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Immunohistochemical features and staging of early gastric cancer.Gurzu S, Orlowska J, Sugimura H, Bara T, Szentirmay Z, Januszewicz W, Bara T Jr, Szederjesi J, Jung I.Arch Med Sci. 2017 Oct;13(6):1373-1382. doi: 10.5114/aoms.2016.58665. Epub 2016 Mar 22.PMID: 29181068 Free PMC Article

Mutation Spectrum Induced by 8-Bromoguanine, a Base Damaged by Reactive Brominating Species, inHuman Cells.Shinmura K, Kato H, Goto M, Tao H, Inoue Y, Nakamura S, Yoshida H, Tsuzaki E, Sugimura H.Oxid Med Cell Longev. 2017;2017:7308501. doi: 10.1155/2017/7308501. Epub 2017 Sep 30.PMID: 29098062 Free PMC Article

Application of digital PCR with chip-in-a-tube format to analyze Adenomatous polyposis coli (APC) somaticmosaicism.Kahyo T, Iwaizumi M, Yamada H, Tao H, Kurachi K, Sugimura H.Clin Chim Acta. 2017 Dec;475:91-96. doi: 10.1016/j.cca.2017.10.015. Epub 2017 Oct 18.PMID: 29055690

Retraction.Tanno Y, Susumu H, Kawamura M, Sugimura H, Honda T, Watanabe Y.Science. 2017 Sep 8;357(6355):981. doi: 10.1126/science.aap7423. Epub 2017 Sep 5. No abstract available.PMID: 28874501

Insertionally polymorphic sites of human endogenous retrovirus-K (HML-2) with long target site duplications.Kahyo T, Yamada H, Tao H, Kurabe N, Sugimura H.BMC Genomics. 2017 Jun 27;18(1):487. doi: 10.1186/s12864-017-3872-6.PMID: 28655292 Free PMC Article

Homeobox Transcription Factor NKX2-1 Promotes Cyclin D1 Transcription in Lung Adenocarcinomas.Harada M, Sakai S, Ohhata T, Kitagawa K, Mikamo M, Nishimoto K, Uchida C, Niida H, Kotake Y, SugimuraH, Suda T, Kitagawa M.Mol Cancer Res. 2017 Oct;15(10):1388-1397. doi: 10.1158/1541-7786.MCR-17-0114. Epub 2017 Jun 20.PMID: 28634225

Immunohistochemical expression analysis of leucine-rich PPR-motif-containing protein (LRPPRC), acandidate colorectal cancer biomarker identified by shotgun proteomics using iTRAQ.Nishio T, Kurabe N, Goto-Inoue N, Nakamura T, Sugimura H, Setou M, Maekawa M.Clin Chim Acta. 2017 Aug;471:276-282. doi: 10.1016/j.cca.2017.06.011. Epub 2017 Jun 13.PMID: 28622966

Characterization of V-set and immunoglobulin domain containing 1 exerting a tumor suppressor function ingastric, lung, and esophageal cancer cells.Inoue Y, Matsuura S, Yoshimura K, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Maeda M, Ogawa H, Inui N,Funai K, Shinmura K, Niwa H, Suda T, Sugimura H.Cancer Sci. 2017 Aug;108(8):1701-1714. doi: 10.1111/cas.13295. Epub 2017 Jul 29.

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PubMed sugimura haruhiko

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PMID: 28603843 Free PMC Article

A systematic review of the possible carcinogenic role of the aristolochic acid.Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I.Rom J Morphol Embryol. 2017;58(1):41-44.PMID: 28523296 Free Article

BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors.Shinmura K, Kato H, Kawanishi Y, Kamo T, Inoue Y, Yoshimura K, Sugiyama K, Misawa K, Hosokawa S,Mineta H, Sugimura H.Pathol Oncol Res. 2017 May 3. doi: 10.1007/s12253-017-0248-9. [Epub ahead of print]PMID: 28470573

Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non-smallcell lung cancer.Yoshimura K, Inoue Y, Mori K, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K,Shinmura K, Niwa H, Suda T, Sugimura H.Genes Chromosomes Cancer. 2017 Jul;56(7):570-581. doi: 10.1002/gcc.22461. Epub 2017 May 4.PMID: 28378892

Rapid Radiologic Progression of Silicosis.Tsuchiya K, Toyoshima M, Akiyama N, Kono M, Nakamura Y, Funai K, Baba S, Sugimura H, Kanayama H,Suda T.Am J Respir Crit Care Med. 2017 May 15;195(10):e39-e42. doi: 10.1164/rccm.201606-1194IM. No abstract available.PMID: 28339287

WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma.Shinmura K, Kato H, Kawanishi Y, Igarashi H, Inoue Y, Yoshimura K, Nakamura S, Fujita H, Funai K,Tanahashi M, Niwa H, Ogawa H, Sugimura H.Mol Carcinog. 2017 Aug;56(8):1984-1991. doi: 10.1002/mc.22647. Epub 2017 Mar 30.PMID: 28277612

Successful crizotinib monotherapy in EGFR-mutant lung adenocarcinoma with acquired MET amplificationafter erlotinib therapy.Yoshimura K, Inui N, Karayama M, Inoue Y, Enomoto N, Fujisawa T, Nakamura Y, Takeuchi K, Sugimura H,Suda T.Respir Med Case Rep. 2017 Feb 17;20:160-163. doi: 10.1016/j.rmcr.2017.02.009. eCollection 2017.PMID: 28271038 Free PMC Article

High expression of Wls is associated with lymph node metastasis and advanced TNM stage in gastriccarcinomas.Zhang W, Tao H, Chen X, Sugimura H, Wang J, Zhou P.Pathol Int. 2017 Mar;67(3):141-146. doi: 10.1111/pin.12508. Epub 2017 Jan 22.PMID: 28110490

Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer.Inoue Y, Yoshimura K, Kurabe N, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K,Niwa H, Suda T, Sugimura H.Oncotarget. 2017 Jan 31;8(5):8738-8751. doi: 10.18632/oncotarget.14434.PMID: 28060732 Free PMC Article

CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis.Ayhan A, Kuhn E, Wu RC, Ogawa H, Bahadirli-Talbott A, Mao TL, Sugimura H, Shih IM, Wang TL.Mod Pathol. 2017 Feb;30(2):297-303. doi: 10.1038/modpathol.2016.160. Epub 2016 Oct 21.

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A novel prognostic marker of non-small cell lung cancer: chromosome 9 open reading frame 86 (C9orf86).Yoshimura K, Osman M, Inoue Y, Suda T, Sugimura H.J Thorac Dis. 2016 Sep;8(9):2284-2286. No abstract available.PMID: 27746955 Free PMC Article

CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers.Kumondai M, Hosono H, Orikasa K, Arai Y, Arai T, Sugimura H, Ozono S, Sugiyama T, Takayama T, Sasaki T,Hirasawa N, Hiratsuka M.Biol Pharm Bull. 2016;39(10):1683-1686.PMID: 27725446 Free Article

Proposal of a Dukes-MAC-like staging system for gastric cancer.Gurzu S, Sugimura H, Orlowska J, Szederjesi J, Szentirmay Z, Bara T, Bara T Jr, Fetyko A, Jung I.J Investig Med. 2017 Feb;65(2):316-322. doi: 10.1136/jim-2016-000270. Epub 2016 Sep 15.PMID: 27634644

Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese.Kasai S, Nishizawa D, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K.Pharmacogenomics. 2016 Aug;17(13):1441-51. doi: 10.2217/pgs.15.184. Epub 2016 Aug 5.PMID: 27491383

Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somaticmutations via a reduction in the DNA repair capacity in prostate adenocarcinoma.Shinmura K, Kato H, Kawanishi Y, Yoshimura K, Igarashi H, Goto M, Tao H, Inoue Y, Sugiyama T, Furuse H,Ozono S, Sugimura H.Mol Carcinog. 2017 Feb;56(2):781-788. doi: 10.1002/mc.22509. Epub 2016 Jun 10.PMID: 27253753

Susceptibility to human cancer: From the perspective of a pathologist.Sugimura H.Pathol Int. 2016 Jul;66(7):359-68. doi: 10.1111/pin.12418. Epub 2016 May 23. Review.PMID: 27216305

Visualization of sphingolipids and phospholipids in the fundic gland mucosa of human stomach using imagingmass spectrometry.Kurabe N, Igarashi H, Ohnishi I, Tajima S, Inoue Y, Takahashi Y, Setou M, Sugimura H.World J Gastrointest Pathophysiol. 2016 May 15;7(2):235-41. doi: 10.4291/wjgp.v7.i2.235.PMID: 27190696 Free PMC Article

Clinical significance of PD-L1 and PD-L2 copy number gains in non-small-cell lung cancer.Inoue Y, Yoshimura K, Mori K, Kurabe N, Kahyo T, Mori H, Kawase A, Tanahashi M, Ogawa H, Inui N, FunaiK, Shinmura K, Niwa H, Suda T, Sugimura H.Oncotarget. 2016 May 31;7(22):32113-28. doi: 10.18632/oncotarget.8528.PMID: 27050074 Free PMC Article

Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with SomaticMutation Loads in Human Cancer.Shinmura K, Kato H, Kawanishi Y, Igarashi H, Goto M, Tao H, Inoue Y, Nakamura S, Misawa K, Mineta H,Sugimura H.Oxid Med Cell Longev. 2016;2016:1546392. doi: 10.1155/2016/1546392. Epub 2016 Mar 3.PMID: 27042257 Free PMC Article

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Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs.Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao R, Hayashi M, Kai C, Matsuda A,Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T.Cancer Sci. 2016 Feb;107(2):189-202. doi: 10.1111/cas.12857. Review.PMID: 26919617 Free PMC Article

Genetic Polymorphisms of CYP2A6 in a Case-Control Study on Bladder Cancer in Japanese Smokers.Kumondai M, Hosono H, Orikasa K, Arai Y, Arai T, Sugimura H, Ozono S, Sugiyama T, Takayama T, Sasaki T,Hirasawa N, Hiratsuka M.Biol Pharm Bull. 2016;39(1):84-9. doi: 10.1248/bpb.b15-00604.PMID: 26725431 Free Article

Functional Evaluation of Nine Missense-Type Variants of the Human DNA Glycosylase Enzyme MUTYH in theJapanese Population.Shinmura K, Kato H, Goto M, Yamada H, Tao H, Nakamura S, Sugimura H.Hum Mutat. 2016 Apr;37(4):350-3. doi: 10.1002/humu.22949. Epub 2016 Jan 8.PMID: 26694661

Geographic particularities in incidence and etiopathogenesis of sporadic gastric cancer.Kadar Z, Jung I, Orlowska J, Szentirmay Z, Sugimura H, Turdean S, Simona G.Pol J Pathol. 2015 Sep;66(3):254-9.PMID: 26619104 Free Article

Clinicopathological and Survival Analysis of Japanese Patients with Resected Non-Small-Cell Lung CancerHarboring NKX2-1, SETDB1, MET, HER2, SOX2, FGFR1, or PIK3CA Gene Amplification.Inoue Y, Matsuura S, Kurabe N, Kahyo T, Mori H, Kawase A, Karayama M, Inui N, Funai K, Shinmura K, SudaT, Sugimura H.J Thorac Oncol. 2015 Nov;10(11):1590-600. doi: 10.1097/JTO.0000000000000685.PMID: 26536195 Free Article

New Insights in Histogenetic Pathways of Gastric Cancer.Gurzu S, Sugimura H, Orlowska J, Szentirmay Z, Jung I.Medicine (Baltimore). 2015 Oct;94(42):e1810. doi: 10.1097/MD.0000000000001810.PMID: 26496316 Free PMC Article

Single skip metastasis in sentinel lymph node: In an early gastric cancer.Bara T Jr, Gurzu S, Jung I, Kadar Z, Sugimura H, Bara T.World J Gastroenterol. 2015 Sep 7;21(33):9803-7. doi: 10.3748/wjg.v21.i33.9803.PMID: 26361428 Free PMC Article

The inner centromere-shugoshin network prevents chromosomal instability.Tanno Y, Susumu H, Kawamura M, Sugimura H, Honda T, Watanabe Y.Science. 2015 Sep 11;349(6253):1237-40. doi: 10.1126/science.aaa2655. Retraction in: Science. 2017 Sep 8;357(6355):981.PMID: 26359403 Free Article

Uterine Angiosarcoma: A Case Report and Literature Review.Liu Y, Guo S, Wang L, Suzuki S, Sugimura H, Li Y.Int J Gynecol Pathol. 2016 May;35(3):264-8. doi: 10.1097/PGP.0000000000000219. Review.PMID: 26352549

Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H.Sci Rep. 2015 Aug 27;5:13474. doi: 10.1038/srep13474.PMID: 26310847 Free PMC Article

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Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotinedependence in genome-wide and subsequent association studies.Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, TagamiM, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, YamadaY, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M,Sugimura H, Ikeda K.Mol Brain. 2015 Aug 20;8:50. doi: 10.1186/s13041-015-0142-x.PMID: 26289589 Free PMC Article

Hereditary diffuse gastric cancer--An overview.Gurzu S, Jung I, Orlowska J, Sugimura H, Kadar Z, Turdean S, Bara T Jr.Pathol Res Pract. 2015 Sep;211(9):629-32. doi: 10.1016/j.prp.2015.06.003. Epub 2015 Jun 11. Review.PMID: 26150395

Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference toCancer Susceptibility.Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K, Dobashi Y.Biomed Res Int. 2015;2015:316829. doi: 10.1155/2015/316829. Epub 2015 Jun 7.PMID: 26137473 Free PMC Article

Validity of Tissue Microarray by Immunohistochemistry.Fujita H, Takayama T, Takaoka N, Tan C, Igarashi H, Sugimura H, Ozono S.Clin Lab. 2015;61(5-6):569-74.PMID: 26118190

NEIL1 p.Gln282Stop variant is predominantly localized in the cytoplasm and exhibits reduced activity insuppressing mutations.Shinmura K, Kato H, Kawanishi Y, Goto M, Tao H, Inoue Y, Nakamura S, Sugimura H.Gene. 2015 Oct 15;571(1):33-42. doi: 10.1016/j.gene.2015.06.043. Epub 2015 Jun 19.PMID: 26095805

CYP2A6 genetic polymorphism is associated with decreased susceptibility to squamous cell lung cancer inJapanese smokers.Hosono H, Kumondai M, Arai T, Sugimura H, Sasaki T, Hirasawa N, Hiratsuka M.Drug Metab Pharmacokinet. 2015 Aug;30(4):263-8. doi: 10.1016/j.dmpk.2015.04.002. Epub 2015 Apr 18.PMID: 26091970

BSND and ATP6V1G3: Novel Immunohistochemical Markers for Chromophobe Renal Cell Carcinoma.Shinmura K, Igarashi H, Kato H, Koda K, Ogawa H, Takahashi S, Otsuki Y, Yoneda T, Kawanishi Y, Funai K,Takayama T, Ozono S, Sugimura H.Medicine (Baltimore). 2015 Jun;94(24):e989. doi: 10.1097/MD.0000000000000989.PMID: 26091477 Free PMC Article

Maspin-related Orchestration of Aggressiveness of Gastric Cancer.Gurzu S, Kadar Z, Sugimura H, Orlowska J, Bara T, Bara T Jr, Szederjesi J, Jung I.Appl Immunohistochem Mol Morphol. 2016 May-Jun;24(5):326-36. doi: 10.1097/PAI.0000000000000189.PMID: 26067133

SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patientswith colorectal cancer.Shinmura K, Kato H, Kawanishi Y, Nagura K, Kamo T, Okubo Y, Inoue Y, Kurabe N, Du C, Iwaizumi M,Kurachi K, Nakamura T, Sugimura H.Oncol Rep. 2015 Aug;34(2):727-38. doi: 10.3892/or.2015.4014. Epub 2015 May 28.

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Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene:A Case Report and Literature Review.Kuroda S, Suzuki S, Kurita A, Muraki M, Aoshima Y, Tanioka F, Sugimura H.Case Rep Pathol. 2015;2015:572951. doi: 10.1155/2015/572951. Epub 2015 Jan 19.PMID: 25685583 Free PMC Article

CD44-SLC1A2 fusion transcripts in primary colorectal cancer.Shinmura K, Kato H, Igarashi H, Inoue Y, Nakamura S, Du C, Kurachi K, Nakamura T, Ogawa H, TanahashiM, Niwa H, Sugimura H.Pathol Oncol Res. 2015 Jul;21(3):759-64. doi: 10.1007/s12253-014-9887-2. Epub 2015 Jan 10.PMID: 25576211

Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena proteinreactivity.Gurzu S, Kadar Z, Sugimura H, Bara T, Bara T Jr, Halmaciu I, Jung I.APMIS. 2015 Mar;123(3):223-33. doi: 10.1111/apm.12347. Epub 2014 Dec 31.PMID: 25556597

A novel APC mosaicism in a patient with familial adenomatous polyposis.Iwaizumi M, Tao H, Yamaguchi K, Yamada H, Shinmura K, Kahyo T, Yamanaka Y, Kurachi K, Sugimoto K,Furukawa Y, Sugimura H.Hum Genome Var. 2015 Dec 10;2:15057. doi: 10.1038/hgv.2015.57. eCollection 2015.PMID: 27081559 Free PMC Article

CLCA2 as a novel immunohistochemical marker for differential diagnosis of squamous cell carcinoma fromadenocarcinoma of the lung.Shinmura K, Igarashi H, Kato H, Kawanishi Y, Inoue Y, Nakamura S, Ogawa H, Yamashita T, Kawase A, FunaiK, Sugimura H.Dis Markers. 2014;2014:619273. doi: 10.1155/2014/619273. Epub 2014 Dec 7.PMID: 25548429 Free PMC Article

NSD3-NUT-expressing midline carcinoma of the lung: first characterization of primary cancer tissue.Suzuki S, Kurabe N, Ohnishi I, Yasuda K, Aoshima Y, Naito M, Tanioka F, Sugimura H.Pathol Res Pract. 2015 May;211(5):404-8. doi: 10.1016/j.prp.2014.10.013. Epub 2014 Nov 13.PMID: 25466466

Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and post-operative analgesia, painsensitivity, and nicotine dependence.Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, HayashidaM, Ikeda K.J Pharmacol Sci. 2014;126(3):253-63. Epub 2014 Oct 25.PMID: 25346042 Free Article

Extensive goblet cell metaplasia of the peripheral lung may harbor precancerous molecular changes:comparison of two cases.Tajima S, Kurabe N, Okudela K, Yajima K, Takahashi T, Neyatani H, Sugimura H, Koda K.Pathol Int. 2014 Oct;64(10):533-8. doi: 10.1111/pin.12204. Epub 2014 Sep 17.PMID: 25229323

Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts.Goto M, Shinmura K, Matsushima Y, Ishino K, Yamada H, Totsuka Y, Matsuda T, Nakagama H, Sugimura H.Free Radic Biol Med. 2014 Nov;76:136-46. doi: 10.1016/j.freeradbiomed.2014.07.044. Epub 2014 Aug 20.

