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2 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Table of Contents
Words of Welcome 3
Committees 4
Practical Information 5
Contact Us 10
Scientific Program Associated Meetings (by invitation only) 11
Program at a Glance 12
ECS Workshops 15
Detailed Program 17
Awards 30
Social Events 32
Posters 35
Industry Sponsored Symposia 48
Our Sponsors/Exhibitors 49
Partners 56
Notes 57
Exhibitor Floor plan and Legend 58
Thank You to our Sponsors/ Exhibitors and Partners 60
3ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Words of WelcomeWe are happy and proud to welcome you to the third European Microcirculation and Vascular Biology conference in Maastricht. Already being the third joint conference of ESM and EVBO, this promises to be a unique, successful, and inspiring series of meetings in the (cardio)vascular field.
Improving vascular health is an important goal to pursue, as cardiovascular diseases account for almost half of all deaths in Europe. Disturbances in normal (micro)vascular biology are at the basis of many diseases. From classical cardiovascular diseases, like myocardial infarction and stroke, to cardio-metabolic diseases, like diabetes and hypertension with related complications such as dementia, cognitive decline, heart failure, and chronic kidney disease. Of course, cancer and post-surgical tissue regeneration and wound healing clearly have an important vascular component. This broad range of diseases undoubtedly underlines the need to expand our knowledge on the basic mechanisms underlying the disturbances in normal (micro)vascular biology. With this conference we aim to address many aspects of these mechanisms through state-of-the-art symposia and workshops.
One of our aims is to stimulate and educate early career scientists (ECS). Besides a Young Investigator Symposium and many travel and poster awards, we composed a special program for our young delegates, including many workshops, their own social program, and preferred accommodation to stimulate new networks.
Maastricht is known for its 1992 Treaty to further European integration and the creation of one European currency, the euro. But Maastricht is also known as one of the oldest and certainly most beautiful cities of the Netherlands. It is positioned close to Belgium and Germany, and over 50% of the University’s students are foreign, giving the city an international style. This, together with the warm and hospitable atmosphere of Maastricht will ensure an exciting and fruitful stay.
On behalf of the national organizers: Jaap van Buul, Ed Eringa, Stephan Huveneers, and Guido Krenning.
Judith Sluimer Boy Houben Meeting chair Meeting Chair
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CommitteesLocal Organizing Committee
Dr. Judith Sluimer (CARIM/MUMC+, Maastricht)Dr. Boy Houben (CARIM/MUMC+, Maastricht)Margaux Fontaine (CARIM/MUMC+, Maastricht)Tate Chimhanda (CARIM/MUMC+, Maastricht) Dutch Organizing Committee
Dr. Judith Sluimer (CARIM/MUMC+, Maastricht)Dr. Boy Houben (CARIM/MUMC+, Maastricht)Prof. Dr. Jaap van Buul (Sanquin, Amsterdam)Dr. Ed Eringa (VUMC, Amsterdam)Dr. Stephan Huveneers (AMC, Amsterdam)Dr. Guido Krenning (UMCG, Groningen) Young Investigator Symposium
Prof. Dr. Y. Alexander (United Kingdom)Dr. R. Boon (the Netherlands)Prof. Dr. M. Graupera (Spain) Core Scientific Committee
Prof. Dr. A. Koller (Hungary)Prof. Dr. Y. Alexander (United Kingdom)Prof. Dr. H. Morawietz (Germany)Dr. B. Bussolati (Italy)Dr. B. Houben (the Netherlands)Dr. J. Sluimer (the Netherlands)
International Scientific Committee
Prof. Dr. Y. Alexander (United Kingdom)Prof. Dr. A. Baker (United Kingdom)Prof. Dr. E. van Bavel (the Netherlands)Dr. R. Benedito (Spain)Prof. Dr. C. Betsholz (Sweden)Prof. Dr. N. Brown (United Kingdom)Dr. B. Bussolati (Italy)Prof. Dr. J.Y. Han (China)Prof. Dr. P. Hordijk (the Netherlands)
Prof. Dr. B. Imhof (Switzerland)Prof. Dr. F. Kiefer (Germany)Prof. Dr. A. Koller (Hungary)Prof. Dr. H. Morawietz (Germany)Dr. G. Pages (France)Prof. Dr. J. Pearson (United Kingdom)Prof. Dr. R. Siow (United Kingdom)Prof. Dr. C. Stehouwer (the Netherlands)Prof. Dr. D. Vestweber (Germany)
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Practical InformationVenue
The conference will take place in the Maastricht Exhibition & Congress Centre (MECC) in Maastricht (address: Forum 100). The congress centre consists of three multi-functional floors which can all be reached from the registration area. All meetings, plenary and parallel sessions are organized in the congress centre. Some early career scientist workshops and Monday morning sessions are organized in Maastricht University (entrance: Universiteitssingel 40, 5min from MECC).
Accessibility
Please come to the conference help desk, located in the entrance, Level 1 / Trajectum of MECC conference centre, if you need any information or support. Meeting rooms are located on Level 0 / Lobby and Level 2 / Promenade. (Please be aware of different Conference Secretariat opening hours).
Language
The official language of the conference is English.
Accommodation
Please come to the registration desk for any hotel booking changes.
Download Google maps for off-line use to orient yourself with GPS
Venues:• MECC Conference Centre Maastricht : Forum 100, 6229 GV Maastricht• Maastricht University Medical Centre : P. Debyelaan 25, 6229 HX, Maastricht
Social Events:• Welcome Reception Town Hall : Markt 78, 6211 CL Maastricht• Conference Party : Rebelle Maastricht, Kesselskade 43, 6211 EN Maastricht• Early Career Scientist BBQ and Party : Stayokay Hostel, Maasboulevard 101,
6211 JW Maastricht
Coffee Bar Nearby:• Bakery Cafe : Joseph Bechlaan 100, 6229 GR Maastricht• University Sports Centre Caffee/Lunch Bar RIVAZZA, P. Debyeplein 15,
6229 HA Maastricht
Hotels Nearby:• Hotel Apart Randwijk : Endepolsdomein 30, 6229 EM Maastricht• Hotel NH Maastricht : Forum 110, 6229 GV Maastricht
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Banking Facilities
An ATM machine is located at the main entrance / Level 1 of MECC Maastricht.
Certificate of Attendance
Participants who are entitled to receive a Certificate of Attendance will receive an email from the Registration Department after the conference.
CME Accreditation
ESM-EVBO 2019 has been granted 16 European CME credits (ECMEC®s), which equates to a maximum of 16 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spends in the educational activity.
Delegates who would like to collect CME credits should make sure their badge is scanned before entering a session room to determine the number of hours to be credited. Please approach the staff member at the entrance to each session room to have your badge scanned. You will also be asked to complete a feedback form and a certificate will be provided after the conference when your attendance has been confirmed.
Cloakroom
There is a guarded cloakroom on arrival on Monday and departure on Thursday on Level 1.
There is no guarded cloakroom on Tuesday and Wednesday. There are coat racks on Level 1 / Entrance Level.
Coffee and Lunch Breaks and Poster Session Nutrition
Catering during breaks is served in the exhibition area on Level 0 and Level 1. The exhibition is located on Level 0 and Level 1. Lunch Boxes are available on Tuesday and Wednesday. A special catering station for delegates with dietary requirements is available on Level 0.
Lunch Options on Monday and Thursday:
There is a restaurant in the MECC Centre located on Level 0 (just around the corner from the Conference Help Desk) and the Hotel NH next to the MECC has an a-la-carte restaurant on the ground floor.
There are two coffee bars in 5 min walking distance. Bakery Cafe (Joseph Bechlaan 100) and RIVAZZA Caffee/Lunch Bar in the UM Sports Building (P. Debyeplein 15).
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Conference Badges
All participants, accompanying persons and exhibitors must wear the identification badges. Entrance to meeting halls, Exhibition area, catering stations and to all social events will not be permitted to any person without a badge.
Conference Mobile App
Please use the download link provided in your information email “ESM-EVBO 2019 useful information for your travel to Maastricht” to download the Conference Mobile App.
Conference Programme
The detailed conference programme is available online (www.esm-evbo2019.org) and also via the ESM-EVOB 2019 Mobile App.
Opening Hours Conference Registration Help Desk*Monday 15 April , 2019 11:00 – 16:30 10:00 – 18:00Tuesday 16 April, 2019 10:30 – 13:00 and 15:30 – 18:00 07:30 – 20:00Wednesday 17 April, 2019 10:30 – 13:00 and 15:30 – 18:00 07:30 – 19:00Thursday 18 April, 2019 10:00 – 11:00 08:00 – 13:00
*See page 8 for information about the Help Desk.
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Help Desk The Help Desk is able to help you for general information. During Conference Secretariat opening hours, you are able to register on-site, change your badge, pay an outstanding registration amount, change your hotel and buy Conference Party or Student Party tickets.
City Map Maastricht
You will find your city map in your conference bag.
Exhibition Exhibition opening hours
The exhibition is located on Level 1 (Lobby) Monday, 15 April 13:00 – 17:30and Level 1 (Entrance/ Trajectum) next to Tuesday, 16 April 09:30 – 19:00the Poster boards and catering stations Wednesday, 17 April 09:30 – 19:00for coffee breaks and lunch boxes. Thursday, 18 April 09:30 – 12:00
First Aid
For any emergencies please note the Maastricht Hospital is located just across from the MECC Conference Centre. Please visit the conference help desk for assistance. National emergency phone number is 112.
Information Desk Please come to the conference help desk. City information and restaurant guides are available.
Liability and Insurance The organizers cannot accept liability for personal accidents or loss of or damage to private property of participants. Participants are advised to take out their own personal travel and health insurance for their trip.
Lost and Found The conference help desk will collect all lost and found objects.
Parking MECC Maastricht has several different car parking areas which are within walking distance of the entrance. Parking at MECC Maastricht is free for the first half hour. After 30 minutes you pay € 3 per full hour, with a maximum of € 15 per 24 hours.
Posters Posters can be found on Level 0 and Level 1. Posters are mounted for 1 1/2 days. Posters change Tuesday evening after 18:30. Please check the poster plan in the pocket programme to find the location and day of your poster(s).
Poster presenters: please check poster guidelines for instructions. For questions and poster mounting material please contact the conference help desk. Poster sessions are Tuesday and Wednesday from 17:00 – 18:30.
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Registration Please come to the Conference Help Desk, located on Level 1/ / Entrance of the MECC Conference Centre for your pre-registered badge pick-up and on-site registration, as well as if you need any information or support. Please note different opening hours for the Conference Secretariat/Registration Services.
Your Registration includes :• Access to the conference centre and scientific sessions• Pocket program and conference bag• Welcome Reception (if registered)• Coffee Breaks• Poster Session Nutrition• 2 Lunch Boxes (not included with on-site registration)
Smoking Policy This will be a non-smoking event. Smoking is prohibited in all buildings and in all restaurants in Maastricht, providing limited designated smoking areas.
Safety and Security It is advisable that you do not leave bags or suitcases unattended at any time, whether inside or outside the session halls.
Social Events Several public buses (every 10 min.) and the train (4 times per hour) run to Maastricht central railway station or Markt (see details on page 33). The train also takes you from Maastricht Randwijck to Central. Download NS planner app for details.
Welcome Reception : Monday 15th April; 18:00 – 19:00 Town Hall Address: Maastricht Town Hall, Markt 78, 6211 CL Maastricht
Early Career Scientist BBQ and Party : Tuesday 16th April; start 19:00 open-ended Address: Stayokay Hotel, Maasboulevard 101, 6211 JW Maastricht
Conference Party Rebelle Maastricht : Wednesday 17th April ; start 19:30 open-ended Address: Rebelle Maastricht, Kesselskade 43, 6211 EN Maastricht Social Media Facebook - ESMEVBO 2019 Twitter -https://twitter.com/ESMEVBO2019/ @ESMEVBO2019/ # ESMEVBO2019
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Speaker Centre The Speaker Centre is located on Level 1 / Entrance Level behind the posters.
All presenters must check in at the Speaker Centre after their arrival and hand in their presentation at least 3 hrs before their scheduled session.
Speaker Centre Opening Hours :
Monday 15 April , 2019 10:00 – 17:00
Tuesday 16 April, 2019 07:30 – 17:00
Wednesday 17 April, 2019 07:30 – 17:00
Thursday 18 April, 2019 07:30 – 11:00
Wi-Fi
The MECC wi-fi is available free of charge for delegates in the conference centre. Network : MECC Free WiFi (no Username and no Password required, you only have to accept the terms and conditions). Please note : idle time is 60 minutes (which means you need to login again after 60 min). *Please bear with us if you have trouble connecting to the wifi, as this may be due to the volume of people and number of devices being used at the same time.
Toilets Main toilets are located on Level 0
Contact UsA111 Power of Conference Service is a Canada and Switzerland based professional conference organiser. Please contact us for any questions regarding the conference, registration, sponsorship, as well as for hotel reservations and hotel changes.
ESM-EVBO 2019 Registration <[email protected]>Tel + 31-6-47002024 Within The Netherlands dial 06-47002024
A111 Power of Conference ServiceKäsereistrasse 3, 4206 Seewen-Basel, Switzerland300-422 Richards Street, Vancouver BC, V6B 2Z4, CanadaEmail: [email protected]
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Contact Us
Scientific Program Associated Meetings (by invitation only)Monday 15 April 2019 10:00 – 11:30 Room : 0.4/0.5 Brussels/ParisBoard Meeting ESM European Society for Microcirculation
10:00 – 11:30 Room : Office 1.3Board Meeting EVBOEuropean Vascular Biology Organization
Tuesday 16 April 2019
18:30 – 19:30 Room : 2.1 ColoradoGeneral Assembly ESM European Society for Microcirculation
18:30 – 19:30 Room : 0.4/0.5 Brussels/ParisGeneral Assembly EVBOEuropean Vascular Biology Organization
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Program at a Glance
Day 1 – Monday April 15
MUMC
9:00-12:00 ECS Workshops
MECC10:00-11:30 Board meeting ESM
10:00-11:30 Board meeting EVBO
Registration opens 10:00
Arrival+registration
12:30 – 13:15
Welcome and openingJudith Sluimer
Boy HoubenRianne Letschert
13:15 – 14:00
Session 1.1
EVBO Medal lectureElisabetta Dejana
14:00 – 15:45Session 1.2
Young Investigator session
15:45 – 16:15 Coffee break / Exhibition
16:15 – 17:00
Session 1.3
Coen Stehouwer Microvascular function and cardiometabolic diseases
17:00 – 18:00 Make your way to City Hall
18:00 – 19:00 Welcome reception City Hall
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Day 2 – Tuesday April 16
MECC7:45– 8:25 Different Morning ECS workshops
8:30 – 9:10
Session 2.1
DHF lecture: Dietmar VestweberRegulation of endothelial junctions during leukocyte extravasation
09:15 – 10:30
Session 2.2 Session 2.3 Session 2.4
Lymphatic vessels in development and disease
Cerebral circulation, from arterioles to arteries from
animals to human
Intra-arterial treatment in Acute Ischemic Stroke:
how to clean up the microcirculation?
