rafael v. davalos, ph.d. reston w p b … · rafael v. davalos, ph.d. l. preston wade professor,...

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RAFAEL V. DAVALOS, PH.D. L. PRESTON WADE PROFESSOR,BIOMEDICAL ENGINEERING AND MECHANICS VIRGINIA TECH –WAKE FOREST UNIVERSITY HOME ADDRESS: 1205 REDBUD ROAD,BLACKSBURG, VA 24060 CELL: 540-998-9197 E-MAIL: DAVALOS@VT.EDU EDUCATION Ph.D. University of California - Berkeley, CA Department of Mechanical Engineering - 2002 Major: Bioengineering Minors: Dynamics and BioMEMS Advisor: Boris Rubinsky Dissertation Title: Real-time imaging for molecular medicine through electrical impedance tomography of electroporation M.S. University of California - Berkeley, CA Department of Mechanical Engineering – 1995 Major: Design B.S. Cornell University - Ithaca, NY Mechanical and Aerospace Engineering - 1994 RESEARCH AND TEACHING INTERESTS Biotransport, design, cellular engineering microsystems, bioheat transfer, dielectrophoresis, medical device design for cancer detection and treatment, electroporation, microfluidic tissue mimics, bio- inspired microfluidics, scaffolds for tissue engineering, brain-on-a-chip. PROFESSIONAL APPOINTMENTS Virginia Tech – Wake Forest University - Blacksburg, VA Professor: School of Biomedical Engineering and Sciences, 15 – present Professor: Biomedical Engineering and Mechanics, 15 - present Associate Professor: School of Biomedical Engineering and Sciences, 11 - 15 Adjunct Appointment: Mechanical Engineering, 13 - present Adjunct Appointment: Wake Forest Institute of Regenerative Medicine, 08 - present Affiliate Appointment: Engineering Science and Mechanics at Virginia Tech, 08 - present Assistant Professor: School of Biomedical Engineering and Sciences, 06 - 11 Sandia National Laboratories - Livermore, CA Principal Member of Technical Staff: Microsystems and Advanced Concepts Engineering, 06 - 07 Senior Member of Technical Staff: Microsystems Design and Integration, 05 - 06 Senior Member of Technical Staff: National Security Engineering, 03 - 05 Senior Member of Technical Staff: Exploratory Systems Technology Division, 99 - 00 Member of Technical Staff: Advanced Weapons Systems Division, 95 - 99 LICENSING OF INVENTIONS Protea Biosciences (Morganstown, WV): Acquired rights to license microfluidics technology Angiodynamics (Queensbury, NY): FDA approved system, which has treated over 5500 cancer patients BC Genesis (Blacksburg, VA): Start-up company based on licensed bio-fabrication technology PhenoCHIP (Blacksburg, VA): Start-up company licensed rare cell sorting technology VoltMed (Blacksburg, VA): Start-up company licensed platform to treat brain cancer

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RAFAELV.DAVALOS,PH.D.L.PRESTONWADEPROFESSOR,BIOMEDICALENGINEERINGANDMECHANICSVIRGINIATECH–WAKEFORESTUNIVERSITYHOMEADDRESS:1205REDBUDROAD,BLACKSBURG,VA24060CELL:540-998-9197E-MAIL:[email protected]. UniversityofCalifornia-Berkeley,CA DepartmentofMechanicalEngineering-2002 Major:Bioengineering Minors:DynamicsandBioMEMSAdvisor:BorisRubinsky DissertationTitle:Real-timeimagingformolecularmedicinethroughelectricalimpedance

tomographyofelectroporationM.S. UniversityofCalifornia-Berkeley,CA DepartmentofMechanicalEngineering–1995 Major:DesignB.S. CornellUniversity-Ithaca,NY MechanicalandAerospaceEngineering-1994RESEARCHANDTEACHINGINTERESTSBiotransport,design,cellularengineeringmicrosystems,bioheattransfer,dielectrophoresis,medicaldevicedesignforcancerdetectionandtreatment,electroporation,microfluidictissuemimics,bio-inspiredmicrofluidics,scaffoldsfortissueengineering,brain-on-a-chip.

PROFESSIONALAPPOINTMENTSVirginiaTech–WakeForestUniversity-Blacksburg,VAProfessor:SchoolofBiomedicalEngineeringandSciences,15–presentProfessor:BiomedicalEngineeringandMechanics,15-presentAssociateProfessor:SchoolofBiomedicalEngineeringandSciences,11-15AdjunctAppointment:MechanicalEngineering,13-presentAdjunctAppointment:WakeForestInstituteofRegenerativeMedicine,08-presentAffiliateAppointment:EngineeringScienceandMechanicsatVirginiaTech,08-presentAssistantProfessor:SchoolofBiomedicalEngineeringandSciences,06-11SandiaNationalLaboratories-Livermore,CAPrincipalMemberofTechnicalStaff:MicrosystemsandAdvancedConceptsEngineering,06-07SeniorMemberofTechnicalStaff:MicrosystemsDesignandIntegration,05-06SeniorMemberofTechnicalStaff:NationalSecurityEngineering,03-05SeniorMemberofTechnicalStaff:ExploratorySystemsTechnologyDivision,99-00MemberofTechnicalStaff:AdvancedWeaponsSystemsDivision,95-99LICENSINGOFINVENTIONSProteaBiosciences(Morganstown,WV):AcquiredrightstolicensemicrofluidicstechnologyAngiodynamics(Queensbury,NY):FDAapprovedsystem,whichhastreatedover5500cancerpatientsBCGenesis(Blacksburg,VA):Start-upcompanybasedonlicensedbio-fabricationtechnologyPhenoCHIP(Blacksburg,VA):Start-upcompanylicensedrarecellsortingtechnologyVoltMed(Blacksburg,VA):Start-upcompanylicensedplatformtotreatbraincancer

COURSESTAUGHTBiomedicalMicrodevices:Creationandinstructionofgraduatecourse,07-presentQuantitativePhysiology:Co-instructionofcoregraduatecourseinbiomedicalengineering,07-presentTransportProcessesinBiologicalSystems:Undergraduatecourseinbiologicaltransport,10-presentSeniorDesignCourse:Mentorstudentsindesignofplatformfororganscaffolds,10-presentEngineeringMathematics:Createdcross-disciplinarycourseforfirstyeargraduatestudents,11-presentFundamentalsofCancer:CourseinTranslational,Biology,HealthandMedicineprogram,15–presentSELECTEDHONORSANDAWARDSDean’sAward:ExcellenceinResearch,16NamedProfessorship:L.PrestonWadeProfessorship,16-presentInnovatorAward:Roanoke-BlacksburgTechnologyCouncil(RBTC)TechNite,15ASMEFellow,TheAmericanSocietyofMechanicalEngineers,15InnovatorAward:InstituteofCriticalTechnologiesandAppliedSciences,14RichardSkalakAward:ASMEJournalofBiomechanicalEngineeringforBestPaper,14XCaliberCertificateofExcellence:Technology-EnrichedLearning,CenterofInnovation,VirginiaTech,13OutstandingDissertationAdvisoroftheYear:VirginiaTech,12WallaceH.CoulterFellow,WallaceH.CoulterFoundation,12CollegeofEngineeringFacultyFellow:CollegeofEngineering,VirginiaTech,11-14NSFCAREERAwardRecipient:NationalScienceFoundation,11UnrestrictedResearchGrant:Angiodynamics,09-10OutstandingNewAssistantProfessorAward:CollegeofEngineering,VirginiaTech,09NanoKnife:Oneof20institutionsawarded$395Kunit,08-presentEarlyCareerAward:WallaceH.CoulterFoundation,08-12Top7Inventionsof’07:IrreversibleElectroporation.NASATechBriefs,TheYearinTechnology,07SpecialIssueonIrreversibleElectroporation:TechnologyinCancerResearchandTreatment,07FeaturedonNPR’sPulseofthePlanet:IrreversibleElectroporationTherapy,07,12and13NationalAwardRecipient:HENAAC–Nation’sMostPromisingEngineerorScientist,06AppointedChair:SandiaNationalLaboratoriesDiversityDivisionCouncil,05-06DoctoralStudiesFellowship:SandiaNationalLaboratories,00–02SELECTEDINVITEDTALKSPlenarySpeaker:BioelectrochemistrySocietyAnnualMeeting,Lyon,France,17InvitedSpeaker:IEEEIMS,Honolulu,HI,17InvitedSpeaker:BioEM2016,Ghent,Belgium,16InvitedSpeaker:Int’lSymposiumonElectro&LiquidPhase-SeparationTechniques,Minneapolis,MN16InvitedSpeaker:FACCSSciX2016,Minneapolis,MN16PlenarySpeaker:1stWorldCongressonElectroporation,Portoroz,Slovenia,15InvitedSpeaker:SNO-SCIDOTJointConferenceonTherapeuticDeliverytotheCNS,SanAntonio,TX,15InvitedSpeaker:IEEEEMBS,CellularBioMEMSMiniSymposium,Chicago,IL14InvitedSpeaker:11thInternationalBioelectricsSymposium,Columbia,MO,14InvitedSpeaker:MicroscaleBioSeparations,Charlottesville,VA,13InvitedSpeaker:1stInt’lSymponBacterialNanocellulose,245thACSAnnMeeting,NewOrleans,LA,13InvitedSpeaker:GordonConference,Bioelectrochemistry.Nr.Lucca,Italy,12InvitedSpeaker:34thAnnualIEEEEMBSConference,SanDiego,CA,12InvitedSpeaker:Int’lScientificWorkshoponFundamentalsandAppliedBioelectrics,Norfolk,VA,12KeynoteSpeaker:Int’lSymposiumonElectro&LiquidPhase-SeparationTechniques,Baltimore,MD,12InvitedSpeaker:SHPE,ThermofluidsandBiomedicalOpticsSymposium.Anaheim,CA,11

InvitedSpeaker:38thFACSSConference.Reno,NV,11InvitedSpeaker:FourthAnnualBreastCancerSymposium.PeoriaIL,11InvitedSpeaker:IEEEEMBSElectricFieldsEffectsinTumorsWorkshop.Argentina,10InvitedSpeaker:7thInternationalBioelectricsSymposium.Norfolk,VA,10InvitedSpeaker:EngineeringPlatformsforExploringCellularandMolecularProcesses.ULouisville,10InvitedSpeaker:ThermalBiologyandTherapyWorkshop.UMinnesota,10InvitedSpeaker:SocietyforCNSInterstitialDeliveryofTherapeutics.ClevelandClinic,09InvitedSpeaker:36thFACSSConference.Louisville,KY,09PlenarySpeaker:45thAnnualMeetingoftheSocietyforCryobiology.CharlotteNC,08InvitedSpeaker:CommercializationofDrugDiscovery,DeliveryandDiagnostics.Cambridge,MA,05APPOINTMENTSANDACTIVITIESMember:TheAmericanElectrophoresisSociety,09-presentMember:BrainTumorCenterofExcellenceatWakeForestUniversity,09-presentMember:WakeForestUniversityComprehensiveCancerCenter,08-presentMember:BiomedicalEngineeringSociety,08-presentMember:BioelectrochemistrySociety(BES),03-presentMember:ASMEBiotransportDivision,02-presentVisitingResearchAssociate:CNRS,InstitutGustaveRoussy,France,01-02OUTREACHANDPROFESSIONALSERVICEInternationalOrganizingCommittee:2ndWorldCongressonElectroporation,Norfolk,Virginia,17StudySectionChair:NIHIMST-15SBIR/STTRCellandMolecularBiology,17-presentSessionChair:BioEM16,Micro-chambersforsinglecellelectromagneticexposureandanalysis,16AssociateEditor:IEEETransactionsonBiomedicalEngineering,15-presentGuestEditor:BiomedicalEngineeringOnline-SpecialIssue,15ScientificProgramCommittee:1stWorldCongressonElectroporation,Portoroz,Slovenia,15SessionChair:1stWorldCongressonElectroporation,Portoroz,Slovenia,15SpecialSessionCo-Chair:MBEC2014:Advancedtechfortreatingdeep-seatedtumorsusingECTandIRESessionChair:BioelectrochemistryGordonResearchConf,CellsandModelsUnderElectricFields,14SessionChair:BioelectrochemistryGordonResearchSeminar,CellsandModelsUnderElectricFields,14AssociateEditor:ASMEJournalofMedicalDevices,13-presentProgramChair:AmericanElectrophoresisSocietyAnnualMeeting,13InformationChair:ASMESummerBioengineeringConference,13EditorialBoard:JournalofElectrophoresis,11-presentSessionChair:BMES,NanotoMicrotechnologies:BioMEMSII,14BMES,ImplantableDevicesandImplantableElectronics,14BMES,NanotoMicrotechnologies:MicrotechnologiesforCancer,14BMES,TranslationBiomedicalEngr:TherapeuticandDiagnosticBiomedicalDevices,13ITP2012,Dielectrophoresis,12AIChE,Electroporation,ElectrophysiologyandCellElectrokinetics,11-13IEEEEngineeringinMedicineandBiologyConference,MagneticSensorsandSystems,12ASMESummerBioengineeringConference,ImaginginBiotransport,12ASMESummerBioengineeringConference,BiotransportinDeviceandDesign,10ASMESummerBioengineeringConference,ImprovementsinThermalTherapy,09ASMESummerBioengineeringConference,CharacterizationofThermalMedicalApplications,08ASMESummerBioengineeringConference,BiothermalTherapy,07ASMEHeatTransferConf,ExperimentalandComputationalMethodsinMedicineandBiology,05

