For more information about the products featured in this brochure click on the product name

Click on the name of a Click on the name of a company to visit their website

MicroMountstradeMicroMountstrade are the highest performance tools for manipulating and mounting protein crystals virus crystals and small moleculeinorganic crystals as well as a wide range of other small fragile samples They are ideal for both conventional and high-throughput X-ray crystallography applications

MicroMeshtrade MountsMicroMeshtrade Mounts are the tool of choice for microcrystal crystallography and diffraction experiments especially at microfocus beamlines They are excellent for rod shaped crystals and in particular are superior to mounts with elliptical apertures because the mesh provides continuous gentle support for rods of all sizes

Enabling TechnologyA new approach to crystal mounting handling and X-ray data collection based on microfabricated polyimide thin films This patented design provides an excellent combination of X-ray and optical transparency mechanical rigidity and flexibility and precision dimensions

Patents US 7263162 US 7542546 US 7666259 2004233143 (AU) CN 101080628B (CN) 6020040390224 (DE) 1623202 (FR GB CH) 170954 (IL)

Inventors Viatcheslav Berejnov Yevgeniy Kalinin Jan Kmetko Kevin OrsquoNeill Zachary Stum amp Robert Thorne

Licensee MiTeGen LLC

copyMiTeGen LLC

MicroToolstradeThese tools are designed for use with samples from a few micrometers to a millimeter in size MicroToolstrade have tips made from soft flexible microfabricated polymer films The curvature of the tips gives them rigidity but they can still easily be flexed to eg slide flat along the well bottom in a multiwell plate simplifying sample retrieval These tools are far less likely to damage fragile samples than metal microtools and are optically and X-ray transparent

Enabling TechnologyA method for manipulating and mounting crystals for X-ray crystallography and structure determination consisting of a microfabricated plastic film attached to a cylindrical post

Macromolecular crystals are extremely fragile and are easily destroyed by incidental contact with hard objects They often adhere to the glass slides or containers in which they are grown and are difficult to remove to use in X-ray diffraction studies

Patent US 8210057 | Inventors Guanhan Chew amp Robert Thorne

Licensee MiTeGen LLC

copyMiTeGen LLC

MicroMountstradeMicroMountstrade are the highest performance tools for manipulating and mounting protein crystals virus crystals and small moleculeinorganic crystals as well as a wide range of other small fragile samples They are ideal for both conventional and high-throughput X-ray crystallography applications

MicroMeshtrade MountsMicroMeshtrade Mounts are the tool of choice for microcrystal crystallography and diffraction experiments especially at microfocus beamlines They are excellent for rod shaped crystals and in particular are superior to mounts with elliptical apertures because the mesh provides continuous gentle support for rods of all sizes

Enabling TechnologyA new approach to crystal mounting handling and X-ray data collection based on microfabricated polyimide thin films This patented design provides an excellent combination of X-ray and optical transparency mechanical rigidity and flexibility and precision dimensions

Patents US 7263162 US 7542546 US 7666259 2004233143 (AU) CN 101080628B (CN) 6020040390224 (DE) 1623202 (FR GB CH) 170954 (IL)

Inventors Viatcheslav Berejnov Yevgeniy Kalinin Jan Kmetko Kevin OrsquoNeill Zachary Stum amp Robert Thorne

Licensee MiTeGen LLC

copyMiTeGen LLC

MicroToolstradeThese tools are designed for use with samples from a few micrometers to a millimeter in size MicroToolstrade have tips made from soft flexible microfabricated polymer films The curvature of the tips gives them rigidity but they can still easily be flexed to eg slide flat along the well bottom in a multiwell plate simplifying sample retrieval These tools are far less likely to damage fragile samples than metal microtools and are optically and X-ray transparent

Enabling TechnologyA method for manipulating and mounting crystals for X-ray crystallography and structure determination consisting of a microfabricated plastic film attached to a cylindrical post

Macromolecular crystals are extremely fragile and are easily destroyed by incidental contact with hard objects They often adhere to the glass slides or containers in which they are grown and are difficult to remove to use in X-ray diffraction studies

Patent US 8210057 | Inventors Guanhan Chew amp Robert Thorne

Licensee MiTeGen LLC

copyMiTeGen LLC

RAS Activation AssayThe assay uses the Ras-binding domain (RBD) of the Ras effector kinase Raf1 The Raf-RBD domain has been shown to bind specifically to the GTP-bound form of Ras proteins The assay provides a simple means of quantitating Ras activation in cells

Enabling TechnologyThe assay involves immobilizing a wild type or recombinant effector protein or binding domain on a solid support incubating the effector with cell lysates and determining the amount of bound Ras with antibodies

Inventors David Shalloway amp Stephen Taylor

Licensees Active Motif Inc Cytoskeleton Inc EMD Millipore Corporation

Alstroemeria lsquoMauve MajestyrsquoAlstroemeria lsquoMauve Majestyrsquo produces gorgeous mauve to rose pink flowers accented by dark speckling and creamy yellow throat This variety is native to South America and flowers May through frost lsquoMauve Majestyrsquo performs best in well-drained humus-rich soil under full sunlight Uniform soil temperatures extend bloom period

Enabling TechnologylsquoMauve Majestyrsquo is a cultivar of Alstroemeria with mauve colored flowers It has vigorous growth and cold tolerance (to USDA zone 5)

Patent PP18183 | Inventor Mark Bridgen

Licensees Edelweiss Perennials Garden Crossings LLC North Creek Nurseries Inc Sunny Border Nurseries

Alstroemeria lsquoTangerine TangorsquoAn absolutely vibrant array of tangerine colored flowers blanket sturdy upright stems from May until first frost A creamy yellow throat and deep speckling accentuate flowers

Enabling TechnologyAlstroemeria lsquoTangerine Tangorsquo is a winter-hardy Inca Lily that is native to Chile and can bloom continuously throughout the season until frost It has cold tolerance (to USDA zone 5)

Patent PP22701 | Inventor Mark Bridgen

Licensee North Creek Nurseries Inc

AMTSCATTLEPROAMTSCATTLEPRO is software developed for the professional nutritionist to efficiently formulate the best diets possible for their cattle It is designed for advanced field nutritionists or technical nutritionists who can use PRO to formulate rations or to support field nutritionistsrsquo files

Licensee Agricultural Modeling and Training Systems LLC Dalex

Livestock Solutions LLC amp RUMampN Sas

NDS ProfessionalNDS Professional is a computer platform designed to support field nutritionists helping them with nutrition management and ldquoon-siterdquo decision making It is characterized by an easy to use interface allowing users to minimize the inputs required and simplify all data entry

Licensee Dalex Livestock Solutions LLC RUMampN Sas

Enabling TechnologyRuminants are utilized to convert feed nutrients to human food under widely varying conditions around the world and are a major source of human food nutrients The goals of improving ruminant nutrition are to improve productivity reduce resource use and protect the environment The technology can predict requirements feed utilization animal performance and nutrient excretion for dairy and beef cattle and sheep using accumulated knowledge about feed composition digestion and metabolism in supplying nutrients to meet requirements

Inventors Larry Chase Danny Fox Thomas Overton Alice Pell Ronald Pitt Charles Sniffen Luis Tedeschi Tom Tylutki Michael Van Amburgh

amp Peter Van Soest

Apple lsquoFortunersquolsquoFortunersquo is a large attractive apple that ripens in early September The lsquoFortunersquo tree has dense foliage and is very vigorous lsquoFortunersquo has an excellent crisp flavor and is good for quality fresh eating It is suitable for fresh roadside and processed markets

Enabling TechnologylsquoFortunersquo a hybrid of lsquoEmpirersquo by lsquoSchoharie Spyrsquo combines the desirable attributes of its parents It combines the favorable processing characteristics of lsquoSpyrsquo with large size and good coloring similar to lsquoEmpirersquo It appears to be widely adapted to growing regions throughout the United States

Patent PP11000 | Inventors Susan Brown David Terry amp Roger Way

Licensees Adams County Nursery Cummins Nursery Flemingrsquos Nurseries amp Associates Pty Ltd Pepiniere Rochon Inc Schlabach Nursery Wafler Nurseries

Apple Royal Empirereg

Royal Empirereg is a McIntosh type apple with better color and flavor longer shelf life and refrigerated keeping ability It is a medium size round firm quality dessert apple that is also good for cider

Enabling TechnologyRoyal Empirereg produces fruit significantly brighter and redder than its parent This color distinction allows for a higher proportion of the fruit to qualify for extra fancy grade

Inventors Harold Teeple John Teeple amp Russell Teeple

Licensees Cummins Nursery Flemingrsquos Nurseries amp Associates Pty Ltd Stark Brothers Nursery

Apple Rootstock GENEVAreg lsquoG11rsquoGENEVAreg lsquoG11rsquo is a 1978 cross of lsquoM-26rsquo and lsquoRobusta 5rsquo crabapple With high fruit efficiency and large fruit size this rootstock works well in many commercial orchards and replant sites

Apple Rootstock GENEVAreg lsquoG16rsquoGENEVAreg lsquoG16rsquo is a 1981 cross of lsquoOttawa 3rsquo and lsquoMalus floribundarsquo In the orchard GENEVAreg lsquoG16rsquo is non-brittle and well-anchored

