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PROGRAMME

2 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Table of Contents

Words of Welcome 3

Committees 4

Practical Information 5

Contact Us 10

Scientific Program Associated Meetings (by invitation only) 11

Program at a Glance 12

ECS Workshops 15

Detailed Program 17

Awards 30

Social Events 32

Posters 35

Industry Sponsored Symposia 48

Our Sponsors/Exhibitors 49

Partners 56

Notes 57

Exhibitor Floor plan and Legend 58

Thank You to our Sponsors/ Exhibitors and Partners 60

3ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Words of WelcomeWe are happy and proud to welcome you to the third European Microcirculation and Vascular Biology conference in Maastricht. Already being the third joint conference of ESM and EVBO, this promises to be a unique, successful, and inspiring series of meetings in the (cardio)vascular field.

Improving vascular health is an important goal to pursue, as cardiovascular diseases account for almost half of all deaths in Europe. Disturbances in normal (micro)vascular biology are at the basis of many diseases. From classical cardiovascular diseases, like myocardial infarction and stroke, to cardio-metabolic diseases, like diabetes and hypertension with related complications such as dementia, cognitive decline, heart failure, and chronic kidney disease. Of course, cancer and post-surgical tissue regeneration and wound healing clearly have an important vascular component. This broad range of diseases undoubtedly underlines the need to expand our knowledge on the basic mechanisms underlying the disturbances in normal (micro)vascular biology. With this conference we aim to address many aspects of these mechanisms through state-of-the-art symposia and workshops.

One of our aims is to stimulate and educate early career scientists (ECS). Besides a Young Investigator Symposium and many travel and poster awards, we composed a special program for our young delegates, including many workshops, their own social program, and preferred accommodation to stimulate new networks.

Maastricht is known for its 1992 Treaty to further European integration and the creation of one European currency, the euro. But Maastricht is also known as one of the oldest and certainly most beautiful cities of the Netherlands. It is positioned close to Belgium and Germany, and over 50% of the University’s students are foreign, giving the city an international style. This, together with the warm and hospitable atmosphere of Maastricht will ensure an exciting and fruitful stay.

On behalf of the national organizers: Jaap van Buul, Ed Eringa, Stephan Huveneers, and Guido Krenning.

Judith Sluimer Boy Houben Meeting chair Meeting Chair

4 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

CommitteesLocal Organizing Committee

Dr. Judith Sluimer (CARIM/MUMC+, Maastricht)Dr. Boy Houben (CARIM/MUMC+, Maastricht)Margaux Fontaine (CARIM/MUMC+, Maastricht)Tate Chimhanda (CARIM/MUMC+, Maastricht) Dutch Organizing Committee

Dr. Judith Sluimer (CARIM/MUMC+, Maastricht)Dr. Boy Houben (CARIM/MUMC+, Maastricht)Prof. Dr. Jaap van Buul (Sanquin, Amsterdam)Dr. Ed Eringa (VUMC, Amsterdam)Dr. Stephan Huveneers (AMC, Amsterdam)Dr. Guido Krenning (UMCG, Groningen) Young Investigator Symposium

Prof. Dr. Y. Alexander (United Kingdom)Dr. R. Boon (the Netherlands)Prof. Dr. M. Graupera (Spain) Core Scientific Committee

Prof. Dr. A. Koller (Hungary)Prof. Dr. Y. Alexander (United Kingdom)Prof. Dr. H. Morawietz (Germany)Dr. B. Bussolati (Italy)Dr. B. Houben (the Netherlands)Dr. J. Sluimer (the Netherlands)

International Scientific Committee

Prof. Dr. Y. Alexander (United Kingdom)Prof. Dr. A. Baker (United Kingdom)Prof. Dr. E. van Bavel (the Netherlands)Dr. R. Benedito (Spain)Prof. Dr. C. Betsholz (Sweden)Prof. Dr. N. Brown (United Kingdom)Dr. B. Bussolati (Italy)Prof. Dr. J.Y. Han (China)Prof. Dr. P. Hordijk (the Netherlands)

Prof. Dr. B. Imhof (Switzerland)Prof. Dr. F. Kiefer (Germany)Prof. Dr. A. Koller (Hungary)Prof. Dr. H. Morawietz (Germany)Dr. G. Pages (France)Prof. Dr. J. Pearson (United Kingdom)Prof. Dr. R. Siow (United Kingdom)Prof. Dr. C. Stehouwer (the Netherlands)Prof. Dr. D. Vestweber (Germany)

5ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Practical InformationVenue

The conference will take place in the Maastricht Exhibition & Congress Centre (MECC) in Maastricht (address: Forum 100). The congress centre consists of three multi-functional floors which can all be reached from the registration area. All meetings, plenary and parallel sessions are organized in the congress centre. Some early career scientist workshops and Monday morning sessions are organized in Maastricht University (entrance: Universiteitssingel 40, 5min from MECC).

Accessibility

Please come to the conference help desk, located in the entrance, Level 1 / Trajectum of MECC conference centre, if you need any information or support. Meeting rooms are located on Level 0 / Lobby and Level 2 / Promenade. (Please be aware of different Conference Secretariat opening hours).

Language

The official language of the conference is English.

Accommodation

Please come to the registration desk for any hotel booking changes.

Download Google maps for off-line use to orient yourself with GPS

Venues:• MECC Conference Centre Maastricht : Forum 100, 6229 GV Maastricht• Maastricht University Medical Centre : P. Debyelaan 25, 6229 HX, Maastricht

Social Events:• Welcome Reception Town Hall : Markt 78, 6211 CL Maastricht• Conference Party : Rebelle Maastricht, Kesselskade 43, 6211 EN Maastricht• Early Career Scientist BBQ and Party : Stayokay Hostel, Maasboulevard 101,

6211 JW Maastricht

Coffee Bar Nearby:• Bakery Cafe : Joseph Bechlaan 100, 6229 GR Maastricht• University Sports Centre Caffee/Lunch Bar RIVAZZA, P. Debyeplein 15,

6229 HA Maastricht

Hotels Nearby:• Hotel Apart Randwijk : Endepolsdomein 30, 6229 EM Maastricht• Hotel NH Maastricht : Forum 110, 6229 GV Maastricht

6 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Banking Facilities

An ATM machine is located at the main entrance / Level 1 of MECC Maastricht.

Certificate of Attendance

Participants who are entitled to receive a Certificate of Attendance will receive an email from the Registration Department after the conference.

CME Accreditation

ESM-EVBO 2019 has been granted 16 European CME credits (ECMEC®s), which equates to a maximum of 16 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spends in the educational activity.

Delegates who would like to collect CME credits should make sure their badge is scanned before entering a session room to determine the number of hours to be credited. Please approach the staff member at the entrance to each session room to have your badge scanned. You will also be asked to complete a feedback form and a certificate will be provided after the conference when your attendance has been confirmed.

Cloakroom

There is a guarded cloakroom on arrival on Monday and departure on Thursday on Level 1.

There is no guarded cloakroom on Tuesday and Wednesday. There are coat racks on Level 1 / Entrance Level.

Coffee and Lunch Breaks and Poster Session Nutrition

Catering during breaks is served in the exhibition area on Level 0 and Level 1. The exhibition is located on Level 0 and Level 1. Lunch Boxes are available on Tuesday and Wednesday. A special catering station for delegates with dietary requirements is available on Level 0.

Lunch Options on Monday and Thursday:

There is a restaurant in the MECC Centre located on Level 0 (just around the corner from the Conference Help Desk) and the Hotel NH next to the MECC has an a-la-carte restaurant on the ground floor.

There are two coffee bars in 5 min walking distance. Bakery Cafe (Joseph Bechlaan 100) and RIVAZZA Caffee/Lunch Bar in the UM Sports Building (P. Debyeplein 15).

7ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Conference Badges

All participants, accompanying persons and exhibitors must wear the identification badges. Entrance to meeting halls, Exhibition area, catering stations and to all social events will not be permitted to any person without a badge.

Conference Mobile App

Please use the download link provided in your information email “ESM-EVBO 2019 useful information for your travel to Maastricht” to download the Conference Mobile App.

Conference Programme

The detailed conference programme is available online (www.esm-evbo2019.org) and also via the ESM-EVOB 2019 Mobile App.

Opening Hours Conference Registration Help Desk*Monday 15 April , 2019 11:00 – 16:30 10:00 – 18:00Tuesday 16 April, 2019 10:30 – 13:00 and 15:30 – 18:00 07:30 – 20:00Wednesday 17 April, 2019 10:30 – 13:00 and 15:30 – 18:00 07:30 – 19:00Thursday 18 April, 2019 10:00 – 11:00 08:00 – 13:00

*See page 8 for information about the Help Desk.

8 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Help Desk The Help Desk is able to help you for general information. During Conference Secretariat opening hours, you are able to register on-site, change your badge, pay an outstanding registration amount, change your hotel and buy Conference Party or Student Party tickets.

City Map Maastricht

You will find your city map in your conference bag.

Exhibition Exhibition opening hours

The exhibition is located on Level 1 (Lobby) Monday, 15 April 13:00 – 17:30and Level 1 (Entrance/ Trajectum) next to Tuesday, 16 April 09:30 – 19:00the Poster boards and catering stations Wednesday, 17 April 09:30 – 19:00for coffee breaks and lunch boxes. Thursday, 18 April 09:30 – 12:00

First Aid

For any emergencies please note the Maastricht Hospital is located just across from the MECC Conference Centre. Please visit the conference help desk for assistance. National emergency phone number is 112.

Information Desk Please come to the conference help desk. City information and restaurant guides are available.

Liability and Insurance The organizers cannot accept liability for personal accidents or loss of or damage to private property of participants. Participants are advised to take out their own personal travel and health insurance for their trip.

Lost and Found The conference help desk will collect all lost and found objects.

Parking MECC Maastricht has several different car parking areas which are within walking distance of the entrance. Parking at MECC Maastricht is free for the first half hour. After 30 minutes you pay € 3 per full hour, with a maximum of € 15 per 24 hours.

Posters Posters can be found on Level 0 and Level 1. Posters are mounted for 1 1/2 days. Posters change Tuesday evening after 18:30. Please check the poster plan in the pocket programme to find the location and day of your poster(s).

Poster presenters: please check poster guidelines for instructions. For questions and poster mounting material please contact the conference help desk. Poster sessions are Tuesday and Wednesday from 17:00 – 18:30.

9ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Registration Please come to the Conference Help Desk, located on Level 1/ / Entrance of the MECC Conference Centre for your pre-registered badge pick-up and on-site registration, as well as if you need any information or support. Please note different opening hours for the Conference Secretariat/Registration Services.

Your Registration includes :• Access to the conference centre and scientific sessions• Pocket program and conference bag• Welcome Reception (if registered)• Coffee Breaks• Poster Session Nutrition• 2 Lunch Boxes (not included with on-site registration)

Smoking Policy This will be a non-smoking event. Smoking is prohibited in all buildings and in all restaurants in Maastricht, providing limited designated smoking areas.

Safety and Security It is advisable that you do not leave bags or suitcases unattended at any time, whether inside or outside the session halls.

Social Events Several public buses (every 10 min.) and the train (4 times per hour) run to Maastricht central railway station or Markt (see details on page 33). The train also takes you from Maastricht Randwijck to Central. Download NS planner app for details.

Welcome Reception : Monday 15th April; 18:00 – 19:00 Town Hall Address: Maastricht Town Hall, Markt 78, 6211 CL Maastricht

Early Career Scientist BBQ and Party : Tuesday 16th April; start 19:00 open-ended Address: Stayokay Hotel, Maasboulevard 101, 6211 JW Maastricht

Conference Party Rebelle Maastricht : Wednesday 17th April ; start 19:30 open-ended Address: Rebelle Maastricht, Kesselskade 43, 6211 EN Maastricht Social Media Facebook - ESMEVBO 2019 Twitter -https://twitter.com/ESMEVBO2019/ @ESMEVBO2019/ # ESMEVBO2019

10 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Speaker Centre The Speaker Centre is located on Level 1 / Entrance Level behind the posters.

All presenters must check in at the Speaker Centre after their arrival and hand in their presentation at least 3 hrs before their scheduled session.

Speaker Centre Opening Hours :

Monday 15 April , 2019 10:00 – 17:00

Tuesday 16 April, 2019 07:30 – 17:00

Wednesday 17 April, 2019 07:30 – 17:00

Thursday 18 April, 2019 07:30 – 11:00

Wi-Fi

The MECC wi-fi is available free of charge for delegates in the conference centre. Network : MECC Free WiFi (no Username and no Password required, you only have to accept the terms and conditions). Please note : idle time is 60 minutes (which means you need to login again after 60 min). *Please bear with us if you have trouble connecting to the wifi, as this may be due to the volume of people and number of devices being used at the same time.

Toilets Main toilets are located on Level 0

Contact UsA111 Power of Conference Service is a Canada and Switzerland based professional conference organiser. Please contact us for any questions regarding the conference, registration, sponsorship, as well as for hotel reservations and hotel changes.

ESM-EVBO 2019 Registration <[email protected]>Tel + 31-6-47002024 Within The Netherlands dial 06-47002024

A111 Power of Conference ServiceKäsereistrasse 3, 4206 Seewen-Basel, Switzerland300-422 Richards Street, Vancouver BC, V6B 2Z4, CanadaEmail: [email protected]

11ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Contact Us

Scientific Program Associated Meetings (by invitation only)Monday 15 April 2019 10:00 – 11:30 Room : 0.4/0.5 Brussels/ParisBoard Meeting ESM European Society for Microcirculation

10:00 – 11:30 Room : Office 1.3Board Meeting EVBOEuropean Vascular Biology Organization

Tuesday 16 April 2019

18:30 – 19:30 Room : 2.1 ColoradoGeneral Assembly ESM European Society for Microcirculation

18:30 – 19:30 Room : 0.4/0.5 Brussels/ParisGeneral Assembly EVBOEuropean Vascular Biology Organization

12 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Program at a Glance

Day 1 – Monday April 15

MUMC

9:00-12:00 ECS Workshops

MECC10:00-11:30 Board meeting ESM

10:00-11:30 Board meeting EVBO

Registration opens 10:00

Arrival+registration

12:30 – 13:15

Welcome and openingJudith Sluimer

Boy HoubenRianne Letschert

13:15 – 14:00

Session 1.1

EVBO Medal lectureElisabetta Dejana

14:00 – 15:45Session 1.2

Young Investigator session

15:45 – 16:15 Coffee break / Exhibition

16:15 – 17:00

Session 1.3

Coen Stehouwer Microvascular function and cardiometabolic diseases

17:00 – 18:00 Make your way to City Hall

18:00 – 19:00 Welcome reception City Hall

13ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Day 2 – Tuesday April 16

MECC7:45– 8:25 Different Morning ECS workshops

8:30 – 9:10

Session 2.1

DHF lecture: Dietmar VestweberRegulation of endothelial junctions during leukocyte extravasation

09:15 – 10:30

Session 2.2 Session 2.3 Session 2.4

Lymphatic vessels in development and disease

Cerebral circulation, from arterioles to arteries from

animals to human

Intra-arterial treatment in Acute Ischemic Stroke:

how to clean up the microcirculation?