10:30 – 11:00 Coffee break / Exhibition
11:00 – 12:30
Session 2.5 Session 2.6 Session 2.7
Endothelial cell adhesion Vascular ageing and senescence
The ‘other’ cerebral circulation: paravascular channels and lymphatics
(DHF lecture)
12:30 – 13:-00 Lunch break / Exhibition
13:00 – 14:00
Lunch Session 2A Lunch Session 2B
Sponsored industry symposia Microvascular High-tech
solutions from bench to bed Physical vascular therapy
Pathomechanisms microcirculation in CVD
12:45 – 13:30ECS workshop
14:15 – 15:45
Session 2.8 Session 2.9 Session 2.10
Angiogenesis in regeneration and disease
ESC WG symposium: EC dysfunction
CVR symposium: Non-coding RNA in pathological
vascular remodelling
15:45 – 16:15 Coffee break / Exhibition
Session 2.11
16:15 – 17:00 Christoph Scheiermann: Circadian rhythms in leukocyte-endothelial cell interactions
17:00 – 18:30 Poster sessions. Exhibition and drinks
18:30 – 19:30 General assemblies ESM members
18:30 – 19:30 General assemblies EVBO members
19:00 – 22:00 Student party
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Day 3 – Wednesday April 17
MECC8:00 – 8:40 Different Morning workshops ECS
8:00 - 8:45Session 3.0
Launch of the ESM working group on Retinal Microvascular Research
8:45 – 9:25
Session 3.1
Christer Betsholtz Vascular heterogeneity
09:30 – 10:30
Session 3.2 Session 3.3
Vascular cell heterogeneity CVR-session: Oxidative stress and Infl ammation
10:30 – 11:00 Coffee break / Exhibition
11:00 – 12:30
Session 3.4 Session 3.5
Vascular cell plasticity and clonality Clinical microvascular dysfunction in cardiometabolic diseases
12:30 – 13:-00 Lunch break / Exhibition
13:00 – 14:00Lunch Session 3A 13:00 – 14:00 Lunch Session 3B 13:00 – 13:30
Sponsored Industry SymposiaRetinal Vessel Analysis
Sponsored Industry SymposiaDeoxyhemoglobin Vasodilator
14:15 – 15:45
Session 3.6 Session 3.7
Vascular Pathophysiology, diagnostics, and treatment Resistance arteries
15:45 – 16:15 Coffee break / Exhibition
16:15 – 17:00Session 3.8
Dave Newby Clinical imaging of vascular disease
17:00 – 18:30 Poster sessions, exhibition and drinks
18:30 – 19:30 Make your way to the Conference Party
19:30 – open ended Conference party
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Day 4 – Thursday April 18
8:30 – 9:10
Session 4.1
EVBO lecture: Rui Miguel Benedito
Using multispectral genetic mosaics to enlighten endothelia heterogeneity during angiogenesis
09:30 – 10:30
Session 4.2 Session 4.3
Endothelial metabolism and mitochondrial function in angiogenesis Vascular drug targeting
10:30 – 11:00 Coffee break / Exhibition
Session 4.4
11:00 – 11:45 ESM Malpighi Award Lecture: Akos Koller: Going with the fl ow in microcirculation
11:45 – 12:15 JVR / ESM Award lecture: Lydia Sorokin: The role of endothelial laminins in vascular function
12:15 – 12:30 Travel and Poster Awards and closing
12:30 Departure
ECS Workshops Monday, April 15, 2019 Plenary Sessions 09:00 – 12:30 Early Career Scientists Workshops
Maastricht University or MECC ECS Workshops I / Pre-registration required
10:30 – 12:00 Mass spectometry imaging Meet 10:20 Maastricht University, Universiteitssingel 50, room 5.467 Host: Benjamin Balluff, Maastricht, Netherlands
9:00 – 12:00 Non-invasive imaging Meet 8:50 Maastricht University hospital, P. debyelaan 25, Greepzaal level 4 Host: Eline Kooi. Maastricht, Netherlands 9:00 – 12:00 Press communication and Maximize impact from your research Meet 9:50 Maastricht University, Oxfordlaan 70, ground floor meeting room Host: Henri Theunissen, Maastricht, Netherlands and Nieky van Steenkiste, Maastricht, Netherlands
(Early Career Scientists)
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Tuesday, April 16, 2019 7:45 – 8:25 Early Career Scientists Workshops II
Pre-registration required
7:45 – 8:25 0.2/0.3 Copenhagen /Berlin (MECC) Meet 07:40 Meet the professor
Andrew Baker, Edinburgh University, United Kingdom
7:45 – 8:25 2.1 Colorado (MECC) Meet 07:40 Meet the professor Jaap van Buul. Sanquin Amsterdam, The Netherlands
7:45 – 8:25 1.3 office (MECC) Meet 07:40 Meet the professor
Yvonne Alexander, Manchester Metropolitan University, United Kingdom
7:45 – 8:25 1.2 office (MECC) Meet 07:40 Meet the professor
Mariona Graupera. IBIDELL, Barcelona, Spain
12:45 – 13:30 Early Career Scientists Workshop II Lunch S.2C Pre-registration required 0.2/0.3 Copenhagen /Berlin (MECC) Cardiovascular pathophysiology of old
age hypertension: the virtual patient speaks (bring your own laptop, pre-installed CircAdapt tool). Koen Reesink, Maastricht University, The Netherlands
Wednesday, April 17, 20197:45 – 8:25 MECC – Early Career Scientists Workshop III
Pre-registration required
7:45 – 8:25 1.3 office (MECC) Meet the professor Rafael Kramann, RWTH Aachen University, Germany 7:45 – 8:25 1.2 office (MECC) Meet the professor Rhian Touyz, University of Glasgow, United Kingdom 12:45 – 14:00 Maastricht University – Early Career Scientists Workshop III Pre-registration required Maastricht University hospital, Verheylaan 5.m1.031 Talk to the editor of cardiovascular research Tom Guzik, Glasgow University, United Kingdom
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Detailed Program Monday, April 15, 2019
Monday, A
pril 15, 201912:30 – 13:15 PLENARY ROOM 0.4/0.5 Brussels/Paris – Session 1.0. – Welcome and opening
12:30 – 12:45 S.1.0.1 Welcome and opening words Boy Houben, Maastricht University, The Netherlands Judith Sluimer, Maastricht University, The Netherlands 12:50 – 13:05 S.1.0.3 Official Opening of the Conference: Towards a more balanced system of
rewarding academics Rianne Letschert, Rector of Maastricht University, The Netherlands
13:15 – 14:00 PLENARY ROOM 0.4/0.5 Brussels/Paris – Session 1.1. – EVBO Medal lecture Yvonne Alexander, Manchester Metropolitan University, United Kingdom (chair) Benedetta Bussolati, University of Turin, Italy (chair) 13:15 – 14:00 Transcriptional regulation of the Blood Brain Barrier Elisabetta Dejana, University of Milan, Italy 14:00 – 15:45 PLENARY SPEAKERS 0.4/0.5 Brussels/Paris Session 1.2. Young Investigator session Yvonne Alexander, Manchester Metropolitan University, United Kingdom (chair)
Mariona Graupera, Institut d’Investigació Biomèdica de Bellvitage, Spain (chair) 14:05 – 14:25 S.1.2.1 Metabolic interactions between the endothelium and the muscle
microenvironment Katrien de Bock, ETH, Zürich, Switzerland 14:25 – 14:45 S.1.2.2 Telomerase as therapeutic agent for cardio protection Christian Bär, Hannover Medical School, Germany 14:45 – 15:05 S.1.2.3 Angiocrine signals in ageing and disease Anjali Kusumbe, University of Oxford, United Kingdom 15:05 – 15:25 S.1.2.4 Dissecting the roles of altered cell type composition and cell specific
responses to proatherogenic stimuli in contributing to global gene expression changes in atherosclerotic aorta Minna Kaikkonen-Määttä, University of Eastern Finland, Finland
15:25 – 15:45 S.1.2.5 Endothelial Cell Orienteering Claudio Franco, Universidade de Lisboa, Portugal 15:45 – 16:15 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 16:15 – 17:00 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 1.3.
Microvascular function and cardiometabolic diseases Boy Houben, Maastricht University, The Netherlands (chair)
Ed Eringa, Free University Amsterdam, The Netherlands (chair) 16:15 – 17:00 Microvascular function and cardiometabolic diseases
Keynote: Coen Stehouwer, Maastricht University, The Netherlands 18:00 – 19:00 Welcome Reception City Hall Maastricht
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9:15 – 10:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 2.2 Lymphatic vessels in development and disease Ferdinand Le Noble, Karlsruhe Institue of Technology KIT, Germany (chair) Lena Claesson-Welsh, Uppsala University, Sweden (chair)
9:15 – 9:50 S.2.2.1 Vascular bed-specific mechanisms of lymphatic development and disease Taija Makinen, Uppsala University, Sweden
9:50 – 10:05 S.2.2.2 Uparap/endo180 receptor, a gatekeeper of lymphatic branching and
organization during pathological lymphangiogenesis Florent Morfoisse, University of Liege, Belgium 10:05 – 10:20 S.2.2.3 Regulation of Cardiac Lymphatic Development by Tbx1
Elizabeth Illingworth, University of Salerno, Italy 10:20 – 10:35 S.2.2.4 Bradykinin Signaling Regulates Solutes Permeability and Cellular
Junctions Organization in Lymphatic Endothelial Cells Sybille Kempe, Unikersitätsklinik Ulm, Germany
9:15 – 10:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 2.3 Cerebral circulation, from arterioles to arteries from animals to
human Akos Koller, University of Physical Education, Budapest, Hungary (chair) Peter Toth, University of Pecs, Hungary (chair)
9:15 – 9:35 S.2.3.1 Role of synergism between pressure and flow activated cerebrovascular mechanisms and mechanotransduction signaling in the autoregulation of cerebral blood flow Akos Koller, University Of Physical Education, Hungary
9:35 – 9:55 S.2.3.2 Integrated Assessment of Cerebral Blood Flow Regulation in Humans:
Dynamic Cerebral Autoregulation, CO2 Reactivity and Neurovascular Coupling Ronney Panerai, University Of Leicester, United Kingdom
9:55 – 10:15 S.2.3.3 Traumatic brain injury-induced cerebrovascular alterations
Peter Toth, University Of Pecs, Hungary 10:15 – 10:35 S.2.3.4 The effects of Vaccinium Myrtillus Extract on Hamster Pial
Microcirculation during Hypoperfusion-Reperfusion Injury Antonio Colantuoni, Federico II University Medical School-Naples, Italy
Tuesday, April 16, 2019 8:30 – 9:10 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 2.1
Dutch Heart Foundation lecture Jaap van Buul, Sanquin and University of Amsterdam, The Netherlands (chair) Stephan Huveneers, University of Amsterdam, The Netherlands (chair)
8:30 – 9:10 Regulation of endothelial junctions during leukocyte extravasation Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Münster, Germany
9:10 – 9:15 Break
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9:15 – 10:30 CONCURRENT SESSION ROOM 0.2/0.3 Copenhagen /Berlin Session 2.4 Intra-arterial treatment in Acute Ischemic Stroke: how to clean up the
microcirculation? Ed van Bavel, University of Amsterdam, The Netherlands (chair) Stephen Payne University of Oxford, UK (chair)
9:15 – 9:35 S.2.4.1 Microvascular events in acute ischemic stroke Ed van Bavel, University of Amsterdam, The Netherlands 9:35 – 9:55 S.2.4.2 Coupled multi-scale models of the microcirculation in the cerebral cortex Stephen Payne, University of Oxford, United Kingdom 9:55 – 10:15 S.2.4.3 the VWF/ADAMTS13 axis in cerebral ischemia/reperfusion injury Simon de Meyer, KU Leuven, Belgium 10:15 – 10:30 S.2.4.4 Unravelling the (sub)cellular mechanisms of low frequency
electromagnetic stimulation as ischemic stroke therapy Hannelore Kemps, Hasselt University, Belgium
10:30 – 11:00 Coffee Break and Exhibition (Exhibition Area Level 0 and 1)
11:00 – 12:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 2.5 Endothelial cell adhesion Stephan Huveneers, University of Amsterdam, The Netherlands (chair) Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Münster, Germany (chair)
11:00 – 11:30 S.2.5.1 Leukocyte transendothelial migration: the endothelium in control Jaap van Buul, Sanquin and University of Amsterdam, The Netherlands
11:30 – 11:45 S.2.5.2 ROCKs play a major role in the control of gene expression program by the CCM
complex Daphné Vannier, Institute For Advanced Biosciences Cnrs/inserm, France 11:45 – 12:00 S.2.5.3 High-level Nrf2 Activation Promotes Endothelial Detachment– Implications for
Acute Coronary Syndromes Triggered by Endothelial Erosion of Plaques Alex Langford-Smith, Manchester Metropolitan University, United Kingdom 12:00 – 12:15 S.2.5.4 Mitochondrial metabolism limits ECM formation in human iPSC-derived
endothelium Gesa Tiemeier, Leiden UMC, The Netherlands 12:15 – 12:30 S.2.5.5 Bosutinib Protects against Vascular Leakage by Improving Endothelial Cell-
Matrix Adhesion Liza Botros, University of Amsterdam, The Netherlands
Tuesday, A
pril 16, 2019
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11:00 – 12:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 2.6 Vascular ageing and senescence Guido Krenning, University of Groningen, The Netherlands (chair) Guido de Meyer, University of Antwerp, Belgium (chair)
11:00 – 11:30 S.2.6.1 Vascular cell ageing and senescence Martin Bennett, University of Cambridge, United Kingdom 11:30 – 11:45 S.2.6.2 Aging downregulates lamin A/C expression in smooth muscle cells: A
potential mechanism contributing to age-dependent cardiac disease Alberto Del Monte Monge, Centro Nacional De Investigaciones Cardiovasculares,
Spain 11:45 – 12:00 S.2.6.3 Resistance Vasculature in Chronic Kidney Disease: focus on function,
structure and senescence signature Samsul Arefin, Karolinska Institutet, Sweden
12:00 – 12:15 S.2.6.4 Translational approaches to understanding aging-induced
cerebromicrovascular dysfunction Andriy Yabluchanskiy, University Of Oklahoma Health Sciences Center, USA 12:15 – 12:30 S.2.6.5 Keap-1-dependent interplay between S-nitrosylation and protein
aggregation in ageing endothelium Aleksandra Kopacz, Jagiellonian University, Poland
11:00 – 12:30 CONCURRENT SESSION ROOM 0.2/0.3 Copenhagen /Berlin Session 2.7 The ‘other’ cerebral circulation: paravascular channels and
lymphatics Erik Bakker University of Amsterdam, The Netherlands (chair) Steven Proulx ETH, Zürich, Switzerland (chair)
11:00 – 11:20 S.2.7.1 Dutch Heart Foundation lecture: Manipulating Meningeal lymphatic vessels in Development and Disease
Salli Antila, University of Helsinki, Finland 11:20 – 11:40 S.2.7.2 In vivo imaging of the outflow of cerebrospinal fluid through lymphatic
vessels in mice Steven Proulx, ETH, Zürich, Switzerland 11:40 – 12:00 S.2.7.3 Fluid flow in the brain, role of paravascular spaces and hypertension Erik Bakker, University of Amsterdam, The Netherlands 12:00 – 12:15 S.2.7.4 Re-evaluation of CSF outflow in mice using non-invasive MRI dynamic