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Robust quantitative assessments of cytosine modifications and changes in the expressions of relatedenzymes in gastric cancer.Du C, Kurabe N, Matsushima Y, Suzuki M, Kahyo T, Ohnishi I, Tanioka F, Tajima S, Goto M, Yamada H, TaoH, Shinmura K, Konno H, Sugimura H.Gastric Cancer. 2015 Jul;18(3):516-25. doi: 10.1007/s10120-014-0409-4. Epub 2014 Aug 7.PMID: 25098926

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastriccancer.Shinmura K, Kurabe N, Goto M, Yamada H, Natsume H, Konno H, Sugimura H.Mol Biol Rep. 2014 Oct;41(10):6635-44. doi: 10.1007/s11033-014-3546-2. Epub 2014 Jul 1.PMID: 24981932

Radiation-induced breast angiosarcoma with a confirmative feature of c-MYC amplification.Tajima S, Mochizuki R, Sugimura H, Hoshi S.Jpn J Clin Oncol. 2014 Jul;44(7):702-3. doi: 10.1093/jjco/hyu064. Epub 2014 Jun 5. No abstract available.PMID: 24903854

RSPO fusion transcripts in colorectal cancer in Japanese population.Shinmura K, Kahyo T, Kato H, Igarashi H, Matsuura S, Nakamura S, Kurachi K, Nakamura T, Ogawa H, FunaiK, Tanahashi M, Niwa H, Sugimura H.Mol Biol Rep. 2014 Aug;41(8):5375-84. doi: 10.1007/s11033-014-3409-x. Epub 2014 May 22.PMID: 24847761

Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient withearly-onset colorectal cancer.Shinmura K, Goto M, Tao H, Kato H, Suzuki R, Nakamura S, Matsuda T, Yin G, Morita M, Kono S, SugimuraH.Oxid Med Cell Longev. 2014;2014:617351. doi: 10.1155/2014/617351. Epub 2014 Mar 23.PMID: 24799981 Free PMC Article

YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers.Harada M, Kotake Y, Ohhata T, Kitagawa K, Niida H, Matsuura S, Funai K, Sugimura H, Suda T, Kitagawa M.Genes Cells. 2014 Jun;19(6):504-16. doi: 10.1111/gtc.12150. Epub 2014 Apr 29.PMID: 24774443 Free Article

A rare Japanese case with a NUT midline carcinoma in the nasal cavity: a case report withimmunohistochemical and genetic analyses.Suzuki S, Kurabe N, Minato H, Ohkubo A, Ohnishi I, Tanioka F, Sugimura H.Pathol Res Pract. 2014 Jun;210(6):383-8. doi: 10.1016/j.prp.2014.01.013. Epub 2014 Feb 22.PMID: 24655834

An autopsy case of malignant pleural mesothelioma associated with nephrotic syndrome.Suzuki S, Toyoshima M, Nihashi F, Tsukui H, Baba S, Sugimura H, Suda T.Intern Med. 2014;53(3):243-6. Review.PMID: 24492694 Free Article

A novel somatic FGFR3 mutation in primary lung cancer.Shinmura K, Kato H, Matsuura S, Inoue Y, Igarashi H, Nagura K, Nakamura S, Maruyama K, Tajima M, FunaiK, Ogawa H, Tanahashi M, Niwa H, Sugimura H.Oncol Rep. 2014 Mar;31(3):1219-24. doi: 10.3892/or.2014.2984. Epub 2014 Jan 20.PMID: 24452392

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TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer.Shinmura K, Kiyose S, Nagura K, Igarashi H, Inoue Y, Nakamura S, Maeda M, Baba M, Konno H, SugimuraH.J Surg Oncol. 2014 Mar;109(3):189-97. doi: 10.1002/jso.23482. Epub 2013 Oct 31.PMID: 24178904

Establishment and characterization of a mutagenized cell line exhibiting the 'cell-in-cell' phenotype at a highfrequency.Kahyo T, Sugimura H.Genes Cells. 2013 Nov;18(11):1042-52. doi: 10.1111/gtc.12092. Epub 2013 Sep 24.PMID: 24165024 Free Article

SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers.Matsuura S, Kahyo T, Shinmura K, Iwaizumi M, Yamada H, Funai K, Kobayashi J, Tanahashi M, Niwa H,Ogawa H, Takahashi T, Inui N, Suda T, Chida K, Watanabe Y, Sugimura H.Sci Rep. 2013 Oct 22;3:3012. doi: 10.1038/srep03012.PMID: 24146025 Free PMC Article

Breakages at YWHAE, FAM22A, and FAM22B loci in uterine angiosarcoma: a case report withimmunohistochemical and genetic analysis.Suzuki S, Tanioka F, Minato H, Ayhan A, Kasami M, Sugimura H.Pathol Res Pract. 2014 Feb;210(2):130-4. doi: 10.1016/j.prp.2013.09.009. Epub 2013 Sep 26.PMID: 24125656

CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma.Matsuura S, Shinmura K, Kamo T, Igarashi H, Maruyama K, Tajima M, Ogawa H, Tanahashi M, Niwa H, FunaiK, Kohno T, Suda T, Sugimura H.Oncol Rep. 2013 Oct;30(4):1675-80. doi: 10.3892/or.2013.2630. Epub 2013 Jul 19.PMID: 23877438

Identification and association study with lung cancer for novel insertion polymorphisms of human endogenousretrovirus.Kahyo T, Tao H, Shinmura K, Yamada H, Mori H, Funai K, Kurabe N, Suzuki M, Tanahashi M, Niwa H, OgawaH, Tanioka F, Yin G, Morita M, Matsuo K, Kono S, Sugimura H.Carcinogenesis. 2013 Nov;34(11):2531-8. doi: 10.1093/carcin/bgt253. Epub 2013 Jul 19.PMID: 23872666

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.Kurabe N, Hayasaka T, Ogawa M, Masaki N, Ide Y, Waki M, Nakamura T, Kurachi K, Kahyo T, Shinmura K,Midorikawa Y, Sugiyama Y, Setou M, Sugimura H.Cancer Sci. 2013 Oct;104(10):1295-302. doi: 10.1111/cas.12221. Epub 2013 Jul 30.PMID: 23815430 Free Article

Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene.Sugimoto S, Yamada H, Takahashi M, Morohoshi Y, Yamaguchi N, Tsunoda Y, Hayashi H, Sugimura H,Komatsu H.Gastric Cancer. 2014 Oct;17(4):745-9. doi: 10.1007/s10120-013-0278-2. Epub 2013 Jun 29.PMID: 23812922 Free PMC Article

D2-40-positive lymphatic vessel invasion is not a poor prognostic factor in stage I lung adenocarcinoma.Shimizu K, Funai K, Sugimura H, Sekihara K, Kawase A, Shiiya N.Pathol Int. 2013 Apr;63(4):201-5. doi: 10.1111/pin.12048.PMID: 23692420

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Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung usingimaging mass spectrometry.Kurabe N, Hayasaka T, Igarashi H, Mori H, Sekihara K, Tao H, Yamada H, Kahyo T, Onishi I, Tsukui H,Kawase A, Matsuura S, Inoue Y, Shinmura K, Funai K, Setou M, Sugimura H.Pathol Int. 2013 Apr;63(4):195-200. doi: 10.1111/pin.12050.PMID: 23692419

[Genome-wide association study identified susceptibility loci associated with nicotine dependence in aJapanese population].Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K.Nihon Shinkei Seishin Yakurigaku Zasshi. 2013 Apr;33(2):77-9. Japanese. No abstract available.PMID: 25314744

Editorial: an obsession with subtyping gastric cancer.Sugimura H.Gastric Cancer. 2013 Oct;16(4):451-3. doi: 10.1007/s10120-013-0243-0. No abstract available.PMID: 23483302