10:30 – 11:00 Coffee break / Exhibition

11:00 – 12:30

Session 2.5 Session 2.6 Session 2.7

Endothelial cell adhesion Vascular ageing and senescence

The ‘other’ cerebral circulation: paravascular channels and lymphatics

(DHF lecture)

12:30 – 13:-00 Lunch break / Exhibition

13:00 – 14:00

Lunch Session 2A Lunch Session 2B

Sponsored industry symposia Microvascular High-tech

solutions from bench to bed Physical vascular therapy

Pathomechanisms microcirculation in CVD

12:45 – 13:30ECS workshop

14:15 – 15:45

Session 2.8 Session 2.9 Session 2.10

Angiogenesis in regeneration and disease

ESC WG symposium: EC dysfunction

CVR symposium: Non-coding RNA in pathological

vascular remodelling

15:45 – 16:15 Coffee break / Exhibition

Session 2.11

16:15 – 17:00 Christoph Scheiermann: Circadian rhythms in leukocyte-endothelial cell interactions

17:00 – 18:30 Poster sessions. Exhibition and drinks

18:30 – 19:30 General assemblies ESM members

18:30 – 19:30 General assemblies EVBO members

19:00 – 22:00 Student party

14 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Day 3 – Wednesday April 17

MECC8:00 – 8:40 Different Morning workshops ECS

8:00 - 8:45Session 3.0

Launch of the ESM working group on Retinal Microvascular Research

8:45 – 9:25

Session 3.1

Christer Betsholtz Vascular heterogeneity

09:30 – 10:30

Session 3.2 Session 3.3

Vascular cell heterogeneity CVR-session: Oxidative stress and Infl ammation

10:30 – 11:00 Coffee break / Exhibition

11:00 – 12:30

Session 3.4 Session 3.5

Vascular cell plasticity and clonality Clinical microvascular dysfunction in cardiometabolic diseases

12:30 – 13:-00 Lunch break / Exhibition

13:00 – 14:00Lunch Session 3A 13:00 – 14:00 Lunch Session 3B 13:00 – 13:30

Sponsored Industry SymposiaRetinal Vessel Analysis

Sponsored Industry SymposiaDeoxyhemoglobin Vasodilator

14:15 – 15:45

Session 3.6 Session 3.7

Vascular Pathophysiology, diagnostics, and treatment Resistance arteries

15:45 – 16:15 Coffee break / Exhibition

16:15 – 17:00Session 3.8

Dave Newby Clinical imaging of vascular disease

17:00 – 18:30 Poster sessions, exhibition and drinks

18:30 – 19:30 Make your way to the Conference Party

19:30 – open ended Conference party

15ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Day 4 – Thursday April 18

8:30 – 9:10

Session 4.1

EVBO lecture: Rui Miguel Benedito

Using multispectral genetic mosaics to enlighten endothelia heterogeneity during angiogenesis

09:30 – 10:30

Session 4.2 Session 4.3

Endothelial metabolism and mitochondrial function in angiogenesis Vascular drug targeting

10:30 – 11:00 Coffee break / Exhibition

Session 4.4

11:00 – 11:45 ESM Malpighi Award Lecture: Akos Koller: Going with the fl ow in microcirculation

11:45 – 12:15 JVR / ESM Award lecture: Lydia Sorokin: The role of endothelial laminins in vascular function

12:15 – 12:30 Travel and Poster Awards and closing

12:30 Departure

ECS Workshops Monday, April 15, 2019 Plenary Sessions 09:00 – 12:30 Early Career Scientists Workshops

Maastricht University or MECC ECS Workshops I / Pre-registration required

10:30 – 12:00 Mass spectometry imaging Meet 10:20 Maastricht University, Universiteitssingel 50, room 5.467 Host: Benjamin Balluff, Maastricht, Netherlands

9:00 – 12:00 Non-invasive imaging Meet 8:50 Maastricht University hospital, P. debyelaan 25, Greepzaal level 4 Host: Eline Kooi. Maastricht, Netherlands 9:00 – 12:00 Press communication and Maximize impact from your research Meet 9:50 Maastricht University, Oxfordlaan 70, ground floor meeting room Host: Henri Theunissen, Maastricht, Netherlands and Nieky van Steenkiste, Maastricht, Netherlands

(Early Career Scientists)

16 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Tuesday, April 16, 2019 7:45 – 8:25 Early Career Scientists Workshops II

Pre-registration required

7:45 – 8:25 0.2/0.3 Copenhagen /Berlin (MECC) Meet 07:40 Meet the professor

Andrew Baker, Edinburgh University, United Kingdom

7:45 – 8:25 2.1 Colorado (MECC) Meet 07:40 Meet the professor Jaap van Buul. Sanquin Amsterdam, The Netherlands

7:45 – 8:25 1.3 office (MECC) Meet 07:40 Meet the professor

Yvonne Alexander, Manchester Metropolitan University, United Kingdom

7:45 – 8:25 1.2 office (MECC) Meet 07:40 Meet the professor

Mariona Graupera. IBIDELL, Barcelona, Spain

12:45 – 13:30 Early Career Scientists Workshop II Lunch S.2C Pre-registration required 0.2/0.3 Copenhagen /Berlin (MECC) Cardiovascular pathophysiology of old

age hypertension: the virtual patient speaks (bring your own laptop, pre-installed CircAdapt tool). Koen Reesink, Maastricht University, The Netherlands

Wednesday, April 17, 20197:45 – 8:25 MECC – Early Career Scientists Workshop III

Pre-registration required

7:45 – 8:25 1.3 office (MECC) Meet the professor Rafael Kramann, RWTH Aachen University, Germany 7:45 – 8:25 1.2 office (MECC) Meet the professor Rhian Touyz, University of Glasgow, United Kingdom 12:45 – 14:00 Maastricht University – Early Career Scientists Workshop III Pre-registration required Maastricht University hospital, Verheylaan 5.m1.031 Talk to the editor of cardiovascular research Tom Guzik, Glasgow University, United Kingdom

17ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Detailed Program Monday, April 15, 2019

Monday, A

pril 15, 201912:30 – 13:15 PLENARY ROOM 0.4/0.5 Brussels/Paris – Session 1.0. – Welcome and opening

12:30 – 12:45 S.1.0.1 Welcome and opening words Boy Houben, Maastricht University, The Netherlands Judith Sluimer, Maastricht University, The Netherlands 12:50 – 13:05 S.1.0.3 Official Opening of the Conference: Towards a more balanced system of

rewarding academics Rianne Letschert, Rector of Maastricht University, The Netherlands

13:15 – 14:00 PLENARY ROOM 0.4/0.5 Brussels/Paris – Session 1.1. – EVBO Medal lecture Yvonne Alexander, Manchester Metropolitan University, United Kingdom (chair) Benedetta Bussolati, University of Turin, Italy (chair) 13:15 – 14:00 Transcriptional regulation of the Blood Brain Barrier Elisabetta Dejana, University of Milan, Italy 14:00 – 15:45 PLENARY SPEAKERS 0.4/0.5 Brussels/Paris Session 1.2. Young Investigator session Yvonne Alexander, Manchester Metropolitan University, United Kingdom (chair)

Mariona Graupera, Institut d’Investigació Biomèdica de Bellvitage, Spain (chair) 14:05 – 14:25 S.1.2.1 Metabolic interactions between the endothelium and the muscle

microenvironment Katrien de Bock, ETH, Zürich, Switzerland 14:25 – 14:45 S.1.2.2 Telomerase as therapeutic agent for cardio protection Christian Bär, Hannover Medical School, Germany 14:45 – 15:05 S.1.2.3 Angiocrine signals in ageing and disease Anjali Kusumbe, University of Oxford, United Kingdom 15:05 – 15:25 S.1.2.4 Dissecting the roles of altered cell type composition and cell specific

responses to proatherogenic stimuli in contributing to global gene expression changes in atherosclerotic aorta Minna Kaikkonen-Määttä, University of Eastern Finland, Finland

15:25 – 15:45 S.1.2.5 Endothelial Cell Orienteering Claudio Franco, Universidade de Lisboa, Portugal 15:45 – 16:15 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 16:15 – 17:00 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 1.3.

Microvascular function and cardiometabolic diseases Boy Houben, Maastricht University, The Netherlands (chair)

Ed Eringa, Free University Amsterdam, The Netherlands (chair) 16:15 – 17:00 Microvascular function and cardiometabolic diseases

Keynote: Coen Stehouwer, Maastricht University, The Netherlands 18:00 – 19:00 Welcome Reception City Hall Maastricht

18 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

9:15 – 10:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 2.2 Lymphatic vessels in development and disease Ferdinand Le Noble, Karlsruhe Institue of Technology KIT, Germany (chair) Lena Claesson-Welsh, Uppsala University, Sweden (chair)

9:15 – 9:50 S.2.2.1 Vascular bed-specific mechanisms of lymphatic development and disease Taija Makinen, Uppsala University, Sweden

9:50 – 10:05 S.2.2.2 Uparap/endo180 receptor, a gatekeeper of lymphatic branching and

organization during pathological lymphangiogenesis Florent Morfoisse, University of Liege, Belgium 10:05 – 10:20 S.2.2.3 Regulation of Cardiac Lymphatic Development by Tbx1

Elizabeth Illingworth, University of Salerno, Italy 10:20 – 10:35 S.2.2.4 Bradykinin Signaling Regulates Solutes Permeability and Cellular

Junctions Organization in Lymphatic Endothelial Cells Sybille Kempe, Unikersitätsklinik Ulm, Germany

9:15 – 10:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 2.3 Cerebral circulation, from arterioles to arteries from animals to

human Akos Koller, University of Physical Education, Budapest, Hungary (chair) Peter Toth, University of Pecs, Hungary (chair)

9:15 – 9:35 S.2.3.1 Role of synergism between pressure and flow activated cerebrovascular mechanisms and mechanotransduction signaling in the autoregulation of cerebral blood flow Akos Koller, University Of Physical Education, Hungary

9:35 – 9:55 S.2.3.2 Integrated Assessment of Cerebral Blood Flow Regulation in Humans:

Dynamic Cerebral Autoregulation, CO2 Reactivity and Neurovascular Coupling Ronney Panerai, University Of Leicester, United Kingdom

9:55 – 10:15 S.2.3.3 Traumatic brain injury-induced cerebrovascular alterations

Peter Toth, University Of Pecs, Hungary 10:15 – 10:35 S.2.3.4 The effects of Vaccinium Myrtillus Extract on Hamster Pial

Microcirculation during Hypoperfusion-Reperfusion Injury Antonio Colantuoni, Federico II University Medical School-Naples, Italy

Tuesday, April 16, 2019 8:30 – 9:10 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 2.1

Dutch Heart Foundation lecture Jaap van Buul, Sanquin and University of Amsterdam, The Netherlands (chair) Stephan Huveneers, University of Amsterdam, The Netherlands (chair)

8:30 – 9:10 Regulation of endothelial junctions during leukocyte extravasation Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Münster, Germany

9:10 – 9:15 Break

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19ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

9:15 – 10:30 CONCURRENT SESSION ROOM 0.2/0.3 Copenhagen /Berlin Session 2.4 Intra-arterial treatment in Acute Ischemic Stroke: how to clean up the

microcirculation? Ed van Bavel, University of Amsterdam, The Netherlands (chair) Stephen Payne University of Oxford, UK (chair)

9:15 – 9:35 S.2.4.1 Microvascular events in acute ischemic stroke Ed van Bavel, University of Amsterdam, The Netherlands 9:35 – 9:55 S.2.4.2 Coupled multi-scale models of the microcirculation in the cerebral cortex Stephen Payne, University of Oxford, United Kingdom 9:55 – 10:15 S.2.4.3 the VWF/ADAMTS13 axis in cerebral ischemia/reperfusion injury Simon de Meyer, KU Leuven, Belgium 10:15 – 10:30 S.2.4.4 Unravelling the (sub)cellular mechanisms of low frequency

electromagnetic stimulation as ischemic stroke therapy Hannelore Kemps, Hasselt University, Belgium

10:30 – 11:00 Coffee Break and Exhibition (Exhibition Area Level 0 and 1)

11:00 – 12:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 2.5 Endothelial cell adhesion Stephan Huveneers, University of Amsterdam, The Netherlands (chair) Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Münster, Germany (chair)

11:00 – 11:30 S.2.5.1 Leukocyte transendothelial migration: the endothelium in control Jaap van Buul, Sanquin and University of Amsterdam, The Netherlands

11:30 – 11:45 S.2.5.2 ROCKs play a major role in the control of gene expression program by the CCM

complex Daphné Vannier, Institute For Advanced Biosciences Cnrs/inserm, France 11:45 – 12:00 S.2.5.3 High-level Nrf2 Activation Promotes Endothelial Detachment– Implications for

Acute Coronary Syndromes Triggered by Endothelial Erosion of Plaques Alex Langford-Smith, Manchester Metropolitan University, United Kingdom 12:00 – 12:15 S.2.5.4 Mitochondrial metabolism limits ECM formation in human iPSC-derived

endothelium Gesa Tiemeier, Leiden UMC, The Netherlands 12:15 – 12:30 S.2.5.5 Bosutinib Protects against Vascular Leakage by Improving Endothelial Cell-

Matrix Adhesion Liza Botros, University of Amsterdam, The Netherlands

Tuesday, A

pril 16, 2019

20 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

11:00 – 12:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 2.6 Vascular ageing and senescence Guido Krenning, University of Groningen, The Netherlands (chair) Guido de Meyer, University of Antwerp, Belgium (chair)

