publications, josephine arendt - guildford arendt... · publications, josephine arendt....

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Publications, Josephine Arendt. Publications have been divided into: 1) full peer reviewed papers, 2) invited reviews, book chapters and conference proceedings (a few recent abstracts are cited at the end), 3) books written and/or edited, 4) other publications including UK Government HSE reports. Most published abstracts are not included. 1) Full Papers Contractor S.F. and Wragg J.: Column chromatography of tryptophan and some related indoles. J. Chromat., 15 (1964), 118. Contractor S.F. and Wragg J.: Resolution of the optical isomers of D, L- tryptophan by paper and thin layer chromatography. Nature, 208 (1965), 1971. Contractor S.F., Sandler M. and Wragg J.: 6-Hydroxytryptophan formation by Chromobacterium violaceum. Life Sci., 3 (1966), 999. Arendt J., Contractor S.F. and Sandler M.: Alternative pathways of 5- hydroxyindole metabolism. I. A comparison of D- and L-5-hydroxytryptophan metabolism in the rat. Biochem. Pharmacol., 16 (1967), 413. Arendt J., Contractor S.F. and Sandler M.: Alternative pathways of hydroxyindole metabolism. II. The role of transamination in the metabolism of D- hydroxytryptophan in the rat. Biochem. Pharmacol., 16 (1967), 419. Arendt J., Charollais E., Deshusses J. and Posternak Th.: Contribution a l'etude due meso-inositol chez le rat. III. Catabolisme due mesoinositol chez l'animal diabetique. C.R. des Sciences, SPHN, Geneve 5 (1970), 129-138. Lacourt G., Sizonenko P.C., Englehorn A., Berli C., Arendt J., Paunier L. and Beguin F.: Determination due cortisol dans le liquide aminotique. Indice de maturation foetale? Helv. Ped. Acta, 13 (1975) suppl. 35, 13. Arendt J. and Beguin F.: Acide 5-hydroxy-indole-acetique: reflet du systeme nerveux central foetal? Gynaek. Rdsch., 15 (1975), 43-46. Arendt J., Paunier L. and Sizonenko P.C.: Estimation of plasma melatonin concentrations in children and adults during the light and dark phases of the day. Pediat. Res., 9 (1975), 682. Arendt J., Paunier L. and Sizonenko PC. Melatonin radioimmunoassay. J. Clin. Endocrinol. Metab., 40 (1975), 347-350. Wetterberg L. and Arendt J. Melatonin and menstrual cycle. Lancet ii , (1975), 417. Wetterberg L., Arendt J., Paunier L., Sizonenko P.C., van Donselaar W. and Heyden T.: Human 1

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Page 1: Publications, Josephine Arendt - Guildford Arendt... · Publications, Josephine Arendt. Publications have been divided into: 1) full peer reviewed papers, 2) invited reviews, book

Publications, Josephine Arendt. Publications have been divided into: 1) full peer reviewed papers, 2) invited reviews, book chapters and conference proceedings (a few recent abstracts are cited at the end), 3) books written and/or edited, 4) other publications including UK Government HSE reports. Most published abstracts are not included. 1) Full Papers Contractor S.F. and Wragg J.: Column chromatography of tryptophan and some related indoles. J. Chromat., 15 (1964), 118. Contractor S.F. and Wragg J.: Resolution of the optical isomers of D, L- tryptophan by paper and thin layer chromatography. Nature, 208 (1965), 1971. Contractor S.F., Sandler M. and Wragg J.: 6-Hydroxytryptophan formation by Chromobacterium violaceum. Life Sci., 3 (1966), 999. Arendt J., Contractor S.F. and Sandler M.: Alternative pathways of 5- hydroxyindole metabolism. I. A comparison of D- and L-5-hydroxytryptophan metabolism in the rat. Biochem. Pharmacol., 16 (1967), 413. Arendt J., Contractor S.F. and Sandler M.: Alternative pathways of hydroxyindole metabolism. II. The role of transamination in the metabolism of D- hydroxytryptophan in the rat. Biochem. Pharmacol., 16 (1967), 419. Arendt J., Charollais E., Deshusses J. and Posternak Th.: Contribution a l'etude due meso-inositol chez le rat. III. Catabolisme due mesoinositol chez l'animal diabetique. C.R. des Sciences, SPHN, Geneve 5 (1970), 129-138. Lacourt G., Sizonenko P.C., Englehorn A., Berli C., Arendt J., Paunier L. and Beguin F.: Determination due cortisol dans le liquide aminotique. Indice de maturation foetale? Helv. Ped. Acta, 13 (1975) suppl. 35, 13. Arendt J. and Beguin F.: Acide 5-hydroxy-indole-acetique: reflet du systeme nerveux central foetal? Gynaek. Rdsch., 15 (1975), 43-46. Arendt J., Paunier L. and Sizonenko P.C.: Estimation of plasma melatonin concentrations in children and adults during the light and dark phases of the day. Pediat. Res., 9 (1975), 682. Arendt J., Paunier L. and Sizonenko PC. Melatonin radioimmunoassay. J. Clin. Endocrinol. Metab., 40 (1975), 347-350. Wetterberg L. and Arendt J. Melatonin and menstrual cycle. Lancet ii, (1975), 417. Wetterberg L., Arendt J., Paunier L., Sizonenko P.C., van Donselaar W. and Heyden T.: Human

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serum melatonin changes during the menstrual cycle. J. Clin. Endocrinol. Metab., 42 (1976), 185-188. Wilkinson, M., J. Arendt, D. de Ziegler and K.B. Ruf: Changes in sensitivity of pinealocyte--receptors during precocious sexual maturation or after postnatal sterilization with estrogen in the female rat. Ann. Biol. Anim., Biochim. Biophys., 16 (1976), 457- 464. Heyden, T., L. Wetterberg, and J. Arendt. Normal-variationer au melatonin i serum och CSF hos manniska. Nord. Psyk. Tidskrift, 30, (1976), 522-527 Freund, D., J. Arendt and L. Vollrath: Immunohistological demonstration of melatonin in the rat pineal gland. J. Cell and Tissue Res., 181 (1977), 239-244. Wilkinson, M., J. Arendt, J. Bradtke and D. de Ziegler: Determinatin of dark- induced elevation of pineal N-acetyl-transferase with simultaneous radioimmunoassay of melatonin in pineal, serum and pituitary of the male rat. J. Endocrinol., 72 (1977), 243-244. Arendt, J., L. Wetterberg, L. Paunier, P.C. Sizonenko and T. Heyden: Melatonin radioimmunoassay: human serum and cerebrospinal fluid. Hormone Res., 8 (1977), 65-75. Arendt, J., A. Wirz-Justice and J. Bradtke: Annual rhythm of serum melatonin in man. Neuroscience Letters, 7 (1977), 327-330. Arendt, J., A. Wirz-Justice and J. Bradtke: Circadian, diurnal and circannual rhythms of serum melatonin and platelet serotonin in man. Chronobiologia, 4 (1977), 96-97. Wilkinson, M., and J. Arendt: Effects of estrogen and progesterone on rat pineal N- acetyltransferase activity and melatonin production. Experientia, 34 (1978), 667-668. Arendt, J., A. Wirz-Justice, A. Symons, B. Vivien-Roels and M. Wilkinson: Radioimmunoassayable melatonin in different species. Proceedings of the Society for Endocrinology, J. Endocinol., 79 (1978), 25-26P. Vivien-Roels, B., J. Arendt and J. Bradtke: Circadian and circannual fluctuations of pineal indoleamines (serotonin and melatonin) in Testudo hermanni Gmelin (Reptila, Chelonia): I. Under natural conditions of photoperiod and temperature. Gen. and Comp. Endocrinol., 37 (1979), 197-210. Vivien-Roels, B., and J. Arendt: Variations circadiennes et circannuelles de la melatonine epiphysaire chez Testudo hermanni G. (Reptile-Chelonien) dans des conditions naturelles d'eclairement et de temperature. Ann. Endocrinologie (Paris), 40 (1979), 93-94. Arendt, J., A. Wirz-Justice, J. Bradtke and M. Kornemark: Long-term studies on immunoreactive human melatonin. Ann. Clin. Biochem. 16 (1979), 307-312. Wirz-Justice, A. and J.Arendt: Plasma melatonin and antidepressant drugs. Lancet, i (1980), 234.

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(letter) Wirz-Justice, A., J. Arendt and A. Marston: Antidepressant drugs elevate rat pineal and plasma melatonin. Experientia, 36, (1980), 442-444. Arendt, J., J.M. Forbes, W.B. Brown and A. Marston: Effect of pinealectomy on immunoassayable melatonin in sheep. J. Endocr., 85 (1980) lP. Arendt, J., A.K. Ho, C. Laud, A. Marston, V. Nohria, J.A. Smith and A.M. Symons: Differential effect of Benserazide (R04-4602) on the concentration of indoleamines in rat pineal and hypothalamus. Br. J. Pharmac., 72 (1981), 257-262. Viven-Roels, B., P. Pevet, M.P. Dubois, J. Arendt and G.M. Brown: Immunohistochemical evidence for the presence of melatonin in the pineal gland, the retina and the Harderian gland. J. Cell. Tissue Res., 217 (1981), 105-115. Arendt, J., A.M. Symons and C. Laud: Pineal function in the sheep: evidence for a possible mechanism mediating seasonal reproductive activity. Experientia, 37 (1981), 584-589. Symons, A.M. and J. Arendt: Lack of effect of melatonin on the pituitary response to LHRH in the ewe. J. Reprod. Fert., 64, (1982), 103-106. Arendt, J., S. Hampton, J. English, P. Kwasowski and V. Marks: 24-Hour profiles of melatonin, cortisol, insulin, C-peptide and GIP following a meal and subsequent fasting. Clinical Endocrinology, 16, (1982), 89-95. Ferrier, I.N., Johnstone, E.C., Crow, T.J. and Arendt, J. Melatonin/cortisol ratio in psychiatric illness. Lancet i, (1982), 1070. Ferrier, I.N., Arendt, J., Johnstone, E.C. and Crow, T.J. Reduced nocturnal melatonin secretion in chronic schizophrenia: relationship to body weight. Clinical Endocrinology, 17, (1982), 181-187. Fraser, S., Cowen, P., Franklin, M., Franey, C. and Arendt, J. A direct radioimmuno-assay for plasma melatonin. Clinical Chemistry (1982), 29, 296-297. Arendt, J., Symons, A.M., Laud, C.A. and Pryde, S.J. Melatonin can induce early onset of the breeding season in ewes. J. Endocr. (1983) 97, 395-400. Laud, C.A., Arendt, J., Symons, A.M. and Pryde, S.J. Plasma melatonin increases in ewes following ovariectomy. J. Reprod. Fert. (1983) 68, 213-218. Symons, A.M., Arendt, J. and Laud, C.A. Melatonin feeding decreases prolactin levels in the ewe. J. Endocr. (1983) 99, 41-46. Thompson, C., Checkley, S.A., Corn, T., Franey, C. and Arendt, J. Down- regulation at pineal b-adrenoceptors in depressed patients treated with desipramine. Lancet (1983) i, 1101.