[Familial gastric cancer - an update of Japanese cases].Sugimura H, Yamada H, Tao H, Shinmura K, Iwaizumi M, Kasami M.Gan To Kagaku Ryoho. 2013 Feb;40(2):154-8. Review. Japanese.PMID: 23411952

Internal frontier: the pathophysiology of the small intestine.Sugimura H, Osawa S.World J Gastroenterol. 2013 Jan 14;19(2):161-4. doi: 10.3748/wjg.v19.i2.161.PMID: 23345938 Free PMC Article

Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis.Shinmura K, Goto M, Tao H, Matsuura S, Matsuda T, Sugimura H.World J Gastroenterol. 2012 Dec 21;18(47):6935-42. doi: 10.3748/wjg.v18.i47.6935.PMID: 23322991 Free PMC Article

Hepatocellular adenoma associated with familial adenomatous polyposis coli.Inaba K, Sakaguchi T, Kurachi K, Mori H, Tao H, Nakamura T, Takehara Y, Baba S, Maekawa M, Sugimura H,Konno H.World J Hepatol. 2012 Nov 27;4(11):322-6. doi: 10.4254/wjh.v4.i11.322.PMID: 23293720 Free PMC Article

Chromogenic in situ hybridization (CISH) to detect HER2 gene amplification in breast and gastric cancer:comparison with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH).Kiyose S, Igarashi H, Nagura K, Kamo T, Kawane K, Mori H, Ozawa T, Maeda M, Konno K, Hoshino H, KonnoH, Ogura H, Shinmura K, Hattori N, Sugimura H.Pathol Int. 2012 Nov;62(11):728-34. doi: 10.1111/j.1440-1827.2012.02862.x.PMID: 23121603

Lipid peroxidation-induced DNA adducts in human gastric mucosa.Matsuda T, Tao H, Goto M, Yamada H, Suzuki M, Wu Y, Xiao N, He Q, Guo W, Cai Z, Kurabe N, Ishino K,Matsushima Y, Shinmura K, Konno H, Maekawa M, Wang Y, Sugimura H.Carcinogenesis. 2013 Jan;34(1):121-7. doi: 10.1093/carcin/bgs327. Epub 2012 Oct 11.PMID: 23066087

How can research fields be integrated with PET imaging?Sugimura H.

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Gastric Cancer. 2013 Apr;16(2):118-9. doi: 10.1007/s10120-012-0177-y. No abstract available. Erratum in: Gastric Cancer. 2013Apr;16(2):120.PMID: 22806417

Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization.Kiyose S, Nagura K, Tao H, Igarashi H, Yamada H, Goto M, Maeda M, Kurabe N, Suzuki M, Tsuboi M, KahyoT, Shinmura K, Hattori N, Sugimura H.Pathol Int. 2012 Jul;62(7):477-84. doi: 10.1111/j.1440-1827.2012.02832.x.PMID: 22691185

The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target ingastric cancer.Natsume H, Shinmura K, Tao H, Igarashi H, Suzuki M, Nagura K, Goto M, Yamada H, Maeda M, Konno H,Nakamura S, Sugimura H.J Transl Med. 2012 Jul 3;10:97. doi: 10.1186/1479-5876-10-97.PMID: 22591714 Free PMC Article

Association between dopamine beta hydroxylase rs5320 polymorphism and smoking behaviour in elderlyJapanese.Ella E, Sato N, Nishizawa D, Kageyama S, Yamada H, Kurabe N, Ishino K, Tao H, Tanioka F, Nozawa A,Renyin C, Shinmura K, Ikeda K, Sugimura H.J Hum Genet. 2012 Jun;57(6):385-90. doi: 10.1038/jhg.2012.40. Epub 2012 Apr 19.PMID: 22513716

[Benign or malignant non-epithelial tumor].Arai T, Aida J, Takubo K, Sugimura H, Baba S.Nihon Rinsho. 2011 Aug;69 Suppl 6:93-8. Review. Japanese. No abstract available.PMID: 22471002

Endobronchial metastasis from gastrinoma of the pancreas.Toyoshima M, Chida K, Suda T, Sugimura H, Sato M.Am J Respir Crit Care Med. 2012 Mar 1;185(5):590-1. No abstract available.PMID: 22383575

Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is anovel predictor of a poor prognosis in human gastric cancer.Shinmura K, Goto M, Suzuki M, Tao H, Yamada H, Igarashi H, Matsuura S, Maeda M, Konno H, Matsuda T,Sugimura H.J Pathol. 2011 Nov;225(3):414-23. doi: 10.1002/path.2953. Epub 2011 Aug 8.PMID: 21826668

Association between cancer risk and drug-metabolizing enzyme gene (CYP2A6, CYP2A13, CYP4B1,SULT1A1, GSTM1, and GSTT1) polymorphisms in cases of lung cancer in Japan.Tamaki Y, Arai T, Sugimura H, Sasaki T, Honda M, Muroi Y, Matsubara Y, Kanno S, Ishikawa M, Hirasawa N,Hiratsuka M.Drug Metab Pharmacokinet. 2011;26(5):516-22. Epub 2011 Jul 26.PMID: 21791872 Free Article

Germline alterations in the CDH1 gene in familial gastric cancer in the Japanese population.Yamada H, Shinmura K, Ito H, Kasami M, Sasaki N, Shima H, Ikeda M, Tao H, Goto M, Ozawa T, TsuneyoshiT, Tanioka F, Sugimura H.Cancer Sci. 2011 Oct;102(10):1782-8. doi: 10.1111/j.1349-7006.2011.02038.x. Epub 2011 Aug 19.PMID: 21777349 Free Article

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Genetic susceptibility to lung cancer.Sugimura H, Tao H, Suzuki M, Mori H, Tsuboi M, Matsuura S, Goto M, Shinmura K, Ozawa T, Tanioka F, SatoN, Matsushima Y, Kageyama S, Funai K, Chou PH, Matsuda T.Front Biosci (Schol Ed). 2011 Jun 1;3:1463-77. Review.PMID: 21622282

Novel single nucleotide polymorphism of the CYP2A13 gene in Japanese individuals.Tamaki Y, Honda M, Muroi Y, Arai T, Sugimura H, Matsubara Y, Kanno S, Ishikawa M, Hirasawa N, HiratsukaM.Drug Metab Pharmacokinet. 2011;26(5):544-7. Epub 2011 May 24.PMID: 21606606 Free Article

The 7th Asia Cancer Forum: from the perspective of human security, how can we collaborate as Asians inorder to place cancer on the global health agenda? How can we fill in the gaps that exist among us?Kawahara N, Roh JK, Akaza H, Inoue H, Shibuya K, Iwasaki M, Tsuji T, Nishiyama M, Nakagawara A,Watanabe K, Nozaki S, Inoue M, Sugimura H, Miyake J, Li F.Jpn J Clin Oncol. 2011 Jun;41(6):825-31. doi: 10.1093/jjco/hyr052. Epub 2011 Apr 28.PMID: 21531734

Lymphatic vessel invasion is a significant prognostic indicator in stage IA lung adenocarcinoma.Funai K, Sugimura H, Morita T, Shundo Y, Shimizu K, Shiiya N.Ann Surg Oncol. 2011 Oct;18(10):2968-72. doi: 10.1245/s10434-011-1729-9. Epub 2011 Apr 22.PMID: 21512862

The 6th Asia cancer forum: what should we do to place cancer on the global health agenda? Sharinginformation leads to human security.Kawahara N, Sugimura H, Nakagawara A, Masui T, Miyake J, Akiyama M, Wahid IA, Hao X, Akaza H.Jpn J Clin Oncol. 2011 May;41(5):723-9. doi: 10.1093/jjco/hyr036. Epub 2011 Mar 29.PMID: 21450718

Metachronous multiple adenocarcinomas of the pancreas.Ikematsu Y, Tamura H, Nakata Y, Hayashi T, Kanai T, Hirayama K, Mori H, Ozawa T, Hasegawa S, OkawadaT, Kageyama S, Sugimura H, Nishiwaki Y.Int J Clin Oncol. 2011 Dec;16(6):726-31. doi: 10.1007/s10147-011-0206-6. Epub 2011 Mar 3.PMID: 21365362

Aberrant expression and mutation-inducing activity of AID in human lung cancer.Shinmura K, Igarashi H, Goto M, Tao H, Yamada H, Matsuura S, Tajima M, Matsuda T, Yamane A, Funai K,Tanahashi M, Niwa H, Ogawa H, Sugimura H.Ann Surg Oncol. 2011 Jul;18(7):2084-92. doi: 10.1245/s10434-011-1568-8. Epub 2011 Feb 3.PMID: 21290192

Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinalstromal tumors.Setoguchi T, Kikuchi H, Yamamoto M, Baba M, Ohta M, Kamiya K, Tanaka T, Baba S, Goto-Inoue N, Setou M,Sasaki T, Mori H, Sugimura H, Konno H.Cancer Sci. 2011 Apr;102(4):883-9. doi: 10.1111/j.1349-7006.2011.01872.x. Epub 2011 Feb 24.PMID: 21244575 Free Article