11:00 – 11:30 S.2.6.1 Vascular cell ageing and senescence Martin Bennett, University of Cambridge, United Kingdom 11:30 – 11:45 S.2.6.2 Aging downregulates lamin A/C expression in smooth muscle cells: A

potential mechanism contributing to age-dependent cardiac disease Alberto Del Monte Monge, Centro Nacional De Investigaciones Cardiovasculares,

Spain 11:45 – 12:00 S.2.6.3 Resistance Vasculature in Chronic Kidney Disease: focus on function,

structure and senescence signature Samsul Arefin, Karolinska Institutet, Sweden

12:00 – 12:15 S.2.6.4 Translational approaches to understanding aging-induced

cerebromicrovascular dysfunction Andriy Yabluchanskiy, University Of Oklahoma Health Sciences Center, USA 12:15 – 12:30 S.2.6.5 Keap-1-dependent interplay between S-nitrosylation and protein

aggregation in ageing endothelium Aleksandra Kopacz, Jagiellonian University, Poland

11:00 – 12:30 CONCURRENT SESSION ROOM 0.2/0.3 Copenhagen /Berlin Session 2.7 The ‘other’ cerebral circulation: paravascular channels and

lymphatics Erik Bakker University of Amsterdam, The Netherlands (chair) Steven Proulx ETH, Zürich, Switzerland (chair)

11:00 – 11:20 S.2.7.1 Dutch Heart Foundation lecture: Manipulating Meningeal lymphatic vessels in Development and Disease

Salli Antila, University of Helsinki, Finland 11:20 – 11:40 S.2.7.2 In vivo imaging of the outflow of cerebrospinal fluid through lymphatic

vessels in mice Steven Proulx, ETH, Zürich, Switzerland 11:40 – 12:00 S.2.7.3 Fluid flow in the brain, role of paravascular spaces and hypertension Erik Bakker, University of Amsterdam, The Netherlands 12:00 – 12:15 S.2.7.4 Re-evaluation of CSF outflow in mice using non-invasive MRI dynamic

contrast-enhanced imaging Yann Decker, University Of The Saarland, Germany 12:15 – 12:30 S.2.7.5 Lymph Flow Mediated Postnatal Remodeling of Meningeal Lymphatics is

Required for the Uptake and Transport of Macromolecules from the Central Laszlo Balint, Semmelweis University Budapest, Hungary 12:30 – 13:00 Lunch Break and Exhibition (Exhibition Area Level 0 and 1)

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13:00 – 14:00 PLENARY ROOM 0.4/0.5 Brussels/Paris Details see page 48 Lunch S.2A Industry Sponsored Lunch Symposia: Microvascular High-tech

solutions from bench to bed Physical vascular therapy Ralph Burger, Bemer Int. AG, Germany (chair)

Joshua Berka, Infinity Health Source, USA (chair)

13:00 – 13:15 Lunch S.2A.1 Fluorescence imaging procedure for lymphatic surgery Christian Taeger, University Hospital of Regensburg, Germany 13:15 – 13:30 Lunch S.2A.2 Physical vascular therapy affects heart rate and heart rate

asymmetry in patients with coronary heart disease Laszlo Hejjel, University of Pecs, Hungary

13:30 – 13:45 Lunch S.2A.3 Observations and experiences in the application of a therapy

blanket by induction of electromagnetic force on the tissue of horses Hermann Josef Genn, Horse Clinic Mühlen, Germany

13:45 – 14:00 Lunch S.2A.4 Physical Vascular Therapy: Clinical Interventions and

Preventative Medicine Joshua Berka, Infinity Health Source, USA 13:00 – 14:00 2.1 Colorado Lunch S.2B Pathomechanisms microcirculation in CVD Akos Koller, University of Physical Education, Budapest, Hungary (chair) Ines DrenjanČević, University of Osijek, Croatia (chair)

13:00 – 13:15 Lunch S.2B.1 Vascular Cognitive Impairment in experimental hypertension: the microglial culprit Danielle Kerkhofs, Maastricht University, The Netherlands

13:15 – 13:30 Lunch S.2B.2 Increased oxidative stress underlies impaired endothelial

function and vascular reactivity with high salt dietary intake, independently of blood pressure changes – translational studies

Ines DrenjanČević, University of Osijek, Croatia 13:30 – 13:45 Lunch S.2B.3 Treatment with a NAD+ Booster Rescues Cerebromicrovascular

Function in Aged Mice Zoltan Ungvari, University of Oklahoma HSC, USA 13:45 – 14:00 Lunch S.2B.4 Aprotinin preserves cremaster microcirculatory perfusion, but not

renal perfusion following cardiopulmonary bypass in rats Nicole A.M. Dekker, Free University of Amsterdam, The Netherlands 14:00 – 14:15 Break to change session rooms

22 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

14:15 – 15:45 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 2.8 Angiogenesis in regeneration and disease Massimo Santoro, University of Padova, Italy (chair) Marjo Donners, Maastricht University, The Netherlands (chair)

14:15 – 14:45 S.2.8.1 Regulation of spinal cord vascularization and regeneration Ferdinand Le Noble, Karlsruhe Institue of Technology KIT, Germany 14:45 – 15:15 S.2.8.2 Imaging hypoxia in living cells Friedemann Kiefer, Max Plank inst. for molecular Biomedicine Münster, Germany 15:15 – 15:30 S.2.8.3 The mitochondrial fission factor Dynamin Related Protein 1 limits VEGF/

VEGFR2 endocytic trafficking and angiogenesis. Stephanie Herkenne, Unipd/uld, Italy

15:30 – 15:45 S.2.8.4 Beyond Pericytes – PDGF-BB Accelerates Vascular Stabilization by

Stimulating the Semaphorin3A/Neuropilin1+ Monocyte Axis Andrea Banfi, Basel University Hospital, Switzerland 14:15 – 15:45 CONCURRENT SESSION ROOM 2.1 Colorado Session 2.9 ESC WG symposium: EC dysfunction Paul Evans, University of Sheffield, United Kingdom (chair) Marie-Luce Bochaton-Piallat, University of Geneva, Switzerland (chair)

14:15 – 14:30 S.2.9.1 Brachial and retinal endothelial dysfunction – methodology and effect of exercise

Arno Schmidt-Trucksäss, University of Basel, Switzerland 14:30 – 14:45 S.2.9.2 Epigenetic changes, oxidative stress and endothelial dysfunction in

diabetes Rosa Suades Soler, Karolinska Institutet, Sweden 14:45 – 15:00 S.2.9.3 Endothelial function and coronary microcirculation Danijela Trifunovic, University of Belgrade, Serbia 15:00 – 15:15 S.2.9.4 Flow-mediated dilation (FMD) and peripheral endothelial function

assessment Michael Shechter, Tel Aviv University, Israel

15:15 – 15:30 S.2.9.5 Metabolic control of vascular function: the role of gastrointestinal

hormones Elena Osto, University Hospital Zurich-institute Of Clinical Chemistry, Zürich,

Switzerland 15:30 – 15:45 S.2.9.6 Endothelial dysfunction in the diabetic patient and the contribution by

circulating endothelial colony forming cells. Yvonne Alexander, Manchester Metropolitan University, United Kingdom

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14:15 – 15:45 CONCURRENT SESSION ROOM 0.2/0.3 Copenhagen /Berlin Session 2.10 CVR symposium: Non-coding RNA in pathological vascular

remodelling Andrew Baker, University of Edinburgh, United Kingdom (chair) Lars Maegdefessel, Karolinska institute, Stockholm, Sweden (chair)

14:15 – 14:35 S.2.10.1 The regulation and function of non-coding RNAs in vascular disease development

Lars Maegdefessel, Karolinska institute, Stockholm, Sweden 14:35 – 14:55 S.2.10.2 Role of non-coding RNAs in atherosclerosis

Jason Johnson, University of Bristol, United Kingdom 14:55 – 15:15 S.2.10.3 Control of endothelial cell function by lncRNAs

Reinier Boon, Free University of Amsterdam, The Netherlands 15:15 – 15:30 S.2.10.4 Functional high-throughput screening identifies a role for microRNA-26b in

the pro-survival of endothelial cells and in vessel calcification. David Mellis, University Of Edinburgh, United Kingdom

15:30 – 15:45 S.2.10.5 Loss of the long non-coding RNA MIR503HG promotes

endothelial-to-mesenchymal transition Alena Shmakova, University Of Edinburgh, United Kingdom 15:45 – 16:15 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 16:15 – 17:00 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 2.11 Leukocyte traffic and vascular interactions Dietmar Vestweber, Max Planck Institute for Molecular Biomedicine, Münster, Germany (chair) Jaap van Buul, Sanquin and University of Amsterdam, The Netherlands (chair)

16:15 – 17:00 Circadian rhythms in leukocyte-endothelial cell interactions Keynote: Christoph Scheiermann, University Of Geneva, Switzerland

17:00 – 18:30 Poster sessions; exhibition, and drinks (Exhibition Area Level 0 and 1) 18:30 – 19:30 2.1 Colorado – General assembly ESM members 18:30 – 19:30 0.4/0.5 Brussels/Paris – General assembly EVBO members 19:00 – open Student Party – StayOK Hotel

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24 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Wednesday, April 17, 2019 8:00 – 8:45 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 3.0 Launch of ESM working group on Retinal Microvascualr Research Henner Hanssen, Basel, Switzerland (chair) Boy Houben, Maastricht, The Netherlands (chair) 8:00 – 8:10 Introduction and Launch Boy Houben, Maastricht University, The Netherlands

8:10 – 8:25 S 3.0.1 Presentation of the Working Group Henner Hanssen, University Basel, Switzerland 8:25 – 8:35 S 3.0.2 Promisses of angioOCT for retinal microvascular research

Tos Berendschot , Maastricht University, The Netherlands 8:35 – 8:45 S 3.0.3 Developments in Retinal Vessel Analysis

Henner Hanssen, University Basel, Switzerland 8:45 – 9:25 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 3.1 Vascular heterogeneity Rafael Kramann, RWTH Aachen University, Germany (chair) Judith Sluimer, Maastricht University, The Netherlands (chair)

8:45 – 9:25 Cellular interactions and heterogeneity in the blood microvasculature Keynote: Christer Betsholtz, Uppsala University, Sweden 9:25 – 9:30 Break

9:30 – 10:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 3.2 Vascular cell heterogeneity Christer Bestholtz, Uppsala University, Sweden (chair) Jason Kovacic, Icahn School of Medicine, New York, USA (chair)

9:30 – 10:00 S.3.2.1 Heterogeneity of perivascular cells in the kidney Rafael Kramann, RWTH Aachen University, Germany 10:00 – 10:15 S.3.2.2 Single cell sequencing reveals heterogeneity of adventitial mesenchymal

cells in healthy and diseased mice Kim Van Kuijk, Maastricht University, The Netherlands 10:15 – 10:30 S.3.2.3 Single cell transcriptomics identifies a Hedgehog-mediated

immunomodulatory signaling circuit between endothelial and perivascular stromal Ignacio Benedicto, Centro Nacional De Investigaciones Cardiovasculares (cnic), Spain

9:30 – 10:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 3.3 CVR-session: Oxidative stress and Inflammation Henning Morawietz, TU Dresden, Germany (chair) Ingrid Flemming, VRC University of Frankfurt, Germany (chair)

9:30 – 10:00 S.3.3.1 Vascular Redox Regulation: From homeostatic balance to oxidative stress

Ralf Brandes, Goethe-University Frankfurt, Germany

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10:00 – 10:15 S.3.3.2 Induced Pluripotent Stem Cells-derived Cardiomyocytes Improve Heart Function in Murine Model of Myocardial Infarction Józef Dulak, Jagiellonian University, Poland

10:15 – 10:30 S.3.3.3 Partial inhibition of the key glycolytic enzyme PFKFB3 in myeloid cells

impacts whole-body immune cell and liver metabolism, but not atherogenesis Jenny de Bruijn, Maastricht University, The Netherlands

10:30 – 11:00 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 11:00 – 12:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 3.4 Vascular cell plasticity and clonality Guido Krenning, University of Groningen, The Netherlands (chair) Elisabetta Dejena, University of Milan, Italy (chair)

11:00 – 11:30 S.3.4.1 Endothelial to Mesenchymal Transition and Endothelial Cell Plasticity Jason Kovacic, Icahn School of Medicine, New York, USA

11:30 – 12:00 S.3.4.2 Smooth muscle cell plasticity in atherosclerosis. Role of S100A4 Marie-Luce Bochaton-Piallat, University of Geneva, Switzerland 12:00 – 12:15 S.3.4.3 Single cell transcriptome analyses reveal novel targets modulating cardiac

neovascularisation by resident endothelial cells following myocardial infarction Mairi Brittan, University Of Edinburgh, United Kingdom 12:15 – 12:30 S.3.4.4 Towards a molecular atlas of the mouse vasculature Michael Vanlandewijck, Karolinska Institute, Sweden 11:00 – 12:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 3.5 Clinical microvascular dysfunction in cardiometabolic diseases Coen Stehouwer, Maastricht University, The Netherlands (chair) Anton-Jan van Zonneveld, LUMC Leiden, The Netherlands (chair)

11:00 – 11:30 S.3.5.1 Clinical aspects of microvessel dysfunction in cardiometabolic disease Rhian Touyz, University of Glasgow, United Kingdom 11:30 – 11:45 S.3.5.2 Epigenetic regulation of the glomerular endothelial glycocalyx by Enhancer of

Zeste Homolog-2 (EZH2) histone methyltransferase in diabetic nephropathy Marloes Sol, University Medical Center Groningen, The Netherlands 11:45 – 12:00 S.3.5.3 Barcoding in obese: who’s at increased risk for the development of

cardiovascular disease? Margaux Fontaine, Maastricht University, The Netherlands

12:00 – 12:15 S.3.5.4 Markers of Microvascular Dysfunction Are Associated With Incident

Depressive Symptoms: The Maastricht Study Anouk Geraets, Maastricht University, The Netherlands

12:15 – 12:30 S.3.5.5 Effect of L-NMMA on microvascular blood flow and glucose metabolism after

an oral glucose load Alexandra Högstedt, Linköping University, Sweden 12:30 – 13:00 Lunch Break and Exhibition (Exhibition Area Level 0 and 1)