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Arendt, J., Borbely, A.A., Franey, C. and Wright, J. The effects of chronic, small doses of melatonin given in the late afternoon on fatigue in man: a preliminary study. Neurosci. Letts. (1984) 45, 317-321. O'Brian, I.A.D., I.G. Lewin, J.P. O'Hare, J. Arendt and R.J.M. Corrall. Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. Clin. Sci. (1984) 66, 39P. O’Brien IA, Lewin IG, O’Hare JP, et al. Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. Clin Endocrinol (Oxf) 1986;24:359–364 Vivien-Roels, B., Fevre-Montange, M., and Arendt, J. Long-term effect of environmental factors on pineal and gonadal function in the male tortoise, Testudo Hermanni Gmelin. J. Steroid Biochem. (1984) 20, 1480. Thompson, C., R. Obrecht, C. Franey, J. Arendt and S.A. Checkley. Neuroendocrine rhythms in a patient with the Kleine-Levin syndrome. Brit. J. Psychiatry (1985) 147, 440-443. Thompson, C., G. Mezey, T. Corn, C. Franey, J. English, J. Arendt and S.A. Checkley. The effect of desipramine upon melatonin and cortisol secretion in depressed and normal subjects. Brit. J. Psychiatry 147, 389-393. Checkley, S.A., C. Thompson, S. Burton, C. Franey and J. Arendt. Clinical studies of the effect of (+) and (-) oxaprotiline upon noradrenaline uptake. Psychopharmacol. (1985) 87, 116-118. Aldhous, M., C. Franey, J. Wright and J. Arendt. Plasma concentrations of melatonin in man following oral absorption of different preparations. Brit. J. Clin. Pharmacol. (1985) 19, 517-521. Arendt, J., C. Bojkowski, C. Franey, J. Wright, V. Marks. Immunoassay of 6- hydroxy-melatonin sulphate (aMT6s) in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol. J. Clin. Endocrinol. Metab. (1985) 60, 1166- 1173. Symons, A.M., Arendt, J. and Pryde, S.J. Differential effects of melatonin on the stimulated release of LH from dispersed pituitary cells of the prepubertal female rat. J. Endocr.(1985) 107, 107-112. Marks, V., English, J., Aherne, G.W. and Arendt, J. Chronopharmacology. Clin. Biochem. (1985) 18,154-157. Wehr, T.A., Jacobsen, F.M., Sack, D.A., Arendt, J. Tamarkin, L. and Rosenthal, N.E. The efficacy of phototherapy in seasonal affective disorder appears not to depend on its timing or its effect on melatonin secretion. Arch. Gen. Psychiatr. (1986), 43, 870- 875. Wright, J., Aldhous, M., Franey, C., English, J. and Arendt, J. The effects ofexogenous melatonin on endocrine function in man. Clin. Endocr. (1986) 24, 375-382. Skene, D., Smith, I and Arendt, J. Radioimmunoassay of pineal 5- methoxytryptophol in different

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species: Comparison with pineal melatonin content. J.Endocr. (1986), 110, 177-184. Franey, C., Burton, S., Checkley, S. and Arendt, J. Acute desipramine stimulates melatonin and 6-hydroxymelatonin sulphate production in man. Brit.J.Clin.Pharmacol. (1986), 22, 73-79. English, J., Poulton, A.L., Arendt, J. and Symons, A.M. A comparison of the efficiency of melatonin treatments in advancing oestrus in ewes. J.Reproduc.Fert., (1986) 77, 321-327. O'Hare, J.P., O'Brien, A.D., Arendt, J..(exp) Astley, P., Ratcliffe, W., Andrews, H., Walters, R. and Corrall, R.J.M. Does melatonin deficiency cause the enlarged genitalia of the Fragile-X-syndrome? Clin.Endocr., (1986) 24, 327-333. Arendt, J., Aldhous, M. and Marks, V. Alleviation of jet-lag by melatonin: preliminary results of controlled double-blind trial. Brit.Med.J. (1986) 292, 1170. Griffiths, P.A., Folkard, S., Bojkowski, C., English, J. and Arendt, J. Persistent 24h variations of urinary 6-hydroxymelatonin sulphate and cortisol in Antarctica. Experientia (1986) 42, 430-432. Arendt, J. and Marks, V. Jeg lag and melatonin. Lancet, ii, (1986) (letter). Arendt, J. and Broadway, J. Phase response of human melatonin rhythms to bright light in Antarctica. J. Physiol. 377 (1986) 68P. Broadway, J. and Arendt, J. Delayed recovery of sleep and melatonin rhythms following night-shift work in winter compared to spring in Antarctica. Lancet, ii, (1986). Poulton, A.L., English, J., Symons, A.M. and Arendt, J. Effects of various melatonin treatments on plasma prolactin concentrations in the ewe. J. Endocrinol. (1986) 108, 287-292. Checkley, S.A., Winton, F., Corn, T., Franey, C. and Arendt, J. Effects of a phosphodiesterase inhibitor (rolipram) on the urinary excretion of 6- sulphatoxymelatonin in man. J. Psychopharmacol. (1987) 1, 20-22. Poulton, A.L., English, J., Symons, A.M. and Arendt, J. Changes in plasma concentrations of LH, FSH and prolactin in ewes receiving melatonin and short photoperiod treatment to induce early onset of breeding activity. J.Endocrinol., (1987), 112, 103-111. Symons, A.M., Arendt, J., Poulton, A.L. and English, J. Induction of early seasonal sensitivity to melatonin in Suffolk-cross ewes. Chronobiol. Internat., (1987), 4, 219-223. Bojkowski, C.J., Aldhous, M., English, J., Franey, C., Poulton, A.L., Skene, D. and Arendt, J. Suppression of nocturnal plasma melatonin and 6-sulphatoxymelatonin by bright and dim light in man. Horm. Met. Res., (1987) 19, 437-440. English, J., Aherne, G.W., Arendt, J. and Marks, V. The effect of abolition of the endogenous cortico-steroid rhythm on the circadian variation in methotrexate toxicity in rat. Cancer Chemother.

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Pharmacol., (1987) 19, 287-290. English, J., Arendt, J., Poulton, A.L. and Symons, A.M. Short term variations of circulating melatonin in the ewe. J.Pineal Res., (1987) 4, 359-366. English, J., Bojkowski, C., Poulton, A.L., Symons, A.M. and Arendt, J. Metabolism and pharmacokinetaics of melatonin in the ewe. J.Pineal Res., (1987) 4, 351-358. Broadway, J., Arendt, J. and Folkard, S. Bright light phase shifts the human melatonin rhythm during the Antarctic winter. Neurosci. Lett., (1987) 79, 185-189. Bojkowski, C., Arendt, J., Shih, M and Markey, S.P. Assessment of melatonin secretion in man by measurement of its metabolite: 6-sulphatoxymelatonin. Clin. Chem., (1987) 19, 437-440. Poulton, A., Symons, A.M., Kelly, M.J. and Arendt, J. Intraruminal soluble glass boluses containing melatonin can induce early onset of ovarian activity in ewes. J. Reprod.Fert., (1987) 80, 235-239. Arendt, J., Aldhous, M., Marks, M., Folkard, S., English, J., Marks, V. and Arendt, J.H. Some effects of jet-lag and their treatment by melatonin. Ergonomics, (1987) 30, 1379-1393. Morimasa, T., Wirz-Justice, A., Krauchi, K., Arendt, J. Baumann, J., Haeusler, A., Degen, P. and Feer, H. Chronic Methamphetanine and its withdrawal modity behavoural and neuroendocrine circadian rhythms. Physiol. Behav., (1987), 39, 699-705. Skene, D.J., Pevet, P., Vivien-Roels, B., Masson-Pevet, M. and Arendt, J. Effect of different photoperiods on concentrations of 5-methoxytryptophol and melatonin in the pineal gland of the Syrian hamster. J. Endocrinol., (1987) 114, 301- 309. Neville, S., Arendt, J. and Ioannides, C. A study of the mutagenicity of melatonin and 6-hydroxymelatonin. J. Pineal Res., (1988) 6, 73-76. Rosenthal, N.E., Jacobsen, F.M., Sack, D.A., Arendt, J., James, S.P., Parry, B.L. and Wehr, T.A. Atenolol in seasonal affective disorder: a test of the melatonin hypothesis. Amer. J. Psychiatry, (1988) 145, 52-56. Wynn, V.T. and Arendt, J. The effect of melatonin on the human electrocardiogram and simple reaction time responses. J. Pineal Res., (1988) 5, 427-436. Thompson, C., Franey, C., Arendt, J. and Checkley, S.A. A comparison of melatonin secretion in depressed patients and normal subjects. Brit. J. Psychiatry, (1988) 152, 260-265. Minors, D., Waterhouse, J., Hume, K., Marks, M., Arendt, J., Folkard, S. and Akerstedt, T. Sleep and circadian rhythms of temperature and urinary excretion on a 22.8h'day'. Chronobiol. Internat., (1990) 7,104-112.

