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Introduction: It has been shown that high intensity training is more effective in treatingpatients with heart failure (HF) however studies haven’t been evaluated sexual function.Objectives: To compare moderate versus high intensity exercise with regard to sexual andcardiorespiratory function.Methods: Twenty patients with stable HF (aged 53.25 � 8.87 years), left ventricle ejectionfraction � 45%, were randomized to moderate continuous training (MCT) or high-in-tensity interval training (HIT). The subjects underwent 12 weeks of exercise training, threetimes per week, in MCT target zone of heart rate (HR) corresponding to anaerobicthreshold (first ventilatory threshold) and in HIT the HR corresponding to respiratorycompensation point (second ventilatory threshold) alternating with HR corresponding toanaerobic threshold (recovery period). Patients underwent assessment of sexual function bythe International Index of Erectile Function (IIEF), determination of VO2 peak by car-diopulmonary exercise testing (CPET), determination of distance walk by the six-minutewalk test (6MWT) and assessment of endothelial function by Doppler echocardiography. Instatistical analysis was used Shapiro-Wilk test, Chi-square (x2), Fisher exact test, t test,Mann-Whitney U and paired t test, with significance level of 5%.Results: Only in HIT was observed increase in erectile function (11 � 10.46 to 19.55 �9.07, p ¼ 0.030), desire (from 4.77 � 2.04 to 6.88 � 2.08, p ¼ 0.034), sexual satisfaction(from 4.00 � 4.63 to 8.33 � 5.36, p ¼ 0.017) and VO2 peak (from 21.07 � 4.30 to 23.79� 5.26, p ¼ 0.021) while in MCT was no significant changes in these outcomes. Distancewalked in 6MWT increased after MCT (462.63 � 63.10 to 603.45 � 67.50, p ¼ 0.003)and HIT(456.44 � 38.51 to 589.66 � 59, 69, p ¼ 0.008). No significant changes occurredin endothelial function (HIT: +43.6%, p ¼ 0.666; MCT:+193%, p ¼ 0.214).Conclusion: High-intensity training was superior than MCT for increase sexual andcardiorespiratory function in patients with heart failure.Disclosure of Interest: None Declared

PW042

Predictors of Mortality in Patients With Hypertrophic Cardiomyopathy - A HospitalAdmissions Study: 2000-2013

Niece K. Khouw1, Mohammed Wasim1, Hardeep Uppal2, Suresh Chandran3, Rahul Potluri*41General Medicine, Pennine Acute Hospital NHS Trust, Manchester, 2Coventry andWarwickshire Partnership NHS Trust, Coventry, 3Acute Medicine, Pennine Acute Hospital NHSTrust, Manchester, 4ACALM Study Unit in collaboration with School of Medical Sciences, AstonUniversity, Birmingham, United Kingdom

Introduction: Hypertrophic Cardiomyopathy (HCM) is a rare condition that can beassoociated with sudden cardiac death. The predictors of mortality in patients with HCMhas not been well studied.Objectives: The aim of this study is to investigate the predictors of mortality in patientswith HCM from a large sample of hospital admissions.Methods: Anonymous information on patients with Hypertrophic Cardiomyopathy, co-morbidities and procedures attending large multi-ethnic general hospitals in Manchester,United Kingdom in the period 2000-2012 was obtained from the local health authoritycomputerised hospital activity analysis register using ICD-10 and OPCS coding systems.Statistical analysis was performed using SPSS version 20.Results: Out of 1,221,216 patients admitted, there were 253 patients with HCM. Themean age of 55.8years�18.8(S.D) with 63.2% male patients VS 36.8% female patients. Themain co-morbidities were Hypertension (86;34.0%), Atrial Fibrillation (69;27.3%), HeartFailure (27;10.7%), Type 2 Diabetes Mellitus (24;9.5%), Ventricular Tachycardia(16;6.3%), Defibrillator Implant (16;6.3%). A multi-nominal logistic regression modelaccounting for variations in age, sex and ethnic group showed that only Atrial Fibrillation(RR3.8;C.I1.7-8.1) and Heart Failure (RR5.0;C.I1.9-13.5) are significant predictors ofmortality (p <0.05).Conclusion: We have shown that Atrial Fibrillation and Heart Failure are significantpredictors of mortality in patients with HCM from a large hospital based sample in the UK.This reflects the known complications of HCM affecting mortality. However, it is surprisingthat Defibrillator implantation does not confer improved mortality. Our improved un-derstanding of these predictors will guide clinicians to focus on these high risk groups toimprove clinical practice and outcomes in patients with HCM.Disclosure of Interest: None Declared