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13:00 – 14:00 PLENARY ROOM 0.4/0.5 Brussels/Paris – Lunch Session See Details Page 48 Lunch S.3A Industry sponsor lunch symposia / Retinal Vessel Analysis Henner Hanssen, University Basel, Switzerland (chair) Doreen Schmidl, University of Austria, Vienna (chair)

13:00 – 13:15 Lunch S.3A.1 Retinal Vessel Analysis: a biomarker of cardiovascular risk  Henner Hanssen, University Basel, Switzerland 13:15 – 13:30 Lunch S.3A.2 Retinal microvascular dysfunction in heart disease A. Flammer, University Herzzentrum, Zürich, Switzerland

13:30 – 13:45 Lunch S.3A.3 Retinal vessel imaging: predictor for mortality in end stage renal disease – The ISAR study Christoph Schmaderer, Abteilung Für Nephrologie Klinikum Munich, Germany 

13:45 – 14:00 Lunch S.3A.4 Microvascular dysfunction in obesity and diabetes: causes, consequences

and actions Boy Houben, Maastricht University, The Netherlands 13:00 – 13:30 2.1 Colorado See Details Page 48 Lunch S.2B Industry sponsor lunch symposia / deoxyhemoglobin vasodilator

13:00 – 13:15 Lunch S.3B.1 Efficacy of Transdermal CO2 Administration Using the deoxyhemoglobin vasodilator Medical Device to Treat Diabetic Foot Ulcers

Ito Puruhito, Airlangga University Medical Facility, Indonesia 14:00 – 14:15 change session rooms 14:15 – 15:45 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 3.6 Vascular Pathophysiology, diagnostics, and treatment Erik Biessen, Maastricht University, The Netherlands (chair) Margreet de Vries, Leiden UMC, The Netherlands (chair)

14:15 – 14:45 S.3.6.1 Non-coding RNA control of pathological vascular remodelling Andrew Baker, University of Edinburgh, United Kingdom

14:45 – 15:00 S.3.6.2 Adventitial interleukin-6 release is critical for neointima formation

Jochen Dutzmann, University Hospital of Halle, Germany 15:00 – 15:15 S.3.6.3 Dynamic retinal vessel analysis in arterial hypertension: how different parameters

create a whole picture Konstantin Kotliar, Aachen University, Germany

15:15–15:30 S.3.6.4 The Macroscreen Platform: Sensing cardiovascular disease associated microenvironment Lieve Temmerman, Carim Maastricht University, The Netherlands

15:30 – 15:45 S.3.6.5 Endothelial C-Type Natriuretic Peptide Acts on Perivascular Mast Cells to Inhibit

Postischemic Vascular Inflammation and Thrombosis Wen Chen, University of Wuerzburg, Germany

27ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

14:15 – 15:45 CONCURRENT SESSION ROOM 2.1 Colorado Session 3.7 Resistance arteries Ed van Bavel, University of Amsterdam, The Netherlands (chair) Nicola Brown, University of Sheffield, United Kingdom (chair)

14:15 – 14:45 S.3.7.1 The negative side of life – the calcium activated chloride conductances in vascular smooth muscle cells.

Christian Aalkjaer, Aarhus University, Denmark 14:45 – 15:00 S.3.7.2 Collagen IV Is Required for Regulation of Endothelial Cell Mediated

Vascular Function Sarah McNeilly, University of Glasgow, United Kingdom 15:00 – 15:15 S.3.7.3 Preserved Cardiovascular Homeostasis Despite Blunted Acetylcholine-

induced Dilation in Mice with Endothelial Muscarinic M3 Receptor Deletion Cor de Wit, Universität Lübeck, Germany 15:15 – 15:30 S.3.7.4 The Effect of Two Weeks of Leg Immobilisation and Intense Aerobic

Exercise Training on Endothelial Function Nicolai Rytter, University of Copenhagen, Denmark

15:30 – 15:45 S.3.7.5 The Conducted Response as an Electrical Pliant Process: Reimagining Cell

Signaling in the Arterial Wall Donald Welsh, University Of Western Ontario, Canada

15:45 – 16:15 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 16:15 – 17:00 PLENARY ROOM 0.4/0.5 Brussels/Paris – Keynote Session 3.8 Clinical imaging of vascular disease Judith Sluimer, Maastricht University, The Netherlands (chair) Jozef Dulak, Jagellonian University, Poland (chair)

16:15 – 17:00 Clinical imaging of vascular disease Keynote: Dave Newby, Edinburgh University, United Kingdom 17:00 – 18:30 Poster Session, Exhibition and drinks (Exhibition Area Level 0 and 1) 18:30 – 19:30 make your way to the conference Party 19:30 – Conference Party and Dinner – Rebelle open ended

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28 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Thursday, April 18, 2019 8:30 – 9:10 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 4.1 EVBO lecture

Friedmann Kiefer, Max Plank inst. for molecular Biomedicine, Münster, Germany (chair) Judith Sluimer, Maastricht University, The Netherlands (chair)

8:30 – 9:10 Using multispectral genetic mosaics to enlighten endothelia heterogeneity during angiogenesis Rui Miguel Benedito, CNIC Madrid, Spain

9:10 – 9:15 Quick break to change session rooms 9:15 – 10:30 CONCURRENT SESSION ROOM 0.4/0.5 Brussels/Paris Session 4.2 Endothelial metabolism and mitochondrial function in

angiogenesis Ferdinand Le Noble, Karlsruhe Institue of Technology KIT, Germany (chair) Stephan Huveneers, Academic Medical Center Amsterdam, The Netherlands (chair)

9:15 – 9:35 S.4.2.1 Metabolite signaling in the vascular endothelium Michael Potente, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany 9:35 – 9:55 S.4.2.2 Developmental and tumor angioegnesis requires changes in endothelial cell mitochondrial shape Luca Scorrano, University of Padova, Italy 9:55 – 10:15 S.4.2.3 Redox metabolism in angiogenesis Massimo Santoro, University of Padova, Italy 10:15 – 10:30 S.4.2.4 Endothelial-specific Deletion of Autophagy Protein 5 attenuates ischemia-related

Angiogenesis David Sprott, TU Dresden, Germany 9:15 – 10:30 CONCURRENT SESSION ROOM 2.1 Colorado Session 4.3 Vascular drug targeting Jan Kamps, UMC Groningen, The Netherlands (chair) Fional Wilkinson, Manchester Metropolitan University, United Kingdom (chair)

9:15 – 9:45 S.4.3.1 Editing gene expression in endothelial cells in vivo using nanoparticle-directed siRNA and Cas9 delivery

James Dahlman, Georgia Institute of Technology, Atlanta, USA 9:45 – 10:00 S.4.3.2 Targeted liposomal delivery of NF-_B siRNA to endothelial cells abrogates anti-

MPO antibody-induced glomerulonephritis Jan Kamps, UMC Groningen, The Netherlands

10:00 – 10:15 S.4.3.3 Unraveling the selective accumulation of highly unusual liposomes to the blood

brain barrier in embryonic zebrafish Gabriela Arias Alpízar, Leiden University, The Netherlands

10:15 – 10:30 S.4.3.4 Tumour vascular normalisation through inhibition of LRG1 improves the

microenvironment and augments immunotherapy John Greenwood, University College London, United Kingdom

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10:30 – 11:00 Coffee Break and Exhibition (Exhibition Area Level 0 and 1) 11:00 – 11:45 PLENARY ROOM 0.4/0.5 Brussels/Paris Session 4.4 Awards Boy Houben, Maastricht University, The Netherlands (chair) Henning Morawietz, TU Dresden, Germany (chair)

11:00 – 11:45 ESM Malpighi Award Lecture: Akos Koller: Going with the flow in microcirculation Akos Koller, University of Physical Education, Budapest, Hungary 11:45 – 12:15 JVR / ESM Award lecture: Lydia Sorokin: The role of endothelial laminins in vascular function Lydia Sorokin, University of Muenster, Germany 12:15 – 12:30 Servier Award / Travel and Poster Awards & Closing 12:30 * Departure

30 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Awards1. Malpighi Lecture

This is the most prestigious award of the European Society for Microcirculation (ESM). It is given to an individual with an internationally outstanding reputation in any field of microcirculation and microvascular research. The individual will deliver the prestigious Malpighi Lecture at the forthcoming ESM meeting in Maastricht, NL, April, 15-18, 2019 and will receive the Gold Malpighi Medal and a life-long Membership of the ESM.

The Malpighi Award Committee is constituted by: the President, the Secretary-General, the Treasurer, one other representative of the ESM Executive Committee and the last two Awardees (if available). Voting is by secret ballot.

The 2019 ESM - Malpighi Award winner is: Prof. dr. Akos Koller (Budapest, Hungary). He will deliver his award lecture (Going with the flow in microcirculation) on Thursday April 18, 11:00h.

2. The Journal of Vascular Research (JVR/ESM) Award

The Journal of Vascular Research (JVR/ESM) Award and Lecture aims to spotlight important and growing fields of research, with high impact for vascular biology and the microcirculation with the goal of giving an award to one of the most prominent researchers in the field.

The 2019 JVR-ESM Award winner is: Prof. dr. Lydia Sorokin (Muenster, Germany). She will deliver her award lecture on Thursday April 18, 11:45h.

3. Servier Award for Microcirculation

This award is offered by SERVIER in partnership with the European Society for Microcirculation for an outstanding publication on microcirculation/vascular biology in basic or clinical research (4000 Euro). The proposed publication must be original research, of international relevance and impact and be consistent with the main objectives of the ESM.

The committee for the Servier Award in Microcirculation includes: the President, Secretary-General, Treasurer, one other representative of the ESM Executive Committee and the last two Servier Awardees (if available). Voting is by secret ballot.

The 2019 Servier Award winner is: dr. Tamara Girbl (London, UK), based on the paper: Girbl et al, Immunity 2018: 49, 1062–1076. Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis. She will receive the award on Thursday April 18.

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Awards4. EVBO Lecture Award

The EVBO Lecture is awarded by the Council every 2 years at the EVBO conference, where the lecturer receives reimbursement of registration and travel costs to the conference. Awardees must be members of the EVBO (application for membership can be made online). The Prize is awarded to a young scientist within 10 years of PhD who, in the judgment of the awards Committee, has published work of a high standard with exceptional promise to become an international leader in vascular science. The list of candidates is drawn up by the Medals Committee from names put forward by the EVBO Council members, and the meeting hosts, the winner is selected by this judging panel and ratified by the council.

The EVBO lecture will be delivered this year by Rui Miguel Benedito (Spain), who will be speaking in Session 4.1 on Thursday April 18, at 8:30am.

5. EVBO Medal Award

The EVBO Medal is awarded by the European Vascular Biology Organisation to an individual who, in the judgment of the EVBO Council, has made a sustained, outstanding contribution to the development of vascular science and whose research has had a significant international impact. A list of candidates is drawn up by the Medals Committee from names put forward both by the EVBO Council, and following an invitation for nominations from the membership. Taking into consideration, the meeting hosts and their programme, all Council members then take a vote.

The EVBO medal lecture will be delivered this year by Professor Elisabetta Dejana, Institute Of Molecular Oncology Foundation, Italy, at the forthcoming EVBO meeting in Maastricht, April, 15-18, 2019, during Session 1.1 on Monday April 15, 13:15.

6. EVBO Travel AwardsThe European vascular biology organization will be awarding 10 travel awards. www.evbo.org.

7. ESM Travel AwardsThe European Society of Microcirculation will be awarding 5 Early Career Investigators Travel Awards and 5 Early Career Investigator Travel Awards for less-developed countries.

8. ESM Poster AwardsESM will be awarding 5 poster awards. www.esm.org

9. MiVaB Travel GrantsThe Dutch Society for Microcirculation and Vascular biology awards to 3 best presentations.

10. German Microcirc Society (GfMVB) Poster Awards

The German Microcirc Society (GfMVB) will be awarding 3 poster awards.

www.gmfvb.com

32 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Social EventsWelcome Reception

Monday April 15, 2019

Time : 18:00 – 19:00

Address: Maastricht Town Hall,

Markt 78, 6211 CL Maastricht

On Monday evening you are invited between

18:00 – 19:00 by the city of Maastricht to attend

the ESM-EVBO 2019 welcome-reception at the

Maastricht historic town hall. (This venue can take a maximum of 300 delegates (based on

first come, first serve basis); please tick the box during your registration).

In Dutch the town hall is called “Stadhuis” and it’s located in the centre of Maastricht, sited

on the Markt. The building was designed by Pieter Post in the 17th century in the style of

Dutch classicism.

Getting there

There are no conference shuttle buses available.

• A taxi from MECC to the town hall will take approx 10-15 min depending traffic

(cost approx 15 EUR).

• You can use one of the public buses, running every 10 min (line 1, 6, 10 or 57)

which will take approx 20-25 min (cost approx 2.00 EUR, tickets can be purchased

directly in the bus).

During the remaining evening, you are free to enjoy Maastricht nightlife with its 400 bars

and restaurants.

33ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Conference Party Rebelle Maastricht

Wednesday April 17, 2019

Time : 19:30 – open ended

Address: Rebelle Maastricht, Kesselskade 43,

6211 EN Maastricht, Price: 75 EUR

Join us for the Conference Dinner and Party

@ Rebelle Maastricht. Rebelle is located in

the 17th century Augustinian church, in the

city center, on the banks of the river Maas.

This historical monument has a more than

impressive interior with a special appearance

by its high ceilings, great windows and was

recently transformed in a party venue.

In 2018 they were awarded with the price of

best party venue in the South! Following an

opening drink and a surprise performance

typical for Maastricht, you can enjoy

different dishes, served at various buffets.

As a grand dessert the party will open by a

SPECTACULAR performance in Maastricht

style. Let’s rock ESM-EVBO !!!

Getting there

There are no conference shuttle buses available.

• a taxi from MECC to Rebelle will take approx 10-15 min depending traffic (cost

approx 15 EUR)

• Use one of the public buses, running every 10 min (line 1, 5, 15 or 57) which will

take approx 20-25 min (cost approx 3.00 EUR, tickets can be purchased directly in

the bus, no cash).

34 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Early Career Scientist BBQ and Party

Tuesday April 16, 2019

Times:19:00 -open ended

Address: Stayokay Maastricht,

Maasboulevard 101, 6211 JW Maastricht

Price: 35 EUR

Limited to 150 people

A networking extravaganza!!

Kick-starting the night off will be a lovely BBQ spread on the balcony overlooking the Maas.

