quality control method of herbal medicine
TRANSCRIPT
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QUALITY CONTROL METHOD OF
HERBAL MEDICINE
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Yang dianalisis
Simplisia utuhSerbuk simplisiaEkstrak simplisia
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SAMPLING
Sample in Bulk1 batch: 6- 50 unit, sampel yg diambil 5 unit1 batch > 50 unit, sampel yg diambil 10%
paling mendekati dengan jumlah kelipatan 10Sample in retail packageKarton ambil sampel pada bagian atas,
tengah, bawahBungkus diambil secara acak menggunakan
tangan dengan kedalaman +/- 10 cm
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Setelah pengambilan sampel, diamati:
SAMPLING...
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QC OF HERBAL MEDICINE
1. Analisis makroskopik dan mikroskopik2. Penetapan kadar abu3. Penetapan bahan terekstraksi4. Penetapan cemaran mikroba5. Penetapan arsen dan logam toksik6. Penetapan minyak atsiri7. Penetapan kadar tanin8. Penetapan aktivitas hemolisis9. Penetapan indeks busa10. Penetapan residu pestisida
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Analisis makroskopik
Petunjuk khusus adalah morfologi dan ciri-ciri organoleptik. Simplisia dipisah-pisahkan satu dari lainnya sesuai dengan ciri-ciri morfologis serta ciri lainnya( bau, warna, ukuran,tekstur) kemudian setiap simplisia ditimbang.
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ANALISIS MIKROSKOPIK
Kualitas obat herbal dapat ditentukan oleh ada/tidaknya dan jumlah sel tertentu
Yang biasa diamati secara mikroskopik:1. Amilum2. Aleuron3. Sel lemak4. Minyak
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Reagen yang digunakan:1. Kloralhidrat
melarutkan amilum, aleuron, lemak dan minyakbest reagen for kalsium oksalat (use heat)
2. Laktokloralsama dgn kloralhidrat tetapi digunakan dingin
ANALISIS MIKROSKOPIK ...
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Reagen yang digunakan:3. Laktofenol
bagus untuk mengamati amilumdapat digunakan dalam keadaan panas dan dinginCa-oksalat terlihat jelas
4. Na-hipoklorit 5. Xylene R dan petroleum R
ANALISIS MIKROSKOPIK ...
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Deteksi histokimia (dinding sel, stomata) Paling sering: INDEKS STOMATA digunakan pada sediaan herbal yg
menggunakan daun
ANALISIS MIKROSKOPIK ...
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a. AnomositikRanunculaceae
b. AnisositikCruciferaceae
c. DiasitikCaryophyaceae
d. ParasitikRubiaceae
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Perhitungan Indeks Stomata
a. Penetapan dilakukan pada 10 pengamatan, indeks stomata hasil perhitungan adalah indeks stomata rata-rata
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Analisis Mikroskopik lain
1. NISBAH PALISADE ?2. PULAU TULANG DAUN ?3. METODE LIKOPODIUM ?
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PENETAPAN KADAR ABU
Metode penetapan kadar abu dibedakan menjadi 3, yaitu:
1. Kadar abu total2. Kadar abu larut air3. Kadar abu larut asam
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PENETAPAN KADAR ZAT TEREKSTRAKSI
Penetapan jumlah konstituen aktif yang terekstraksi dalam pelarut
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PENETAPAN KADAR ZAT TEREKSTRAKSI ...
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PENETAPAN KADAR AIR
Mengapa air perlu diketahui kadarnya?
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mmX Bbbznnznnnnnn
Metode Distilasi Toluen/Azeotrop
1. Simplisia/jamu yg mengandung 2- 3 ml air dimasukkan dalam flask
2. Masukkan porous porcelain, panaskan
3. Panaskan perlahan 15’, setelah mendidih hitung kecepatan 2 -4 tetes per detik
4. Setelah air terdestilasi semua, cuci pendingin dengan toluen (baca volume air-n)
5. Lanjutkan destilasi 5’6. Hasil distilasi didiamkan supaya
volume air dan toluen memisah7. Baca volume air (n1)
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Perhitungan Kadar Air
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Metode GRAVIMETRI
PENETAPAN KADAR AIR...
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ANALISIS CEMARAN LOGAM BERAT
Agustina Setiawati, M.Sc., Apt
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PENDAHULUANPrinsip : Menentukan kandungan logam berat
secara spektroskopi serapan atomTujuan : memberi jaminan ekstrak tidak
mengandung logam berat tertentu (Pb, Cd, As) melebihi nilai yang ditetapkan karena toksik
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PENDAHULUANBatas nilai:
Pb 10 mg/kgCd 0,3 mg/kgAs 10 ug /kg
Efek logam beratAs: astroenteritis,,kelumpuhan,diarehiperkeratosis,daya reflek menurun
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Cd :sakit kepala, gangguan saluran penafasan,gangguan kardiovaskuler,hipertensi
Pb : anemia,gangguan fungsi tiroid,gangguan ginjal.
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Lampu katodaPb pada panjang gelombang 217,0 nmCd pada panjang gelombang 228,8 nmAs pada panjang gelombang 193,7 nm(SNI 06-6992.3-2004)
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Pembuatan kurva bakuBaku Pb,Cd,As dibuat dalam beberapa seri
konsetrasi dalam pelarut asam nitrat.Baca absorbsinya sesuai panjang gelombang
sesuai jenis logam.
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Preparasi sampelEkstrak ditambah asam nitrat dan asam
perklorat pekat , panaskan sampai jernih, pemanasan dilanjutkan 30 menit.Dinginkan , tambah air.
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Asam nitrat melarutkan logam4HNO3 ----2H2O + 4NO + 3 O22 Pb + O2 ----2PbOPbO + 2H+ +2NO3- -Pb(NO3)2 +H2OMenghilangkan kelebihan asam nitratHClO4---HCl + 2O22HNO3 + O2 ---H2O +N2O3 + 2O2
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Pembuatan kurva bakuBaku Pb,Cd,As dibuat dalam beberapa seri
konsetrasi dalam pelarut asam nitrat.Baca absorbansinya sesuai panjang
gelombang sesuai jenis logam.
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Buat kurva hubungan antara absorbansi dengan konsentrasi
Cari persamaan kurva baku
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Pengukuran sampelSampel diukur pada panjang gelombang
sesuai jenis logam.Absorbansi masukan persamaan kurva baku
sehingga diperoleh kadar logam berat