Apple Rootstock GENEVAreg lsquoG30rsquoGENEVAreg lsquoG30rsquo originated from a cross of lsquoRobusta 5rsquo and lsquoM-9rsquo GENEVAreg lsquoG30rsquo apples show to be winter hardy with extremely high yield efficiency GENEVAreg lsquoG30rsquo is resistant to fire blight and is broadly adaptable to soil conditions

Enabling TechnologyThese rootstocks were developed with an emphasis on ease of nursery propagation fireblight resistance tolerance to extreme temperatures resistance to soil pathogens and tolerance to apple replant disorder

Patents PP12443 PP11070 PBR20406 (Europe) | Inventors Herb Aldwinckle James Cummins Philip Forsline David Gill amp Terence Robinson

Licensees Cameron Nursery LLC Consorcio Viveros Sacramento Copenhaven Farms Cummins Nursery Europa Fruit Tree Rootstock North American Plants Inc Helios Nurser Kit Johnston Farms Treco Inc Uni-Viveros Wafler Nurseries Willamette Nursery Inc Willow Drive Nursery Inc

AppleboosttradeA diet rich in plant foods has been suggested to reduce the risk of cancer diabetes heart disease and many other lifestyle-related diseases Like all plant foods apples - especially the peels - contain naturally occurring nutrients that have potent antioxidant and anti-inflammatory activity AppleBoosttrade is packaged with no chemical alterations just 100 organic dried apple peel powder

Enabling TechnologyIn apples many of the beneficial phytochemicals are found in the peel up to six times more than in the apple flesh Apple peel powder with high antioxidant activity can be made from left over apple peels used to make processed products such as applesauce Peels are generally considered waste and are discarded without other purposes

Patent 8551554 | Inventors Rui Hai Liu amp Kelly Wolfe

Licensee Leahy Orchards Inc

Cherry lsquoRoyaltonrsquolsquoRoyaltonrsquo is a dark purple-red cherry It has excellent flavor and is crack-resistant lsquoRoyaltonrsquo is a standout at cherry blossom time and when the fruit ripens in mid-June lsquoRoyaltonrsquo can be used as a pollinator for other sweet cherries

Enabling TechnologyThe lsquoRoyaltonrsquo cherry is sweet with exceptionally large and high quality fruit The upright and vigorous tree yields crack tolerant firm fruit

Patent PP11107 | Inventors Robert Andersen Susan Brown David Terry amp Roger Way

Licensees Adams County Nursery Boyer Nurseries amp Orchards Inc Cummins Nursery Flemingrsquos Nurseries amp Associates Pty Ltd ProTree Nurseries Stark Brothers Nursery Wafler Nurseries

Cherry lsquoHartlandrsquolsquoHartlandrsquo is a sweet cherry ideal for the processed and fresh markets and uniquely suited as a pollinizer in commercial orchards This fruit is deep red-purple of medium size with consistently heavy crops

Enabling TechnologylsquoHartlandrsquo is sweet firm and medium in size lsquoHartlandrsquosrsquo sugar levels are lower than many commercial cultivars but taste is consistently rated high It is an early mid-season producer with a winter hardy disease tolerant tree

Patent PP11034 | Inventors Robert Andersen Susan Brown David Terry amp Roger Way

Licensees Adams County Nursery Australian Nurserymenrsquos Fruit Improvement Company Cummins Nursery Flemingrsquos Nurseries amp Associates Pty Ltd Raintree Nursery Wafler Nurseries

Buddleia Flutterby GrandetradeThe Buddleia Flutterby Grandetrade series grows to be 72-96rdquo tall by 48-72rdquo wide The plants grow upright and tend to be dense They bloom from early summer to frost and are drought and heat tolerant

Buddleia FlutterbytradeThe Buddleia Flutterbytrade series grows to be 48-60rdquo tall by 48-60rdquo wide The plants have dense growth habit and bloom from early summer until frost The flowers attract hummingbirds and butterflies They are drought and heat tolerant

Buddleia Flutterby PetitetradeThe Buddleia Flutterby Petitetrade series grows to be 24-30rdquo tall by 24-30rdquo wide The plants need full sun and are adaptable to a wide range of soil types and growing conditions They bloom from early summer until frost

Buddleia Flutterby FlowtradeThe Buddleia Flutterby Flowtrade series grows to be 18-24rdquo tall by 36-48rdquo wide The flowers cover the plant blooming from late spring until frost They are easy to grow and require low maintenance

Enabling TechnologyBuddleia commonly known as ldquoButterfly Bushrdquo is a popular garden shrub that attracts butterflies bees and hummingbirds with their strongly-scented flower heads While Buddleia may be considered an invasive species and can grow into dense thickets these plants are sterile selections In addition to taming invasiveness the breeders have expanded Buddleias typical flower color range to include reds and oranges They have also increased the flower size by more than three fold Some lines are suitable for compact habits or container cultures

Patents PP22066 PP22068 PP22065 PP22069 PP22067 PP22080 PP22081 PP22098 PP22110 PP22108 PP22109 PP22144 PP22143 PP22142

PP22177 PP22367 | Inventor Peter Podaras

Licensee Ball Horticultural Company

Cherry lsquoSomersetrsquolsquoSomersetrsquo is a dark red heart shaped cherry The tree is unique because it bears crops early in the life of new orchards Trees have moderate vigor so less pruning and training time is required

Enabling TechnologylsquoSomersetrsquo is a sweet black cherry with exceptional crispness As a result of lsquoSomersetrsquosrsquo remarkable firmness it has a much longer shelf-life for fresh sales than most other sweet cherries

Patent PP11118 | Inventors Robert Andersen Susan Brown David Terry amp Roger Way

Licensees Adams County Nursery Australian Nurserymenrsquos Fruit Improvement Company Cummins Nursery Flemingrsquos Nurseries amp Associates Pty Ltd Wafler Nurseries

Cherry lsquoSurefirersquo lsquoSurefirersquo is a tart cherry with firm bright skin flesh and juice that make it excellent for processing It has late white flower blossoms so frost danger is low and it is crack resistant USDA cold hardiness zones 4-8

Enabling TechnologylsquoSurefirersquo has the ability to evade and tolerate frosts due to late bloom time The bright fire engine red skin and flesh combined with its naturally high sugar content make it an excellent choice to market for fresh eating

Patent PP11108 | Inventors Robert Andersen Susan Brown David Terry amp Roger Way

Licensees Adams County Nursery Cummins Nursery Flemingrsquos Nurseries amp Associates Pty Ltd Raintree Nursery Stark Brothers Nursery

CU-Structural Soilreg

CU-Structural Soilreg is an urban tree mix that can safely support pavements and sidewalks It is designed to provide ample rooting area for street trees leading to increased tree growth and decreased tree mortality and sidewalk failure

Enabling TechnologyTree roots are associated with sidewalk failure The failure is usually due to tree roots growing directly under the sidewalk surface since conditions such as moisture and air are most favorable for root growth Ordinary soil is too easily compacted and as a result does not sustain deep root growth away from the sidewalk surface

This technology is a stone-soil hydrogel mixture which supports pavements yet allows tree roots to grow freely The mix withstands the compaction necessary to provide pavement stability for sidewalks and planting locations next to city roads and pedestrian malls while allowing urban tree growth and vigor

Patent US 5849069 | Inventors Nina Bassuk amp Jason Grabosky

Licensee Amereq Inc

Cucumber lsquoGreen FingerrsquolsquoGreen Fingerrsquo is a slicing cucumber with fruit that average 8-10 inches with a thin skin exceptional flavor and a small seed cavity It has more durability than most varieties of this type and stores just as well as American slicers without needing to be wrapped

Enabling TechnologyThis cucumber shows excellent disease resistance to powdery mildew papaya ring spot virus watermelon mosaic virus zucchini yellow mosaic virus and high tolerance to angular leaf spot It matures in sixty days

Inventors Mark Henning Margaret Jahn amp George Moriarty

Licensee High Mowing Organic Seeds Inc

Inventors Margaret Jahn amp Henry Munger

Licensees Emerald Seed Company Magnum Seeds Inc Territorial Seed Company

Cucumber lsquoMarketmore 97rsquolsquoMarketmorersquo is a bitter-free slicing cucumber lsquoMarketmorersquo is a northern cultivar that can be 9-11 inches straight It matures in fifty-five days

Enabling TechnologyThis cucumber is also one of the most disease resistant varieties on the market due to its resistance to cucumber mosaic virus powdery mildew downy mildew and scab

Grape lsquoChardonelrsquolsquoChardonelrsquo makes an inexpensive crisp dry wine with undertones of cream and butter and a slightly floral fruity nose

Enabling TechnologylsquoChardonelrsquo is a cross between lsquoChardonnayrsquo and lsquoSeyval blancrsquo The lsquoChardonelrsquo grape variety offers high productivity and superior cold hardiness

Inventors Robert Pool amp Bruce Reisch

Licensees Flemingrsquos Nurseries amp Associates Pty Ltd

Grape lsquoMarquisrsquolsquoMarquisrsquo is a vigorous white seedless grape This high flavor grape is an excellent table grape and also produces pleasant and delicate white wine