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Aldhous, M. and Arendt, J. Radioimmunoassay for 6-sulphatoxymelatonin in urine using an iodinated tracer. Ann. Clin. Biochem., (1988) 25, 298-303. Arendt, J. and Ravault, J.P. Suppression of melatonin secretion in Ile de France rams by different light intensities. J. Pineal Res., (1988) 5, 245-250. Bojkowski, C. and Arendt, J. Annual changes in 6-sulphatoxymelatonin excretion in man. Acta Endocrinologica, (1988) 117, 470-476. Poulton, A.L., Brown, D.C., Thomas, E.M., Kelly, M.I., Symons, A.M. and Arendt, J. Use of an intraruminal soluble glass bolus containing melatonin for early lamb production. The Veterinary Record (1988) 122, 226-228. Arendt, J. Aldhous, M.and Wright, J. Synchronisation of a disturbed sleep-wake cycle in a blind man by melatonin treatment. The Lancet (1988) i, 772-773. English, J., Arendt, J., Symons, A.M., Poulton, A.L. and Tobler, I. Pineal and ovarian response to 22- and 24h days in the ewe. Biol. Reprod., (1988) 39, 9-18. Broadway,J.W. and Arendt, J. Seasonal and bright light changes of the phase position of the human melatonin rhythm in Antarctica. Arctic Med. Res., (1988), 47, (Suppl.), 201 - 203. Bearn J, Treasure J, Murphy M, Franey C, Arendt J, Wheeler M, Checkley SA. A study of sulphatoxymelatonin excretion and gonadotrophin status during weight gain in anorexia nervosa. Br J Psychiatry. 1988;152:372-6 Winton, F., Checkley, S.A., Corn, T., Huson, L.W., Franey, C. and Arendt, J. Effects of light treatment upon mood and melatonin in seasonal affective disorder. Psycholog. Med., (1989), 19, 585-590 Ravault, J.P., Arendt, J. and Tobler, I. Entrainment of melatonin rhythms in rams by symmetrical light-dark cycles of different period length. Chronobiol. Internat., (1989), 6, 329 - 339. Poulton, A.L., English, J., Symons, A.M. and Arendt, J. Plasma prolactin concentrations in pinealectomised ewes receiving melatonin treatment and pineal intact ewes maintained under a non-24h photoperiod. J. Pineal Res., (1989), 6, 243-252. Hajek, M., Meier-Ewart, K., Wirz-justice, A., Tobler, I., Arendt, J., Dick, H. and Fink, G. Bright white light does not improve narcoleptic symptoms. European Archives of Psychiatry and Neurological Sciences (1989), 394-398. Arendt, J., Labib, M.H., Bojkowski, C., Hanson, S. and Marks, V. Rapid decrease in melatonin production during treatment of delayed puberty with oestradiol in a case of craniopharyngioma. Lancet, (1989),i,1326.

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Palazidou, E., Franey, C., Arendt, J., Stahl, S. and Checkley, S. Evidence for a functional role of alpha-1-adrenoreceptors in the regulation of melatonin secretion in man. Psychoneuroendocrinol., (1989), 14, 131-135. Bearn J, Franey C, Arendt J, Checkley SA. A study of the effects of desipramine treatment alone and in combination with L-triiodothyronine on 6-sulphatoxymelatonin excretion in depressed patients. Br J Psychiatry. 1989 ;155:341-7. Lewis, D.F.V., Arendt, J. and English, J. Quantitative structure-activity relationships within a series of melatonin analogues and related indolealkylamines. J. Pharmacol. Exp. Therap., (1990), 252, 370-373. Folkard, S., Arendt, J., Aldhous, M. and Kennett, H. Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms. Neurosci. Lett., (1990), 113, 193-198. Skene, D.J., Bojkowski, C.J., Currie, J.E., Wright, J., Boulter, P.S. and Arendt, J. 6-Sulphatoxymelatonin production in breast cancer patients. J. Pineal Res., (1990), 8, 269-276. Skene, D.J., Churchill, A., Raynand, F., Pevet, P. and Arendt, J. Radioimmunoassay of 5-methoxytryptophol in plasma. Clin. Chem.. (1990), 35, 1749-1752. Deveson, S.L., Arendt, J. and Forsyth, I. Sensitivity of goats to a light pulse during the night as assessed by suppression of melatonin concentrations in the plasma. J. Pineal Res., (1990), 8, 169-177. Wirz-Justice, A., Graw, P., Krauchi, K., Gisin, B., Arendt, J., Aldhous, M. and Poldinger, W. Morning or night time melatonin is ineffective in Seasonal Affective Disorder. J Psychiatric Res., (1990), 24, 129-137. Bojkowski, C., and Arendt, J. Factors influencing urinary 6-sulphatoxymelatonin, a major melatonin metabolite, in normal human subjects. Clin. Endocrinol., (1990), 33, 435-444. Midwinter, M. and Arendt, J. Adaptation of the melatonin rhythm in human subjects following night-shift work in Antarctica. Neurosci. Lett., (1991), 122, 195-198. Critchley, P.H.S., Malcolm,P., Malcolm,G., Purkis,J.D.,Arendt, J. and Aldhous,M. Plasma melatonin levels are normal in Parkinsons disease: lack of effect of benserazide. J. Neurol. Neuropsychiat., (1991), 54, 91-92. Le Bars, D., Thivolle, P., Vitte, P.A., Bojkowski, C.J.,Chazot, G., Arendt, J., Frackowiak, R.S.J. and Claustrat, B. PET and plasma pharmacokinetic studies after bolus intravenous administration of 14C-melatonin in humans. Nuclear Medicine and Biology, (1991), 18, 357-362. Dahlitz, M., Alvarez, B.,Vignau, J., English, J., Arendt, J. and Parkes, J.D. Delayed sleep phase syndrome response to melatonin. Lancet i, (1991), 337, 1121-1124.

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Tobler, I.,Jaggi, K., Arendt, J. and Ravault,J.P. Long-term rest-activity pattern of sheep in stalls and in the field. Experientia, (1991), 47, 744-749. Palazidou, E., Skene, D.J., Arendt, J., Everitt, B. and Checkley, S.A. The acute and chronic effects of (+) and (-) oxaprotiline upon melatonin secretion in normal subjects. Psycholog. Med., (1992), 22, 61-67. Bhanji, S., Franey, C., Arendt, J. and Mattingley, D. Plasma melatonin levels in anorexia nervosa, Brit. J. Psychiatry, (1992), 161, 361-364. Owen, J. and Arendt,J. Melatonin suppression in human subjects by bright and dim light in Antarctica : time and season dependent effects. Neurosci. Lett., (1992), 137, 181-184. Deveson, S., Howarth, J., Arendt,J. and Forsyth, I.A. In-vitro autoradiographical localisation of melatonin binding sites in the caprine brain. J. Pineal Res., (1992), 13, 6-12. Deveson, S., Forsyth, I.A. and Arendt, J. Induced out-of-season breeding in British §Saanen dairy goats: use of artificial photoperiods and/or melatonin administration. Animal Reprod. Sci.. (1992) , 29, 1-15. Deveson,S., Forsyth,I.A. and Arendt,J. Retardation of pubertal development by prenatal long days in goat kids born in autumn. J. Reprod. Fert., (1992), 95, 629-637. Horne, J.A., Donlon, J. and Arendt, J. Green light treatment during sleep deprivation: effects on melaton and sleepiness. Sleep, 14 (1991) 233-240. Maurel, D., Mas, N., Roch, G., Boissin, J. and Arendt, J. Diurnal variations of urinary 6-sulphatoxymelatonin in male intact or ganglionectomised mink. J. Pineal Res., 13 (1992) 117-123. Arendt J, Bhanji S, Franey C, Mattingly D. Plasma melatonin levels in anorexia nervosa. Br J Psychiatry. 1992 ;161:361-4. Critchley, P.H.S., Malcolm, G.P., Malcolm, P.N., Gibb, W.R., Arendt, J. and Parkes, J.D. Fatigue and melatonin in Parkinsons Disease. J. Neurol Neurosurg Psychiatry 54/1(1991) 91-92. Wirz-Justice, A., Graw, P., Krauchi, K., Gisin, B., Jochum, A., Arendt, J., Fisch, H-U., Buddenberg,C. and Poldinger, W. Light therapy in seasonal affective disorder is independent of time of day or circadian phase. Arch. Gen. Psychiatry, 50 (12) (1993) 929-937. Folkard,S., Arendt,J. and Clarke,M. Can melatonin improve shiftworkers tolerance of the night shift? Some preliminary findings. Chronobiol. Internat., 10 (1993) 315-320. English, J., Middleton, B., Arendt, J. and Wirz-Justice, A. Rapid, direct measurement of melatonin in saliva using an iodinated tracer and solid phase second antibody. Annals of Clin. Biochem. 30 (1993) 415-416.

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Checkley, S.A., Murphy, D.G.M., Abbas, M., Marks, M., Winton, F., Palazidou, E., Murphy,D.M., Franey,C. and Arendt,J. Melatonin rhythms in seasonal affective disorder. Brit. J. Psychiatry, 163 (1993) 332-337. Murphy, D.G.M., Murphy, D.M., Abbas, M., Palazidou, E., Binnie, C., Arendt, J., Campos Costa, D., Checkley, S. A. Seasonal affective disorder response to light as measured by EEG, melatonin suppression and cerebral blood flow. Brit. J. Psychiatry, 163 (1993) 327-331. Deacon, S.J. and Arendt, J. Phase shifts in melatonin, 6-sulphatoxymelatonin and alertness rhythms after treatment with moderately bright light at night. Clin. Endocrinol., 40 (1994) 413-420. Skene, D.J., Bojkowski, C.J. and Arendt, J. Comparison of the effects of acute fluvoxamine and desipramine administration on melatonin and cortisol production in humans. Brit. J. Clin. Pharmacol., 37 (1994) 181-186. Deacon, S. and Arendt, J. Posture influences melatonin concentrations in plasma and saliva in humans. Neurosci. Lett., 167 (1994) 191-194. Deacon, S., English, J. and Arendt, J. Acute phase-shifting effects of melatonin associated with suppression of core body temperature. Neurosci. Lett., 178 (1994) 32-34. Ross, J.K., Arendt, J., Horne, J. and Haston, W. Night-shift work during Antarctic Winter: sleep characteristics and adaptation with bright light treatment .Physiol. Behav., 57 (1995) 1169-1174. . Deacon, S. and Arendt, J. Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans. Brain Res., 688 (1995) 77-85. Deacon S, Arendt J. Adapting to phase-shifts, I. An experimental model for jet lag and shift work. Physiol. Behav., 59 (1995) 665-673. Deacon S, Arendt J. Adapting to phase-shifts, II. Effects of melatonin and conflicting light treatment. Physiol. Behav., 59 (1996) 675-682. James, K., Skene, D.J., Lucini, V., Stankov, B. and Arendt, J. Characterisation of melatonin binding sites in the eye of the Japanese quail (Coturnix japonica). Gen. Comp. Endocrinol., 100 (1995) 188-196. Walker, A.B., English, J., Arendt, J. and Macfarlane, I.A. Hypogonadotropic hypogonadism and primary amenorrhoea associated with increased melatonin secretion from a cystic pineal lesion. Clin. Endocrinol., (1995). Lockley, SA., Tabandeh, H., Skene, D.J., Buttery, R., Bird, A.C., Defrance, R. and Arendt, J. Daytime naps and melatonin rhythms in blind people. Lancet, 346 (1995) 1491. Ruberg, F., Skene, D.J., Hanifin, J., Rollag, M., English, J., Arendt, J. and Brainard, G.C.

