product information leaflet glycare 2fl · phone: +86 21 6141 8188 fax: +86 21 6141 8088 email:...
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Early life nutrition innovation from DSMProviding the best infant nutrition is vital for all families. That’s why DSM is proud to offer GlyCare™ HMOs. These compounds are developed with science-backed quality and safety at their core. As the only fully integrated and broadest HMO provider, DSM can reliably provide ease-of-scale no matter the size of your business. Partner with us to get your products one step closer to what nature intended.
PRODUCT INFORMATION LEAFLET
The most abundant fucosylated HMO in human milk
GlyCare™
2FL
The best nutrition for infants is a mother’s breastmilk, which includes essential nutrients important for an infant’s growth and development. Recent research shows that one of the largest differentiating features of breastmilk compared to cow’s milk-based infant formula is the concentration and variety of milk oligosaccharides.1 Until recently, HMOs have not been part of infant formula.
You can see the macronutrients composition in human milk in the chart to the right:
Breastmilk – the gold standard
Human Milk Oligosaccharides (HMOs): delivering the benefits nature intended
Uniquely human
• HMOs are complex carbohydrates found in human breastmilk
• No other mammal has near the concentration and complexity of structures in their milk1
Potential functional benefits of GlyCare™ 2FL, as demonstrated in pre-clinical and clinical trials
• A combination of GlyCare™ 2FL and GlyCare™ LNnT may reduce incidence of colic in infants born via cesarean section11
• Emerging science suggests a potential role in normal gut motility12
COMFORT
DEVELOPMENT
• Emerging evidence suggests a potential role in cognitive development13,14,15
• Helps balance gut microbiota by stimulating beneficial bacteria such as bifidobacteria16
COMFORT
DEVELOPMENT SUP
PORTAbundance and diversity in human milk
• 3rd largest component of human milk
• >200 different HMOs identified in human milk, a diversity not seen in other animal milks1
• Variation in concentration and diversity occurs over lactation period, by maternal genetics, geographic region, and ethnicity2
• May support gut barrier function20,21
• May help support normal immune function5,7
STRENGTHEN
• Emerging scientific evidence suggests a potential positive role in inflammation6,17
• In a clinical study supplementing infant formula with Glycare™ 2’FL and Glycare™ LNnT, there were significantly fewer parental reports of bronchitis, lower respiratory tract infections, and antipyretic and antibiotic use11
• May help support a normal immune system18,19
DEVELOPMENT SUP
PORT
* Around 2g/L. † Presence of 2FL is dependent upon maternal genotype and, thus, may be population specific.1,2
Of all HMOs, 2’FL is the most abundant in human milk*†
• Found in the milk of most of lactating women2
• May play a role in digestive and immune health7,9,10
Complex structures with potential functional benefits
• Help establish a balanced early-life microbiota3,4
• Contribute to immune system support8,9,10
Proteins
Lactose
Lipids
Milk oligosaccharides
GlyCare™ 2FL product information
• 5+ years of shelf life from production date
• Purity levels range from 96-98% depending on the variant
• Suitable for lacto ovo vegetarians
• Available in different variants such as KfP, hypoallergenic, crystallized and amorphous powder
• White, homogenous powder with a neutral to slightly sweet taste
• Contains trace levels of lactose*
* according to EC regulation 1169/2011 annex II
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* We are continuously expanding our global approval footprint across application areas. For more details, please ask for our Regulatory Overview.
The full GlyCare™ HMO portfolio• GlyCare™ 2FL
• GlyCare™ LNnT
• GlyCare™ 2FL/DFL
• GlyCare™ 6SL
• GlyCare™ 3SL
• GlyCare™ LNT
• GlyCare™ 3FL
• GlyCare™ LNFP-I
References1. Ruhaak and Lebrilla Adv Nutr. 2012; 3(3): 406S–414S
2. Vandenplas Y, et al. Nutrients. 2018;10(9)
3. Berger et al. Mbio. 2020; volume 11 Issue 2 e03196-19
4. Bezirtzoglou et al. Anaerobe 2011; 17,478–482
5. Goehring KC, et al. J Nutr. 2016;146(12):2559-2566
6. Sodhi, C. P. et al. Pediatric Research. 2020; 1–11
7. Mezoff, E. A. et al. American Journal of Physiology 2016; 310(6), G427–G438
8. Newburg et al. Adv Exp Med Biol. 2004; 554: 457-461
9. Reverri, E.J. et al. Nutrients. 2018; 10: 1346
10. Marriage, B.J. et al. JPGN 2015; 61: 649–658
11. Puccio G, et al. J Pediatr Gastroenterol Nutr. 2017;64(4):624-631
12. Bienenstock, J. et al. PLoS ONE 8(10):e76236
13. Berger PK et al. PLOS ONE. 2020; 15(2): e228323
14. Oliveros E, et al. J Nutr Biochem. 2016; 31:20-27
15. Vázquez E, et al. J Nutr Biochem. 2015;26(5):455-465
16. Yu, Z.T., C. Chen, and D.S. Newburg Glycobiology. 2013; 23(11):1281-92
17. Grabinger, T. et al. Frontiers in Microbiology. 2019; 10, 1–14
18. Castillo-Courtade L, et al. Allergy. 2015;70(9):1091-1102
19. Sprenger N, et al. Euro J Nutr. 2017;56(3):1293-1301
20. Kong, C. et al. Molecular Nutrition and Food Research 2019; 63(17)
21. Holscher, H. D. et al. The Journal of Nutrition. 2014; 144(5), 586–591
DISCLAIMER Although DSM has used diligent care to ensure that the information provided herein is accurate and up to date, DSM makes no representation or warranty of the accuracy, reliability, or completeness of the information. This brochure only contains scientific and technical information for business to business use. Country or region-specific information should also be considered when labeling or advertising to final consumers. This publication does not constitute or provide scientific or medical advice, diagnosis, or treatment and is distributed without warranty of any kind, either expressly or implied. In no event shall DSM be liable for any damages arising from the reader’s reliance upon, or use of, these materials. The reader shall be solely responsible for any interpretation or use of the material contained herein. The content of this document is subject to change without further notice. Please contact your local DSM representative for more details. All trademarks listed in this brochure are either registered trademarks, trademarks or licensed trademarks of DSM group of companies in the Netherlands and/or other countries, unless explicitly stated otherwise.
© DSM Nutritional Products 2020
For more information, please visit our website www.dsm.com/human-nutrition
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DSM GlyCare™ HMOs are produced to the highest quality of certifications, approvals, and procedures
ISO 9001:2015 HalalKosherSMETAFSSC 22000
The full GlyCare™ HMO portfolio• GlyCare™ 2FL
• GlyCare™ LNnT
• GlyCare™ 2FL/DFL
• GlyCare™ 6SL
• GlyCare™ 3SL
• GlyCare™ LNT
• GlyCare™ 3FL
• GlyCare™ LNFP-I