contrast-enhanced imaging Yann Decker, University Of The Saarland, Germany 12:15 – 12:30 S.2.7.5 Lymph Flow Mediated Postnatal Remodeling of Meningeal Lymphatics is
Required for the Uptake and Transport of Macromolecules from the Central Laszlo Balint, Semmelweis University Budapest, Hungary 12:30 – 13:00 Lunch Break and Exhibition (Exhibition Area Level 0 and 1)
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13:00 – 14:00 PLENARY ROOM 0.4/0.5 Brussels/Paris Details see page 48 Lunch S.2A Industry Sponsored Lunch Symposia: Microvascular High-tech
solutions from bench to bed Physical vascular therapy Ralph Burger, Bemer Int. AG, Germany (chair)
Joshua Berka, Infinity Health Source, USA (chair)
13:00 – 13:15 Lunch S.2A.1 Fluorescence imaging procedure for lymphatic surgery Christian Taeger, University Hospital of Regensburg, Germany 13:15 – 13:30 Lunch S.2A.2 Physical vascular therapy affects heart rate and heart rate
asymmetry in patients with coronary heart disease Laszlo Hejjel, University of Pecs, Hungary
13:30 – 13:45 Lunch S.2A.3 Observations and experiences in the application of a therapy
blanket by induction of electromagnetic force on the tissue of horses Hermann Josef Genn, Horse Clinic Mühlen, Germany
13:45 – 14:00 Lunch S.2A.4 Physical Vascular Therapy: Clinical Interventions and
Preventative Medicine Joshua Berka, Infinity Health Source, USA 13:00 – 14:00 2.1 Colorado Lunch S.2B Pathomechanisms microcirculation in CVD Akos Koller, University of Physical Education, Budapest, Hungary (chair) Ines DrenjanČević, University of Osijek, Croatia (chair)
13:00 – 13:15 Lunch S.2B.1 Vascular Cognitive Impairment in experimental hypertension: the microglial culprit Danielle Kerkhofs, Maastricht University, The Netherlands
13:15 – 13:30 Lunch S.2B.2 Increased oxidative stress underlies impaired endothelial
function and vascular reactivity with high salt dietary intake, independently of blood pressure changes – translational studies
Ines DrenjanČević, University of Osijek, Croatia 13:30 – 13:45 Lunch S.2B.3 Treatment with a NAD+ Booster Rescues Cerebromicrovascular
Function in Aged Mice Zoltan Ungvari, University of Oklahoma HSC, USA 13:45 – 14:00 Lunch S.2B.4 Aprotinin preserves cremaster microcirculatory perfusion, but not
renal perfusion following cardiopulmonary bypass in rats Nicole A.M. Dekker, Free University of Amsterdam, The Netherlands 14:00 – 14:15 Break to change session rooms
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14:15 – 15:45 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 2.8 Angiogenesis in regeneration and disease Massimo Santoro, University of Padova, Italy (chair) Marjo Donners, Maastricht University, The Netherlands (chair)
14:15 – 14:45 S.2.8.1 Regulation of spinal cord vascularization and regeneration Ferdinand Le Noble, Karlsruhe Institue of Technology KIT, Germany 14:45 – 15:15 S.2.8.2 Imaging hypoxia in living cells Friedemann Kiefer, Max Plank inst. for molecular Biomedicine Münster, Germany 15:15 – 15:30 S.2.8.3 The mitochondrial fission factor Dynamin Related Protein 1 limits VEGF/
VEGFR2 endocytic trafficking and angiogenesis. Stephanie Herkenne, Unipd/uld, Italy
15:30 – 15:45 S.2.8.4 Beyond Pericytes – PDGF-BB Accelerates Vascular Stabilization by
Stimulating the Semaphorin3A/Neuropilin1+ Monocyte Axis Andrea Banfi, Basel University Hospital, Switzerland 14:15 – 15:45 CONCURRENT SESSION ROOM 2.1 Colorado Session 2.9 ESC WG symposium: EC dysfunction Paul Evans, University of Sheffield, United Kingdom (chair) Marie-Luce Bochaton-Piallat, University of Geneva, Switzerland (chair)
14:15 – 14:30 S.2.9.1 Brachial and retinal endothelial dysfunction – methodology and effect of exercise
Arno Schmidt-Trucksäss, University of Basel, Switzerland 14:30 – 14:45 S.2.9.2 Epigenetic changes, oxidative stress and endothelial dysfunction in
diabetes Rosa Suades Soler, Karolinska Institutet, Sweden 14:45 – 15:00 S.2.9.3 Endothelial function and coronary microcirculation Danijela Trifunovic, University of Belgrade, Serbia 15:00 – 15:15 S.2.9.4 Flow-mediated dilation (FMD) and peripheral endothelial function
assessment Michael Shechter, Tel Aviv University, Israel
15:15 – 15:30 S.2.9.5 Metabolic control of vascular function: the role of gastrointestinal
hormones Elena Osto, University Hospital Zurich-institute Of Clinical Chemistry, Zürich,
Switzerland 15:30 – 15:45 S.2.9.6 Endothelial dysfunction in the diabetic patient and the contribution by
circulating endothelial colony forming cells. Yvonne Alexander, Manchester Metropolitan University, United Kingdom
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14:15 – 15:45 CONCURRENT SESSION ROOM 0.2/0.3 Copenhagen /Berlin Session 2.10 CVR symposium: Non-coding RNA in pathological vascular
remodelling Andrew Baker, University of Edinburgh, United Kingdom (chair) Lars Maegdefessel, Karolinska institute, Stockholm, Sweden (chair)
14:15 – 14:35 S.2.10.1 The regulation and function of non-coding RNAs in vascular disease development
Lars Maegdefessel, Karolinska institute, Stockholm, Sweden 14:35 – 14:55 S.2.10.2 Role of non-coding RNAs in atherosclerosis
Jason Johnson, University of Bristol, United Kingdom 14:55 – 15:15 S.2.10.3 Control of endothelial cell function by lncRNAs
Reinier Boon, Free University of Amsterdam, The Netherlands 15:15 – 15:30 S.2.10.4 Functional high-throughput screening identifies a role for microRNA-26b in
the pro-survival of endothelial cells and in vessel calcification. David Mellis, University Of Edinburgh, United Kingdom
15:30 – 15:45 S.2.10.5 Loss of the long non-coding RNA MIR503HG promotes
endothelial-to-mesenchymal transition Alena Shmakova, University Of Edinburgh, United Kingdom 15:45 – 16:15 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 16:15 – 17:00 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 2.11 Leukocyte traffic and vascular interactions Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Münster, Germany (chair) Jaap van Buul, Sanquin and University of Amsterdam, The Netherlands (chair)
16:15 – 17:00 Circadian rhythms in leukocyte-endothelial cell interactions Keynote: Christoph Scheiermann, University Of Geneva, Switzerland
17:00 – 18:30 Poster sessions; exhibition, and drinks (Exhibition Area Level 0 and 1) 18:30 – 19:30 2.1 Colorado – General assembly ESM members 18:30 – 19:30 0.4/0.5 Brussels/Paris – General assembly EVBO members 19:00 – open Student Party – StayOK Hotel
ended
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Wednesday, April 17, 2019 8:00 – 8:45 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 3.0 Launch of ESM working group on Retinal Microvascualr Research Henner Hanssen, Basel, Switzerland (chair) Boy Houben, Maastricht, The Netherlands (chair) 8:00 – 8:10 Introduction and Launch Boy Houben, Maastricht University, The Netherlands
8:10 – 8:25 S 3.0.1 Presentation of the Working Group Henner Hanssen, University Basel, Switzerland 8:25 – 8:35 S 3.0.2 Promisses of angioOCT for retinal microvascular research
Tos Berendschot , Maastricht University, The Netherlands 8:35 – 8:45 S 3.0.3 Developments in Retinal Vessel Analysis
Henner Hanssen, University Basel, Switzerland 8:45 – 9:25 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 3.1 Vascular heterogeneity Rafael Kramann, RWTH Aachen University, Germany (chair) Judith Sluimer, Maastricht University, The Netherlands (chair)
8:45 – 9:25 Cellular interactions and heterogeneity in the blood microvasculature Keynote: Christer Betsholtz, Uppsala University, Sweden 9:25 – 9:30 Break
9:30 – 10:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 3.2 Vascular cell heterogeneity Christer Bestholtz, Uppsala University, Sweden (chair) Jason Kovacic, Icahn School of Medicine, New York, USA (chair)
9:30 – 10:00 S.3.2.1 Heterogeneity of perivascular cells in the kidney Rafael Kramann, RWTH Aachen University, Germany 10:00 – 10:15 S.3.2.2 Single cell sequencing reveals heterogeneity of adventitial mesenchymal
cells in healthy and diseased mice Kim Van Kuijk, Maastricht University, The Netherlands 10:15 – 10:30 S.3.2.3 Single cell transcriptomics identifies a Hedgehog-mediated
immunomodulatory signaling circuit between endothelial and perivascular stromal Ignacio Benedicto, Centro Nacional De Investigaciones Cardiovasculares (cnic), Spain
9:30 – 10:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 3.3 CVR-session: Oxidative stress and Inflammation Henning Morawietz, TU Dresden, Germany (chair) Ingrid Flemming, VRC University of Frankfurt, Germany (chair)
9:30 – 10:00 S.3.3.1 Vascular Redox Regulation: From homeostatic balance to oxidative stress
Ralf Brandes, Goethe-University Frankfurt, Germany
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10:00 – 10:15 S.3.3.2 Induced Pluripotent Stem Cells-derived Cardiomyocytes Improve Heart Function in Murine Model of Myocardial Infarction Józef Dulak, Jagiellonian University, Poland
10:15 – 10:30 S.3.3.3 Partial inhibition of the key glycolytic enzyme PFKFB3 in myeloid cells
impacts whole-body immune cell and liver metabolism, but not atherogenesis Jenny de Bruijn, Maastricht University, The Netherlands
10:30 – 11:00 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 11:00 – 12:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 3.4 Vascular cell plasticity and clonality Guido Krenning, University of Groningen, The Netherlands (chair) Elisabetta Dejena, University of Milan, Italy (chair)
11:00 – 11:30 S.3.4.1 Endothelial to Mesenchymal Transition and Endothelial Cell Plasticity Jason Kovacic, Icahn School of Medicine, New York, USA
11:30 – 12:00 S.3.4.2 Smooth muscle cell plasticity in atherosclerosis. Role of S100A4 Marie-Luce Bochaton-Piallat, University of Geneva, Switzerland 12:00 – 12:15 S.3.4.3 Single cell transcriptome analyses reveal novel targets modulating cardiac
neovascularisation by resident endothelial cells following myocardial infarction Mairi Brittan, University Of Edinburgh, United Kingdom 12:15 – 12:30 S.3.4.4 Towards a molecular atlas of the mouse vasculature Michael Vanlandewijck, Karolinska Institute, Sweden 11:00 – 12:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 3.5 Clinical microvascular dysfunction in cardiometabolic diseases Coen Stehouwer, Maastricht University, The Netherlands (chair) Anton-Jan van Zonneveld, LUMC Leiden, The Netherlands (chair)
11:00 – 11:30 S.3.5.1 Clinical aspects of microvessel dysfunction in cardiometabolic disease Rhian Touyz, University of Glasgow, United Kingdom 11:30 – 11:45 S.3.5.2 Epigenetic regulation of the glomerular endothelial glycocalyx by Enhancer of
Zeste Homolog-2 (EZH2) histone methyltransferase in diabetic nephropathy Marloes Sol, University Medical Center Groningen, The Netherlands 11:45 – 12:00 S.3.5.3 Barcoding in obese: who’s at increased risk for the development of
cardiovascular disease? Margaux Fontaine, Maastricht University, The Netherlands
12:00 – 12:15 S.3.5.4 Markers of Microvascular Dysfunction Are Associated With Incident
Depressive Symptoms: The Maastricht Study Anouk Geraets, Maastricht University, The Netherlands
12:15 – 12:30 S.3.5.5 Effect of L-NMMA on microvascular blood flow and glucose metabolism after
an oral glucose load Alexandra Högstedt, Linköping University, Sweden 12:30 – 13:00 Lunch Break and Exhibition (Exhibition Area Level 0 and 1)
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13:00 – 14:00 PLENARY ROOM 0.4/0.5 Brussels/Paris – Lunch Session See Details Page 48 Lunch S.3A Industry sponsor lunch symposia / Retinal Vessel Analysis Henner Hanssen, University Basel, Switzerland (chair) Doreen Schmidl, University of Austria, Vienna (chair)
13:00 – 13:15 Lunch S.3A.1 Retinal Vessel Analysis: a biomarker of cardiovascular risk Henner Hanssen, University Basel, Switzerland 13:15 – 13:30 Lunch S.3A.2 Retinal microvascular dysfunction in heart disease A. Flammer, University Herzzentrum, Zürich, Switzerland
13:30 – 13:45 Lunch S.3A.3 Retinal vessel imaging: predictor for mortality in end stage renal disease – The ISAR study Christoph Schmaderer, Abteilung Für Nephrologie Klinikum Munich, Germany
13:45 – 14:00 Lunch S.3A.4 Microvascular dysfunction in obesity and diabetes: causes, consequences
and actions Boy Houben, Maastricht University, The Netherlands 13:00 – 13:30 2.1 Colorado See Details Page 48 Lunch S.2B Industry sponsor lunch symposia / deoxyhemoglobin vasodilator
13:00 – 13:15 Lunch S.3B.1 Efficacy of Transdermal CO2 Administration Using the deoxyhemoglobin vasodilator Medical Device to Treat Diabetic Foot Ulcers
Ito Puruhito, Airlangga University Medical Facility, Indonesia 14:00 – 14:15 change session rooms 14:15 – 15:45 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 3.6 Vascular Pathophysiology, diagnostics, and treatment Erik Biessen, Maastricht University, The Netherlands (chair) Margreet de Vries, Leiden UMC, The Netherlands (chair)
14:15 – 14:45 S.3.6.1 Non-coding RNA control of pathological vascular remodelling Andrew Baker, University of Edinburgh, United Kingdom
14:45 – 15:00 S.3.6.2 Adventitial interleukin-6 release is critical for neointima formation
Jochen Dutzmann, University Hospital of Halle, Germany 15:00 – 15:15 S.3.6.3 Dynamic retinal vessel analysis in arterial hypertension: how different parameters
create a whole picture Konstantin Kotliar, Aachen University, Germany
15:15–15:30 S.3.6.4 The Macroscreen Platform: Sensing cardiovascular disease associated microenvironment Lieve Temmerman, Carim Maastricht University, The Netherlands
15:30 – 15:45 S.3.6.5 Endothelial C-Type Natriuretic Peptide Acts on Perivascular Mast Cells to Inhibit
Postischemic Vascular Inflammation and Thrombosis Wen Chen, University of Wuerzburg, Germany
27ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
14:15 – 15:45 CONCURRENT SESSION ROOM 2.1 Colorado Session 3.7 Resistance arteries Ed van Bavel, University of Amsterdam, The Netherlands (chair) Nicola Brown, University of Sheffield, United Kingdom (chair)
14:15 – 14:45 S.3.7.1 The negative side of life – the calcium activated chloride conductances in vascular smooth muscle cells.