ASMEIMECE,BioengineeringDivision,ThermalAspectsofMolecularSurgery,04SessionCo-Chair:ASMESummerBioengineeringConference,TargetedDeliveryandElectroporation,11AIChE,ElectrokineticBehaviorofMicroparticlesandNanoparticles,10AIChE,AdvancesinElectrokineticsandElectrophoresis-ParticlesandBiomolecules,09TrackChair:IEEEEMBC(Co-Chair:MKhine),Bioinstrumentation:Microfluidics,11-12IEEEEMBC(Co-chair:RCLee),ElectricFieldsattheCellandProteinScale,10IEEEEMBC(Co-chair:RCLee),ElectricFieldsattheCellandProteinScale,09Judge:ASMESummerBioengineeringConference,StudentPosterCompetition,10ASMESummerBioengineeringConference,StudentPodiumCompetition,08-09Peerreviewer:Nature-ScientificReports,AppliedPhysicsLetters,JBCOnline,JournalofTissueEngineering,IEEETransactionsonBiomedicalEngineering,ASMEJournalofBiomechanicalEngineering,BiomedicalMicrodevices,LabonaChip,Bioelectrochemistry,AnnalsofBiomedicalEngineering,IEEEEMBC,ASMESBC,JournalofThermalBiology,TechnologyinCancerResearchandTreatment,IEEETransactionsonPlasmaScience,ChemicalReviews,AnalyticalChemistry,JournalofMembraneBiology,IEEETransactionsonDielectricsandElectricalInsulation,IEEETransactionsonInstrumentationandMeasurement,Biomicrofluidics,AnalyticalandBioanalyticalChemistry,PLoSONE,Electrophoresis,ASMEJournalofNanotechnologyinEngineeringandMedicine,BiomedicalEngineeringOnline,Nanomedicine,CancerResearch,Analyst,BiomaterialsReviewpanel:NationalScienceFoundation,07-presentCariploFoundationScientificCommittee,11-presentNationalInstituteofHealth,12-presentAirForceOfficeofScientificResearch,12EngineeringandPhysicalSciencesResearchCounciloftheUnitedKingdom,12 INTERNALSERVICEANDDIVERSITYINITIATIVESDirector:ICTASCenterforEngineeredHealth,16-presentMember:StakeholderCommitteeonInnovationandEntrepreneurship,16-presentChair:SearchCommitteeforAssistant/AssociateProfessor,16-17Member:AdvanceVT/InclusiveVTDiversityCommittee,16-presentMember:VTCRI5-yearReviewCommittee,16Member:SearchCommitteeforCollegeofEngineeringDean,16-presentMember:SearchCommitteeforVMCVMAssociateDeanofResearchandGraduateStudies,16Member:IntellectualPropertyCommittee,15-presentMember:BeyondBoundariesCommittee,15-presentMember:SearchCommitteeforExecutiveVicePresidentandProvost,15Member:SearchCommitteeforAssociateDeanofVeterinarySchool,15Member:SearchCommitteeforWFAssistantProfessor,15Chair:SearchCommitteeforVTAssistantProfessorPositionatVirginiaTech,12SteeringCommittee:CenterforDrugDiscovery,Development,andDelivery(CD4),12-presentMember:SearchCommitteeforVTAssistantProfessorPositionatVirginiaTech,11Member:SearchCommitteeforWFAssistantProfessorPositionatVirginiaTech,11 Instructor:InterdisciplinaryTrainingatACCInterdisciplinaryForumforDiscoveryinLifeSciences,10KeynoteSpeaker:Kids’TechUniversity:Whycan'thumanswalkonwaterandclimbwallswiththeirfingertipslikespiders,April,10Speaker:WorkshopsforC-TECH2andNASAHigh-SchoolSummerPrograms,10PanelMember:VirginiaTechGEMGRADLab,10Member:SearchCommitteeforSBESDepartmentHeadatVirginiaTech,09Director:CollegeofEngineeringDiversitySummerProgram,07-14

Director:NSF/NIBIBBioengineeringandBioinformaticsSummerInstitute,07-12Chair:ICTASThemeAreaonCellularEngineeringMicrosystems(CEMS),07–presentCo-Director:ICTASMulti-scaleBio-EngineeredDevices&Systems(M-BEDS),07-presentRecruiter:RepresentVirginiaTechatSHPECareerFairs,07-presentCoordinator:SBESgraduatestudentweekendandotherrecruitmentefforts,07-presentMember:VirginiaTechCollegeofEngineeringDiversityCommittee,07-presentEXTERNALGRANTS(>$16MTotal,$14.7MVT,>$4.5MPIShare)DevelopmentofINSPIREforBrainCancerTreatmentPI:RVDavalos,Source:VirginiaBiosciencesHealthResearchCorporation(VBHRC)(2016-2017,$380K)

RoleofExtracellularSpaceasaModulatoroftheCardiacGapJunction-ConductionVelocityRelationshipPI:SPoelzing(Co-I:RVDavalos,RGourdie,JSmyth)Source:NIH(2017-2021,$2.1M)R01HL102298

High-FrequencyIrreversibleElectroporationforGBMPI:RVDavalos,SVerbridge(Co-I:JRobertson,JRossmeisl)Source:NIH(2017-22,$1.76M)R01CA213423

RepurposetheIrreversibleElectroporationSystemforOptimalImmuneModulationEfficacyPI:RVDavalos(Co-PI:RCMartin),Source:CuresWithinReach(2017-2018,$50K)

DevelopmentofnextgenerationIREtreatpancreaticcancerPI:DIannitti(Co-PI:RVDavalos),Source:PanCAN(2016-2018,$300K)16-65-IANN

STTRPhaseI:AnEndoscopic-BasedINSPIREPlatformforTreatingandMonitoringUnresectablePancreaticCancerVoltMedPI:MBSano,VTPIDavalos,Source:NSF(2014,$225K,VT$68K)IIP-1346343

MinimallyInvasiveSurgicalPlatformforH-FIREandChemotherapyTreatmentVoltMedPI:PAGarcia(VTPI:Davalos)Source:CITCRCF(2015-16,$50K,VT$20K)STTR15-002-LS

STTRMatch:INSPIRETherapy:Real-timetreatmentandmonitoringofPancreaticCancerVoltMedPI:RVDavalos,Source:CITCRCF(2014,$50K)STTR14S-003-LS

HighFrequencyIrreversibleElectroporationforPancreaticCancerPI:CClark(Co-PI:RVDavalos),Source:GolfersAgainstCancer(2015-16,$40K)

PhenoCHIP:Phenotype-basedCellHierarchyandIsolationPlatformPI:RVDavalos,Source:VirginiaBiosciencesHealthResearchCorporation(VBHRC)(2014-2015,$270K)

R21:TargetedElectricFieldTherapyforMalignantInfiltrativeGliomaMPI:RVDavalos,SVerbridge,SourceNIH(2014-2017,$386K)1R21CA192041-01

SBIRPhaseI:InnovativeBiofabricationof3DNano-BiocompositesforRepairofOsteochondralDefectsBCGenesisPI:PGatenholm,VTPI:RVDavalos,Source:NIH(2013,$150K,$25KVT)R43AG044153-01A1

R21:IsolationofTumorInitiatingCells(TICs)usingContactlessDielectrophoresisPI:RVDavalos(Co-PI:SCramer),Source:NIH(2013-2015,$368K)5R21CA173092-01

UseofbioceramicnanoscaffoldstoenhanceirreversibleelectroporationforinsitutissuedestructionPI:IMcKillop(Co-PI:RVDavalos),Source:CarolinaMedicalCenter(2014-2015,$47K,$7.6KVT)

HighFrequencyIrreversibleElectroporationforLungCancerandotherEndoscopicAblationApplicationsPI:RVDavalos,Source:CITCRCF(2013-2014,$100K)MF13-034-LS

UseofElectricFieldsfortheIsolationofTumorInitiatingCellsandotherRareCellsPI:RVDavalos,Source:CITCRCF(2013-2014,$100K)MF13-037-LS

NSFRET:BiomechanicsfromMoleculartoOrganismalScalesPI:DDudek(Co-PI:JSocha,SP:RVDavalos),Source:NSF(2014-2016,$500K)RET1301037

I-Corps:TranslationofHighFrequencyIrreversibleElectroporationforHumanClinicalApplications,PI:RVDavalos,Source:NSF(2012-2013,$50K)IIP1265105

EFRI-REM:ComplexMicrosystemNetworksInspiredbyInternalInsectPhysiologyPI:JSocha(Co-PI:RVDavalos,IPuri),Source:NSF(2013-2014,$114K)RET-0938047

EFRI-REM:ComplexMicrosystemNetworksInspiredbyInternalInsectPhysiologyPI:JSocha(Co-PI:RVDavalos,IPuri),Source:NSF(2012-2013,$100K)RET-0938047

CAREER:AnexperimentalandnumericalinvestigationofthebiophysicalprocessesofpulsedelectricfieldinducedirreversibleelectroporationforGlioblastomaMultiformePI:RVDavalosSource:NSF(2011-17,$452K)CBET-1055913

IGERT:MultiScaleTransportinEnvironmentalandPhysiologicalSystems(MultiSTEPS)PI:MAStremler(Co-PI:RVDavalos,JKuhn,SRoss,PVlachos)Source:NSF(2010-14,$3M)DGE-0966125

EFRI-BSBAComplexMicrosystemNetworksInspiredbyInternalInsectPhysiologyPI:JSocha(Co-PI:RVDavalos,RDeVita,JHarrison,AStaples),Source:NSF(2010-13,$2M)EEC-0938047

QuantificationofBlood-Brain-BarrierDisruptionAchievedbyIntracranialN-TIREforanOptimizedCombinatorialTherapyAgainstGBMPI:TLEllis(Co-PI:RVDavalos),Source:GolfersAgainstCancer(2010-11,$28K)

TaskOrder1:CalibrationCurvesforCassiniOvalLesionEstimatorPI:RVDavalos,Source:Angiodynamics(2010,$20K)

TaskOrder2:RegressionAnalysistoFitNumericalModelstoExperimentalDataPI:RVDavalos,Source:Angiodynamics(2010,$30K)

TaskOrder3:Three-DimensionalIrreversibleElectroporationModelingandFieldCharacterizationPI:RVDavalos,Source:Angiodynamics(2010,$30K)

TaskOrder4:FEAModelingofAblationVariablesPI:RVDavalos,Source:Angiodynamics(2012,$104K)

TaskOrder5:HydrogelModelingofIREPI:RVDavalos,Source:Angiodynamics(2013,$40K)

TaskOrder6:BrainPaperPI:RVDavalos,Source:Angiodynamics(2013,$38K)

TaskOrder9:BipolarprobemodelingPI:RVDavalos,Source:Angiodynamics(2013-2014,$32K)

TaskOrder10:CharacterizationofLesionVolumesusingexvivosamplesPI:RVDavalos,Source:Angiodynamics(2015,$12K)

TaskOrder11:ModelingofFieldDistributionsinTissuePI:RVDavalos,Source:Angiodynamics(2015,$10K)

TaskOrder12:ExperimentalevaluationusingperfusedorganmodelsPI:RVDavalos,Source:Angiodynamics(2015-2016,$65K)

TaskOrder13:AdvancedExperimentalAblationProtocolsPI:RVDavalos,Source:Angiodynamics(2016-2017,$65K)

SBIR:CustomizableMeniscusImplantPreparedbyDielectrophoreticBiofabrication-PhaseIandPhaseIIBCGenesisPI:PGatenholm,VTPI:RVDavalos,Source:NSF(2009-12,$1,141K,$180KVT)IIP-1026421

CombinatorialBrainCancerTherapythroughIrreversibleElectroporationandCarbonNanotubesPI:RVDavalos(Co-PI:MNRylander),Source:NSFCBET(2009-11,$300K)CBET-0933335

UnrestrictedResearchGrant:ModelingofIrreversibleElectroporationPI:RVDavalos,Source:Angiodynamics(2009-10,$15K)

UnrestrictedResearchGrantPI:RVDavalos,Source:ProteaBiosciences(2011-12,$10K)

UnrestrictedResearchGrantPI:RVDavalos,Source:ProteaBiosciences(2014-15,$25K)

IrreversibleElectroporationDevicestoTreatCancer-PhaseIandPhaseIIPI:RVDavalos(Co-PI:TLEllis),Source:CoulterFoundation-EarlyCareerAward(2008-12,$500K)

IsolationandEnrichmentofTumorStemCellsusingInsulator-BasedDielectrophoresisPI:SCramer(Co-PI:RVDavalos),Source:GolfersAgainstCancer(2008-10,$35K)

QuantitativeEvaluationofMicro-ElectroporationPI:RVDavalos,Source:JeffressMemorialTrust(2008,$20K)

NSF-NIBIBBBSI:SummerInstituteforQuantitativeandIntegrativeBioengineeringPI:RVDavalos(InitialPI:EScott,Co-PI:RCLaubenbacher),Source:NSF(2006-10,$649K)EEC-0609225INTERNALSUPPORTMicrofluidicModelofCancerPI:RVDavalos(Co-PI:CFinkelstein),Source:FralinBiotechnologyCenter(2010,$10K)

DielectrophoreticMicroweavingPI:RVDavalos(Co-PI:PGatenholm),Source:ICTAS(2009-11,$99K)

CancerTherapythroughIrreversibleElectroporationEnhancedwithCarbonNanotubesPI:RVDavalos,Source:ComprehensiveCancerCenter-WakeForestUniversity(2008-09,$25K)

ImplantableMicro-OncologistsPI:RVDavalos(Co-PI:MAgah,IPuri,GWang,PGatenholm),Source:ICTAS(2007-09,$104K)

PEER-REVIEWEDJOURNALARTICLES(cited>4800timeswithh-index36)1. IGoswami,SCoutermarsh-Ott,RGMorrison,ICAllen,RVDavalos,SVerbridge,LRBickford.