Providing the perfect opportunity to socialise and network with other young investigators

within the field; before having your brains and wits challenged by our all-encompassing

Pub Quiz. With questions ranging from the mundane to the extraordinary, all knowledge will

be tested. The night will be closed off with a party at the Stayokay in celebration of the new

friendships made.

Getting there

• A taxi from MECC to Stayokay will take approx. 10mins depending on traffic (cost

approx. 12 EUR) or you can use the public transport, Buses running every 10

minutes (line 1, 5, 10 or 57) which will take approx. 25-30 min (cost approx. 3.00

EUR, tickets can be obtained directly on the bus, no cash).

• Depending on the weather, there is an opportunity to walk by foot (approx. 30min)

or cycle (approx. 10min).

Join us for an early 5km run through Maastricht on Tuesday April 16, 2019!

Do you want to discover Maastricht in a different

way? On Tuesday April 16th, we are organizing

a 5km run through the city. You will discover all

the beautiful hidden corners of Maastricht and

exercise at the same time. Meeting point is at the hostel StayOkay (Maasboulevard 101,

Maastricht) at 7am, sharp! See you there.

35ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Poster Numbers

Presenting Author Names

Paper Title

TUEP001 Renée Tillie PDGF-B Retention Motif Deletion Has Mural Cell-Independent Effects Including Leukocytosis And Increased Murine Atherosclerotic Plaque Stability Due To Macrophage Apoptosis And Decreased MMP Activity

TUEP002 Maria Filippova Atypical adhesion molecule T-cadherin is a novel regulator of pericyte function.

TUEP003 Emmanuel Nwadozi

Nutrient-Overload Induces Leptin Production by Skeletal Muscle Pericytes: Implications for Capillary Remodelling

TUEP004 Józef Dulak miR-378a influences vascularization in skeletal muscles

TUEP005 Nicola Jane Brown Breast Cancer Metastasis To Bone: The Role Of The Perivascular Niche In Regulating Tumour Cell Dormancy

TUEP007 Evangelia Papadimitriou

Interaction of moesin with ανβ3 integrin regulates endothelial cell migration

TUEP008 Sohni Ria Bhalla Wnt5A Dependent Revascularisation After Ischemia Is SRPK1 Dependent

TUEP009 Ito Puruhito Efficacy of Transdermal CO2 Administration Using the D’OXYVA® Medical Device to Treat Diabetic Foot Ulcers

TUEP011 Alexandra Hoeh Leucine-rich alpha-2-glycoprotein-1 Disrupts Vessel Maturation in Developmental Retinal Angiogenesis

TUEP012 Alexandra Njegic Essential Role for Plasma Membrane Calcium ATPase 1 in Angiogenesis

TUEP013 Valeria Mastrullo Human Vascular Pericytes Express a Circadian Rhythmicity

TUEP014 Katarina Spiranec Spes

Distinct atrial natriuretic peptide-induced cGMP signalling pathways in astrocytes and pericytes attenuate retinal pathological neovascularization

TUEP015 Fabian Hahner The NADPH oxidase Nox4 promotes differentiation from induced pluripotent stem cells into endothelial cells

TUEP016 Caroline Kniebs Three-Dimensional Tumor Model Based on Alginate Beads in vitro

TUEP017 Ilaria Aurigemma Determining the role of the transcription factor TBX1 in endothelial cell differentiation

TUEP018 Tim Schader Nox4 promotes angiogenesis by oxidation of HDAC4 and abrogated MEF2A repression

TUEP019 Laia Gili Solé Effect of 3D Dynamic Culture on Human Stromal Vascular Fraction Cell Composition

TUEP020 Vincent Van Duinen

Perfused 3D angiogenic sprouting assay of iPSC-derived endothelial microvessels in vitro

PostersTuesday, April 16, 2019

36 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

TUEP021 Cyrine Ben Dhaou Regulation of tumor angiogenesis by chemerin and its receptors CHEMR23

TUEP022 Nikita Chernomorets

Epidermal growth factor in the treatment of trophic ulcers in the neuropathic form of diabetic foot syndrome.

TUEP023 Heidi Pulkkinen Crosstalk of VEGF-, BMP- and Hippo-signaling in Angiogenesis

TUEP024 Harsh Patolia Agent-Based Model Simulates Effect of Dose-Dependent Inhibition of Angiogenesis by Increasing Secretion of Extracellular Soluble PDGF Receptor-Beta by Pericytes

TUEP025 William Jackson High Fat Feeding Decreases Vascular Density in Rat Mesenteric Perivascular Adipose Tissue

TUEP026 Hermann J. Genn Influencing microcirculation in horses

TUEP027 Mahdieh Heydarigoojani

Thrombin receptor activating peptide (TRAP-6), promotes proliferation of human umbilical vein endothelial cell (HUVEC)

TUEP028 Adeline Yoke Yin Chia

Discovering potential acetylcholinesterase inhibitors using molecular docking against Alzheimer’s Disease and Angiogenesis

TUEP029 Fabiana Baganha Human IgG1 phosphorylcholine antibody reduces vein graft remodelling, intraplaque angiogenesis and intraplaque hemorrhage

TUEP030 Melissa King Influence of Bemer Blanket Technology on Pain Measures, Biomechanics and Serum Biomarkers in Horses with Back Pain

TUEP031 Gangqi Wang Shear stress regulates endothelial glycocalyx hyaluronan biosynthesis through HAS2 and metabolic regulation of its substrates

TUEP032 Christina Warboys Inflammatory Activation of Endothelial Cells Induced by Disturbed Flow is Regulated by Frizzled-4 and β-catenin via a Non-canonical Pathway

TUEP033 Patricia Mccallinhart

Human Cardiac Microvascular Endothelial Cell Stiffness and Adhesion to Extracellular Matrix Proteins in Type 2 Diabetes

TUEP034 Diana Schrick A novel approach of platelet function test to identify non-matured platelets having increased aggregatory effect

TUEP035 Cini Mathew John Targeting the endothelium with KCa channel activator SKA-31, improves vascular function and does not up regulate T cell activity in a rodent model of T2DM

TUEP036 Maria Globisch Dynamic molecular signatures of endothelial cells during postnatal development of the blood-brain barrier

TUEP037 María Del Carmen Ocaña

Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?

TUEP038 Jana Horvathova Simultaneous inhibition of glycolysis and multikinase receptor activity can have an additive effect on endothelial cell proliferation and migration

TUEP039 Camilla Hansen Mitochondria in skeletal muscle microvascular endothelial cells and the influence of glucose availability

37ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

TUEP021 Cyrine Ben Dhaou Regulation of tumor angiogenesis by chemerin and its receptors CHEMR23

TUEP022 Nikita Chernomorets

Epidermal growth factor in the treatment of trophic ulcers in the neuropathic form of diabetic foot syndrome.

TUEP023 Heidi Pulkkinen Crosstalk of VEGF-, BMP- and Hippo-signaling in Angiogenesis

TUEP024 Harsh Patolia Agent-Based Model Simulates Effect of Dose-Dependent Inhibition of Angiogenesis by Increasing Secretion of Extracellular Soluble PDGF Receptor-Beta by Pericytes

TUEP025 William Jackson High Fat Feeding Decreases Vascular Density in Rat Mesenteric Perivascular Adipose Tissue

TUEP026 Hermann J. Genn Influencing microcirculation in horses

TUEP027 Mahdieh Heydarigoojani

Thrombin receptor activating peptide (TRAP-6), promotes proliferation of human umbilical vein endothelial cell (HUVEC)

TUEP028 Adeline Yoke Yin Chia

Discovering potential acetylcholinesterase inhibitors using molecular docking against Alzheimer’s Disease and Angiogenesis

TUEP029 Fabiana Baganha Human IgG1 phosphorylcholine antibody reduces vein graft remodelling, intraplaque angiogenesis and intraplaque hemorrhage

TUEP030 Melissa King Influence of Bemer Blanket Technology on Pain Measures, Biomechanics and Serum Biomarkers in Horses with Back Pain

TUEP031 Gangqi Wang Shear stress regulates endothelial glycocalyx hyaluronan biosynthesis through HAS2 and metabolic regulation of its substrates

TUEP032 Christina Warboys Inflammatory Activation of Endothelial Cells Induced by Disturbed Flow is Regulated by Frizzled-4 and β-catenin via a Non-canonical Pathway

TUEP033 Patricia Mccallinhart

Human Cardiac Microvascular Endothelial Cell Stiffness and Adhesion to Extracellular Matrix Proteins in Type 2 Diabetes

TUEP034 Diana Schrick A novel approach of platelet function test to identify non-matured platelets having increased aggregatory effect

TUEP035 Cini Mathew John Targeting the endothelium with KCa channel activator SKA-31, improves vascular function and does not up regulate T cell activity in a rodent model of T2DM

TUEP036 Maria Globisch Dynamic molecular signatures of endothelial cells during postnatal development of the blood-brain barrier

TUEP037 María Del Carmen Ocaña

Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?

TUEP038 Jana Horvathova Simultaneous inhibition of glycolysis and multikinase receptor activity can have an additive effect on endothelial cell proliferation and migration

TUEP039 Camilla Hansen Mitochondria in skeletal muscle microvascular endothelial cells and the influence of glucose availability

TUEP040 Tatyana Grishacheva

The photodynamic effects on the microvasculature vessels

TUEP042 Silvia Martin Almedina

Investigating the Role of KIF11 in the Lymphatic Function of MCLID Patients

TUEP043 Kitti Ajtay Fetal Breathing Movements and Pulmonary Lymphatics Function Together to Prepare the Lung for Inflation at Birth

TUEP044 Christina Karapouliou

Functional Studies on the EPHB4 Signalling Pathway in Patients with Generalised Lymphatic Dysplasia

TUEP045 Zoltan Jakus Nucleoside-Modified VEGFC mRNA Induces Organ-Specific Lymphatic Growth and Reverses Experimental Lymphedema

TUEP046 Marie Ebroin New considerations of lymphatic endothelial cells as key players of the pro-tumoral microenvironment

TUEP047 Sonia Martial Unexpected Effects of Photontherapy and Protontherapy on VEGFC Production and Tumor Aggressiveness in Different Medulloblastoma Subgroups

TUEP048 Lionel Gillot Modification of lymph node microenvironment during tumor progression

TUEP049 James Oo Modulation of endothelial chromatin remodelling complexes by long non-coding RNAs

TUEP050 Candidate Eleni Liapi

Role of 5’GluCTC-tRNA half in human cardiac microvascular endothelial function

TUEP051 J Hung A Novel Macrophage Long Non-Coding RNA Expressed in Human Atherosclerosis

TUEP052 Agnieszka Jazwa-Kusior

Cardiac macrophages in myocardial infarction - role of heme oxygenase 1

TUEP053 Francesca Vacante Characterization of the LncRNA miR143HG in the pathophysiology of atherosclerosis

TUEP054 Shiping He microRNA-214 is a novel player in inflammatory smooth muscle cell differentiation and angioplasty restenosis

TUEP055 Gokhan Pehlivan Association of Skin Microvascular Function with Pulsatile and Resistive Hemodynamics

TUEP056 Sam Thomas Acute aerobic exercise increases systemic skin microvascular functional responses to post-occlusive reactive hyperaemia

TUEP057 Paulina Kowalewska

Deletion of Connexin 40 but not KIR2.1 Eliminates the Microvascular Response to Oxygen in Mouse Skeletal Muscle

TUEP058 Jo De Mey The Many Faces of Endothelium-Dependent Relaxation in Resistance Arteries from Patients with Residual Cardiovascular Disease

38 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

TUEP059 Daniel Henrion Flow-mediated vasodilatation in the mouse involves unliganted membrane, but not nuclear, estrogen receptor alpha

TUEP060 Angel Luis Armesilla

Plasma Membrane Calcium ATPase 4 gene expression is downregulated in pulmonary artery endothelial cells treated with inducers of pulmonary arterial hypertension

TUEP061 Yiannis Dimakopoulos Mr Konstantinos Giannokostas

Shear-induced NO/cGMP pathway and its impact on intravascular functionality.

TUEP062 Dorien De Munck Autophagy in vascular smooth muscle cells regulates large artery contractility and compliance in young C57Bl6 mice.

TUEP063 Myrthe van der Bruggen

In-Vitro Characterization of Mouse Carotid Artery Mechanics by Dynamic Biaxial Pressure-Myography

TUEP064 Arthur Leloup Vascular smooth muscle cell contraction and relaxation as a critical regulator of large artery compliance

TUEP065 Alexei Muravyov Microrheological behavior of red blood cells under the influence of gastransmitters as a model of the paracrine regulation in the vascular system

TUEP066 Brenda R Kwak Primary cilia affect the endothelial response to aneurysmal wall shear stress

TUEP067 Emmanouil Solomonidis

Single Cell RNA-Sequencing Reveals Plasmalemma Vesicle-Associated Protein (PLVAP) as a Novel Target with a Role in New Blood Vessel Formation in the Ischaemic Heart

TUEP068 Rolando Szilveszter Matos

Development of an Ex-vivo Model of Vascular Remodelling

TUEP069 Cai Astley Resveratrol-Loaded Nanostructured Lipid Carriers Restore Dilator Function Following Acute Pressure Elevation, Ex Vivo.

TUEP070 Marie Lang The Effects of Methotrexate on the Vascular Endothelium

TUEP071 Christian Ramakers Perfusable 3D angiogenesis in high throughput microfluidic culture platform

TUEP072 Christian Ramakers High-Throughput permeability assay on perfused 3D microvessels in vitro

TUEP073 Angelina Pavlic Sphingomyelin phosphodiesterase in targeted treatment of vascular calcification

TUEP074 Anna Maria Gdula Effect of Dual Purinoreceptor-Dependent Strategy on Endothelial Permeability and Cells Condition

TUEP076 Ziva Melik The effect of caffeine on cutaneous microcirculation in women

39ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

TUEP059 Daniel Henrion Flow-mediated vasodilatation in the mouse involves unliganted membrane, but not nuclear, estrogen receptor alpha

TUEP060 Angel Luis Armesilla

Plasma Membrane Calcium ATPase 4 gene expression is downregulated in pulmonary artery endothelial cells treated with inducers of pulmonary arterial hypertension

TUEP061 Yiannis Dimakopoulos Mr Konstantinos Giannokostas

Shear-induced NO/cGMP pathway and its impact on intravascular functionality.