Christian Aalkjaer, Aarhus University, Denmark 14:45 – 15:00 S.3.7.2 Collagen IV Is Required for Regulation of Endothelial Cell Mediated
Vascular Function Sarah McNeilly, University of Glasgow, United Kingdom 15:00 – 15:15 S.3.7.3 Preserved Cardiovascular Homeostasis Despite Blunted Acetylcholine-
induced Dilation in Mice with Endothelial Muscarinic M3 Receptor Deletion Cor de Wit, Universität Lübeck, Germany 15:15 – 15:30 S.3.7.4 The Effect of Two Weeks of Leg Immobilisation and Intense Aerobic
Exercise Training on Endothelial Function Nicolai Rytter, University of Copenhagen, Denmark
15:30 – 15:45 S.3.7.5 The Conducted Response as an Electrical Pliant Process: Reimagining Cell
Signaling in the Arterial Wall Donald Welsh, University Of Western Ontario, Canada
15:45 – 16:15 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 16:15 – 17:00 PLENARY ROOM 0.4/0.5 Brussels/Paris – Keynote Session 3.8 Clinical imaging of vascular disease Judith Sluimer, Maastricht University, The Netherlands (chair) Jozef Dulak, Jagellonian University, Poland (chair)
16:15 – 17:00 Clinical imaging of vascular disease Keynote: Dave Newby, Edinburgh University, United Kingdom 17:00 – 18:30 Poster Session, Exhibition and drinks (Exhibition Area Level 0 and 1) 18:30 – 19:30 make your way to the conference Party 19:30 – Conference Party and Dinner – Rebelle open ended
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Thursday, April 18, 2019 8:30 – 9:10 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 4.1 EVBO lecture
Friedmann Kiefer, Max Plank inst. for molecular Biomedicine, Münster, Germany (chair) Judith Sluimer, Maastricht University, The Netherlands (chair)
8:30 – 9:10 Using multispectral genetic mosaics to enlighten endothelia heterogeneity during angiogenesis Rui Miguel Benedito, CNIC Madrid, Spain
9:10 – 9:15 Quick break to change session rooms 9:15 – 10:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 4.2 Endothelial metabolism and mitochondrial function in
angiogenesis Ferdinand Le Noble, Karlsruhe Institue of Technology KIT, Germany (chair) Stephan Huveneers, Academic Medical Center Amsterdam, The Netherlands (chair)
9:15 – 9:35 S.4.2.1 Metabolite signaling in the vascular endothelium Michael Potente, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany 9:35 – 9:55 S.4.2.2 Developmental and tumor angioegnesis requires changes in endothelial cell mitochondrial shape Luca Scorrano, University of Padova, Italy 9:55 – 10:15 S.4.2.3 Redox metabolism in angiogenesis Massimo Santoro, University of Padova, Italy 10:15 – 10:30 S.4.2.4 Endothelial-specific Deletion of Autophagy Protein 5 attenuates ischemia-related
Angiogenesis David Sprott, TU Dresden, Germany 9:15 – 10:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 4.3 Vascular drug targeting Jan Kamps, UMC Groningen, The Netherlands (chair) Fional Wilkinson, Manchester Metropolitan University, United Kingdom (chair)
9:15 – 9:45 S.4.3.1 Editing gene expression in endothelial cells in vivo using nanoparticle-directed siRNA and Cas9 delivery
James Dahlman, Georgia Institute of Technology, Atlanta, USA 9:45 – 10:00 S.4.3.2 Targeted liposomal delivery of NF-_B siRNA to endothelial cells abrogates anti-
MPO antibody-induced glomerulonephritis Jan Kamps, UMC Groningen, The Netherlands
10:00 – 10:15 S.4.3.3 Unraveling the selective accumulation of highly unusual liposomes to the blood
brain barrier in embryonic zebrafish Gabriela Arias Alpízar, Leiden University, The Netherlands
10:15 – 10:30 S.4.3.4 Tumour vascular normalisation through inhibition of LRG1 improves the
microenvironment and augments immunotherapy John Greenwood, University College London, United Kingdom
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10:30 – 11:00 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 11:00 – 11:45 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 4.4 Awards Boy Houben, Maastricht University, The Netherlands (chair) Henning Morawietz, TU Dresden, Germany (chair)
11:00 – 11:45 ESM Malpighi Award Lecture: Akos Koller: Going with the flow in microcirculation Akos Koller, University of Physical Education, Budapest, Hungary 11:45 – 12:15 JVR / ESM Award lecture: Lydia Sorokin: The role of endothelial laminins in vascular function Lydia Sorokin, University of Muenster, Germany 12:15 – 12:30 Servier Award / Travel and Poster Awards & Closing 12:30 * Departure
30 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Awards1. Malpighi Lecture
This is the most prestigious award of the European Society for Microcirculation (ESM). It is given to an individual with an internationally outstanding reputation in any field of microcirculation and microvascular research. The individual will deliver the prestigious Malpighi Lecture at the forthcoming ESM meeting in Maastricht, NL, April, 15-18, 2019 and will receive the Gold Malpighi Medal and a life-long Membership of the ESM.
The Malpighi Award Committee is constituted by: the President, the Secretary-General, the Treasurer, one other representative of the ESM Executive Committee and the last two Awardees (if available). Voting is by secret ballot.
The 2019 ESM - Malpighi Award winner is: Prof. dr. Akos Koller (Budapest, Hungary). He will deliver his award lecture (Going with the flow in microcirculation) on Thursday April 18, 11:00h.
2. The Journal of Vascular Research (JVR/ESM) Award
The Journal of Vascular Research (JVR/ESM) Award and Lecture aims to spotlight important and growing fields of research, with high impact for vascular biology and the microcirculation with the goal of giving an award to one of the most prominent researchers in the field.
The 2019 JVR-ESM Award winner is: Prof. dr. Lydia Sorokin (Muenster, Germany). She will deliver her award lecture on Thursday April 18, 11:45h.
3. Servier Award for Microcirculation
This award is offered by SERVIER in partnership with the European Society for Microcirculation for an outstanding publication on microcirculation/vascular biology in basic or clinical research (4000 Euro). The proposed publication must be original research, of international relevance and impact and be consistent with the main objectives of the ESM.
The committee for the Servier Award in Microcirculation includes: the President, Secretary-General, Treasurer, one other representative of the ESM Executive Committee and the last two Servier Awardees (if available). Voting is by secret ballot.
The 2019 Servier Award winner is: dr. Tamara Girbl (London, UK), based on the paper: Girbl et al, Immunity 2018: 49, 1062–1076. Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis. She will receive the award on Thursday April 18.
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Awards4. EVBO Lecture Award
The EVBO Lecture is awarded by the Council every 2 years at the EVBO conference, where the lecturer receives reimbursement of registration and travel costs to the conference. Awardees must be members of the EVBO (application for membership can be made online). The Prize is awarded to a young scientist within 10 years of PhD who, in the judgment of the awards Committee, has published work of a high standard with exceptional promise to become an international leader in vascular science. The list of candidates is drawn up by the Medals Committee from names put forward by the EVBO Council members, and the meeting hosts, the winner is selected by this judging panel and ratified by the council.
The EVBO lecture will be delivered this year by Rui Miguel Benedito (Spain), who will be speaking in Session 4.1 on Thursday April 18, at 8:30am.
5. EVBO Medal Award
The EVBO Medal is awarded by the European Vascular Biology Organisation to an individual who, in the judgment of the EVBO Council, has made a sustained, outstanding contribution to the development of vascular science and whose research has had a significant international impact. A list of candidates is drawn up by the Medals Committee from names put forward both by the EVBO Council, and following an invitation for nominations from the membership. Taking into consideration, the meeting hosts and their programme, all Council members then take a vote.
The EVBO medal lecture will be delivered this year by Professor Elisabetta Dejana, Institute Of Molecular Oncology Foundation, Italy, at the forthcoming EVBO meeting in Maastricht, April, 15-18, 2019, during Session 1.1 on Monday April 15, 13:15.
6. EVBO Travel AwardsThe European vascular biology organization will be awarding 10 travel awards. www.evbo.org.
7. ESM Travel AwardsThe European Society of Microcirculation will be awarding 5 Early Career Investigators Travel Awards and 5 Early Career Investigator Travel Awards for less-developed countries.
8. ESM Poster AwardsESM will be awarding 5 poster awards. www.esm.org
9. MiVaB Travel GrantsThe Dutch Society for Microcirculation and Vascular biology awards to 3 best presentations.
10. German Microcirc Society (GfMVB) Poster Awards
The German Microcirc Society (GfMVB) will be awarding 3 poster awards.
www.gmfvb.com
32 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Social EventsWelcome Reception
Monday April 15, 2019
Time : 18:00 – 19:00
Address: Maastricht Town Hall,
Markt 78, 6211 CL Maastricht
On Monday evening you are invited between
18:00 – 19:00 by the city of Maastricht to attend
the ESM-EVBO 2019 welcome-reception at the
Maastricht historic town hall. (This venue can take a maximum of 300 delegates (based on
first come, first serve basis); please tick the box during your registration).
In Dutch the town hall is called “Stadhuis” and it’s located in the centre of Maastricht, sited
on the Markt. The building was designed by Pieter Post in the 17th century in the style of
Dutch classicism.
Getting there
There are no conference shuttle buses available.
• A taxi from MECC to the town hall will take approx 10-15 min depending traffic
(cost approx 15 EUR).
• You can use one of the public buses, running every 10 min (line 1, 6, 10 or 57)
which will take approx 20-25 min (cost approx 2.00 EUR, tickets can be purchased
directly in the bus).
During the remaining evening, you are free to enjoy Maastricht nightlife with its 400 bars
and restaurants.
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Conference Party Rebelle Maastricht
Wednesday April 17, 2019
Time : 19:30 – open ended
Address: Rebelle Maastricht, Kesselskade 43,
6211 EN Maastricht, Price: 75 EUR
Join us for the Conference Dinner and Party
@ Rebelle Maastricht. Rebelle is located in
the 17th century Augustinian church, in the
city center, on the banks of the river Maas.
This historical monument has a more than
impressive interior with a special appearance
by its high ceilings, great windows and was
recently transformed in a party venue.
In 2018 they were awarded with the price of
best party venue in the South! Following an
opening drink and a surprise performance
typical for Maastricht, you can enjoy
different dishes, served at various buffets.
As a grand dessert the party will open by a
SPECTACULAR performance in Maastricht
style. Let’s rock ESM-EVBO !!!
Getting there
There are no conference shuttle buses available.
• a taxi from MECC to Rebelle will take approx 10-15 min depending traffic (cost
approx 15 EUR)
• Use one of the public buses, running every 10 min (line 1, 5, 15 or 57) which will
take approx 20-25 min (cost approx 3.00 EUR, tickets can be purchased directly in
the bus, no cash).
34 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Early Career Scientist BBQ and Party
Tuesday April 16, 2019
Times:19:00 -open ended
Address: Stayokay Maastricht,
Maasboulevard 101, 6211 JW Maastricht
Price: 35 EUR
Limited to 150 people
A networking extravaganza!!