Irreversibleelectroporationinhibitspro-cancerinflammatorysignalingintriplenegativebreastcancercells,Bioelectrochemistry,vol113,pp42-50,2017.(IF3.903)

2. IASiddiqui,ELLatouche,MRDeWitt,JHSwet,RCKirks,EHBaker,DAIannitti,DVrochides,RV

Davalos,IHMcKillop.Inductionofrapid,reproduciblehepaticablationsusingnext-generation,highfrequencyirreversibleelectroporation(H-FIRE)invivo.HPB,vol18(9),pp726-734,2016.(IF2.918)

3. TMurovec,DCSweeney,ELatouche,RVDavalos,CBrosseau.Modelingoftransmembrane

potentialinrealisticmulticellularstructuresbeforeelectroporation,BiophysicalJournal,vol111,pp2286-2295,2016.(IF3.972)(cover)

4. MBonakdar,EWWasson,YWLee,RVDavalos.Electroporationofbrainendothelialcellsonchiptowardpermeabilizingtheblood-brain-barrier,BiophysicalJournal,vol110,pp505-512,2016.(IF3.972)(cover)

5. SPBhonsle,MBonakdar,RE.Neal,CAardema,JLRobertson,JHowarth,HKavnoudias,KRThomson,

SNGoldberg,RVDavalos.Characterizationofirreversibleelectroporationablationwithavalidatedperfusedorganmodel.JournalofVascularandInterventionalRadiology,vol27,pp1913-1926,2016.(IF2.570)

6. DCSweeney,MReberšek,JDermol,LRems,DMiklavčič,RVDavalos.Quantificationofcell

membranepermeabilityinducedbymonopolarandhigh-frequencybipolarburstsofelectricalpulses.BBA-Biomembranes,1858(11),pp2689-2698,2016.(IF3.687)

7. JCemazar,TADouglas,EMSchmelz,RVDavalos.Enhancedcontactlessdielectrophoresis

enrichmentandisolationplatformviacell-scalemicrostructures.Biomicrofluidics,vol10pp014109:1-14,2016.2016Editor’sPick(IF3.357)

8. SAGeorge,MBonakdar,MZeitz,RVDavalos,JSmyth,SPoelzing.Extracellularsodiumdependence

oftheconductionvelocityrelationship:evidenceonephapticselfattenuation.AmericanJournalofPhysiology-HeartandCirculatoryPhysiology,vol310(9),ppH1129-H1139,2016.(IF3.838)

9. JWIvey,ELLatouche,MBSano,JHRossmeisl,RVDavalos,SSVerbridge.Targetedcellularablation

basedonthemorphologyofmalignantcells,NatureScientificReports,vol5:17157,2015.(IF5.078)10. MBSano,CBArena,KRBittleman,MRDeWitt,PAGarcia,HJCho,CCSzot,DSaul,JMCissell,J

Robertson,YWLee,RVDavalos.Burstsofbipolarmicrosecondpulsesinhibittumorgrowth,NatureScientificReports,vol5:14999,2015.(IF5.078)

11. JHRossmeisl,PAGarcia,TEPancotto,JLRobertson,NHenao-Guerrero,RENeal,TLEllis,RVDavalos.

SafetyandfeasibilityofthenanoKnifesystemforirreversibleelectroporationablativetreatmentofcaninespontaneousintracranialgliomas.JNeurosurgery,2015vol123(4),pp1008-1025.(IF3.227)

12. SPBhonsle,CBArena,DCSweeney,RVDavalos.Mitigationofimpedancechangesdueto

electroporationtherapyusingburstsofhigh-frequencybipolarpulses.BiomedicalEngineeringOnline,vol14(S3),2015.(IF1.430)

13. MBonakdar,ELatouche,RMahajan,RVDavalos.Thefeasibilityofasmartsurgicalprobefor

verificationofIREtreatmentsusingElectricalImpedanceSpectroscopy(EIS),IEEETransactionsonBiomedicalEngineering,vol62(11),pp2674-2684,2015.(IF2.347)

14. ABaah-Dwomoh,ARolong,PGatenholm,RVDavalos.Thefeasibilityofusingirreversible

electroporationtointroduceporesinbacterialcellulosescaffoldsfortissueengineering.AppliedMicrobiologyandBiotechnology,vol99(11),pp4785-4794,2015.(IF3.811)

15. RENeal,PAGarcia,HKavnoudias,FRosenfeldt,CAMclean,EVVictoria,JBergman,RVDavalos,KR

Thomson.Invivoirreversibleelectroporationkidneyablation:Experimentallycorrelatednumericalmodels.IEEETransactionsonBiomedicalEngineering,vol62(2),pp561-569,2015.(IF2.233)

16. KRColacino,CBArena,SDong,MRoman,RVDavalos,YWLee.Folateconjugatedcellulosenanocrystalspotentiateirreversibleelectroporation-inducedcytotoxicityfortheselectivetreatmentofcancercells,TechnologyinCancerResearchandTreatment,vol14(6),pp757-766,2015.(IF1.943)

17. CBArena,PAGarcia,MBSano,JDOlson,TRogers-Cotrone,JHRossmeisl,RVDavalos.Focalblood-

brain-barrierdisruptionwithhigh-frequencypulsedelectricfields.Technology,vol9(8),pp1-8,2014.(IFN/A)

18. PAGarcia,RVDavalos,DMiklavcic.Anumericalinvestigationoftheelectricandthermalcellkill

distributionsinelectroporation-basedtherapiesintissue.PLoSONE,vol9(8),ppe103083:1-12,2014.(IF4.537)

19. MBSano,CBArena,MRDeWitt,DSaur,RVDavalos.In-vitrobipolarnano-andmicrosecondelectro

pulseburstsforirreversibleelectroporationtherapies.Bioelectrochemistry,vol100,pp69-79,2014.(IF3.774)

20. RCGallo-Villanueva,MBSano,BHLapizco-Encinas,RVDavalos.Jouleheatingeffectsonparticle

immobilizationininsulator-baseddielectrophoreticdevices.Electrophoresis,vol35(2-3),pp352-361,2014.(IF3.261)

21. RENeal,JLMillar,HKavnoudias,PRoyce,FRosenfeldt,APham,RSmith,RVDavalos,KRThomson.

Invivocharacterizationandnumericalsimulationofprostatepropertiesfornon-thermalirreversibleelectroporationablation.TheProstate,vol74(5),pp458-468,2014.(IF3.843)

22. RENeal,JHRossmeisl,VD'Alfonso,JLRobertson,PAGarcia,SElankumaran,RVDavalos.Invitroand

numericalsupportforcombinatorialirreversibleelectroporationandelectrochemotherapygliomatreatment,AnnalsofBiomedicalEngineering,vol42(3)pp475-487,2014.(IF2.575)

23. ASalmanzadeh,ESSavage,PCRoberts,EMSchmelz,RVDavalos.Sphingolipidmetabolitesmodulate

cellsdielectriccharacteristicsinamouseovariancancerprogressionmodel.IntegrativeBiology(cover),vol5(6),pp843–852,2013.(IF4.509)

24. RENeal,JHRossmeisl,JLRobertson,CBArena,EMDavis,RNSingh,JStallings,RVDavalos.Improved

localandsystemicanti-tumorefficacyforirreversibleelectroporationinimmunocompetentversusimmunodeficientmice,PLoSONE,vol8(5),e64559:1-10,2013.(IF4.537)

25. CBArena,RLMahajan,MNRylander,RVDavalos.Anexperimentalandnumericalinvestigationof

phasechangeelectrodesfortherapeuticirreversibleelectroporation,ASMEJournalofBiomechanicalEngineering,vol135(11),pp111009:1-9,2013.Editor’sChoicePaper,RichardSkalakAward(IF1.519)

26. MBSano,RCGallo-Villaneuva,BHLapizco-EncinasRVDavalos.Simultaneouselectrokineticflowand

dielectrophoretictrappingusingperpendicularstaticanddynamicelectricfields.MicrofluidicsandNanofluidics,vol15(5),pp599-609,2013.(IF3.503)

27. SYXiao,JJCharonko,XPFu,ASalmanzadeh,RVDavalos,PPVlachos,CVFinkielstein,DGSCapelluto.Structure,Sulfatide-bindingProperties,andInhibitionofplateletaggregationbyadisabled-2-derivedpeptide,JournalofBiologicalChemistry,vol287(45),pp36791-37702,2013.(IF5.117)

28. ASalmanzadeh,MBSano,RCGallo-Villanueva,PCRoberts,EMSchmelz,RVDavalos.Investigating

dielectricpropertiesofdifferentstagesofsyngeneicmurineovariancancercells.Biomicrofluidics,vol7(1),pp0118094:1-12,2013.(IF3.896)FeaturedarticleinspecialissueinBiomicrofluidicsonCancer

29. RENealII,RLSmith,HKavnoudias,FRosenfeldt,ROu,CAMclean,RVDavalos,KRThomson.The

effectsofmetallicimplantsonelectroporationtherapies:Feasibilityofirreversibleelectroporationforbrachytherapysalvage,CardioVascularandInterventionalRadiology,vol36(6)pp1638-1645,2013.(IF2.09)

30. JHRossmeisl,PAGarcia,JLRoberston,TLEllis,RVDavalos,Pathologyofnon-thermalirreversible

electroporation(N-TIRE)-inducedablationofthecaninebrain,JournalofVeterinaryScience,vol14(4)pp433-440,2013.(IF0.93)

31. CBArena,RLMahajan,MNRylander,RVDavalos.Towardsthedevelopmentoflatentheatstorage

electrodesforelectroporation-basedtherapies,AppliedPhysicsLetters,vol101(8),pp83902:1-4,2012.(IF3.844)

32. CBArena,CBSzot,PAGarcia,MNRylander,RVDavalos.Athree-dimensionalinvitrotumor

platformformodelingtherapeuticirreversibleelectroporation,BiophysicalJournal,vol103(9),pp2033-2042,2012.(IF3.653)

33. ASalmanzadeh,LRomero,HShafiee,RCGallo-Villanueva,MAStremler,SDCramer,RVDavalos.

Isolationofprostatetumorinitiatingcells(TICs)throughtheirdielectrophoreticsignature.LabonaChip,vol12,pp182-189,2012.(IF6.342)

34. ASalmanzadeh,HKittur,MBSano,PCRoberts,EMSchmelz,RVDavalos.Dielectrophoretic

differentiationofmouseovariansurfaceepithelialcells,macrophagesandfibroblastsusingcontactlessdielectrophoresis(cDEP).Biomicrofluidics,vol6,pp024014:1-13,2012.(IF3.896)FeaturedinVirtualJournalofBiologicalPhysicsResearch

35. PAGarcia,JHRossmeisl,JLRobertson,JDOlson,AJJohnson,TLEllis,RVDavalos.7.0-Tmagneticresonanceimagingcharacterizationofacuteblood-brain-barrierdisruptionachievedwithintracranialirreversibleelectroporation.PLoSONE,vol7(11),ppe50482:1-7,2012(IF4.537)

36. RENealII,PAGarcia,JLRobertson,RVDavalos.Experimentalcharacterizationandnumerical

modelingoftissueelectricalconductivityduringpulsedelectricfieldsforirreversibleelectroporationtreatmentplanning.IEEETransactionsonBiomedicalEngineering,vol59(4),pp1077-1085,2012.(IF2.154)

37. MBSano,ASalmanzadeh,RVDavalos.Multilayercontactlessdielectrophoresis:Theoretical

considerations.Electrophoresis(InvitedpaperforSpecialIssueonMiniaturiation),vol33(13),pp1938-1946,2012.(IF3.569)

38. RENealII,JHRossmeislJr,PAGarcia,OLantz,NHenao-Guerrero,RVDavalos.Successfultreatmentofalargesoft-tissuesarcomawithirreversibleelectroporation.JournalofClinicalOncology,vol29(13),pp372-377,2011.(IF17.793)

39. MBSano,EHenslee,ESchmelz,RVDavalos.Contactlessdielectrophoreticspectroscopy:Examinationofthedielectricpropertiesofcellsfoundinblood.Electrophoresis,SpecialIssueonMiniaturization,vol32(22),pp3164-3171,2011.(IF3.569)

40. MBSano,JLCaldwell,RVDavalos.Modelinganddevelopmentofalowfrequencycontactless

dielectrophoresis(cDEP)platformtosortcancercellsfromdilutewholebloodsamples.BiosensorsandBioelectronics,vol30(1),pp13-20,2011.(IF5.429)

41. ASalmanzadeh-Dozdabi,HShafiee,RVDavalos,MAStremler.Mixingenhancementinmicrofluidic

devicesutilizingcontactlessdielectrophoresis(cDEP).Electrophoresis(cover),vol32(8),pp2569-2578,2011.(IF3.569)

42. EAHenslee,MBSano,ADRojas,RVDavalos.Selectiveconcentrationofhumancancercellsusing

contactlessdielectrophoresis(cDEP).Electrophoresis,vol32(8),pp2523-2529,2011.(IF3.569)43. CBArena,MBSano,JHRossmeisl,JLCaldwell,PAGarcia,MNRylander,RVDavalos.High-frequency

irreversibleelectroporation(H-FIRE)fornon-thermalablationwithoutmusclecontraction.BiomedicalEngineeringOnline,vol10(10),2011.HighlyAccessedDistinction.(IF1.639)

44. RCGallo,VHPerez-Gonzalez,RVDavalos,BHLapizco-Encinas.Separationofmixturesofparticlesin

amultipartmicrodeviceemployinginsulator-baseddielectrophoresis.Electrophoresis,vol32(8),pp2456-2465,2011.(IF3.569)