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Melatonin regulation in humans with colour vision deficiencies. J Clin Endocrinol Metab 1996; 81, 2980-2985.. Wirz-Justice A, Graw P, Krauchi K, Sarrafzadeh A, English J, Arendt J, Sand L. 'Natural' light treatment of seasonal affective disorder. J Affective Disorders 1996;37:109-120. Williams G, Pirmohamed J, Minors D, Waterhouse J, Buchan I, Arendt J, Edwards RHT. Dissociation of body temperature and melatonin secretion rhythms in patients with chronic fatigue syndrome. Clin Physiol 1996; 16:327-337. Middleton, B., Arendt, J. and Stone, B. (1996) Human circadian rhythms in constant dim light (<8 lux) with knowledge of clock time. J Sleep Res 1996; 5: 69-76. Hampton, S.M., Morgan, L.M., Lawrence, N., Anastasiadou, T., Noris, F., Deacon, S. and Arendt, J. Postprandial hormone and metabolic responses in simulated shift work. J Endocrinol 1996; 151:259-267. Middleton, B., Stone, B., Arendt, J. Melatonin and fragmented sleep patterns. Lancet 1996; 348:551-552. Lockley, S.W., Skene, D.J., Tabandeh, H., Bird, A.C., Defrance, R. Arendt, J. Relationship between napping and melatonin in the blind. J Biol Rhythms 1997; 12:16-25. Gebbie, F.E., Forsyth, I.A. and Arendt, J. Timing of melatonin treatment: differential effects on oestrus and coat growth in goats. Animal Science 1996; 65:267-273. Lockley SW, Skene DJ, Arendt J, Tabandeh H, Bird A and Defrance R. Relationship between melatonin rhythms and visual loss in the blind. J Clin Endocrinol Metab 1997; 82: 3763-3770. Middleton, B., Arendt, J., Stone, B. Complex effects of melatonin on human circadian rhythms in constant dim light. J Biol Rhythms 1997: 12:467-475 Deacon S, English J, Tate J and Arendt J. Atenolol facilitates light induced phase shifts. Neuroscience Lett 1997; 242:53-56 Barnes RG, Deacon SJ, Forbes MJ, Arendt J. Adaptation of the 6- sulphatoxymelatonin rhythm in shiftworkers on offshore oil installations during a 2 week 12-h night shift. Neurosci Lett 1998; 241: 9-12. Morgan L, Arendt J, Owens D, Folkard S, Hampton S, Deacon S, English J, Ribeiro D, Taylor K. Effects of the endogenous clock and sleep time on melatonin, insulin, glucose and lipid metabolism. Journal of Endocrinology 1998; 157: 443-451 Lockley SW, Skene DJ, Thapan K, English J, Ribeiro D, Haimov I, Hampton S, Middleton B, von Schantz M, Arendt J. Extraocular light exposure does not suppress plasma melatonin in humans. J Clin Endocrinol Metab 1998; 83: 3369-3372.

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Ribeiro DCO, Hampton SM, Morgan L, Deacon S, Arendt J. Altered postprandial responses in a simulated shift work environment. J Endocrinol 1998; 158:305-310. Arendt J. Melatonin and jet lag. (letter to Lancet, 10th Jan 1998). Barnes RG, Forbes MJ, Arendt J. Shift type and season affect adaptation of the 6-sulphatoxymelatonin rhythm in offshore oil rig workers. Neurosci Lett 1998; 252:179-182. Tabandeh H, Lockley SW, Buttery R, Skene DJ,Defrance R, Arendt J, Bird AC. Disturbance in sleep in blindness. Am J Ophthalmol 1998; 126: 707-712 Gebbie, F.E., Forsyth, I.A. and Arendt, J. Effects of maintained solstice light and temperature on reproductive activity, coat growth, plasma prolactin and melatonin in goats. J Reprod Fert 1999; 116:25-33.. Skene DJ, Lockley SW, James K, Arendt J. Correlation between urinary cortisol and 6-sulphatoxymelatonin rhythms in field studies of blind subjects. Clin Endocrinol 1999; 50:715-719. Lockley SW, Skene DJ, Arendt J. Comparison between subjective and actigraphic measurement of sleep and sleep rhythms. J Sleep Res 1999; 8:175-183 Lockley SW, Skene DJ, Butler LJ, Arendt J. Sleep and activity rhythms are related to circadian phase in the blind. Sleep 1999; 22:616-623. Lockley SW, Skene DJ, James K, Thapan, K, Wright J and Arendt J. Melatonin administration can entrain the free running circadian system of blind subjects. J Endocrinol 2000; 164:R1-R6. Baskett JJ, Wood PC, Broad JB, Duncan JR, English J, Arendt J. Melatonin in older people with age related sleep maintenance problems: a comparison with age matched normal sleepers. Sleep 2001;24:418-423. Sopowski MJ, Hampton SM, Ribeiro DCO, Morgan L, Arendt J. Postprandial triacyl glycerol responses in simulated night and day shift: gender differences. J Biol Rhythms 2001;16:272-276. Thapan K, Arendt J, Skene DJ. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol. 2001 ;535:261-7. Lund J, Arendt J, Hampton SM, English J, Morgan LM. Postprandial hormone and metabolic responses amongst shift workers in Antarctica. J Endocrinol 2001; 171: 557-564 Cockell CS, Horneck G, Retterberg P, Arendt J, Scherer K, Facius R, Gugg-Helminger A. Human exposure to ultraviolet radiation at the Antipodes - a comparison between an Antarctic (67oS) and Arctic (75oN) location. Polar Biology 2002; 25, No. 7, 492-499. Gibbs M, Hampton S, Morgan L, Arendt J. Adaptation of the circadian rhythm of 6-

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sulphatoxymelatonin to a shift schedule of seven nights followed by seven days in offshore oil installation workers. Neurosci Lett 2002; 325: 91-94 Middleton B, Stone BM, Arendt J. Human circadian phase in 12:12h, 200:<8 lux and 1000:<8 lux light-dark cycles, without scheduled sleep or activity. Neurosci Lett 2002; 329: 41-44. Middleton B., Rajaratnam S.M.W., Stone B.M., Dijk D-J., Arendt J. Hormonal response to a melatonin induced shift in sleep timing. 16th Congress of the European Sleep Research Society, Iceland, 2002. Journal of Sleep Research, 2002, 11, Suppl 1, p 154, abstr. No. 309.

Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack L, English J, Leger D, Smits MG, Williams

A, Skene DJ, von Schantz M. The 3111 Clock gene polymorphism, sleep, and circadian rhythmicity in phenotypically characterised human subjects. J Sleep Res 2002; 11: 305-312. Tripp HM, Warman GR, Arendt J. 500 μT 50 HZ Circularly polarized EMF does not acutely suppress melatonin secretion from cultured Wistar rat pineal glands. Biolelectromagnetics, 2003; 24:118-124. Hack LM, Lockley SW, Arendt J, Skene DJ. The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjects. J Biol Rhythms. 2003;18:420-9. Warman GR, Tripp HM, Warman VL, Arendt J. Acute exposure to circularly polarized 50 Hz magnetic fields of 200-300 uT does not significantly affect the timing or production of melatonin in humans. J Clin Endocrinol Metab.2003; 88:5668-73. Rajaratnam, SW, Dijk DJ, Middleton B, Stone BM, Arendt J. Artificially prolonged melatonin profile phase-shifts human circadian rhythms without altering the duration of endogenous melatonin secretion, daytime sleepiness, mood or the 24h production of reproductive hormones. J Clin Endocrinol Metab 2003; 88: 4303-9. Warman VL, Dijk D-J, Warman GR, Arendt J, Skene DJ. Phase advancing human circadian rhythms with short wavelength light. Neurosci Lett, 2003;342:37-40. Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. A length polymorphism in the circadian clock gene Per 3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep, 2003;26:413-415. Ng L, Morgan L, Arendt J. Circadian adaptation in Antarctic shiftworkers: relationship to diurnal preference, season and subjective sleep. Chronobiol Int 2003; 20: 1162-1164 Rajaratnam SMW, Middleton B, Stone BM, Arendt J, Dijk D-J. Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities. J Physiol 2004; 561:339-351.

Middleton B, Francis G, Bishop L, Luke C, Williams P, Arendt J. Sleep in different artificial

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light environments in winter at Halley Bay Antarctica (750S). Sleep 2005;28:Abstr Suppl, p.97

Revell VL, Arendt J, Terman M, Skene DJ. Short-wavelength sensitivity of the human circadian system to phase advancing light. J Biol Rhythms, 2005; 20:270-272.

Revell VL, Arendt J, Fogg LF, Skene DJ. Alerting effects of light are sensitive to very short wavelengths. Neurosci Lett 2006, 399;1-2:96-100.