Kick-starting the night off will be a lovely BBQ spread on the balcony overlooking the Maas.
Providing the perfect opportunity to socialise and network with other young investigators
within the field; before having your brains and wits challenged by our all-encompassing
Pub Quiz. With questions ranging from the mundane to the extraordinary, all knowledge will
be tested. The night will be closed off with a party at the Stayokay in celebration of the new
friendships made.
Getting there
• A taxi from MECC to Stayokay will take approx. 10mins depending on traffic (cost
approx. 12 EUR) or you can use the public transport, Buses running every 10
minutes (line 1, 5, 10 or 57) which will take approx. 25-30 min (cost approx. 3.00
EUR, tickets can be obtained directly on the bus, no cash).
• Depending on the weather, there is an opportunity to walk by foot (approx. 30min)
or cycle (approx. 10min).
Join us for an early 5km run through Maastricht on Tuesday April 16, 2019!
Do you want to discover Maastricht in a different
way? On Tuesday April 16th, we are organizing
a 5km run through the city. You will discover all
the beautiful hidden corners of Maastricht and
exercise at the same time. Meeting point is at the hostel StayOkay (Maasboulevard 101,
Maastricht) at 7am, sharp! See you there.
35ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Poster Numbers
Presenting Author Names
Paper Title
TUEP001 Renée Tillie PDGF-B Retention Motif Deletion Has Mural Cell-Independent Effects Including Leukocytosis And Increased Murine Atherosclerotic Plaque Stability Due To Macrophage Apoptosis And Decreased MMP Activity
TUEP002 Maria Filippova Atypical adhesion molecule T-cadherin is a novel regulator of pericyte function.
TUEP003 Emmanuel Nwadozi
Nutrient-Overload Induces Leptin Production by Skeletal Muscle Pericytes: Implications for Capillary Remodelling
TUEP004 Józef Dulak miR-378a influences vascularization in skeletal muscles
TUEP005 Nicola Jane Brown Breast Cancer Metastasis To Bone: The Role Of The Perivascular Niche In Regulating Tumour Cell Dormancy
TUEP007 Evangelia Papadimitriou
Interaction of moesin with ανβ3 integrin regulates endothelial cell migration
TUEP008 Sohni Ria Bhalla Wnt5A Dependent Revascularisation After Ischemia Is SRPK1 Dependent
TUEP009 Ito Puruhito Efficacy of Transdermal CO2 Administration Using the D’OXYVA® Medical Device to Treat Diabetic Foot Ulcers
TUEP011 Alexandra Hoeh Leucine-rich alpha-2-glycoprotein-1 Disrupts Vessel Maturation in Developmental Retinal Angiogenesis
TUEP012 Alexandra Njegic Essential Role for Plasma Membrane Calcium ATPase 1 in Angiogenesis
TUEP013 Valeria Mastrullo Human Vascular Pericytes Express a Circadian Rhythmicity
TUEP014 Katarina Spiranec Spes
Distinct atrial natriuretic peptide-induced cGMP signalling pathways in astrocytes and pericytes attenuate retinal pathological neovascularization
TUEP015 Fabian Hahner The NADPH oxidase Nox4 promotes differentiation from induced pluripotent stem cells into endothelial cells
TUEP016 Caroline Kniebs Three-Dimensional Tumor Model Based on Alginate Beads in vitro
TUEP017 Ilaria Aurigemma Determining the role of the transcription factor TBX1 in endothelial cell differentiation
TUEP018 Tim Schader Nox4 promotes angiogenesis by oxidation of HDAC4 and abrogated MEF2A repression
TUEP019 Laia Gili Solé Effect of 3D Dynamic Culture on Human Stromal Vascular Fraction Cell Composition
TUEP020 Vincent Van Duinen
Perfused 3D angiogenic sprouting assay of iPSC-derived endothelial microvessels in vitro
PostersTuesday, April 16, 2019
36 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
TUEP021 Cyrine Ben Dhaou Regulation of tumor angiogenesis by chemerin and its receptors CHEMR23
TUEP022 Nikita Chernomorets
Epidermal growth factor in the treatment of trophic ulcers in the neuropathic form of diabetic foot syndrome.
TUEP023 Heidi Pulkkinen Crosstalk of VEGF-, BMP- and Hippo-signaling in Angiogenesis
TUEP024 Harsh Patolia Agent-Based Model Simulates Effect of Dose-Dependent Inhibition of Angiogenesis by Increasing Secretion of Extracellular Soluble PDGF Receptor-Beta by Pericytes
TUEP025 William Jackson High Fat Feeding Decreases Vascular Density in Rat Mesenteric Perivascular Adipose Tissue
TUEP026 Hermann J. Genn Influencing microcirculation in horses
TUEP027 Mahdieh Heydarigoojani
Thrombin receptor activating peptide (TRAP-6), promotes proliferation of human umbilical vein endothelial cell (HUVEC)
TUEP028 Adeline Yoke Yin Chia
Discovering potential acetylcholinesterase inhibitors using molecular docking against Alzheimer’s Disease and Angiogenesis
TUEP029 Fabiana Baganha Human IgG1 phosphorylcholine antibody reduces vein graft remodelling, intraplaque angiogenesis and intraplaque hemorrhage
TUEP030 Melissa King Influence of Bemer Blanket Technology on Pain Measures, Biomechanics and Serum Biomarkers in Horses with Back Pain
TUEP031 Gangqi Wang Shear stress regulates endothelial glycocalyx hyaluronan biosynthesis through HAS2 and metabolic regulation of its substrates
TUEP032 Christina Warboys Inflammatory Activation of Endothelial Cells Induced by Disturbed Flow is Regulated by Frizzled-4 and β-catenin via a Non-canonical Pathway
TUEP033 Patricia Mccallinhart
Human Cardiac Microvascular Endothelial Cell Stiffness and Adhesion to Extracellular Matrix Proteins in Type 2 Diabetes
TUEP034 Diana Schrick A novel approach of platelet function test to identify non-matured platelets having increased aggregatory effect
TUEP035 Cini Mathew John Targeting the endothelium with KCa channel activator SKA-31, improves vascular function and does not up regulate T cell activity in a rodent model of T2DM
TUEP036 Maria Globisch Dynamic molecular signatures of endothelial cells during postnatal development of the blood-brain barrier
TUEP037 María Del Carmen Ocaña
Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?
TUEP038 Jana Horvathova Simultaneous inhibition of glycolysis and multikinase receptor activity can have an additive effect on endothelial cell proliferation and migration
TUEP039 Camilla Hansen Mitochondria in skeletal muscle microvascular endothelial cells and the influence of glucose availability
37ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
TUEP021 Cyrine Ben Dhaou Regulation of tumor angiogenesis by chemerin and its receptors CHEMR23
TUEP022 Nikita Chernomorets
Epidermal growth factor in the treatment of trophic ulcers in the neuropathic form of diabetic foot syndrome.
TUEP023 Heidi Pulkkinen Crosstalk of VEGF-, BMP- and Hippo-signaling in Angiogenesis
TUEP024 Harsh Patolia Agent-Based Model Simulates Effect of Dose-Dependent Inhibition of Angiogenesis by Increasing Secretion of Extracellular Soluble PDGF Receptor-Beta by Pericytes
TUEP025 William Jackson High Fat Feeding Decreases Vascular Density in Rat Mesenteric Perivascular Adipose Tissue
TUEP026 Hermann J. Genn Influencing microcirculation in horses
TUEP027 Mahdieh Heydarigoojani
Thrombin receptor activating peptide (TRAP-6), promotes proliferation of human umbilical vein endothelial cell (HUVEC)
TUEP028 Adeline Yoke Yin Chia
Discovering potential acetylcholinesterase inhibitors using molecular docking against Alzheimer’s Disease and Angiogenesis
TUEP029 Fabiana Baganha Human IgG1 phosphorylcholine antibody reduces vein graft remodelling, intraplaque angiogenesis and intraplaque hemorrhage
TUEP030 Melissa King Influence of Bemer Blanket Technology on Pain Measures, Biomechanics and Serum Biomarkers in Horses with Back Pain
TUEP031 Gangqi Wang Shear stress regulates endothelial glycocalyx hyaluronan biosynthesis through HAS2 and metabolic regulation of its substrates
TUEP032 Christina Warboys Inflammatory Activation of Endothelial Cells Induced by Disturbed Flow is Regulated by Frizzled-4 and β-catenin via a Non-canonical Pathway
TUEP033 Patricia Mccallinhart
Human Cardiac Microvascular Endothelial Cell Stiffness and Adhesion to Extracellular Matrix Proteins in Type 2 Diabetes
TUEP034 Diana Schrick A novel approach of platelet function test to identify non-matured platelets having increased aggregatory effect
TUEP035 Cini Mathew John Targeting the endothelium with KCa channel activator SKA-31, improves vascular function and does not up regulate T cell activity in a rodent model of T2DM
TUEP036 Maria Globisch Dynamic molecular signatures of endothelial cells during postnatal development of the blood-brain barrier
TUEP037 María Del Carmen Ocaña
Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?
TUEP038 Jana Horvathova Simultaneous inhibition of glycolysis and multikinase receptor activity can have an additive effect on endothelial cell proliferation and migration
TUEP039 Camilla Hansen Mitochondria in skeletal muscle microvascular endothelial cells and the influence of glucose availability
TUEP040 Tatyana Grishacheva
The photodynamic effects on the microvasculature vessels
TUEP042 Silvia Martin Almedina
Investigating the Role of KIF11 in the Lymphatic Function of MCLID Patients
TUEP043 Kitti Ajtay Fetal Breathing Movements and Pulmonary Lymphatics Function Together to Prepare the Lung for Inflation at Birth
TUEP044 Christina Karapouliou
Functional Studies on the EPHB4 Signalling Pathway in Patients with Generalised Lymphatic Dysplasia
TUEP045 Zoltan Jakus Nucleoside-Modified VEGFC mRNA Induces Organ-Specific Lymphatic Growth and Reverses Experimental Lymphedema
TUEP046 Marie Ebroin New considerations of lymphatic endothelial cells as key players of the pro-tumoral microenvironment
TUEP047 Sonia Martial Unexpected Effects of Photontherapy and Protontherapy on VEGFC Production and Tumor Aggressiveness in Different Medulloblastoma Subgroups
TUEP048 Lionel Gillot Modification of lymph node microenvironment during tumor progression
TUEP049 James Oo Modulation of endothelial chromatin remodelling complexes by long non-coding RNAs
TUEP050 Candidate Eleni Liapi
Role of 5’GluCTC-tRNA half in human cardiac microvascular endothelial function
TUEP051 J Hung A Novel Macrophage Long Non-Coding RNA Expressed in Human Atherosclerosis
TUEP052 Agnieszka Jazwa-Kusior
Cardiac macrophages in myocardial infarction - role of heme oxygenase 1
TUEP053 Francesca Vacante Characterization of the LncRNA miR143HG in the pathophysiology of atherosclerosis
TUEP054 Shiping He microRNA-214 is a novel player in inflammatory smooth muscle cell differentiation and angioplasty restenosis
TUEP055 Gokhan Pehlivan Association of Skin Microvascular Function with Pulsatile and Resistive Hemodynamics
TUEP056 Sam Thomas Acute aerobic exercise increases systemic skin microvascular functional responses to post-occlusive reactive hyperaemia
TUEP057 Paulina Kowalewska
Deletion of Connexin 40 but not KIR2.1 Eliminates the Microvascular Response to Oxygen in Mouse Skeletal Muscle
TUEP058 Jo De Mey The Many Faces of Endothelium-Dependent Relaxation in Resistance Arteries from Patients with Residual Cardiovascular Disease
38 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
TUEP059 Daniel Henrion Flow-mediated vasodilatation in the mouse involves unliganted membrane, but not nuclear, estrogen receptor alpha
TUEP060 Angel Luis Armesilla
Plasma Membrane Calcium ATPase 4 gene expression is downregulated in pulmonary artery endothelial cells treated with inducers of pulmonary arterial hypertension
TUEP061 Yiannis Dimakopoulos Mr Konstantinos Giannokostas
Shear-induced NO/cGMP pathway and its impact on intravascular functionality.
TUEP062 Dorien De Munck Autophagy in vascular smooth muscle cells regulates large artery contractility and compliance in young C57Bl6 mice.
TUEP063 Myrthe van der Bruggen
In-Vitro Characterization of Mouse Carotid Artery Mechanics by Dynamic Biaxial Pressure-Myography
TUEP064 Arthur Leloup Vascular smooth muscle cell contraction and relaxation as a critical regulator of large artery compliance
TUEP065 Alexei Muravyov Microrheological behavior of red blood cells under the influence of gastransmitters as a model of the paracrine regulation in the vascular system
TUEP066 Brenda R Kwak Primary cilia affect the endothelial response to aneurysmal wall shear stress
TUEP067 Emmanouil Solomonidis
Single Cell RNA-Sequencing Reveals Plasmalemma Vesicle-Associated Protein (PLVAP) as a Novel Target with a Role in New Blood Vessel Formation in the Ischaemic Heart
TUEP068 Rolando Szilveszter Matos
Development of an Ex-vivo Model of Vascular Remodelling
TUEP069 Cai Astley Resveratrol-Loaded Nanostructured Lipid Carriers Restore Dilator Function Following Acute Pressure Elevation, Ex Vivo.
TUEP070 Marie Lang The Effects of Methotrexate on the Vascular Endothelium
TUEP071 Christian Ramakers Perfusable 3D angiogenesis in high throughput microfluidic culture platform
TUEP072 Christian Ramakers High-Throughput permeability assay on perfused 3D microvessels in vitro
TUEP073 Angelina Pavlic Sphingomyelin phosphodiesterase in targeted treatment of vascular calcification
TUEP074 Anna Maria Gdula Effect of Dual Purinoreceptor-Dependent Strategy on Endothelial Permeability and Cells Condition
TUEP076 Ziva Melik The effect of caffeine on cutaneous microcirculation in women
39ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
TUEP059 Daniel Henrion Flow-mediated vasodilatation in the mouse involves unliganted membrane, but not nuclear, estrogen receptor alpha
TUEP060 Angel Luis Armesilla
Plasma Membrane Calcium ATPase 4 gene expression is downregulated in pulmonary artery endothelial cells treated with inducers of pulmonary arterial hypertension
TUEP061 Yiannis Dimakopoulos Mr Konstantinos Giannokostas
Shear-induced NO/cGMP pathway and its impact on intravascular functionality.