Enabling TechnologyThe lsquoMarquisrsquo grape resulted from the cross of lsquoAthensrsquo with lsquoEmerald Seedlessrsquo It is a mid-season white seedless grape Vines are moderately cold-hardy medium in vigor and productive

Patent PP11012 | Inventors Robert Pool amp Bruce Reisch

Licensees Cummins Nursery Double A Vineyards E J Gallo Winery Flemingrsquos Nurseries amp Associates Pty Ltd Meyer Nursery amp Orchards Inc Northwoods Nursery Piedmontese Nursery amp Vineyard Silver Creek Vineyard amp Nursery Turnbull Nursery Whitman Farms

Grape lsquoNoiretrsquolsquoNoiretrsquo vines are vigorous and productive in the Finger Lakes region of New York lsquoNoiretrsquo represents a distinct improvement in the red wine varietal options available to cold climate grape growers

Enabling TechnologyA mid-season red wine grape suitable for the production of varietal wines lsquoNoiretrsquo produces notes of green and black pepper along with raspberry blackberry and some mint aromas A major distinguishing characteristic of this selection is the fine tannin structure complete from the front of the mouth to the back The vine is moderately winter hardy and resistant to powdery mildew and botrytis bunch rot

Inventor Bruce Reisch

Licensees Double A Vineyards Grafted Grapevine Nursery Red Dog Vineyards and Nursery Silver Creek Vineyard amp Nursery Vintage Nurseries

Grape lsquoValvin MuscatrsquolsquoValvin Muscatrsquo is recommended for the production of high quality Muscat wines and is useful as a varietal wine and for blending to add flavor and aroma to table wines It provides consistently high quality semi-dry wine with spicy floral Muscat aromas and no bitterness

Enabling TechnologyA hybrid grape resulting from a cross of lsquoMuscat du Moulinrsquo and lsquoMuscat Ottonelrsquo lsquoValvin Muscatrsquo is moderately winter hardy and well-suited to good grape growing sites in the eastern US

Inventor Bruce Reisch

Licensees Double A Vineyards Grafted Grapevine Nursery Silver Creek Vineyard amp Nursery Vintage Nurseries

Melon lsquoPMR Delicious 51rsquolsquoPMR Delicious 51rsquo ripens quickly resulting in heavy top quality yields The melons average 2-3 pounds It is a netted cantaloupe that is juicy with sweet dark orange aromatic flesh

Enabling TechnologylsquoPMR Delicious 51rsquo has an excellent resistance to powdery mildew and Fusarium wilt (race 1) It matures in seventy-five days

LFS Test Testing is easy and highly accurate and can be performed at any point in time in the life of the animal with pulled hair whole blood in EDTA or bristle style cheek swaps All breeding animals should be tested to avoid major losses and heartache for owners and to prevent morbidity in the animals

Enabling TechnologyLavender Foal Syndrome (LFS) is a genetic disorder with neurological features thought to be caused by a brain lesion This disorder is usually associated with Arabian horses although it has been reported in other breeds In addition to a difficult birth affected foals often have a diluted coat color that can appear pale lavender As affected foals are usually euthanized within days of birth this technology offers for the first time the ability detect the mutation associated with LFS to diagnose both the condition and to guide breeding practices so as to prevent its continuation in bloodlines via carriers

Patent 8932810 | Inventors Douglas Antczak amp Samantha Brooks

Licensees Cornell AHDC UC Davis Veterinary Medicine VetGen LLC

ISCAlure-TutaISCAlure-Tuta is a pheromone-based lure product for South American tomato leafminer Tuta absoluta that attracts and traps the insect The lure is loaded into a lure dispenser to protect the pheromone compounds from the elements and modulate the release of the pheromone with a release rate mimicking that of the leafminer (moth)

Enabling TechnologyScrobipalpuloides moth is a serious pest of tomato plants with losses up to 100 reported Since no attractant for this pest has previously existed control now requires blanket-spraying of insecticides Four key problems have been associated with this constant use of conventional insecticides to control insect pests pesticide residue on food increased pesticide resistance detrimental effect on beneficial insects and economical inefficiency This product is highly effective at attracting insects without using pesticides The invention includes the chemical compounds blends synthesis methods moth traps and method for mating description

Inventors Mark Henning Margaret Jahn amp Henry Munger

Licensee High Mowing Organic Seeds Inc

copyISCA Technologies Inc

Patent US 5728376 | Inventor Athula Attygalle

Licensee ISCA Technologies Inc

Messengerreg and Employreg

Product series for foliar spray that reduces transplant shock enhances crop growth quality and yield increases plant stamina and vigor and suppresses nematode egg production They are used on vegetables flowers turf trees and landscape plants

ProActTM

ProActTM is a foliar spray product for reducing nematode populations improving overall plant health and yield ProActTM is the only foliar spray product labeled for use against nematodes in corn and soybeans

N-Hibitreg and AcceleroNTM

Product series in seed treatment that suppresses nematode egg production increases root mass plant stamina and vigor and enhances crop yield They are used for field crops such as corn cotton soybean and canola and other vegetable cucurbit and cole crops

Enabling TechnologyThe underline proprietary ldquoHarp-N-Tekrdquo technology for these products is based on the Harpin technology originated from Cornell Harpin proteins are produced in nature by certain bacterial plant pathogens Many of the plants that those pathogens attack have developed receptors on their seeds roots and foliage to detect the presence of Harpin Proteins which are used as triggers to activate certain defensive and growth responses Mimicking nature the Harp-N-Tek seed treatments or foliar regulators will turn on stress-defense and growth systems in the plants that result in improved crop vigor stamina nutrient uptake and reproductive growth

Patents US 5776889 US 5849868 US 5858786 US 5859324 US 6001959 US 6174717 US 6583107 US 6855683 US 6998515 US 7029667 US 7045123 748088 (AU) 750732 (AU) PI19816222-5

(BR) 2223616 (CA) 2279550 (CA) ZL 971816697 (CN) ZL961961465 (CN) ZL988036541 (CN) ES2248810T3 (ES) 1012255 (FR DE IT NL ES GB) 648266 (FR IT NL ES GB) 702694 (FR GB DE ES) 871354 (FR DE LI NL GB) 1357189 (GB BE FR DE GR IT NL PT ES) 20050402628 (GR) 3961023 (JP) 4571240 (JP) 5103446 (JP) 529261 (KR) 529268 (KR)

234658 (MX) 247918 (MX) 336041 (NZ) 336892 (NZ)Inventors James Alfano David Bauer Steven Beer Adam Bogdanove

Amy Charkowski Alan Collmer Jong Hyun Ham Sheng-Yang He Jihyun Kim Ron Laby Dewen Qiu Adela Ramos Zhongmin Wei amp Thomas Zitter

Licensee Plant Health Care Inc

OptiPhosreg

OptiPhosreg is a feed additive that contains phytase which releases phosphorous from vegetable raw materials OptiPhosreg releases more phosphorous from feed grain in poultry and swine than any other phytase product This results in an enhanced diet for the animal as inorganic phosphate is replaced by energy In addition OptiPhosreg benefits the environment as substantially less phosphorus is released onto the land

Enabling TechnologyThe product is based on Ecoli phytase produced in the expression system of yeast Pichia pastoris Ecoli phytase is a new generation of phytase for feed additive with faster mode of action and better functions at pH levels common in the upper digestive tract

Patent US 6511699 US 6841370 US 6974690 US 7300781 US 7829318 772071 (AU) 2365418 (CA) ZL008081417 (CH)

ZL998098930 (CH) 301 680 (CZ) 1090129 (DN FR DE IT NL ES GB) 1165806 (DN FR DE GB IT NL) ES2248067T3 (ES) 790918 (KR) 232332

(MX) 257585 (MX) | Inventor Xingen Lei

Licensee Phytex LLC

PARP-1 Terminal AntibodyThis PARP-1 terminal antibody has been validated for use in Western blotting chromatin IP and works in immunohistochemistry and immunoprecipitation

Enabling TechnologyPolyclonal antibodies against the N-terminal of PARP-1 Poly [ADP-ribose] polymerase 1 a chromatin-associated enzyme that modifies various nuclear proteins The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation proliferation and tumor transformation

Inventors Mi Young Kim amp William Kraus

Licensee Active Motif Inc

Pepper lsquoKing CrimsonrsquolsquoKing Crimsonrsquosrsquo early peppers are uniformly medium-sized and blocky with four lobes and thick walls The green peppers mature in sixty days and the red peppers mature in seventy days

Enabling TechnologylsquoKing Crimsonrsquo shows intermediate resistance to cucumber mosaic virus

Inventors Michael Glos Margaret Jahn amp George Moriarty

Licensee High Mowing Organic Seeds Inc

Pepper lsquoPeaceworkrsquolsquoPeaceworkrsquo is a sweet early red bell pepper with medium-thick walls The peppers have good flavor and full-bodied sweetness

Enabling TechnologylsquoPeaceworkrsquo is a stabilized open-pollinated variety with lsquoKing of the Northrsquo and lsquoEarly Red Sweetrsquo in its parentage

