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In-clinic blood chemistry analysis by

Panels to use from9PT10V Pre-Surgical 10V

PT10V Comprehensive 16V

PT10V Liver 11V

PT10V Kidney 8V

PT10V Electrolyte Test 4V

PT10V Liver monitoring 3V

PT10V Kidney monitoring 4V

PT10V Large Animal 14V

PT10V Diabetes 4V

PT10V Diabetes 4V allows for effective monitoring of diabetetic patients in conjunction with insulin therapy.

PT10V CRP 1V picks up on a systemic inflammation and should be used as a rule-in or rule-out tool for inflammatory disease.

GLU TRIGFRUC CHOL CRP

Coming soonNew!PT10V Diabetes 4V PT10V CRP 1V

PT10VDiabetes 4V

In-Vitro DiagnosticsClinical Leaflet

Benefits of PT10V Diabetes 4V

• Diagnosis and monitoring of diabetes mellitus

• Ruling out stress-induced hyperglycemia

• Monitoring diabetic patients in conjuction with insulin therapy

• Monitoring patient’s diet, followd by addressing obesity and weight control

PT10V Diabetes 4V

PT10V Diabetes 4V Clinical Leaflet 1.0 180823-EN

For more informationFor more information about PT10V, visit vet.samsunghealthcare.com

www.scilvet.com www.scilvet.com

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Diabetes is more commonDiabetes mellitus (DM), or diabetes is a common disease encountered in dogs and cats.

In recent survey, diabetes mellitus occurs in roughly 1 in 200 cats and 1 in 300 dogs.

The diagnosis is often preceded or accompanied by obesity.

What is Diabetes?Diabetes mellitus is an absolute or relative deficiency of the hormone insulin.

Insulin is synthesized and released from beta cells in the pancreatic islets.

Insulin assists with cellular uptake of glucose from the bloodstream into the cells

of the body for energy. In diabetics, glucose isn't transported into the cells and there is

not enough energy for the cells to function normally.

■ Canine diabetes mellitus

• Most diabetic dogs are suspected of having type I DM, characterized by permanent

inability to produce insulin and often required by exogenous insulin administration.

• Most dogs are diagnosed at roughly 7 - 10 years of age.

• Female dogs are at increased risk, regardless of neuter status, than male dogs.

• Neutered male dogs are at greater risk than intact male dogs.

■ Feline diabetes mellitus

• Most diabetic cats have type II DM, characterized by β-cell dysfunction and peripheral

insulin resistance.

• Most cats are diagnosed at > 6 years of age.

• Neutered male cats are at greater risk than female cats.

■ Common laboratory abnormalities are

• Hyperglycemia

√ Caution: When interpreting a high blood glucose in cats and dogs (lower

frequency than cats), it is important to discern between stress hyperglycemia and

hyperglycemia that needs treatment.

• Hypercholesterolemia

• Hypertriglycedemia

• Mild anemia

• Mild ALT and ALP elevations

Common concurrentdiseases/risks

• Obesity

• Hypercholesterolemia

• Hypertriglycedemia

• Hyperthyroidism

• Hypothyroidisam

• Hypoadrenocortism

• Infection

(ex: urinary tract infection)

• Pancreatitis

• Kidney disease

• Pregnancy/diestrus

Diabetes prevalence

Get Results

Step 1 Step 2

Step 3Inject Sample* Plasma or Serum

Insert Cartridge

70 µl

CARE for our companionsPT10V is a portable veterinary clinical chemistry analyzer that meets the needs of

veterinary clinics while providing a smart solution to improve efficiency.

CAREwith

PT10V

C ompact A ccessible

E asy to useR eliable

Cartridge Configuration*Calculated values

Model Code Panel Test Analytes

IVR-PT01V PT10V Pre-surgical 10V ALB, ALP, ALT, BUN, CREA, GLU, TP, A/G ratio*, B/C ratio*, GLOB*

IVR-PT02V PT10V Comprehensive 16VALB, ALP, ALT, AMY, BUN, Ca, CHOL, CREA, GLU, PHOS, TBIL, TP, TRIG A/G ratio*, B/C ratio*, GLOB*

IVR-PT03V PT10V Liver 11V ALB, ALP, ALT, AST, BUN, GGT, GLU, TBIL, TP, A/G ratio*, GLOB*

IVR-PT04V PT10V Kidney 8V ALB, AMY, BUN, Ca, CREA, GLU, PHOS, B/C ratio*

IVR-PT05V PT10V Electrolyte Test 4V Na, K, Cl, Na/K ratio*

IVR-PT07V PT10V Liver monitoring 3V ALT, GGT, TBIL

IVR-PT08V PT10V Kidney monitoring 4V BUN, CREA, PHOS, B/C ratio*

IVR-PT09V PT10V Large Animal 14V ALB, ALP, AST, BUN, Ca, CK, CREA, GGT, GLU, TBIL, TP, A/G ratio*B/C ratio*, GLOB*

IVR-PT10V PT10V Diabetes 4V CHOL, FRUC, GLU, TRIG New

1 in 200

Cats

1 in 300

Dogs

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3 4

Level Mean SD Total CVNormal 312 μM 7.0 2.2%

Abnormal 537 μM 11.8 2.2%

How much reliable is PT10V Diabetes 4V testing?Fructosamine test performance and reliability

■ Introduction

Fructosamine (FRUC) is a stable complex of blood glucose and proteins produced by an irreversible glycosylation of proteins. FRUC level assesses the average blood glucose concentration over the previous 1-2 weeks, and is extremely helpful in long-term monitoring of diabetic dogs and cats. The PT10V Diabetes 4V provides four different tests of GLU, FRUC, CHOL, and TRIG to manage the increasing diabetic cases in veterinary practices.