EPH-EPHRIN in human gastrointestinal cancers.Sugimura H, Wang JD, Mori H, Tsuboi M, Nagura K, Igarashi H, Tao H, Nakamura R, Natsume H, Kahyo T,Shinmura K, Konno H, Hamaya Y, Kanaoka S, Kataoka H, Zhou XJ.World J Gastrointest Oncol. 2010 Dec 15;2(12):421-8. doi: 10.4251/wjgo.v2.i12.421.PMID: 21191536 Free PMC Article

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Three novel NEIL1 promoter polymorphisms in gastric cancer patients.Goto M, Shinmura K, Tao H, Tsugane S, Sugimura H.World J Gastrointest Oncol. 2010 Feb 15;2(2):117-20. doi: 10.4251/wjgo.v2.i2.117.PMID: 21160930 Free PMC Article

Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanesepatients with classical and attenuated familial adenomatous polyposis.Tao H, Shinmura K, Yamada H, Maekawa M, Osawa S, Takayanagi Y, Okamoto K, Terai T, Mori H, NakamuraT, Sugimura H.BMC Res Notes. 2010 Nov 16;3:305. doi: 10.1186/1756-0500-3-305.PMID: 21078199 Free PMC Article

A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility todiffuse-type gastric cancer.Saeki N, Saito A, Choi IJ, Matsuo K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee YS, Yoon KA, Kook MC,Park SR, Kim YW, Tanaka H, Tajima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, Kato S, Nakamura T,Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagihara K, Katai H, Shimoda T, Yoshida T, Nakamura Y, HirohashiS, Sakamoto H.Gastroenterology. 2011 Mar;140(3):892-902. doi: 10.1053/j.gastro.2010.10.058. Epub 2010 Nov 8.PMID: 21070779

Expression of EphA1 in gastric carcinomas is associated with metastasis and survival.Wang J, Dong Y, Wang X, Ma H, Sheng Z, Li G, Lu G, Sugimura H, Zhou X.Oncol Rep. 2010 Dec;24(6):1577-84.PMID: 21042754

Detection of lipid peroxidation-induced DNA adducts caused by 4-oxo-2(E)-nonenal and 4-oxo-2(E)-hexenalin human autopsy tissues.Chou PH, Kageyama S, Matsuda S, Kanemoto K, Sasada Y, Oka M, Shinmura K, Mori H, Kawai K, Kasai H,Sugimura H, Matsuda T.Chem Res Toxicol. 2010 Sep 20;23(9):1442-8. doi: 10.1021/tx100047d.PMID: 20849149

Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patientswith colorectal polyposis and cancer.Goto M, Shinmura K, Nakabeppu Y, Tao H, Yamada H, Tsuneyoshi T, Sugimura H.Hum Mutat. 2010 Nov;31(11):E1861-74. doi: 10.1002/humu.21363.PMID: 20848659 Free PMC Article

Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese.Sato N, Kageyama S, Chen R, Suzuki M, Mori H, Tanioka F, Yamada H, Kamo T, Tao H, Shinmura K, NozawaA, Sugimura H.J Hum Genet. 2010 Nov;55(11):755-60. doi: 10.1038/jhg.2010.108. Epub 2010 Sep 2.PMID: 20811389

Assessment of cumulative evidence for the association between glutathione S-transferase polymorphismsand lung cancer: application of the Venice interim guidelines.Langevin SM, Ioannidis JP, Vineis P, Taioli E; Genetic Susceptibility to Environmental Carcinogens group(GSEC).Pharmacogenet Genomics. 2010 Oct;20(10):586-97. doi: 10.1097/FPC.0b013e32833c3892.PMID: 20729793 Free PMC Article

SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity throughDeacetylation of Specific Lysine Residues in Mammals.

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Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y,Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV,Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M.PLoS One. 2010 Jul 23;5(7):e11755. doi: 10.1371/journal.pone.0011755.PMID: 20668706 Free PMC Article

Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin inHelicobacter pylori-negative healthy volunteers.Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, HishidaA, Furuta T.J Clin Pharmacol. 2011 Jul;51(7):1079-86. doi: 10.1177/0091270010376194. Epub 2010 Jul 27.PMID: 20663999

Fluorescence in situ hybridization analysis with a tissue microarray: 'FISH and chips' analysis of pathologyarchives.Sugimura H, Mori H, Nagura K, Kiyose S, Tao H, Isozaki M, Igarashi H, Shinmura K, Hasegawa A, KitayamaY, Tanioka F.Pathol Int. 2010 Aug;60(8):543-50. doi: 10.1111/j.1440-1827.2010.02561.x. Review. Erratum in: Pathol Int. 2010 Sep;60(9):650.Hong, Tao [corrected to Tao, Hong].PMID: 20618731

IgG4-related lung disease in a worker occupationally exposed to asbestos.Toyoshima M, Chida K, Kono M, Kaida Y, Nakamura Y, Suda T, Sugimura H.Intern Med. 2010;49(12):1175-8. Epub 2010 Jun 15.PMID: 20558938 Free Article

Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1AmRNA expression in non-small cell lung carcinoma.Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T, Suzuki K, Tanahashi M, Niwa H, Ogawa H,Sugimura H.Lung Cancer. 2011 Jan;71(1):19-27. doi: 10.1016/j.lungcan.2010.04.006.PMID: 20434789

Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese.Sato N, Kageyama S, Chen R, Suzuki M, Tanioka F, Kamo T, Shinmura K, Nozawa A, Sugimura H.Psychiatr Genet. 2010 Jun;20(3):135-6. doi: 10.1097/YPG.0b013e32833a21f9. No abstract available.PMID: 20414139

EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas.Shinmura K, Kageyama S, Igarashi H, Kamo T, Mochizuki T, Suzuki K, Tanahashi M, Niwa H, Ogawa H,Sugimura H.Exp Ther Med. 2010 Mar;1(2):271-275. Epub 2010 Mar 1.PMID: 22993539 Free PMC Article

Rare form of extraovarian peritoneal serous papillary carcinoma with solitary tumor in the abdominal wall: acase report and literature review.Matsuura T, Sugihara K, Kohmura Y, Sugimura H, Kanayama N.J Obstet Gynaecol Res. 2009 Dec;35(6):1142-7. doi: 10.1111/j.1447-0756.2009.01074.x.PMID: 20144179

Secreted form of EphA7 in lung cancer.Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H, Niwa H, Shinmura K,Sugimura H.Int J Oncol. 2010 Mar;36(3):635-40.

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Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray.Morita Y, Ikegami K, Goto-Inoue N, Hayasaka T, Zaima N, Tanaka H, Uehara T, Setoguchi T, Sakaguchi T,Igarashi H, Sugimura H, Setou M, Konno H.Cancer Sci. 2010 Jan;101(1):267-73. doi: 10.1111/j.1349-7006.2009.01384.x. Epub 2009 Oct 8.PMID: 19961487 Free Article

Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole.Sugimoto M, Nishino M, Kodaira C, Yamade M, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T.J Clin Pharmacol. 2010 Mar;50(3):320-30. doi: 10.1177/0091270009344983. Epub 2009 Nov 25.PMID: 19940233

Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role incarcinogenesis.Okudela K, Yazawa T, Ishii J, Woo T, Mitsui H, Bunai T, Sakaeda M, Shimoyamada H, Sato H, Tajiri M, OgawaN, Masuda M, Sugimura H, Kitamura H.Am J Pathol. 2009 Dec;175(6):2646-56. doi: 10.2353/ajpath.2009.080571. Epub 2009 Nov 5. Erratum in: Am J Pathol. 2010May;176(5):2581.PMID: 19893046 Free PMC Article

Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthyvolunteers.Nishino M, Sugimoto M, Kodaira C, Yamade M, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, FurutaT.Dig Dis Sci. 2010 Jun;55(6):1627-36. doi: 10.1007/s10620-009-0920-3. Epub 2009 Aug 12.PMID: 19672708

Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients.Yamada H, Shinmura K, Goto M, Iwaizumi M, Konno H, Kataoka H, Yamada M, Ozawa T, Tsuneyoshi T,Tanioka F, Sugimura H.Mol Cancer. 2009 Aug 12;8:63. doi: 10.1186/1476-4598-8-63.PMID: 19671196 Free PMC Article

Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis.Okudela K, Yazawa T, Woo T, Sakaeda M, Ishii J, Mitsui H, Shimoyamada H, Sato H, Tajiri M, Ogawa N,Masuda M, Takahashi T, Sugimura H, Kitamura H.Am J Pathol. 2009 Aug;175(2):867-81. doi: 10.2353/ajpath.2009.080489. Epub 2009 Jul 16.PMID: 19608870 Free PMC Article

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H,Gemma A, Kudoh S, Croce CM, Harris CC.Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12085-90. doi: 10.1073/pnas.0905234106. Epub 2009 Jul 13.PMID: 19597153 Free PMC Article

Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancerscreening.Takai T, Kanaoka S, Yoshida K, Hamaya Y, Ikuma M, Miura N, Sugimura H, Kajimura M, Hishida A.Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1888-93. doi: 10.1158/1055-9965.EPI-08-0937.PMID: 19505922 Free Article