PW043

Predictors of outcome in takotsubo cardiomyopathy – a multicenter study

Nuno S. Marques*1, Olga Azevedo2, Inês Cruz3, Bruno Piçarra4, Rui Lima5, José Amado1,Vitor Pereira2, Ana Rita Almeida3, SUNSHINE1Cardiology, Faro Hospital, Faro, 2Cardiology, CHAA, Guimarães, 3Cardiology, H. Garcia Orta,Almada, 4Cardiology, H. Évora, Évora, 5Cardiology, H. Viana do Castelo, Viana do Castelo,Portugal

Introduction: Takotsubo cardiomyopathy (TC) is characterized by a transient left ven-tricular (LV) dysfunction in the absence of significant coronary artery disease. The pre-dictors of prognosis of TC are not yet fully established.Objectives: To identify predictors of outcome in patients (P) diagnosed with TC.Methods: Multicenter studyinvolving 5 hospital centers that included all patients diag-nosed with TC in the last 10 years. We assessed demographic data, precipitating factors andclinical presentation, trying to establish the predictors of after discharge outcomes.Results: We included 71 P diagnosed with TC. During hospitalization (6.1 � 4.6 days)occurred complications: heart failure (31%), cardiogenic shock (15.5%), atrial fibrillation(9.9%), complete atrioventricular block (4.2 %), acute pulmonary edema (4.2%), stroke /TIA (2.8%), LV thrombus (1.4%) and death (1.4%).

GHEART Vol 9/1S/2014 j March, 2014 j POSTER/2014 WCC Posters

Over a follow-up of 31 � 29 months, there were: TC recurrence (4.2%), stroke / TIA(4.2%) and death (1.4%).The following variables were identified as predictors of complications at follow-up: (i) ST

segment depression on admission EKG was a predictor of TC recurrence (p¼0,016); (ii)Chronic renal failure was a predictor of stroke/TIA (p¼0.023) and death (p¼0,027).Conclusion: TC has a low rate of complications in the follow-up. Chronic renal failure is apredictor of death and also of stroke in the follow-up. The admission EKG may have aprognostic role and ST segment depression was the only identified predictor of TCrecurrence. Our results need confirmation in larger studies.Disclosure of Interest: None Declared

PW044

Predictors of in-hospital outcome in takotsubo cardiomyopathy – A multicenter study

Nuno S. Marques*1, Olga Azevedo2, Inês Cruz3, Bruno Piçarra4, Rui Lima5, José Amado1,Vitor Pereira2, Ana Rita Almeida3, SUNSHINE1Cardiology, Faro Hospital, Faro, 2Cardiology, CHAA, Guimarães, 3Cardiology, H. Garcia deOrta, Almada, 4Cardiology, H. Évora, Évora, 5Cardiology, H. Viana do Castelo, Viana doCastelo, Portugal