Arendt J, Middleton B, Francis G, Williams P, Luke C. Sleep and circadian phase in ship’s crew. J Biol Rhythms 2006;21:214-221

Van de Walle G, Middleton B, Rajaratnam SMW, Stone BM, Thorleifsdottir B, Arendt J, Dijk DJ. Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod. J. Sleep Res. (2007) 16, 148–155

Arendt J. Does melatonin improve sleep? Efficacy of melatonin. BMJ 2006; 332: 550.

Gibbs M, Hampton S, Morgan L, Arendt J. Predicting Circadian Response to Abrupt Phase Shift: 6-Sulphatoxymelatonin Rhythms in Rotating Shift workers Offshore. J Biol Rhythms 2007; 22:368-70 letter. Paul MA, Miller JC, Gray G, Buick F, Blazeski S, Arendt J. Circadian phase delay induced by phototherapeutic devices. Aviat Space Environ Med. 2007; 78: 645-52.

Lockley SW, Dijk DJ, Kosti O, Skene DJ, Arendt J (2008) Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blind, J Sleep Res, 2008; 17.

Francis G, Bishop L, Luke C, Middleton B, Williams P, Arendt J. Sleep during the Antarctic winter: preliminary observations on changing the spectral composition of artificial light. J Sleep Res, 2008, Published Online: Jun 28 2008 6:27AM DOI: 10.1111/j.1365-2869.2008.00664.x. J Sleep Res. 2008 Sep;17(3):354-60. Thorne H, Hampton S, Morgan L, Skene DJ, Arendt J. Differences in Sleep, Light and Circadian Phase in Offshore Shiftworkers working 18:00-06:00 h and 19:00-07:00 h. Chronobiol Int, 2008, 25(2&3): 225–235. Paul MA., Miller JC, Love Ryan J, Lieberman H, Blazeski S, Arendt J. Timing Light Treatment for Eastward and Westward Travel Preparation, Chronobiol Int, 2009; 26:867 890

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Mottram V, Middleton B, Williams P, Arendt J.. The impact of bright artificial white and “blue enriched” light on sleep and circadian phase during the polar winter. J Sleep Research 2010, Aug 17th Epub ahead of print.

Paul MA, Miller JC, Gray GW, Love RJ, Lieberman HR, Arendt J. Melatonin treatment for eastward and westward travel preparation. Psychopharmacol, 2010;208:377-86. Epub 2009 Dec 15.

Thorne H, Hampton S, Morgan L, Skene DJ, Arendt J. Returning from night shift to day life; beneficial effects of light on sleep. Sleep and Biological Rhythms 2010, 8 (3), 212-221

Mottram V, Middleton B, Williams P, Arendt J. The impact of bright artificial white and 'blue-enriched' light on sleep and circadian phase during the polar winter. J Sleep Res. 2011 Mar;20(1 Pt 2):154-61. doi: 10.1111/j.1365-2869.2010.00875.x. Epub 2010 Aug 17.

Paul MA, Gray GW, Lieberman HR, Love RJ, Miller JC, Trouborst M, Arendt J. Phase advance with separate and combined melatonin and light treatment. Psychopharmacology (Berl). 2011 Mar;214(2):515-23. Epub 2010 Nov 11.

The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. Pagani L, Semenova EA, Moriggi E, Revell VL, Hack LM, Lockley SW, Arendt J, Skene DJ, Meier F, Izakovic J, Wirz-Justice A, Cajochen C, Sergeeva OJ, Cheresiz SV, Danilenko KV, Eckert A, Brown SA. PLoS One. 2010 Oct 15;5(10):e13376.

Warman GR, Pawley MD, Bolton C, Cheeseman JF, Fernando AT 3rd, Arendt J, Wirz-Justice A. Circadian-related sleep disorders and sleep medication use in the New Zealand blind population: an observational prevalence survey. PLoS One. 2011;6(7):e22073. Epub 2011 Jul 18

2) Invited Reviews, Editorials, Book Chapters and Conference proceedings (* indicates invited lecture) Beguin F. and Arendt J.: Concentration de l'acide 5-hydroxy-indole-acetique dans le liquide amniotique et maturite foetale. Gynaek. Rdsch., 14 (1974), supp.1, 39- 41. *Arendt, J. Melatonin assays in body fluids. J. Neural Transm, Suppl 13 (1978), 265-278. *Arendt, J. and M. Wilkinson: 'Melatonin' chapter of 'Methods of Hormone Radioimmunoassay', Vol. l, 2nd Edition, Editors, B.M. Jaffe and H.R. Behrman, Academic Press, New York, 1979 pp 101-119. Wirz-Justice A. and J. Arendt: Diurnal, menstrual cycle and seasonal indole rhythms in man and their modification in affective disorders. Biological Psychiatry Today (1979) Eds. J. Obiols. C. Ballus, Gonzalez-Monclus and J. Pujol. pp 294-302.

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*Arendt, J. Radioimmunoassayable melatonin: circulating patterns in man and sheep. Prog. Brain Res., 52 (1979), 249-258. *Arendt, J. Current status of assay methods of melatonin. Adv. Biosciences, 1980; 29:3-7. *Arendt, J. Melatonin, in 'Melatonin, endorphins and adrenarche', Hormone Res, 12 (1980), 178-180. Laud C, Arendt J. Melatonin and biorhythms. Adv. Biosciences, 29 (1980), 177- 182. Arendt J. Discussion in: Biological clocks in seasonal reproductive cycles : proceedings of the thirty-second symposium of the Colston Research Society, held in the University of Bristol, March-April 1980. Eds Brian K Follett; D E Follett; Colston Research Society.; University of Bristol. Lincoln, G.A., O.F.X. Almeida and J. Arendt: Role of melatonin and circadian rhythms in seasonal reproduction in rams. J. Reprod. Fert. Suppl. 30, (1981), 23-31. Vivien-Roels B. and J. Arendt: Relative roles of environmental factors, photoperiod and temperature in the control of serotonin and melatonin circadian variations in the pineal organ and plasma of the tortoise, Testudo hermanni Gmelin. Adv. Biosciences, 29 (1980), 401-406. *Arendt, J. Melatonin (?Neurohormone) (1981) In: Metabolic Disorders of the Nervous System. Progress in Neurology Series. Ed. F. Clifford-Rose. Pitman Press pp 40-48. *Arendt, J. Assay of Melatonin and other 5-methoxyindoles: current status and usefulness in physiological and clinical investigations (1981) In: The Pineal Organ, eds Oksche, A. and Pevet, P. Elsevier-North Holland, pp 247-261. *Arendt, J., Symons and Laud, C. Pineal function and photoperiod in the ewe. (1981). In: Photoperiodism and Reproduction eds. Ortavant, R., Pelletier, J. and Ravault, J-P., INRA Publ. pp. 219-229. Vivien-Roels, B. and Arendt, J. Environmental control of pineal and gonadal function in reptiles: preliminary results on the results on the relative roles of photoperiod and temperature (1981). In: Photoperiodism and Reproduction eds. Ortavant, R., Pelletier, J. and Ravault, J.P., INRA Publ. pp 273-289. Arendt, J. and Marks, V. (1982). Physiological changes underlying jet-lag. Brit. Med. J., (Regular Review), 284, 144-146. Checkley, S. and Arendt, J. Pharmacoendocrine studies of GH, PRL and melatonin in patients with affective disease (1982). In: Proceedings of the Psychoneuroendocrinology Symposium, Hamilton, Ontario, Canada, ed. G.M. Brown.

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Arendt, J. Biological Rhythms, International Medicine (review 1983) 3, 6-9. *Arendt, J. Some physiological responses and effects of the pineal indoleamine melatonin. Progress in tryptophan and serotonin research. (l984) Eds. Schossberger, H.G., Kochen, W., Linzen, B. & Steinhart, H. 259-265. Arendt, J. Mammalian pineal rhythms. Pineal Res. Rev., (1985) 3, 161-213. *Arendt, J., Symons, A.M., English, J. Factors influencing melatonin secretion in the ewe (review). (1985) Pergamon, ed. Mess, B., Ruzsas, Cs., Tima, L. and Pevet, P. In: The Pineal Gland: Current State of Pineal Research. Akademiai Kiado Budapest pp155-160. English, J., G.W. Aherne, J. Arendt. Effect of corticosteroids and melatonin on the circadian rhythm of methotrexate toxicity in the rat. Biological Rhythms and Medication, (1985) Proceedings: Pergamon. Arendt, J. The pineal hormone melatonin in seasonal and circadian rhythms. In Circadian Rhythms and the Central Nervous System, Ed. Redfern, P. (1985) Macmillan Press, U.K. Thompson, C., S.A. Checkley and J. Arendt. Circadian rhythms of melatonin and cortisol secretion during treatment with imipramine in depressed patients and normal volunteers. Biological Rhythms (1985) Ed. A. Hilaris, Academic Press, NY. Checkley, S.A., C. Thompson, C. Franey and J. Arendt. Effect of desipramine on melatonin and cortisol in normal and depressed subjects. In Circadian Rhythm and the Central Nervous System. Ed. Redfern, P. (1985). Macmillan Press U.K. *Arendt, J., C. Bojkowski, S. Folkard, C. Franey, D. Minors, J. Waterhouse, R.A. Wever, C. Wildgruber, J. Wright and V. Marks. Some effects of melatonin and the control of its secretion in man. Ciba Foundation Symposium 117, Photoperiodism, melatonin and the pineal. (1985), 266-283. Ed. Evered, D. and Clark, S. Pitman, London. Rosenthal, N.E., Sack, D.A., Jacobsen, F.M., James, S.P., Parry, B.L., Arendt, J., Tamarkin, L., Wehr, T.A. The role of melatonin in seasonal affective disorders. In: Melatonin in Humans. Eds. Wurtman, R.J. and Waldhauser, F. J. Neural Transmission Suppl. 21 (1986) 257-268. Arendt. J. Role of the pineal gland in seasonal reproductive function. Oxford Reviews of Reproductive Physiology (1986), 8, 266-320. *Arendt, J. Assay of melatonin and its metabolites: results in normal and unusual environments. In: Melatonin in Humans. Eds. Wurtman, R.J. and Waldhauser, F. J. Neural Transm, Suppl. 21 (1986) 257-268. Checkley, S.A., Corn, T.H., Glass, I.B., Thompson, C., Franey, C. and Arendt, J. Neuroendocrine and other studies of the mechanism of anti-depressant action of desipramine. Ciba Foundation Symposium 123, (1986), Pitman:London.

