prostate: hormone- sensitive (including...

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Prostate: Hormone- sensitive (including localized) Oral presentations Dott. Luca Galli U.O. Oncologia Medica 2 Universitaria Azienda Ospedaliero-Universitaria Pisana Pisa

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Page 1: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Prostate: Hormone-sensitive (including

localized) Oral presentations

Dott. Luca Galli

U.O. Oncologia Medica 2 Universitaria

Azienda Ospedaliero-Universitaria Pisana

Pisa

Page 2: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone
Page 3: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Elegibility

Page 4: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Study schema

Page 5: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Objectives

Page 6: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Patient Baseline Characteristics

Page 7: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Summary of Adverse Events

Page 8: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Leukemia Summary slide

Page 9: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Cause of Death

Page 10: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

ITT Disease Free Survival

Page 11: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Overall Survival

>80% vivi a 10 anni

Page 12: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Conclusions

Page 13: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone
Page 14: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Background

Page 15: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Purpose Moving forward…

To evaluate whether the Decipher genomic classifier determined

from biopsy specimens is prognostic for mets and PCSM in a mixed cohort treated with RP

and RT ± ADT

Page 16: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Patients

Page 17: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

High 20%

Int Low

Page 18: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

Page 19: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

Page 20: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

Page 21: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

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Future perspectives

Page 23: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Conclusions

Too few low risk pts for use in the decision between surveillance vs treatment

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Background and hypotheses

Page 26: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Methods

Page 27: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

NO HER-2 subtype!

Page 28: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

Page 29: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Results

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What’s behind all this?

Page 31: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Clinical implications?

**ADT given either adjuvant or early salvage post prostatectomy

* *

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Can PAM50 give us something more?

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Can PAM50 give us something more?

Page 34: Prostate: Hormone- sensitive (including localized)media.aiom.it/userfiles/files/doc/AIOM-Servizi/slide/20170303MI_13... · Adjuvant androgen deprivation (ADT) versus mitoxantrone

Future perspectives

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Conclusions