Inventors Michael Glos Margaret Jahn amp George Moriarty

Licensee Fedco Seeds Inc

Potato lsquoMarcyrsquolsquoMarcyrsquo has a round to oval shape shallow eyes and scab resistance suitable for tablestock lsquoMarcyrsquo is also an excellent choice for a chipping variety

Enabling TechnologylsquoMarcyrsquo potato is a cross between lsquoAtlanticrsquo and lsquoQ155-3rsquo lsquoMarcyrsquo is a late maturity chipstock lsquoMarcyrsquo has outstanding yield of large tubers lsquoMarcyrsquo is resistant to golden nematode and scab

Patents PVP200200121 PBR3469 (CA) | Inventors Walter De Jongamp Robert Plaisted

Licensees Bartlett Farms Childstock Farms Inc Daniel J Corey and Entities Hemphill Farms Inc Maine Seed Potato Board M Skonieczny amp Son Inc Rine Ridge Farms Inc Skye View Farms Ltd

Potato lsquoPikersquolsquoPikersquo is a white skin white flesh potato It has mid-sized tubers and makes a good chipping potato

Enabling TechnologylsquoPikersquo potato has excellent common scab resistance and is also resistant to golden nematode lsquoPikersquo matures in mid to main season

Patents PBR 10447 (Europe) PBR 0565 (CA) | Inventor Robert Plaisted

Licensee Fulton Hamill Ltd

Potato lsquoRed MariarsquolsquoRed Mariarsquo is a red skin potato that is good for both mashed potatoes and fries It has high yields of large round tubers with shallow eyes and textured skin

Enabling TechnologylsquoRed Mariarsquo potato is a scab and golden nematode resistant variety with late season maturity

Inventors Walter De Jong amp Robert Plaisted

Licensee La Patate Lac-Saint-Jean

Plum lsquoCastletonrsquolsquoCastletonrsquo produces high quality dark purple fruit capable of achieving sufficient color for commercial fresh markets by mid-August The tree habit has fewer lateral and secondary lateral branches than other competing commercial cultivars which facilitates easy harvesting

Enabling TechnologyThe flesh of lsquoCastletonrsquo is yellow with high soluble solids and very good taste The medium vigor tree is very productive and has a spreading growth habit The fruits can be mechanically harvested

Patent PP09638 | Inventor Robert Andersen

Licensees Adams County Nursery Boyer Nurseries amp Orchards Inc CampO Nursery Cummins Nursery Flemingrsquos Nurseries amp Associates Pty Ltd Stark Brothers Nursery

Raspberry lsquoPreludersquolsquoPreludersquo is identified as the earliest ripening summer red raspberry beginning in mid-June under New York conditions Although lsquoPreludersquo is also fall bearing it produces the biggest portion of its crop in the spring lsquoPreludersquo berries are very winter hardy and vigorous

Enabling TechnologylsquoPreludersquo red raspberry gives growers the advantages of premium first fruit prices and season extension lsquoPreludersquo berries are round firm and attractive with a mild pleasant flavor

Patent PP11747 | Inventors Kevin Maloney Jack Reich amp John Sanford

Licensees Awalds Farm Berries Unlimited LLC Hartmann Plant Company Nourse Farms Inc Ontario Berry Growers Association Stargrow Nursery

Raspberry lsquoEncorersquoWith moderate winter hardiness and fruiting in late midseason lsquoEncorersquo berries are large with good raspberry flavor lsquoEncorersquo plants are vigorous sturdy upright and nearly spineless

Enabling TechnologyThe lsquoEncorersquo red raspberry cultivar matures a high percentage of its fruit from late July to early August which decreases the gap between the summer and fall harvest seasons In addition to its unique fruiting period lsquoEncorersquo offers consistent large fruit size throughout the entire harvest season lsquoEncorersquo is highly productive with conically shaped fruit well-balanced flavor and excellent firmness

Patent PP11746 | Inventors Kevin Maloney Jack Reich amp John Sanford

Licensees Awalds Farm Hartmann Plant Company Berries Unlimited LLC Nourse Farms Inc Ontario Berry Growers Association Stargrow Nursery

SabrExtrade for CornSabrExtrade for Corn has been shown to create more robust root systems induce resistance to plant stresses like dry weather or disease and increase water and nutrient efficiency SabrExtrade for Corn contains a unique patented strain of the beneficial fungus Trichoderma harzianum that works on most hybrids of corn and grows with the root system of the plant to help it grow larger stronger and more resistant to disease

SabrExtrade for WheatSabrExtrade for Wheat is a line of proven seed treatments for field crops It boosts tillering in wheat crops to create more plants and a more robust root system to absorb and carry more nutrients to the plant The result is a healthier sturdier plant that resists lodging and becomes easier to harvest

Enabling TechnologyThis technology involves a simple and effective process for encapsulating microbes for use in agriculture with particular emphasis on formulation of Trichoderma and Bradyrhizobium spp Multifunctional and crop specific blends of beneficial strains of Trichoderma microbes are used These microbes first colonize the crop root system That association with the plant induces gene expression and changes in plant physiology that enhances multiple biochemical pathways Crop stresses such as disease and dry weather can be alleviated and often systemically ndash so that root colonization by the seed treatment can affect the physiology of the whole plant even the leaf by creating bigger root systems and plant growth inducing resistance to plant stresses such as disease and drought increasing fertilizer and water use efficiency and increasing yields

Inventor Gary Harman

Licensee Advanced Biological Marketing (ABM)

Squash lsquoCelebrationrsquolsquoCelebrationrsquo is a gold striped acorn shaped hybrid winter squash

Squash lsquoHarlequinrsquolsquoHarlequinrsquo is a green striped acorn shaped hybrid winter squash with good eating quality

Enabling TechnologyEach of these varieties are bush type plants that have powdery mildew tolerance Both varieties produce fruit that average 112 lbs each These hybrid winter squashes were developed jointly by Cornell University and Rupp Seeds Inc

Inventors Margaret Jahn amp George Moriarty

Licensee Rupp Seeds Inc

Inventors Margaret Jahn amp George Moriarty

Licensee Rupp Seeds Inc

Squash lsquoBetternut 401rsquolsquoBetternut 401rsquo is a butternut variety that has good squash color and uniformity The plant produces three pound mature fruit and has a semi-bush habit that makes it good for smaller gardens

Enabling TechnologylsquoBetternut 401rsquo has powdery mildew tolerance and good crack resistance It matures in eighty days This hybrid winter squash was developed jointly by Cornell University and Rupp Seeds Inc

Strawberry lsquoSenecarsquolsquoSenecarsquo produces large bright red fruit The berries are glossy with good internal color flavor and yields

Enabling TechnologyAn impressively firm cultivar the lsquoSenecarsquo strawberry was released in 1991 after more than a decade of testing The lsquoSenecarsquo cultivar is exceptional because it combines high potential yield large fruit size extreme fruit firmness and consistently good fruit quality

Inventors Kevin Maloney Jack Reich amp John Sanford

Licensees Stargrow Nursery

Strawberry lsquoLrsquoAmourrsquolsquoLrsquoAmourrsquo is a variety with excellent fruit quality lsquoLrsquoAmourrsquo berries are bright red and firm with excellent flavor

Enabling TechnologylsquoLrsquoAmourrsquo is an exceptional June bearing strawberry It bears in early mid-season and yields glossy berries with remarkable flavor and attractiveness lsquoLrsquoAmourrsquosrsquo round conical fruit is firm but not hard with excellent eating quality With good winter hardiness lsquoLrsquoAmourrsquo is primarily adapted to the growing conditions of central New York and other regions of similar climate

Patent PP16480 | Inventors Kevin Maloney John Sanford amp Courtney Weber

Licensees Indiana Berry and Plant Co LLC Krohne Plant Farms Nourse Farms Inc Ontario Berry Growers Association Rusticas Del Guadalquivir SL Stargrow Nursery

Patent PP16571 | Inventors Kevin Maloney John Sanford amp Courtney Weber

Licensees Indiana Berry and Plant Co LLC Krohne Plant Farms Nourse Farms Inc Ontario Berry Growers Association Rusticas Del Guadalquivir SL Stargrow Nursery

Strawberry lsquoClancyrsquolsquoClancyrsquo plants are vigorous and fruit late similar season to lsquoCabotrsquo or lsquoErosrsquo lsquoClancyrsquo holds its berries high off the ground making them less susceptible to fungal diseases that usually attack late-season crops

Enabling TechnologyA June-bearing cultivar lsquoClancyrsquo is characterized by its vigorous late season fruit maturation and ability to produce a firm flavorful berry that is tolerant of hot weather

Squash lsquoTable StarrsquolsquoTable Starrsquo has 50 higher sugars than the competitive acorn squash on the market

Enabling TechnologylsquoTable Starrsquo is a new powdery mildew tolerant acorn squash that produces fruits averaging two pounds each It matures in seventy days This acorn squash was developed jointly by Cornell University and Rupp Seeds Inc