Altered expression of the human base excision repair gene NTH1 in gastric cancer.Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, Iwaizumi M, Kageyama S, Tsuneyoshi

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T, Tsugane S, Sugimura H.Carcinogenesis. 2009 Aug;30(8):1345-52. doi: 10.1093/carcin/bgp108. Epub 2009 May 4.PMID: 19414504

Identification and characterization of a novel germline p53 mutation in a patient with glioblastoma and coloncancer.Yamada H, Shinmura K, Yamamura Y, Kurachi K, Nakamura T, Tsuneyoshi T, Yokota N, Maekawa M,Sugimura H.Int J Cancer. 2009 Aug 15;125(4):973-6. doi: 10.1002/ijc.24432.PMID: 19405127 Free Article

Copy number estimation algorithms and fluorescence in situ hybridization to describe copy number alterationsin human tumors.Suzuki M, Nagura K, Igarashi H, Tao H, Midorikawa Y, Kitayama Y, Sugimura H.Pathol Int. 2009 Apr;59(4):218-28. doi: 10.1111/j.1440-1827.2009.02354.x.PMID: 19351364

Role of 3'-phosphoinositides in oncogenic KRAS-induced modulation of shape and motility of airway epithelialcells.Okudela K, Yazawa T, Suzuki T, Sugimura H, Kitamura H.Pathol Int. 2009 Jan;59(1):28-37. doi: 10.1111/j.1440-1827.2008.02321.x.PMID: 19121089

Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis.Midorikawa Y, Yamamoto S, Tsuji S, Kamimura N, Ishikawa S, Igarashi H, Makuuchi M, Kokudo N, SugimuraH, Aburatani H.Hepatology. 2009 Feb;49(2):513-22. doi: 10.1002/hep.22698.PMID: 19105209

Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis.Dong Y, Wang J, Sheng Z, Li G, Ma H, Wang X, Zhang R, Lu G, Hu Q, Sugimura H, Zhou X.Mod Pathol. 2009 Jan;22(1):151-60. doi: 10.1038/modpathol.2008.188. Epub 2008 Nov 14.PMID: 19011600 Free Article

Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to andprogression of gastric cancer in Japan.Sugimoto M, Furuta T, Kodaira C, Nishino M, Yamade M, Ikuma M, Sugimura H, Hishida A.J Gastroenterol. 2008;43(10):751-61. doi: 10.1007/s00535-008-2221-6. Epub 2008 Oct 29.PMID: 18958543

EphB1 is underexpressed in poorly differentiated colorectal cancers.Sheng Z, Wang J, Dong Y, Ma H, Zhou H, Sugimura H, Lu G, Zhou X.Pathobiology. 2008;75(5):274-80. doi: 10.1159/000151707. Epub 2008 Oct 15.PMID: 18931529

Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patient.Shinmura K, Suzuki M, Yamada H, Tao H, Goto M, Kamo T, Nagura K, Kageyama S, Kato M, Ogawa S,Maekawa M, Takamochi K, Suzuki K, Nakamura T, Sugimura H.Pathol Int. 2008 Nov;58(11):706-12. doi: 10.1111/j.1440-1827.2008.02297.x.PMID: 18844936

Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis.Yamagata N, Furuno K, Sonoda M, Sugimura H, Yamamoto K.

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Biochem Biophys Res Commun. 2008 Nov 21;376(3):499-503. doi: 10.1016/j.bbrc.2008.09.013. Epub 2008 Sep 13.PMID: 18793616

OGG1, MYH and MTH1 gene variants identified in gastric cancer patients exhibiting both 8-hydroxy-2'-deoxyguanosine accumulation and low inflammatory cell infiltration in their gastric mucosa.Goto M, Shinmura K, Yamada H, Tsuneyoshi T, Sugimura H.J Genet. 2008 Aug;87(2):181-6. No abstract available.PMID: 18776649 Free Article

Malignant pheochromocytoma in a young adult forming the structure simulating Homer Wright rosette:differentiation from neuroblastoma on repeating fluorescence in situ hybridization.Mori H, Nagata M, Nishijima N, Nagura K, Igarashi H, Hamazaki M, Ozono S, Sugimura H.Pathol Int. 2008 Aug;58(8):518-23. doi: 10.1111/j.1440-1827.2008.02266.x.PMID: 18705773

Inverse relationship between the length of the EGFR CA repeat polymorphism in lung carcinoma and proteinexpression of EGFR in the carcinoma.Suzuki M, Kageyama S, Shinmura K, Okudela K, Bunai T, Nagura K, Igarashi H, Kiyose S, Mori H, Tao H,Goto M, Takamochi K, Mochizuki T, Suzuki K, Ohashi R, Ogawa H, Yamada T, Niwa H, Tsuneyoshi T,Sugimura H.J Surg Oncol. 2008 Nov 1;98(6):457-61. doi: 10.1002/jso.21130.PMID: 18683191

MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastriccancer and peptic ulcer in Japanese.Sugimoto M, Furuta T, Shirai N, Kodaira C, Nishino M, Yamade M, Ikuma M, Sugimura H, Ishizaki T, HishidaA.Life Sci. 2008 Aug 15;83(7-8):301-4. doi: 10.1016/j.lfs.2008.06.022. Epub 2008 Jul 3.PMID: 18644389

Comparison of estrogen receptor, progesterone receptor and Her-2 status in breast cancer pre- and post-neoadjuvant chemotherapy.Kasami M, Uematsu T, Honda M, Yabuzaki T, Sanuki J, Uchida Y, Sugimura H.Breast. 2008 Oct;17(5):523-7. doi: 10.1016/j.breast.2008.04.002. Epub 2008 Jun 5.PMID: 18534850

His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreaticcancer risk.Ohnami S, Sato Y, Yoshimura K, Ohnami S, Sakamoto H, Aoki K, Ueno H, Ikeda M, Morizane C, Shimada K,Sakamoto Y, Esaki M, Saito I, Hirose H, Saito D, Sugimura H, Kosuge T, Okusaka T, Yoshida T.Gastroenterology. 2008 Aug;135(2):477-88. doi: 10.1053/j.gastro.2008.04.016. Epub 2008 Apr 18.PMID: 18515090

Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.Study Group of Millennium Genome Project for Cancer, Sakamoto H, Yoshimura K, Saeki N, Katai H,Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T,Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, AndoM, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S,Yanagihara K, Yoon KA, Kook MC, Lee YS, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S.Nat Genet. 2008 Jun;40(6):730-40. doi: 10.1038/ng.152. Epub 2008 May 18.PMID: 18488030

CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis amongAsian populations.

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Lee KM, Kang D, Clapper ML, Ingelman-Sundberg M, Ono-Kihara M, Kiyohara C, Min S, Lan Q, Le MarchandL, Lin P, Lung ML, Pinarbasi H, Pisani P, Srivatanakul P, Seow A, Sugimura H, Tokudome S, Yokota J, Taioli E.Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1120-6. doi: 10.1158/1055-9965.EPI-07-2786. Epub 2008 May 7.PMID: 18463401 Free Article

Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally bybeta-catenin/TCF.Torisu Y, Watanabe A, Nonaka A, Midorikawa Y, Makuuchi M, Shimamura T, Sugimura H, Niida A, Akiyama T,Iwanari H, Kodama T, Zeniya M, Aburatani H.Cancer Sci. 2008 Jun;99(6):1139-46. doi: 10.1111/j.1349-7006.2008.00814.x. Epub 2008 Apr 21.PMID: 18429952 Free Article

Loss of expression of EphB1 protein in gastric carcinoma associated with invasion and metastasis.Wang JD, Dong YC, Sheng Z, Ma HH, Li GL, Wang XL, Lu GM, Sugimura H, Jin J, Zhou XJ.Oncology. 2007;73(3-4):238-45. doi: 10.1159/000127421. Epub 2008 Apr 17.PMID: 18424888

[Familial aggregation of gastric cancer].Sugimura H.Gan To Kagaku Ryoho. 2008 Apr;35(4):551-6. Review. Japanese.PMID: 18408421

Fluorescence-labeled methylation-sensitive amplified fragment length polymorphism (FL-MS-AFLP) analysisfor quantitative determination of DNA methylation and demethylation status.Kageyama S, Shinmura K, Yamamoto H, Goto M, Suzuki K, Tanioka F, Tsuneyoshi T, Sugimura H.Jpn J Clin Oncol. 2008 Apr;38(4):317-22. doi: 10.1093/jjco/hyn021. Epub 2008 Mar 19.PMID: 18353868

Detection of chromosome changes in pathology archives: an application of microwave-assisted fluorescencein situ hybridization to human carcinogenesis studies.Sugimura H.Carcinogenesis. 2008 Apr;29(4):681-7. doi: 10.1093/carcin/bgn046. Epub 2008 Feb 18. Review.PMID: 18283042

Congenital anaplastic astrocytoma differentiated into pilocytic astrocytoma: an autopsy case.Arai Y, Tsuchida T, Tanioka F, Sugimura H, Watanabe C, Hongo T, Tsutsui Y.Neuropathology. 2008 Aug;28(4):433-9. doi: 10.1111/j.1440-1789.2008.00866.x. Epub 2008 Feb 16.PMID: 18282169