Introduction: Takotsubo cardiomyopathy (TC) is characterized by a transient left ven-tricular (LV) dysfunction in the absence of significant coronary artery disease. The pre-dictors of prognosis of TC are not yet fully established.Objectives: To identify predictors of outcome in patients (P) diagnosed with TC.Methods: Multicenter study involving 5 hospital centers that included all patients diag-nosed with TC in the last 10 years.Results: We included 71 P diagnosed with TC. During hospitalization (6.1 � 4.6 days)occurred complications: heart failure (31%), cardiogenic shock (15.5%), atrial fibrillation(9.9%), complete atrioventricular block (4.2 %), acute pulmonary edema (4.2%), stroke /TIA (2.8%), LV thrombus (1.4%) and death (1.4%).In the multivariate analysis, the following variables were identified as independent

predictors of in-hospital complications: (i) Predictors of complete atrioventricular blockwere angina pectoris (p¼0,028), syncope at presentation (p¼0,012), ST segment elevationon the admission EKG (p¼0,010) and T wave inversion (p¼0,043); (ii) ST segmentdepression on the admission EKG was identified as a predictor of acute pulmonary edema(p¼0,029); (iii) LV dysfunction was an independent predictor of heart failure (p¼0,003),acute pulmonary edema (p¼0,015), stroke/TIA (p¼0,035) and death (p¼0,049); (iv) Malegender was an independent predictor of stroke/TIA (p¼0,013) and death (p<0,001); (v)Other predictors of death were diabetes mellitus (p¼0,007), chronic renal failure(p¼0,048), syncope at presentation (p¼0,036).Conclusion: TC has a high rate of complications in the acute phase. TC, a disease of mainlyfemales, has worse in-hospital prognosis in males. Male gender is a predictor of in-hospitalstroke/TIA and death. Diabetes, chronic renal failure, syncope at presentation and LVdysfunction were also predictors of in-hospital death.Disclosure of Interest: None Declared

PW045

Is prognosis of takotsubo cardiomyopathy related with the speed of recovery of leftventricular function?

Olga Azevedo*1, Nuno S. Marques2, Inês Cruz3, Bruno Piçarra4, Rui Lima5, José Amado2,Vitor Pereira1, Ana Rita Almeida3, SUNSHINE1Cardiology, CHAA, Guimarães, 2Cardiology, Faro Hospital, Faro, 3Cardiology, H. Garcia deOrta, Almada, 4Cardiology, H. Évora, Évora, 5Cardiology, H. Viana do Castelo, Viana doCastelo, Portugal

Introduction: Takotsubo cardiomyopathy (TC) is characterized by a transient left ven-tricular (LV) dysfunction. The recovery rate of LV function is variable. There is lack of datawith respect to the impact of the rate of recovery of LV function in the prognosis of TC.Objectives: To determine if the patients diagnosed with TC that present a faster recovery ofLV function have better medium term prognosis.Methods: Multicenter study involving 5 hospitals that included all patients diagnosed withTC in the last 10 years. We assessed patients with echocardiography at admission,discharge and at follow-up. Full recovery was defined as complete normalization of LVglobal function and segmental motility. We established the discharge time and 15 days afteradmission as cut-offs for recovery of LV function. We determine if the patients with fasterrecovery of LV function had better medium term prognosis.Results: We included 71 patients with TC. Total recovery of LV function was observed athospital discharge in 27 patients (38,0%) and at 15 days after admission in 31 patients(43,7%).The recovery of LV function during the hospital stay was not associated with death (0%

vs 2,7%, p¼0,437), stroke/TIA (5,4% vs 4,5%, p¼0,884) or TC recurrence (0% vs 8,1%,p¼0,170) in the follow-up. In the multivariate analysis, the faster recovery of LV functionwas not an independent predictor of events.The recovery of LV function at 15 days after admission was not associated with death

(0% vs 2,8%, p¼0,410), stroke/TIA (4,2% vs 5,6%, p¼0,809) or TC recurrence (0% vs8,3%, p¼0,147) in the follow-up. In the multivariate analysis, the faster recovery of LVfunction was not an independent predictor of events.Conclusion: In this multicenter study, the patients with TC that present a faster recovery ofLV function do not have a better medium term prognosis. However, the low rate ofcomplications in the follow-up may have limited the study results. Our results need furtherconfirmation in larger studies.Disclosure of Interest: None Declared

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