TUEP062 Dorien De Munck Autophagy in vascular smooth muscle cells regulates large artery contractility and compliance in young C57Bl6 mice.

TUEP063 Myrthe van der Bruggen

In-Vitro Characterization of Mouse Carotid Artery Mechanics by Dynamic Biaxial Pressure-Myography

TUEP064 Arthur Leloup Vascular smooth muscle cell contraction and relaxation as a critical regulator of large artery compliance

TUEP065 Alexei Muravyov Microrheological behavior of red blood cells under the influence of gastransmitters as a model of the paracrine regulation in the vascular system

TUEP066 Brenda R Kwak Primary cilia affect the endothelial response to aneurysmal wall shear stress

TUEP067 Emmanouil Solomonidis

Single Cell RNA-Sequencing Reveals Plasmalemma Vesicle-Associated Protein (PLVAP) as a Novel Target with a Role in New Blood Vessel Formation in the Ischaemic Heart

TUEP068 Rolando Szilveszter Matos

Development of an Ex-vivo Model of Vascular Remodelling

TUEP069 Cai Astley Resveratrol-Loaded Nanostructured Lipid Carriers Restore Dilator Function Following Acute Pressure Elevation, Ex Vivo.

TUEP070 Marie Lang The Effects of Methotrexate on the Vascular Endothelium

TUEP071 Christian Ramakers Perfusable 3D angiogenesis in high throughput microfluidic culture platform

TUEP072 Christian Ramakers High-Throughput permeability assay on perfused 3D microvessels in vitro

TUEP073 Angelina Pavlic Sphingomyelin phosphodiesterase in targeted treatment of vascular calcification

TUEP074 Anna Maria Gdula Effect of Dual Purinoreceptor-Dependent Strategy on Endothelial Permeability and Cells Condition

TUEP076 Ziva Melik The effect of caffeine on cutaneous microcirculation in women

TUEP077 Maud Martin How to build a polarized endothelial cell: non-centrosomal microtubules and not the centrosome control endothelial cell polarity and sprouting angiogenesis

TUEP078 Maximiliano Arata Coagulation factor Xa promotes metastasis through endothelial cells activation

TUEP079 Anoek van Leeuwen

Downregulation of Tie2 Induces Microvascular Leakage in Mice

TUEP080 Lucie E Bourne N-acetylcysteine Limits Arterial Medial Calcification But Preserves Bone Formation

TUEP081 Daniëlle Coenen PDE3 and -5 Inhibition Differentially Affects Platelet Function under Hemostatic and Inflammatory Conditions

TUEP082 James Walker Eph-Ephrin Signalling Patterns Early Venous Valve Formation

TUEP083 Anton Kutikhin Calcium phosphate bions promote intimal hyperplasia in intact arteries even upon normolipidemic conditions by causing endothelial injury through lysosome-dependent cell death

TUEP084 Martina Mihalj Short Term Blockade of Angiotensin II Type 1 Receptor by Losartan Effects on Blood Leukocyte Subpopulations’ ROS and RNS Levels in Sprague-Dawley Rats

TUEP085 Francesca Del Gaudio Daniel V. Oliveira

Characterization of a Novel CADASIL-like Mutation in the Notch3 Receptor

TUEP086 Xiaohua Guo Mdia1 is Crucial for Advanced Glycation End Product-In-duced Endothelial Hyperpermeability

TUEP088 Franziska Werner Autocrine C-type natriuretic peptide signalling improves macrovascular endothelial functions and prevents arterial stiffness

TUEP090 Mieke Karel Injury-induced vascular changes and thrombus activity after aspirin or rivaroxaban treatment in mice

TUEP091 Írisz Szabó Antagonism of Prostaglandin Signaling Involving FP-Receptors Inhibits the Evolution of Spreading Depolarization in Cerebral Ischemia

TUEP092 Timara Kuiper Protein Tyrosine Kinase Activity Profiling Reveals Novel Signal Transduction Pathways of LPS-Induced Inflammatory Responses in Endothelial cells in vitro

TUEP093 Anne-marie Fors Connolly

MMP9 Associates with Endothelial Glycocalyx Degradation During Haemorrhagic Fever with Renal Syndrome

TUEP094 Kapka Miteva Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

TUEP095 Pranitha Kamat Machine Learning to Automatically Identify and Evaluate Intimal Hyperplasia in Histological Sections

TUEP096 Pranitha Kamat Adipose Derived Mesenchymal Stem Cell Delivered Endothelial Protection during Graft Vasculopathy

40 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

TUEP097 Michael R McDermott

Aortic Valve Regurgitation Causes a Mild Improvement in Coronary Flow Velocity Reserve in the Type 2 Diabetic db/db Mouse

TUEP098 Geoffrey Van den Bergh

Using a Mouse Model of Vascular Media Calcification to Unravel the Pathophysiology Behind Arterial Stiffness

TUEP099 Nicola Edwards Improving Stratification of Cardiovascular Risk in Systemic Lupus Erythematosus using Endothelial Microvesicles as Novel Biomarkers

TUEP100 Mohamed Essameldin Abdelgawad

Novel Optimized Cell Culture Medium for Growth and Maintenance of Endothelial-like Cells and Endothelial Progenitor Cells with minimal serum

TUEP101 Mohamed Essameldin Abdelgawad

Development of a Novel Angiogenic Score for Early Detection of Hepatocellular Carcinoma among High-risk Hepatitis C Virus Patients

TUEP102 ASMA ALONAZI Potential Role for G Protein Coupled Receptor Kinase 2 in Vasoconstrictors-stimulated Vascular Smooth Muscle Cell Proliferation via MAPK/ERK Signalling Pathway

TUEP103 Luís Miguel Cardoso Dos Santos

Role of apelin in vascular smooth muscle cell phenotypic transition: a proatherogenic factor for atherosclerosis

TUEP104 László Hejjel Autonomic Actions of Physical Vascular Therapy in Ischemic Heart Disease Patients by Heart Rate Variability Analysis

TUEP105 Elena Gavrilova Evaluation of the Vasomotor Function of the Microvessels Using Laser Doppler Flowmetry in Critically ill Patients as a Way to Determine Functional Reserves

TUEP106 Zulfia Zaripova Gravitational Therapy Using Dynamic Inversion Table to Improve Microcirculation and Increase Exercise Tolerance in Healthy Athletes

TUEP107 Ksenija Cankar Nutritional and functional blood flow in glabrous and nonglabrous skin: can they be separately measured

TUEP108 Wolf Balliel PEMF in REHAB at Extreme Sport - Special Case

TUEP109 Wolf Balliel Specific PEMF-Treatment in hypertension therapy - Cases

TUEP110 David Low The Effects of Acute Exercise on Thermal Sensory Function

TUEP111 Sabrina Boumendjel

Genetic polymorphism of apolipoprotein E in hemorrhagic stroke: study case-control

TUEP112 Olivia WaringHan JinDr Pieter GoossensDr Marjo DonnersProf. Erik Biessen

Dissecting the Link Between Microcalcification and Macrophage-Led Inflammation in the Vasculature

TUEP113 Ilaria Passalacqua A Potential Role for Extracellular Vesicle-Mediated Communication from Smooth Muscle Cells to Endothelial Cells in Development of Human Pulmonary Arterial Hypertension

41ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

TUEP097 Michael R McDermott

Aortic Valve Regurgitation Causes a Mild Improvement in Coronary Flow Velocity Reserve in the Type 2 Diabetic db/db Mouse

TUEP098 Geoffrey Van den Bergh

Using a Mouse Model of Vascular Media Calcification to Unravel the Pathophysiology Behind Arterial Stiffness

TUEP099 Nicola Edwards Improving Stratification of Cardiovascular Risk in Systemic Lupus Erythematosus using Endothelial Microvesicles as Novel Biomarkers

TUEP100 Mohamed Essameldin Abdelgawad

Novel Optimized Cell Culture Medium for Growth and Maintenance of Endothelial-like Cells and Endothelial Progenitor Cells with minimal serum

TUEP101 Mohamed Essameldin Abdelgawad

Development of a Novel Angiogenic Score for Early Detection of Hepatocellular Carcinoma among High-risk Hepatitis C Virus Patients

TUEP102 ASMA ALONAZI Potential Role for G Protein Coupled Receptor Kinase 2 in Vasoconstrictors-stimulated Vascular Smooth Muscle Cell Proliferation via MAPK/ERK Signalling Pathway

TUEP103 Luís Miguel Cardoso Dos Santos

Role of apelin in vascular smooth muscle cell phenotypic transition: a proatherogenic factor for atherosclerosis

TUEP104 László Hejjel Autonomic Actions of Physical Vascular Therapy in Ischemic Heart Disease Patients by Heart Rate Variability Analysis

TUEP105 Elena Gavrilova Evaluation of the Vasomotor Function of the Microvessels Using Laser Doppler Flowmetry in Critically ill Patients as a Way to Determine Functional Reserves

TUEP106 Zulfia Zaripova Gravitational Therapy Using Dynamic Inversion Table to Improve Microcirculation and Increase Exercise Tolerance in Healthy Athletes

TUEP107 Ksenija Cankar Nutritional and functional blood flow in glabrous and nonglabrous skin: can they be separately measured

TUEP108 Wolf Balliel PEMF in REHAB at Extreme Sport - Special Case

TUEP109 Wolf Balliel Specific PEMF-Treatment in hypertension therapy - Cases

TUEP110 David Low The Effects of Acute Exercise on Thermal Sensory Function

TUEP111 Sabrina Boumendjel

Genetic polymorphism of apolipoprotein E in hemorrhagic stroke: study case-control

TUEP112 Olivia WaringHan JinDr Pieter GoossensDr Marjo DonnersProf. Erik Biessen

Dissecting the Link Between Microcalcification and Macrophage-Led Inflammation in the Vasculature

TUEP113 Ilaria Passalacqua A Potential Role for Extracellular Vesicle-Mediated Communication from Smooth Muscle Cells to Endothelial Cells in Development of Human Pulmonary Arterial Hypertension

WEDP001 Brenda R Kwak Gender differences and similarities in the resolution of intraluminal thrombosis in a rat aneurysm model

TUEP114 Thomas Sarazin TSP-1:CD47 Orthosteric Antagonist TAX2 Peptide hasPlatelet Anti-aggregating and Antithrombotic Activities

WEDP002 Danielle Kerkhofs Vascular cognitive impairment in experimental hypertension: the microglial culprit

WEDP003 Clifton Houk Characterization of Germinal Matrix Vasculature in the Early Postnatal Mouse Brain

WEDP004 Marina Leardini-Tristão

The impact of early physical exercise on brain microcirculation, synaptic proteins and cognitive function in a chronic model of cerebral hypoperfusion

WEDP005 Takashi Koizumi Impact of Diabetes on Hypertension-Induced Cerebral Small Vessel Disease

WEDP006 Anita Matic Angiotensin II supplementation by miniosmotic pumps reduces the level of oxidative stress induced by high dietary salt intake in rat microcirculation

WEDP007 Johan Van De Voorde

Search for the source of the retinal relaxing factor

WEDP008 Christian Ramakers BBB on-a-chip: a 3D in vitro model of the human blood brain barrier (BBB)

WEDP009 Donald G. Welsh Lipid Regulation of KIR2.x Channels and the Enabling of Hemodynamic Sensing in Cerebral Arteries

WEDP010 Dorien Hermkens The protective function of intracranial endothelial cells in vascular cognitive impairment

WEDP011 Karin Wårdell Cerebral microcirculation recording with laser Doppler flowmetry in neurosurgery

WEDP012 Chonticha Wongchaiya

Pomelo Extract Attenuates Cerebral Endothelial Dysfunction Through Activating PI3K-Akt-eNOS Pathway in A Rat Model of Type 2 diabetes

WEDP013 Zrinka Mihaljevic Angiotensin II-type 1 Receptor Blockade with Losartan Affects the Expression of Enzymes Involved in Vascular Reactivity and Balance of Vascular Oxidative Stress of Sprague-Dawley Rats

WEDP014 Elizabeth Illingworth

Defining Vegfr3-Tbx1 interactions in brain vascular development

Wednesday, April 17, 2019

42 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

WEDP015 Rajkumar Rajanathan

Abnormal K+-signaling in Cerebral Arteries Disturbs Neurovascular Coupling in Mouse Model for Migraine.

WEDP016 Hanna Jonasson Oxygen Saturation in Skin Microcirculation as a Predictor for Cardiovascular Disease

WEDP017 Sytze Rensma Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study

WEDP018 Wenjie Li Prediabetes and Type 2 Diabetes are Associated with Wider Retinal Arterioles and Venules

WEDP019 Nathalie Obadia Evidence of the TLR4 participation on the impact of metabolic syndrome on brain microcirculation and cognitive function

WEDP020 Wayne Smith Retinal Vessel Caliber and Vessel Reaction to Light Flicker in True Normotensive Young Healthy Black and White Adults: the African-PREDICT Study

WEDP022 Andriana Margariti Establishing human diabetic and cardiovascular disease models in a petri dish through cell reprogramming

WEDP023 Rui Ning Chia Role of Leucine-Rich alpha-2-Glycoprotein 1 (LRG1) in Diabetes-Related Ischaemic Heart Diseases

WEDP024 David Strain The Impact Of Diabetes, Cardiovascular Disease And Weight Change On Microvascular Function; Results Of A Three-Year Longitudinal Observational Study.

WEDP026 Sabrina Köchli Obesity, high blood pressure and physical activity determine vascular phenotype in young children: the EXAMIN YOUTH Study

WEDP027 Mitko Veta Retinal Microvascular Biomarker Extraction on Fundus Images from the Maastricht Study Using Supervised Deep Learning

WEDP028 Ayushi Singh Long Term Cardiac and Vascular Changes in Women with a History of Hypertensive Disorders of Pregnancy: A Case-Control Study

WEDP029 Christina Svensson Cerebral hemodynamics and microcirculatory function in patients with Systemic Lupus Erythematosus

WEDP030 EDUARDO TIBIRICA

Penile Microvascular Endothelial Reactivity in Hypertensive Patients with Erectile Dysfunction: Effects of a Chronic Treatment with Sildenafil

WEDP031 EDUARDO TIBIRICA

Effects of acute postprandial hyperglycemia on microvascular endothelial-dependent vasodilation

WEDP032 Nikita Chernomorets

Gravitational therapy in the complex treatment of patients with complications of diabetes.