Inventors Margaret Jahn amp George Moriarty

Licensee Rupp Seeds Inc

TracFruitThe TracFruit products include TracApple TracPear TracGrape TracBerry TracCherry and TracStoneFruit The products are used for pest management related to the production of apples pears grapes berries cherries and stone fruits

TracTurfGrassThe TracTurfGrass products include TracLawn TracGolf TracGrounds) and TracSod The products offer users easy-to-use programs such as SiteLists ChemTables and SprayData to create detailed records and reports

Enabling TechnologyTrac software is a program designed for Integrated Pest Management It keeps records of pesticide applications generates reports for produce and helps analyze pest management strategies

Inventors Juliet Carroll Jennifer Grant Debra Marvin Judith Nedrow William Parken amp Kevin Walsh

Licensees More than 282 farms and orchards

Educational Ultrafast Fiber Laser KitThe Educational Ultrafast Fiber Laser Kit contains all the necessary components to build an all-fiber mode-locked laser oscillator Students can build their own mode-locked fiber laser using the carbon nanotube saturable absorber

CNT-1550-TK SeriesThe CNT-1550-TK compact femtosecond fiber laser is a mode-locked oscillator using fiber taper embedded in carbon nanotube saturable absorber Femtosecond pulses are delivered at the flip of a switch This is the first mode-locked laser powered by battery on the market

Enabling TechnologyThe carbon nanotube saturable absorber can improve the performance of sub-picosecond fiber lasers across a broad range of wavelengths enabling lasers with short pulses of high energies for applications in sensing medicine precision cutting guidance systems high-speed measurements and terahertz systems

Patnet 8384991 | Inventors Khanh Kieu amp Frank Wise

Licensee Kphotonics LLC

copyKphotonics LLC

DiamondWave FiberConnectFiberConnect allows users to dynamically manage and troubleshoot their fiber network from a Network Operations Center streamlining their fiber operations Functions include remote troubleshooting network installation verification fiber protection switching and hands-free network maintenance

Enabling TechnologyA low operating voltage micromirror array with individual addressable mirrors Two versions exist - one for adaptive optics and the second for spatial light modulation

Patents US 5198390 US 5199917 US 5287082 US 5316979 US 5375033 US 5397907 US 5399415 US 5426070 US 5506175 US 5536988 US 5627427 US 5628917 US 5640133 US 5719073 US 5726073 US 5770465 US 5786621 US 5844251 US 5846849 US 5847454 US 5914553 US 6000280 US 6027951 US 6051866

US 6073484 US 6093330 US 6239473 6342430 US 6456766 US 6541831 US 6794217 834218 (AT BE DK FI FR DE IT NL PT ES SECH GB) 2154357 (CA) 2224402 (CA) 693335513 (DE) 69942486

(DE) 683921 (FR GB) 1062684 (GB FR) 3896158 (JP) 4011617 (JP) Inventors Scott Adams Susanne Arney Fred Bertsch Liang-Yuh Chen

John Chong John Das Timothy Davis Xiaojun Huang Ali Jazairy Seung-Bok Lee Noel MacDonald James Mayer Scott Miller Bryan Reed

Muhammed Saif Kevin Shaw James Spallas James Sutherland Kimberly Turner Russell Webb Yang Xu Jun Yao amp Zuoying Zhang

Licensee Calient Networks Inc

copyCalient Networks Inc

JenLasreg D2fsJenLasreg D2fs is a femtosecond laser with optimized performance features for medical applications Designed for operation at pulse repetition rates it is capable of generating microstructures in organic tissue without causing thermal side effects

Enabling TechnologyThis technology is a fiber laser and new pulse shape capable of producing much higher energy ultrashort laser pulses It allows for pulses that are at least twice the pulse energy of prior femtosecond fiber lasers and in some cases pulse energies of one to two orders of magnitude larger can be produced

Patent US 7436862 | Inventors Joel Buckley William Clark F Oumlmer Ildayamp Frank Wise

Licensee JENOPTIK Laser GmbH

copyJENOPTIK Laser GmbH

LSM 7 MP and LSM 710 NLOMultiphoton microscopy (MPM) systems by Carl Zeiss use femto-(10-15) second lasers This pulsed ultrafast infrared laser excites fluorescent dyes at the focus only - the only place where photon density is high enough to produce fluorescence This focus results in only a small amount of their light being absorbed by biological tissues compared with visible excitation light The result is deep tissue penetration of the excitation light with low absorption and next to no scattering loss and only minimal phototoxic effects

Enabling TechnologyA laser scanning microscope produces molecular excitation in a sample by simultaneous absorption of two or more photons thereby providing three-dimensional resolution Fluorophores having single photon absorption in the ultraviolet or short visible wavelength range are excited by a beam of strongly focused femtosecond pulses of laser light in the red or infrared wavelength range The fluorophores absorb at about one half or smaller fraction of the laser wavelength to produce fluorescent images of living cells and other microscopic objects

Inventors Winfried Denk James Strickler Watt Webb amp Chris Xu

Licensee Carl Zeiss MicroImaging GmbH

copyCarl Zeiss MicroImaging GmbH

High Pressure Cryo-CoolerTM

HPC-201 cryocooling was developed as an alternative method for cryopreservation of macromolecular crystals The method requires the preservation of crystal hydration as the crystal is pressurized with dry helium gas With this method the specimen is kept hydrated via vapor diffusion in a shielding capillary while it is being pressure cryocooled After cryocooling the shielding capillary is removed to reduce background X-ray scattering It is shown that compared to previous crystalhydration methods the new hydration method produces superior crystal diffraction with little sign of crystal damage Using the HPC-201 a weakly diffracting protein crystal may be properly pressure cryocooled with little or no addition of external cryoprotectants and significantly reduced background scattering that can be observed from the resulting sample Beyond the applications for macromolecular crystallography it is shown that the HPC-201 has great potential for the preparation of non-crystalline hydrated biological samples for coherent diffraction imaging with future X-ray sources

Enabling TechnologyA method to cryo-cool protein crystals under high pressure has been developed This simple method involves pressurizing a protein crystal with noble gas which results in dramatic improvement in the collection of high resolution data and eliminates the need to use cryoprotectants The method can easily be extended to produce high-quality crystals from which high resolution amplitude and phase information can be simultaneously obtained by single anomalous diffraction (SAD)

Patent US 8030449 | Inventor Sol Gruner

Licensee Advanced Design Consulting Inc

PacBio RSThe PacBio RS sequencing technology resolves single molecules in real time allowing observation of structural and cell type variation not accessible with other technologies The PacBio RS system is ideally suited for a variety of applications from De Novo assembly and targeted sequencing to detecting base modifications

Enabling TechnologyThe PaBio RS uses Single Molecule Real-Time (SMRT) technology SMRT technology harnesses the natural process of DNA replication which is a highly efficient and accurate process The enzyme responsible for replicating DNA in nature is called the DNA polymerase The DNA polymerase attaches itself to a strand of DNA to be replicated examines the individual base at the point it is attached and then determines which of four building blocks or nucleotides is required to replicate that individual base After determining which nucleotide is required the polymerase incorporates that nucleotide into the growing strand that is being produced After incorporation the enzyme advances to the next base to be replicated and the process is repeated SMRT technology enables the observation of DNA synthesis as it occurs in real time

Patents US 5867266 US 6214246 US 6635163 US 7427343 US 7918979 US 6438279 US 6753200 US 7316769 US 7833398 US 7056661 US 7033764 US 7052847 US 7056676 US 7361466 US 7416844 US 7943307 US 7485424 US 7943305 US 6917726 US 7013054

US 7181122 US 7292742 1179085 (AT BE DK FR DE GR IE IT LU NL PT ES SE CH GB) 2373385 (CA) 1681356 (FR DE CH GB)

Inventors Harold Craighead Mathieu Foquet Jongyoon Han Jonas Korlach Michael Levene Stephen Turner Watt Webb amp Warren Wright

Licensee Pacific Biosciences of California Inc

copyPacific Biosciences of California Inc

MEMS AccelerometersAccelerometers to enable motion-based gaming user-interface functionality in mobile handsets personal navigation and TV remote controllers and hard-disk-drive drop protection in mobile products

Enabling TechnologyThe family of accelerometers was developed based on microelectromechanical (MEMS) product design process engineering and quality manufacturing Products are designed with submicron features and produced from a single crystal silicon substrate The unique design includes a movable portion supported by a multiple-beam structure and springs with controlled flexibility

copyKionix Inc

Patents US 5198390 US 5197499 US 5199917 US 5235187 US 5287082 US 5316979 US 5363021 US 5375033 US 5397904 US 5397907 US 5399415 US 5426070 US 5449903 US 5506175 US 5536988 US 5563343 US 5610335 US 5615143 US 5627427 US 5628917 US 5640133 US 5719073 US 5726073 US 5770465 US 5786621 US 5844251 US 5846849 US 5847454 US 5856722 US 5862003 US 5914553 US 6000280 US 6027951 US 6051866 US 6073484 US 6093330 US 6149190 US 6170332 US 6183097 US 6199874 US 6239473 US 6309077 US 6342430 US 6456766

