Quantitative modeling of chronic myeloid leukemia: insights from radiobiology

by Tomas Radivoyevitch, Lynn Hlatky, Julian Landaw, and Rainer K. Sachs

BloodVolume 119(19):4363-4371

May 10, 2012

©2012 by American Society of Hematology

Cell population dynamic CML models.

Tomas Radivoyevitch et al. Blood 2012;119:4363-4371

©2012 by American Society of Hematology

TKI discontinuation possibilities illustrate deterministic versus stochastic modeling differences.

Tomas Radivoyevitch et al. Blood 2012;119:4363-4371

©2012 by American Society of Hematology

CML latency time T. T is here considered as a random variable, that is, a quantity described by a probability density because it may fluctuate from case to case in a way not (yet) fully predictable.

Tomas Radivoyevitch et al. Blood 2012;119:4363-4371

©2012 by American Society of Hematology

Atomic bomb survivor waiting times.

Tomas Radivoyevitch et al. Blood 2012;119:4363-4371

©2012 by American Society of Hematology

Age dependence of background CML incidence and translocation prevalence.

Tomas Radivoyevitch et al. Blood 2012;119:4363-4371

©2012 by American Society of Hematology

CML incidence versus age at radiation exposure for different dose groups.

Tomas Radivoyevitch et al. Blood 2012;119:4363-4371

©2012 by American Society of Hematology

Proximity effects.

Tomas Radivoyevitch et al. Blood 2012;119:4363-4371

©2012 by American Society of Hematology