product list...(d,l)-amide (l)-t-leucineracemization of (d)-amide o ho r 2 r 1 base1 + base 2 enzyme...
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(D,L)-Amide (L)-t-LeucineRacemization of(D)-Amide
OHO
R2 R1
Base 1Base 2+ Enzyme
Enzyme
Crystallization
NH2
NH2
O OH
NH2
O
Intermediates of HIV Protea
Proprietary Gene Expression Sys
Enzyme Application
2’-Deoxy, 2’, 3’-dideoxy, 2’-Ribo, 2’-Fluoro, A
Chiral Aziridines
Z - O
X
NNO
OP
P
Active Pharmaceutical Ingredients (APIs)
Classification Generic Name Cas No. Chemical Structure Offering Stage Specification DMF Status Remark
Anti-viral
D-Cycloserine 68-41-7 Commercial USP Available Anti-Tuberculosis
Terizidone 25683-71-0 Commercial In House Available Anti-Tuberculosis
Atazanavirsulfate 229975-97-7 Pilot USP - Anti-HIV/AIDS
Entecavir 68-41-7
Commercial In House Available Hepatitis B
Anti-Fungal Voriconazole 137234-62-9 Commercial EP Available Antifungal
Diagnosis
Gadobutrol 138071-82-6 Commercial EP Available MRI ContrastAgent
Gadoteridol 120066-65-8 Under-development - -MRI ContrastAgent
Gadoxetatedisodium 135326-22-6
Under-development - -
MRI Contrast Agent
Anti-Coagulant Clopidogrel bisulfate [Form I] 120202-66-6 Commercial USP Available Anti-thrombotic
CNS Lacosamide 175481-36-4 PV Completed In House Available Epilepsy
Product ListProduct List
* Some of products listed above may be subject to intellectual property (IP) and shall be offered only to eligible relevant IP holder or licensee. In case relevant IP coverage to the user is not available, those products shall be offered for non-commercial research purpose only under buyer's full reponsibility and shall not be used for any other purpose.
O
RO
DMTrO Basep Basep Basep
O
ROH
DMTrO
O
ROH
HO
PN(iPr)2O
NC
Basep Basep Basep
O
HO
DMTrO
O
HR
DMTrO
O
HOH
HO
PN(iPr)2O
NC
2’-Fluoro Phosphoramidites 5’-O-DMT-3’-CEP-2’-F-ribonucleosides (A,C,G,U)
RNA Phosphoramidites (2’-O-TBDMSi) 5’-O-DMT-3’-CEP-2’-O-TBDMSi-ribonucleosides (A,C,G,U)
2’-OMethyl Phosphoramidites 5’-O-DMT-3’-CEP-2’-O-Me-ribonucleosides (A,C,G,U,T)
Precursors of Phosphoramidites (unprotected and protected nucleosides)
2’-O-Methyl ribonucleosides (A,C,G,U) 2-Fluoronucleosides (A,G,C,U) Base Protected ribonucleosides (A,C,G,U) 5’-O-DMT protected ribonucleosides (A,C,G,U)
MOE (2’-O-methoxyethyl)-amidites (A,C,G,U) CEM (2’-O-cyanoethylmethoxy)-amidites(A,C,G,U) LNA (2’,4’-locked)-amidites (A,C,G,T) cEt (2’,4’-constrained ethyl)-amidites (A,C,G,U,T) 3’-Amino-2’,3’-dideoxy-5’-amidites (A,C,G,T) Morpholino-amidates
• Custom manufactured for IP eligible end-users only; subject to IP clarification before supplies.
• Available per inquiry of various types of specialty modified nucleosides and phosphoramidites
Offered Supply Scale : • High throughput-scale to GMP kilogram-scale• Non-GMP grade : nmole to 10-gram scale• GMP-grade : 50-gram ~ 500kg scale
(L)-nucleosides and (L)-/(D)-sugars 2’-Deoxy-D-ribose 1-Chloro-2-deoxy-3,5-bis (O-p-toluoyl)-L-ribofuranose 1-O-Acetyl-2,3,5-O-tribenzoyl-D-ribofuranose
Halogenated and Other nucleosides 5-Fluoro-deoxyuridine (Floxuridine) 5-Iodo-deoxyuridine (Idoxuridine) 5-Methyl-deoxycytidine 5-Methyl-uridine 2’-Deoxyuridine 2’-Deoxyinosine Arabinofuranosyl-2,6-Diaminopurine (Ara-DAP)
Offered Oligo types : • Antisense, siRNA, Aptamer, CpG, Decoy, Diagnostic probes• Various modification and conjugation PEG, Cholesterol, Amino-,Thiol-, Phosphates, etc.
