Preliminary Program Neutrophil 2018 International SymposiumHôtel Château Laurier, Québec, Qc, CanadaJune 2-5, 2018

15h00-18h00 On-site registration begins19h00 Introductory remarks Co-chairs (P McDonald, PE Poubelle)19h15-20h00 Keynote Lecture: Dr Paul Kubes (University of Calgary, Canada)

Live fast, die young, and leave a good-looking corpse 20h15 Welcoming Reception and Light Dinner, Ballroom Foyer

Saturday, June 2

Neutrophil 2018Québec City, June 2-5

8h00 Continental breakfast, Ballroom Foyer

Session I: Classic Neutrophil FunctionsChairs: SG Bourgoin, M Pouliot, OE Sørensen

8h30- 9h00 Ole E. Sørensen (Lunds Universitet, Lund, Sweden)Niels Borregaard – a life in science devoted to neutrophil granules

9h00- 9h30 Anthony W. Segal (University College London, London, UK)Vacuolar pH, its regulation and role in microbial killing

9h30- 10h00 Anna Huttenlocher (University of Wisconsin, Madison, USA)Reverse neutrophil migration and resolution of inflammation

10h00- 10h30 Hongbo R. Luo (Harvard Medical School, Boston, USA)Regulation of neutrophil function by inositol hexakisphosphate kinase 1 (IP6K1)

10h30-10h45 Coffee break10h45-11h15 Edwin R. Chilvers (University of Cambridge, UK)

Neutrophil priming: a one way ticket?11h15- 11h45 Selected talks from abstracts

Poster session11h45-12h30 Poster session12h30-13h30 Lunch

Session II: Neutrophil Extracellular TrapsChairs: J-P Lavoie, PP McDonald, DD Wagner

13h30- 14h00 Denisa D. Wagner (Harvard Medical School, Boston, USA)NETs: nuclear weapons of inflammation

14h00- 14h30 Johan van der Vlag (Radboud University, Nijmegen, The Netherlands)The ins and outs of NETs

14h30- 15h00 Balázs Rada (University of Georgia, Athens, GA, USA)Neutrophil extracellular traps in cystic fibrosis airway disease

15h00- 15h30 Martin Herrmann (Friedrich-Alexander-Universität, Erlangen, Germany)Neutrophils, NETs and aggNETs contribute to initiation and resolution of inflammation

15h30-15h45 Coffee break15h45- 16h15 Discussion on NETs

Trainees’ Session : Part 1Chairs: Marc Pouliot, Sarah Walmsley16h15- 17h15 Four oral presentations selected from abstracts (12’ + 3’ discussion)

Poster session17h15- 18h15 Poster rooms

Sunday, June 3

8h00 Continental breakfast, Ballroom Foyer

Session III: Emerging Topics in Neutrophil BiologyChairs: M Fernandes, T Lämmerman, S Renshaw

8h30- 9h00 Tim Lämmerman (Max-Planck-Institut, Freiburg, Germany)Neutrophil swarming at sites of inflammation and infection

9h00- 9h30 Sarah Walmsley (University of Edinbugh, UK)Hypoxia, metabolism and neutrophilic inflammation

9h30- 10h00 Venizelos Papayanopoulos (The Francis Crick Institute, London, UK)((title to come))

10h00- 10h30 Selected talks from abstracts 10h30-10h45 Coffee break

Session IV: Plenary WorkshopsNOMENCLATURE OF NEUTROPHIL SUBSETS / NEW METHODOLOGIESChairs: M. Glogauer, J-P Lavoie, PE Poubelle

10h45-11h00 Michael Glogauer (University of Toronto, Canada)A pro-inflammatory first responding neutrophil activation subset is augmented during emergency granulopoiesis and neutropenia

11h00-11h15 Steven W. Edwards (University of Liverpool, UK)Genetic reprogramming in human neutrophils during inflammation

11h15-11h30 Leo Koenderman (University Medical Center Utrecht, The Netherlands)Kinetics of human neutrophil subsets in blood and bone marrow

11h30-11h45 Patrizia Scapini (Università di Verona, Italy)Neutrophil heterogeneity in acute and chronic inflammatory conditions

11h45-12h00 Daniel Irimia (Harvard Medical School, Boston, USA) Microscale tools for probing neutrophil sepsis, swarming, and interactions with microbes

12h00- 12h45 Discussion on Neutrophil subsets / New methodologies

12h45-14h00 Lunch

Trainees’ Session : Part 2Chairs: M Pouliot, S Walmsley

14h00-14h45 Three oral presentations selected from abstracts (12’ + 3’ discussion)14h45-15h00 Coffee break

Home-grown scienceChairs: PP McDonald, PE Poubelle

15:00-15:30 Martin Pelletier (Université Laval, Québec, Canada)Targeting neutrophil metabolism to control inflammatory responses

15:30-16:00 Nicolas Flamand (Université Laval, Québec, Canada)Neutrophils and the cannabinoid system: crosstalk with eicosanoids

Monday, June 4

Session V: Neutrophils in Adaptive Immunity and BeyondChairs: M Fernandes, J Filep, MC Karlsson

16h00-16h30 Mikael C. Karlsson (Karolinska Institutet, Stockholm, Sweden)Neutrophil regulation of autoreactive B cell responses

16h30-17h00 Luc Vallières (Université Laval, Québec, Canada)Pervasive effects of neutrophils in B cell-dependent autoimmune demyelination

17h00-17h30 Marco A. Cassatella (Università di Verona, Verona, Italy)Advances on the molecular regulation of gene expression in human neutrophils

17h30-18h00 Selected talks from abstracts18h00 Cocktails and Poster Awards 19h30 Pub Dinner (optional)

8h00 Continental breakfast, Ballroom Foyer

Session VI: Neutrophils in Autoimmune Disease and CancerChairs: G DiBattista, PE Poubelle, O Söhnlein

8h30- 9h00 Oliver Söhnlein (Klinikum der Universität München, Munich, Germany)Kiss of death: neutrophils kill smooth muscle cells to induce atherosclerotic plaque destabilization

9h00- 9h30 Mariana J. Kaplan (National Institutes of Health, Bethesda, USA) Neutrophils and their death in the pathogenesis of systemic autoimmune diseases

9h30- 10h00 Peter A. Nigrovic (Harvard Medical School, Boston, USA) New insights into CD177 biology

10h00- 10h30 Zvi Fridlender (Hadassah Medical Center, Jerusalem, Israel)Different sub-populations of cancer-related neutrophils, their activation and recruitment into tumors

10h30- 11h00 Stephen Renshaw (University of Sheffield, UK)Reverse migration as a therapeutic target in inflammation resolution

11h00-11h30 Selected talks from abstracts

11h30- 11h45 Concluding remarksPP McDonald, PE Poubelle, S Renshaw

Tuesday, June 5