WEDP033 Tos TJM Berendschot

Characteristics Of The Retinal Microvasculature In Association With Cardiovascular Risk Markers In Children With Overweight, Obesity And Morbid Obesity

43ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

WEDP015 Rajkumar Rajanathan

Abnormal K+-signaling in Cerebral Arteries Disturbs Neurovascular Coupling in Mouse Model for Migraine.

WEDP016 Hanna Jonasson Oxygen Saturation in Skin Microcirculation as a Predictor for Cardiovascular Disease

WEDP017 Sytze Rensma Microvascular Dysfunction Is Associated with Worse Cognitive Performance: The Maastricht Study

WEDP018 Wenjie Li Prediabetes and Type 2 Diabetes are Associated with Wider Retinal Arterioles and Venules

WEDP019 Nathalie Obadia Evidence of the TLR4 participation on the impact of metabolic syndrome on brain microcirculation and cognitive function

WEDP020 Wayne Smith Retinal Vessel Caliber and Vessel Reaction to Light Flicker in True Normotensive Young Healthy Black and White Adults: the African-PREDICT Study

WEDP022 Andriana Margariti Establishing human diabetic and cardiovascular disease models in a petri dish through cell reprogramming

WEDP023 Rui Ning Chia Role of Leucine-Rich alpha-2-Glycoprotein 1 (LRG1) in Diabetes-Related Ischaemic Heart Diseases

WEDP024 David Strain The Impact Of Diabetes, Cardiovascular Disease And Weight Change On Microvascular Function; Results Of A Three-Year Longitudinal Observational Study.

WEDP026 Sabrina Köchli Obesity, high blood pressure and physical activity determine vascular phenotype in young children: the EXAMIN YOUTH Study

WEDP027 Mitko Veta Retinal Microvascular Biomarker Extraction on Fundus Images from the Maastricht Study Using Supervised Deep Learning

WEDP028 Ayushi Singh Long Term Cardiac and Vascular Changes in Women with a History of Hypertensive Disorders of Pregnancy: A Case-Control Study

WEDP029 Christina Svensson Cerebral hemodynamics and microcirculatory function in patients with Systemic Lupus Erythematosus

WEDP030 EDUARDO TIBIRICA

Penile Microvascular Endothelial Reactivity in Hypertensive Patients with Erectile Dysfunction: Effects of a Chronic Treatment with Sildenafil

WEDP031 EDUARDO TIBIRICA

Effects of acute postprandial hyperglycemia on microvascular endothelial-dependent vasodilation

WEDP032 Nikita Chernomorets

Gravitational therapy in the complex treatment of patients with complications of diabetes.

WEDP033 Tos TJM Berendschot

Characteristics Of The Retinal Microvasculature In Association With Cardiovascular Risk Markers In Children With Overweight, Obesity And Morbid Obesity

WEDP034 Kim Gooding Association Between Sural Nerve Conductance Amplitude and Skin Microvascular Responsiveness in Individuals With and Without Type 2 Diabetes Across the Subclinical Neuropathy Range

WEDP035 Irina Tikhomirova Effect of gasotransmitters on erythrocyte microrheological properties in non-diabetic subjects and in patients with type 2 diabetes mellitus

WEDP036 Irina Tikhomirova Microcirculation and red blood cell sensitivity to nitric oxide in 2 type diabetes mellitus

WEDP037 Ingemar Fredriksson

Novel Optical Instrument for Comprehensive Microcirculation Analysis: The Relation to Cardiovascular Risk Factors

WEDP038 Akos Koller Changes in skin microcirculation in response to ischemia and heat in trained and untrained individuals

WEDP039 Ana-Maria Vintila Maximum QT interval as a predictor of atrial fibrillation in a cohort of hypertensive patients

WEDP040 Ana-Maria Vintila QTc dispersion in patients with longstanding arterial hypertension undergoing treatment for major psychiatric disorders - a case-control study

WEDP041 Lukas Streese Exercise regulates DNA methylation of p66Shc gene and improves retinal microvascular phenotype: A cross-sectional and randomized controlled trail (EXAMIN AGE)

WEDP042 Annemarie Wentzel

Heart rate variability and the dynamic nature of the retinal microvasculature: Providing insight into the brain-retina-heart link: The SABPA study

WEDP043 Annemarie Wentzel

Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: The SABPA study

WEDP044 Patricia Pia Wadowski

Sublingual microcirculation in chronic heart failure

WEDP045 Bela Zoltan Debreczeni

Differences in basal levels of microcirculation and reactive hyperemia in the forehead and forearm skin of humans

WEDP046 Junette Mohan Endothelial function in the human cutaneous microcirculation in primary open angle glaucoma.

WEDP047 Ed Eringa Effects of a hypercaloric and subsequent hypocaloric diet on insulin-induced microvascular recruitment, whole-body glucose uptake and adipose tissue lipolysis

WEDP049 Özge Erdem Unaltered Sublingual Microcirculatory Function Throughout ECMO Treatment: a Prospective Longitudinal Observational Study in Critically Ill Neonatal and Pediatric Patients

WEDP050 Neli Kachamako-va-Trojanowska

iPSC-derived Endothelial Cells With Mutation In HNF1A As Model Of Maturity Onset Diabetes Of The Young

44 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

WEDP051 Leoné Malan Stress and neurovascular coupling: A red flag? The SABPA Study

WEDP052 C. Tudorica The influence of altered hormonal pattern on the QTc dispersion in hypertensive diabetic patients

WEDP053 Eliane Wenstedt Sodium-sensitive blood pressure increase in type 1 diabetes is accompanied by impeded skin lymphangiogenesis

WEDP054 Sofia Morsing ADAM10-mediated cleavage of ICAM-1 is required for neutrophil dissociation from the endothelial surface during the final diapedesis step

WEDP055 Jamil Santos Cade NKX2.5 causes endothelial dysfunction in pulmonary arterial hypertension

WEDP056 Klaudia Schossleitner

Tight Junction Adapter Protein Cingulin Plays a Role in Vascular Barrier Function In Vivo

WEDP057 Jos Van Rijssel The GEF Trio reinforces vascular endothelial barrier integrity

WEDP058 Ana Angulo-Urarte Asymmetric endothelial adherens junctions in angiogenesis

WEDP059 Fabian Spill Mechanical Regulation of Autonomously Forming Endothelial Gaps and Cancer Extravasation

WEDP060 Justin Joachim Identification of a novel redox-sensitive kinase that controls endothelial cell permeability

WEDP061 D. Vreeken Downregulation of Endothelial PLXNA4 under Pro-atherosclerotic Conditions Diminishes Vascular Integrity Enabling Monocyte Transendothelial Migration

WEDP062 Martha Leticia Hernandez-Garcia

Development of An Ex Vivo Human Kidney Model to Study The Role of The Endothelium During Sepsis-Induced Acute Kidney Injury

WEDP063 Anna Gajos-Draus Exercise training and dietary nitrite prevent and L-NAME mimics diabetes-mediated upregulation of Nox2/NF-κB and repression of Nox4/Nrf2 in rat heart and kidney

WEDP064 Jan Nagenborg Atherosclerotic Plaque Macrophages Re-Programming Towards An Anti-Atherogenic Phenotype

WEDP065 Irina Tikhomirova The myocardial infarction milieu favours the development of protective T-cell auto-reactivity.

WEDP066 Sai Kiran Reddy Samawar

Role of Arginase II in Hypoxia-Induced Endothelial Inflammation

WEDP067 Amna Shahid Protective Effects of Exercise on Vascular Function are mediated by NADPH Oxidase 4

WEDP068 Jasper Demandt Myeloid HIF-Prolyl Hydroxylase Proteins In Human And Mouse Atherosclerosis: Triplets With Differing Characters

WEDP069 Henning Morawietz

Cigarette smoke impairs the anti-oxidative response by reducing heme levels and inducing Bach1

45ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

WEDP051 Leoné Malan Stress and neurovascular coupling: A red flag? The SABPA Study

WEDP052 C. Tudorica The influence of altered hormonal pattern on the QTc dispersion in hypertensive diabetic patients

WEDP053 Eliane Wenstedt Sodium-sensitive blood pressure increase in type 1 diabetes is accompanied by impeded skin lymphangiogenesis

WEDP054 Sofia Morsing ADAM10-mediated cleavage of ICAM-1 is required for neutrophil dissociation from the endothelial surface during the final diapedesis step

WEDP055 Jamil Santos Cade NKX2.5 causes endothelial dysfunction in pulmonary arterial hypertension

WEDP056 Klaudia Schossleitner

Tight Junction Adapter Protein Cingulin Plays a Role in Vascular Barrier Function In Vivo

WEDP057 Jos Van Rijssel The GEF Trio reinforces vascular endothelial barrier integrity

WEDP058 Ana Angulo-Urarte Asymmetric endothelial adherens junctions in angiogenesis

WEDP059 Fabian Spill Mechanical Regulation of Autonomously Forming Endothelial Gaps and Cancer Extravasation

WEDP060 Justin Joachim Identification of a novel redox-sensitive kinase that controls endothelial cell permeability

WEDP061 D. Vreeken Downregulation of Endothelial PLXNA4 under Pro-atherosclerotic Conditions Diminishes Vascular Integrity Enabling Monocyte Transendothelial Migration

WEDP062 Martha Leticia Hernandez-Garcia

Development of An Ex Vivo Human Kidney Model to Study The Role of The Endothelium During Sepsis-Induced Acute Kidney Injury

WEDP063 Anna Gajos-Draus Exercise training and dietary nitrite prevent and L-NAME mimics diabetes-mediated upregulation of Nox2/NF-κB and repression of Nox4/Nrf2 in rat heart and kidney

WEDP064 Jan Nagenborg Atherosclerotic Plaque Macrophages Re-Programming Towards An Anti-Atherogenic Phenotype

WEDP065 Irina Tikhomirova The myocardial infarction milieu favours the development of protective T-cell auto-reactivity.

WEDP066 Sai Kiran Reddy Samawar

Role of Arginase II in Hypoxia-Induced Endothelial Inflammation

WEDP067 Amna Shahid Protective Effects of Exercise on Vascular Function are mediated by NADPH Oxidase 4

WEDP068 Jasper Demandt Myeloid HIF-Prolyl Hydroxylase Proteins In Human And Mouse Atherosclerosis: Triplets With Differing Characters

WEDP069 Henning Morawietz

Cigarette smoke impairs the anti-oxidative response by reducing heme levels and inducing Bach1

WEDP070 Annemiek Dickhout CCL5 and CXCL4 are Rapidly Internalized in Endothelial Cells

WEDP071 Qiaobing Huang Polydatin ameliorates barrier function in LPS-induced endothelial injury by enhancing the activation of SIRT3

WEDP072 Neena Kalia Intravital imaging of vasculoprotective effects of haematopoietic stem / progenitor cells following myocardial ischaemia-reperfusion injury in the beating mouse heart

WEDP073 Neena Kalia Optimising the myocardial homing and therapeutic efficacy of mesenchymal stem cells using 3d culture and specific sub-populations of bone marrow-derived cells

WEDP074 Amporn Jariyapongskul

Antioxidant and Anti-inflammatory Effects of Alpha-Mangostin on Cerebral Endothelial Dysfunction and Blood Brain Barrier Leakage in Type 2 Diabetic Rats

WEDP075 Natasa Kozina The effect of high salt dietary intake and angiotensin II infusion on activity of antioxidative enzymes in serum of Sprague-Dawley rats

WEDP076 Damian Kloska Nrf2 and ageing affect the nanomechanics of the aorta: in the pursuit of possible mechanisms

WEDP077 Mauro Siragusa Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.

WEDP078 Anne Klotzsche- von Ameln

Myeloid SOCS3-deficiency regulates angiogenesis via enhanced apoptotic endothelial cell engulfment

WEDP079 Nontapat Benjathum

Effect of Naringin on Type 2 Diabetes-Induced Endothelial Dysfunction and Cognitive Impairment Correlates with AGEs/RAGE and NF-κB Inhibition

WEDP080 Ana S. Silva-Herdade

Effects of diabetes on microcirculation in non-ocular tissues: insights into hemodynamic alterations in diabetic retinopathy

WEDP081 Bram van Steen Preferred exit-sides for leukocyte diapedesis, identifying local signalling induced by ICAM-1 clustering upon leukocyte trans endothelial migration

WEDP082 Marjo Donners A disintegrin and metalloprotease adam10 controls endothelial functions in atherosclerosis

WEDP083 Carlota Saldanha Involvement of fibrinogen in the microcirculation

WEDP084 Hugo Huisman The Oxidative Stress Profile and its Relation to Vascular Function in a Bi-ethnic Cohort: the SABPA Study

WEDP085 Amber van Broekhoven

Short-term Lipopolysaccharide induces aortic valve thickening and valve hemorrhage in ApoE*3Leiden mice.

WEDP086 Hala Bagabir EFFECTS OF FAR INFRARED IRRADIATION ON VASCULAR FUNCTION IN HEALTHY SUBJECTS

WEDP087 Rio Juni Cardiac microvascular endothelial cells improve cardiomyocyte contractile function: The role of pro-inflammatory stimulation and Empagliflozin treatment

46 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

WEDP088 Pedro Felipe Malacarne

Cytochrome P450 reductase is important for endothelial function

WEDP089 Jerome Fourre Endothelial Cells Exert Stimulus-Specific Paracrine Effects on Co-Cultured Cardiomyocytes During Inflammation

WEDP090 Bernard van den Berg

Glomerular function and structural integrity depend upon endothelial hyaluronan synthesis

WEDP091 Aleksandra Kopacz S-nitrosylation-dependent protein aggregation in senescencent Nrf2-deficient endothelial cells: is there a role for ATM kinase?

WEDP092 Kwang Seok Kim A CXCR4 protects against brain vascular endothelial cells from radiation-induced senescence and damage

WEDP093 Stefano Tarantini Treatment of aged mice with the mitochondria targeted antioxidative peptide SS-31 protects against hypertension-induced cerebral microhemorrhages

WEDP094 Stefano Tarantini Endothelium-specific disruption of IGF-1 signaling impairs blood flow regulation in mice

WEDP095 Zoltan Ungvari Aging exacerbates obesity-induced cerebromicrovascular dysfunction in preclinical mouse models: novel targets for prevention of cognitive decline

WEDP096 Katrin Kalies Improving senescent endothelial cell function by partial reprogramming

WEDP097 Tamas Kiss Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

WEDP098 James Lane Docosahexaenoic Acid-derived D-Series Resolvins Direct the Regenerative Functions of Human Endothelial Colony Forming Cells

WEDP099 Michael HILL A Role for Mineralocorticoid Receptors in Vascular Smooth Muscle Cell Stiffness and Adhesion During Aging.