US 6497141 US 6541831 US 6794217 834218 (AT BE DK FI FR DE IT NL PT ES SE CH GB) 2154357 (CA) 2224402 (CA) 693335513 (DE) 69942486 (DE) 702796 (DE GB IT FR) 683921 (FR GB) 907076 (FR GB CH DE) 1062684 (GB FR) 584233 (GB FR) 3657606 (JP) 3896158 (JP)

4011617 (JP) | Inventors Scott Adams Susanne Arney A Ayon Fred Bertsch Liang-Yuh Chen John Chong John Das Timothy Davis Dan Haronian Xiaojun Huang Ali Jazairy Nicholas Kolias Seung-Bok Lee Yu-Hwa Lo

Noel MacDonald James Mayer Scott Miller Gyorgy Porkolab Bryan Reed Muhammed Saif Kevin Shaw James Spallas

James Sutherland Kimberly Turner Russell Webb Yang Xu Jun Yaoamp Zuoying Zhang

Licensee Kionix Inc

Speedsterreg

The Speedsterreg Field Programmable Gate Arrays (FPGAs) are the worldrsquos fastest programmable logic devices Speedsterreg is fully reprogrammable yet still capable of operating at up to 15 GHz system performance which represents a three-fold increase in performance over existing FPGAs Speedsterreg is suitable for a wide range of telecommunications networking video digital signal processing high-performance computing imaging industrial and military applications

Enabling TechnologyHigh-performance highly pipelined asynchronous FPGAs employ a very ne-grain pipelined logic block and routing interconnect architecture These FPGAs which do not use a clock to sequence computations automatically ldquoself-pipelinerdquo their logic without the designer needing to be explicitly aware of all pipelining details The FPGAs include arrays of logic blocks or cells that include function units conditional units and other elements each of which is constructed using basic asynchronous pipeline stages such as a weak condition half buer and a precharge half buer

Patent US 7157934 Inventors Rajit Manohar amp John Teifel

Licensee Achronix Semiconductor Corporation

UltrOZtrade Elite SystemUltrOZtrade Elite is the first portable wearable long-duration ultrasonic therapy system for the treatment of common musculoskeletal conditions in horses UltrOZ has been used successfully to treat splints suspensory ligaments and tendons muscle strains stiff joints arthritis and bone fractures The portable system maximizes the advantage of using ultrasound by delivering the therapy every day without the need to tether the horse to a large bulky system The UltrOZtrade system comes in one easy-to-use package with battery pack and ultrasound applicator

Enabling TechnologyA portable high-power ultrasound system that can transfer more than 95 of the energy it generates to the ultrasound device Due to its high efficiency the unit can be run by a rechargeable battery pack and is thus adaptable to a handheld unit with the potential to replace unwieldy and more expensive medical systems

Inventors George Lewis amp William Olbricht

Licensee ZetrOZ LLC

copyZetrOZ LLC

VERSABALLreg

The VERSABALLreg is a robotic hand that is shaped and has the consistency of a stress ball Filled with a granular material it is flexible enough to envelop an object in one mode and strong enough to solidify around an object in a second mode This enables the VERSABALLreg to pick up a wide range of objects It isgentle enough to pick up a light bulb and strong enough to pick up objects weighing up to 20 pounds

Enabling TechnologyThis technology leverages the jamming phase transition of granular materials When granular material becomes dense the system has solid characteristics The process uses a combination of positive and negative pressure The positive pressure fluidizes the material creating better flow allowing the material to be flexible Negative pressure is then used to evacuate the air between granules increasing density and jamming the granules into a solid system Positive pressure is then used to release the granules and soften the system

Inventor Hod Lipson

Licensee Empire Robotics Inc

Antibody Against Cysteine DioxygenaseThis antibody is a research tool useful for the detection of cysteine dioxygenase protein in rodent and other mammalian tissues including human It will aid in the research on the protein and the understanding of its functions in metabolic pathways

Enabling TechnologyCysteine dioxygenase is an enzyme that catalyzes the oxidation of cysteine to cysteine sulfinic acid which is the first major step in cysteine catabolism in mammalian tissues It is a critical regulator of cellular cysteine concentrations

Inventor Martha Stipanuk

Licensee Abcam plc

Anti-SHMT1 Antibody The Anti-SHMT1 antibody has been validated for use in Western blotting and chromatin immunoprecipitation

Enabling TechnologySerine hydroxymethyltransferase (SHMT) is an enzyme that catalyzes the reversible conversion of serine and glycine SHMT is thought to be involved in DNA methylation mechanism and play important roles in cell proliferation and cell cycle This antibody will be useful in the study of cell growth and arrest

Inventor Patrick Stover

Licensee EMD Millipore Corporation

CEACH TestThe Colle Eye AnomalyChoroidal Hypoplasia (CEACH) test provides a powerful management tool for the breeder This genetic test can distinguish all three genetic states With this information the breeder can plan matings that avoid producing any affected dogs by always selecting one parent that is normal The other parent can be normal carrier or even affected and no affected dogs will result

Enabling TechnologyCEA is a canine hereditary ocular disorder affecting development of the choroid and sclera The disease segregates in several dog breeds including Rough and Smooth Collies Border Collies Australian Shepherds Lancashire Heelers and Shetland Sheepdogs This invention has identified the mutation associated with the CEA disease Specifically the critical region in which the CEA gene is located

Patents US 7462455 US 7723507 1652937 (AT BE CZ DK) 2005225033 (AU) | Inventors Gregory Acland Gustavo Aquirre Orly Goldstein

amp Anna Kukekova

Licensee OptiGen LLC

CSNB TestThe Congential Stationary Night Blindness (CSNB) test is a DNA-based test that provides a method to unequivocally identify CSNB in the Briard This will control the gene frequency in the breed so as to prevent producing puppies affected with the disease

Enabling TechnologyThe Briard dog is affected with a recessively inherited retinal disorder characterized by congenital night blindness with various degrees of visual impairment under photopic illumination called Congenital Stationary Night Blindness Vision in affected dogs ranges from normal day vision to profound day blindness In this invention RPE 65 the gene involved in CSNB has been isolated and the deletion mutation identified to permit genetic testing of Briards for this disease

Patents US 6201114 US 6428958 | Inventors Gregory Acland Gustavo Aguirre amp Kunal Ray

Licensee OptiGen LLC

Canigen CPV2bCanigen CPV2b is a vaccine comprised of live attenuated canine Parvovirus 2b Strain CPV39 and is approved for use in puppies from the age of five weeks to induce protection against CPV serotypes 2b 2a and 2

Enabling TechnologyCanine parvovirus (CPV-2) causes serious illness and mortality in dogs Puppies less than six months old are particularly susceptible This invention describes a new variant of the virus called CPV-2b which has become the dominant serotype of the virus found in dogs

Patents US 5814510 US 5885585 714171 (AU) 788372 (DE BE FR IT GB) 3762435 (JP) | Inventors Leland Carmichael Allen Gruenberg

amp Colin Parrish

Licensee Virbac Laboratories

prcd-PRA TestThe prcd-PRA test is done on a small sample of blood from the dog The test analyzes the specific DNA mutation causing the prcd-PRA The test detects the mutant abnormal gene copy and the normal gene copy The result of the test is a genotype and allows separation of dogs into three groups NormalClear Carrier and Affected

Enabling TechnologyProgressive Retinal Atrophy (PRA) is a heterogeneous class of retinal disorders that share a broadly similar clinical disease phenotype The dog may be classified into developmental and degenerative diseases This specific form of PRA is an autosomal recessively inherited late-onset retinal degenerations affecting several different breeds of dog This invention has identified the gene on chromosome 9 and the point mutation that causes prcd in dogs

Patents US 5804388 US 7312037 US 7671187 US 8206911 2005202704 (AU) 1609876 (AT BE CZ DK EE FI FR DE IE IT NL PL PT

ES SE CH GB) | Inventors Gregory Acland Gustavo Aguirre Orly Goldstein Susan Pearce-Kelling amp Barbara Zangerl

Licensee OptiGen LLC

IDEXX BVDV PI X2 Test The IDEXX BVD Antigen Test Kit is a USDA-licensed test for detecting persistently infected (PI) calves The kit offers superior sensitivity speed and simplicity compared to other test methods The IDEXX BVD Antigen Test Kit tests calves less than six months of age comes with reagents resistant to temperature fluctuations and offers simple ear-notch sampling with results in as little as five hours

Patents US 6174667 US 7449288 US 7459269 1018017 (AT BE DE DK FR GB GR IE IT NL PT SE CH) 738964 (AU) 2304546 (CA)

Inventor Edward Dubovi

Licensee IDEXX Laboratories Inc

Enabling TechnologyBovine viral diarrhea virus (BVDV) is one of the most costly bovine diseases worldwide with losses reported at $10-88 per head The major source of transmission is persistently infected (PI) calves which carry the virus throughout their lives continually infecting other animals A single PI calf sheds 1000 times more virus than an animal with a short-term BVDV infection Preventing economic losses from BVDV requires identifying and removing all PI calves

copyIDEXX Laboratories Inc

LP amp CSNB Test The genetic basis for Leopard Complex (LP) has been identified and this test can determine the specific mutation Large insertion within the gene known as TRPM1 is the mutation responsible for LP

