randy gollub, md,phd

Randy Gollub, MD,PhD

http://catalyst.harvard.edu May 19, 2009

Overview of the Harvard Catalyst

Imaging program- how to use the resources for

your research

Harvard Catalyst: The History and the Basics

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• GCRC program (20+ yr NCRR/NIH funded clinical research support program) discontinued– MGH Biomedical Imaging Core established 2002

• CTSA 2007(Roadmap initiative)• HU- Response-Harvard Catalyst

– (PI Lee Nadler/Co-Director: Steve Freedman)

• We are a pan-Harvard enterprise dedicated to improving human health by:– Creating Connections– Enabling research At the Cutting Edge of discovery– Nurturing clinical and translational researchers

Imaging Consortium History

• MGH and BWH GCRC Imaging Cores NCRR

– MGH and BWH P41s devoted to medical imaging• Martinos Center for Functional Imaging Technologies (Rosen)• Neuroimage Analysis Center (Kikinis)• Image Guided Therapy (Jolesz)

– Biomedical Informatics Research Network (BIRN) • Morphometry Testbed (Rosen)• Functional Neuroimaging Testbed

NIH NCBC

– National Alliance for Medical Image Computing (NA-MIC) Fee for Service (MGH/BWH/DFCC)

– DFCI Tumor Metrics Core

Institutions participating in Harvard CTSC

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Academic Healthcare Centers• Beth Israel-Deaconess Medical

Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston

Specialty Hospitals and Institutes• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear

Infirmary• McLean Hospital• Schepens Eye Research Institute

Massachusetts Institutes of Technology

Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering

Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory

Care and Prevention at Harvard Pilgrim Healthcare

Blue –Imaging Consortium

Yearly budget: $38 million (23 NIH + 15 matching)

Harvard Catalyst

• Programs (Selected list)

– Translational Technologies (Imaging & Genetics)– Participant and Clinical Interactions Resource (PCIR)– Development of Novel C/T Methodologies– Biomedical Informatics– Pilot studies– Design and Biostatistics (Mark Vangel)– Research Education, Career Development – Diversity and Health Disparities Research– Ethics– Linkages across the institutions– Regulatory Knowledge and Support

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Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, Site Co-Director

Robert Lenkinski, Site Co-DirectorNeil Rofsky, Site Co-Director

Clare Tempany, Site Co-DirectorRon Kikinis, Site Co-DirectorGordon Williams, PI for CTSC Translational Technologies

Stephan Voss, Site Co-DirectorSimon Warfield, Site Co-Director

Annick D. Van den Abbeele, Site Co-DirectorJeff Yap, Site Co-Director

Gordon J. Harris, Site Co-DirectorAnnick D. Van den Abbeele, Site Co-DirectorWilliam Hanlon, Core Manager

Valerie Humblet, Imaging LiaisonYong Gao, Imaging Informatics Architect

Imaging Consortium Team

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Mission of the Imaging Consortium

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• Expand imaging in clinical research:– Build & deploy infrastructure (expertise in single and

cross site image acquisition, image analysis, visualization & data management software tools)

– Provide expert consultation in the use of imaging for clinical translational research

– Educate and advise about available imaging and image processing capabilities in the Harvard environment

– Provide leadership & education at the local and national level

Harvard Catalyst website

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http://catalyst.harvard.edu/home.html

http://catalyst.harvard.edu/




Image Consortium Consultation Service

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Image Consortium Consultation Service

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Technologies and Expertise

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• Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging.

• Focused on assisting with planning and design of research proposals and/or methods for image analysis.

• Consultation is available for the preparation of a grant or IRB submission.

• We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies.

Example of Imaging Consultation

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• Study of brain-development in premature infants (new collaboration: CHB-BWH-MGH)

Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation

in Infants (MGH)

CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center

Pilot funds

• Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation.

• First round: 62 projects funded (out of 602)• Funds:

Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected)

• Deadlines:Letter of intent: May 13, 2009

Full application: June 12, 2009• Contact:

Harvard Catalyst Research Navigators617 432-7800

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MGH Biomedical Imaging Core

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MGH Biomedical Imaging Corehttp://www2.massgeneral.org/crc/bic/index.htm

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MGH Biomedical Imaging Core http://www2.massgeneral.org/crc/bic/index.htm

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TMS


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MGH BIC Imaging Engineers

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Deployed cross site calibrated physiologic monitoring systems for MRI at BWH, Children’s, BIDMC, Harvard FAS and MIT

Catalyst created a community of biomedical engineers w/ a shared focus on supporting C/T imaging


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MGH Biomedical Imaging Core Coming in July 2009!Coming in July 2009!Webform PCIR applicationWebform PCIR application

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Medical Imaging Informatics

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• Examples:

– Clinical:• Ruling out appendicitis based on CT scans. Are

there metrics that can be found by analyzing clinical data?

• Quantitative output from Freesurfer for Alzheimer disease

– Research:• Helping TIMC get easier access to PACS system

for clinical trials


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Secondary Use of Clinical Imaging Data (Integration with i2b2)





Desikan et al, Brain in press

Standard T1 MRI scan

AUC 0.95 (specificity 91%, sensitivity 90% to discriminate MCI from age matched controls


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• IT Catalyst infrastructure:– i2b2: scalable computational framework to help

translation of genomic findings. – BIRN: XNAT imaging informatics platform: large

collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.

– NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer.

XNATEnterprise

DataRepository

(CRC)

FileRepository

IdentityManagement

OntologyManagement

CorrelationAnalysis

De -Identification

Of dataNatural

LanguageProcessing

AnnotatingGenomicData #1

ProjectManagement

WorkflowFramework

AnnotatingGenomicData #2PACS PACS

i2b2 HIVE

Dr X Desktop Pediatric

rare disease

Dr YDesktop

Alzheimer

Dr ZDesktop

Chronic pain management Dr W

Desktop Quantitative

cancer biomarkers


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Educational Program

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• Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff

• Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc)

• Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms

• Dissemination: through national networks (CTSA, RSNA, IRAT, SNM)

National Effort in C/T Research

39 AHC/23 states

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• Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08

Source: http://www.ctsaweb.org/

Duke

Mayo Clinic

Cornell

J.Hopkins

UC Davis

Wash. U.

Northwestern

Emory U.

• 14 Imaging programs-(Dan Sullivan/RSNA)

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http://[email protected]

www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC

randy gollub, md,phd

Documents

site codirectorannick

site codirectorneil

site codirectorclare

site codirectorron kikinis

site codirectorwilliam

site codirectorsimon

site codirectorjeff

imaging consortium team