Base : Adenine, Guanine, Cytosine, Uracil P : Acetyl, i-Butyl, Benzoyl, etc R : OH, OTBDMS, F, OMe
DNA Phosphoramidites 5’-O-DMT-3’-CEP-2’-deoxynucleosides (A,C,meC,G,T)
*CEP : ß-Cyanoethylphosphoramidite
Precursors of Phosphoramidites (unprotected and protected nucleosides)
2’-Deoxynucleosides (A,C,meC,G,T,U) Base Protected-2’-deoxynucleosides (A,C,G,T) 5’-O-DMT Protected-2’-deoxynucleosides (A,C,G,T) 5’-O-DMT 3’-O-Succinyl-2’-deoxynucleosides (A,C,G,T)
Base : Adenine, Guanine, Thymine, Cytosine P : Acetyl, i-Butyl, Benzoyl, dmf etcR : OH, O-Succinyl
Amidites & Nucleoside Monomers
For RNAs & 2’-modifies RNAs
Specialty Amidites
For DNAs
Miscellaneous Nucleosides
Oligonucleotides
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Pharmaceutical Intermediates
Classification Generic Name Cas No. Chemical Structure Offering Stage Remark
Chiral
(R)-3-(benzyl carbamo)yl-4-(2,4,5-trifluorophenyl)butanoic acid
1246960-25-7[FAA(P1)] Commercial
Intermediates of DPP-IV inhibitors
(2R,3S)-N-(tert-butoxycarbonyl)-3-amino-1,2-epoxy-4-phenylbutane
98760-08-8[RBEP] Commercial
Intermediate of Protease inhibitors (Atazanavir, etc)
Nucleoside
Phosphoramidites(A,C,G,U,T) - Commercial
Starting material of Oligonucleosides
2-Fluoronucleosides(A,G,C) - Commercial
2’-Deoxynucleosides(A,C,G,T,U) - Commercial
2’-OMe-nucleoside - Commercial
Carbohydrate
2’-Deoxy-D-ribose 533-67-9
[2DR] CommercialStarting material of Nucleoside APIs
N-Acetylmannosamine 7772-94-4[NAMH] CommercialStarting material of N-Acetylneuraminic acid
1-Chloro-2-deoxy-3,5-bis(O-p-methylbenzoyl)-L-ribofuranose
3601-89-6[LYII7] Commercial
Intermediate of Telbivudine
Active Pharmaceutical Ingredients (APIs)
Classification Generic Name Cas No. Chemical Structure Offering Stage Specification DMF Status Remark
MetabolicDisease
Sitagliptinphosphate 654671-77-9 PV Completed EP -
Diabetes mellitus
Evogliptin 1246960-27-9 Commercial In House Available Diabetes mellitus
Atorvastatin calciumtrihydrate
344423-98-9 Commercial EP Available Anti-Hyperlipidemia
Rosuvastatincalcium 147098-20-2 Commercial EP -
Anti-Hyperlipidemia
Anti-Hypertensive Valsartan 137862-53-4 Commercial USP - Hypertension
RespiratoryDisease
Formoterolfumarate dihydrate
183814-30-4 Commercial KP - COPD
Others Udenafil 268203-93-6 Commercial In House Available Erectile dysfunction
Product ListProduct List
* Some of products listed above may be subject to intellectual property (IP) and shall be offered only to eligible relevant IP holder or licensee. In case relevant IP coverage to the user is not available, those products shall be offered for non-commercial research purpose only under buyer's full reponsibility and shall not be used for any other purpose.
* Some of products listed above may be subject to intellectual property (IP) and shall be offered only to eligible relevant IP holder or licensee. In case relevant IP coverage to the user is not available, those products shall be offered for non-commercial research purpose only under buyer's full reponsibility and shall not be used for any other purpose.