Association between genetic polymorphisms of the base excision repair gene MUTYH and increasedcolorectal cancer risk in a Japanese population.Tao H, Shinmura K, Suzuki M, Kono S, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, FutamiK, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N, Sugimura H.Cancer Sci. 2008 Feb;99(2):355-60. doi: 10.1111/j.1349-7006.2007.00694.x.PMID: 18271935 Free Article

Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk ofbone and soft tissue sarcomas in Japan.Nakayama R, Sato Y, Masutani M, Ogino H, Nakatani F, Chuman H, Beppu Y, Morioka H, Yabe H, Hirose H,Sugimura H, Sakamoto H, Ohta T, Toyama Y, Yoshida T, Kawai A.Cancer Sci. 2008 Feb;99(2):333-9. doi: 10.1111/j.1349-7006.2007.00692.x.PMID: 18271933 Free Article

EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-

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small cell lung carcinomas.Shinmura K, Kageyama S, Tao H, Bunai T, Suzuki M, Kamo T, Takamochi K, Suzuki K, Tanahashi M, Niwa H,Ogawa H, Sugimura H.Lung Cancer. 2008 Aug;61(2):163-9. doi: 10.1016/j.lungcan.2007.12.013. Epub 2008 Feb 1.PMID: 18242762

Colonic fistula associated with severe acute pancreatitis: report of two cases.Suzuki A, Suzuki S, Sakaguchi T, Oishi K, Fukumoto K, Ota S, Inaba K, Takehara Y, Sugimura H, UchiyamaT, Konno H.Surg Today. 2008;38(2):178-83. doi: 10.1007/s00595-007-3593-6. Epub 2008 Feb 1.PMID: 18239882

CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcoholdrinking.Gao CM, Takezaki T, Wu JZ, Chen MB, Liu YT, Ding JH, Sugimura H, Cao J, Hamajima N, Tajima K.World J Gastroenterol. 2007 Nov 21;13(43):5725-30.PMID: 17963298 Free PMC Article

p53-dependent change in replication timing of the human genome.Watanabe Y, Shibata K, Sugimura H, Maekawa M.Biochem Biophys Res Commun. 2007 Dec 14;364(2):289-93. Epub 2007 Oct 15.PMID: 17949684

Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic livergastrointestinal stromal tumors.Kikuchi H, Yamamoto M, Hiramatsu Y, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Sugimura H,Kitagawa M, Kanai T, Kitayama Y, Kanda T, Nishikura K, Konno H.Cancer Sci. 2007 Nov;98(11):1734-9.PMID: 17894554 Free Article

Association between CDH1 haplotypes and gastric cancer risk in a Japanese population.Yamada H, Shinmura K, Ikeda S, Tao H, Otani T, Hanaoka T, Tsuneyoshi T, Tsugane S, Sugimura H.Scand J Gastroenterol. 2007 Dec;42(12):1479-85.PMID: 17852867

PIK3CA mutation and amplification in human lung cancer.Okudela K, Suzuki M, Kageyama S, Bunai T, Nagura K, Igarashi H, Takamochi K, Suzuki K, Yamada T, NiwaH, Ohashi R, Ogawa H, Mori H, Kitamura H, Kaneko T, Tsuneyoshi T, Sugimura H.Pathol Int. 2007 Oct;57(10):664-71. Erratum in: Pathol Int. 2007 Nov;57(11):757.PMID: 17803655

Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer inJapanese subjects.Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Sugimura H, Hishida A.J Gastroenterol Hepatol. 2007 Sep;22(9):1443-9.PMID: 17716348

Identification and characterization of a novel germ line p53 mutation in familial gastric cancer in the Japanesepopulation.Yamada H, Shinmura K, Okudela K, Goto M, Suzuki M, Kuriki K, Tsuneyoshi T, Sugimura H.Carcinogenesis. 2007 Sep;28(9):2013-8. Epub 2007 Aug 8.PMID: 17690113

Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a

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prognostic classifier.Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, Kumamoto K, Mechanic LE, Matsumoto S, YokotaJ, Shibata T, Sugimura H, Gemma A, Kudoh S, Wang XW, Harris CC.J Natl Cancer Inst. 2007 Aug 15;99(16):1257-69. Epub 2007 Aug 8.PMID: 17686824

Differential expression of EphA7 receptor tyrosine kinase in gastric carcinoma.Wang J, Li G, Ma H, Bao Y, Wang X, Zhou H, Sheng Z, Sugimura H, Jin J, Zhou X.Hum Pathol. 2007 Nov;38(11):1649-56. Epub 2007 Jul 31.PMID: 17669470

Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growthfactor receptor gene mutation.Takamochi K, Suzuki K, Sugimura H, Funai K, Mori H, Bashar AH, Kazui T.Lung Cancer. 2007 Oct;58(1):149-55. Epub 2007 Jun 4.PMID: 17548126

Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk inJapanese.Sugimoto M, Furuta T, Shirai N, Kodaira C, Nishino M, Ikuma M, Sugimura H, Hishida A.Carcinogenesis. 2007 Sep;28(9):2036-40. Epub 2007 Mar 26.PMID: 17389608

Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways.Ikeda M, Hirabayashi S, Fujiwara N, Mori H, Kawata A, Iida J, Bao Y, Sato Y, Iida T, Sugimura H, Hata Y.Exp Cell Res. 2007 Apr 15;313(7):1484-95. Epub 2007 Feb 23.PMID: 17367779

Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development ofpeptic ulcer and gastric cancer.Sugimoto M, Furuta T, Shirai N, Nakamura A, Xiao F, Kajimura M, Sugimura H, Hishida A.J Gastroenterol Hepatol. 2007 Jan;22(1):51-9.PMID: 17201881

p16INK4A in oral squamous cell carcinomas--a correlation with biological behaviors: immunohistochemicaland FISH analysis.Suzuki H, Sugimura H, Hashimoto K.J Oral Maxillofac Surg. 2006 Nov;64(11):1617-23.PMID: 17052587

Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks inJapan.Sugimoto M, Furuta T, Shirai N, Ikuma M, Sugimura H, Hishida A.Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1929-34.PMID: 17035401 Free Article

[Manifestation of liver metastasis 13 years after gastrectomy for gastric GIST].Kikuchi H, Yamamoto M, Hiramatsu Y, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Sugimura H, KonnoH.Nihon Shokakibyo Gakkai Zasshi. 2006 Sep;103(9):1055-60. Japanese.PMID: 16953103

Repeated fluorescence in situ hybridization by a microwave-enhanced protocol.

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Kitayama Y, Igarashi H, Kozu T, Nagura K, Ohashi Y, Sugimura H.Pathol Int. 2006 Sep;56(9):490-3.PMID: 16930328

Development of the adductome approach to detect DNA damage in humans.Kanaly RA, Hanaoka T, Sugimura H, Toda H, Matsui S, Matsuda T.Antioxid Redox Signal. 2006 May-Jun;8(5-6):993-1001.PMID: 16771689

Overexpression of heat shock protein 27 is associated with good prognosis in the patient with oral squamouscell carcinoma.Suzuki H, Sugimura H, Hashimoto K.Br J Oral Maxillofac Surg. 2007 Mar;45(2):123-9. Epub 2006 May 23.PMID: 16720063

Chromosomal numerical abnormalities in early stage lung adenocarcinoma.Sano T, Kitayama Y, Igarashi H, Suzuki M, Tanioka F, Chida K, Okudela K, Sugimura H.Pathol Int. 2006 Mar;56(3):117-25.PMID: 16497244

Chromosomal numerical abnormality profiles of gastrointestinal stromal tumors.Yamashita K, Igarashi H, Kitayama Y, Ozawa T, Kiyose S, Konno H, Kazui T, Ishikawa S, Aburatani H,Tanioka F, Suzuki M, Sugimura H.Jpn J Clin Oncol. 2006 Feb;36(2):85-92. Epub 2006 Feb 1.PMID: 16452129

Immunohistochemical and genetic features of gastric and metastatic liver gastrointestinal stromal tumors:sequential analyses.Kikuchi H, Yamashita K, Kawabata T, Yamamoto M, Hiramatsu Y, Kondo K, Baba M, Ohta M, Kamiya K,Tanaka T, Suzuki S, Kitagawa K, Kitagawa M, Sugimura H, Konno H.Cancer Sci. 2006 Feb;97(2):127-32. Erratum in: Cancer Sci. 2006 Apr;97(4):340.PMID: 16441423 Free Article

Mdm2-mediated pRB downregulation is involved in carcinogenesis in a p53-independent manner.Miwa S, Uchida C, Kitagawa K, Hattori T, Oda T, Sugimura H, Yasuda H, Nakamura H, Chida K, Kitagawa M.Biochem Biophys Res Commun. 2006 Feb 3;340(1):54-61. Epub 2005 Dec 6.PMID: 16343421

Nonrandom chromosomal numerical abnormality as a new molecular cytogenetic tumor marker--aretrospective study of 60 gastric cancer cases.Kitayama Y, Sugimura H.Rinsho Byori. 2005 Oct;53(10):881-6.PMID: 16296333

Simultaneous imaging of membrane antigen and the corresponding chromosomal locus in pathologyarchives.Igarashi H, Yamashita K, Suzuki M, Kitayama Y, Isogaki J, Maruyama K, Sunayama K, Tsuda H, Ozawa T,Kiyose S, Sugimura H.Pathol Int. 2005 Dec;55(12):753-6.PMID: 16287489

Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression.Yamada H, Shinmura K, Tsuneyoshi T, Sugimura H.J Genet. 2005 Aug;84(2):131-6.

