALIFIED CONTACTS

US$

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MAIN REPORTWorldwide Orthopaedic Contract Manufacturing Market Report 2016-2021 & Top 100 supplier profiles

TOP 101-200 supplier profiles

NUMBER OF PAGESNUMBER OF EXHIBITS SINGLE-USER LICENSEPRODUCT OPTIONS

275+ pages

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450+ exhibits€4600

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1-HOUR CONFERENCE CALL WITH ALI MADANI Survey Director, Report Author & Avicenne CEODuring this call, Ali will explain the methodology used, present our vision & the trends in the Contract Manufacturing market and answer your questions about the report.

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WORLDWIDE ORTHOPAEDIC CONTRACT MANUFACTURING MARKET REPORT 2016-2021& TOP 100 SUPPLIER PROFILES PUBLISHED JULY 2017 • 5TH EDITION

1 DAY FOLLOW-UP CONSULTING VISIT AT YOUR COMPANY By Ali Madani - Orthopaedics expert & CEO of AvicenneAli founded AVICENNE in 1992. Since 1990 he has been working on strategic and marketing studies in the medical sector. He has advised major players in this industry (Medtronic, Stryker, Zimmer, Depuy, etc.) in terms of strategy development and implementation, technical and economic appraisals and mergers and acquisitions. He has also advised multiple Private Equities firms for acquisitions (> € 50M value) and build-up. He has worked with mid-size companies on their entry strategy for new markets, adjacencies or new geographic territories and also business model improvements and partnership strategies.Globally, he has been involved in more than 300 projects for 100+ customers in the medical devices industry.Ali has published several annual surveys like “European orthopaedic Market” and “Worldwide orthopaedic contract manufacturing market 2015-2020 and top 200 supplier profiles” and he is a speaker and chairman of several medical device conferences worldwide. In 2005, he founded “IMPLANTS” a medical device industry conference and exhibition, which he has presided ever since.

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