45. CBArena,MBSano,MNRylander,RVDavalos.Theoreticalconsiderationsoftissueelectroporation

withhighfrequencybipolarpulses.IEEETransactionsonBiomedicalEngineering,vol58(5),pp1474-1482,2011.(IF2.154)

46. PAGarcia,TPancotto,JHRossmeislJr,NHenao-Guerrero,NRGustafson,GBDaniel,JLRobertson,TL

Ellis,RVDavalos.Non-thermalirreversibleelectroporation(N-TIRE)andadjuvantfractionatedradiotherapeuticmultimodaltherapyforintracranialmalignantgliomainacaninepatient.TechnologyinCancerResearchandTreatment,vol10(1),pp73-83,2011.(IF2.032)

47. TLEllis,PAGarcia,JHRossmeislJr,NHGuerrero,JRobertson,RVDavalos.Non-thermalirreversibleelectroporation(N-TIRE)forintracranialsurgicalapplications.JournalofNeurosurgery,vol114(3),pp681-688,2011.(IF2.594)

48. JDWelsh,JJCharonko,ASalmanzadeh,KEDrahos,HShafiee,MAStremler,RVDavalos,DGS

Capelluto,PPVlachos,CVFinkielstein.Disabled-2modulateshomotypicandheterotypicplateletinteractionsbybindingtosulfatides.BritishJournalofHematology,vol154(1),pp122-133,2011.(IF4.597)

49. PAGarcia,JHRossmeisl,RENealII,TLEllis,RVDavalos.Aparametricstudydelineatingirreversible

electroporationfromthermaldamagebasedonaminimallyinvasiveintracranialprocedure.BiomedicalEngineeringOnline,vol10:34,2011.HighlyAccessedDistinction.(IF1.639)

50. MBSano,RENealII,PAGarcia,DGerber,JRobertson,RVDavalos.Towardsthecreationoforgan

constructsusingirreversibleelectroporationandactivemechanicalperfusion.BiomedicalEngineeringOnline,vol9(83),2010.HighlyAccessed.(IF1.639)

51. HShafiee,MBSano,EHenslee,JLCaldwell,RVDavalos.Selectiveisolationoflive-deadcellsusing

contactlessdielectrophoresis(cDEP).LabonaChip(cover),vol10,pp438-445,2010.(IF6.342)52. RENealII,RSingh,HHatcher,STorti,RVDavalos.Treatmentofbreastcancerthroughthe

applicationofirreversibleelectroporationusinganovelminimallyinvasivesingleneedleelectrode.BreastCancerResearchandTreatment,vol123,pp295-301,2010.(IF4.696)

53. MBSano,ARojas,PGatenholm,RVDavalos.Dielectrophoreticmicroweaving:Biofabricationof

alignedbacterialcellulosenanofibrils.AnnalsofBiomedicalEngineering,vol38(8),pp2475-2484,2010.(IF2.409)

54. PAGarcia,JHRossmeisl,RENealII,TLEllis,JOlson,NHenao-Guerrero,JRobertson,RVDavalos.

Intracranialnon-thermalirreversibleelectroporation:Invivoanalysis,JournalofMembraneBiology,vol236(1),pp127-136,2010.(IF2.189)

55. HShafiee,JLCaldwell,RVDavalos.Amicrofluidicsystemforbiologicalparticleenrichmentutilizing

contactlessdielectrophoresis(cDEP)(invitedpaper).JournaloftheAssociationforLaboratoryAutomation(JALA),vol15(3),pp224-232,2010.(IF1.420)

56. RENealII,RVDavalos.Thefeasibilityofirreversibleelectroporationforthetreatmentofbreastcancerandotherheterogeneoussystems.AnnalsofBiomedicalEngineering,vol37(12),pp2615-2625,2009.(IF2.409)

57. HShafiee,JLCaldwell,MBSano,RVDavalos.Contactlessdielectrophoresisforparticlemanipulationon-chip.BiomedicalMicrodevices,vol11(5),pp997-1006,2009.(IF3.323)

58. HShafiee,PAGarcia,RVDavalos.Delineationofirreversibleelectroporation(IRE)fromJouleheatingeffectsusingthearrheniusequation.ASMEJournalofBiomechanicalEngineering,vol131(7)pp074509:1-074509:5,2009.(IF2.657)

59. PSabounchi,AMMorales,PPonce,LPLee,BASimmons,RVDavalos.Sampleconcentrationandimpedancedetectiononamicrofluidicpolymerchip.BiomedicalMicrodevices,vol10(5),pp661-670,2008.(IF3.323)

60. RVDavalos,GJMcGraw,TIWallow,AMMorales,KLKrafcik,GJFiechtner,YFintschenko,EBCummings,BASimmons.Performanceimpactofdynamicsurfacecoatingsonpolymericinsulator-baseddielectrophoreticparticleseparators.AnalyticalandBioanalyticalChemistry(cover),vol390(3),pp847-855,2008.(IF3.480)

61. CDJames,NReuel,ESLee,RVDavalos,SSMani,ACarroll-Portillo,RRebeil,AMartino,CAApblett.Impedimetricandopticalinterrogationofsinglecellsinamicrofluidicdeviceforreal-timeviabilityandchemicalresponseassessment.BiosensorsandBioelectronics,vol23pp845–851,2008.(IF5.429)

62. RVDavalos,BRubinsky.Temperatureconsiderationsduringirreversibleelectroporation.ASME

InternationalJournalofHeatandMassTransfer,vol51(23-24),pp5617-5622,2008.(IF1.947)

63. BAl-Sakere,CBernat,FAndré,EConnault,POpolon,RVDavalos,BRubinsky,LMMir.Tumorablationwithirreversibleelectroporation.PLoSOne,vol2(11),pp1-8,2007.(IF4.351)

64. DRobinson,ESLee,ZIqbal,JLRognlien,RVDavalos.Reinforcedvesicleswithstandrigorsof

microfluidicelectroporation.SensorsandActuators:BChemical,vol125,pp337-342,2007.(IF3.083)

65. JFEdd,RVDavalos.Mathematicalmodelingofirreversibleelectroporationfortreatmentplanning.TechnologyinCancerResearchandTreatment,vol6(4),pp275-286,2007.(IF2.032)

66. BAl-Sakere,CBernat,FAndré,EConnault,POpolon,RVDavalos,LMMir.Astudyoftheimmunologicalresponsetotumorablationwithirreversibleelectroporation.TechnologyinCancerResearchandTreatment,vol6(4),pp301-306,2007.(IF2.032)

67. ESLee,DRobinson,JLRognlien,CKHarnett,BASimmons,CRBEllis,RVDavalos.Robustgiantlipid

vesiclesandmicro-electroporationtechnologyforcontrollablemanipulationofpicolitervolumeson-chip.Bioelectrochemistry,vol69,pp117-125,2006.(IF2.652)

68. JFEdd,LHorowitz,RVDavalos,LMMir,BRubinsky.In-vivoresultsofanewfocalablationtechnique:Irreversibleelectroporation.IEEETransactionsonBiomedicalEngineering,vol53(5),pp1409-1415,2006.(IF2.154)

69. BHLapizco-Encinas,RVDavalos,BASimmons,EBCummings,YFintschenko.Aninsulator-based(electrodeless)dielectrophoreticconcentratorformicrobesinwater.JournalofMicrobiologicalMethods,vol62,pp317-326,2005.(IF2.427)

70. RVDavalos,LMMir,BRubinsky.Tissueablationwithirreversibleelectroporation.AnnalsofBiomedicalEngineering,vol33(2),pp223-231,2005.(IF2.409)

71. RVDavalos,DMOtten,LMMir,BRubinsky.Electricalimpedancetomographyforimagingtissueelectroporation.IEEETransactionsonBiomedicalEngineering,vol51(5),pp761-767,2004.(IF2.154)

72. RVDavalos,BRubinsky.Electricalimpedancetomographyofcellviabilityintissuewithapplicationtocryosurgery.ASMEJournalofBiomechanicalEngineering,vol126(2),pp305-309,2004.(IF2.657)

73. RVDavalos,BRubinsky,LMMir.Theoreticalanalysisofthethermaleffectsduringinvivotissueelectroporation.Bioelectrochemistry,vol61(1-2),pp99-107,2003.(IF3.520)

74. RVDavalos,DMOtten,BRubinsky.Afeasibilitystudyforelectricalimpedancetomographyasameanstomonitortissueelectroporationformolecularmedicine.IEEETransactionsonBiomedicalEngineering,vol49(4),pp400-403,2002.(IF2.154)

75. RVDavalos,YHuang,BRubinsky.Electroporation:Bio-electrochemicalmasstransferatthenanoscale.NanoscaleandMicroscaleThermophysicalEngineering,vol4(3),pp147-159,2000.(IF1.900)

76. BRubinsky,RVDavalos.Theuseofevolutionary-geneticanalogyinnumericalanalysis.

CommunicationsinNumericalMethodsinEngineering,vol14(2),pp151-160,1998.(IF0.595)

77. RVDavalos,BRubinsky.Anevolutionary-geneticapproachtoheattransferanalysis.ASMEJournalofHeatTransfer,TransactionsoftheASME,vol118(3),pp528-532,1996.(IF0.959)

BOOKCHAPTERSANDREVIEWARTICLES1. JIvey,MBonakdar,AKanitkar,RVDavalos,SSVerbridge.Improvingcancertherapiesbytargeting

physicalandchemicalhallmarksofthetumormicroenvironment–minireview.CancerLetters,vol380(1),pp330-339,2016.(IF5.992)

2. JCemazar,AGhosh,RVDavalos.ElectricalManipulationandSortingofCells.Chapter3In:MicrotechnologyforCellManipulationandSorting,pp57-92.EditedbyWLee,PTseng,DDiCarlo.SpringerInternationalPublishing,Switzerland,2017.

3. KYano,LRems,TKotnik,DMiklavcic,JCWeaver,KCSmith,RSSon,TRGowrishankar,PTVernier,ZA

Levine,MPRols,JTeissie,LMMir,AGPakhomov,PNick,WFrey,DADean,KMorotomi-Yano,RENealII,SBhonsle,RVDavalos,SJBeebe.Ch4:BiologicalResponses.In:Bioelectrics,pp.155-274,EditedbyHAkiyama,RHeller,Springer,Japan,2017.

4. RHeller,JTeissie,MPRols,JGehl,GSersa,LMMir,RENealII,SBhonsle,RVDavalos,SBeebe,BHargrave,RNuccitelli,CJiang,MCemazar,YTamzali,NTozon.Ch5:MedicalApplications.In:Bioelectrics,pp.275-388,EditedbyHAkiyama,RHeller,Springer,Japan,2017.

5. EMWasson,TADouglas,RVDavalos.Mechanicalandelectricalprinciplesforseparationofrare

cells.ChapterIn:MicrofluidicMethodsforBiology,Ch13,pp253-294,EditedbyCLuandSSVerbridge,SpringerInternationalPublishing,Switzerland,2016.

6. PAGarcia,JHRossmeisl,Jr,TLEllis,RVDavalos.Nonthermalirrversibleelectroporationasafocal

ablationtreatmentforbraincancer.Chapter15In:TumorsoftheCentralNervousSystem,vol12,pp171-182,EditedbyMAHayat,Springer,London,2015.

7. CJiang,RVDavalos,JCBischof.AReviewofbasictoclinicalstudiesofirreversibleelectroporation

Therapy,IEEETransactionsonBiomedicalEngineering,vol62(1),pp4-20,2014.(IF2.233)(cover)8. PAGarcia,RENealII,RVDavalos.Non-thermalirreversibleelectroporationfortissueablation.

Electroporationinlaboratoryandclinicalinvestigations,NOVASciencePublishers,Inc.NewYork,USA,2012(cover).

9. ASalmanzadeh,RVDavalos.ElectrokineticsandRare-CellDetection.Chapter3In:Microfluidicsin

DetectionScience:Lab-on-a-chipTechnologies,pp61-83,EditedbyFHLabeedandHOFatoyinbo,RoyalSocietyofChemistry,UnitedKingdom,2015.

10. PGatenholm,JBerry,ARojas,MBSano,RVDavalos,KJohnson,LO’Rourke(cover).Bacterial

nanocellulosebiomaterialswithcontrolledarchitecturefortissueengineeringscaffoldsandcustomizableimplants,Ch10In:PerspectivesinNanotology,BacterialNanoCellulose:ASophisticatedMultifunctionalMaterial.pp197-216,EditedbyMGama,PGatenholm,DKlemm,CRCPress,BocaRaton,FL,2012.

11. MBSano,RVDavalos.Isolationofrarecellsusingmicrofluidics.Ch12In:MEMSforBiomedical

Applications.WoodheadPublishingLimited,WoodheadPublishingSeriesinBiomaterials,Number43,EditedbySBhansaliandAVasudev,Cambridge,2012.

12. CBArena,RENealII,RVDavalos.ElectroporationTherapy,PhysicalMedicineandRehabilitation:PrinciplesandApplicationsAndersBrahme,editor-in-chief.In:ComprehensiveBiomedicalPhysics,vol10,pp269-287,Amsterdam:Elsevier,2014.

13. MVOrtiz,RVDavalos.Cellelectroporationmechanismsandpreclinicalfoundationforfocaltherapy.

Ch23inImagingandFocalTherapyofEarlyProstateCancer,CurrentClinicalUrology.EditorThomasPolascik,pp309-329,Springer,NewYork,2013

14. RVDavalos,PAGarcia,JFEdd.Thermalaspectsofirreversibleelectroporation.IrreversibleElectroporation,EditorBRubinsky,Springer-Verlag,BerlinHeidelberg,Germany,pp123-154,2010.