TUEP062 Dorien De Munck Autophagy in vascular smooth muscle cells regulates large artery contractility and compliance in young C57Bl6 mice.
TUEP063 Myrthe van der Bruggen
In-Vitro Characterization of Mouse Carotid Artery Mechanics by Dynamic Biaxial Pressure-Myography
TUEP064 Arthur Leloup Vascular smooth muscle cell contraction and relaxation as a critical regulator of large artery compliance
TUEP065 Alexei Muravyov Microrheological behavior of red blood cells under the influence of gastransmitters as a model of the paracrine regulation in the vascular system
TUEP066 Brenda R Kwak Primary cilia affect the endothelial response to aneurysmal wall shear stress
TUEP067 Emmanouil Solomonidis
Single Cell RNA-Sequencing Reveals Plasmalemma Vesicle-Associated Protein (PLVAP) as a Novel Target with a Role in New Blood Vessel Formation in the Ischaemic Heart
TUEP068 Rolando Szilveszter Matos
Development of an Ex-vivo Model of Vascular Remodelling
TUEP069 Cai Astley Resveratrol-Loaded Nanostructured Lipid Carriers Restore Dilator Function Following Acute Pressure Elevation, Ex Vivo.
TUEP070 Marie Lang The Effects of Methotrexate on the Vascular Endothelium
TUEP071 Christian Ramakers Perfusable 3D angiogenesis in high throughput microfluidic culture platform
TUEP072 Christian Ramakers High-Throughput permeability assay on perfused 3D microvessels in vitro
TUEP073 Angelina Pavlic Sphingomyelin phosphodiesterase in targeted treatment of vascular calcification
TUEP074 Anna Maria Gdula Effect of Dual Purinoreceptor-Dependent Strategy on Endothelial Permeability and Cells Condition
TUEP076 Ziva Melik The effect of caffeine on cutaneous microcirculation in women
TUEP077 Maud Martin How to build a polarized endothelial cell: non-centrosomal microtubules and not the centrosome control endothelial cell polarity and sprouting angiogenesis
TUEP078 Maximiliano Arata Coagulation factor Xa promotes metastasis through endothelial cells activation
TUEP079 Anoek van Leeuwen
Downregulation of Tie2 Induces Microvascular Leakage in Mice
TUEP080 Lucie E Bourne N-acetylcysteine Limits Arterial Medial Calcification But Preserves Bone Formation
TUEP081 Daniëlle Coenen PDE3 and -5 Inhibition Differentially Affects Platelet Function under Hemostatic and Inflammatory Conditions
TUEP082 James Walker Eph-Ephrin Signalling Patterns Early Venous Valve Formation
TUEP083 Anton Kutikhin Calcium phosphate bions promote intimal hyperplasia in intact arteries even upon normolipidemic conditions by causing endothelial injury through lysosome-dependent cell death
TUEP084 Martina Mihalj Short Term Blockade of Angiotensin II Type 1 Receptor by Losartan Effects on Blood Leukocyte Subpopulations’ ROS and RNS Levels in Sprague-Dawley Rats
TUEP085 Francesca Del Gaudio Daniel V. Oliveira
Characterization of a Novel CADASIL-like Mutation in the Notch3 Receptor
TUEP086 Xiaohua Guo Mdia1 is Crucial for Advanced Glycation End Product-In-duced Endothelial Hyperpermeability
TUEP088 Franziska Werner Autocrine C-type natriuretic peptide signalling improves macrovascular endothelial functions and prevents arterial stiffness
TUEP090 Mieke Karel Injury-induced vascular changes and thrombus activity after aspirin or rivaroxaban treatment in mice
TUEP091 Írisz Szabó Antagonism of Prostaglandin Signaling Involving FP-Receptors Inhibits the Evolution of Spreading Depolarization in Cerebral Ischemia
TUEP092 Timara Kuiper Protein Tyrosine Kinase Activity Profiling Reveals Novel Signal Transduction Pathways of LPS-Induced Inflammatory Responses in Endothelial cells in vitro
TUEP093 Anne-marie Fors Connolly
MMP9 Associates with Endothelial Glycocalyx Degradation During Haemorrhagic Fever with Renal Syndrome
TUEP094 Kapka Miteva Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression
TUEP095 Pranitha Kamat Machine Learning to Automatically Identify and Evaluate Intimal Hyperplasia in Histological Sections
TUEP096 Pranitha Kamat Adipose Derived Mesenchymal Stem Cell Delivered Endothelial Protection during Graft Vasculopathy
40 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
TUEP097 Michael R McDermott
Aortic Valve Regurgitation Causes a Mild Improvement in Coronary Flow Velocity Reserve in the Type 2 Diabetic db/db Mouse
TUEP098 Geoffrey Van den Bergh
Using a Mouse Model of Vascular Media Calcification to Unravel the Pathophysiology Behind Arterial Stiffness
TUEP099 Nicola Edwards Improving Stratification of Cardiovascular Risk in Systemic Lupus Erythematosus using Endothelial Microvesicles as Novel Biomarkers
TUEP100 Mohamed Essameldin Abdelgawad
Novel Optimized Cell Culture Medium for Growth and Maintenance of Endothelial-like Cells and Endothelial Progenitor Cells with minimal serum
TUEP101 Mohamed Essameldin Abdelgawad
Development of a Novel Angiogenic Score for Early Detection of Hepatocellular Carcinoma among High-risk Hepatitis C Virus Patients
TUEP102 ASMA ALONAZI Potential Role for G Protein Coupled Receptor Kinase 2 in Vasoconstrictors-stimulated Vascular Smooth Muscle Cell Proliferation via MAPK/ERK Signalling Pathway
TUEP103 Luís Miguel Cardoso Dos Santos
Role of apelin in vascular smooth muscle cell phenotypic transition: a proatherogenic factor for atherosclerosis
TUEP104 László Hejjel Autonomic Actions of Physical Vascular Therapy in Ischemic Heart Disease Patients by Heart Rate Variability Analysis
TUEP105 Elena Gavrilova Evaluation of the Vasomotor Function of the Microvessels Using Laser Doppler Flowmetry in Critically ill Patients as a Way to Determine Functional Reserves
TUEP106 Zulfia Zaripova Gravitational Therapy Using Dynamic Inversion Table to Improve Microcirculation and Increase Exercise Tolerance in Healthy Athletes
TUEP107 Ksenija Cankar Nutritional and functional blood flow in glabrous and nonglabrous skin: can they be separately measured
TUEP108 Wolf Balliel PEMF in REHAB at Extreme Sport - Special Case
TUEP109 Wolf Balliel Specific PEMF-Treatment in hypertension therapy - Cases
TUEP110 David Low The Effects of Acute Exercise on Thermal Sensory Function
TUEP111 Sabrina Boumendjel
Genetic polymorphism of apolipoprotein E in hemorrhagic stroke: study case-control
TUEP112 Olivia WaringHan JinDr Pieter GoossensDr Marjo DonnersProf. Erik Biessen
Dissecting the Link Between Microcalcification and Macrophage-Led Inflammation in the Vasculature
TUEP113 Ilaria Passalacqua A Potential Role for Extracellular Vesicle-Mediated Communication from Smooth Muscle Cells to Endothelial Cells in Development of Human Pulmonary Arterial Hypertension
41ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
TUEP097 Michael R McDermott
Aortic Valve Regurgitation Causes a Mild Improvement in Coronary Flow Velocity Reserve in the Type 2 Diabetic db/db Mouse
TUEP098 Geoffrey Van den Bergh
Using a Mouse Model of Vascular Media Calcification to Unravel the Pathophysiology Behind Arterial Stiffness
TUEP099 Nicola Edwards Improving Stratification of Cardiovascular Risk in Systemic Lupus Erythematosus using Endothelial Microvesicles as Novel Biomarkers
TUEP100 Mohamed Essameldin Abdelgawad
Novel Optimized Cell Culture Medium for Growth and Maintenance of Endothelial-like Cells and Endothelial Progenitor Cells with minimal serum
TUEP101 Mohamed Essameldin Abdelgawad
Development of a Novel Angiogenic Score for Early Detection of Hepatocellular Carcinoma among High-risk Hepatitis C Virus Patients
TUEP102 ASMA ALONAZI Potential Role for G Protein Coupled Receptor Kinase 2 in Vasoconstrictors-stimulated Vascular Smooth Muscle Cell Proliferation via MAPK/ERK Signalling Pathway
TUEP103 Luís Miguel Cardoso Dos Santos
Role of apelin in vascular smooth muscle cell phenotypic transition: a proatherogenic factor for atherosclerosis
TUEP104 László Hejjel Autonomic Actions of Physical Vascular Therapy in Ischemic Heart Disease Patients by Heart Rate Variability Analysis
TUEP105 Elena Gavrilova Evaluation of the Vasomotor Function of the Microvessels Using Laser Doppler Flowmetry in Critically ill Patients as a Way to Determine Functional Reserves
TUEP106 Zulfia Zaripova Gravitational Therapy Using Dynamic Inversion Table to Improve Microcirculation and Increase Exercise Tolerance in Healthy Athletes
TUEP107 Ksenija Cankar Nutritional and functional blood flow in glabrous and nonglabrous skin: can they be separately measured
TUEP108 Wolf Balliel PEMF in REHAB at Extreme Sport - Special Case
TUEP109 Wolf Balliel Specific PEMF-Treatment in hypertension therapy - Cases
TUEP110 David Low The Effects of Acute Exercise on Thermal Sensory Function
TUEP111 Sabrina Boumendjel
Genetic polymorphism of apolipoprotein E in hemorrhagic stroke: study case-control
TUEP112 Olivia WaringHan JinDr Pieter GoossensDr Marjo DonnersProf. Erik Biessen
Dissecting the Link Between Microcalcification and Macrophage-Led Inflammation in the Vasculature
TUEP113 Ilaria Passalacqua A Potential Role for Extracellular Vesicle-Mediated Communication from Smooth Muscle Cells to Endothelial Cells in Development of Human Pulmonary Arterial Hypertension
WEDP001 Brenda R Kwak Gender differences and similarities in the resolution of intraluminal thrombosis in a rat aneurysm model
TUEP114 Thomas Sarazin TSP-1:CD47 Orthosteric Antagonist TAX2 Peptide hasPlatelet Anti-aggregating and Antithrombotic Activities
WEDP002 Danielle Kerkhofs Vascular cognitive impairment in experimental hypertension: the microglial culprit
WEDP003 Clifton Houk Characterization of Germinal Matrix Vasculature in the Early Postnatal Mouse Brain
WEDP004 Marina Leardini-Tristão
The impact of early physical exercise on brain microcirculation, synaptic proteins and cognitive function in a chronic model of cerebral hypoperfusion
WEDP005 Takashi Koizumi Impact of Diabetes on Hypertension-Induced Cerebral Small Vessel Disease
WEDP006 Anita Matic Angiotensin II supplementation by miniosmotic pumps reduces the level of oxidative stress induced by high dietary salt intake in rat microcirculation
WEDP007 Johan Van De Voorde
Search for the source of the retinal relaxing factor
WEDP008 Christian Ramakers BBB on-a-chip: a 3D in vitro model of the human blood brain barrier (BBB)
WEDP009 Donald G. Welsh Lipid Regulation of KIR2.x Channels and the Enabling of Hemodynamic Sensing in Cerebral Arteries
WEDP010 Dorien Hermkens The protective function of intracranial endothelial cells in vascular cognitive impairment
WEDP011 Karin Wårdell Cerebral microcirculation recording with laser Doppler flowmetry in neurosurgery
WEDP012 Chonticha Wongchaiya
Pomelo Extract Attenuates Cerebral Endothelial Dysfunction Through Activating PI3K-Akt-eNOS Pathway in A Rat Model of Type 2 diabetes
WEDP013 Zrinka Mihaljevic Angiotensin II-type 1 Receptor Blockade with Losartan Affects the Expression of Enzymes Involved in Vascular Reactivity and Balance of Vascular Oxidative Stress of Sprague-Dawley Rats
WEDP014 Elizabeth Illingworth
Defining Vegfr3-Tbx1 interactions in brain vascular development
Wednesday, April 17, 2019
42 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
WEDP015 Rajkumar Rajanathan
Abnormal K+-signaling in Cerebral Arteries Disturbs Neurovascular Coupling in Mouse Model for Migraine.
WEDP016 Hanna Jonasson Oxygen Saturation in Skin Microcirculation as a Predictor for Cardiovascular Disease
WEDP017 Sytze Rensma Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study
WEDP018 Wenjie Li Prediabetes and Type 2 Diabetes are Associated with Wider Retinal Arterioles and Venules
WEDP019 Nathalie Obadia Evidence of the TLR4 participation on the impact of metabolic syndrome on brain microcirculation and cognitive function
WEDP020 Wayne Smith Retinal Vessel Caliber and Vessel Reaction to Light Flicker in True Normotensive Young Healthy Black and White Adults: the African-PREDICT Study
WEDP022 Andriana Margariti Establishing human diabetic and cardiovascular disease models in a petri dish through cell reprogramming
WEDP023 Rui Ning Chia Role of Leucine-Rich alpha-2-Glycoprotein 1 (LRG1) in Diabetes-Related Ischaemic Heart Diseases
WEDP024 David Strain The Impact Of Diabetes, Cardiovascular Disease And Weight Change On Microvascular Function; Results Of A Three-Year Longitudinal Observational Study.
WEDP026 Sabrina Köchli Obesity, high blood pressure and physical activity determine vascular phenotype in young children: the EXAMIN YOUTH Study
WEDP027 Mitko Veta Retinal Microvascular Biomarker Extraction on Fundus Images from the Maastricht Study Using Supervised Deep Learning
WEDP028 Ayushi Singh Long Term Cardiac and Vascular Changes in Women with a History of Hypertensive Disorders of Pregnancy: A Case-Control Study
WEDP029 Christina Svensson Cerebral hemodynamics and microcirculatory function in patients with Systemic Lupus Erythematosus
WEDP030 EDUARDO TIBIRICA
Penile Microvascular Endothelial Reactivity in Hypertensive Patients with Erectile Dysfunction: Effects of a Chronic Treatment with Sildenafil
WEDP031 EDUARDO TIBIRICA
Effects of acute postprandial hyperglycemia on microvascular endothelial-dependent vasodilation
WEDP032 Nikita Chernomorets
Gravitational therapy in the complex treatment of patients with complications of diabetes.