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A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associatedwith gastric cancer in the Japanese population.Aoki M, Yamamoto K, Ohyama S, Yamamura Y, Takenoshita S, Sugano K, Minamoto T, Kitajima M, SugimuraH, Shimada S, Noshiro H, Hiratsuka M, Sairenji M, Ninomiya I, Yano M, Uesaka K, Matsuno S, Maehara Y,Aikou T, Sasazuki T.Biochem Biophys Res Commun. 2005 Sep 23;335(2):566-74.PMID: 16087163

Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study.Raimondi S, Boffetta P, Anttila S, Bröckmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Dragani TA, Garte S,Gsur A, Haidinger G, Hirvonen A, Ingelman-Sundberg M, Kalina I, Lan Q, Leoni VP, Le Marchand L, LondonSJ, Neri M, Povey AC, Rannug A, Reszka E, Ryberg D, Risch A, Romkes M, Ruano-Ravina A, Schoket B,Spinola M, Sugimura H, Wu X, Taioli E.Mutat Res. 2005 Dec 30;592(1-2):45-57. Epub 2005 Jul 11.PMID: 16009381

Downregulation of EphA7 by hypermethylation in colorectal cancer.Wang J, Kataoka H, Suzuki M, Sato N, Nakamura R, Tao H, Maruyama K, Isogaki J, Kanaoka S, Ihara M,Tanaka M, Kanamori M, Nakamura T, Shinmura K, Sugimura H.Oncogene. 2005 Aug 25;24(36):5637-47.PMID: 16007213

Overexpression of MUC13 is associated with intestinal-type gastric cancer.Shimamura T, Ito H, Shibahara J, Watanabe A, Hippo Y, Taniguchi H, Chen Y, Kashima T, Ohtomo T, TaniokaF, Iwanari H, Kodama T, Kazui T, Sugimura H, Fukayama M, Aburatani H.Cancer Sci. 2005 May;96(5):265-73.PMID: 15904467 Free Article

Pilot study of arbitrarily primed PCR-single stranded DNA conformation polymorphism analysis for screeninggenetic polymorphisms related to specific phenotypes.Maekawa M, Taniguchi T, Uramoto T, Higashi H, Horii T, Takeshita A, Sugimura H, Kanamori M.Clin Chim Acta. 2005 May;355(1-2):181-4.PMID: 15820493

EPHA2/EFNA1 expression in human gastric cancer.Nakamura R, Kataoka H, Sato N, Kanamori M, Ihara M, Igarashi H, Ravshanov S, Wang YJ, Li ZY,Shimamura T, Kobayashi T, Konno H, Shinmura K, Tanaka M, Sugimura H.Cancer Sci. 2005 Jan;96(1):42-7.PMID: 15649254 Free Article

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.Uchida C, Miwa S, Kitagawa K, Hattori T, Isobe T, Otani S, Oda T, Sugimura H, Kamijo T, Ookawa K, YasudaH, Kitagawa M.EMBO J. 2005 Jan 12;24(1):160-9. Epub 2004 Dec 2.PMID: 15577944 Free PMC Article

[Two cases of postoperative recurrence of gastric GIST treated by imatinib].Kikuchi H, Konn H, Kamiya K, Baba M, Ohta M, Kondo K, Hiramatsu Y, Yamamoto M, Tanaka T, Sugimura H,Ohashi M, Kanda T, Nakamura S.Gan To Kagaku Ryoho. 2004 Oct;31(10):1569-73. Japanese.PMID: 15508453

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Amplicons on human chromosome 11q are located in the early/late-switch regions of replication timing.Watanabe Y, Ikemura T, Sugimura H.Genomics. 2004 Nov;84(5):796-805.PMID: 15475258

[A case of gastric GIST treated preoperatively by imatinib mesylate].Hiramatsu Y, Konno H, Kamiya K, Baba M, Ohta M, Kondo K, Yamamoto M, Kikuchi H, Tanaka T, SugimuraH, Nakamura S.Gan To Kagaku Ryoho. 2004 Aug;31(8):1219-23. Japanese.PMID: 15332547

JAM4 enhances hepatocyte growth factor-mediated branching and scattering of Madin-Darby canine kidneycells.Mori H, Hirabayashi S, Shirasawa M, Sugimura H, Hata Y.Genes Cells. 2004 Sep;9(9):811-9.PMID: 15330858 Free Article

Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.Shinmura K, Tao H, Goto M, Igarashi H, Taniguchi T, Maekawa M, Takezaki T, Sugimura H.Carcinogenesis. 2004 Dec;25(12):2311-7. Epub 2004 Aug 19.PMID: 15319300

Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantialexpression of KLK12 protein having serine protease activity.Shinmura K, Tao H, Yamada H, Kataoka H, Sanjar R, Wang J, Yoshimura K, Sugimura H.Hum Mutat. 2004 Sep;24(3):273-4.PMID: 15300858

Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening.Kanaoka S, Yoshida K, Miura N, Sugimura H, Kajimura M.Gastroenterology. 2004 Aug;127(2):422-7.PMID: 15300574

Methylation of mitochondrial DNA is not a useful marker for cancer detection.Maekawa M, Taniguchi T, Higashi H, Sugimura H, Sugano K, Kanno T.Clin Chem. 2004 Aug;50(8):1480-1. No abstract available.PMID: 15277367 Free Article

Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibilityto esophageal and stomach cancer with smoking.Gao CM, Takezaki T, Wu JZ, Liu YT, Ding JH, Li SP, Su P, Hu X, Kai HT, Li ZY, Matsuo K, Hamajima N,Sugimura H, Tajima K.Asian Pac J Cancer Prev. 2004 Apr-Jun;5(2):133-8.PMID: 15244514 Free Article

A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrantmRNA transcript encoding a truncated MYH protein not localized in the nucleus.Tao H, Shinmura K, Hanaoka T, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Ozawa T, Tsujinaka T, Li Z,Yamaguchi S, Yokota J, Sugimura H, Tsugane S.Carcinogenesis. 2004 Oct;25(10):1859-66. Epub 2004 Jun 3.PMID: 15180946

Three-dimensional microarray compared with PCR-single-strand conformation polymorphism analysis/DNAsequencing for mutation analysis of K-ras codons 12 and 13.

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Maekawa M, Nagaoka T, Taniguchi T, Higashi H, Sugimura H, Sugano K, Yonekawa H, Satoh T, Horii T, ShiraiN, Takeshita A, Kanno T.Clin Chem. 2004 Aug;50(8):1322-7. Epub 2004 Jun 3.PMID: 15178652 Free Article

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.Smits KM, Benhamou S, Garte S, Weijenberg MP, Alamanos Y, Ambrosone C, Autrup H, Autrup JL, BaranovaH, Bathum L, Boffetta P, Bouchardy C, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper ML, Coutelle C, DalyAK, Muzi G, Dolzan V, Duzhak TG, Farker K, Golka K, Haugen A, Hein DW, Hildesheim A, Hirvonen A, HsiehLL, Ingelman-Sundberg M, Kalina I, Kang D, Katoh T, Kihara M, Ono-Kihara M, Kim H, Kiyohara C, KremersP, Lazarus P, Le Marchand L, Lechner MC, London S, Manni JJ, Maugard CM, Morgan GJ, Morita S, Nazar-Stewart V, Kristensen VN, Oda Y, Parl FF, Peters WH, Rannug A, Rebbeck T, Pinto LF, Risch A, Romkes M,Salagovic J, Schoket B, Seidegard J, Shields PG, Sim E, Sinnett D, Strange RC, Stucker I, Sugimura H, To-Figueras J, Vineis P, Yu MC, Zheng W, Pedotti P, Taioli E.Int J Cancer. 2004 Jun 10;110(2):266-70.PMID: 15069692 Free Article

Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapy.Furuta T, Shirai N, Xiao F, El-Omar EM, Rabkin CS, Sugimura H, Ishizaki T, Ohashi K.Clin Gastroenterol Hepatol. 2004 Jan;2(1):22-30.PMID: 15017629

Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, Sugimura H.EMBO J. 2004 Mar 10;23(5):1075-88. Epub 2004 Feb 26.PMID: 14988728 Free PMC Article

Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer.Kataoka H, Igarashi H, Kanamori M, Ihara M, Wang JD, Wang YJ, Li ZY, Shimamura T, Kobayashi T,Maruyama K, Nakamura T, Arai H, Kajimura M, Hanai H, Tanaka M, Sugimura H.Cancer Sci. 2004 Feb;95(2):136-41.PMID: 14965363 Free Article

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