15. GJMcGraw,MKanouff,JTCeremuga,RVDavalos,BHLapizco-Encinas,PMela,RShediac,JDBrazzle,

JTHachman,GJFiechtner,EBCummings,YFintschenko,BASimmons.Acomparisonofinsulator-baseddielectrophoreticdevicesforthemonitoringandseparationofwater-bornepathogensasafunctionofmicrolithographicfabricationtechnique.ACSSymposiumSeries2007,980(AntiterrorismandHomelandDefense),133-157,15plates.CODEN:ACSMC8ISSN:0097-6156.AN2008:346219CAPLUS,2008.

16. BASimmons,GJMcGraw,RVDavalos,GJFiechtner,YFintschenko,EBCummings.Developmentof

polymericdevicesasdielectrophoreticseparatorsandconcentrators.MRSBulletin(cover),vol31,pp120-1242006.(IF1.879)

PEER-REVIEWEDCONFERENCEPROCEEDINGS1. SPBhonsle,MBonakdar,SNGoldberg,RVDavalos,RENealII.Perfusedorganmodeldevelopment

andevaluationforirreversibleelectroporationinvestigations.11thEuropeanConferenceonAntennasandPropagation(EuCAP2017),Paris,France,Mar19-242017.

2. SPBhonsle,CBArena,RVDavalos.Afeasibilitystudytomitigatetissue-tumorheterogeneityusing

highfrequencybipolarelectroporationpulses.6thEuropeanConferenceoftheInternationalFederationforMedicalandBiologicalEngineering(IFMBE)Proceedings(MBEC2014),vol45,pp565-568,Dubrovnik,Croatia,Sept7-11,2014.

3. ELLatouche,RVDavalos,RCMartinII.ModelingofIrreversibleElectroporationTreatmentsforthe

OptimizationofPancreaticCancerTherapies.6thEuropeanConferenceoftheInternationalFederationforMedicalandBiologicalEngineering(IFMBE)Proceedings(MBEC2014),vol45,pp801-804,Dubrovnik,Croatia,Sept7-11,2014.

4. ARolong,KProkop,RVDavalos.Impactofnanoparticlesonirreversibleelectroporationtreatments:

canthelesionbeenhancedbeyondIREmargin?6thEuropeanConferenceoftheInternationalFederationforMedicalandBiologicalEngineering(IFMBE)Proceedings(MBEC2014),vol45,pp793-796,Dubrovnik,Croatia,Sept7-11,2014.

5. JRossmeisl,PGarcia,JRobertson,RVDavalos.Irreversibleelectroporationforthetreatmentofbraintumors:Pre-clinicalresultsinacaninemodelofspontaneousglioma.6thEuropeanConferenceoftheInternationalFederationforMedicalandBiologicalEngineering(IFMBE)Proceedings(MBEC2014),vol45,pp809-812,Dubrovnik,Croatia,Sept7-11,2014.

6. RENealII,PAGarcia,HKavnoudias,FRosenfeldt,CAMcLean,VEarl,JBergman,RVDavalos,KR

Thomson.Simulationofinvivoirreversibleelectroporationrenalablations.6thEuropeanConferenceoftheInternationalFederationforMedicalandBiologicalEngineering(IFMBE)Proceedings(MBEC2014),vol45,pp813-816,Dubrovnik,Croatia,Sept7-11,2014.

7. PAGarcia,RVDavalos,DMiklavcic.Anumericalevaluationofthecellkilldistributionsdueto

thermaldamageinelectrochemotherapy.6thEuropeanConferenceoftheInternationalFederationforMedicalandBiologicalEngineering(IFMBE)Proceedings(MBEC2014),vol45,pp817-820,Dubrovnik,Croatia,Sept7-11,2014.

8. JCemazar,LMAnders,SDCramer,RVDavalos(invited).Contactlessdielectrophoresisdevicefor

highthroughputseparationoftumorinitiatingcells.IEEEEngineeringinMedicineandBiologyConference(EMBC`14),Chicago,IL,Aug26-30,2014.

9. PAGarcia,CBArena,RENealII,SNGoldberg,EBen-David,RVDavalos.Adaptingthecassinicurveto

approximateinvivoirreversibleelectroporationablationsinporcineliver.SBC2013-14817,ASMESummerBioengineeringConference,SunRiver,OR,June26-29,2013.

10. RENealII,HKavnoudias,FRosenfeldt,ROu,JMarron,RDavalos,KThompson.Invivovalidationof

irreversibleelectroporationelectricfieldthresholdforprostatetissue.SBC2013-14425,ASMESummerBioengineeringConference,SunRiver,OR,June26-29,2013.

11. ASalmanzadeh,MBSano,HShafiee,MStremler,RVDavalos.Isolationofrarecancercellsfrom

bloodcellsusingdielectrophoresis,IEEEEngineeringinMedicineandBiologyConference(EMBC`12),SanDiego,CA,Aug28-Sep1,pp490-493,2012.

12. PAGarcia,CArena,RVDavalos(invited).Towardsapredictivemodelofelectroporation-based

therapiesusingpre-pulseelectricalmeasurements,IEEEEngineeringinMedicineandBiologyConference(EMBC`12),SanDiego,CA,Aug28-Sep1,pp2575-2578,2012.

13. CBArena,RLMahajan,MNRylander,RVDavalos.Phasechangeelectrodesforreducingjoule

heatingduringirreversibleelectroporation.SBC2012-80825,ASMESummerBioengineeringConference,Fajardo,PuertoRico,June20-23,2012.1stPlacePhDStudentPaperCompetition

14. ASalmanzadeh,HKittur,MSano,MStremler,CRoberts,ESchmelz,RVDavalos.Investigatingdielectrophoreticsignaturesofmouseovariansurfaceepithelialcells,macrophagesandfibroblasts.SBC2012-80872,ASMESummerBioengineeringConference,Fajardo,PuertoRico,June20-23,2012.

15. PAGarcia,JPearce,RVDavalos.Acomparisonbetweenthepulsedanddutycycleapproachesusedtocapturethethermalresponseoftissueduringelectroporation-basedtherapies.SBC2012-80574,ASMESummerBioengineeringConference,Fajardo,PuertoRico,June20-23,2012

16. MBSano,CBArena,PAGarcia,RVDavalos.Irreversibleelectroporationusingthevasculatureofanorganasfluidelectrodes.SBC2012-80870,ASMESummerBioengineeringConference,Fajardo,PuertoRico,June20-23,2012.

17. RENealII,PAGarcia,JRobertson,RVDavalos.Experimentalcharacterizationofintrapulsetissue

conductivitychangesforelectroporation.IEEEEngineeringinMedicineandBiologyConference(EMBC`11),Boston,MA,Aug30-Sep3,pp5581-5584,2011.

18. MBSano,JLCaldwell,RVDavalos.Alowcostsolutionforthefabricationofdielectrophoreticmicrofluidicdevicesandembeddedelectrodes.IEEEEngineeringinMedicineandBiologyConference(EMBC`11),Boston,MA,Aug30-Sep3,pp8384-8387,2011.

19. PAGarcia, JHRossmeisl,JRobertson,RVDavalos(invited).Electricalconductivitychangesduring

irreversibleelectroporationtreatmentofbraincancer.IEEEEngineeringinMedicineandBiologyConference(EMBC`11),Boston,MA,Aug30-Sep3,pp739-742,2011.

20. CBArena,MBSano,MRylander,RVDavalos.Highfrequencyelectroporationforcancertherapy.

ASMESummerBioengineeringConference,Farmington,PA,Jun22-25,2011.21. PAGarcia,JHRossmeisl,TLEllis,RVDavalos.Amethodtodelineateirreversibleelectroporation

fromthermaldamagevalidatedexvivowithreal-timetemperature.ASMESummerBioengineeringConference,Farmington,PA,Jun22-25,2011.

22. CSSzot,CArena,PAGarcia,RVDavalos,JFreeman,NRylander.Anovelinvitromodelfor

irreversibleelectroporationbasedcancertherapiesandtreatmentplanning.ASMESummerBioengineeringConference,Farmington,PA,Jun22-25,2011.

23. ARojas,ESchmelz,RDavalos.Separationanalysisofbreastcancerprogressionusingcontactlessdielectrophoresis.ASMESummerBioengineeringConference,Farmington,PA,Jun22-25,2011.

24. ASalmanzadeh,HShafiee,MStremler,RDavalos.Mixingenhancementinmicrofluidicdevicesusingcontactlessdielectrophoresis.ASMESummerBioengineeringConference,Farmington,PA,Jun22-25,2011.

25. ASalmanzahdeh,HShafiee,MSano,MStremler,RVDavalos.Enrichmentofcancercellsusinga

highthroughputcontactlessdielectrophoretic(cDEP)microfluidicdevice.ASMESummerBioengineeringConference,Farmington,PA,Jun22-25,2011

26. PAGarcia,RENealII,JHRossmeislJr,RVDavalos.Non-thermalirreversibleelectroporationfordeepintracranialdisorders.IEEEEngineeringinMedicineandBiologyConference(EMBC`10),BuenosAires,Argentina,Aug31-Sep4,pp2743-2746,2010.

27. RENealII,PAGarcia,JHRossmeislJr,RVDavalos.Astudyusingirreversibleelectroporationtotreatlarge,irregulartumorsinacaninepatient.IEEEEngineeringinMedicineandBiologyConference(EMBC`10),BuenosAires,Argentina,Aug31-Sep4,pp2747-2750,2010.

28. EHenslee,ESchmelz,RVDavalos.Isolationofhumanbreastcancercellsbymetastaticstageusingcontactlessdielectrophoresis.ASMESummerBioengineeringConference,Naples,FL,Jun16-19,pp22-23,2010.

29. MBSano,RVDavalos.Continuousseparationofparticlesusingcontactlessdielectrophoresis.ASME

SummerBioengineeringConference,Naples,FL,Jun16-19,pp30-31,2010.30. PAGarcia,JHRossmeislJr,JLRobertson,TLEllis,RVDavalos.Pilotstudyofirreversible

electroporationforintracranialsurgery.IEEEEngineeringinMedicineandBiologyConference(EMBC’09),Minneapolis,MN,Sep2-6,pp1:6513-6516,2009.NorthAmericanFinalist

31. CBArena,MNRylander,RVDavalos.Theoreticalstudyforthetreatmentofpancreaticcancerusing

electricpulses.IEEEEngineeringinMedicineandBiologyConference(EMBC’09),Minneapolis,MN,Sep2-6,pp1:5997-6000,2009.

32. PAGarcia,SElankumaran,RVDavalos.Pilotstudyofirreversibleelectroporationtotreatbrain

cancer.ASMESummerBioengineeringConference,LakeTahoe,CA,Jun17-21,pp32-33,2009.33. CBArena,MNRylander,RVDavalos.Pilotstudyontheenhancementofirreversibleelectroporation

(IRE)withcarbonnanotubes(CNT).ASMESummerBioengineeringConference,LakeTahoe,CA,Jun17-21,pp18-19,2009.

34. RENealII,RSingh,STorti,RVDavalos.Feasibilitystudyforapplyingirreversibleelectroporationto

thetreatmentofbreastcancer.ASMESummerBioengineeringConference,LakeTahoe,CA,Jun17-21,pp16-17,2009.

35. HShafiee,MBSano,JCaldwell,RVDavalos.Analternativetechniquefordielectrophoretic(DEP)cell

manipulation:ContactlessDEP.ASMESummerBioengineeringConference,LakeTahoe,CA,Jun17-21,pp54-55,2009.

36. MBSano,RVDavalos,PGatenholm.DielectrophoreticMicroweaving:Biofabricationofaligned

bacterialnanocelluloseforregenerativemedicine.ASMESummerBioengineeringConference,LakeTahoe,CA,Jun17-21,pp56-57,2009.

37. PSabounchi,AMMorales,BASimmons,RVDavalos.Integratedmicrofluidicsample

preconcentratorandimpedancedetectionplatformforpathogenmonitoring.RoyalSocietyofChemicalSpecialPublications,12thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,SanDiego,CA,Oct12-16,pp1051-1053,2008.

38. PAGarcia,JLRobertson,JRossmeisl,RVDavalos.Irreversibleelectroporation(IRE)totreatbrain

cancer.ASMESummerBioengineeringConference,MarcoIsland,FL,Jun25-29,pp101-102,2008.39. HShafiee,RVDavalos.Anautonomouscelltypeselectiveirreversibleelectroporationmicrosystem

usinginsulator-baseddielectrophoresis(iDEP).ASMESummerBioengineeringConference,MarcoIsland,FL,Jun25-29,pp591-592,2008.

40. PPonce,BASimmons,MKhine,RVDavalos.Abioparticledetectorusingintegratedinsulator-based

dielectrophoresisandbioimpedancemeasurements.RoyalSocietyofChemicalSpecialPublications,

10thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Tokyo,Japan,Nov5-9,pp987-989,2006.

41. ESLee,SSBachelor,ZQIqbal,LPLee,RVDavalos.Viabilityafteron-chipsingle-cellmicro-

electroporationforthestudyofmacrophagesignalingpathways.RoyalSocietyofChemicalSpecialPublications,10thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Tokyo,Japan,Nov5-9,pp1345-1347,2006.

42. PSabounchi,AMMorales,BASimmons,RVDavalos.Autonomouslabelfreeopticaldetectionof

sporestrappinginaninsulator-baseddielectrophoreticconcentrator.RoyalSocietyofChemicalSpecialPublications,10thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Tokyo,Japan,Nov5-9,pp470-472,2006.

43. JCStachowiak,EEShugard,PFCaton,BPMosier,RFRenzi,RVDavalos,GJMcGraw,BASimmons,VA

Vandernoot,BAHaroldsen.Automatedsamplepreparationsystemforrapidbiologicalthreatdetection.ASMEBioengineeringDivision,ASMEInternationalMechanicalEngineeringCongressandExposition,Orlando,FL,Nov5-11,vol57,pp29-30,2005.