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Arendt, J. and Broadway J. Light and melatonin as zeitgebers in man. Int J Chronobiol 1987; 4:273-282. *Arendt, J., Aldhous, M., Bojkowski, C., English, J., Franey, C., Poulton, A.L. and Skene, D. Investigations of pineal function in man. Proceedings of the Symposium - 'The pineal gland: its physiological and pharmacological role'. Erice, Sicily, 1986. Advances in Pineal Research (1987) 2, 223-230. Eds: Reiter, R.J. and Fraschini, F. John Libbey & Co Limited:UK. *Arendt, J., Symons, A.M., English, J. and Poulton, A.L. Melatonin and the seasonal breeding cycle in sheep. Proceedings of the Symposium 'The pineal gland: its physiological and pharmacological role'. Erice, Sicily, 1986. Advances in Pineal Research (1987) 2, 240-245. Arendt, J. Manipulation of rhythms in health and disease: current concepts and perspectives. Annals of Clinical Biochemistry 24, Suppl. 1 (1987) 51-28. Broadway, J. and Arendt, J. Human melatonin responses to season and bright light in Antarctica. International Congress on Circumpolar Health. Umea, Sweden, 1987. Proceedings. *Arendt J, Aldhous ME., Bojkowski C, English J, Franey C. and Skene DJ. Effects and metabolism of melatonin in humans. Fundamentals and Clinics in Pineal Research. Serono Symposia Publications. Raven Press, New York, Vol. 44, pp. 305- 310, (1987). Arendt, J. and Aldhous, M. Further evalation of the treatment of jet-lag by melatonin: a double-blind crossover study. Annual Review of Chronopharmacology (1988) 5, 53-56. Arendt, J. Melatonin and the human circadian system. In: Melatonin, Clinical Perspectives. Eds: Thompson, C., Miles, A. and Philbrick, D. Oxford University Press. 1988. pp. 43-61. *Arendt, J., Symons, A.M., English, J., Poulton, A.L. and Tobler, I. How does melatonin control seasonal reproductive cycles? Reproduction, Nutrition, Development (1988) 28, 387-397. Arendt, J. Melatonin (review) Clinical Endocrinology (1988) 29, 205-229. Arendt, J., Broadway, J., English, J.E., Kemp, M., Poulton, A.L. and Symons, A.M. Pineal and photoperiodicity: practical aspects. In: Trends in Chronbiology. Advances in the Biosciences. 73 (1988) 137-148. Pergamon, Oxford, UK. Arendt, J., Broadway, J., Folkard, S. and Marks, M. The effects of light on mood and melatonin in normal subjects. In: Seasonal Affective Disorder. Eds: Thompson, C. and Silverstone, T. CNS (Clinical Neuroscience) publishers,London,1989. Skene, D.J., Aldhous, M. and Arendt, J. Melatonin, jet-lag and the sleep-wake cycle. Proceedings of the European Sleep Congress, Jerusalem, Sleep '88 ,Ed.J.Horne, pp 39- 41, Gustav Fischer Verlag, Stuttgart, NY, 1989.

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Arendt, J. The Pineal Gland. In :Biological Rhythms in Clinical Practice, editors Arendt, J., Minors, D.S. Waterhouse, J. Butterworths Scientific, (1989). Claustrat, B., Le Bars, D., Brun, J., Thivolle, P., Mallo, C., Arendt, J. and Chazot, G. Plasma and brain pharmacokinetic studies in humans after intravenous administration of cold or 11C labelled melatonin. Proceedings: Satellite Symposium on the Pineal Grand, 8th International Congress of Endocrinology, Hong Kong, July 1988, Advances in Pineal Research 3 (1989) 305-310. Arendt, J. Melatonin - a new probe in psychiatric investigation. British Journal of Psychiatry, (1989), 155, 585-590. Sarrafzadeh, A., Wirz-Justice, A., Arendt, J., & English, J. (1990) Melatonin stabilises sleep onset in a blind man. In: J.A. Horne (Ed.) SLEEP '90. Pontenagel Press, Dortmund, pp. 51-54. Deveson, S., Arendt, J. and Forsyth,I.A. The effects of melatonin on seasonal breeding in goats. Goat Veterinary Society Journal,(1990),11,45-51. *Arendt, J. Melatonin and rhythmic functions in mammals: therapeutic and commercial potential. Annual Reviews of Chronopharmacology, (1990),6,137-153. *Arendt, J. Potential therapeutic use of melatonin in biological rhythm disturbance. Proceedings "Stress, biological rhythms and psychiatric disorders", Proceedings,3rd International Symposium (1990), Ed. H.G.M. Westenberg. Houten:Medidact.III, The Netherlands. *Arendt, J. Melatonin as a marker rhythm in psychiatry. Proceedings, Association of Clinical Biochemists, National Meeting, (1990), Annals of Clinical Biochemistry, Suppl. pp 6-7, Eds. S.Martin, S.Halloran. *Forsyth, I.A.,Deveson, S. and Arendt, J. The manipulation of breeding season in goats.Proceedings of the Satellite Synposium on The Pineal Gland, International Neuro chemistry Congress, Sydney,Australia, eds Foldes,A. and Reiter,R.J., Advances in Pineal Research, (1991), 6, 217-223. Makkison, I. and Arendt, J. Melatonin secretion on two different Antarctic Bases (68oS and 75oS). Proceedings of the 7th meeting of the European Society for Chronobiology, Marburg, Germany,1991, Journal of Interdisciplinary Cycle Research, (1991), 22, 149-150. Midwinter, M.J. and Arendt, J. Adaptation of the melatonin rhythm following night shift work in Antarctica. Proceedings of the 7th meeting of the European Society for Chronobiology, Marburg,Germany, 1991, Journal of Interdisciplinary Cycle Research, (1991), 22, 156. Aldhous, M.E. and Arendt, J. Melatonin rhythms and the sleep wake cycle in blind subjects.Proceedings of the 7th meeting of the European Society for Chronobiology, Marburg,Germany, 1991, Journal of Interdisciplinary Cycle Research, (1991), 22, 84-85. *Arendt, J. Melatonin in humans: jet-lag and after. Proceedings of the European Pineal Society,

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Guildford, 1990. Advances in Pineal Research, (1991), 5, 299-303. Eds.Arendt,J. and Pevet,P. Aldhous, M.E. and Arendt, J. Assessment of melatonin rhythms and the sleep wake cycle in blind subjects. Proceedings of the European Pineal Society, Guildford, 1990.Advances in Pineal Research, (1991), 5, 307-311. Eds.Arendt,J. and Pevet,P. Deveson, S.,Arendt, J. and Forsyth,I.A. Prepartum light treatment delays puberty in goats born in autumn. Proceedings of the European Pineal Society, Guildford, 1990.Advances in Pineal Research,(1991),5,233-236. Eds.Arendt,J. and Pevet,P. *Deveson, S., Arendt, J. and Forsyth, I. Role of the pineal and melatonin rhythms on reproductive performance in female domestic ungulates. Animal Reproduction Science, (1992), 30,113-134. *Arendt, J. Significance of melatonin to chronobiology: immunological correlations. Proceedings of the Nato Workshop: Role of melatonin and pineal peptides in Neuroimmunomodulation, Erice, Sicily, 1991. NATO ASI series, eds Fraschini,F. and Reiter,R.J., Plenum Press,NY, (1992), 281-292. Arendt, J. The Pineal. In: Biological Rhythms in Clinical and Laboratory Medicine. Eds.Y.Touitou and E.Haus, Springer-Verlag,Heidelberg, NY, (1992), 348-363. *Arendt, J., Deveson, S., Folkard, S., Totterdell, P., and English, J. Use of melatonin in circadian rhythm disturbance associated with jet-lag and shift work. Proceeedings of the 8th Meeting of the European Society of Chronobiology. Journal of Interdisciplinary Cycle Research, 23 (1992) 156-158. Ross, J., Haston, W. and Arendt, J. Use of red and white light to adapt to phasae shift in Antarctica.Proceeedings of the 8th Meeting of the European Society of Chronobiology. Journal of Interdisciplinary Cycle Research, 23 (1992) 159-160. *Arendt, J. Some effects of light and melatonin on human rhythms. In: Light and Biological Rhythms in Man, Ed L. Wetterberg, Vol 63, Wenner-Gren International Series, Neuroscience, (1993), Pergamon Press, Oxford, pp 203-215. Vignau,J., Dahlitz,M., Parkes,J.D., Arendt, J., English,J., Minors,D. and Waterhouse,J. Biological rhythms and sleep disorders in man: the delayed sleep phase syndrome. In: Light and Biological Rhythms in Man ed L.Wetterberg, Vol 63 Wenner-Gren International Series, Neuroscience, (1993), Pergamon Press, Oxford, pp 261-271. Deveson, S., Deacon, S., Arendt, J., Totterdell, P. and English, J. Simulation of circadian rhythm disturbance associated with jet-lag and shift-work using moderately bright light. Proceedings of the Symposium: Melatonin and the Pineal Gland, fom Basic Science to Clinical Application, Satellite Symposium of the IXth International Congress of Endocrinology, September, 1992, Paris, France, eds Touitou,Y., Arendt, J. and Pevet,P., Excerpta Medica, Elsevier Science Publishers B.V., Amsterdam, (1993), pp 229- 231.