WEDP033 Tos TJM Berendschot
Characteristics Of The Retinal Microvasculature In Association With Cardiovascular Risk Markers In Children With Overweight, Obesity And Morbid Obesity
43ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
WEDP015 Rajkumar Rajanathan
Abnormal K+-signaling in Cerebral Arteries Disturbs Neurovascular Coupling in Mouse Model for Migraine.
WEDP016 Hanna Jonasson Oxygen Saturation in Skin Microcirculation as a Predictor for Cardiovascular Disease
WEDP017 Sytze Rensma Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study
WEDP018 Wenjie Li Prediabetes and Type 2 Diabetes are Associated with Wider Retinal Arterioles and Venules
WEDP019 Nathalie Obadia Evidence of the TLR4 participation on the impact of metabolic syndrome on brain microcirculation and cognitive function
WEDP020 Wayne Smith Retinal Vessel Caliber and Vessel Reaction to Light Flicker in True Normotensive Young Healthy Black and White Adults: the African-PREDICT Study
WEDP022 Andriana Margariti Establishing human diabetic and cardiovascular disease models in a petri dish through cell reprogramming
WEDP023 Rui Ning Chia Role of Leucine-Rich alpha-2-Glycoprotein 1 (LRG1) in Diabetes-Related Ischaemic Heart Diseases
WEDP024 David Strain The Impact Of Diabetes, Cardiovascular Disease And Weight Change On Microvascular Function; Results Of A Three-Year Longitudinal Observational Study.
WEDP026 Sabrina Köchli Obesity, high blood pressure and physical activity determine vascular phenotype in young children: the EXAMIN YOUTH Study
WEDP027 Mitko Veta Retinal Microvascular Biomarker Extraction on Fundus Images from the Maastricht Study Using Supervised Deep Learning
WEDP028 Ayushi Singh Long Term Cardiac and Vascular Changes in Women with a History of Hypertensive Disorders of Pregnancy: A Case-Control Study
WEDP029 Christina Svensson Cerebral hemodynamics and microcirculatory function in patients with Systemic Lupus Erythematosus
WEDP030 EDUARDO TIBIRICA
Penile Microvascular Endothelial Reactivity in Hypertensive Patients with Erectile Dysfunction: Effects of a Chronic Treatment with Sildenafil
WEDP031 EDUARDO TIBIRICA
Effects of acute postprandial hyperglycemia on microvascular endothelial-dependent vasodilation
WEDP032 Nikita Chernomorets
Gravitational therapy in the complex treatment of patients with complications of diabetes.
WEDP033 Tos TJM Berendschot
Characteristics Of The Retinal Microvasculature In Association With Cardiovascular Risk Markers In Children With Overweight, Obesity And Morbid Obesity
WEDP034 Kim Gooding Association Between Sural Nerve Conductance Amplitude and Skin Microvascular Responsiveness in Individuals With and Without Type 2 Diabetes Across the Subclinical Neuropathy Range
WEDP035 Irina Tikhomirova Effect of gasotransmitters on erythrocyte microrheological properties in non-diabetic subjects and in patients with type 2 diabetes mellitus
WEDP036 Irina Tikhomirova Microcirculation and red blood cell sensitivity to nitric oxide in 2 type diabetes mellitus
WEDP037 Ingemar Fredriksson
Novel Optical Instrument for Comprehensive Microcirculation Analysis: The Relation to Cardiovascular Risk Factors
WEDP038 Akos Koller Changes in skin microcirculation in response to ischemia and heat in trained and untrained individuals
WEDP039 Ana-Maria Vintila Maximum QT interval as a predictor of atrial fibrillation in a cohort of hypertensive patients
WEDP040 Ana-Maria Vintila QTc dispersion in patients with longstanding arterial hypertension undergoing treatment for major psychiatric disorders - a case-control study
WEDP041 Lukas Streese Exercise regulates DNA methylation of p66Shc gene and improves retinal microvascular phenotype: A cross-sectional and randomized controlled trail (EXAMIN AGE)
WEDP042 Annemarie Wentzel
Heart rate variability and the dynamic nature of the retinal microvasculature: Providing insight into the brain-retina-heart link: The SABPA study
WEDP043 Annemarie Wentzel
Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: The SABPA study
WEDP044 Patricia Pia Wadowski
Sublingual microcirculation in chronic heart failure
WEDP045 Bela Zoltan Debreczeni
Differences in basal levels of microcirculation and reactive hyperemia in the forehead and forearm skin of humans
WEDP046 Junette Mohan Endothelial function in the human cutaneous microcirculation in primary open angle glaucoma.
WEDP047 Ed Eringa Effects of a hypercaloric and subsequent hypocaloric diet on insulin-induced microvascular recruitment, whole-body glucose uptake and adipose tissue lipolysis
WEDP049 Özge Erdem Unaltered Sublingual Microcirculatory Function Throughout ECMO Treatment: a Prospective Longitudinal Observational Study in Critically Ill Neonatal and Pediatric Patients
WEDP050 Neli Kachamako-va-Trojanowska
iPSC-derived Endothelial Cells With Mutation In HNF1A As Model Of Maturity Onset Diabetes Of The Young
44 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
WEDP051 Leoné Malan Stress and neurovascular coupling: A red flag? The SABPA Study
WEDP052 C. Tudorica The influence of altered hormonal pattern on the QTc dispersion in hypertensive diabetic patients
WEDP053 Eliane Wenstedt Sodium-sensitive blood pressure increase in type 1 diabetes is accompanied by impeded skin lymphangiogenesis
WEDP054 Sofia Morsing ADAM10-mediated cleavage of ICAM-1 is required for neutrophil dissociation from the endothelial surface during the final diapedesis step
WEDP055 Jamil Santos Cade NKX2.5 causes endothelial dysfunction in pulmonary arterial hypertension
WEDP056 Klaudia Schossleitner
Tight Junction Adapter Protein Cingulin Plays a Role in Vascular Barrier Function In Vivo
WEDP057 Jos Van Rijssel The GEF Trio reinforces vascular endothelial barrier integrity
WEDP058 Ana Angulo-Urarte Asymmetric endothelial adherens junctions in angiogenesis
WEDP059 Fabian Spill Mechanical Regulation of Autonomously Forming Endothelial Gaps and Cancer Extravasation
WEDP060 Justin Joachim Identification of a novel redox-sensitive kinase that controls endothelial cell permeability
WEDP061 D. Vreeken Downregulation of Endothelial PLXNA4 under Pro-atherosclerotic Conditions Diminishes Vascular Integrity Enabling Monocyte Transendothelial Migration
WEDP062 Martha Leticia Hernandez-Garcia
Development of An Ex Vivo Human Kidney Model to Study The Role of The Endothelium During Sepsis-Induced Acute Kidney Injury
WEDP063 Anna Gajos-Draus Exercise training and dietary nitrite prevent and L-NAME mimics diabetes-mediated upregulation of Nox2/NF-κB and repression of Nox4/Nrf2 in rat heart and kidney
WEDP064 Jan Nagenborg Atherosclerotic Plaque Macrophages Re-Programming Towards An Anti-Atherogenic Phenotype
WEDP065 Irina Tikhomirova The myocardial infarction milieu favours the development of protective T-cell auto-reactivity.
WEDP066 Sai Kiran Reddy Samawar
Role of Arginase II in Hypoxia-Induced Endothelial Inflammation
WEDP067 Amna Shahid Protective Effects of Exercise on Vascular Function are mediated by NADPH Oxidase 4
WEDP068 Jasper Demandt Myeloid HIF-Prolyl Hydroxylase Proteins In Human And Mouse Atherosclerosis: Triplets With Differing Characters
WEDP069 Henning Morawietz
Cigarette smoke impairs the anti-oxidative response by reducing heme levels and inducing Bach1
45ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
WEDP051 Leoné Malan Stress and neurovascular coupling: A red flag? The SABPA Study
WEDP052 C. Tudorica The influence of altered hormonal pattern on the QTc dispersion in hypertensive diabetic patients
WEDP053 Eliane Wenstedt Sodium-sensitive blood pressure increase in type 1 diabetes is accompanied by impeded skin lymphangiogenesis
WEDP054 Sofia Morsing ADAM10-mediated cleavage of ICAM-1 is required for neutrophil dissociation from the endothelial surface during the final diapedesis step
WEDP055 Jamil Santos Cade NKX2.5 causes endothelial dysfunction in pulmonary arterial hypertension
WEDP056 Klaudia Schossleitner
Tight Junction Adapter Protein Cingulin Plays a Role in Vascular Barrier Function In Vivo
WEDP057 Jos Van Rijssel The GEF Trio reinforces vascular endothelial barrier integrity
WEDP058 Ana Angulo-Urarte Asymmetric endothelial adherens junctions in angiogenesis
WEDP059 Fabian Spill Mechanical Regulation of Autonomously Forming Endothelial Gaps and Cancer Extravasation
WEDP060 Justin Joachim Identification of a novel redox-sensitive kinase that controls endothelial cell permeability
WEDP061 D. Vreeken Downregulation of Endothelial PLXNA4 under Pro-atherosclerotic Conditions Diminishes Vascular Integrity Enabling Monocyte Transendothelial Migration
WEDP062 Martha Leticia Hernandez-Garcia
Development of An Ex Vivo Human Kidney Model to Study The Role of The Endothelium During Sepsis-Induced Acute Kidney Injury
WEDP063 Anna Gajos-Draus Exercise training and dietary nitrite prevent and L-NAME mimics diabetes-mediated upregulation of Nox2/NF-κB and repression of Nox4/Nrf2 in rat heart and kidney
WEDP064 Jan Nagenborg Atherosclerotic Plaque Macrophages Re-Programming Towards An Anti-Atherogenic Phenotype
WEDP065 Irina Tikhomirova The myocardial infarction milieu favours the development of protective T-cell auto-reactivity.
WEDP066 Sai Kiran Reddy Samawar
Role of Arginase II in Hypoxia-Induced Endothelial Inflammation
WEDP067 Amna Shahid Protective Effects of Exercise on Vascular Function are mediated by NADPH Oxidase 4
WEDP068 Jasper Demandt Myeloid HIF-Prolyl Hydroxylase Proteins In Human And Mouse Atherosclerosis: Triplets With Differing Characters
WEDP069 Henning Morawietz
Cigarette smoke impairs the anti-oxidative response by reducing heme levels and inducing Bach1
WEDP070 Annemiek Dickhout CCL5 and CXCL4 are Rapidly Internalized in Endothelial Cells
WEDP071 Qiaobing Huang Polydatin ameliorates barrier function in LPS-induced endothelial injury by enhancing the activation of SIRT3
WEDP072 Neena Kalia Intravital imaging of vasculoprotective effects of haematopoietic stem / progenitor cells following myocardial ischaemia-reperfusion injury in the beating mouse heart
WEDP073 Neena Kalia Optimising the myocardial homing and therapeutic efficacy of mesenchymal stem cells using 3d culture and specific sub-populations of bone marrow-derived cells
WEDP074 Amporn Jariyapongskul
Antioxidant and Anti-inflammatory Effects of Alpha-Mangostin on Cerebral Endothelial Dysfunction and Blood Brain Barrier Leakage in Type 2 Diabetic Rats
WEDP075 Natasa Kozina The effect of high salt dietary intake and angiotensin II infusion on activity of antioxidative enzymes in serum of Sprague-Dawley rats
WEDP076 Damian Kloska Nrf2 and ageing affect the nanomechanics of the aorta: in the pursuit of possible mechanisms
WEDP077 Mauro Siragusa Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.
WEDP078 Anne Klotzsche- von Ameln
Myeloid SOCS3-deficiency regulates angiogenesis via enhanced apoptotic endothelial cell engulfment
WEDP079 Nontapat Benjathum
Effect of Naringin on Type 2 Diabetes-Induced Endothelial Dysfunction and Cognitive Impairment Correlates with AGEs/RAGE and NF-κB Inhibition
WEDP080 Ana S. Silva-Herdade
Effects of diabetes on microcirculation in non-ocular tissues: insights into hemodynamic alterations in diabetic retinopathy
WEDP081 Bram van Steen Preferred exit-sides for leukocyte diapedesis, identifying local signalling induced by ICAM-1 clustering upon leukocyte trans endothelial migration
WEDP082 Marjo Donners A disintegrin and metalloprotease adam10 controls endothelial functions in atherosclerosis
WEDP083 Carlota Saldanha Involvement of fibrinogen in the microcirculation
WEDP084 Hugo Huisman The Oxidative Stress Profile and its Relation to Vascular Function in a Bi-ethnic Cohort: the SABPA Study
WEDP085 Amber van Broekhoven
Short-term Lipopolysaccharide induces aortic valve thickening and valve hemorrhage in ApoE*3Leiden mice.
WEDP086 Hala Bagabir EFFECTS OF FAR INFRARED IRRADIATION ON VASCULAR FUNCTION IN HEALTHY SUBJECTS
WEDP087 Rio Juni Cardiac microvascular endothelial cells improve cardiomyocyte contractile function: The role of pro-inflammatory stimulation and Empagliflozin treatment
46 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
WEDP088 Pedro Felipe Malacarne
Cytochrome P450 reductase is important for endothelial function
WEDP089 Jerome Fourre Endothelial Cells Exert Stimulus-Specific Paracrine Effects on Co-Cultured Cardiomyocytes During Inflammation
WEDP090 Bernard van den Berg
Glomerular function and structural integrity depend upon endothelial hyaluronan synthesis
WEDP091 Aleksandra Kopacz S-nitrosylation-dependent protein aggregation in senescencent Nrf2-deficient endothelial cells: is there a role for ATM kinase?