44. GJMcGraw,RVDavalos,BMMittal,SMFerko,MCHunter,JDBrazzle,YFintschenko,EBCummings,

BASimmons.Scalabilityofinsulator-baseddielectrophoresis(iDEP)anditsutilizationasahigh-throughputparticleconcentrator.RoyalSocietyofChemicalSpecialPublications,9thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Boston,MA,Oct9-13,pp705-708,2005.

45. GJMcGraw,KLKrafcik,TIWallow,MHunter,AMorales,RVDavalos,YFintschenko,EBCummings,

BASimmons.Effectofsurfactantsonelectroosmoticflowinapolymericinsulator-baseddielectrophoretic(iDEP)device.RoyalSocietyofChemicalSpecialPublications,9thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Boston,MA,Oct9-13,pp748-751,2005.

46. MKhine,ALau,CIZanetti,JSeo,ESLee,RVDavalos,LPLee.Alow-voltagesinglecell

electroporationarrayforintracellularcompounddelivery.RoyalSocietyofChemicalSpecialPublications,9thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Boston,MA,Oct9-13,pp856-858,2005.

47. ESLee,DRobinson,JLRognlien,CKHarnett,BASimmons,CRBEllis,PMDentinger,CMMunoz,RV

Davalos.Preparationandelectricallymonitoredmanipulationofgiantlipidvesiclesforimprovedmasstransporton-chip.RoyalSocietyofChemicalSpecialPublications,9thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Boston,MA,Oct9-13,pp445-448,2005.

48. ESLee,CMMunoz,BASimmons,CREllis,RVDavalos.Feasibilitystudyontheuseoftemperature-

dependentliposomesforvariableconcentrationprofilesindrugdeliveryapplications.ASMEHeatTransferDivision,ASMEInternationalMechanicalEngineeringCongressandExposition,Anahiem,CA,Nov13-19,vol375(1),pp763-766,2004.

49. RVDavalos,BHLapizco-Encinas,GJFiechtner,AKSingh,BASimmons,YFintschenko,EBCummings.

Aperformancecomparisonofpost-andridge-baseddielectrophoreticparticlesorters.Royal

SocietyofChemicalSpecialPublications,8thInternationalConferenceonMiniaturizedSystemsforChemistryandLifeSciences,Malmo,Sweden,Sep26-30,no296,pp650-652,2004.

50. RVDavalos,DMOtten,LMMir,BRubinsky.Afeasibilitystudyforimagingtissueelectroporation

withelectricalimpedancetomography.ASMEBioengineeringDivision,ASMEInternationalMechanicalEngineeringCongressandExposition,NewOrleans,LA,Nov17-22,vol54,pp153-154,2002.

CONFERENCEPROCEEDINGS1. PAGarcia,RENeal,MBSano,JLRobertson,RVDavalos(invited).Anexperimentalinvestigationof

temperaturechangesduringelectroporation.XXXURSIGeneralAssemblyandScientificSymposium,Istanbul,Turkey,Aug13-20,2011.

2. HShafiee,MBSano,JLCaldwell,RVDavalos.Anewstrategyforsampleconcentrationand

enrichment:ContactlessDielectrophoresis.AIChEAnnualMeeting,Nashville,TN,Nov8-13,pp240g,2009.

3. AMMorales,BASimmons,TIWallow,KJCampbell,SSMani,BMittal,RWCrocker,EBCummings,RVDavalos,LADomeier,MCHunter,KLKrafcik,GJMcGraw,BPMosier,SMSickafoose.Injectionmoldedmicrofluidicdevicesforbiologicalsampleseparationanddetection(invitedpaper).SPIEProceedings:MOEMS-MEMS2006-MicromachiningandMicrofabricationProcessTechnologyXI,SanJose,CA,Jan21-26,vol6109,pp610901:1-610901:11,2006.

4. RGGuerra,RVDavalos,PAGarcia,BRubinsky,MSBerger.Aheattransfermodeltocharacterizethefocalcoolingnecessarytosuppressspontaneousepileptiformactivity(invitedpaper).SPIEProceedings:PW05BBiomedicalOptics-ThermalTreatmentofTissue:EnergyDeliveryandAssessmentVI,SanJose,CA,Jan25-27,vol5698(23),pp240-246,2005.

5. GJMcGraw,RVDavalos,JDBrazzle,JTHachman,MCHunter,JMChames,GJFiechtner,EBCummings,YFintschenko,BASimmons.Polymericinsulator-baseddielectrophoresis(iDEP)forthemonitoringofwater-bornepathogens.SPIEProceedings:MOEMS-MEMS2005-MicromachiningandMicrofabricationProcessTechnologyX,SanJose,CA,Jan25-27,vol5715(6),pp59-68,2005.

6. RDavalos,BRubinsky.Theuseofconceptsfromgeneticsandevolutiontosolveproblemsofheattransfer.TheSymposiumonThermalScienceandEngineeringinHonorofChancellorChang-LinTien,RBuckiusEd,UniversityofIllinoisatUrbana-Champaign,Berkeley,CA,Nov10-12,pp541-546,1995.

ABSTRACTS1. MBonakdar,TJO’Brien,ELatouche,RVDavalos.Thedevelopmentofanintelligentsurgicalprobe

forreal-timemonitoringofelectroporation-basedtreatments.IEEEEMBSMicroandNano(MNMC2016),Waikola,HI,Dec12-16,2016.

2. TJO’Brien,PAGarcia,RVDavalos(invited).Irreversibleelectroporationforthetreatmentofbrain

cancer.IEEE2017InternationalMicrowaveSymposium,Honolulu,HI,Jun4-9,2017.

3. RVDavalos(invited),TADouglas,JCemazar,EMSchmelz.Contactlessdielectrophoresisfortheseparationofcancercellsatdifferentstagesofprogression.SciX2016,Minneapolis,MN,Sep18-23,2016.

4. RVDavalos(invited),TADouglas,JCemazar.Contactlessdielectrophoreticenrichmentoftumor

initiatingcellswithenhancedviabilityviacell-scalemicrostructures.SciX2016,Minneapolis,MN,Sep18-23,2016.

5. MBonakdar,ELatouche,RDavalos.Monitoringlesiondevelopmentduringirreversible

electroporationtreatmentusingelectricalimpedancespectroscopy,BiophysicalSocietyAnnualMeeting,LosAngeles,CA,Feb27-Mar2,2016.

6. SVerbridge(invited),JIvey,ELatouche,AKanitkar,MSano,ZSheng,JRossmeisl,RDavalos.Toward

targetingthephysicalhallmarksoftumorswithpulsedelectricfieldablationtherapy.BMESConference,Minneapolis,MN,Oct5-8,2016.

7. SBhonsle,ARolong,ASafaai-Jazi,CClark,RDavalos.Characterizationoftheelectricalpropertiesof

surgicallyresectedhumanhealthyandmalignantpancreatictissueinresponsetoirreversibleelectroporationfortreatmentofpancreaticcancer.BMESConference,Minneapolis,MN,Oct5-8,2016.

8. DSweeney,TDouglas,RDavalos.Unifyingcellularbioelectromagneticphenomena:

Dielectrophoresisandelectroporation.BMESConference,Minneapolis,MN,Oct5-8,2016.

9. TDouglas,JCemazar,ESchmelz,RDavalos.Contactlessdielectrophoresisfortumorsubpopulationseparationandenrichment.DieletrophoresisConference2016,MIT,Cambridge,MA,July13-15,2016.HerbertAPohlStudentPresentationAward

10. MBonakdar,EWasson,RVDavalos(invited).Usingamicrofluidicplatformasaminiaturizedmodel

oftheblood-brainbarriertostudymolecularuptakeduetopulsedelectricfields.BioEM2016,Ghent,Belgium,Jun5-10,2016.

11. ELLatouche(podiumaward),MBonakdar,RVDavalos.Smartsurgicalprobeforreal-time

monitoringofelectroporation-basedtreatments.BMES/FDAFrontiersinMedicalDevicesConferencescheduledforCollegePark,MD,May23-25,2016.

12. ABaah-Dwomoh,ARolong,PGatenholm,RVDavalos.Usingelectricfieldstoinduceporesin

bacterialcellulosescaffolds.SocietyforBiomaterialsAnnualMeeting,Charlotte,NC,April15-18,2015.

13. MBonakdar,EWasson,RVDavalos.Usingamicrofluidicplatformasaminiaturizedmodelofthe

blood-brainbarriertostudymolecularuptakeduetopulsedelectricfields.TheASME20154thGlobalCongressonNanoEngineeringforMedicineandBiology,Minneapolis,MN,April19-22,2015.

14. EWasson,MBonakdar,RVDavalos.AMicrofluidicDevicetostudytightjunctiondisruptioninthe

blood-brainbarrierusingpulsedelectricfields.TheASME20154thGlobalCongressonNanoEngineeringforMedicineandBiology,Minneapolis,MN,April19-22,2015

15. DSweeney,ELatouche,PRobberts,ESchmelz,RDavalos.Interdigitatedelectrodetotreatmicro-metastasesbyhigh-frequencyirreversibleelectroporation.BMESConference,SanAntonio,TX,Oct22-25,2014.

16. ARolong,KJProkop,PAGarcia,CBArena,RVDavalos.Irreversibleelectroporation:Prostateand

pancreaticcancercelldeaththresholdcharacterization.BMESAnnualMeeting,SanAntonio,TX,Oct22-25,2014.

17. JCemazar,LMAnders,SDCramer,RVDavalos.Highthroughputmicrofluidicseparationoftumor

initiatingcells(TICs)usingcontactlessdielectrophoresis.AIChEAnnualMeeting,Atlanta,GA,Nov16-21,2014.

18. CBArena,SPBhonsle,MBSano,RVDavalos(invitedspeaker).ClinicalImplicationsofNanosecond-

to-MicrosecondPulseBurstsforIrreversibleElectroporation.11thInternationalBioelectricsSymposium,Columbia,MO,October13-16,2014.

19. ASalmanzadeh,ESavage,PCRoberts,EMSchmelz,RDavalos.StudyingtheeffectsofSphingolipid

Metabolitesoncells’dielectrophoreticpropertiesusingcontactlessdielectrophoresis.AIChEAnnualMeeting,SanFrancisco,CANov3-8,2013.

20. MBSano,RVDavalos,Electroporationofcellsonchipusinghighfrequencyelectricfieldswithout

electrode-samplecontact.AIChEAnnualMeeting,SanFrancisco,CANov3-8,2013.21. MBonakdar,PGarcia,RDavalos.Characterizationofthepermeabilityofthebrainendotheliumdue

toelectroporationusingadynamicmicroengineeredmodel.AIChEAnnualMeeting,SanFrancisco,CANov3-8,2013.

22. PAGarcia,CBArena,JHRossmieslJr,RVDavalos.BiophysicalEffectsofPulsedElectricFieldsinthe

Brain.BMESAnnualMeeting,Seattle,WA,Sep25-28,2013.23. ASalmanzadeh,ESElvington,MBonakdar,PCRoberts,EMSchmelz,RVDavalos.Sphingolipid

metabolitesaffectdielectrophoreticsignatureofsyngeneicmurineovariancancercells.BMESAnnualMeeting,Seattle,WA,Sep25-28,2013.

24. MBonakdar,PAGarcia,RVDavalos.Blood-BrainBarrieronchip,Drugdeliveryenhancementby

electroporation.BMESAnnualMeeting,Seattle,WA,Sep25-28,2013.25. LMReese,PGarcia,RDavalos,PShen,GMishra,CWilliams,LBickford.Additivemanufactureof

minimally-invasivemedicaldevicesforpancreaticcancertreatment.BMESAnnualMeeting,Seattle,WA,Sep25-28,2013.

26. MBSano,CBArena,PAGarcia,JMCissell,JLRobertson,RVDavalos.Clinicalinvestigationofhigh

frequencyirreversibleelectroporationforskincancers.BMESAnnualMeeting,Seattle,WA,Sep25-28,2013.

27. PKyle,LAnders,JCemazar,CRoberts,ESchmelz,RDavalos.Theuseofelectrokineticphenomena

tocharacterizemalignantcells.BMESAnnualMeeting,Seattle,WA,Sep25-28,2013.

28. ASalmanzadeh,LRomero,SDCramer,RVDavalos(invitedspeaker).Enrichmentofcancerstemcellpopulationsbasedontheirdielectrophoreticcharacteristics.MSB2013,29thInternationalSymposiumonMicroScaleBioseparations,Charlottesville,VA,Mar10-14,2013.

29. ARolong,PGatenholm,KRodriguez,RVDavalos(Invitedspeaker).Electricalmanipulationof

bacteriatocontrolnanocellulosearchitectureforbiomedicalapplications,CELL:DivisionofCelluloseandRenewableMaterials-1stInternationalSymposiumonBacterialNanocellulose,245thACSAnnualMeeting,NewOrleans,LA,Apr7-11,2013.

30. PAGarcia,RVDavalos(invited).Clinicalprogressintheuseofirreversibleelectroporationforcancer

therapy.BioEM2013,Jun10-14,Thessaloniki,Greece,2013.31. ASalmanzadeh,ESavage(speaker),PCRoberts,EMSchmelz,RVDavalos(invited).Effectsofnon-

toxicxphingolipidmetabolitesonovariancancercells’dielectrophoreticcharacteristicsusingamicrofluidicplatform.AdvancesinMicrofluidicsandNanofluidics2013conference(SpecialSessiononDielectrophoresis),UniversityofNotreDame,IN,May24-26,2013

32. ASalmanzadeh,LRomero,SCramer,RVDavalos(Keynotespeaker).IsolationofCancerStemCells

(CSCs)basedontheirdielectrophoreticsignature.19thinternationalSymposiumonElectro-andLiquidPhase-separationTechniques(ITP2012),Baltimore,MD,USA,Sep30–Oct3,2012.