WEDP100 Francesca Bartoli-Leonard

SIRT1 deacetylation of p53 inhibits hyperglycaemic induced senescence in vascular smooth muscle cells

WEDP101 Ingrid Van Der Pluijm

Hybrid Optical and CT Imaging reveals increased matrix metalloprotease activity and apoptosis preceding cardiac failure in progeroid Ercc1 mice.

WEDP102 Pietro Maria Bertelli

Diabetes Induces Premature Senescence in Retinal Microvascular Endothelial Cells

WEDP103 Simin Berenji Ardestani

Endothelial function and cardiovascular stress markers in apoe knockout rats after a single simulated heliox dive

WEDP104 Sultan Al-Siyabi Prof. Sulayma Albarwani

Ageing Attenuates the Myogenic Tone of Large Coronary Arteries: Role of IP3R and L-Type Voltage-Gated Calcium Channels

WEDP105 Mieke Karel Formation of diverse occlusive arterial thrombi in a novel two-channel microfluidic system

47ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

WEDP088 Pedro Felipe Malacarne

Cytochrome P450 reductase is important for endothelial function

WEDP089 Jerome Fourre Endothelial Cells Exert Stimulus-Specific Paracrine Effects on Co-Cultured Cardiomyocytes During Inflammation

WEDP090 Bernard van den Berg

Glomerular function and structural integrity depend upon endothelial hyaluronan synthesis

WEDP091 Aleksandra Kopacz S-nitrosylation-dependent protein aggregation in senescencent Nrf2-deficient endothelial cells: is there a role for ATM kinase?

WEDP092 Kwang Seok Kim A CXCR4 protects against brain vascular endothelial cells from radiation-induced senescence and damage

WEDP093 Stefano Tarantini Treatment of aged mice with the mitochondria targeted antioxidative peptide SS-31 protects against hypertension-induced cerebral microhemorrhages

WEDP094 Stefano Tarantini Endothelium-specific disruption of IGF-1 signaling impairs blood flow regulation in mice

WEDP095 Zoltan Ungvari Aging exacerbates obesity-induced cerebromicrovascular dysfunction in preclinical mouse models: novel targets for prevention of cognitive decline

WEDP096 Katrin Kalies Improving senescent endothelial cell function by partial reprogramming

WEDP097 Tamas Kiss Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation

WEDP098 James Lane Docosahexaenoic Acid-derived D-Series Resolvins Direct the Regenerative Functions of Human Endothelial Colony Forming Cells

WEDP099 Michael HILL A Role for Mineralocorticoid Receptors in Vascular Smooth Muscle Cell Stiffness and Adhesion During Aging.

WEDP100 Francesca Bartoli-Leonard

SIRT1 deacetylation of p53 inhibits hyperglycaemic induced senescence in vascular smooth muscle cells

WEDP101 Ingrid Van Der Pluijm

Hybrid Optical and CT Imaging reveals increased matrix metalloprotease activity and apoptosis preceding cardiac failure in progeroid Ercc1 mice.

WEDP102 Pietro Maria Bertelli

Diabetes Induces Premature Senescence in Retinal Microvascular Endothelial Cells

WEDP103 Simin Berenji Ardestani

Endothelial function and cardiovascular stress markers in apoe knockout rats after a single simulated heliox dive

WEDP104 Sultan Al-Siyabi Prof. Sulayma Albarwani

Ageing Attenuates the Myogenic Tone of Large Coronary Arteries: Role of IP3R and L-Type Voltage-Gated Calcium Channels

WEDP105 Mieke Karel Formation of diverse occlusive arterial thrombi in a novel two-channel microfluidic system

WEDP106 Eszter Farkas Cerebral Microvascular Impairment Contributes to Ischemic Injury in the Aging Brain

WEDP107 Diana Sá da Bandeira

PDGFRβ Is Required in Perivascular Cells to Generate Aortic Hematopoietic Stem Cells in Vivo

WEDP108 Luís Miguel Cardoso Dos Santos

Impact of circadian rhythm in smooth muscle cells

WEDP109 Luís Miguel Cardoso Dos Santos

Smooth-muscle cell switch in atherosclerosis: a matter of intracellular S100A4?

WEDP110 Erna-Zulaikha Dayang

Identification of Lipopolysaccharide-activated Endothelial Subpopulations with Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms

WEDP112 Mohamed Essameldin Abdelgawad

Single Cell Transcriptomic Heterogeneity of Novel Markers for Human Endothelial Progenitor Cells

WEDP113 Gosia Furmanik Endoplasmic Reticulum Stress in Vascular Smooth Muscle Cells Results in Contractile Phenotype Loss and Regulates Calcification Mediated by Grp78-Loaded Extracellular Vesicles

WEDP114 Antonija Sakic S100A4, a key player in plaque stabilization.

WEDP115 Carmen Ciavarella Endothelial-mesenchymal transition represents a key process during atherosclerotic plaque calcification

WEDP116 Matthew Lee Heterogeneity Enables Parallel Processing of Multiple Stimuli in the Intact Vascular Endothelium

48 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Industry Sponsored SymposiaTuesday April 16th 2019 from 13:00-14:00

Title: Microvascular High-tech solutions from bench to bed Physical vascular therapy

SPONSORED BY Bemer Int. AG Ralph Burger, Bemer, LIE (chair) & Joshua Berka, Bemer, USA (chair)

Session room : 0.4/0.5 Brussels/Paris

13:00 Fluorescence imaging procedure for lymphatic surgery, C. Täger (Germany)

13:15 Physical vascular therapy affects heart rate and heart rate asymmetry in patients with coronary heart disease, L. Hejjel (Hungary)

13:30 Observations and experiences in the application of a therapy blanket by induction of electromagnetic force on the tissue of horses, H.J. Genn (Germany)

13:45 Physical Vascular Therapy: Clinical Interventions and Preventative Medicine, J. Berka, NMD (USA)

Wednesday April 17th 2019 from 13:00-14:00

Title: Retinal Vessel Analysis – applied physiology and clinical application SPONSORED BY Imedos Systems GmbH Henner Hanssen Basel, CHE (chair) & Doreen Schmidl Vienna, AUT (chair)

Session room : 0.4/0.5 Brussels/Paris

13:00 Retinal Vessel Analysis: a biomarker of cardiovascular risk, Henner Hanssen (Basel, CH)

13:15 Retinal microvascular dysfunction in heart disease, Andreas Flammer (Zurich, CH)

13:30 Retinal vessel imaging: predictor for mortality in end stage renal disease – TheISAR study, Christoph Schmaderer (Munich, DE)

13:45 Microvascular dysfunction in obesity and diabetes: causes, consequences and actions, Boy Houben (Maastricht, NL)

Wednesday April 17th 2019 from 13:00-13:30

Title: Deoxyhemoglobin vasodilator

SPONSORED BY Circularity Healthcare

Session room : 2.1 Colorado

13:00 Efficacy of Transdermal CO2 Administration Using a Deoxyhemoglobin Vasodilator Medical Device to Treat Diabetic Foot Ulcers

Ito Puruhito (Airlangga University Medical Faculty, Indonesia)

49ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Our Sponsors/Exhibitors/Partners

Imedos Systems GmbH Booth L0.02

The microcirculation of the retina is an excellent window to the heart and the brain. Retinal vessels offer the unique opportunity to be examined in vivo and non-invasively and to provide valuable information about the condition of the body’s microcirculation.

Imedos is using these characteristics of the ocular transparency to analyse retinal arteries and veins. For more than 20 years we are committed to retinal microcirculation by developing and manufacturing systems to determine biomarkers of microvascular health.

Learn more about the possibilities of Imedos products and their scope for your microvascular research. Visit us at our booth at ESM&EVBO conference 2019 and join us at the Lunch Symposium “Retinal Vessel Analysis – applied physiology and clinical application” (Wednesday April 17th 2019 from 1-2 p.m.).

BEMER Int. AG Booth L0.01

The BEMER Int. AG was founded in 1998 and is an international company within the healthcare industry. The company based in Triesen / Liechtenstein is a medically-certified technology developer and inventor of the “BEMER® Physical Vascular Therapy”.

The core competence of the company is the research and development of high-tech solutions for the physical therapy of microcirculation disorders. The devices have been developed for daily use in the professional field as well as for private home users.

The BEMER Int. AG offers devices in the medical and veterinary fields.

Platinum Sponsors

The organizers of ESM-EVBO 2019 Maastricht greatly appreciate the kind support of all sponsors, exhibitors, and partners, in making this conference a great success!

50 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Imedos Systems GmbH | Am Nasstal 4 | 07751 JenaTel +49 (0) 36 41 63 96-0 | www.imedos.de

Technology for Microvascular Health Dynamic Vessel Analyzer DVA 3.0

…the third generation

to assess the

retinal microvascular

(dys-)function

51ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

20 Years leading Solutions for Microcirculation

Physical vascular therapy BEMER®

Microvascular High-tech solutions from bench to bed

Tuesday April 16, Room Brussels/Paris 1-2 p.m.

Sponsored Lunch Symposium BEMER

Visit us at Booth #L0.01 i.e. Level 0, Booth 1!

More Health. More Life.

www.bemergroup.com

52 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Exemplar Genetics Booth L1.00

Exemplar Genetics is the leading provider of genetically engineered MiniSwine research models of human disease. ExeGen® MiniSwine models allow researchers to study both safety and efficacy simultaneously with improved translational outcomes. The ExeGen® models assist in enabling discovery of human disease mechanisms, the optimization of novel diagnostics, and the development of new treatments by more accurately replicating human disease symptoms. Eighteen models are available today including cardiovascular, cancer, cystic fibrosis, renal, arrhythmia, neurodegenerative and other rare diseases. Exemplar Genetics additionally offers a custom model program and assists with the characterization of disease phenotype.

Sanofi

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.

With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.

Sanofi, Empowering Life

Bronze Sponsors

FujiFilm VisualSonics Booth L1.02

ibidi – cells in focus Booth L1.01

Circularity Healthcare, LLC

Silver Sponsors

53ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Follow us on Twitter: @ExeGenMiniSwine

Phone: 001-712-722-2767Email: [email protected]

2018 Vascular Biology Ad.indd 1 2018-08-29 11:14:04 AM

Learn more at our booth!

Booth #L1.00

Booth #L1.02

54 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Discover the finest products for tissue blood flow and oxygen assessments

with global customer service to match

www.moor.co.uk

innovation in microvascular assessment

Booth L1.04

ibidi GmbH | +49 89 / 520 46 17 - 0 | [email protected] .com

Tube Formation Assays3 Reasons to Use the µ-Slide Angiogenesis

• Low Matrigel volume

• No meniscus

• High optical quality

Free samples at: ibidi.com

Booth L1.01

Booth L1.06

Booth L1.15

Booth L1.10Booth L1.05

Booth L1.07

55ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

The Tissue Viability Imager (TiVi) is polarization spectroscopy camera system that can see beyond the top layer of the skin and collect

information about the underlying microcirculation and other skin parameters. TiVi700 is the most sophisticated version of the TiVi

technology designed for demanding research applications. TiVi8000 is a simplified hand-held model intended for rapid screening of skin irritation and damage both in the laboratory

and at the worksite. TiVi9000 displays and objectively quantifies real time dynamic alterations in oral mucosa

microcirculation.

Automated FMD Robotic arm Operator independent

www.alf-distribution.com

A source of current research, new methods and state-of-the-art reviews in vascular biology and microcirculation

The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation.

Editor-in-Chief

U. Pohl Munich

www.karger.com/jvr KI19

143

Booth L1.12Booth L1.13

Stone SponsorsGreiner Bio-One B.V.IOP PublishingKK TechnologyLEA Medizintechnik GmbHLonzaMIMETASMoor Instruments

PetroTechPerimed ABtubu-bioUNEX CorporationVascular BiologyWheelsbridge AB

56 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Partners

57ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Notes

58 ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

Level 0Booth L0.01 Bemer Int. AGBooth L0.02 Imedos Systems GmbH

Level 1Booth L1.00 Exemplar GeneticsBooth L1.01 ibidi – cells in focusBooth L1.02 FujiFilm VisualSonicsBooth L1.03 tebu-bioBooth L1.04 Vascular BiologyBooth L1.05 Moor InstrumentsBooth L1.06 KK Technology

Level 1 Booth L1.07 PeproTech Booth L1.08 Perimed ABBooth L1.09 IOP PublishingBooth L1.10 MIMETASBooth L1.11 LEA Medizintechnik GmbHBooth L1.12 WheelsBridge AB.Booth L1.13 UNEX Corporation Booth L1.14 Lonza Booth L1.15 Greiner Bio-One B.V.

Exhibitor Floor plan and Legend

Poort 20

Poort 19

0.11Perscentrum

L

E.E.

E.E.

E.E.E.E.

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Trajectum

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0.4Brussels

0.5 Paris

0.3Copenhagen

0.2 Berlin

0.7Lisbon

0.6Madrid

0.1London

0.9Athens

0.8Rome

#L0.02

#L0.01

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P015 - P028

P029 - P032

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ESM - EVBO 2019Floorplan Lobby

Version: 26-03-2019W

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59ESM-EVBO 2019, MAASTRICHT, THE NETHERLANDSESM-EVBO 2019, MAASTRICHT, THE NETHERLANDS

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P070-

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P103 - P109

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Schaal 1:250WIJZIGINGEN VOORBEHOUDEN / CHANGES EXCEPTED

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MECC Level 2

Thank You to our Sponsors/ Exhibitors and Partners

PLATINUM

innovation in microvascular assessment

SILVER

BRONZE

EXHIBITORS

PARTNERS European Society for Microcirculation (ESM)

European Vascular Biology Organization (EVBO)Cardiovascular Research (CVR)

Amsterdam Cardiovascular Sciences (VUmc)Dutch Society for Microcirculation

Dutch heart foundation / Hartstichting

University of Limburg (SWOL)CARIM (Universiteit Maastricht)

Gesellschaft für Mikrozirkulation und Vaskuläre BiologieJVR Journal of Vascular Research

ESC Working Group Atherosclerosis & Vascular BiologyServier