2004

Pyran derivativesR 0340 Pyran-Containing Sulfonamide Hydroxamic Acids: Potent MMP Inhibitors that

Spare MMP-1. — The synthesis of a variety of title compounds such as (VIII) and (IX) and evaluation of their structure—activity relationships are described. Compounds (VIII) and (IXb) are identified as potent inhibitors of MMP-13 that spare MMP-1. — (REITER*, L. A.; et al.; Bioorg. Med. Chem. Lett. 14 (2004) 13, 3389-3395; Groton Lab., Pfizer Global Res. Dev., Groton, CT 06340, USA; Eng.) — M. Schroeter

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