33. MBSano,MRDeWitt,CBArena,RVDavalos.Irreversibleelectroporationusingburstsofsub-

microsecondpulses.BMESAnnualMeeting,Atlanta,GA,Oct24-27,2012.34. HJCho,JAviles,CBArena,SDong,MRoman,RVDavalos,YWLee.Effectsofpulsedelectricfieldson

brainmicrovascularendothelialcellmonolayers.BMESAnnualMeeting,Atlanta,GA,Oct24-27,2012.

35. CBArena,CSSzot,PAGarcia,MNRylander,RVDavalos.Developmentoftissueengineeredtumors

fortreatmentplanninginelectroporation-basedtherapies.BMESAnnualMeeting,Atlanta,GA,Oct24-27,2012.

36. KRColacino,ACallo,CArena,SDong,MRoman,RDavalos,YLee.Synergisticallyenhanced

cytotoxiceffectoncancercellsbyirreversibleelectroporationandtargetedcellulosenanocrystals.BMESAnnualMeeting,Atlanta,GA,Oct24-27,2012.

37. ASalmanzadeh,MBonakdar,MBSano,LRomero,MAStremler,SDCramer,RVDavalos.

InvestigatingtheDielectrophoreticpropertiesofhumanprimaryprostatecancercells.BMESAnnualMeeting,Atlanta,GA,Oct24-27,2012.

38. PAGarcia,CBArena,CSSzot,RVDavalos.Electricfieldmodelingina3Dtissueengineeredtumor

treatedwithirreversibleelectroporation.BMESAnnualMeeting,Atlanta,GA,Oct24-27,2012.39. RVDavalos(invitedspeaker).Recentadvancesintheuseofirreversibleelectroporationforthe

treatmentofbraincancer.GordonResearchConferenceonBioelectrochemisty,Lucca,Italy,July1-6,2012.

40. RGallo,MBSano,RVDavalos,BHLapizco-Encinas.JouleheatingeffectsonthedielectrophoreticforceforiDEPfevices.AIChE2012AnnualMeeting,Oct28-Nov2,2012Pittsburg,PA

41. ASalmanzadeh,MBonakdar,MBSano,LRomero,RVDavalos,SDCramer.Investigatingthe

electricalpropertiesofprostatecancercelllinesusingcontactlessdielectrophoresis.AIChE2012AnnualMeeting,Oct28-Nov2,2012Pittsburg,PA(PosterAward)

42. ASalmanzadeh,ESavage,MBSano,MAStremler,PCRoberts,EMSchmelz,RVDavalos.

Dielectrophoresisforcharacterizingelectricalpropertiesofmouseovariansurfaceepithelial(MOSE)cells.AIChE2012AnnualMeeting,Oct28-Nov2,2012Pittsburg,PA

43. ESavage,MBSano,ASalmanzadeh,EMSchmelz,RVDavalos.Multi-layercontactless

dielectrophoresisusingthinpolyimidefilms,AIChE2012AnnualMeeting,Oct28-Nov2,2012Pittsburg,PA.

44. MBSano,RVDavalos.Investigationofthethermalandelectricalimpactofelectricfieldson

mammaliancellsmanipulatedusingcontactlessdielectrophoresis.AIChE2012AnnualMeeting,Oct28-Nov2,2012Pittsburg,PA

45. ASalmanzadeh,HPendar,JJSocha,MAStremler,RVDavalos.Studyingflowcontrolmechanismsin

aninsectrespiratorysystem.BMESAnnualMeeting,Hartford,CT,Oct12-15,2011.

46. PAGarcia,RENealII,CBArena,RVDavalos.Dynamicconductivitychangesduetoirreversibleelectroporationfortreatmentplanning.BMESAnnualMeeting,Hartford,CT,Oct12-15,2011.

47. RENeal,PAGarcia,CBArena,JRobertson,RVDavalos.Experimentaldeterminationof

electroporationconductivitychangeforcancertreatmentplanning.BMESAnnualMeeting,Hartford,CT,Oct12-15,2011.

48. CBArena,MBSano,MNRylander,JHRossmeislJr,RVDavalos.Pilotstudyonirreversible

electroporationwithhighfrequencypulsetrains.BMESAnnualMeeting,Hartford,CT,Oct12-15,2011.

49. ADRojas,ESchmelz,RVDavalos.Isolationofbreastcancercellsbasedonmetastaticphaseusingcontactlessdielectrophoresis.BMESAnnualMeeting,Hartford,CT,Oct12-15,2011.

50. MBSano,RVDavalos.Developmentofathree-dimensionalcontactlessdielectrophoresisplatform.

BMESAnnualMeeting,Hartford,CT,Oct12-15,2011.51. ASalmanzadeh,HKittur,RCGallo-Villanueva,MBSano,BHLapizco-Encinas,MAStremler,EM

Schmelz,RDavalos.Dielectrophoreticseparationofmouseovariansurfaceepitheliumcells.AIChEAnnualMeeting,Minneapolis,MN,Oct16-21,2011.

52. ASalmanzadeh,MSano,HShafiee,MAStremler,RVDavalos.Isolatingcancercellsfrombloodusing

contactlessdielectrophoresis(cDEP).AIChEAnnualMeeting,Minneapolis,MN,Oct16-21,2011.53. MBSano,RCGallo-Villanueva,HKittur,RDavalos.Separationofparticlesusingcontactless

dielectrophoresisandelectrokineticflow.AIChEAnnualMeeting,Minneapolis,MN,Oct16-21,2011.

54. RCGallo-Villanueva,VHPerez-Gonzalez,RDavalos,BHLapizco-Encinas.Dielectrophoretic

separationofparticlesinamulti-sectiondevice.AIChEAnnualMeeting,Minneapolis,MN,Oct16-21,2011.

55. MBSano,RDavalos.Design,development,andanalysisofamultilayercontactlessdielectrophoresis

devicetoseparatecancercellsfromblood.AIChEAnnualMeeting,Minneapolis,MN,Oct16-21,2011.

56. ASalmanzadeh,HShafiee,MSano,RDavalos.Mixingenhancementinmicrofluidicdevicesusing

contactlessdielectrophoresis(cDEP).AIChEAnnualMeeting(Bestposter),Minneapolis,MN,Oct16-21,2011.

57. ADRojas,RDavalos.Dielectrophoreticseparationofcancercellsbasedonmetastaticstage.AIChEAnnualMeeting,Minneapolis,MN,Oct16-21,2011.

58. RDavalos(invited),MSano,ARojas.Isolationofcirculatingtumorcellsfromdilutewholeblood

usingcontactlessdielectrophoresis.201138thFederationofAnalyticalChemistryandSpectroscopySocieties(FACSS)Conference,Reno,NV,Oct2-6,2011.

59. BHLapizco-Encinas,RGVillanueva,HMoncada-Hernandez,VPGonzalez,JLBaylon-Cariel,RDavalos

(invited),Developmentofinsulator-baseddielectrophoreticsystemsforhandlingbioparticles,201138thFederationofAnalyticalChemistryandSpectroscopySocieties(FACSS)Conference,Reno,NV,Oct2-6,2011.

60. MSano,HShafiee,RVDavalos.Entrapmentofhumanleukemiacellsfrombloodusingcontactlessdielectrophoresis.AIChEAnnualMeeting,SaltLakeCity,UT,Nov7-12,2010.

61. RENealII,PAGarcia,JHRossmeislJr,RVDavalos.Irreversibleelectroporationtreatmentplanning

techniques.BMESAnnualMeeting,Austin,TX,Oct6-9,2010.

62. PAGarcia,JHRossmeislJr,RVDavalos.Treatmentplanningofirreversibleelectroporationforintracranialdisorders.BMESAnnualMeeting,Austin,TX,Oct6-9,2010.

63. MBSano,EHenslee,HShafiee,RVDavalos.IsolationofCirculatingCancerCellsFromDiluteWholeBloodSamplesUsingContactlessDielectrophoresis.BMESAnnualMeeting,Austin,TX,Oct6-9,2010.

64. ASalmanzadeh-Dozdabi,HShafiee,RVDavalos,MAStremler. MixingEnhancementinMicrofluidicDevicesUtilizingContactlessDielectrophoresis(cDEP).BMESConference,Austin,TX,Oct6-9,2010.

65. PAGarcia,JRossmeislJr,TEllis,JRobertson,RVDavalos(invited).Non-thermalirreversibleelectroporation(N-TIRE)forintracranialmalignantgliomainacaninepatient.ElectricFieldsEffectsinTumors:BiophysicalFoundationsandClinicalExperiences.IEEEEngineeringinMedicineandBiologySociety,BuenosAires,Argentina,Aug31-Sep5,2010.

66. PAGarcia,RVDavalos.Cumulativevisualizationofamultiple-electrodeirreversibleelectroporation

treatment.GordonResearchConference:Bioelectrochemistry,UniversityofNewEngland,MA,Jul

11-16,2010.67. PAGarcia,JRossmeislJr,TEllis,JRobertson,RVDavalos(invited).Non-thermalirreversible

electroporationforintracranialdisorders.7thInternationalBioelectricsSymposium,Norfolk,VA,Jun24-26,2010.

68. RVDavalos(invited),ADRojas,MBSano,PGatenholm.Biofabricationwithelectricalcontroltocreatebiocompatiblematerials.239thACSNationalMeetingandExposition,SanFrancisco,CA,Mar21-25,2010.

69. ADRojas,MBSano,PGatenholm,RVDavalos.Electrokineticbiofabricationofmicrobialcellulose-

metalcomposites.239thACSNationalMeetingandExposition,SanFrancisco,CA,Mar21-25,2010.

70. RENealII,RSingh,STorti,RVDavalos.Tumortreatmentusingirreversibleelectroporationwithaminimallyinvasivesingleneedleelectrode.ElectroporationBasedTechnologiesandTreatments,Ljubljana,Nov16-21,pp149,2009.

71. PAGarcia,JHRossmeislJr,JLRobertson,RVDavalos.Intracranialnon-thermalirreversibleelectroporation:Electricalconductivityanalysis.ElectroporationBasedTechnologiesandTreatments,Ljubljana,Nov16-21,pp151,2009.

72. MBSano,ARojas,PGatenholm,RVDavalos.Directcontrolofbiologicalassemblyusing

electrokineticforces.AIChEAnnualMeeting,Nashville,TN,Nov8-13,p72b,2009.73. RVDavalos(invited),HShafiee,JLCaldwell,MBSano.Dielectrophoreticcellandmicroparticle

manipulationwithoutelectrode-samplecontact.200936thFederationofAnalyticalChemistryandSpectroscopySocieties(FACSS)Conference,Louisville,KY,Oct18-22,2009.

74. RENealII,RSingh,STorti,RVDavalos.Theeffectofheterogeneoustissueonelectricfield

distributionwhenplanningirreversibleelectroporationprotocols.HumboldtKollegonNano-Bio:TheNextTransformativeConvergence,Roanoke,VA,Oct14-15,2009.

75. RENealII,RVDavalos.Theeffectofheterogeneoustissueonelectricfielddistributionwhenplanningirreversibleelectroporationprotocols.2009BMESAnnualMeeting,Pittsburgh,PA,Oct7-10,2009.

76. MBSano,RVDavalos.Contaminationfreecellidentificationandsortingusingcapacitivedielectrophoresis.2009BMESAnnualMeeting,Pittsburgh,PA,Oct7-10,2009.

77. HShafiee,JLCaldwell,MBSano,RVDavalos.Contaminationfreecellidentificationandsortingusingcapacitivedielectrophoresis.2009BMESAnnualMeeting,Pittsburgh,PA,Oct7-10,2009.

78. RVDavalos(invited).Irreversibleelectroporationtechnology.InternationalMeetingoftheSociety

forCNSInterstitialDeliveryofTherapeutics(SCIDOT),ClevelandClinic,Cleveland,OH,Sep11-12,2009.

79. HShafiee,JLCaldwell,MBSano,RVDavalos.Sampleenrichmentandcellseparationusingcontactlessdielectrophoresis.GEM4SummerSchoolonCellularandMolecularMechanics,UrbanaChampaign,IL,Jun8-19,2009.

80. RVDavalos(invitedplenaryspeaker).Irreversibleelectroporationforcancertreatment.45th

AnnualMeetingoftheSocietyforCryobiology,Charlotte,NC,Jul20-23,Cryobiologyvol57(3),pp318,2008.

81. RVDavalos(invited),TIWallow,AMMorales,KKrafcik,BASimmons.Theapplicationofinsulator-baseddielectrophoresispolymermicrofluidicdevicesasparticleseparatorsandtheimpactofdynamicsurfacecoatingsonperformance.ASABE–AnInternationalConferenceonBiologicalSensors:CriticalTechnologiesforFutureBiosystems,Minneapolis,MN,Jun15-17,2007.

82. BASimmons,RVDavalos,AMMorales,KKrafcik,PPonce,KLuongo.Theapplicationofinsulator-baseddielectrophoresispolymermicrofluidicdevicesasparticleseparatorsandtheimpactofdynamicsurfacecoatingsonperformance.2007MRSSpringMeeting,SanFrancisco,CA,Apr9-13,2007.

83. AMMorales,BASimmons,RVDavalos,LADomeier,KKrafcik,BMosier.Injectionmoldedmicrofluidicdevicesforhomelandsecurityapplications.SensorWorkshop2007,Livermore,CA,Apr3-4,2007.

84. ESLee,SSBachelor,ZQIqbal,MKhine,RVDavalos.Knockdownofmacrophage’ssignalingpathwaysusingon-chipsinglecellmicro-electroporation.GordonResearchConference:Bioelectrochemistry,Aussios,France,Sep3-8,2006.