WEDP092 Kwang Seok Kim A CXCR4 protects against brain vascular endothelial cells from radiation-induced senescence and damage
WEDP093 Stefano Tarantini Treatment of aged mice with the mitochondria targeted antioxidative peptide SS-31 protects against hypertension-induced cerebral microhemorrhages
WEDP094 Stefano Tarantini Endothelium-specific disruption of IGF-1 signaling impairs blood flow regulation in mice
WEDP095 Zoltan Ungvari Aging exacerbates obesity-induced cerebromicrovascular dysfunction in preclinical mouse models: novel targets for prevention of cognitive decline
WEDP096 Katrin Kalies Improving senescent endothelial cell function by partial reprogramming
WEDP097 Tamas Kiss Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
WEDP098 James Lane Docosahexaenoic Acid-derived D-Series Resolvins Direct the Regenerative Functions of Human Endothelial Colony Forming Cells
WEDP099 Michael HILL A Role for Mineralocorticoid Receptors in Vascular Smooth Muscle Cell Stiffness and Adhesion During Aging.
WEDP100 Francesca Bartoli-Leonard
SIRT1 deacetylation of p53 inhibits hyperglycaemic induced senescence in vascular smooth muscle cells
WEDP101 Ingrid Van Der Pluijm
Hybrid Optical and CT Imaging reveals increased matrix metalloprotease activity and apoptosis preceding cardiac failure in progeroid Ercc1 mice.
WEDP102 Pietro Maria Bertelli
Diabetes Induces Premature Senescence in Retinal Microvascular Endothelial Cells
WEDP103 Simin Berenji Ardestani
Endothelial function and cardiovascular stress markers in apoe knockout rats after a single simulated heliox dive
WEDP104 Sultan Al-Siyabi Prof. Sulayma Albarwani
Ageing Attenuates the Myogenic Tone of Large Coronary Arteries: Role of IP3R and L-Type Voltage-Gated Calcium Channels
WEDP105 Mieke Karel Formation of diverse occlusive arterial thrombi in a novel two-channel microfluidic system
47ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
WEDP088 Pedro Felipe Malacarne
Cytochrome P450 reductase is important for endothelial function
WEDP089 Jerome Fourre Endothelial Cells Exert Stimulus-Specific Paracrine Effects on Co-Cultured Cardiomyocytes During Inflammation
WEDP090 Bernard van den Berg
Glomerular function and structural integrity depend upon endothelial hyaluronan synthesis
WEDP091 Aleksandra Kopacz S-nitrosylation-dependent protein aggregation in senescencent Nrf2-deficient endothelial cells: is there a role for ATM kinase?
WEDP092 Kwang Seok Kim A CXCR4 protects against brain vascular endothelial cells from radiation-induced senescence and damage
WEDP093 Stefano Tarantini Treatment of aged mice with the mitochondria targeted antioxidative peptide SS-31 protects against hypertension-induced cerebral microhemorrhages
WEDP094 Stefano Tarantini Endothelium-specific disruption of IGF-1 signaling impairs blood flow regulation in mice
WEDP095 Zoltan Ungvari Aging exacerbates obesity-induced cerebromicrovascular dysfunction in preclinical mouse models: novel targets for prevention of cognitive decline
WEDP096 Katrin Kalies Improving senescent endothelial cell function by partial reprogramming
WEDP097 Tamas Kiss Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
WEDP098 James Lane Docosahexaenoic Acid-derived D-Series Resolvins Direct the Regenerative Functions of Human Endothelial Colony Forming Cells
WEDP099 Michael HILL A Role for Mineralocorticoid Receptors in Vascular Smooth Muscle Cell Stiffness and Adhesion During Aging.
WEDP100 Francesca Bartoli-Leonard
SIRT1 deacetylation of p53 inhibits hyperglycaemic induced senescence in vascular smooth muscle cells
WEDP101 Ingrid Van Der Pluijm
Hybrid Optical and CT Imaging reveals increased matrix metalloprotease activity and apoptosis preceding cardiac failure in progeroid Ercc1 mice.
WEDP102 Pietro Maria Bertelli
Diabetes Induces Premature Senescence in Retinal Microvascular Endothelial Cells
WEDP103 Simin Berenji Ardestani
Endothelial function and cardiovascular stress markers in apoe knockout rats after a single simulated heliox dive
WEDP104 Sultan Al-Siyabi Prof. Sulayma Albarwani
Ageing Attenuates the Myogenic Tone of Large Coronary Arteries: Role of IP3R and L-Type Voltage-Gated Calcium Channels
WEDP105 Mieke Karel Formation of diverse occlusive arterial thrombi in a novel two-channel microfluidic system
WEDP106 Eszter Farkas Cerebral Microvascular Impairment Contributes to Ischemic Injury in the Aging Brain
WEDP107 Diana Sá da Bandeira
PDGFRβ Is Required in Perivascular Cells to Generate Aortic Hematopoietic Stem Cells in Vivo
WEDP108 Luís Miguel Cardoso Dos Santos
Impact of circadian rhythm in smooth muscle cells
WEDP109 Luís Miguel Cardoso Dos Santos
Smooth-muscle cell switch in atherosclerosis: a matter of intracellular S100A4?
WEDP110 Erna-Zulaikha Dayang
Identification of Lipopolysaccharide-activated Endothelial Subpopulations with Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms
WEDP112 Mohamed Essameldin Abdelgawad
Single Cell Transcriptomic Heterogeneity of Novel Markers for Human Endothelial Progenitor Cells
WEDP113 Gosia Furmanik Endoplasmic Reticulum Stress in Vascular Smooth Muscle Cells Results in Contractile Phenotype Loss and Regulates Calcification Mediated by Grp78-Loaded Extracellular Vesicles
WEDP114 Antonija Sakic S100A4, a key player in plaque stabilization.
WEDP115 Carmen Ciavarella Endothelial-mesenchymal transition represents a key process during atherosclerotic plaque calcification
WEDP116 Matthew Lee Heterogeneity Enables Parallel Processing of Multiple Stimuli in the Intact Vascular Endothelium
48 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Industry Sponsored SymposiaTuesday April 16th 2019 from 13:00-14:00
Title: Microvascular High-tech solutions from bench to bed Physical vascular therapy
SPONSORED BY Bemer Int. AG Ralph Burger, Bemer, LIE (chair) & Joshua Berka, Bemer, USA (chair)
Session room : 0.4/0.5 Brussels/Paris
13:00 Fluorescence imaging procedure for lymphatic surgery, C. Täger (Germany)
13:15 Physical vascular therapy affects heart rate and heart rate asymmetry in patients with coronary heart disease, L. Hejjel (Hungary)
13:30 Observations and experiences in the application of a therapy blanket by induction of electromagnetic force on the tissue of horses, H.J. Genn (Germany)
13:45 Physical Vascular Therapy: Clinical Interventions and Preventative Medicine, J. Berka, NMD (USA)
Wednesday April 17th 2019 from 13:00-14:00
Title: Retinal Vessel Analysis – applied physiology and clinical application SPONSORED BY Imedos Systems GmbH Henner Hanssen Basel, CHE (chair) & Doreen Schmidl Vienna, AUT (chair)
Session room : 0.4/0.5 Brussels/Paris
13:00 Retinal Vessel Analysis: a biomarker of cardiovascular risk, Henner Hanssen (Basel, CH)
13:15 Retinal microvascular dysfunction in heart disease, Andreas Flammer (Zurich, CH)
13:30 Retinal vessel imaging: predictor for mortality in end stage renal disease – TheISAR study, Christoph Schmaderer (Munich, DE)
13:45 Microvascular dysfunction in obesity and diabetes: causes, consequences and actions, Boy Houben (Maastricht, NL)
Wednesday April 17th 2019 from 13:00-13:30
Title: Deoxyhemoglobin vasodilator
SPONSORED BY Circularity Healthcare
Session room : 2.1 Colorado
13:00 Efficacy of Transdermal CO2 Administration Using a Deoxyhemoglobin Vasodilator Medical Device to Treat Diabetic Foot Ulcers
Ito Puruhito (Airlangga University Medical Faculty, Indonesia)
49ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Our Sponsors/Exhibitors/Partners
Imedos Systems GmbH Booth L0.02
The microcirculation of the retina is an excellent window to the heart and the brain. Retinal vessels offer the unique opportunity to be examined in vivo and non-invasively and to provide valuable information about the condition of the body’s microcirculation.
Imedos is using these characteristics of the ocular transparency to analyse retinal arteries and veins. For more than 20 years we are committed to retinal microcirculation by developing and manufacturing systems to determine biomarkers of microvascular health.
Learn more about the possibilities of Imedos products and their scope for your microvascular research. Visit us at our booth at ESM&EVBO conference 2019 and join us at the Lunch Symposium “Retinal Vessel Analysis – applied physiology and clinical application” (Wednesday April 17th 2019 from 1-2 p.m.).
BEMER Int. AG Booth L0.01
The BEMER Int. AG was founded in 1998 and is an international company within the healthcare industry. The company based in Triesen / Liechtenstein is a medically-certified technology developer and inventor of the “BEMER® Physical Vascular Therapy”.
The core competence of the company is the research and development of high-tech solutions for the physical therapy of microcirculation disorders. The devices have been developed for daily use in the professional field as well as for private home users.
The BEMER Int. AG offers devices in the medical and veterinary fields.
Platinum Sponsors
The organizers of ESM-EVBO 2019 Maastricht greatly appreciate the kind support of all sponsors, exhibitors, and partners, in making this conference a great success!
50 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Imedos Systems GmbH | Am Nasstal 4 | 07751 JenaTel +49 (0) 36 41 63 96-0 | www.imedos.de
Technology for Microvascular Health Dynamic Vessel Analyzer DVA 3.0
…the third generation
to assess the
retinal microvascular
(dys-)function
51ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
20 Years leading Solutions for Microcirculation
Physical vascular therapy BEMER®
Microvascular High-tech solutions from bench to bed
Tuesday April 16, Room Brussels/Paris 1-2 p.m.
Sponsored Lunch Symposium BEMER
Visit us at Booth #L0.01 i.e. Level 0, Booth 1!
More Health. More Life.
www.bemergroup.com
52 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Exemplar Genetics Booth L1.00
Exemplar Genetics is the leading provider of genetically engineered MiniSwine research models of human disease. ExeGen® MiniSwine models allow researchers to study both safety and efficacy simultaneously with improved translational outcomes. The ExeGen® models assist in enabling discovery of human disease mechanisms, the optimization of novel diagnostics, and the development of new treatments by more accurately replicating human disease symptoms. Eighteen models are available today including cardiovascular, cancer, cystic fibrosis, renal, arrhythmia, neurodegenerative and other rare diseases. Exemplar Genetics additionally offers a custom model program and assists with the characterization of disease phenotype.
Sanofi
Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.
With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.
Sanofi, Empowering Life
Bronze Sponsors
FujiFilm VisualSonics Booth L1.02
ibidi – cells in focus Booth L1.01
Circularity Healthcare, LLC
Silver Sponsors
53ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Follow us on Twitter: @ExeGenMiniSwine
Phone: 001-712-722-2767Email: [email protected]
2018 Vascular Biology Ad.indd 1 2018-08-29 11:14:04 AM
Learn more at our booth!
Booth #L1.00
Booth #L1.02
54 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Discover the finest products for tissue blood flow and oxygen assessments
with global customer service to match
www.moor.co.uk
innovation in microvascular assessment
Booth L1.04
ibidi GmbH | +49 89 / 520 46 17 - 0 | [email protected] .com
Tube Formation Assays3 Reasons to Use the µ-Slide Angiogenesis
• Low Matrigel volume
• No meniscus
• High optical quality
Free samples at: ibidi.com
Booth L1.01
Booth L1.06
Booth L1.15
Booth L1.10Booth L1.05
Booth L1.07
55ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
The Tissue Viability Imager (TiVi) is polarization spectroscopy camera system that can see beyond the top layer of the skin and collect
information about the underlying microcirculation and other skin parameters. TiVi700 is the most sophisticated version of the TiVi
technology designed for demanding research applications. TiVi8000 is a simplified hand-held model intended for rapid screening of skin irritation and damage both in the laboratory
and at the worksite. TiVi9000 displays and objectively quantifies real time dynamic alterations in oral mucosa
microcirculation.
Automated FMD Robotic arm Operator independent
www.alf-distribution.com
A source of current research, new methods and state-of-the-art reviews in vascular biology and microcirculation
The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation.
Editor-in-Chief
U. Pohl Munich
www.karger.com/jvr KI19
143
Booth L1.12Booth L1.13
Stone SponsorsGreiner Bio-One B.V.IOP PublishingKK TechnologyLEA Medizintechnik GmbHLonzaMIMETASMoor Instruments
PetroTechPerimed ABtubu-bioUNEX CorporationVascular BiologyWheelsbridge AB
58 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
Level 0Booth L0.01 Bemer Int. AGBooth L0.02 Imedos Systems GmbH
Level 1Booth L1.00 Exemplar GeneticsBooth L1.01 ibidi – cells in focusBooth L1.02 FujiFilm VisualSonicsBooth L1.03 tebu-bioBooth L1.04 Vascular BiologyBooth L1.05 Moor InstrumentsBooth L1.06 KK Technology
Level 1 Booth L1.07 PeproTech Booth L1.08 Perimed ABBooth L1.09 IOP PublishingBooth L1.10 MIMETASBooth L1.11 LEA Medizintechnik GmbHBooth L1.12 WheelsBridge AB.Booth L1.13 UNEX Corporation Booth L1.14 Lonza Booth L1.15 Greiner Bio-One B.V.
Exhibitor Floor plan and Legend
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59ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS
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Thank You to our Sponsors/ Exhibitors and Partners
PLATINUM
innovation in microvascular assessment
SILVER
BRONZE
EXHIBITORS
PARTNERS European Society for Microcirculation (ESM)
European Vascular Biology Organization (EVBO)Cardiovascular Research (CVR)
Amsterdam Cardiovascular Sciences (VUmc)Dutch Society for Microcirculation
Dutch heart foundation / Hartstichting
University of Limburg (SWOL)CARIM (Universiteit Maastricht)
Gesellschaft für Mikrozirkulation und Vaskuläre BiologieJVR Journal of Vascular Research
ESC Working Group Atherosclerosis & Vascular BiologyServier