Enabling TechnologyA popular source of symmetric white patterning called Leopard Complex also known as Appaloosa spotting is valued in the horse for its striking pattern However its highly variable nature and complex inheritance make it difficult for breeders to select homozygous animals for breeding stock in order to increase their production of desirable patterns Moreover Appaloosa horses homozygous for LP also have a condition called Congenital Stationary Night Blindness (CSNB) which requires careful management to avoid injury in dim light

Inventors Samantha Brooks amp Heather Holl

Licensees UC Davis Veterinary Medicine Animal Genetics Inc Maxxam Analytics International Corporation

RDOSD TestThe Inherited Retinal Dysplasia (RD)OculoSkeletal Dysplasia (OSD) test is done on a small sample of blood obtained by a veterinarian or on a cheek swab The test will identify dogs as being Normal Carrier or Affected with OSD

Enabling TechnologyRetinal dysplasia-retinal folds is common in many dog breeds and is benign and of unknown heritability As such breeding dogs with RD has been an acceptable practice However in two breeds the Labrador retriever and the Samoyed RD is of much greater concern as RD can be an indication that the dog is a carrier of OculoSkeletal dysplasia ndash a serious inherited syndrome in which dogs show various skeletal malformations and blindness at an early age The mutations responsible for OSD in the Labrador retriever and Samoyed have been identified and these mutations serve as the basis of a genetic test available to breeders who need to rule out all concern that OSD is playing a role in their dogrsquos diagnosis of RD

Patent US 8119343 | Inventors Gregory Acland Orly Goldstein Jennifer Johnson amp Anna Kukekova

Licensee OptiGen LLC

The Cornelltrade Collar The Cornelltrade Collar is a revolutionary throat support device for race horses to prevent soft palate displacement (upper airway obstruction) and maximize performance The device fits on like a bridle with the headstrap resting in front of the horsersquos ears and a lifting mechanism placed midline between the jaws This lifting mechanism serves to position the larynx in a more forward and upward location to prevent or minimize airway obstruction

Enabling TechnologyBased on years of research on dorsal displacement of the soft palate Unlike conventional treatments involving surgery the throat support device provides a non-invasive and convenient means of diagnosing and treating upper airway dysfunctions

Patent US 7036460 | Inventors Normand Ducharme Richard Hackett amp James Woodie

Licensee Vet-Aire Inc

copyVet-Aire Inc

Spaychekreg Spaychekreg is an ultra-sensitive and highly specific point-of-care diagnostic developed specifically to determine spay status in cats and dogs in a reliable and cost-effective manner

Enabling TechnologyThe traditional method for determining the reproductive status of a dog or cat is to look for an abdominal scar called a spay scar Spay scars are not always detectable in animals particularly when they have been spayed early in life Because animals are being spayed at ever younger ages a cost-effective reliable test was needed in order to avoid costly exploratory laparotomy This technology works by detecting the presence or absence of Anti-Mullerian Hormone (AMH) in cat or dog serum AMH is a hormone produced in the ovaries and released into circulation

Inventor Ned Place

Licensee Preventia LLC

copyPreventia LLC

WFFS Test Testing is easy and highly accurate and can be performed at any point in time in the life of the animal using EDTA blood or hair roots from the mane or tail All breeding animals should be tested to avoid major losses and heartache for owners

Enabling TechnologyWarmblood Fragile Foal Syndrome (WFFS) is an inherited systemic connective tissue disorder that is prevalent in Warmblood horses and related breeds It is typified by skin hyperextensibility and fragility and afflicted foals must be euthanized The mutation described in this invention represents the only one associated with WFFS of which we are currently aware and while it is not clear whether its absence means that the tested animal is normal the ability to test for this mutation will allow for proper breeding strategies of horses that are carriers so as to prevent progeny that are homozygous for this mutation

Inventor Nena Winand

Licensee LABOKLIN GmbH amp CoKG

Anti-Peroxiredoxins 1-4These antibodies are useful in research concerning redox signaling cancer and apoptosis

Enabling TechnologyPeroxiredoxins (Prxs) are antioxidant enzymes expressed by most free-living organisms often in multiple isoforms The development of antibodies specific to each of four human isoforms classified as 2-Cysteine Prxs peroxiredoxin 1 peroxiredoxin 2 peroxiredoxin 3 and peroxiredoxin 4 has enabled studies which can dissect the contributions of each specific isoform

Inventors Carl Nathan amp Chuanlu Shen

Licensees EMD Millipore Corporation Enzo Life Sciences International Inc Thermo Scientific Pierce Antibodies

Anti-pro-NGF AntibodyPro-NGF is the uncleaved precursor form of NGF Unlike other antibodies generated to the mature domain of NGF this antibody detects pro-NGF but not mature NGF

Anti-pro-BDNF AntibodyPro-BDNF is the uncleaved precursor form of BDNF The antibody detects pro-BDNF but not mature BDNF

Enabling TechnologyThe neurotrophins such as nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) are among the molecular determinants that regulate the generation of diverse neuronal populations and the maintenance of their functions within the nervous system This technology provides a powerful tool to regulate the cell fate through the p75 signaling pathway

Patents US 7507799 US 8034347 1575477 (DK GB)Inventors Barbara Hempstead Pouneh Kermani Ramee Lee amp Kenneth Teng

Licensee EMD Millipore Corporation

35-difluoro-4-hydroxybenzylidene imidazolinone35-difluoro-4-hydroxybenzylidene imidazolinone (DFHBI) is a small molecule fluorophore Upon binding to its aptamer this molecule exhibits the spectral properties of enhanced green fluorescent protein (EGFP)

Enabling TechnologyRNA has complex roles in cellular functions but an approach for fluorescently tagging RNA is lacking This technology has developed RNA sequences (RNA aptamer) which exhibit fluorescence upon binding a fluorophore Cellular RNA can be tagged with the RNA aptamer and fluoresce upon binding of the fluorophore This technology enables imaging of RNA and cellular metabolite both in vivo and in vitro

Inventors Samie Jaffrey amp Jeremy Paige

Licensee Lucerna Inc System Biosciences LLC

copyLucerna Inc

Championtrade pET SUMO Expression SystemThe Championtrade pET SUMO Protein Expression System offers an important tool for high-level soluble expression of proteins and peptides with native n-termini It uses a small ubiquitin-like modifier (SUMO) to allow expression purification and generation of native proteins in E coli

Enabling TechnologyA high-yield system for expressing and purifying proteins for use with proteins that are otherwise difficult or impossible to make in an active form due to their low solubility or poor folding

Patents US 6872551 US 7498165 US 7910364 1392717 (FR DE GB)Inventors Elena Goldberg amp Christopher Lima

Licensee Abbvie Inc Accelagen Inc Emerald Biostructures Genzyme Corporation Life Technologies Pfizer

Digycyl-Lysine Antibody clone GX41This is a monoclonal antibody which recognizes a diglycine modified lysine the trypsinized remnant of ubiquitination The recognition does not depend on neighboring backbone amino acid sequences It has been shown to specifically detect peptides derived from the ubiquitinated portion of proteins

Enabling TechnologyUbiquitination has been shown to be a critical step in various cellular processes including cell division signal transduction neurotransmission and development An antibody against the remnant of the trypsinized ubiquitinated proteins has been developed It specifically recognizes the diglycine modified lysines on their epsilon amines derived from ubiquitinated proteins It enables enrichment of peptides derived from ubiquitinated proteins and therefore significantly increases the efficiency of high-throughput identification of ubiquitination sites

Inventors Samie Jaffrey amp Guoqiang Xu

Licensees Abcam plc Enzo Life Sciences International Inc EMD Millipore Corporation Lucerna Inc

Antibody to mouse CD36CD36 is a cell surface class B scavenger receptor CD36 is preferentially found within lipid rafts which facilitates its association with receptors signaling and adapter molecules CD36 binds to collagen thrombospondin anionic phospholipids and oxidized LDL

Enabling TechnologyCD36 is a major platelet glycoprotein also found on white blood cells and some endothelial cells CD36 may play a role in cell adhesion as a receptor for thrombospondin (a multifunctional protein) Absence of CD36 protects against the formation of arterial plaques thus slowing the development of atherosclerosis CD36 deficiency also leads to heart disease in mice An IgA monoclonal antibody has been developed that reacts specifically with mouse CD36

Inventors Jongscheol Ahn Frederick deBeer Maria Febbraio amp Roy Silverstein

Licensees Becton Dickinson and Company Cayman Chemical Company Inc Hycult biotechnology bv KeraFAST Inc Novus Biologicals LLC

Immortalized Mouse Cardiac Endothelial Cell (MCEC) LineImmortalized Mouse Cardiac Endothelial Cell (MCEC) Line provides an excellent in vitro model for evaluation of the effects of specific genetic additions or deletions on endothelial physiology because these cells can be easily and stably transfected with different genes of interest It can also be used for drug development to study the responses of endothelial cell monalayers to different stresses and stimuli

Enabling TechnologyThe line was prepared by transfecting mouse cardiac endothelial cells with lentiviral vectors carrying SV40 T antigen and human telomerase genes