85. RVDavalos,GJMcGraw,YFintschenko,EBCummings,BASimmons.Insulator-based

dielectrophoreticpolymermicrofluidicdevicesforparticleseparationandconcentration.GordonResearchConference:Bioelectrochemistry,Aussios,France,Sep3-8,2006.

86. RVDavalos,GJMcGraw,PPonce,PSabounchi,TWallow,AMMorales,KKrafcik,GJFiechtner,YFintschenko,EBCummings,BASimmons.Insulator-baseddielectrophoreticpolymermicrofluidicdevicesforparticleseparationandenrichment.2006ScientificConferenceonObscurationandAerosolResearch,BattelleEasternScienceandTechnologyCenter,Aberdeen,Maryland,Jun28-29,2006.

87. RVDavalos(invited),ESLee,DRobinson,JLRognlien,CKHarnett,BASimmons,CRBEllis.A

microfluidicplatformfordrugscreeninginabiologicallyrelevantnanoenvironment.Nanotechnology:CommercializationofDrugDiscovery,DeliveryandDiagnostics,StrategicResearchInstitute,Cambridge,MA,Oct3-4,2005.

88. BASimmons,YFintschenko,EBCummings,RDavalos,GJFiechtner,GJMcGraw.Polymericsubstratesforhigh-throughputseparationandconcentrationofbiologicalagents.AbstractsofPapers,230thACSNationalMeeting,Washington,DC,Aug28-Sep1,2005.

89. EBCummings(invited),BASimmons,RVDavalos,GJMcGraw,BHLapizco-Encinas,YFintschenko.Fastandselectiveconcentrationofpathogensbyinsulator-baseddielectrophoresis.AbstractsofPapers,230thACSNationalMeeting,Washington,DC,Aug28-Sep1,2005.

90. GJMcGraw,RVDavalos,JDBrazzle,JHachman,MHunter,JChames,GJFiechtner,EBCummings,Y

Fintschenko,BASimmons.Polymericinsulator-baseddielectrophoresis(iDEP)forthemonitoringofwater-bornepathogens.ASPE,Columbus,OH,Apr18-19,2005.

91. GJMcGraw,RVDavalos,EBCummings,YFintschenko,GJFiechtner,BASimmons.Scalabilityofinsulator-baseddielectrophoresis(iDEP)anditsutilizationasahigh-throughputparticleconcentrator.PolymerPreprints-ACSDivisionofPolymerChemistry,vol46(2),pp1208,2005.

92. YFintschenko,BHLapizco-Encinas,EBCummings,RVDavalos,BASimmons.Microfluidicapproachestosampleconcentration.JointInternationalMeeting-206thMeetingoftheElectrochemicalSociety/2004FallMeetingoftheElectrochemicalSocietyofJapan,Honolulu,HI,Oct3-8,pp2475,2004.

93. PFCaton,GSChirica,BLHaroldsen,SAPizarro,RVDavalos,BASimmons,EBCummings.Rapid

automatedsamplepreparationforbiologicalsensorsandanalysissystems.SampleProcessingWorkshop,Williamsburg,VA,Sep1,2004.

94. RVDavalos,DMOtten,LMMir,BRubinsky.Molecularmedicalimagingthroughelectricalimpedancetomographyofelectroporation.GordonResearchConference:Bioelectrochemistry,NewLondon,CT,Jul25-30,2004.

95. RVDavalos,BRubinsky.Real-timeevaluationofcryosurgerythroughelectricalimpedancetomography.XVIIthInternationalSymposiumonBioelectrochemistryandBioenergetics,Florence,Italy,Jun19-24,2003.

SELECTEDPATENTS(14ISSUED)1. RVDavalos,TDouglas,JCemazar.Contactlessdielectrophoresisdevicewithcell-sizediameter

insulatingpillars.U.S.PatentApplication62/278,485.Filed:1/14/16Pending.2. RVDavalos,PAGarcia,JRossmeisl,RENeal,JLRobertson.Treatmentplanningforelectroporation-

basedtherapies.USPatentApplication12/906,923Issued12/1/15PatentNo9,198,733.3. PAGarcia,RVDavalos.Systemandmethodforestimatingatreatmentvolumeforadministering

electricalenergybasedtherapies.Filed:8/28/13USPatentApplication14/012,832Issued3/15/16PatentNo9,283,051.

4. RVDavalos,BRubinsky.Tissueablationwithirreversibleelectroporation.USApplication

10/571,162.Filed:12/24/04Issued4/14/15PatentNo9,005,189.5. RVDavalos,CBArena,JLCaldwell.Integrationofveryshortelectricpulsesforminimallyto

noninvasiveelectroporation.USApplication12/757,901.Filed:4/9/10,Issued1/6/15PatentNo8,926,606.

6. CBArena,RVDavalos,MBSano.Highfrequencyelectroporationforcancertherapy.USApplication

13/332,133PCT/US2011/066239.Filed:12/20/11Pending.

7. MBSano,RVDavalos,PGatenholm.Advancednanomaterialsandatechnologyplatformforbiofabricatingthem.USApplication61/166,508.ProvisionalFiled:4/3/09Pending.

8. MBSano,RVDavalos,JLRobertson,RENeal,PAGarcia.Irreversibleelectroporationusingtissue

vasculaturetotreataberrantcellmassesorcreatetissuescaffolds.USApplicationPCT/US2011/062067.Filed:11/23/11Pending.

9. MBSano,JLCaldwell,RVDavalos.Devicesandmethodsforcontactlessdielectrophoresisforcellor

particlemanipulation,PCTApplicationNo.:PCT/US2011/055381,Filed:10/7/11Pending.10. PGatenholm,HBackdahl,TJTzavaras,RVDavalos,MBSano.Threedimensionalbioprintingof

biosyntheticcellulose(BC)implantsandscaffoldsfortissueengineering.USApplication61/246,210.PCT/US2010/050460.ProvisionalFiled:9/28/09,Filed:9/28/10USApplication13/498,657Filed3/28/12Issued4/8/14PatentNo8,691,974.

11. RVDavalos,HShafiee,MBSano,JLCaldwell.Devicesandmethodsforcontactlessdielectrophoresisforcellorparticlemanipulation.USApplication61/158,553.ProvisionalFiled:3/9/09,Issued3/3/15PatentNo8,968,542.

12. RVDavalos,MNRylander,CBArena.Irreversibleelectroporationusingnanoparticles.USApplication12/609,779.PCT/US2009/062806.ProvisionalFiled:3/5/09,Filed:10/30/09,Issued6/18/13PatentNo8,465,484.

13. RVDavalos,MNRylander,CBArena,YWLee.Irreversibleelectroporationusingnanoparticles.US

Application12/609,779.PCT/US2009/062806.ProvisionalFiled:3/5/09,Filed:10/30/09,Issued8/26/14PatentNo8,814,860.

14. RVDavalos,PAGarcia,JLRobertson,JHRossmeisl,RENeal.Irreversibleelectroporationtotreataberrantcellmasses.USApplication12/491,151.ProvisionalFiled:6/24/08,Filed:6/24/09,Issued3/28/15PatentNo8,992,517.

15. PGatenholm,RVDavalos.Electromagneticcontrolledbio-fabricationformanufacturingbiocompatiblematerials.USApplication61/131,017.ProvisionalFiled:6/4/08Pending.

16. RVDavalos.Amethodforproducingascaffoldfortissueengineeringanorgan.USApplication61/125,840.ProvisionalFiled:4/29/08Pending.

17. RVDavalos,CRBEllis.Vesicle-basedmethodandapparatusforcollecting,manipulatingand

chemicallyprocessingtracemacromolecularspecies.USApplication10/914,991.Filed:8/9/04Issued8/17/10PatentNo7,776,357.

18. RVDavalos,BASimmons,RWCrocker,EBCummings.Insulator-basedDEPwithimpedancemeasurementsforanalytedetection.USApplication11/556,685.Filed:11/3/06Issued3/16/10PatentNo7,678,256.

19. RVDavalos,BRubinsky.Tissueablationwithirreversibleelectroporation.USApplication13/237,199.Filed:9/20/11,Issued10/9/12PatentNo8,282,631.

20. RVDavalos,BRubinsky.Tissueablationwithirreversibleelectroporation.USApplication10/571,162.Filed:12/24/04Issued11/1/11PatentNo8,048,067.

21. RVDavalos,CRBEllis.Vesicle-basedmethodandapparatusforcollecting,manipulatingand

chemicallyprocessingtracemacromolecularspecies.USApplication10/914,991.Filed:8/9/04Issued3/4/08PatentNo7,338,796.

GRADUATESTUDENTSANDSELECTEDAWARDS1. PauloGarcia(PhDBME,Fall2010)

Post-doc,Harvard-MIT,Prof.CullenBuie,13-presentVirginiaTechKnowledgeWorksawardsTechTransferChallengeprize,12PaulE.TorgersenStudentResearchExcellenceAward:BestPhDPresentation,1026thAnnualResearchSymposiumandExpositionOralCompetition:SecondPlace,10SBES9thAnnualGraduateStudentResearchSymposium:BestPresentation,10IEEEEMBSStudentPaperCompetition:NorthAmericanFinalist,09

2. HadiShafiee(PhDESM,Fall2010)AssistantProfessor,HarvardMedicalSchoolPost-doctoral,Harvard-MIT,Prof.UtkanDemirci,11-14F32NIHPostdoctoralFellowship,12PaulE.TorgersenStudentResearchExcellenceAward:PhDFinalist,1026thAnnualResearchSymposiumandExpositionPosterCompetition:FirstPlace,10LiviuLibrescuMemorialScholarship,09GEM4-CellularandMolecularMechanics:UIllinois–UrbanaChampaign:BestPoster,09

3. JohnCaldwell(MSEECS,Spring2010)TexasInstrumentsNationalDesignCompetition:FirstPlace,09Engineer,LeadershipDevelopmentProgram,TexasInstruments,10-present

4. ErinHenslee(MSBME,Spring2010)WhitakerInternationalFoundationFellowship,10-11UniversityofSurrey,BiomedicalEngineeringAdvisor:Prof.MichaelP.Hughes

5. MikeSano(MSESM,Spring2009,PhDSBES,Summer2012)Post-doc,StanfordUniversity,14–presentDoDpost-doctoralFellowship,15VirginiaTechKnowledgeWorksawardsTechTransferChallengeprize,12CEO,VoltMedLLC,Blacksburg,VA,12-presentPaulE.TorgersenGraduateStudentResearchExcellenceAward,09

6. AndreaRojas(MSMSE,Spring2012)InitiativeforMaximizingStudentDiversity(IMSD)NIHFellowship,10-11ProductDevelopment,TerumoMedicalCorporation,Elkton,MD,16-presentEngineer,W.L.Gore&Associates,Elkton,MD,12-15InitiativeforMaximizingStudentDiversity(IMSD)NIHFellowship,10-11

7. RobertNealII(PhDSBES,Fall2011)VirginiaTechOutstandingDissertationAward,12WhitakerInternationalFoundationFellowship,11PaulE.TorgersenStudentResearchExcellenceAward:BestPoster,11Post-doctoral,TheAlfredHospital,MelbourneAustralia,Dr.KenThomson

8. ElizabethSavage(MSBME,Spring2013)MultiSTEPSIGEPFellowship,11-12

InterdisciplinaryResearchSymposiumPosterAward,12SpotlightSpeakerChair,InterdisciplinaryResearchHonorsSociety,12-13Consultant,Poly-Med,Inc.inAnderson,SC13-present

9. ChrisArena(PhDSBES,Spring2013)AssistantProfessor,ElonUniversity,15–presentPost-doctoralFellow,BiomedicalEngineering,UniversityofNorthCarolina,13–15RichardSkalakAward,ASMEJournalofBiomechanicalEngineering,14CollegeofEngineeringGraduateStudentoftheYear,131stPlacePodiumPh.D.StudentPaperCompetition,ASMESummerBioengineeringConference,12.1stPlaceVirginiaTechKnowledgeWorksTechTransferChallenge,12VirginiaTechGraduateStudentAssemblyTravelFundProgramAward,12NSFJohnChatoMemorialSymposiumTravelAward,113rdPlacePodiumPh.D.StudentPaperCompetition,ASMESummerBioengineeringConference,11

10. AlirezaSalmanzadeh(PhDESM,Spring2013) SeniorEngineer,BDBiosciences,SanJose,16-presentPost-doc,UniversityofCalifornia,Berkeley(LukeLee),14-15PaulE.TorgersenStudentResearchExcellenceAward:BestPhDPresentation,13AmirChandandDewkiBaiBatraScholarship,13VirginiaTechGraduateManoftheYear,12OutstandingGraduateStudentLeaderAward,12AmericanElectrophoresisSociety:PosterAward,12AmericanElectrophoresisSociety:PosterAward,11VirginiaTechCancerSymposium:Co-Chair,11ManualSteinScholarship,10

11. EduardoLatouche(MSESM,Spring2016)PaulE.TorgersenStudentResearchExcellenceAward:BestMSPresentation,15BMES-FDAFrontiersinMedicalDevicesConference:Firstrunneruppodium,16SeniorEngineer,VoltMed,Blacksburg,VA16–present

12. MattDeWitt(PhDSBES(Co-advisor),Summer2016)MatthewDeWitt(PhDSBES(Co-advisor),Summer2016)CunninghamDoctoralFellowship:11-16ASMEHeatTransferConference:InvitedPanelistonThermalMedicine,14NationalScienceFoundation(NSF)GraduateResearchFellowship(GRFP),12-15SeniorR&DEngineer,BostonScientific,MN16-Present