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Ross, J., Haston, W. and Arendt, J. Use of white and red light treatment to adapt to phase shift in Antarctica (Halley Base, 750S). Proceedings of the Symposium: Melatonin and the Pineal Gland, fom Basic Science to Clinical Application, Satellite Symposium of the IXth International Congress of Endocrinology, September, 1992, Paris, France, eds Touitou,Y., Arendt, J. and Pevet,P., Excerpta Medica, Elsevier Science Publishers B.V., Amsterdam (1993), 233-234. Deacon, S.J., Arendt, J. and English, J. Posture: a possible masking factor of the melatonin circadian rhythm. Proceedings of the Symposium: Melatonin and the Pineal Gland, fom Basic Science to Clinical Application, Satellite Symposium of the IXth International Congress of Endocrinology, September, 1992, Paris, France, eds Touitou,Y., Arendt,J.and Pevet,P.,Excerpta Medica, Elsevier Science Publishers B.V., Amsterdam (1993), 387-390. Gebbie, F.E., Arendt, J. and Forsyth, I.A. Oestrous cyclicity and coat growth in goats: effect of melatonin or bromocriptine. Proceedings of the Symposium: Melatonin and the Pineal Gland, fom Basic Science to Clinical Application, Satellite Symposium of the IXth International Congress of Endocrinology, September, 1992, Paris, France, eds Touitou,Y., Arendt, J. and Pevet,P., Excerpta Medica, Elsevier Science PublishersB.V., Amsterdam (1993), 251-254. *Arendt, J. Use of melatonin in circadian rhythm disturbances. Proceedings of a Symposium to celebrate the life and works of Professor Merton Sandler on the occasion of his retirement. Biogenic Amines, 9 (1993) 469-471. Arendt, J. The Pineal Gland: Basic Physiology and Clinical Implications. De Groot: Endocrinology, 3rd Edition, W.B.Saunders and Co. Philadelphia, (1994), Ch 27, pp 432- 444. *Arendt, J. Investigations on the use of light and melatonin for alleviation of problems related to jetlag and shift work. In: Biologic Effects of Light; Proceedings of the A. Rikli- Symposium, Basle, Switzerland, June 3-5, 1993. Eds: Jung, E.G. and Holick, M. (1994), Walter de Gruyter and Co., Berlin, pp 219-227. Arendt, J. Clinical perspectives for melatonin and its agonists. (Editorial) Biological Psychiatry, (1994), 35, 1-2. Deacon, S. and Arendt, J. Decrements in performance and sleep in response to a phase-shifting light stimulus (1200 lux) at night. Proceedings 9th Meeting of the European Society for Chronobiology, Bath, UK, September 1993. Biological Rhythm Research, 24 (1994) 264-266. Middleton, B., Arendt, J. and Stone, B. Melatonin, core temperature and activity rhythms in constant dim light. Proceedings 9th Meeting of the European Society for Chronobiology, Bath, UK, September 1993. Biological Rhythm Research, 24 (1994) 272-275. *Gebbie, F.E., Forsyth, I.A. and Arendt, J. Effects of melatonin, bromocriptine and altered light/temperature patterns on coat growth in dairy goats. Hormonal Control of Fibre Growth and Shedding, Proceedings of a European Workshop, Toulouse, France, 13-14th December, 1993, eds Laker, J.P. and Allain, D. European Fine Fibre Network, Occasional Publication, 2 (1994) 97-105.

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*Arendt, J. Human responses to light and melatonin. Proceedings of the European Pineal Society, Copenhagen, July 1993. Advances in Pineal Research, Eds Moller, M., and Pevet, P. John Libby and Co. London, 1994, pp 439-443. Deacon, S. and Arendt, J. Phase shifts in melatonin and alertness rhythms after treatment with moderately bright light at night: melatonin response in plasma, urine and saliva. European Pineal Society, Copenhagen, July 1993. Eds Moller, M., and Pevet, P. John Libby and Co., London, 1994. *Arendt, J. Significance of melatonin in humans. Proceedings of the NATO Workshop on the Pineal Gland, Erice Sicily, 1995, Plenum Press. *Arendt, J., Deacon, S., English, J., Hampton, S. and Morgan, L. Melatonin and adjustment to phase shift. Work Hours, Sleepiness and Accidents, Proceedings of the International Workshop, Karolinska Institute, Stockholm, September 1994, Journal of Sleep Research, 1995, 4 (Suppl 2), 74-79. Wirz-Justice, A., Kraeuchi, K., Brunner, D.P., Graw, P., Haug, H.-J., Leonhardt, G., Sarrafzadeh, A., English, J. and Arendt, J. Circadian rhythms and sleep regulation in seasonal affective disorder. In: Rhythms, Behaviour and mood. Proceedings of the Festschrift for Rudi van den Hoofdakker, Acta Neuropsychiatrica, 7/No 2(1995) 41-44. Deacon, S., Skene, D. and Arendt, J. Use of light and/or melatonin in adaptation to phase shifts. In: Biologic Effects of Light 1995, Proceedings of a Symposium, Atlanta, USA, 9-11 October 1995, eds. M.F. Holick and E.G. Jung, Walter de Gruyter, Berlin, 1996, pp. 398-405. Arendt, J. The pineal circadian rhythms and photoperiodism. In: Handbook of Experimental Pharmacology, "Physiology and Pharmacology of Biological Rhythms', eds. Redfern, P. and Lemmer, B. Vol 125, Springer-Verlag, Berlin-Heidelberg-New York, 1997; pp 375-404.. Arendt, J. and Deacon, S. Treatment of circadian rhythm disorders - melatonin. Chronobiology International 1997; 14: 185-204. Skene DJ, Lockley SW, Tabandeh H, DeFrance R, Bird AC, Arendt J. Visual Pathology and Human Circadian Rhythms. In: Webb SM, Puig-Domingo M, Moller M, Pevet P ed. Pineal Update. Westbury, NY, USA: PJD Publications Ltd, 1997, pp349-353. Skene, D.J., Deacon, S. and Arendt, J. Use of melatonin in circadian rhythm disorders and following phase shifts. Acta Neurobiologiae Experimentalis 56 (1995) 359-362. Arendt J. Melatonin. British Medical Journal, 1996; 312:1242-1243 Arendt J. Sleep Science: Integrating basic research and clinical practice. Melatonin. Karger Monographs in Clinical Neuroscience, Ed W. Schwartz, Karger, Basel, Switzerland. 1997, pp 196-228. Arendt J, Deacon S. Treatment of circadian rhythm disorders: melatonin. Review Chronobiology

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International, 1997; 14:185-204. Skene, D.J., Lockley, S.W., Tabandeh, H., Defrance, R., Bird, A.C. and Arendt, J. Visual pathology and human circadian rhythms. In: Pineal Gland Update:1996, From molecular mechanisms to clinical implications, eds SM Webb, M Puig-Domingo, M Moller, P Pevet, PJD Publications Ltd, New York, USA, 1997, pp 349-353. Arendt J. Biological rhythms: the science of chronobiology. Journal of the Royal College of Physicians, 1998; 32:27-35. *Arendt J, Deacon S, Morgan L, Hampton S, Folkard S, Owens D, Ribeiro D. Disordered rhythms: strategies for treatment and their relation to pancreatic and metabolic function. In 'Physiology, Stress and Malnutrition, eds Kinney JM and Tucker H, Lippincott-Raven, New York,1997, pp 79-94. Arendt J, Skene DJ, Middleton B, Lockley SW, Deacon S. Efficacy of melatonin treatment in jet lag, shift work and blindness. J Biol Rhythms 1997; 12: 604-618. Arendt J. Safety of melatonin in long term use(?). J Biol Rhythms 1997; 12: 673-682. Arendt J. Complex effects of melatonin. Medicographia 1998; 20:120-127. Arendt J. Complex effects of melatonin. Therapie 1998, 53: (reprinted with permission). Arendt J. Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology. Reviews of Reproduction 3;1998:13-22. Skene, DJ, Lockley SW, Arendt J. Melatonin and Circadian Sleep Disorders. Farmakoterapia W Psytchiatrii I Neurologii 1998;1:93-102 *Arendt J. Jet lag, night shift, blindness and melatonin. Transactions of The Medical Society of London, 1999;114:7-9. Lockley, S.W., Skene, D.J. and Arendt, J. Changes in sleep in relation to circadian phase in the blind. In: Biological Clocks. Mechanisms and Applications, Excerpta Medica International Congress Series (ICS) ed. Y.Touitou, Elsevier, Amsterdam, 1998, pp. 247-252. Hampton, S, Ribeiro, D, Deacon, S, Morgan, L and Arendt, J. Altered postprandial responses due to meal composition in simulated shift work, in: Touitou, Y (Ed.) Biological Clocks: Mechanisms and Applications, Elsevier: 1999, pp. 423-426. Skene, D.J., Lockley, S.W. and Arendt, J. Use of melatonin in the treatment of phase shift and sleep disorders. In: Tryptophan, Serotonin and Melatonin: Basic Aspects and Applications, eds. G. Huether, W. Kochen, T.J. Simat and H. Steinhart, Plenum Press, London, 1999. Skene, D.J., Lockley, S.W. and Arendt, J. Light perception and melatonin rhythms in the blind. In: Biologic Effects of Light 1998, Proceedings of a Symposium, Basel, Switzerland, 1-3 November

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1998, eds. M.F. Holick and E.G. Jung, Walter de Gruyter, Berlin, 1999, pp. 375- 381. Lockley, S.W., Skene, D.J., Thapan, K., English, J., Ribeiro, D., von Schantz, M. and Arendt, J. Extraocular light exposure does not suppress plasma melatonin in humans. In: Biologic Effects of Light 1998, Proceedings of a Symposium, Basel, Switzerland, 1-3 November 1998, eds. M.F. Holick and E.G. Jung, Walter de Gruyter, Berlin, 1999, pp. 401-406. *Arendt, J, Skene, DJ; Lockley, S; Middleton, B; (1998). Effects of Melatonin on Human Circadian Rhythms. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Invited Symposium. Available at URL http://www.mcmaster.ca/inabis98/brown/arendt0880/index.html *Skene DJ, Lockley SW, Arendt J. Melatonin in circadian sleep disorders in the blind. Proceedings of the NATO Workshop, Erice, Sicily, 1998, in Biological Signals and Receptors, 1998;8:90-95. Haimov I, Arendt J. The prevention and treatment of jet lag. Sleep Medicine Reviews, 1999;3: 229-240. Waterhouse J, Akerstedt T, Lennernas M, Arendt J. Chronobiology and Nutrition: internal and external factors. Canadian Journal of Diabetes Care 1999; 23 suppl 2, 82-88. Arendt J, Middleton B, Stone B, Skene D. Complex effects of melatonin- evidence for photoperiodic responses in humans? Sleep 1999; 22: 625-635. *Arendt J. Is Melatonin a photoperiodic signal in humans? In: Melatonin after Four Decades, Olcese J. (ed), Kluwer Academic/Plenum Publishers, New York, 2000: 417-423. Arendt J. Melatonin, sleep and circadian rhythms. Editorial. The New England Journal of Medicine, 2000; 343:1114-1116. Arendt J, Stone B, Skene DJ. Jet lag and sleep disruption. In: Principles and Practice of Sleep Medicine (Third Edition) Turek F. Section Ed, Kryger M., Roth T., Dement WC, (eds), WB Saunders and Co. Philadelphia, 2000: 591-599. Arendt J. Jet-lag and shift work: (2). Therapeutic use of melatonin. J R Soc Med. 1999 ;92:402-5. Arendt J. The Biological Clock. In: The Body Clock. Oxford Companion to the Body. Ed C.Blakemore, OUP, 2001. Arendt J. The Pineal Gland. In: The Body Clock. Oxford Companion to the Body. Ed C. Blakemore, OUP, 2001. Rajaratnam S. and Arendt J. Health in a 24-h society. The Lancet 2001;358:999-1005 *Arendt J. Importance and relevance of melatonin to human biological rhythms. Invited, review. Proceedings of the European Pineal and Biological Rhythms Society, Aberdeen, 2002. J Neuroendocrinol, 2003; 15: 427-431.