PT10V Diabetes 4V

■ Conclusion

FRUC test in PT10V Diabetes 4V makes a highly accurate result when FRUC concentration in canine and feline sample is measured.

[Table 1] Precision results

[Fig. 1] Method comparison for canine samples

[Fig. 2] Method comparison for feline samples

■ Precision

Material and methods: Precision test was performed by using quality control materials at two different concentrations, Roche Precinorm and Roche Precipath, based on a standard guideline (CLSI EP5-A2). There were 2 replica on a run and 2 runs on a day during 20 days (80 replica in total).

Results: Total precision was calculated by a statistical SW, Analyse-It®. As shown In Table 1, total precisions at both levels are less than 3.0%.

■ Method comparison

Material and methods: Roche P-modular was used as a reference laboratory method, and 4 PT10V devices were used for inclusion of device variation. Canine and feline sera were collected and tested by the reference method and PT10V devices simultaneously. Method comparison was evaluated by a standard guideline (CLSI EP09-A2). Linear regression was done by Passing-Bablok regression, and the bias estimation by Bland-Altman analysis.

Results: The Passing-Bablok regressions of canine and feline samples are shown in Fig. 1 and Fig. 2 respectively. Pearson’s correlation coefficient (R) is 0.9868 for canine samples (N = 104), and 0.9900 for feline samples (N = 78). The mean bias is 0.2% for canine samples, and -0.2% for feline samples.

Therefore, FRUC test of PT10V Diabetes 4V is compa-rable to the reference method, Roche P-modular.

What is PT10V Diabetes 4V testing?When a dog or a cat presents diabetes mellitus with clinical signs of polyuria (PU),

polydipsia (PD), polyphagia (PP) and weight loss, veterinarians prefer to use blood glucose

spot-testing or a glucose curve, fructosamine testing, or a combination of these. In

addition, the veterinarians consider those results along with other valuable risk factors,

such as obesity, dietary causes of hypertriglycedemia.

In this respect, PT10V Diabetes 4V provides four tests of glucose (GLU), fructosamine (FRUC),

total cholesterol (CHOL), and triglyceride (TRIG).

• GLU: A circulating blood glucose concentration.

• FRUC: A stable complex of blood glucose and proteins produced by an irreversible

glycosylation of proteins. A fructosamine level assesses the average blood glucose

concentration over the previous 1-2 weeks.

• CHOL: A part of all lipoproteins as an indicator of abnormal lipid disorder.

• TRIG: A compound of a glycerol and fatty acids as a vital energy source for cell and an

indicator of abnormal lipid metabolism

What are the benefits of PT10V Diabetes 4V testing?PT10V Diabetes 4V with fructosamine gives a simpler, more reliable way to manage the

increasing diabetic cases in your practices;

√ Diagnosis and monitoring of diabetes mellitus

(Glucose, Fructosamine)

√ Ruling out stress-induced hyperglycemia

(Fructosamine)

√ Monitoring diabetic patients in conjuction with insulin therapy

(Glucose, Fructosamine)

√ Monitoring patient’s diet to address obesity and weight control

(Glucose, Chelesterol, Triglyceride)

FRUC measurement as well as GLU is highly recommended at all monitoring steps in 2018 AAHA Diabetes Management Guideline;

• Monitoring on the initial day of

treatment

• Monitoring until control is attained

• Ongoing monitoring

Diabetic dogs and cats can

sustain good quality of life

with proper diagnosis and

PT10V Diabetes 4V.

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CASE STUDY : D

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USBMemory

WIFI USB Dongle

Barcode Scanner

LAN Connectivity

8.1 in(205 mm)

5.5 in(140 mm)

8.1 in(206 mm)

The lightweight and compact design (140 x 205 x 206 mm footprint, 2 kg weight) of PT10V improves the efficient use of work space. Despite its size, the analyzer includes a 4.3 inch touch panel and a built in thermal printer.

PT10V is compatible with multiple external devices. (WIFI USB dongle, USB memory, barcode scanner, and LAN connectivity)

Compact design

Support for multiple devices

Compact

AccessibleConnects easily with your PMS (Practice Management System) to streamline workflow.The results can be viewed through multiple devices such as PC, mobile phone and other mobile devices for efficient database management.

PC Application

Mobile Application

Tablet Application

PMS

Easy to use

PT10V provides fast diagnosis with testresults in about 10 minutes* and

improves patient satisfactionby reducing waiting time.

Rapid results

Optimized combination of up to 16 test parameters enables fast and accurate diagnosis (including calculated values).

Multi-parameter testing

* Position of the analytes may be subject to change without notification.

*Elapsed time may vary depending on test environment.

A small amount of 70 μl of blood (plasma, serum) can be used for various tests and enhance the user convenience.

User friendly interface with intuitive icons on the wide touch screen allow users to easily operate

the system and enhance user experience.

Minimal blood sampling

Intuitive User Interface

PT10V Comprehensive 16V