Inventors Silvia Barbieri Arunkumar Deora amp Babette Weksler

Licensee Cedarlane Laboratories Limited

JK1 Passage-Independent Feeder CellsJK1 is capable of promoting long term culture of primitive cells allowing for the identification of stromal derived factors that support long term proliferation of various types of stem cells This line can be passaged serially without losing its capacity to support stem cell self-renewal and survival making it a convenient alternative to other types of feeder layers for various stem and progenitor cells

Enabling TechnologyCurrent methods of culturing stem cells require the use of feeder cells including mouse embryo fibroblasts (MEFs) which can be inefficient and require constant preparation from fresh embryos or must be obtained commercially The JK1 cell line is derived from CD34+ mouse testicular stromal (MTS) cells and facilitates long term adult spermatogonial stem and progenitor cells (SPCs) in culture

Inventors Jiyeon Kim Shahin Rafii amp Marco Seandel

Licensee Cell Biolabs Inc

mVisiontrademVisiontrade is an integrated service platform designed to help industrial clients identify biochemical biomarkers from numerous chemical classes and various biological sample types including plasma serum urine cerebrospinal fluid cell extracts and tissues

mViewtrademViewtrade provides metabolomics-driven biochemical profiling for scientists in academic and government institutions An mViewtrade study detects and quantifies the biochemical changes that occur in cells under different conditions by comparing the small molecule profiles of samples under each condition The study involves quantifying hundreds of biochemicals in each sample eg amino acids carbohydrates lipids cofactors and nucleosides

Enabling TechnologyThis technology platform involves methods for drug discovery disease treatment and diagnosis using metabolomics The small molecule profiles of cells subjected to different conditions are compared to identify specific small molecules that are modulated by those conditions

Patents US 7005255 US 7329489 US 7682783 US 7682784 US 7635556 US 7550258US 7910301 US 7550260 US 7553616 US 7947453

Inventor Bruce Kristal

Licensee Metabolon Inc

NGFr (p75) AntibodyThis antibody recognizes the p75NTR in mouse Applications include immunohistochemistry immunoprecipitation immunoblotting flow cytometry and blocking the function of nerve growth factor receptor

Enabling TechnologyThe p75 neurotrophin receptor (p75NTR) also known as the low affinity nerve growth factor receptor binds proneurotrophins including pro-nerve growth factor pro-brain-derived neurotrophic factor pro-neurotrophin-3 and pro-neurotrophin-4 with varying specificities The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death

Inventors Moses Chao amp L Julie Huber

Licensee Advanced Targeting Systems

Lung VCAR Lung VCAR brings efficient CT pulmonary nodule assessment and diagnosis The innovative Digital Contrast Agent (DCA) feature automatically visualizes lung nodules to help doctors confirm the presence or absence of suspicious lesions from 2 to 12 mm in size and diagnose lunch cancer Lung VCAR allows automated follow-up for lesion matching by the registration of two or more datasets automatic lesion classification and a customizable reporting tool

Enabling TechnologyThis technology involves computer-aided methods for the three-dimensional segmentation analysis and diagnostic classification of small pulmonary nodules found in high-resolution computed tomography (CT) data

Patents US 7274810 US 8165385 US 8045770Inventors Claudia Henschke William Kostis Anthony Reeves

amp David Yankelevitz

Licensee GE Healthcare

SNPlexreg Genotyping SystemThe SNPlexreg Genotyping System enables the simultaneous genotyping of up to 48 SNPs (single nucleotide polymorphisms) against a single biological sample This system is ideal for fine mapping and candidate gene analysis population stratification and microarray replication studies

Enabling TechnologyThe technology uses Ligation Detection ReactionPCR technology for allelic discrimination and ligation product amplification Genotype information is then encoded into a universal set of dye-labeled mobility modified fragments for rapid detection by capillary electrophoresis

Patents US 5494810 US 6027889 US 6054564 US 6268148 US 6312892 US 6506594 US 6534293 US 6576453 US 6797470 US 6852487 US 6949370 US 7083917 US 7166434 US 7198894 US 7244831 US 7455965 US 7807431 US 7879579 US 7888009 US 7892746 US 7892747 US 7893233 US 7914981 US 7960159 US 8288521 US 8830711 730633 (AU) 735440 (AU) 736534 (AU) 776810 (AU) 776820 (AU) 780119 (AU) 781661 (AU) 2244891 (CA)

2255774 (CA) 22608818 (CA) 2348776 (CA) 2356697 (CA) 0956359 (CH GB) 697403181 (DE) 1343869 (DE IE NL IT) 1127135 (FR DE IE

GB) 4766750 (JP) 4294732 (JP) 4468488 (JP) 4598275 (JP) 4601830 (JP) 4883823 (JP) 4890411 (JP) 98183 (SG)

Inventors Francis Barany Reyna Favis Jianmin Huang amp Monib Zirvi

Licensee Applied Biosystems by Life Technologies

copyApplied Biosystems by Life Technologies

Renal Transplant MonitoringKidney transplantation is the treatment of choice for end-stage renal disease This test measures RNA expression levels of FoxP3 granzyme B and perforin genes in blood from transplant recipients as an indirect indicator of immune response so as to detect or monitor renal transplant rejection

Enabling TechnologyAcute rejection is an important risk factor for renal allograft failure and it is typically diagnosed by a histological analysis of the allograft tissue obtained by core needle biopsy This invasive procedure carries risks including graft injury or loss Scientists determined that increased expression of certain immune activation genes was detected in the blood upon allograft rejection which could serve as a non-invasive alternative method to detect this rejection This technology is jointly owned by Cornell University and Beth Israel Deaconess Medical Center

Patent US 6187534 | Inventor Manikkam Suthanthiran

Licensee Quest Diagnostics Incorporated

NIAGENTM

NIAGENtrade is the first and only commercially available brand of Nicotinamide Riboside (NR) that maintains and enhances mitochondrial health by boosting NAD+ levels This can lead to improved endurance due to enhanced mitochondrial function and has shown to lower high-fat-diet-induced weight gain by enhancing energy metabolism and promotes healthy cellular metabolism

Enabling TechnologyNicotinamide riboside (NR) is an effective precursor to NAD+ which plays a key role in cellular metabolism and energy production This technology uses highly effective synthetic methods to generate novel analogs of NR These novel compounds and high efficiency synthetic methods provide opportunities to manipulate NAD levels and thereby to modulate the activity of sirtuins and other ADP-ribosyl transferases The compounds can be used to destroy or weaken the defenses of cancer cells to promote survival of neurons myocytes or stem cells to hold stem cells in an undifferentiated state and promote their survival or to reduce side effects caused by other therapeutics

Patent US 8106184 | Inventor Anthony Sauve

Licensee

LabcliQLabcliQ is an online program for workflow and inspections for environmental health and safety departments Users can identify compliance issues provide supporting resources implement corrective action programs and generate key information from real time inspection data LabcliQ is hosted off-site and can be accessed over any web browser with no need for customized hardware or software

Enabling TechnologyThis online inspection tool was invented by staff of the Environmental Health amp Safety Department Cornell Information Technologies Department Facilities Services Division and Human Resources Division It provides data and metrics through a corrective action tracking system to environmental health and safety staff as well as empowering stakeholders with tools to assist them in managing environmental health and safety issues within areas of their responsibility

Inventors Curtis Baker Jason Becraft Laurie Cecere Brenda Coolbaugh Mark Fowler Robin Goodloe Jerry Gordon amp Greg Smith

Licensee SafetyStratus Inc

copySafetyStratus Inc

Who We AreThe Center for Technology Licensing (CTL) is Cornell Universityrsquos technology transfer office We manage technologies and plant varieties for Cornell University at the main campus in Ithaca the Weill Cornell Medical College campus in New York City and the New York State Agricultural Experiment Station in Geneva Our goal is to support Cornellrsquos land-grant mission and to promote public good by connecting Cornell technology to industry and business development efforts

What We Dobull Promote beneficial interactions between Cornell researchers and industrybull Partner with industry to develop Cornell technologies and plant varieties into products and services for public goodbull Leverage Cornell innovations to promote the formation of new businesses based on Cornell technology to fuel regional economic development

How We Do Itbull By marketing patenting and licensing innovations from Cornell researchbull By hosting networking events to connect Cornell researchers industry and entrepreneursbull By increasing awareness on campus of the value of commercializing and protecting Cornell innovations

Patent pending

Plant Breedersrsquo Rights pending

Center fortechnologyl i c e n s i n gat cornell universityCTL

wwwctlcornelledu ctl-connectcornelledu

395 Pine Tree Road Suite 310 Ithaca NY 14850 p 6072544698 f 6072545454418 East 71st Street Suite 61 New York NY 10021 p 2127466186 f 2127466662

copy2015 Center for Technology Licensing at Cornell University

Center fortechnologyl i c e n s i n gat cornell universityCTL

wwwctlcornelledu ctl-connectcornelledu

395 Pine Tree Road Suite 310 Ithaca NY 14850 p 6072544698 f 6072545454418 East 71st Street Suite 61 New York NY 10021 p 2127466186 f 2127466662

copy2015 Center for Technology Licensing at Cornell University