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Warman GR, Tripp HM, Warman VL, Arendt J. Circadian neuroendocrine physiology and electromagnetic field studies: precautions and complexities. Radiat Prot Dosimetry. 2003;106:369-73. Morgan L, Hampton S, Gibbs M, Arendt J. Circadian aspects of postprandial metabolism. Chronobiol Int 2003;20:795-808. Arendt J. The Pineal Gland: Basic Physiology and Clinical Implications. In: DeGroot LJ, Jameson JL. Endocrinology, 5th Edition, WB Saunders & Co., Philadelphia, !st ed, 2004, Ch 31. Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep Medicine Reviews, 2004; 9:25-39. Arendt J. Melatonin. In: Encyclopaedia of Endocrine Diseases. Vol. 3. Editor in Chief, Martini, L. Section Editor, Sizonenko, PC. Elsevier, 2004, pp 228-237.

Arendt J, Stone B, Skene D. Sleep disruption in jet lag and other circadian rhythm disturbances. Principles and Practice of Sleep Medicine, 4th Edition, Eds Kryger, Roth, Dement, WB Saunders and Co. Philadelphia, 2005, Ch 55, pp 659-672. ISBN 1416003207. Arendt J. The Pineal Gland and Pineal Tumours. In: Endotext.org, online endocrinology textbook, updated yearly, Section Editors GM Besser & A. Grossman, 2005, Ch 15. Arendt J. Melatonin: characteristics, concerns and prospects. J Biol Rhythms, 2005, 20:291-303.

Arendt J. Melatonin in humans: it's about time. J Neuroendocrinol. 2005 ;17:537-8. Arendt J. Melatonin, sleep and the biological clock. Physiology News 2005 ;61:22-23. *Arendt J. Melatonin and human rhythms. Proceedings of the Scharrer Symposium, European Biological Rhythms Society, Frankfurt, September 2005. Chronobiol Int 2006;23 : 21-37. Skene DJ, Arendt J. Human circadian rhythms: physiological and therapeutic relevance of light and melatonin. Ann Clin Biochem 2006; 43: 344–353. Skene DJ, Arendt J. Circadian rhythm sleep disorders in the blind and their treatment with melatonin. Sleep Medicine. 2007; 8: 651-5. Epub 2007. Review. Lockley SW, Arendt J, Skene DJ. Visual impairment and circadian rhythm disorders. Dialogues Clin Neurosci. 2007; 9: 301-14. Review. Arendt J, Van Someren E, Appleton R, Skene D, Akerstedt T. Clinical update: Melatonin and sleep disorders. Clinical Medicine, 2008; 8: 381-383. Arendt J, Skene DJ. Circadian rhythm sleep disorder: Special considerations for treatment: melatonin and light. Handbook of Sleep Disorders, 2nd Edition, Ed CA Kushida, Informa Health care, 2009.

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Arendt J. Managing jet lag: some of the problems and possible new solutions, Sleep Medicine Reviews, 2009; 13: 249-256 Arendt J, Rajaratnam SW. Melatonin and its agonists - an update. Br J Psychiatry. 2008 Oct;193(4):267-9. Arendt J. Melatonin. In: Binder, M.D, Hirokawa, N, Windhorst, U (eds). Encyclopedia of Neuroscience. Springer, Berlin Heidelberg New York, 2008. Arendt J. Melatonin Receptors. In: Binder, M.D, Hirokawa, N, Windhorst, U (eds). Encyclopedia of Neuroscience. Springer, Berlin Heidelberg New York, 2008. Zawilska JB, Skene DJ, Arendt J. Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacol Rep. 2009 May-Jun;61(3):383-410.

Arendt J. Shift work: coping with the biological clock. Occ Med, 2009; Occupational Medicine 2010 60(1):10-20

Arendt J, Cox TM. The pineal gland and melatonin. Oxford Textbook of Medicine. 2011 In press.

Sletten TL, Arendt J. Circadian Rhythm Disorders III: Jet lag. In: Morin, C. M. and Espie, C. (2012). Historical Landmarks and Current Status of Sleep Research and Practice. In C. M. Morin and C. Espie (Eds.), The Oxford Handbook of Sleep and Sleep Disorders. New York: Oxford University Press. 3) Books written Melatonin and the Mammalian Pineal Gland. Arendt, J. Chapman Hall, London, December, 1995. Second Edition in preparation. 4) Books edited Biological Rhythms in Clinical Practice, editors Arendt, J., Minors, D.S. Waterhouse, J. Butterworths Scientific, London (1989). Advances in Pineal Research, editors Arendt, J. and Pevet,P. John Libbey, London, (1991). Melatonin and the Pineal Gland, fom Basic Science to Clinical Application, editors Touitou Y, Arendt J. and Pevet P, Excerpta Medica, Elsevier Science Publishers B.V., Amsterdam, (1993).

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5) Other publications including HSE Research Reports Arendt, J. and Marks, V. Can melatonin alleviate jet-lag? Brit. Med. J. (1983) 287, 426 (letter). Arendt, J. The pineal: A gland that measures time. New Scientist, (1985) July 25th, 36- 39. Arendt, J. The pineal - a gland whose time has come. MRC News, June 1986. Arendt, J. Chronobiology of melatonin, ISI Atlas of Science (1987) 1, 257-261. Collin, J.P., Arendt, J. and Gern, N.A. Le 'troisieme oeil'. La Recherche (1988) 203, 1154-1165. Arendt, J. Chrononutrition. Food Technology International-Europe (1989). Sterling Publications Ltd. London, UK. pp. 25-28. Arendt, J. Biological clocks in man: research on the function of the pineal gland could hold the key to understanding jet-lag and winter depression. AFRC News, July 1989, p.v (Royal Show Supplement). Arendt,J. The Third Eye and the Biological Clock. Inaugural Address, 28th November, (1990), University of Surrey publications. Arendt, J. Seasonal Affective Disorder. In: The Biochemist, December 1995. Arendt, J. Melatonin Research: Miracle or Myth. Orgyn, PMSI Bugamor, The Netherlands, 1997, VII (3), 37-40. Arendt J. Measuring melatonin: why and how? ACB News Sheet, 1997. Arendt J, Lewy AJ, Cassone V, Duncan M, Morin L. Shedding light on melatonin. Internet debate published on the net by HMS Beagle, 1997. http://biomednet.com/hmsbeagle/1997/20/cutedge/overview.htm Arendt J, Czeisler CA, Dawson D, Dijk DJ, Haimov I, Lavie P, Lewy AJ, Parkes JD, Wirz-Justice A, Zhadnova I, In what circumstances is melatonin a useful sleep therapy? Refereed Consensus Statement from a Symposium (Coordinator J Arendt) World Federation of Sleep Research Societies, Dresden, Germany, 5-9th October, 1999. J Sleep Res 2000; 9:397-398. Haraldsson PO, Åkerstedt T, Gillberg M, Kecklund G, Jerker H, Landström U, Englund L, Arendt J, Cassel W, Dinges D, Findley L, Folkard S, George C, Guilleminault C, Hack M, Heartly L, Horne J, Krieger J, Nicholson A, Pack A, Parkes JD, Partinen M, Philip P, Reyner L, Rosekind M, Samel A, Spencer M, Zulley J. Refereed Consensus statement from “The Sleepy Driver and Pilot” conference, Stockholm, 26-27th May 2000: Fatigue and accidents in transport operations. J Sleep Res 2000; 9:395.

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Arendt J. Review of ‘Seasonal Affective Disorder: Practice and Research’ Editors T. Partonen and A. Magnussen. Nature 2002; 415: 838-839. Gibbs M, Hampton SH, Morgan L, Arendt J. Circadian adaptation to shift change in offshore shift workers. HSE Offshore Research Report, 2001. http://www.hse.gov.uk/research/otopdf/2001/oto01041.pdf. Gibbs M, Morgan L, Hampton S, Arendt J. Circadian adaptation, dietary intake and metabolic responses in offshore shift workers. HSE Offshore research Report, 2000. http://www.hse.gov.uk/RESEARCH/otopdf/2000/oto00126.pdf. Gibbs M, Hampton SH, Morgan L, Arendt J. Effect of shift schedule on offshore shift workers’ circadian rhythms and health, 2004. http://www.hse.gov.uk/research/rrpdf/rr318.pdf. Now http://www.hse.gov.uk/research/rrhtm/rr318.htm IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 98 (2010), Painting, Firefighting, and Shiftwork (expert advisor) Power Frequency Electromagnetic Fields, Melatonin and the Risk of Breast Cancer (RCE-1). Documents of the HPA, RCE Series. Report of an independent Advisory Group on Non-ionising Radiation. February 2006 (Advisory group member and contributor).

Obituaries Arendt J. Aaron Lerner, who discovered melatonin. Journal of Pineal Research 2007; 43: 106–107. Arendt J. A tribute to Aaron Lerner. Chronobiol Int. 2007; 24: 383-5.

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